C.A. Remme PhD publications

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Publications C.A. Remme PhD

Position
Associate Professor
Main activities
Research
Specialisation
Basic and translational cardiac electrophysiology
Focus of research
 
• Translational studies into cardiac sodium channel (dys)function and inherited sodium channelopathies (including SCN5A mutations) associated with cardiac arrhythmias and sudden cardiac death, incorporating clinical and genetic with functional and mechanistic studies in transgenic models and human induced pluripotent stem cell-derived (iPSC) cardiomyocytes.

• Basic studies aimed at (1) unraveling mechanisms by which defective sodium channels mediate cardiac conduction slowing and arrhythmogenesis, (2) the complexity of sodium channel function and regulation, and (3) their diverse (non-electrogenic) roles in cardiac structure and function.

• Identification of novel (genetic) determinants, modifiers and pathways mediating cardiac electrophysiology and arrhythmia risk.

• Translational studies aimed at identifying novel targets for the prevention and treatment of cardiac arrhythmias and sudden cardiac death.

 

 

2020

  • Casini Simona, Marchal Gerard A., Kawasaki Makiri, Nariswari Fransisca A., Portero Vincent, Guan Kaomei, Driessen Antoine H. G., Veldkamp Marieke W., Mengarelli Isabella, de Groot Joris R., Verkerk Arie O., Remme Carol Ann, van den Berg Nicoline W. E. Absence of Functional Nav1.8 Channels in Non-diseased Atrial and Ventricular Cardiomyocytes Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2020;33 (6):649-660 [PubMed]
  • van der Voorn Stephanie M., te Riele Anneline S. J. M., Basso Cristina, Calkins Hugh, Remme Carol Ann, van Veen Toon A. B. Arrhythmogenic cardiomyopathy: pathogenesis, pro-arrhythmic remodelling, and novel approaches for risk stratification and therapy Cardiovascular research 2020;116 (9):1571-1584 [PubMed]
  • Rivaud Mathilde R., Delmar Mario, Remme Carol Ann Heritable arrhythmia syndromes associated with abnormal cardiac sodium channel function: ionic and non-ionic mechanisms Cardiovascular research 2020;116 (9):1557-1570 [PubMed]
  • Priori Silvia G., Remme Carol Ann Inherited conditions of arrhythmia: translating disease mechanisms to patient management Cardiovascular research 2020;116 (9):1539-1541 [PubMed]
  • Wu Cheng-I., Postema Pieter G., Arbelo Elena, Behr Elijah R., Bezzina Connie R., Napolitano Carlo, Robyns Tomas, Probst Vincent, Schulze-Bahr Eric, Remme Carol Ann, Wilde Arthur A. M. SARS-CoV-2, COVID-19, and inherited arrhythmia syndromes Heart rhythm 2020;17 (9):1456-1462 [PubMed]
  • Marchal Gerard A., Verkerk Arie O., Mohan Rajiv A., Wolswinkel Rianne, Boukens Bastiaan J. D., Remme Carol A. The sodium channel NaV1.5 impacts on early murine embryonic cardiac development, structure and function in a non-electrogenic manner Acta physiologica (Oxford, England) 2020;230 (2) [PubMed]

2019

  • Cerrone Marina, Remme Carol Ann, Tadros Rafik, Bezzina Connie R., Delmar Mario Beyond the One Gene-One Disease Paradigm Circulation 2019;140 (7):595-610 [PubMed]
  • Verkerk Arie O, Remme Carol Ann Down the rabbit hole: deciphering the short QT syndrome European heart journal 2019;40 (10):854-856 [PubMed]
  • Kessler Elise L., van Stuijvenberg Leonie, van Bavel Joanne J. A., van Bennekom Joëlle, Zwartsen Anne, Rivaud Mathilde R., Vink Aryan, Efimov Igor R., Postma Alex V., van Tintelen J. Peter, Remme Carol A., Vos Marc A., Banning Antje, de Boer Teun P., Tikkanen Ritva, van Veen Toon A. B. Flotillins in the intercalated disc are potential modulators of cardiac excitability Journal of molecular and cellular cardiology 2019;126:86-95 [PubMed]
  • Casini Simona, Albesa Maxime, Wang Zizun, Portero Vincent, Ross-Kaschitza Daniela, Rougier Jean-S. bastien, Marchal Gerard A., Chung Wendy K., Bezzina Connie R., Abriel Hugues, Remme Carol Ann Functional consequences of the scn5a-p.Y1977n mutation within the py ubiquitylation motif: Discrepancy between hek293 cells and transgenic mice International journal of molecular sciences 2019;20 (20) [PubMed]
  • Verkerk Arie O., Remme Carol Ann 'Mature' resting membrane potentials in human-induced pluripotent stem cell-derived cardiomyocytes: Fact or artefact? EP Europace 2019;21 (12):1928 [PubMed]

2018

  • Rivaud Mathilde R., Jansen John A., Postema Pieter G., Nannenberg Eline A., Mizusawa Yuka, van der Nagel Roel, Wolswinkel Rianne, van der Made Ingeborg, Marchal Gerard A., Rajamani Sridharan, Belardinelli Luiz, van Tintelen J. Peter, Tanck Michael W. T., van DerWal Allard C., de Bakker Jacques M. T., van Rijen Harold V., Creemers Esther E., Wilde Arthur A. M., van den Berg Maarten P., van Veen Toon A. B., Bezzina Connie R., Remme Carol Ann A common co-morbiditymodulates disease expression and treatment efficacy in inherited cardiac sodiumchannelopathy European heart journal 2018;39 (31):2898-2907 [PubMed]
  • Verkerk Arie O., Amin Ahmad S., Remme Carol Ann Disease Modifiers of Inherited SCN5A Channelopathy Frontiers in cardiovascular medicine 2018;5 [PubMed]
  • Rivaud Mathilde Diversity and complexity of cardiac sodium channel (dys)function: Relevance for arrhythmias in inherited and acquired diseases 2018. ISBN 9789402810233. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Bezzina C. R.; Co-supervisors: Remme C. A., Creemers E. E. J. M.)
  • Rivaud Mathilde R., Baartscheer Antonius, Verkerk Arie O., Beekman Leander, Rajamani Sridharan, Belardinelli Luiz, Bezzina Connie R., Remme Carol Ann Enhanced late sodium current underlies pro-arrhythmic intracellular sodium and calcium dysregulation in murine sodium channelopathy International journal of cardiology 2018;263:54-62 [PubMed]
  • Boukens Bas J., Remme Carol Ann Intramural clefts and structural discontinuities in Brugada syndrome: the missing gap? Cardiovascular research 2018;114 (5):638-640 [PubMed]
  • Portero Vincent, Wilders Ronald, Casini Simona, Charpentier Flavien, Verkerk Arie O., Remme Carol Ann KV4.3 expression modulates NaV1.5 sodium current Frontiers in physiology 2018;9 (MAR) [PubMed]
  • Veldkamp Marieke W., Geuzebroek Guillaume S. C., Baartscheer Antonius, Verkerk Arie O., Schumacher Cees A., Suarez Gedeon G., Berger Wouter R., Casini Simona, van Amersfoorth Shirley C. M., Scholman Koen T., Driessen Antoine H. G., Belterman Charly N. W., van Ginneken Antoni C. G., de Groot Joris R., de Bakker Jacques M. T., Remme Carol Ann, Boukens Bas J., Coronel Ruben Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel Nature communications 2018;9 (1) [PubMed]
  • van den Hoogenhof Maarten M. G., Beqqali Abdelaziz, Amin Ahmad S., van der Made Ingeborg, Aufiero Simona, Khan Mohsin A. F., Schumacher Cees A., Jansweijer Joeri A., van Spaendonck-Zwarts Karin Y., Remme Carol Ann, Backs Johannes, Verkerk Arie O., Baartscheer Antonius, Pinto Yigal M., Creemers Esther E. RBM20 Mutations Induce an Arrhythmogenic Dilated Cardiomyopathy Related to Disturbed Calcium Handling Circulation 2018;138 (13):1330-1342 [PubMed]
  • Smits Anke M., Remme Carol Ann Scientists on the Spot: Carol Ann Remme on her research and career Cardiovascular research 2018;114 (13):e102 [PubMed]
  • Adriaens Michiel E., Lodder Elisabeth M., Moreno-Moral Aida, Silhavý Jan, Heinig Matthias, Glinge Charlotte, Belterman Charly, Wolswinkel Rianne, Petretto Enrico, Pravenec Michal, Remme Carol Ann, Bezzina Connie R. Systems genetics approaches in rat identify novel genes and gene networks associated with cardiac conduction Journal of the American Heart Association 2018;7 (21) [PubMed]
  • Wilde Arthur A. M., Remme Carol Ann Therapeutic approaches for Long QT syndrome type 3: an update Europace : European pacing, arrhythmias, and cardiac electrophysiology 2018;20 (2):222-224 [PubMed]

2017

  • Portero Vincent, Casini Simona, Hoekstra Maaike, Verkerk Arie O., Mengarelli Isabella, Belardinelli Luiz, Rajamani Sridharan, Wilde Arthur A. M., Bezzina Connie R., Veldkamp Marieke W., Remme Carol Ann Anti-arrhythmic potential of the late sodium current inhibitor GS-458967 in murine Scn5a-1798insD+/- and human SCN5A-1795insD+/- iPSC-derived cardiomyocytes Cardiovascular research 2017;113 (7):829-838 [PubMed]
  • Opthof Tobias, Remme Carol Ann, Jorge Esther, Noriega Francisco, Wiegerinck Rob F., Tasiam Arlin, Beekman Leander, Alvarez-Garcia Jesus, Munoz-Guijosa Cristian, Coronel Ruben, Cinca Juan Cardiac activation-repolarization patterns and ion channel expression mapping in intact isolated normal human hearts Heart rhythm 2017;14 (2):265-272 [PubMed]
  • Casini Simona, Verkerk Arie O., Remme Carol Ann Human iPSC-Derived Cardiomyocytes for Investigation of Disease Mechanisms and Therapeutic Strategies in Inherited Arrhythmia Syndromes: Strengths and Limitations Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2017;31 (3):325-344 [PubMed]
  • Veerman Christiaan C., Wilders Ronald, Wilde Arthur A., Coronel Ruben, Remme Carol Ann, Verkerk Arie O., Bezzina Connie R. Response by Veerman et al to Letter Regarding Article, "The Brugada Syndrome Susceptibility Gene HEY2 Modulates Cardiac Transmural Ion Channel Patterning and Electrical Heterogeneity" Circulation research 2017;121 (5):E21 [PubMed]
  • Rivaud Mathilde R., Agullo-Pascual Esperanza, Lin Xianming, Leo-Macias Alejandra, Zhang Mingliang, Rothenberg Eli, Bezzina Connie R., Delmar Mario, Remme Carol Ann Sodium Channel Remodeling in Subcellular Microdomains of Murine Failing Cardiomyocytes Journal of the American Heart Association 2017;6 (12):e007622 [PubMed]
  • Veerman Christiaan C., Podliesna Svitlana, Tadros Rafik, Lodder Elisabeth M., Mengarelli Isabella, de Jonge Berend, Beekman Leander, Barc Julien, Wilders Ronald, Wilde Arthur A., Boukens Bastiaan J., Coronel Ruben, Verkerk Arie, Remme Carol Ann, Bezzina Connie R. The Brugada Syndrome Susceptibility Gene HEY2 Modulates Cardiac Transmural Ion Channel Patterning and Electrical Heterogeneity Circulation research 2017;121 (5):537-548 [PubMed]

2016

  • Nicod Jérôme, Davies Robert W., Cai Na, Hassett Carl, Goodstadt Leo, Cosgrove Cormac, Yee Benjamin K., Lionikaite Vikte, McIntyre Rebecca E., Remme Carol Ann, Lodder Elisabeth M., Gregory Jennifer S., Hough Tertius, Joynson Russell, Phelps Hayley, Nell Barbara, Rowe Clare, Wood Joe, Walling Alison, Bopp Nasrin, Bhomra Amarjit, Hernandez-Pliego Polinka, Callebert Jacques, Aspden Richard M., Talbot Nick P., Robbins Peter A., Harrison Mark, Fray Martin, Launay Jean-Marie, Pinto Yigal M., Blizard David A., Bezzina Connie R., Adams David J., Franken Paul, Weaver Tom, Wells Sara, Brown Steve D. M., Potter Paul K., Klenerman Paul, Lionikas Arimantas, Mott Richard, Flint Jonathan Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing Nature genetics 2016;48 (8):912-918 [PubMed]

2015

  • Scicluna Brendon P., Remme Carol Ann, Rivaud Mathilde, Wilde Arthur A. M., Bezzina Connie R., Verkerk Arie O. Chemokine ligand 9 modulates cardiac repolarization via Cxcr3 receptor binding International journal of cardiology 2015;201:49-52 [PubMed]
  • Medzikovic Lejla, Schumacher Cees A., Verkerk Arie O., van Deel Elza D., Wolswinkel Rianne, van der Made Ingeborg, Bleeker Natascha, Cakici Daniella, van den Hoogenhof Maarten M. G., Meggouh Farid, Creemers Esther E., Remme Carol Ann, Baartscheer Antonius, de Winter Robbert J., de Vries Carlie J. M., Arkenbout E. Karin, de Waard Vivian Orphan nuclear receptor Nur77 affects cardiomyocyte calcium homeostasis and adverse cardiac remodelling Scientific reports 2015;5:15404 [PubMed]
  • Liu Gong Xin, Remme Carol Ann, Boukens Bastiaan J., Belardinelli Luiz, Rajamani Sridharan Overexpression of SCN5A in mouse heart mimics human syndrome of enhanced atrioventricular nodal conduction Heart rhythm 2015;12 (5):1036-1045 [PubMed]

2014

  • Marsman Roos F. J., Bezzina Connie R., Freiberg Fabian, Verkerk Arie O., Adriaens Michiel E., Podliesna Svitlana, Chen Chen, Purfürst Bettina, Spallek Bastian, Koopmann Tamara T., Baczko Istvan, dos Remedios Cristobal G., George Alfred L., Bishopric Nanette H., Lodder Elisabeth M., de Bakker Jacques M. T., Fischer Robert, Coronel Ruben, Wilde Arthur A. M., Gotthardt Michael, Remme Carol Ann Coxsackie and Adenovirus Receptor Is a Modifier of Cardiac Conduction and Arrhythmia Vulnerability in the Setting of Myocardial Ischemia Journal of the American College of Cardiology 2014;63 (6):549-559 [PubMed]
  • Marsman Roos F. J. Genetic risk factors for common and rare cardiac rhythm disorders 2014. 264p. ISBN 9789461086068. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Bezzina C. R., Wilde A. A. M.; Co-supervisors: Barnett P., Remme C. A.)
  • Shy Diana, Gillet Ludovic, Ogrodnik Jakob, Albesa Maxime, Verkerk Arie O., Wolswinkel Rianne, Rougier Jean-Sébastien, Barc Julien, Essers Maria C., Syam Ninda, Marsman Roos F., van Mil Anneke M., Rotman Samuel, Redon Richard, Bezzina Connie R., Remme Carol Ann, Abriel Hugues PDZ domain-binding motif regulates cardiomyocyte compartment-specific NaV1.5 channel expression and function Circulation 2014;130 (2):147-160 [PubMed]
  • Remme Carol Ann, Wilde Arthur A. M. Targeting sodium channels in cardiac arrhythmia Current opinion in pharmacology 2014;15:53-60 [PubMed]

2013

  • Zumhagen Sven, Veldkamp Marieke W., Stallmeyer Birgit, Baartscheer Antonius, Eckardt Lars, Paul Matthias, Remme Carol Ann, Bhuiyan Zahurul A., Bezzina Connie R., Schulze-Bahr Eric A heterozygous deletion mutation in the cardiac sodium channel gene SCN5A with loss- and gain-of-function characteristics manifests as isolated conduction disease, without signs of Brugada or long QT syndrome PLoS ONE 2013;8 (6):e67963 [PubMed]
  • Remme Carol Ann Cardiac sodium channelopathy associated with SCN5A mutations: electrophysiological, molecular and genetic aspects Journal of physiology 2013;591 (Part 17):4099-4116 [PubMed]
  • Bezzina Connie R., Barc Julien, Mizusawa Yuka, Remme Carol Ann, Gourraud Jean-Baptiste, Simonet Floriane, Verkerk Arie O., Schwartz Peter J., Crotti Lia, Dagradi Federica, Guicheney Pascale, Fressart Véronique, Leenhardt Antoine, Antzelevitch Charles, Bartkowiak Susan, Borggrefe Martin, Schimpf Rainer, Schulze-Bahr Eric, Zumhagen Sven, Behr Elijah R., Bastiaenen Rachel, Tfelt-Hansen Jacob, Olesen Morten Salling, Kääb Stefan, Beckmann Britt M., Weeke Peter, Watanabe Hiroshi, Endo Naoto, Minamino Tohru, Horie Minoru, Ohno Seiko, Hasegawa Kanae, Makita Naomasa, Nogami Akihiko, Shimizu Wataru, Aiba Takeshi, Froguel Philippe, Balkau Beverley, Lantieri Olivier, Torchio Margherita, Wiese Cornelia, Weber David, Wolswinkel Rianne, Coronel Ruben, Boukens Bas J., Bézieau Stéphane, Charpentier Eric, Chatel Stéphanie, Despres Aurore, Gros Françoise, Kyndt Florence, Lecointe Simon, Lindenbaum Pierre, Portero Vincent, Violleau Jade, Gessler Manfred, Tan Hanno L., Roden Dan M., Christoffels Vincent M., Le Marec Hervé, Wilde Arthur A., Probst Vincent, Schott Jean-Jacques, Dina Christian, Redon Richard Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death Nature genetics 2013;45 (9):1044-1049 [PubMed]
  • Bezzina Connie R., Barc Julien, Mizusawa Yuka, Remme Carol Ann, Gourraud Jean-Baptiste, Simonet Floriane, Verkerk Arie O., Schwartz Peter J., Crotti Lia, Dagradi Federica, Guicheney Pascale, Fressart Véronique, Leenhardt Antoine, Antzelevitch Charles, Bartkowiak Susan, Schulze-Bahr Eric, Zumhagen Sven, Behr Elijah R., Bastiaenen Rachel, Tfelt-Hansen Jacob, Olesen Morten Salling, Kääb Stefan, Beckmann Britt M., Weeke Peter, Watanabe Hiroshi, Endo Naoto, Minamino Tohru, Horie Minoru, Ohno Seiko, Hasegawa Kanae, Makita Naomasa, Nogami Akihiko, Shimizu Wataru, Aiba Takeshi, Froguel Philippe, Balkau Beverley, Lantieri Olivier, Torchio Margherita, Wiese Cornelia, Weber David, Wolswinkel Rianne, Coronel Ruben, Boukens Bas J., Bézieau Stéphane, Charpentier Eric, Chatel Stéphanie, Despres Aurore, Gros Françoise, Kyndt Florence, Lecointe Simon, Lindenbaum Pierre, Portero Vincent, Violleau Jade, Gessler Manfred, Tan Hanno L., Roden Dan M., Christoffels Vincent M., Le Marec Hervé, Wilde Arthur A., Probst Vincent, Schott Jean-Jacques, Dina Christian, Redon Richard Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death Nature genetics 2013;45 (11):1409 [PubMed]
  • Boukens Bas J., Hoogendijk Mark G., Verkerk Arie O., Linnenbank Andre, van Dam Peter, Remme Carol-Ann, Fiolet Jan W., Opthof Tobias, Christoffels Vincent M., Coronel Ruben Early repolarization in mice causes overestimation of ventricular activation time by the QRS duration Cardiovascular research 2013;97 (1):182-191 [PubMed]
  • Remme Carol Ann, Wilde Arthur A. M. Late sodium current inhibition in acquired and inherited ventricular (dys)function and arrhythmias Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2013;27 (1):91-101 [PubMed]
  • Boukens Bas J., Sylva Marc, de Gier-de Vries Corrie, Remme Carol Ann, Bezzina Connie R., Christoffels Vincent M., Coronel Ruben Reduced sodium channel function unmasks residual embryonic slow conduction in the adult right ventricular outflow tract Circulation research 2013;113 (2):137-141 [PubMed]
  • Remme Carol Ann Transgenic models of cardiac arrhythmias and sudden death Frontiers in physiology 2013;4:60 [PubMed]

2012

  • Davis Richard P., Casini Simona, van den Berg Cathelijne W., Hoekstra Maaike, Remme Carol Ann, Dambrot Cheryl, Salvatori Daniela, Ward-van Oostwaard Dorien, Wilde Arthur A. M., Bezzina Connie R., Verkerk Arie O., Freund Christian, Mummery Christine L. Cardiomyocytes Derived From Pluripotent Stem Cells Recapitulate Electrophysiological Characteristics of an Overlap Syndrome of Cardiac Sodium Channel Disease Circulation 2012;125 (25):3079-+ [PubMed]
  • Remme Carol Ann Connexin43 and Na(V)1.5: Partners in crime? Heart rhythm 2012;9 (4):608-609 [PubMed]
  • Lodder Elisabeth M., Scicluna Brendon P., Milano Annalisa, Sun Albert Y., Tang Hao, Remme Carol Ann, Moerland Perry D., Tanck Michael W. T., Pitt Geoffrey S., Marchuk Douglas A., Bezzina Connie R. Dissection of a Quantitative Trait Locus for PR Interval Duration Identifies Tnni3k as a Novel Modulator of Cardiac Conduction PLoS genetics 2012;8 (12):e1003113 [PubMed]
  • Hardziyenka Maxim, Campian Maria E., Verkerk Arie O., Surie Sulaiman, van Ginneken Antoni C. G., Hakim Sara, Linnenbank André C., de Bruin-Bon Rianne H. A. C. M., Beekman Leander, van der Plas Mart N., Remme Carol A., van Veen Toon A. B., Bresser Paul, de Bakker Jacques M. T., Tan Hanno L. Electrophysiologic Remodeling of the Left Ventricle in Pressure Overload-Induced Right Ventricular Failure Journal of the American College of Cardiology 2012;59 (24):2193-2202 [PubMed]
  • Verkerk Arie O., Remme Carol Ann, Schumacher Cees A., Scicluna Brendon P., Wolswinkel Rianne, de Jonge Berend, Bezzina Connie R., Veldkamp Marieke W. Functional Na(V)1.8 Channels in Intracardiac Neurons The Link Between SCN10A and Cardiac Electrophysiology Circulation research 2012;111 (3):333-343 [PubMed]
  • Rizzo Stefania, Lodder Elisabeth M., Verkerk Arie O., Wolswinkel Rianne, Beekman Leander, Pilichou Kalliopi, Basso Cristina, Remme Carol Ann, Thiene Gaetano, Bezzina Connie R. Intercalated disc abnormalities, reduced Na+ current density, and conduction slowing in desmoglein-2 mutant mice prior to cardiomyopathic changes Cardiovascular research 2012;95 (4):409-418 [PubMed]
  • Verkerk Arie O., Remme Carol Ann Zebrafish: a novel research tool for cardiac (patho)electrophysiology and ion channel disorders Frontiers in physiology 2012;3:UNSP 255 [PubMed]

2011

  • Scicluna Brendon P., Tanck Michael W. T., Remme Carol Ann, Beekman Leander, Coronel Ruben, Wilde Arthur A. M., Bezzina Connie R. Quantitative trait loci for electrocardiographic parameters and arrhythmia in the mouse Journal of molecular and cellular cardiology 2011;50 (3):380-389 [PubMed]
  • Hardziyenka Maxim, Campian Maria E., Reesink Herre J., Surie Sulaiman, Bouma Berto J., Groenink Maarten, Klemens Christine A., Beekman Leander, Remme Carol A., Bresser Paul, Tan Hanno L. Right ventricular failure following chronic pressure overload is associated with reduction in left ventricular mass: evidence for atrophic remodeling Journal of the American College of Cardiology 2011;57 (8):921-928 [PubMed]

2010

  • Remme Carol Ann, Bezzina Connie R. Cardiac desmosomal (dys)function and myocyte viability Cell cycle (Georgetown, Tex.) 2010;9 (7):1246-1252 [PubMed]
  • Remme Carol Ann, Bezzina Connie R. Sodium Channel (Dys)Function and Cardiac Arrhythmias Cardiovascular therapeutics 2010;28 (5):287-294 [PubMed]
  • Casini Simona, Tan Hanno L., Demirayak Ilker, Remme Carol Ann, Amin Ahmad S., Scicluna Brendon P., Chatyan Houssine, Ruijter Jan M., Bezzina Connie R., van Ginneken Antoni C. G., Veldkamp Marieke W. Tubulin polymerization modifies cardiac sodium channel expression and gating Cardiovascular research 2010;85 (4):691-700 [PubMed]

2009

  • Stein Mèra, van Veen Toon A. B., Remme Carol Ann, Boulaksil Mohamed, Noorman Maartje, van Stuijvenberg Leonie, van der Nagel Roel, Bezzina Connie R., Hauer Richard N. W., de Bakker Jacques M. T., van Rijen Harold V. M. Combined reduction of intercellular coupling and membrane excitability differentially affects transverse and longitudinal cardiac conduction Cardiovascular research 2009;83 (1):52-60 [PubMed]
  • Remme Carol Ann, Scicluna Brendon P., Verkerk Arie O., Amin Ahmad S., van Brunschot Sandra, Beekman Leander, Deneer Vera H. M., Chevalier Catherine, Oyama Fumitaka, Miyazaki Haruko, Nukina Nobuyuki, Wilders Ronald, Escande Denis, Houlgatte Remi, Wilde Arthur A. M., Tan Hanno L., Veldkamp Marieke W., de Bakker Jacques M. T., Bezzina Connie R. Genetically Determined Differences in Sodium Current Characteristics Modulate Conduction Disease Severity in Mice With Cardiac Sodium Channelopathy Circulation research 2009;104 (11):1283-U112 [PubMed]
  • Pilichou Kalliopi, Remme Carol Ann, Basso Cristina, Campian Maria E., Rizzo Stefania, Barnett Phil, Scicluna Brendon P., Bauce Barbara, van den Hoff Maurice J. B., de Bakker Jacques M. T., Tan Hanno L., Valente Marialuisa, Nava Andrea, Wilde Arthur A. M., Moorman Antoon F. M., Thiene Gaetano, Bezzina Connie R. Myocyte necrosis underlies progressive myocardial dystrophy in mouse dsg2-related arrhythmogenic right ventricular cardiomyopathy Journal of experimental medicine 2009;206 (8):1787-1802 [PubMed]
  • Remme C. A., Verkerk A. O., Hoogaars W. M. H., Aanhaanen W. T. J., Scicluna B. P., Annink C., van den Hoff M. J. B., Wilde A. A. M., van Veen T. A. B., Veldkamp M. W., de Bakker J. M. T., Christoffels V. M., Bezzina C. R. The cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium Basic research in cardiology 2009;104 (5):511-522 [PubMed]

2008

  • Remme Carol Ann, Wilde Arthur A. M., Bezzina Connie R. Cardiac sodium channel overlap syndromes: different faces of SCN5A mutations Trends in cardiovascular medicine 2008;18 (3):78-87 [PubMed]
  • Bezzina Connie R., Remme Carol Ann Dilated cardiomyopathy due to sodium channel dysfunction: what is the connection? Circulation. Arrhythmia and electrophysiology 2008;1 (2):80-82 [PubMed]
  • Remme Carol Ann, Wilde Arthur A. M. SCN5A overlap syndromes: no end to disease complexity? Europace : European pacing, arrhythmias, and cardiac electrophysiology 2008;10 (11):1253-1255 [PubMed]

2007

  • Remme C. A., Verkerk A. O., Wilde A. A. M., Veldkamp M. W., de Bakker J. M. T., Bezzina C. R. Diversity in cardiac sodium channel disease phenotype in transgenic mice carrying a single SCN5A mutation Netherlands heart journal 2007;15 (6):235-238 [PubMed]
  • Remme Carol Ann, Bezzina Connie R. Genetic modulation of cardiac repolarization reserve - Editorial commentary Heart rhythm 2007;4 (5):608-610 [PubMed]

2006

  • Remme Carol Ann, de Groot Gerrit H., Schrijver Gideon Diagnosis and treatment of VIPoma in a female patient European journal of gastroenterology & hepatology 2006;18 (1):93-99 [PubMed]
  • Remme Carol Ann, Verkerk Arie O., Nuyens Dieter, van Ginneken Antoni C. G., van Brunschot Sandra, Belterman Charly N. W., Wilders Ronald, van Roon Marian A., Tan Hanno L., Wilde Arthur A. M., Carmeliet Peter, de Bakker Jacques M. T., Veldkamp Marieke W., Bezzina Connie R. Overlap syndrome of cardiac sodium channel disease in mice carrying the equivalent mutation of human SCN5A-1795insD Circulation 2006;114 (24):2584-2594 [PubMed]
  • Wieling W., Remme C. A., van Dijk J. G. Transient loss of consciousness with muscle jerks: syncope or epilepsy?in: R. García-Civera, G. Barón-Esquivias, J. J. Blanc, M. Brignole, A. Moya i Mitjans, R. Ruiz-Granell, W. Wieling, editors. Syncope cases. Malden, MA: Blackwell Futura; 2006. p. 12-ev, ISBN 9781405151092

2002

  • Wilde A. A. M., Remme C. A., Derksen R., Wever E. F. D., Hauer R. N. W. Brugada syndrome European heart journal 2002;23 (8):675-676 [PubMed]
  • Smits Jeroen P. P., Eckardt Lars, Probst Vincent, Bezzina Connie R., Schott Jean Jacques, Remme Carol Ann, Haverkamp Wilhelm, Breithardt Günter, Escande Denis, Schulze-Bahr Eric, Lemarec Hervé, Wilde Arthur A. M. Genotype-phenotype relationship in Brugada syndrome: Electrocardiographic features differentiate SCN5A-related patients from non-SCN5A-related patients Journal of the American College of Cardiology 2002;40 (2):350-356 [PubMed]
  • Remme C. A. The ATP-sensitive potassium channel in the heart. Functional, electrophysiological and molecular aspects 2002. 207p. ISBN 9789090155982. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Wilde A. A. M., Moorman A. F. M.)

2001

  • Remme C. A., Lombardi M. P., van den Hoff M. J., Lekanne dit Deprez R. H. CDNA arrays: the ups and downs Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2001;15 (2):99-101 [PubMed]
  • Remme C. A., Wever E. F., Wilde A. A., Derksen R., Hauer R. N. Diagnosis and long-term follow-up of the Brugada syndrome in patients with idiopathic ventricular fibrillation European heart journal 2001;22 (5):400-409 [PubMed]
  • Remme C. A., Schumacher C. A., de Jong J. W., Fiolet J. W., de Groot J. R., Coronel R., Wilde A. A. K(ATP) channel opening during ischemia: effects on myocardial noradrenaline release and ventricular arrhythmias Journal of cardiovascular pharmacology 2001;38 (3):406-416 [PubMed]
  • de Groot J. R., Wilms-Schopman F. J., Opthof T., Remme C. A., Coronel R. Late ventricular arrhythmias during acute regional ischemia in the isolated blood perfused pig heart. Role of electrical cellular coupling Cardiovascular research 2001;50 (2):362-372 [PubMed]

2000

  • KATP channel openers, myocardial ischemia, and arrhythmias--should the electrophysiologist worry? Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2000;14 (1):17-22 [PubMed]

1999

  • A new, sympathetic look at KATP channels in the heart Cardiovascular research 1999;43 (1):17-19 [PubMed]

1995

  • Prediction of progression of radiologic damage in newly diagnosed rheumatoid arthritis Arthritis and rheumatism 1995;38 (10):1466-1474 [PubMed]

Corona-maatregelen

We zetten ons in om ons ziekenhuis veilig te houden tijdens de coronacrisis.

Lees deze extra maatregelen goed door voordat u een van onze locaties bezoekt: