- Willuhn Ingo, Burgeno Lauren M., Groblewski Peter A., Phillips Paul E. M. Excessive cocaine use results from decreased phasic dopamine signaling in the striatum Nature neuroscience 2014;17 (5):704-709 [PubMed]
- Willuhn Ingo, Burgeno Lauren M., Everitt Barry J., Phillips Paul E. M. Hierarchical recruitment of phasic dopamine signaling in the striatum during the progression of cocaine use Proceedings of the National Academy of Sciences of the United States of America 2012;109 (50):20703-20708 [PubMed]
- Willuhn Ingo, Tose Amanda, Wanat Matthew J., Hart Andrew S., Hollon Nick G., Phillips Paul E. M., Schwarting Rainer K. W., Wöhr Markus Phasic dopamine release in the nucleus accumbens in response to pro-social 50 kHz ultrasonic vocalizations in rats Journal of neuroscience 2014;34 (32):10616-10623 [PubMed]
- Flagel Shelly B., Clark Jeremy J., Robinson Terry E., Mayo Leah, Czuj Alayna, Willuhn Ingo, Akers Christina A., Clinton Sarah M., Phillips Paul E. M., Akil Huda A selective role for dopamine in stimulus-reward learning Nature 2011;469 (7328):53-57 [PubMed]
- Clark Jeremy J., Sandberg Stefan G., Wanat Matthew J., Gan Jerylin O., Horne Eric A., Hart Andrew S., Akers Christina A., Parker Jones G., Willuhn Ingo, Martinez Vicente, Evans Scott B., Stella Nephi, Phillips Paul E. M. Chronic microsensors for longitudinal, subsecond dopamine detection in behaving animals Nature methods 2010;7 (2):126-129 [PubMed]
EDUCATION
2001-2007 Doctoral dissertation, Department of Cellular and Molecular Pharmacology, Rosalind Franklin University/The Chicago Medical School, Chicago, IL, USA
1996-2001 Diploma in Physiological Psychology (equiv. M.Sc.) at Heinrich-Heine University of Düsseldorf, Germany
RESEARCH EXPERIENCE
2015-present Universitair hoofddocent (UHD), Associate Professor, Academic Medical Center (AMC)
2015-present Group leader, Netherlands Institute for Neuroscience (NIN), Royal Netherlands Academy of Arts and Sciences (KNAW)
2015-present Principal Investigator, Academic Medical Center (AMC)
2014-present Universitair docent (UD), Assistant Professor, Academic Medical Center (AMC)
2014-2015 Senior scientist, Netherlands Institute for Neuroscience (NIN), Royal Netherlands Academy of Arts and Sciences (KNAW)
2010-2013 Scientific advisor of the Behavioral Core Facility for Drug Addiction Research at the University of Washington, Seattle, WA, USA
2008-2013 Postdoctoral research, Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA
2001-2007 Dissertation research, Rosalind Franklin University/The Chicago Medical School, North Chicago, IL, USA
2000-2001 Diploma (MSc) thesis research, Heinrich-Heine University of Düsseldorf, Germany
MSc PhD I. Willuhn (The neurocircuitry of compulsive behavior)
My reserach group studies how the brain produces automatic and habitual actions, and how dysregulation of such actions may contribute to compulsive behavior. Compulsive behavior is believed to be a central common denominator to several neuro-psychiatric disorders such as obsessive-compulsive disorder (OCD), addictions, and eating disorders. Compulsive behavior is likely constituted by the dysregulation of individual behavioral functions (components), such as cognitive inflexibility, and it is aggravated by stress and anxiety, whereby it is hypothesized that aberrant habit formation is crucial for its development. The main objective of my research program is to provide a better understanding of the underlying neurobiological mechanisms of compulsive behavior. In order to do so, compulsive behavior itself and a variety of its presumed components is studied in rodents, while neural measurements and interventions are performed using state-of-the-art methodology. Neural measurements are collected in vivo using electrophysiology, fast-scan cyclic voltammetry, calcium imaging, microdialysis, and fMRI, whereas in vivo interventions include deep-brain stimulation, chemogenetics, optogenetics, and pharmacological treatments. My research is intended to lead to novel insights that may tie psychiatric diseases together that are now often studied and treated separately, and to pave the way to define and treat conditions that are common to OCD, addictions, and eating disorders.
Postdocs
MSc T. Arbab
PhD R. Faust
A. Parthasarathy
P. Warnaar
PhD Students
BA L.M. Burgeno
Others
R.R.T. Hamelink
PhD N. Yee
Prof. PhD D.A.J.P. Denys (Deep Brain Stimulation and Obsessive-Compulsive Disorders)
- AMC (Vrijgesteld)
- Crediteurenadm. VUmc, p/a Profource Service Center
- NWO