D.J. Stenvers MD PhD publications

Publications MD PhD D.J. Stenvers

Position: Research Associate
Main activities: Patient care, Research
Specialisation: Endocrinology and metabolism
Focus of research: The circadian timing system consists of a central brain clock and peripheral clocks in metabolic organs such as liver, pancreas and adipose tissue. The circadian system receives direct information about light and darkness from the retina, and synchronises energy metabolism with the 24-hour rhythms of light/darkness and feeding/fasting. In present society, disruption of the circadian synchrony between the 24-hour rhythms of central and peripheral clocks, hormones, the autonomic nervous system, light/dark exposure, sleep/wake behaviour and food intake may contribute to the pandemic of obesity and type 2 diabetes. Dr. Stenvers' research focuses on the use of circadian knowledge to improve human metabolic health.

Amsterdam UMC Research Institutes

AMC departments

All publications

Muilwijk Mirthe, Stenvers Dirk Jan, Nicolaou Mary, Kalsbeek Andries, van Valkengoed Irene G. M. Behavioral Circadian Timing System Disruptors and Incident Type 2 Diabetes in a Nonshift Working Multi-Ethnic Population Obesity (Silver Spring, Md.) 2020;28 (S1):S55-S62 [PubMed]

Jan Stenvers Dirk, Scheer Frank A. J. L., Schrauwen Patrick, la Fleur Susanne E., Kalsbeek Andries Circadian clocks and insulin resistance Nature reviews. Endocrinology 2019;15 (2):75-89 [PubMed]
Milanova Irina V., Kalsbeek Martin J. T., Wang Xiao-Lan, Korpel Nikita L., Stenvers Dirk Jan, Wolff Samantha E. C., de Goede Paul, Heijboer Annemieke C., Fliers Eric, la Fleur Susanne E., Kalsbeek Andries, Yi Chun-Xia Diet-induced obesity disturbs microglial immunometabolism in a time-of-day manner Frontiers in endocrinology 2019;10 (JUN) [PubMed]
Stenvers Dirk Jan, Jongejan Aldo, Atiqi Sadaf, Vreijling Jeroen P., Limonard Eelkje J., Endert Erik, Baas Frank, Moerland Perry D., Fliers Eric, Kalsbeek Andries, Bisschop Peter H. Diurnal rhythms in the white adipose tissue transcriptome are disturbed in obese individuals with type 2 diabetes compared with lean control individuals Diabetologia 2019 [PubMed]

Versteeg Ruth I., Stenvers Dirk J., Visintainer Dana, Linnenbank Andre, Tanck Michael W., Zwanenburg Gooitzen, Smilde Age K., Fliers Eric, Kalsbeek Andries, Serlie Mireille J., la Fleur Susanne E., Bisschop Peter H. Acute Effects of Morning Light on Plasma Glucose and Triglycerides in Healthy Men and Men with Type 2 Diabetes Journal of biological rhythms 2017;32 (2):130-142 [PubMed]
Opperhuizen Anne-Loes, Stenvers Dirk J., Jansen Remi D., Foppen Ewout, Fliers Eric, Kalsbeek Andries Light at night acutely impairs glucose tolerance in a time-, intensity- and wavelength-dependent manner in rats Diabetologia 2017;60 (7):1333-1343 [PubMed]
Stenvers Dirk J. Light, the circadian timing system, and type 2 diabetes 2017. 219p. ISBN 9789402805451. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Fliers E., Kalsbeek A.; Co-supervisor: Bisschop P. H. L. T.)

Stenvers Dirk Jan, van Dorp Rick, Foppen Ewout, Mendoza Jorge, Opperhuizen Anne-Loes, Fliers Eric, Bisschop Peter H., Meijer Johanna H., Kalsbeek Andries, Deboer Tom Dim light at night disturbs the daily sleep-wake cycle in the rat Scientific reports 2016;6:35662 [PubMed]
Versteeg Ruth I., Stenvers Dirk J., Kalsbeek Andries, Bisschop Peter H., Serlie Mireille J., la Fleur Susanne E. Nutrition in the spotlight: metabolic effects of environmental light Proceedings of the Nutrition Society 2016;75 (4):451-463 [PubMed]

Stenvers Dirk J., Schouten Lydia J., Jurgens Jordy, Endert Erik, Kalsbeek Andries, Fliers Eric, Bisschop Peter H. Breakfast replacement with a low-glycaemic response liquid formula in patients with type 2 diabetes: a randomised clinical trial British journal of nutrition 2014;112 (4):504-512 [PubMed]

Stenvers Dirk Jan, DeVries J. Hans, la Fleur Susanne E. What's the Time? Does the Artificial Pancreas Need to Know? Diabetes 2013;62 (7):2173-2174 [PubMed]

Stenvers Dirk Jan, Jonkers Cora F., Fliers Eric, Bisschop Peter H. L. T., Kalsbeek Andries Nutrition and the circadian timing system Progress in brain research 2012;199:359-376 [PubMed]
Adriani Kirsten S., Stenvers Dirk J., Imanse Jaap G. Pearls & Oy-sters: Lumbar paraganglioma Can you see it in the eyes? Neurology 2012;78 (4):E27-E28 [PubMed]

Carter R. N., Paterson J. M., Tworowska U., Stenvers D. J., Mullins J. J., Seckl J. R., Holmes M. C. Hypothalamic-pituitary-adrenal axis abnormalities in response to deletion of 11beta-HSD1 is strain-dependent Journal of neuroendocrinology 2009;21 (11):879-887 [PubMed]

Lai Maggie, Horsburgh Karen, Bae Sung-Eun, Carter Roderick N., Stenvers Dirk J., Fowler Jill H., Yau Joyce L., Gomez-Sanchez Celso E., Holmes Megan C., Kenyon Christopher J., Seckl Jonathan R., Macleod Malcolm R. Forebrain mineralocorticoid receptor overexpression enhances memory, reduces anxiety and attenuates neuronal loss in cerebral ischaemia European journal of neuroscience 2007;25 (6):1832-1842 [PubMed]

Tas Sander W., Hajji Najat, Stenvers Dirk J., Firestein Gary S., Vervoordeldonk Margriet J., Tak Paul P. Reduction of proinflammatory cytokine expression in the synovium by targeting IKKbeta in vivo in a rat model Arthritis and rheumatism 2006;54 (11):3716-3718 [PubMed]