Prof. T.B.H. Geijtenbeek PhD

foto

Prof. T.B.H. Geijtenbeek PhD

Position
Full Professor
Main activities
Research, Other
Specialisation
Immunology
Focus of research

We investigate  how pathogens and in particular viruses (HIV-1, SARS-CoV-2, Zika and Dengue virus) infect humans. We thereby study mucosal dendritic cells that function as sentinels that sense invading pathogens and induce appropriate immune responses. However, specific viruses hijack the dendritic cells to establish dissemination throughout the body. Thus, dendritic cells are important in determining the susceptibility of humans to viruses such as HIV-1 and SARS-CoV-2. We use primary human dendritic cells isolated from skin and mucosal tissues and we have also developed different ex vivo human tissue infection models to investigate virus susceptibility in a physiological relevant model. We aim to identify the molecular mechanisms triggered by the pathogens to infiltrate the body via dendritic cells and this will provide novel targets to counteract infections or induce specific immune responses.

Key publications
  • Gringhuis Sonja I., Hertoghs Nina, Kaptein Tanja M., Zijlstra-Willems Esther M., Sarrami-Fooroshani Ramin, Sprokholt Joris K., van Teijlingen Nienke H., Kootstra Neeltje A., Booiman Thijs, van Dort Karel A., Ribeiro Carla M. S., Drewniak Agata, Geijtenbeek Teunis B. H. HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3 Nature immunology 2017;18 (2):225-235 [PubMed]
  • Ribeiro Carla M. S., Sarrami-Forooshani Ramin, Setiawan Laurentia C., Zijlstra-Willems Esther M., van Hamme John L., Tigchelaar Wikky, van der Wel Nicole N., Kootstra Neeltje A., Gringhuis Sonja I., Geijtenbeek Teunis B. H. Receptor usage dictates HIV-1 restriction by human TRIM5α in dendritic cell subsets Nature 2016;540 (7633):448-452 [PubMed]
  • Geijtenbeek Teunis B. H., Gringhuis Sonja I. C-type lectin receptors in the control of T helper cell differentiation Nature reviews. Immunology 2016;16 (7):433-448 [PubMed]
  • Sprokholt Joris K., Kaptein Tanja M., van Hamme John L., Overmars Ronald J., Gringhuis Sonja I., Geijtenbeek Teunis B. H. RIG-I-like receptor activation by dengue virus drives follicular T helper cell formation and antibody production PLoS pathogens 2017;13 (11):e1006738 [PubMed]
  • Nijmeijer Bernadien M., Eder Julia, Langedijk Catharina J. M., Kaptein Tanja M., Meeussen Sofie, Zimmermann Pascale, Ribeiro Carla M. S., Geijtenbeek Teunis B. H. Syndecan 4 Upregulation on Activated Langerhans Cells Counteracts Langerin Restriction to Facilitate Hepatitis C Virus Transmission Frontiers in immunology 2020;11 [PubMed]
All Publications
Curriculum Vitae

Name               Teunis B.H. Geijtenbeek (male)

Date of birth     April 25, 1969 Scherpernzeel, the Netherlands 

Nationality       Dutch

Title                 Professor in Molecular and Cellular Immunology

Position           Head of department of Experimental Immunology, AMC

URL web site  www.amc.nl/experimentalimmunology

                        www.amc.nl/tbgeijtenbeek

 

Education

1996                PhD degree, department of Biochemistry, Utrecht University, Utrecht, the Netherlands

1991                Master degree in Chemistry, Utrecht University, Utrecht, the Netherlands

 

Professional activities

2016- present   AMC Director of the Amsterdam Infection & Immunity Institute (AMC/VUmc)

2012- present   Head of the department of Experimental Immunology, AMC, Amsterdam, the Netherlands 

2009- present   Professor in Cellular and Molecular Immunology, UvA/AMC, UvA Amsterdam, The Netherlands

2009-2011       Groupleader in the Center of Experimental Molecular Medicine, AMC, Amsterdam Netherlands

2006-2009       Associate Professor, Molecular Cell Biology and Immunology, VUmc, Amsterdam, the Netherlands

2001-2006       Assistant Professor, Molecular Cell Biology and Immunology, VUmc, the Netherlands

1999-2000       Visiting scientist, Littman Lab, Skirball Institute, NYU, New York, USA

1996-2001       Postdoctoral fellow, Tumor Immunology, UMC St Radboud, Nijmegen, the Netherlands

 

(Inter)national scientific management/editorial functions

2020-present    Chairman COVID-19 Experimental Research Unit (Amsterdam UMC)

2017-present    Board member of the Amsterdam Research Board  (Amsterdam UMC)

2017-present    Chairman of the AMC VICI/ERC Grant Support group

2013-present    Board member scientific committee the Dutch HIV-1 Monitoring foundation (SHM)

2013-2019       Board member of the AMC PhD Graduate School

2012-present    Board member scientific committee AIDS Foundation (AIDS Fonds), Amsterdam, the Netherlands

2012/2013       Organizer of the bi-annual Langerhans cell 2013 Meeting in Amsterdam, the Netherlands

2011-2015       Chair of the research institute Center for Immunology Amsterdam, the Netherlands

2011-present   Member of the FANTOM consortium, which aims to map the majority of human promoters and generate transcriptional regulatory network models of each cellular                               state.

2010-present    Editorial board of Frontiers in Immunology/AIDS

2009-present    Academic editor PLoS ONE

2008-present    Member of program committee of the Dutch Society for Immunology (NVVI)

2006-present    I have developed and am teaching different courses in Immunology, Cell Biology and Immunology for Bachelor and Master students (faculty of Medicine, faculty of                            Earth and Life Sciences) at the VUmc and AMC, Amsterdam, the Netherlands (third place of best teacher 2009, chosen by the Medical students at the VUmc)

2005-2009       Coordinator Medical Biochemistry for Bachelor students at the faculty of Earth and Life Sciences, VU University, Amsterdam

2005-2007       Coordinator development of the Bachelor curriculum for Medical students at the VUmc

 

I have participated in review committees for laboratory evaluation for INSERM (as chair: France) and for Linkoping University (Sweden).

I am regularly reviewing for international journals such as Nature, Nature Science, Medicine, Nature Immunology, Immunity, Science Immunology, Cell Host & Microbe, Blood, PLoS Medicine, PLoS Biology, PLoS Pathogen, Journal of Immunology and Journal of Virology. I have reviewed over 70 research proposals, both national (NWO VENI, VIDI, VICI, and KNAW SPIN) and internationally (Wellcome Trust, ERC Advanced, and ETH Research Proposal).

Awards and honours

2015                Advanced ERC award

2010                VICI award for innovative research by excellent senior researchers, the Netherlands Organization for Scientific Research (NWO)

2003                VIDI award for innovative research by excellent young postdoctoral researchers, the Netherlands Organization for Scientific Research (NWO)

2004                BD Biosciences Award of the European Macrophage and Dendritic Cell Society in recognition of outstanding contributions in immunology and virology

2000                AIDS Research Amsterdam (ARA)-award for excellent scientific research in the area of retroviruses; identification of the first innate HIV-1 sensor DC-SIGN

 

International collaborations

  • The Scripps Research Institute, La Jolla, USA (Dr. P. Gallay); HIV-1 and HCV pathogenesis (joined publications: de Jong et al. J Clin Invest 2008; Bobardt et al. PNAS 2007; de Witte et al. PNAS 2008).
  • Harvard Medical School, Boston, USA (Dr. M. Gack); MV immunosuppression (joined publications: Mesman et al. Cell Host Microbe 2014; Davis et al. Cell Host Microbe 2014).
  • Boston University School of Medicine, Boston, USA (Dr. P. Duprex); MV dissemination (joined publications: de Swart et al. PLoS Pathog 2007; Lemon et al. PLoS Pathog 2011; Mesman et al. PLoS ONE 2012; Mesman et al. Cell Host Microbe 2014; Davis et al. Cell Host Microbe 2014).
  • University of Cardiff, Wales, UK (Prof. dr. V. Piguet); DC function and HIV-1 infection (joined publications: Engering et al. J Immunol 2002; Arrighi et al. J Exp Med. 2004; de Witte et al. Nat Med 2007).
  • University of Frankfurt, Frankfurt, Germany (Prof. dr. O. Keppler); HIV-1 infection and transmission.
  • Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland (dr. M. Carrington); HIV-1 transmission cohorts.

(Co)promotorship and mentorship

I have personally supervised 16 PhD graduations since 2001, of which 2 with honours. I have been the promotor of 10 PhD graduations. Currently, I am the promotor of 12 PhD students. I have been a member of the PhD thesis defense committee on more than 40 occasions. I have supervised 10 postdoctoral researchers and currently supervise 2 postdoctoral researchers. My group has supervised over 15 MSc students during their internship over the last five years.

Teaching and dissemination activities

I have been invited to more than 60 international established conferences since 1996. Furthermore, I have been (invited) lecturer and/or course coordinator of more than 45 courses (since 2001) in Immunology, Infectious diseases, Clinical Immunology, Medical Biochemistry at Bsc, Msc and PhD level at various (inter)national institutes and scientific events. Currently, I am involved in PhD student courses in four different University Medical Centers (AMC, VUmc, UMC Utrecht and Leiden UMC). I have participated in more than 10 public information days where I have explained my research on HIV-1 transmission to the general public (AMC, VUmc and UMC St Radboud Nijmegen). I have given radio interviews as well as newspaper interviews on my discoveries concerning sexual transmission of HIV-1 and effect of co-infections on HIV-1 susceptibility. I participate yearly in masterclasses on HIV-1 transmission to medical doctors.

Publications   

Web of Science: Search results for Author {Geijtenbeek TB*; Geijtenbeek TBH}

Total number of publications: 178; Hirsch Factor 59 

Total citations (without self-citations): 13044; Average citations/pub: 87.75; over 1000 citations/per year (since 2009).

 

Top 5 selected publications as senior author

 

1    Ribeiro CM, Sarrami-Forooshani R, Setiawan LC, Zijlstra-Willems EM, van Hamme JL, Tigchelaar W, van der Wel NN, Kootstra NA, Gringhuis SI, Geijtenbeek TB. (2016). Receptor usage dictates HIV-1 restriction by human TRIM5alpha in dendritic cell subsets. Nature 540: 448-52 . (IF 38.1)

2    Gringhuis SI, Hertoghs N, Kaptein TM, Zijlstra-Willems EM, Sarrami-Fooroshani R, Sprokholt JK, van Teijlingen NH, Kootstra NA, Booiman T, van Dort KA, Ribeiro CM, Drewniak A, Geijtenbeek TB. (2017). HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3. Nat Immunol 18: 225-35. (IF 19.4)

3.   Geijtenbeek TB, Gringhuis SI. 2016. C-type lectin receptors in the control of T helper cell differentiation. Nat Rev Immunol 16: 433-48 . (IF 39.4)

4.   Mesman,A.W., Zijlstra-Willems,E.M., Kaptein,T.M., de Swart,R.L., Davis,M.E., Ludlow,M., Duprex,W.P., Gack,M.U., Gringhuis,S.I., and Geijtenbeek,T.B. (2014). Measles Virus Suppresses RIG-I-like Receptor Activation in Dendritic Cells via DC-SIGN-Mediated Inhibition of PP1 Phosphatases. Cell Host Microbe 16, 31-42. . (IF 12.3)

5.   Gringhuis,S.I., Kaptein,T.M., Wevers,B.A., Theelen,B., van,d., V, Boekhout,T., and Geijtenbeek,T.B. (2012). Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1beta via a noncanonical caspase-8 inflammasome. Nat. Immunol. 13, 246-254; . (IF 26.2).

 

Patents

PCT/N100/00253 (DC-SIGN as target for immune regulation)

PCT/US99/16348 (Fucose carbohydrates to enhance antigen presentation).

PCT/NL2003/000781 (Malt inhibitors to treat T helper 17-mediated skin diseases).

EP08172072.4• (Inhibitors of Raf-1, MST1, MAVS and PLK1 for use in treatment of retrovirus infections)

 

Invited (keynote) lectures

During the last 10 years, I have given over 60 seminars in Europe, North America and Asia, and I have been invited to over 20 international conferences.

 

Research programmes

Prof. T.B.H. Geijtenbeek PhD (Dendritic cells in infection and immunity)

My research is focused on understanding the molecular mechanisms in dendritic cells (DCs) underlying immune responses to pathogens and cancer. Furthermore, he investigates the process of virus transmission (HIV-1, SARS-CoV-2, Zika and Dengue virus) by DC subsets using both in vitro DCs and ex vivo skin and vaginal mucosa models. We study the C-type lectin receptor DC-SIGN as an important receptor for pathogens and cancer cells and my recent research strongly suggest that DC-SIGN is important in the induction of effective adaptive immunity. We are currently investigating how DC-SIGN targeting can be used to increase anti-viral and anti-tumor immunity.  Moreover, we have identified C-type lectin receptor langerin as a HIV-1 receptor on human Langerhans cells that protects against HIV-1 infection. These data revealed an unexpected function for Langerhans cells in the innate defence against HIV-1. Further studies focus on how other viruses such as SARS-CoV-2, Zika and Dengue virus cause infection of the host and how DCs are involved in virus susceptibility. These studies provide insight into not only the role of DC subsets in the induction of effective antiviral and anti-tumor immunity but also how we can develop methods to harness C-type lectin receptors in vaccine development.

 

Faculty
P.A. Baars
S.I. Bouwman-Gringhuis PhD
E.M.M. van Leeuwen PhD

Postdocs
M. Bermejo-Jambrina
B.M. Nijmeijer MSc

Others
T.M. Kaptein BEng MSc
J.L. van Hamme BEng
E.M. Zijlstra-Willems BEng

Current research funding
  • AMC
  • AMC (Vrijgesteld)
  • Europese Unie
  • Life Sciences Health TKI
  • NWO
  • Stichting Aidsfonds/SOA AIDS Nederland
  • ZonMw
  • ZonMw (Vrijgesteld)