H.J.G.D. van den Bongard MD PhD publications

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Publications MD PhD H.J.G.D. van den Bongard

Position
Medical Specialist
Main activities
Patient care, Research
Specialisation
Radiation oncology; with focus on breast cancer, MR-guided radiotherapy, hyperthermia, oligometastases.
Focus of research

Dr. van den Bongards research is focussed on de-escalation of treatment and decreased treatment-induced morbidity in breast cancer patients with the aim to optimize quality of life after treatment.

Her main focus in research is the clinical introduction of treatment with one single-dose pre-operative MR-guided Partial Breast Irradiation (PBI) in low-risk breast cancer patients (instead of standard post-operative partial or whole breast irradiation during 2 to 5 weeks).

Pre-operative instead of post-operative PBI has the potential to further decrease radiotherapy-induced toxicity and improve quality of life due to irradiation of smaller target volumes and reduced organs at risk volumes. Pre-operative PBI offers the possibility for response monitoring using imaging, and evaluation of response markers in blood and tumor tissue compared to the standard postoperative irradiation. In addition, pre-operative PBI has the potential to greatly reduce the treatment burden if the pathologic complete response can be accurately predicted, and would allow omitting breast-conserving surgery. Moreover, patients that would still require BCS would benefit from a single dose of pre-operative PBI instead of 2 to 5 weeks of postoperative irradiation in the current standard of care. 

The clinical feasibility of pre-operative irradiation with one single dose followed by breast-conserving surgery 6 to 8 month after irradiation has been proven in a multicenter study that showed a pathologic complete response in more than 40% of the patients. In the recent future, the ABLATIVE-2 trial will be initiated to study the response at 1 year after pre-operative PBI including potential response predictors in these patients.

 

 

Amsterdam UMC Research Institutes
AMC departments
All publications

2021

  • Vasmel Jeanine E., Vreuls Celien P. H., Manson Quirine F., Charaghvandi Ramona K., van Gorp Joost, van Leeuwen A. M. Gijs, van Diest Paul J., Verkooijen Helena M., van den Bongard H. J. G. Desiree Tumor-Infiltrating Lymphocytes in Low-Risk Patients With Breast Cancer Treated With Single-Dose Preoperative Partial Breast Irradiation International journal of radiation oncology, biology, physics 2021 [PubMed]

2020

  • Batenburg M. C. T., van den Bongard H. J. G. D., Kleynen C. E., Maarse W., Witkamp A., Ernst M., Doeksen A., van Dalen T., Sier M., Schoenmaeckers E. J. P., Baas I. O., Verkooijen H. M. Assessing the effect of hyperbaric oxygen therapy in breast cancer patients with late radiation toxicity (HONEY trial): a trial protocol using a trial within a cohort design Trials 2020;21 (1) [PubMed]
  • Gregorowitsch Madelijn L., van den Bongard Desirée H. J. G., Batenburg Marilot C. T., Traa-van de Grootevheen Marieke J. C., Fuhler Nick, van Het Westeinde Tanja, van der Pol Carmen C., Young-Afat Danny A., Verkooijen Helena M. Compression Vest Treatment for Symptomatic Breast Edema in Women Treated for Breast Cancer: A Pilot Study Lymphatic research and biology 2020;18 (1):56-63 [PubMed]
  • Vasmel Jeanine E., Groot Koerkamp Maureen L., Kirby Anna M., Russell Nicola S., Shaitelman Simona F., Vesprini Danny, Anandadas Carmel N., Currey Adam, Keller Brian M., Braunstein Lior Z., Han Kathy, Kotte Alexis N. T. J., de Waard Stephanie N., Philippens Marielle E. P., Houweling Antonetta C., Verkooijen Helena M., van den Bongard H. J. G. Desiree Consensus on Contouring Primary Breast Tumors on MRI in the Setting of Neoadjuvant Partial Breast Irradiation in Trials Practical radiation oncology 2020;10 (6):e466-e474 [PubMed]
  • van Velzen Sanne G. M., Lessmann Nikolas, Velthuis Birgitta K., Bank Ingrid E. M., van den Bongard Desiree H. J. G., Leiner Tim, de Jong Pim A., Veldhuis Wouter B., Correa Adolfo, Terry James G., Carr John Jeffrey, Viergever Max A., Verkooijen Helena M., Išgum Ivana Deep learning for automatic calcium scoring in CT: Validation using multiple cardiac CT and chest CT protocols Radiology 2020;295 (1):66-79 [PubMed]
  • Reinders F. C. J., Young-Afat D. A., Batenburg M. C. T., Bruekers S. E., van Amerongen E. A., Macaré van Maurik J. F. M., Braakenburg A., Zonnevylle E., Hoefkens M., Teunis T., Verkooijen H. M., van den Bongard H. J. G. D., Maarse W. Higher reconstruction failure and less patient-reported satisfaction after post mastectomy radiotherapy with immediate implant-based breast reconstruction compared to immediate autologous breast reconstruction Breast Cancer 2020;27 (3):435–444 [PubMed]
  • Middelburg J. G., Middelburg R. A., van Zwienen M., Mast M. E., Bhawanie A., Jobsen J. J., Rozema T., Maas H., Geijsen E. D., van der Leest A. H., van den Bongard D. H. J. G., van Loon J., Budiharto T., Aarts M. J., Terhaard C. H. J., Struikmans H. Impaired Geriatric 8 Score is Associated with Worse Survival after Radiotherapy in Older Patients with Cancer Clinical oncology (Royal College of Radiologists (Great Britain)) 2020 [PubMed]
  • Groot Koerkamp Maureen L., Vasmel Jeanine E., Russell Nicola S., Shaitelman Simona F., Anandadas Carmel N., Currey Adam, Vesprini Danny, Keller Brian M., de-Colle Chiara, Han Kathy, Braunstein Lior Z., Mahmood Faisal, Lorenzen Ebbe L., Philippens Marielle E. P., Verkooijen Helena M., Lagendijk Jan J. W., Houweling Antonetta C., van den Bongard H. J. G. Desiree, Kirby Anna M. Optimizing MR-Guided Radiotherapy for Breast Cancer Patients Frontiers in oncology 2020;10 [PubMed]
  • van de Ven Saskia, van den Bongard Desiree, Pielkenrood Bart, Kasperts Nicolien, Eppinga Wietse, Peters Max, Verkooijen Helena, van der Velden Joanne Patient-Reported Outcomes of Oligometastatic Patients After Conventional or Stereotactic Radiation Therapy to Bone Metastases: An Analysis of the PRESENT Cohort International journal of radiation oncology, biology, physics 2020;107 (1):39-47 [PubMed]
  • Raphael D. B., Russell N. S., Immink J. M., Westhoff P. G., Stenfert Kroese M. C., Stam M. R., van Maurik L. M., van den Bongard H. J. G. D., Maduro J. H., Sattler M. G. A., van der Weijden T., Boersma L. J. Risk communication in a patient decision aid for radiotherapy in breast cancer: How to deal with uncertainty? Breast (Edinburgh, Scotland) 2020;51:105-113 [PubMed]
  • Vasmel Jeanine E., Charaghvandi Ramona K., Houweling Antonetta C., Philippens Marielle E. P., van Asselen Bram, Vreuls Celien P. H., van Diest Paul J., van Leeuwen A. M. Gijs, van Gorp Joost, Witkamp Arjen J., Koelemij Ron, Doeksen Annemiek, Sier Maartje F., van Dalen Thijs, van der Wall Elsken, van Dam Iris, Veldhuis Wouter B., Kirby Anna M., Verkooijen Helena M., van den Bongard H. J. G. Desiree Tumor Response After Neoadjuvant Magnetic Resonance Guided Single Ablative Dose Partial Breast Irradiation International journal of radiation oncology, biology, physics 2020;106 (4):821-829 [PubMed]

2019

  • Emaus Marleen J., Išgum Ivana, van Velzen Sanne G. M., van den Bongard H. J. G. Desirée, Gernaat Sofie A. M., Lessmann Nikolas, Sattler Margriet G. A., Teske Arco J., Penninkhof Joan, Meijer Hanneke, Pignol Jean-Philippe, Verkooijen Helena M. Bragatston study protocol: A multicentre cohort study on automated quantification of cardiovascular calcifications on radiotherapy planning CT scans for cardiovascular risk prediction in patients with breast cancer BMJ open 2019;9 (7) [PubMed]
  • Young-Afat Danny A, Gregorowitsch Madelijn L, van den Bongard Desirée H, Burgmans Ine, van der Pol Carmen C, Witkamp Arjen J, Bijlsma Rhodé M, Koelemij Ron, Schoenmaeckers Ernst J, Jonasse Yvette, van Gils Carla H, Verkooijen Helena M Breast Edema Following Breast-Conserving Surgery and Radiotherapy: Patient-Reported Prevalence, Determinants, and Effect on Health-Related Quality of Life JNCI cancer spectrum 2019;3 (2):pkz011 [PubMed]
  • Gregorowitsch Madelijn L., Verkooijen Helena M., Houweling Anette, Fuhler Nick, Koelemij Ron, Schoenmaeckers Ernst J. P., Sier Maartje F., Ernst Miranda F., Witkamp Arjen J., van Dalen Thijs, Young-Afat Danny A., van den Bongard Desiree H. J. G. Impact of modern-day axillary treatment on patient reported arm morbidity and physical functioning in breast cancer patients Radiotherapy and oncology 2019;131:221-228 [PubMed]
  • Batenburg M. C. T., Gregorowitsch M. L., Maarse W., Witkamp A., Young-Afat D. A., Braakenburg A., Doeksen A., van Dalen T., Sier M., Schoenmaeckers E. J. P., van Gils C. H., van den Bongard H. J. G. D., Verkooijen H. M. Patient-reported cosmetic satisfaction and the long-term association with quality of life in irradiated breast cancer patients Breast cancer research and treatment 2019 [PubMed]
  • Gal R., Monninkhof E. M., Peeters P. H. M., van Gils C. H., van den Bongard D. H. J. G., Wendel-Vos G. C. W., Zuithoff N. P. A., Verkooijen H. M., May A. M. Physical activity levels of women with breast cancer during and after treatment, a comparison with the Dutch female population Acta oncologica (Stockholm, Sweden) 2019;58 (5):673-681 [PubMed]
  • Gregorowitsch M. L., van den Bongard H. J. G. D., Couwenberg A. M., Young-Afat D. A., Haaring C., van Dalen T., Schoenmaeckers E. J. P., Agterof M. J., Baas I. O., Sier M. F., Ernst M. F., van Hummel R., Verkooijen H. M. Self-reported work ability in breast cancer survivors; a prospective cohort study in the Netherlands Breast (Edinburgh, Scotland) 2019;48:45-53 [PubMed]
  • Charaghvandi K. R., van't Westeinde T., Yoo S., Houweling A. C., Rodrigues A., Verkooijen H. M., Philippens M. E. P., van Asselen B., Horton J. K., van den Bongard H. J. G. D. Single dose partial breast irradiation using an MRI linear accelerator in the supine and prone treatment position Clinical and Translational Radiation Oncology 2019;14:1-7 [PubMed]
  • Gregorowitsch M. L., Ghedri A., Young-Afat D. A., Bijlsma R., Baas I. O., van Schaik-van de Mheen C., Agterof M. J., Göker E., ten Bokkel Huinink D., van den Bongard H. J. G. D., Verkooijen H. M. The effect of chemotherapy on subjective cognitive function in younger early-stage breast cancer survivors treated with chemotherapy compared to older patients Breast cancer research and treatment 2019;175 (2):429-441 [PubMed]
  • Gal Roxanne, Monninkhof Evelyn M., van Gils Carla H., Groenwold Rolf H. H., van den Bongard Desirée H. J. G., Peeters Petra H. M., Verkooijen Helena M., May Anne M. The Trials within Cohorts design faced methodological advantages and disadvantages in the exercise oncology setting Journal of clinical epidemiology 2019;113:137-146 [PubMed]
  • Buddeke Josefien, Gernaat Sofie A. M., Bots Michiel L., van den Bongard Desirée H. J. G., Grobbee Diederick E., Vaartjes Ilonca, Verkooijen Helena M. Trends in the risk of cardiovascular disease in women with breast cancer in a Dutch nationwide cohort study BMJ open 2019;9 (5) [PubMed]

2018

  • Gernaat Sofie A. M., van Velzen Sanne G. M., Koh Vicky, Emaus Marleen J., Išgum Ivana, Lessmann Nikolas, Moes Shinta, Jacobson Anouk, Tan Poey W., Grobbee Diederick E., van den Bongard Desiree H. J., Tang Johann I., Verkooijen Helena M. Automatic quantification of calcifications in the coronary arteries and thoracic aorta on radiotherapy planning CT scans of Western and Asian breast cancer patients Radiotherapy and oncology 2018;127 (3):487-492 [PubMed]
  • Gregorowitsch M. L., van den Bongard H. J. G. D., Young-Afat D. A., Pignol J. P., van Gils C. H., May A. M., Verkooijen H. M. Severe depression more common in patients with ductal carcinoma in situ than early-stage invasive breast cancer patients Breast cancer research and treatment 2018;167 (1):205-213 [PubMed]
  • Gernaat Sofie A. M., Boer Jolanda M. A., van den Bongard Desiree H. J., Maas Angela H. E. M., van der Pol Carmen C., Bijlsma Rhodé M., Grobbee Diederick E., Verkooijen Helena M., Peeters Petra H. The risk of cardiovascular disease following breast cancer by Framingham risk score Breast cancer research and treatment 2018;170 (1):119-127 [PubMed]

2017

  • Rijkmans Eva C., Cats Annemieke, Nout Remi A., van den Bongard Desiree H. J. G., Ketelaars Martijn, Buijsen Jeroen, Rozema Tom, Franssen Jan-Huib, Velema Laura A., van Triest Baukelien, Marijnen Corrie A. M. Endorectal Brachytherapy Boost After External Beam Radiation Therapy in Elderly or Medically Inoperable Patients With Rectal Cancer: Primary Outcomes of the Phase 1 HERBERT Study International journal of radiation oncology, biology, physics 2017;98 (4):908-917 [PubMed]
  • Knuttel Floortje M., van den Bosch Maurice A. A. J., Young-Afat Danny A., Emaus Marleen J., van den Bongard Desirée H. J. G., Witkamp Arjen J., Verkooijen Helena M. Patient Preferences for Minimally Invasive and Open Locoregional Treatment for Early-Stage Breast Cancer Value in health 2017;20 (3):474-480 [PubMed]
  • Charaghvandi R. K., van Asselen B., Philippens M. E. P., Verkooijen H. M., van Gils C. H., van Diest P. J., Pijnappel R. M., Hobbelink M. G. G., Witkamp A. J., van Dalen T., van der Wall E., van Heijst T. C., Koelemij R., van Vulpen M., van den Bongard H. J. G. D. Redefining radiotherapy for early-stage breast cancer with single dose ablative treatment: A study protocol BMC cancer 2017;17 (1) [PubMed]
  • van Heijst Tristan C. F., Eschbach-Zandbergen Debora, Hoekstra Nienke, van Asselen Bram, Lagendijk Jan J. W., Verkooijen Helena M., Pijnappel Ruud M., de Waard Stephanie N., Witkamp Arjen J., van Dalen Thijs, van den Bongard H. J. G. Desirée, Philippens Marielle E. P. Supine MRI for regional breast radiotherapy: Imaging axillary lymph nodes before and after sentinel-node biopsy Physics in medicine and biology 2017;62 (16):6746-6761 [PubMed]
  • Gal Roxanne, Monninkhof Evelyn M., Groenwold Rolf H. H., van Gils Carla H., van den Bongard Desiree H. J. G., Peeters Petra H. M., Verkooijen Helena M., May Anne M. The effects of exercise on the quality of life of patients with breast cancer (the UMBRELLA Fit study): Study protocol for a randomized controlled trial Trials 2017;18 (1) [PubMed]
  • Young-Afat D. A., van Gils C. H., van den Bongard H. J. G. D., Verkooijen H. M., Gernaat S. A., Gregorowitsch M. L., May A. M., Peeters P. H., van der Pol C. C., Witkamp A. J., Pijnappel R. M., Bijlsma R. M., Maarse W., Ausems M. G., van Diest P. J., van der Wall E., van Dalen T., Burgmans I. P., de Roos M. A., van Doorn R. C., Baas I. O., van Ooijen B., Koelemij R. The Utrecht cohort for Multiple BREast cancer intervention studies and Long-term evaLuAtion (UMBRELLA): objectives, design, and baseline results Breast cancer research and treatment 2017;164 (2):445-450 [PubMed]
  • Middelburg Judith G., Mast Mirjam E., de Kroon Maaike, Jobsen Jan J., Rozema Tom, Maas Huub, Baartman Elizabet A., Geijsen Debby, van der Leest Annija H., van den Bongard Desirée J., van Loon Judith, Budiharto Tom, Coebergh Jan Willem, Aarts Mieke J., Struikmans Henk Timed Get Up and Go Test and Geriatric 8 Scores and the Association With (Chemo-)Radiation Therapy Noncompliance and Acute Toxicity in Elderly Cancer Patients International journal of radiation oncology, biology, physics 2017;98 (4):843-849 [PubMed]
  • Charaghvandi Ramona K., Yoo Sua, van Asselen Bram, Rodrigues Anna, van den Bongard Desirée H. J. G., Horton Janet K. Treatment constraints for single dose external beam preoperative partial breast irradiation in early-stage breast cancer Clinical and Translational Radiation Oncology 2017;6:7-14 [PubMed]

2016

  • de Boer Hans C. J., van den Bongard Desirée J. G., van Asselen Bram Automated daily breath hold stability measurements by real-time imaging in radiotherapy of breast cancer Radiotherapy and oncology 2016;119 (1):61-64 [PubMed]
  • Gernaat Sofie A. M., Išgum Ivana, de Vos Bob D., Takx Richard A. P., Young-Afat Danny A., Rijnberg Noor, Grobbee Diederick E., van der Graaf Yolanda, de Jong Pim A., Leiner Tim, van den Bongard Desiree H. J., Pignol Jean-Philippe, Verkooijen Helena M. Automatic Coronary Artery Calcium Scoring on Radiotherapy Planning CT Scans of Breast Cancer Patients: Reproducibility and Association with Traditional Cardiovascular Risk Factors PLoS ONE 2016;11 (12):e0167925 [PubMed]
  • van Heijst Tristan C. F., van Asselen Bram, Pijnappel Ruud M., Cloos-van Balen Marissa, Lagendijk Jan J. W., van den Bongard Desiŕee, Philippens Marïelle E. P. MRI sequences for the detection of individual lymph nodes in regional breast radiotherapy planning British journal of radiology 2016;89 (1063) [PubMed]
  • Young-Afat Danny A, van Gils Carla H, Bruinvels David J, van der Pol Carmen C, Witkamp Arjen J, Sijtsema Sieta, Jonasse Yvette, Bijlsma Rhodé M, Ausems Margreet G, Bos Annelies M, van den Bongard Desirée H, Verkooijen Helena M Patients' and Health Care Providers' Opinions on a Supportive Health App During Breast Cancer Treatment: A Qualitative Evaluation JMIR cancer 2016;2 (1):e8 [PubMed]
  • van Heijst Tristan C F, Philippens Mariëlle E P, Charaghvandi Ramona K, den Hartogh Mariska D, Lagendijk Jan J W, van den Bongard H J G Desirée, van Asselen Bram Quantification of intra-fraction motion in breast radiotherapy using supine magnetic resonance imaging Physics in medicine and biology 2016;61 (3):1352-70 [PubMed]

2015

  • van der Leij Femke, Bosma Sophie C. J., van de Vijver Marc J., Wesseling Jelle, Vreeswijk Sandra, Rivera Sofia, Bourgier Celine, Garbay Jean-Rémi, Foukakis Theodoros, Lekberg Tobias, van den Bongard Desiree H. J. G. D., van Vliet-Vroegindeweij Corine, Bartelink Harry, Rutgers Emiel J., Elkhuizen Paula H. M. First results of the preoperative accelerated partial breast irradiation (PAPBI) trial Radiotherapy and oncology 2015;114 (3):322-327 [PubMed]
  • Charaghvandi Ramona K., den Hartogh Mariska D., van Ommen Anne-Mar L. N., de Vries Wilfred J. H., Scholten Vincent, Moerland Marinus A., Philippens Mariëlle E. P., Schokker Rogier I., van Vulpen Marco, van Asselen Bram, van den Bongard Desirée H. J. G. MRI-guided single fraction ablative radiotherapy for early-stage breast cancer: A brachytherapy versus volumetric modulated arc therapy dosimetry study Radiotherapy and oncology 2015;117 (3):477-482 [PubMed]
  • van der Heiden-van der Loo M., de Munck L., Sonke G. S., van Dalen T., van Diest P. J., van den Bongard H. J. G. D., Peeters P. H. M., Rutgers E. J. T. Population based study on sentinel node biopsy before or after neoadjuvant chemotherapy in clinically node negative breast cancer patients: Identification rate and influence on axillary treatment European journal of cancer (Oxford, England 2015;51 (8):915-921 [PubMed]
  • den Hartogh Mariska D., Philippens Marielle E. P., van Dam Iris E., Kleynen Catharina E., Tersteeg Robbert J. H. A., Kotte Alexis N. T. J., van Vulpen Marco, van Asselen Bram, van den Bongard Desirée H. J. G. Post-lumpectomy CT-guided tumor bed delineation for breast boost and partial breast irradiation: Can additional pre-and postoperative imaging reduce interobserver variability? Oncology letters 2015;10 (5):2795-2801 [PubMed]

2014

  • den Hartogh Mariska D., van den Bongard H. J. G. Desirée, Davidson Melanie T. M., Kotte Alexis N. T. J., Verkooijen Helena M., Philippens Marielle E. P., van Vulpen Marco, van Asselen Bram, Pignol Jean-Philippe Full-Thickness Closure in Breast-Conserving Surgery: The Impact on Radiotherapy Target Definition for Boost and Partial Breast Irradiation. A Multimodality Image Evaluation Annals of surgical oncology 2014;21 (12):3774-3779 [PubMed]
  • den Hartogh Mariska D., Philippens Marielle E. P., van Dam Iris E., Kleynen Catharina E., Tersteeg Robbert J. H. A., Pijnappel Ruud M., Kotte Alexis N. T. J., Verkooijen Helena M., van den Bosch Maurice A. A. J., van Vulpen Marco, van Asselen Bram, van den Bongard H. J. G. Desirée MRI and CT imaging for preoperative target volume delineation in breast-conserving therapy Radiation oncology (London, England) 2014;9 (1) [PubMed]

2013

  • van Heijst Tristan C. F., den Hartogh Mariska D., Lagendijk Jan J. W., van den Bongard H. J. G. Desirée, van Asselen Bram MR-guided breast radiotherapy: Feasibility and magnetic-field impact on skin dose Physics in medicine and biology 2013;58 (17):5917-5930 [PubMed]
  • Merckel Laura G., Bartels Lambertus W., Köhler Max O., van den Bongard H. J. G. Desirée, Deckers Roel, Mali Willem P. Th. M., Binkert Christoph A., Moonen Chrit T., Gilhuijs Kenneth G. A., van den Bosch Maurice A. A. J. MR-guided high-intensity focused ultrasound ablation of breast cancer with a dedicated breast platform Cardiovascular and interventional radiology 2013;36 (2):292-301 [PubMed]

2012

  • Postma E. L., van Wieringen S., Hobbelink M. G., Verkooijen H. M., van den Bongard H. J. G. D., Borel Rinkes I. H. M., Witkamp A. J. Sentinel lymph node biopsy of the internal mammary chain in breast cancer Breast cancer research and treatment 2012;134 (2):735-741 [PubMed]

2011

  • den Hartogh M. D., van Asselen B., Monninkhof E. M., van den Bosch M. A. A. J., van Vulpen M., van Diest P. J., Gilhuijs K. G. A., Witkamp A. J., van de Bunt L., Mali W. P. T. M., van den Bongard H. J. G. D. Excised and irradiated volumes in relation to the tumor size in breast-conserving therapy Breast cancer research and treatment 2011;129 (3):857-865 [PubMed]

2006

  • Joerger M., Huitema A. D. R., van den Bongard H. J. G. D., Baas P., Schornagel J. H., Schellens J. H. M., Beijnen J. H. Determinants of the elimination of methotrexate and 7-hydroxy-methotrexate following high-dose infusional therapy to cancer patients British journal of clinical pharmacology 2006;62 (1):71-80 [PubMed]
  • Joerger Markus, Huitema Alwin D. R., van den Bongard Desiree H. J. G., Schellens Jan H. M., Beijnen Jos H. Quantitative effect of gender, age, liver function, and body size on the population pharmacokinetics of paclitaxel in patients with solid tumors Clinical cancer research 2006;12 (7 I):2150-2157 [PubMed]

2004

  • Rademaker-Lakhai Jeany M., van den Bongard Desiree, Pluim Dick, Beijnen Jos H., Schellens Jan H. M. A phase I and pharmacological study with imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a novel ruthenium anticancer agent Clinical cancer research 2004;10 (11):3717-3727 [PubMed]
  • de Jonge Milly E., van den Bongard H. J. G. Desirée, Huitema Alwin D. R., Mathôt Ron A. A., Rosing Hilde, Baas Paul, van Zandwijk Nico, Beijnen Jos H., Schellens Jan H. M. Bayesian pharmacokinetically guided dosing of paclitaxel in patients with non-small cell lung cancer Clinical cancer research 2004;10 (7):2237-2244 [PubMed]
  • van den Bongard H. J. G. Desirée, Kemper E. Marleen, van Tellingen Olaf, Rosing Hilde, Mathôt Ron A. A., Schellens Jan H. M., Beijnen Jos H. Development and validation of a method to determine the unbound paclitaxel fraction in human plasma Analytical biochemistry 2004;324 (1):11-15 [PubMed]
  • van den Bongard H. J. G. Desirée, Sparidans Rolf W., Critchley David J. P., Beijnen Jos H., Schellens Jan H. M. Pharmacokinetic drug-drug interaction of the novel anticancer agent E7070 and acenocoumarol Investigational new drugs 2004;22 (2):151-158 [PubMed]

2003

  • van den Bongard H. J. G. D., Pluim D., van Waardenburg R. C. A. M., Ravic M., Beijnen J. H., Schellens J. H. M. In vitro pharmacokinetic study of the novel anticancer agent E7070: Red blood cell and plasma protein binding in human blood Anti-cancer drugs 2003;14 (6):405-410 [PubMed]

2002

  • van den Bongard H. J. G. Desirée, Pluim Dick, Rosing Hilde, Nan-Offeringa Lianda, Schot Margaret, Ravic Miroslav, Schellens Jan H. M., Beijnen Jos H. An excretion balance and pharmacokinetic study of the novel anticancer agent E7070 in cancer patients Anti-cancer drugs 2002;13 (8):807-814 [PubMed]
  • van den Bongard H. J. G. D., Mathôt R. A. A., van Tellingen O., Schellens J. H. M., Beijnen J. H. A population analysis of the pharmacokinetics of Cremophor EL using nonlinear mixed-effect modelling Cancer chemotherapy and pharmacology 2002;50 (1):16-24 [PubMed]
  • van den Bongard H J G Desirée, Boot Henk, Baas Paul, Taal Babs G The role of parallel stent insertion in patients with esophagorespiratory fistulas Gastrointestinal endoscopy 2002;55 (1):110-5 [PubMed]

2001

  • van den Bongard H. J. G. Desirée, Mathôt Ron A. A., Boogerd Willem, Schornagel Jan H., Soesan Marcel, Schellens Jan H. M., Beijnen Jos H. Successful rescue with leucovorin and thymidine in a patient with high-dose methotrexate induced acute renal failure Cancer chemotherapy and pharmacology 2001;47 (6):537-540 [PubMed]
  • Crul M., van den Bongard H. J. G. D., Tibben M. M., van Tellingen O., Sava G., Schellens J. H. M., Beijnen J. H. Validated method for the determination of the novel organo-ruthenium anticancer drug NAMI-A in human biological fluids by Zeeman atomic absorption spectrometry Analytical and bioanalytical chemistry 2001;369 (5):442-445 [PubMed]

2000

  • van den Bongard H. J., Mathôt R. A., Beijnen J. H., Schellens J. H. Pharmacokinetically guided administration of chemotherapeutic agents Clinical pharmacokinetics 2000;39 (5):345-367 [PubMed]
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