E.M. Lodder PhD publications

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Publications PhD E.M. Lodder

Position
Assistant Professor
Main activities
Research
Specialisation
Molecular Genetics of Cardiac Arrhythmias
Focus of research

Identification of genetic determinants and modifiers of cardiac arrhythmias and sudden cardiac death.

2021

  • Mazzarotto Francesco, Hawley Megan H., Beltrami Matteo, Beekman Leander, de Marvao Antonio, McGurk Kathryn A., Statton Ben, Boschi Beatrice, Girolami Francesca, Roberts Angharad M., Lodder Elisabeth M., Allouba Mona, Romeih Soha, Aguib Yasmine, Baksi A. John, Pantazis Antonis, Prasad Sanjay K., Cerbai Elisabetta, Yacoub Magdi H., O’Regan Declan P., Cook Stuart A., Ware James S., Funke Birgit, Olivotto Iacopo, Bezzina Connie R., Barton Paul J. R., Walsh Roddy Systematic large-scale assessment of the genetic architecture of left ventricular noncompaction reveals diverse etiologies Genetics in medicine 2021 [PubMed]

2020

  • Wilde Arthur A. M., Lodder Elisabeth M. A highly specific biomarker for Brugada syndrome. Also too good to be true? European heart journal 2020;41 (28):2891-2893 [PubMed]
  • Wilde Arthur A. M., Lodder Elisabeth M. Biomarkers in inherited arrhythmias: necessity for validation and collaboration European heart journal 2020;41 (47):4523-4524 [PubMed]
  • Glinge Charlotte, Engstrøm Thomas, Midgley Sofie E., Tanck Michael W. T., Madsen Jeppe Ekstrand Halkjær, Pedersen Frants, Jacobsen Mia Ravn, Lodder Elisabeth M., Al-Hussainy Nour R., Stampe Niels Kjær, Trebbien Ramona, Køber Lars, Gerds Thomas, Torp-Pedersen Christian, Fischer Thea K. lsen, Bezzina Connie R., Tfelt-Hansen Jacob, Jabbari Reza Erratum: Seasonality of ventricular fibrillation at first myocardial infarction and association with viral exposure (PLoS ONE (2020)15:2(e0226936)Doi: 10.1371/journal.pone.0226936) PLoS ONE 2020;15 (4) [PubMed]
  • Scholman Koen T., Meijborg Veronique M.F., Gálvez-Montón Carolina, Lodder Elisabeth M., Boukens Bastiaan J. From Genome-Wide Association Studies to Cardiac Electrophysiology: Through the Maze of Biological Complexity: Through the Maze of Biological Complexity Frontiers in physiology 2020;11 [PubMed]
  • Brosens Erwin, Felix Janine F., Boerema-de Munck Anne, de Jong Elisabeth M., Lodder Elisabeth M., Swagemakers Sigrid, Buscop-van Kempen Marjon, de Krijger Ronald R., Wijnen Rene M. H., van IJcken Wilfred F. J., van der Spek Peter, de Klein Annelies, Tibboel Dick, Rottier Robbert J. Histological, immunohistochemical and transcriptomic characterization of human tracheoesophageal fistulas PLoS ONE 2020;15 (11 November) [PubMed]
  • Glinge Charlotte, Engstrøm Thomas, Midgley Sofie E., Tanck Michael W. T., Halkjær Madsen Jeppe Ekstrand, Pedersen Frants, Jacobsen Mia Ravn, Lodder Elisabeth M., Al-Hussainy Nour R., Stampe Niels Kjær, Trebbien Ramona, Køber Lars, Gerds Thomas, Torp-Pedersen Christian, Fischer Thea K. lsen, Bezzina Connie R., Tfelt-Hansen Jacob, Jabbari Reza Seasonality of ventricular fibrillation at first myocardial infarction and association with viral exposure PLoS ONE 2020;15 (2) [PubMed]
  • Lahrouchi Najim, Raju Hariharan, Lodder Elisabeth M., Papatheodorou Stathis, Miles Chris, Ware James S., Papadakis Michael, Tadros Rafik, Cole Della, Skinner Jonathan R., Crawford Jackie, Love Donald R., Pua Chee J., Soh Bee Y., Bhalshankar Jaydutt D., Govind Risha, Tfelt-Hansen Jacob, Winkel Bo G., van der Werf Christian, Wijeyeratne Yanushi D., Mellor Greg, Till Janice, Cohen Marta, Tome-Esteban Maria, Sharma Sanjay, Wilde Arthur A. M., Cook Stuart A., Sheppard Mary N., Bezzina Connie R., Behr Elijah R. The yield of postmortem genetic testing in sudden death cases with structural findings at autopsy European journal of human genetics 2020;28 (1):17-22 [PubMed]

2019

  • Roberts Jason D., Murphy Nathaniel P., Hamilton Robert M., Lubbers Ellen R., James Cynthia A., Kline Crystal F., Gollob Michael H., Krahn Andrew D., Sturm Amy C., Musa Hassan, el-Refaey Mona, Koenig Sara, Aneq Meriam Åström, Hoorntje Edgar T., Graw Sharon L., Davies Robert W., Rafiq Muhammad Arshad, Koopmann Tamara T., Aafaqi Shabana, Fatah Meena, Chiasson David A., Taylor Matthew Rg, Simmons Samantha L., Han Mei, van Opbergen Chantal Jm, Wold Loren E., Sinagra Gianfranco, Mittal Kirti, Tichnell Crystal, Murray Brittney, Codima Alberto, Nazer Babak, Nguyen Duy T., Marcus Frank I., Sobriera Nara, Lodder Elisabeth M., van den Berg Maarten P., Spears Danna A., Robinson John F., Ursell Philip C., Green Anna K., Skanes Allan C., Tang Anthony S., Gardner Martin J., Hegele Robert A., van Veen Toon Ab, Wilde Arthur A. M., Healey Jeff S., Janssen Paul M. L., Mestroni Luisa, van Tintelen J. Peter, Calkins Hugh, Judge Daniel P., Hund Thomas J., Scheinman Melvin M., Mohler Peter J. Ankyrin-B dysfunction predisposes to arrhythmogenic cardiomyopathy and is amenable to therapy Journal of clinical investigation 2019;130:3171-3184 [PubMed]
  • Verkerk Arie O., Lodder Elisabeth M., Wilders Ronald Aquaporin Channels in the Heart-Physiology and Pathophysiology International journal of molecular sciences 2019;20 (8):20139 [PubMed]
  • Škorić-Milosavljević Doris, Tjong Fleur V. Y., Barc Julien, Backx Ad P. C. M., Clur Sally-Ann B., van Spaendonck-Zwarts Karin, Oostra Roelof-Jan, Lahrouchi Najim, Beekman Leander, Bökenkamp Regina, Barge-Schaapveld Daniela Q. C. M., Mulder Barbara J., Lodder Elisabeth M., Bezzina Connie R., Postma Alex V. GATA6 mutations: Characterization of two novel patients and a comprehensive overview of the GATA6 genotypic and phenotypic spectrum American journal of medical genetics. Part A 2019;179 (9):1836-1845 [PubMed]
  • Veerman Christiaan C., Mengarelli Isabella, Koopman Charlotte D., Wilders Ronald, van Amersfoorth Shirley C., Bakker Diane, Wolswinkel Rianne, Hababa Mariam, de Boer Teun P., Guan Kaomei, Milnes James, Lodder Elisabeth M., Bakkers Jeroen, Verkerk Arie O., Bezzina Connie R. Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current (IK,ACh) Disease models & mechanisms 2019;12 (7) [PubMed]
  • Lahrouchi Najim, George Aman, Ratbi Ilham, Schneider Ronen, Elalaoui Siham C, Moosa Shahida, Bharti Sanita, Sharma Ruchi, Abu-Asab Mones, Onojafe Felix, Adadi Najlae, Lodder Elisabeth M, Laarabi Fatima-Zahra, Lamsyah Yassine, Elorch Hamza, Chebbar Imane, Postma Alex V, Lougaris Vassilios, Plebani Alessandro, Altmueller Janine, Kyrieleis Henriette, Meiner Vardiella, McNeill Helen, Bharti Kapil, Lyonnet Stanislas, Wollnik Bernd, Henrion-Caude Alexandra, Berraho Amina, Hildebrandt Friedhelm, Bezzina Connie R, Brooks Brian P, Sefiani Abdelaziz Homozygous frameshift mutations in FAT1 cause a syndrome characterized by colobomatous-microphthalmia, ptosis, nephropathy and syndactyly Nature communications 2019;10 (1):1180 [PubMed]
  • Podliesna Svitlana, Delanne Julian, Miller Lindsey, Tester David J., Uzunyan Merujan, Yano Shoji, Klerk Mischa, Cannon Bryan C., Khongphatthanayothin Apichai, Laurent Gabriel, Bertaux Geraldine, Falcon-Eicher Sylvie, Wu Shengnan, Yen Hai-Yun, Gao Hanlin, Wilde Arthur A. M., Faivre Laurence, Ackerman Michael J., Lodder Elisabeth M., Bezzina Connie R. Supraventricular tachycardias, conduction disease, and cardiomyopathy in 3 families with the same rare variant in TNNI3K (p.Glu768Lys) Heart rhythm 2019;16 (1):98-105 [PubMed]

2018

  • Bundgaard Henning, Jøns Christian, Lodder Elisabeth M., Izarzugaza Jose M. G., Romero Herrera Jose A., Pehrson Steen, Tfelt-Hansen Jacob, Ahlberg Gustav, Olesen Morten S., Holst Anders G., Wellens Hein, de Villiers Carin, Hastings Robert, Stuart Graham, Brunak S. ren, Wilde Arthur A. M., Watkins Hugh, Christensen Alex H. A Novel Familial Cardiac Arrhythmia Syndrome with Widespread ST-Segment Depression New England journal of medicine 2018;379 (18):1780-1781 [PubMed]
  • Vermeer Alexa M. C., Christiaans Imke, Lodder Elisabeth M. Letter by Vermeer et al Regarding Article, "Phenotypic Spectrum of HCN4 Mutations: A Clinical Case" Circulation. Genomic and precision medicine 2018;11 (5):e002160 [PubMed]
  • Adriaens Michiel E., Lodder Elisabeth M., Moreno-Moral Aida, Silhavý Jan, Heinig Matthias, Glinge Charlotte, Belterman Charly, Wolswinkel Rianne, Petretto Enrico, Pravenec Michal, Remme Carol Ann, Bezzina Connie R. Systems genetics approaches in rat identify novel genes and gene networks associated with cardiac conduction Journal of the American Heart Association 2018;7 (21) [PubMed]

2017

  • Podliesna Svitlana, Bezzina Connie R., Lodder Elisabeth M. Complex Genetics of Cardiovascular Traits in Mice: F2-Mapping of QTLs and Their Underlying Genes Methods in molecular biology (Clifton, N.J.) 2017;1488:431-454 [PubMed]
  • Lahrouchi Najim, Lodder Elisabeth M., Mansouri Maria, Tadros Rafik, Zniber Layla, Adadi Najlae, Clur Sally-Ann B., van Spaendonck-Zwarts Karin Y., Postma Alex V., Sefiani Abdelaziz, Ratbi Ilham, Bezzina Connie R. Exome sequencing identifies primary carnitine deficiency in a family with cardiomyopathy and sudden death European journal of human genetics 2017;25 (6):783-787 [PubMed]
  • Vermeer Alexa M., Lodder Elisabeth M., Christiaans Imke, van Langen Irene M., Wilde Arthur A., Bezzina Connie R., Tadros Rafik Familial Disease Is Not Always Genetic: A Family With Atrioventricular Block and Mitral Regurgitation Canadian journal of cardiology 2017;33 (4):554.e9-554.e11 [PubMed]
  • Lieve Krystien V., Verkerk Arie O., Podliesna Svitlana, van der Werf Christian, Tanck Michael W., Hofman Nynke, van Bergen Paul F., Beekman Leander, Bezzina Connie R., Wilde Arthur A. M., Lodder Elisabeth M. Gain-of-function mutation in SCN5A causes ventricular arrhythmias and early onset atrial fibrillation International journal of cardiology 2017;236:187-193 [PubMed]
  • Lodder Elisabeth M., Verkerk Arie O., Bezzina Connie R. G-Protein beta Subunit Mutations in Sinus Node Dysfunction Circulation research 2017;120 (10):1524-1526 [PubMed]
  • Heinig Matthias, Adriaens Michiel E., Schafer Sebastian, van Deutekom Hanneke W. M., Lodder Elisabeth M., Ware James S., Schneider Valentin, Felkin Leanne E., Creemers Esther E., Meder Benjamin, Katus Hugo A., Rühle Frank, Stoll Monika, Cambien François, Villard Eric, Charron Philippe, Varro Andras, Bishopric Nanette H., George Alfred L., Dos Remedios Cristobal, Moreno-Moral Aida, Pesce Francesco, Bauerfeind Anja, Rüschendorf Franz, Rintisch Carola, Petretto Enrico, Barton Paul J., Cook Stuart A., Pinto Yigal M., Bezzina Connie R., Hubner Norbert Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy Genome biology 2017;18 (1) [PubMed]
  • Veerman Christiaan C., Mengarelli Isabella, Lodder Elisabeth M., Kosmidis Georgios, Bellin Milena, Zhang Miao, Dittmann Sven, Guan Kaomei, Wilde Arthur A. M., Schulze-Bahr Eric, Greber Boris, Bezzina Connie R., Verkerk Arie O. Switch From Fetal to Adult SCN5A Isoform in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Unmasks the Cellular Phenotype of a Conduction Disease-Causing Mutation Journal of the American Heart Association 2017;6 (7) [PubMed]
  • Veerman Christiaan C., Podliesna Svitlana, Tadros Rafik, Lodder Elisabeth M., Mengarelli Isabella, de Jonge Berend, Beekman Leander, Barc Julien, Wilders Ronald, Wilde Arthur A., Boukens Bastiaan J., Coronel Ruben, Verkerk Arie, Remme Carol Ann, Bezzina Connie R. The Brugada Syndrome Susceptibility Gene HEY2 Modulates Cardiac Transmural Ion Channel Patterning and Electrical Heterogeneity Circulation research 2017;121 (5):537-548 [PubMed]
  • Lahrouchi Najim, Raju Hariharan, Lodder Elisabeth M., Papatheodorou Efstathios, Ware James S., Papadakis Michael, Tadros Rafik, Cole Della, Skinner Jonathan R., Crawford Jackie, Love Donald R., Pua Chee J., Soh Bee Y., Bhalshankar Jaydutt D., Govind Risha, Tfelt-Hansen Jacob, Winkel Bo G., van der Werf Christian, Wijeyeratne Yanushi D., Mellor Greg, Till Jan, Cohen Marta C., Tome-Esteban Maria, Sharma Sanjay, Wilde Arthur A. M., Cook Stuart A., Bezzina Connie R., Sheppard Mary N., Behr Elijah R. Utility of Post-Mortem Genetic Testing in Cases of Sudden Arrhythmic Death Syndrome Journal of the American College of Cardiology 2017;69 (17):2134-2145 [PubMed]

2016

  • Vermeer Alexa M. C., Lodder Elisabeth M., Thomas Dierk, Duijkers Floor A. M., Marcelis Carlo, van Gorselen Edwin O. F., Fortner Philipp, Buss Sebastian J., Mereles Derliz, Katus Hugo A., Wilde Arthur A. M., Bezzina Connie R., Boekholdt S. Matthijs, Schweizer Patrick A., Christiaans Imke Dilation of the Aorta Ascendens Forms Part of the Clinical Spectrum of HCN4 Mutations Journal of the American College of Cardiology 2016;67 (19):2313-2315 [PubMed]
  • Nicod Jérôme, Davies Robert W., Cai Na, Hassett Carl, Goodstadt Leo, Cosgrove Cormac, Yee Benjamin K., Lionikaite Vikte, McIntyre Rebecca E., Remme Carol Ann, Lodder Elisabeth M., Gregory Jennifer S., Hough Tertius, Joynson Russell, Phelps Hayley, Nell Barbara, Rowe Clare, Wood Joe, Walling Alison, Bopp Nasrin, Bhomra Amarjit, Hernandez-Pliego Polinka, Callebert Jacques, Aspden Richard M., Talbot Nick P., Robbins Peter A., Harrison Mark, Fray Martin, Launay Jean-Marie, Pinto Yigal M., Blizard David A., Bezzina Connie R., Adams David J., Franken Paul, Weaver Tom, Wells Sara, Brown Steve D. M., Potter Paul K., Klenerman Paul, Lionikas Arimantas, Mott Richard, Flint Jonathan Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing Nature genetics 2016;48 (8):912-918 [PubMed]
  • Lodder Elisabeth M., de Nittis Pasquelena, Koopman Charlotte D., Wiszniewski Wojciech, Moura de Souza Carolina Fischinger, Lahrouchi Najim, Guex Nicolas, Napolioni Valerio, Tessadori Federico, Beekman Leander, Nannenberg Eline A., Boualla Lamiae, Blom Nico A., de Graaff Wim, Kamermans Maarten, Cocciadiferro Dario, Malerba Natascia, Mandriani Barbara, Akdemir Zeynep Hande Coban, Fish Richard J., Eldomery Mohammad K., Ratbi Ilham, Wilde Arthur A. M., de Boer Teun, Simonds William F., Neerman-Arbez Marguerite, Sutton V. Reid, Kok Fernando, Lupski James R., Reymond Alexandre, Bezzina Connie R., Bakkers Jeroen, Merla Giuseppe GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability American journal of human genetics 2016;99 (3):704-710 [PubMed]
  • Lodder Elisabeth M. Introducing Genetics - 2nd Edition European journal of human genetics 2016;24 (6):954 [PubMed]
  • Milano Annalisa, Blom Marieke T., Lodder Elisabeth M., van Hoeijen Daniel A., Barc Julien, Koopmann Tamara T., Bardai Abdennasser, Beekman Leander, Lichtner Peter, van den Berg Maarten P., Wilde Arthur A. M., Bezzina Connie R., Tan Hanno L. Sudden Cardiac Arrest and Rare Genetic Variants in the Community Circulation. Cardiovascular genetics 2016;9 (2):147-153 [PubMed]

2015

  • Veerman Christiaan C., Wilde Arthur A. M., Lodder Elisabeth M. The cardiac sodium channel gene SCN5A and its gene product NaV1.5: Role in physiology and pathophysiology Gene 2015;573 (2):177-187 [PubMed]
  • Milano Annalisa, Lodder Elisabeth M., Bezzina Connie R. TNNI3K in cardiovascular disease and prospects for therapy Journal of molecular and cellular cardiology 2015;82:167-173 [PubMed]
  • Milano Annalisa Understanding cardiac electrical phenotypes in the genomic era 2015. 164p. ISBN 9789462951044. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Bezzina C. R.; Co-supervisor: Lodder E. M.)

2014

  • Marsman Roos F. J., Bezzina Connie R., Freiberg Fabian, Verkerk Arie O., Adriaens Michiel E., Podliesna Svitlana, Chen Chen, Purfürst Bettina, Spallek Bastian, Koopmann Tamara T., Baczko Istvan, dos Remedios Cristobal G., George Alfred L., Bishopric Nanette H., Lodder Elisabeth M., de Bakker Jacques M. T., Fischer Robert, Coronel Ruben, Wilde Arthur A. M., Gotthardt Michael, Remme Carol Ann Coxsackie and Adenovirus Receptor Is a Modifier of Cardiac Conduction and Arrhythmia Vulnerability in the Setting of Myocardial Ischemia Journal of the American College of Cardiology 2014;63 (6):549-559 [PubMed]
  • Koopmann Tamara T., Adriaens Michiel E., Moerland Perry D., Marsman Roos F., Westerveld Margriet L., Lal Sean, Zhang Taifang, Simmons Christine Q., Baczko Istvan, Dos Remedios Cristobal, Bishopric Nanette H., Varro Andras, George Alfred L., Lodder Elisabeth M., Bezzina Connie R. Genome-wide identification of expression quantitative trait loci (eQTLs) in human heart PLoS ONE 2014;9 (5):e97380 [PubMed]
  • Lodder Elisabeth M., Bezzina Connie R. Genomics of cardiac electrical function Briefings in functional genomics 2014;13 (1):39-50 [PubMed]
  • Milano Annalisa, Vermeer Alexa M. C., Lodder Elisabeth M., Barc Julien, Verkerk Arie O., Postma Alex V., van der Bilt Ivo A. C., Baars Marieke J. H., van Haelst Paul L., Caliskan Kadir, Hoedemaekers Yvonne M., Le Scouarnec Solena, Redon Richard, Pinto Yigal M., Christiaans Imke, Wilde Arthur A., Bezzina Connie R. HCN4 mutations in multiple families with bradycardia and left ventricular noncompaction cardiomyopathy Journal of the American College of Cardiology 2014;64 (8):745-756 [PubMed]
  • Lodder Elisabeth M., Scicluna Brendon P., Beekman Leander, Arends Danny, Moerland Perry D., Tanck Michael W. T., Adriaens Michiel E., Bezzina Connie R. Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition Circulation. Cardiovascular genetics 2014;7 (6):790-798 [PubMed]

2013

  • Lodder Elisabeth M., Bezzina Connie R. Arrhythmogenic right ventricular cardiomyopathy: growing evidence for complex inheritance Circulation. Cardiovascular genetics 2013;6 (6):525-527 [PubMed]

2012

  • Lodder Elisabeth M., Wilde Arthur A. M. Clinical Assessment of the Pathogenicity of Unknown Variants in Long-QT Syndrome: Does the Pendulum Swing Back? Journal of cardiovascular electrophysiology 2012;23 (6):643-644 [PubMed]
  • Lodder Elisabeth M., Scicluna Brendon P., Milano Annalisa, Sun Albert Y., Tang Hao, Remme Carol Ann, Moerland Perry D., Tanck Michael W. T., Pitt Geoffrey S., Marchuk Douglas A., Bezzina Connie R. Dissection of a Quantitative Trait Locus for PR Interval Duration Identifies Tnni3k as a Novel Modulator of Cardiac Conduction PLoS genetics 2012;8 (12):e1003113 [PubMed]
  • Rizzo Stefania, Lodder Elisabeth M., Verkerk Arie O., Wolswinkel Rianne, Beekman Leander, Pilichou Kalliopi, Basso Cristina, Remme Carol Ann, Thiene Gaetano, Bezzina Connie R. Intercalated disc abnormalities, reduced Na+ current density, and conduction slowing in desmoglein-2 mutant mice prior to cardiomyopathic changes Cardiovascular research 2012;95 (4):409-418 [PubMed]
  • Lodder Elisabeth M., Rizzo Stefania Mouse models in arrhythmogenic right ventricular cardiomyopathy Frontiers in physiology 2012;3:UNSP 221 [PubMed]

2009

  • Lodder Elisabeth M., Eussen Bert H., van Hassel Daniëlla A. C. M., Hoogeboom A. Jeannette M., Poddighe Pino J., Coert J. Henk, Oostra Ben A., de Klein Annelies, de Graaff Esther Implication of long-distance regulation of the HOXA cluster in a patient with postaxial polydactyly Chromosome research 2009;17 (6):737-744 [PubMed]

2008

  • Lodder E. M., Hoogeboom A. J. M., Coert J. H., de Graaff E. Deletion of 1 amino acid in Indian hedgehog leads to brachydactylyA1 American journal of medical genetics. Part A 2008;146A (16):2152-2154 [PubMed]
  • van Gils Walter, Lodder Elisabeth M., Mensink Hanneke W., Kiliç Emine, Naus Nicole C., Brüggenwirth Hennie T., van Ijcken Wilfred, Paridaens Dion, Luyten Gregorius P., de Klein Annelies Gene expression profiling in uveal melanoma: two regions on 3p related to prognosis Investigative ophthalmology & visual science 2008;49 (10):4254-4262 [PubMed]

2006

  • Kilic Emine, van Gils Walter, Lodder Elisabeth, Beverloo H. Berna, van Til Marjan E., Mooy Cornelia M., Paridaens Dion, de Klein Annelies, Luyten Gregorius P. M. Clinical and cytogenetic analyses in uveal melanoma Investigative ophthalmology & visual science 2006;47 (9):3703-3707 [PubMed]