The Tytgat Institute for Liver and Intestinal Research within the AMC houses the fundamental and translational research in the field of hepatology and gastroenterology. Research in the Tytgat Institute is fundamental but usually built on a clinical question, aiming to provide results that can be translated into clinical practice. Extensive collaboration between physicians and researchers ensures a close link between the clinic and basic research. Similarly, multiple long-lasting public private partnerships have evolved demonstrating that our research is easily exploited. Research lines include metabolic and cholestatic liver disease, inflammatory bowel disease, microbiome, and early life nutrition. The institute has a strong involvement in the curriculum of Biomedical Sciences, and Medical School teaching programs.