Publications B.J.G. van den Boom
- Position
- PhD Candidate
- Main activities
- Research
- Specialisation
- Behavioral neuroscience
- Focus of research
I use head-mounted miniaturized microscopes combined with chronically implanted microendoscopes to image calcium signaling in vivo in striatal output neurons and midbrain dopamine neurons of freely-behaving rats to visualize how motivational behavior is encoded in the brain, specifically the shift from goal-directed to habitual behavior. In addition, I use this technique to image cellular activity in genetically engineered mice that show compulsive-like behaviors to understand the neuronal mechanisms of compulsivity that could potentially lead to a better understanding of psychiatric disorders such as addiction, OCD, and trichotillomania.
Amsterdam UMC Research Institutes
AMC departments
All publications
2020
- de Groot Andres, van den Boom Bastijn Jg, van Genderen Romano M., Coppens Joris, van Veldhuijzen John, Bos Joop, Hoedemaker Hugo, Negrello Mario, Willuhn Ingo, de Zeeuw Chris I., Hoogland Tycho M. NINscope, a versatile miniscope for multi-region circuit investigations eLife 2020;9 [PubMed]
2019
- van den Boom Bastijn J. G., Mooij Adriana H., Misevičiūtė Ieva, Denys Damiaan, Willuhn Ingo Behavioral flexibility in a mouse model for obsessive-compulsive disorder: Impaired Pavlovian reversal learning in SAPAP3 mutants: Impaired Pavlovian reversal learning in SAPAP3 mutants Genes, brain, and behavior 2019;18 (4):e12557 [PubMed]
2018
- Pinhal Cindy M., van den Boom Bastijn J. G., Santana-Kragelund Fabiana, Fellinger Lizz, Bech Pol, Hamelink Ralph, Feng Guoping, Willuhn Ingo, Feenstra Matthijs G. P., Denys Damiaan Differential Effects of Deep Brain Stimulation of the Internal Capsule and the Striatum on Excessive Grooming in Sapap3 Mutant Mice Biological psychiatry 2018;84 (12):917-925 [PubMed]
2017
- van den Boom Bastijn J. G., Pavlidi Pavlina, Wolf Casper M. H., Mooij Hanne A. H., Willuhn Ingo Automated classification of self-grooming in mice using open-source software Journal of neuroscience methods 2017;289:48-56 [PubMed]