J.E. Seppen PhD publications

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Publications PhD J.E. Seppen

Position
Assistant Professor
Main activities
Education
Specialisation
Microbiome, metabolome, metabolism, detoxification, Gene Therapy.
Focus of research

How diet affects intestinal bacterial composition and metabolism and induces remission in Crohn’s disease.

The intestinal microbiome has been implicated in a plethora of human diseases. How the microbiome influences these processes is still largely unknown. We investigate the role of the microbiome and microbial products in inducing remission in Crohn's disease. To this end studies on the compsition of the microbiome and metabolome of patients with Crohn's disease are carried out. From these studies the causal relationship between specific microbes or metabolites and intestinal inflammation should be elucidated.

Therapy with sporulating bacteria

Bacterial spores are resistant to gastric acid, bile salts and pancreatic secretions, they survive passage through the upper gastrointestinal tract and are able to germinate in the intestine after oral administration. Restoring the disturbed microbiome and inducing remission in Crohn's disease by administration of probiotics is considered to be ineffective, likely because probiotics are generally not very well adapted to the human gut or poorly delivered because they cannot survive transit through the upper gastrointestinal tract. We investigate if bacterial spores, either anaerobes that are associated with remission in Crohn's disease or genetically modified sporulating bacteria producing immune modulating compounds, are a potential treatment for Crohns's disease.

 

 

2020

  • Diederen Kay, Li Jia V., Donachie Gillian E., de Meij Tim G., de Waart Dirk R., Hakvoort Theodorus B. M., Kindermann Angelika, Wagner Josef, Auyeung Victoria, te Velde Anje A., Heinsbroek Sigrid E. M., Benninga Marc A., Kinross James, Walker Alan W., de Jonge Wouter J., Seppen Jurgen Exclusive enteral nutrition mediates gut microbial and metabolic changes that are associated with remission in children with Crohn’s disease Scientific reports 2020;10 (1) [PubMed]
  • Botschuijver Sara Gut fungi in irritable bowel syndrome: A painful recognition 2020. 236p. ISBN 9789402818871. [UvA Dissertations Online] University of Amsterdam. (Supervisors: de Jonge Wouter .J,; Co-supervisors: Seppen Jurgen.E., van den Wijngaard Renoldus M. J. G. J.)
  • van Thiel I. A. M., Botschuijver S., de Jonge W. J., Seppen J. Painful interactions: Microbial compounds and visceral pain BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2020;1866 (1) [PubMed]

2019

  • Willemze Rose A., Brinkman David J., Welting Olaf, van Hamersveld Patricia H. P., Verseijden Caroline, Luyer Misha D., Wildenberg Manon E., Seppen Jurgen, de Jonge Wouter J. Acetylcholine-producing T cells augment innate immune-driven colitis but are redundant in T cell-driven colitis American journal of physiology. Gastrointestinal and liver physiology 2019;317 (5):G557-G568 [PubMed]
  • Végh Anna M. D., Dénise den Haan A., Ortega Lucía C. cera, Verkerk Arie O., Sluijter Joost P. G., Bakker Diane, van Amersfoorth Shirley, van Veen Toon A. B., Klerk Mischa, Seppen Jurgen, de Bakker Jacques M. T., Christoffels Vincent M., Geerts Dirk, Goumans Marie José T. H., Tan Hanno L., Boink Gerard J. J. Cardiomyocyte progenitor cells as a functional gene delivery vehicle for long-term biological pacing Molecules 2019;24 (1) [PubMed]
  • Willemze Rose A. Connecting innervation and intestinal inflammation 2019. 191p. ISBN 9789461829443. [UvA Dissertations Online] University of Amsterdam. (Supervisor: de Jonge W. J.; Co-supervisor: Seppen J. E.)
  • Willemze Rose A, Welting Olaf, van Hamersveld Patricia, Verseijden Caroline, Nijhuis Laurens E, Hilbers Francisca W, Meijer Sybren L, Heesters Balthasar A, Folgering Joost H A, Darwinkel Harold, Blancou Philippe, Vervoordeldonk Margriet J, Seppen Jurgen, Heinsbroek Sigrid E M, de Jonge Wouter J Loss of intestinal sympathetic innervation elicits an innate immune driven colitis Molecular medicine (Cambridge, Mass.) 2019;25 (1):1 [PubMed]

2018

  • Willemze R. A., Welting O., van Hamersveld H. P., Meijer S. L., Folgering J. H. A., Darwinkel H., Witherington J., Sridhar A., Vervoordeldonk M. J., Seppen J., de Jonge W. J. Neuronal control of experimental colitis occurs via sympathetic intestinal innervation Neurogastroenterology and motility 2018;30 (3):e13163 [PubMed]
  • Botschuijver S., Welting O., Levin E., Maria-Ferreira D., Koch E., Montijn R. C., Seppen J., Hakvoort T. B. M., Schuren F. H. J., de Jonge W. J., van den Wijngaard R. M. Reversal of visceral hypersensitivity in rat by Menthacarin , a proprietary combination of essential oils from peppermint and caraway, coincides with mycobiome modulation Neurogastroenterology and motility 2018;30 (6):e13299 [PubMed]

2017

  • van Dijk Remco, Aronson Sem J., de Waart Dirk R., van de Graaf Stan F., Duijst Suzanne, Seppen Jurgen, Oude Elferink Ronald, Beuers Ulrich, Bosma Piter J. Biliverdin Reductase inhibitors did not improve severe unconjugated hyperbilirubinemia in vivo Scientific reports 2017;7 (1):1646 [PubMed]
  • Botschuijver Sara, Roeselers Guus, Levin Evgeni, Jonkers Daisy M., Welting Olaf, Heinsbroek Sigrid E. M., de Weerd Heleen H., Boekhout Teun, Fornai Matteo, Masclee Ad A., Schuren Frank H. J., de Jonge Wouter J., Seppen Jurgen, van den Wijngaard René M. Intestinal Fungal Dysbiosis Is Associated With Visceral Hypersensitivity in Patients With Irritable Bowel Syndrome and Rats Gastroenterology 2017;153 (4):1026-1039 [PubMed]

2016

  • Dhawan Shobhit, de Palma Giada, Willemze Rose A., Hilbers Francisca W., Verseijden Caroline, Luyer Misha D., Nuding Sabine, Wehkamp Jan, Souwer Yuri, de Jong Esther C., Seppen J., van den Wijngaard René M., Wehner Sven, Verdu Elena, Bercik Premek, de Jonge Wouter J. Acetylcholine-producing T cells in the intestine regulate antimicrobial peptide expression and microbial diversity American journal of physiology. Gastrointestinal and liver physiology 2016;311 (5):G920-G933 [PubMed]
  • Schilderink Ronald, Verseijden Caroline, Seppen Jurgen, Muncan Vanesa, van den Brink Gijs R., Lambers Tim T., van Tol Eric A., de Jonge Wouter J. The SCFA butyrate stimulates the epithelial production of retinoic acid via inhibition of epithelial HDAC American journal of physiology. Gastrointestinal and liver physiology 2016;310 (11):G1138-G1146 [PubMed]

2015

  • Kingma Sandra D. K., Wagemans Tom, Ijlst Lodewijk, Seppen Jurgen, Gijbels Marion J. J., Wijburg Frits A., van Vlies Naomi Adverse Effects of Genistein in a Mucopolysaccharidosis Type I Mouse Model JIMD reports 2015;23:77-83 [PubMed]

2014

  • van Wenum Martien, Chamuleau Robert Afm, van Gulik Thomas M., Siliakus Adriaan, Seppen Jurgen, Hoekstra Ruurdtje Bioartificial livers in vitro and in vivo: tailoring biocomponents to the expanding variety of applications Expert opinion on biological therapy 2014;14 (12):1745-1760 [PubMed]
  • El Filali Ebtisam, Duijst Suzanne, Hiralall Johan K., Legrand Nicolas, van Gulik Thomas, Hoekstra Ruurdtje, Seppen Jurgen Human fetal liver cells for regulated ex vivo erythropoietin gene therapy Molecular therapy. Methods & clinical development 2014;1:UNSP 14003 [PubMed]
  • El Filali Ebtisam Mice with humanized liver endothelium 2014. 165p. ISBN 9789461824844. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Oude Elferink R. P. J.; Co-supervisor: Seppen J. E.)

2013

  • Filali Ebtisam El, Hiralall Johan K., van Veen Henk A., Stolz Donna B., Seppen Jurgen Human liver endothelial cells, but not macrovascular or microvascular endothelial cells, engraft in the mouse liver Cell transplantation 2013;22 (10):1801-1811 [PubMed]
  • Seppen Jurgen, Bruzzone Linda Lynch syndrome: the patients' perspective Familial cancer 2013;12 (2):341-345 [PubMed]
  • Hoekstra Ruurdtje, Nibourg Geert A. A., van der Hoeven Tessa V., Plomer Gabrielle, Seppen Jurgen, Ackermans Mariëtte T., Camus Sandrine, Kulik Wim, van Gulik Thomas M., Elferink Ronald P. Oude, Chamuleau Robert A. F. M. Phase 1 and phase 2 drug metabolism and bile acid production of HepaRG cells in a bioartificial liver in absence of dimethyl sulfoxide Drug metabolism and disposition: the biological fate of chemicals 2013;41 (3):562-567 [PubMed]
  • Abel Tobias, El Filali Ebtisam, Waern Johan, Schneider Irene C., Yuan Qinggong, Münch Robert C., Hick Meike, Warnecke Gregor, Madrahimov Nodir, Kontermann Roland E., Schüttrumpf Jörg, Müller Ulrike C., Seppen Jurgen, Ott Michael, Buchholz Christian J. Specific gene delivery to liver sinusoidal and artery endothelial cells Blood 2013;122 (12):2030-2038 [PubMed]

2012

  • Seppen Jurgen A diet containing the soy phytoestrogen genistein causes infertility in female rats partially deficient in UDP glucuronyltransferase Toxicology and applied pharmacology 2012;264 (3):335-342 [PubMed]
  • Seppen Jurgen, Bosma Piter Bilirubin, the Gold Within Circulation 2012;126 (22):2547-2549 [PubMed]
  • Folmer Dineke E., Mok Kam S., de Wee Sebastiaan W., Duijst Suzanne, Hiralall Johan K., Seppen Jurgen, Oude Elferink Ronald P. J., Paulusma Coen C. Cellular Localization and Biochemical Analysis of Mammalian CDC50A, a Glycosylated beta-subunit for P4 ATPases journal of histochemistry and cytochemistry 2012;60 (3):205-218 [PubMed]
  • Falix Farah A., Aronson Daniel C., Lamers Wouter H., Hiralall Johan K., Seppen Jurgen DLK1, a serum marker for hepatoblastoma in young infants Pediatric blood & cancer 2012;59 (4):743-745 [PubMed]
  • Bakker Martijn L., Boink Gerard J. J., Boukens Bas J., Verkerk Arie O., van den Boogaard Malou, Den Haan A. Denise, Hoogaars Willem M. H., Buermans Henk P., de Bakker Jacques M. T., Seppen Jurgen, Tan Hanno L., Moorman Antoon F. M., 't Hoen Peter A. C., Christoffels Vincent M. T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells Cardiovascular research 2012;94 (3):439-449 [PubMed]

2011

  • Groen Annemiek, Romero Marta Rodriguez, Kunne Cindy, Hoosdally Sarah J., Dixon Peter H., Wooding Carol, Williamson Catherine, Seppen Jurgen, van den Oever Karin, Mok Kam S., Paulusma Coen C., Linton Kenneth J., Oude Elferink Ronald P. J. Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity Gastroenterology 2011;141 (5):1927-37.e1-4 [PubMed]

2010

  • Centlivre M., Zhou X., Pouw S. M., Weijer K., Kleibeuker W., Das A. T., Blom B., Seppen J., Berkhout B., Legrand N. Autoregulatory lentiviral vectors allow multiple cycles of doxycycline-inducible gene expression in human hematopoietic cells in vivo Gene therapy 2010;17 (1):14-25 [PubMed]
  • Markusic David, Seppen Jurgen Doxycycline regulated lentiviral vectors Methods in molecular biology (Clifton, N.J.) 2010;614:69-76 [PubMed]
  • Van Hooft Jeanin, Elferink Ronald Oude, Seppen Jurgen Gulzigheid en boete: Laxatiekuren en 'leverstenen' Nederlands tijdschrift voor geneeskunde 2010;154 (51-52):2391-2393
  • van Hooft J., Oude Elferink R., Seppen J. Gulzigheid en Boete Nederlands tijdschrift voor geneeskunde 2010;154 (51-52):A2645 [PubMed]
  • Markusic David M., de Waart Dirk R., Seppen Jurgen Separating lentiviral vector injection and induction of gene expression in time, does not prevent an immune response to rtTA in rats PLoS ONE 2010;5 (4):e9974 [PubMed]
  • May Tobias, Butueva Milada, Bantner Sara, Markusic David, Seppen Jurgen, MacLeod Roderick A. F., Weich Herbert, Hauser Hansjörg, Wirth Dagmar Synthetic gene regulation circuits for control of cell expansion Tissue engineering. Part A 2010;16 (2):441-452 [PubMed]

2009

  • Deurholt Tanja, van Til Niek P., Chhatta Aniska A., ten Bloemendaal Lysbeth, Schwartlander Ruth, Payne Catherine, Plevris John N., Sauer Igor M., Chamuleau Robert A. F. M., Oude Elferink Ronald P. J., Seppen Jurgen, Hoekstra Ruurdtje Novel immortalized human fetal liver cell line, cBAL111, has the potential to differentiate into functional hepatocytes BMC biotechnology 2009;9 (1):89 [PubMed]
  • Markusic David M., van Til Niek P., Hiralall Johan K., Elferink Ronald P. J. Oude, Seppen Jurgen Reduction of liver macrophage transduction by pseudotyping lentiviral vectors with a fusion envelope from Autographa californica GP64 and Sendai virus F2 domain BMC biotechnology 2009;9 (1):85 [PubMed]
  • Seppen Jurgen, El Filali Ebtisam, Oude Elferink Ronald Small animal models of hepatocyte transplantation Methods in molecular biology (Clifton, N.J.) 2009;481:1-8 [PubMed]

2008

  • van Til Niek P., Heutinck Kirstin M., van der Rijt Roos, Paulusma Coen C., van Wijland Michel, Markusic David M., Elferink Ronald P. J. Oude, Seppen Jurgen Alteration of viral lipid composition by expression of the phospholipid floppase ABCB4 reduces HIV vector infectivity Retrovirology 2008;5:14 [PubMed]
  • Boink Gerard J. J., Verkerk Arie O., van Amersfoorth Shirley C. M., Tasseron Sara J., van der Rijt Roos, Bakker Diane, Linnenbank André C., van der Meulen Jan, de Bakker Jacques M. T., Seppen Jurgen, Tan Hanno L. Engineering physiologically controlled pacemaker cells with lentiviral HCN4 gene transfer journal of gene medicine 2008;10 (5):487-497 [PubMed]

2007

  • Boink G. J. J., Seppen J., de Bakker J. M. T., Tan H. L. Biological pacing by gene and cell therapy Netherlands heart journal 2007;15 (9):318-322 [PubMed]
  • Gierman Hinco J., Indemans Mireille H. G., Koster Jan, Goetze Sandra, Seppen Jurgen, Geerts Dirk, van Driel Roel, Versteeg Rogier Domain-wide regulation of gene expression in the human genome Genome research 2007;17 (9):1286-1295 [PubMed]
  • Boink Gerard J. J., Seppen Jurgen, de Bakker Jacques M. T., Tan Hanno L. Gene therapy to create biological pacemakersin: J. A. E. Spaan, R. Coronel, J. M. T. de Bakker, Antonio Zaza, editors. Biopacemaking. Berlin-Heidelberg: Springer Verlag; 2007. p. 79-93
  • Boink Gerard J. J., Seppen Jurgen, de Bakker Jacques M. T., Tan Hanno L. Gene therapy to create biological pacemakers Medical & biological engineering & computing 2007;45 (2):167-176 [PubMed]
  • van Til N. P. Lentiviral gene therapy for the treatment of inherited liver disease 2007. 132p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Oude Elferink Ronald P. J.; Co-supervisor: Seppen Jurgen)
  • Markusic David M. Lentiviral vectors for regulated and liver directed gene therapy 2007. 117p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Oude Elferink Ronald P. J.; Co-supervisor: Seppen Jurgen)
  • Markusic David M., Kanitz Alexander, Oude-Elferink Ronald P. J., Seppen Jurgen Preferential gene transfer of lentiviral vectors to liver-derived cells, using a hepatitis B peptide displayed on GP64 Human gene therapy 2007;18 (7):673-679 [PubMed]
  • Vrins Carlos, Vink Edwin, Vandenberghe Kristin E., Frijters Raoul, Seppen Jurgen, Groen Albert K. The sterol transporting heterodimer ABCG5/ABCG8 requires bile salts to mediate cholesterol efflux FEBS letters 2007;581 (24):4616-4620 [PubMed]

2006

  • Seppen Jurgen, Bakker Conny, de Jong Berry, Kunne Cindy, van den Oever Karin, Vandenberghe Kristin, de Waart Rudi, Twisk Jaap, Bosma Piter Adeno-associated virus vector serotypes mediate sustained correction of bilirubin UDP glucuronosyltransferase deficiency in rats Molecular therapy 2006;13 (6):1085-1092 [PubMed]
  • Seppen J., van Til N. P., van der Rijt R., Hiralall J. K., Kunne C., Oude Elferink R. P. J. Immune response to lentiviral bilirubin UDP-glucuronosyltransferase gene transfer in fetal and neonatal rats Gene therapy 2006;13 (8):672-677 [PubMed]
  • Deurholt Tanja, ten Bloemendaal Lysbeth, Chhatta Aniska A., van Wijk Albert C. W. A., Weijer Kees, Seppen Jurgen, Elferink Ronald P. J. Oude, Chamuleau Robert A. F. M., Hoekstra Ruurdtje In vitro functionality of human fetal liver cells and clonal derivatives under proliferative conditions Cell transplantation 2006;15 (8-9):811-822 [PubMed]
  • Bonta Peter I., van Tiel Claudia M., Vos Mariska, Pols Thijs W. H., van Thienen Johannes V., Ferreira Valérie, Arkenbout E. Karin, Seppen Jurgen, Spek C. Arnold, van der Poll Tom, Pannekoek Hans, de Vries Carlie J. M. Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses Arteriosclerosis, thrombosis, and vascular biology 2006;26 (10):2288-2294 [PubMed]

2005

  • Markusic David, Oude-Elferink Ronald, Das Atze T., Berkhout Ben, Seppen Jurgen Comparison of single regulated lentiviral vectors with rtTA expression driven by an autoregulatory loop or a constitutive promoter Nucleic acids research 2005;33 (6):e63 [PubMed]
  • Dekker Rob J., van Thienen Johannes V., Rohlena Jakub, de Jager Saskia C., Elderkamp Yvonne W., Seppen Jurgen, de Vries Carlie J. M., Biessen Erik A. L., van Berkel Theo J. C., Pannekoek Hans, Horrevoets Anton J. G. Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genes American journal of pathology 2005;167 (2):609-618 [PubMed]
  • van Til Niek P., Markusic David M., van der Rijt Roos, Kunne Cindy, Hiralall Johan K., Vreeling Heleen, Frederiks Wilma M., Oude-Elferink Ronald P. J., Seppen Jurgen Kupffer cells and not liver sinusoidal endothelial cells prevent lentiviral transduction of hepatocytes Molecular therapy 2005;11 (1):26-34 [PubMed]
  • Bot Ilze, Guo Jian, van Eck Miranda, van Santbrink Peter J., Groot Pieter H. E., Hildebrand Reeni B., Seppen Jurgen, van Berkel Theo J. C., Biessen Erik A. L. Lentiviral shRNA silencing of murine bone marrow cell CCR2 leads to persistent knockdown of CCR2 function in vivo Blood 2005;106 (4):1147-1153 [PubMed]
  • Barry Simon, Brzezinski Margaret, Yanay Ofer, Seppen Jurgen E., Osborne William R. A. Sustained elevation of neutrophils in rats induced by lentivirus-mediated G-CSF delivery journal of gene medicine 2005;7 (12):1510-1516 [PubMed]

2004

  • Carlotti Françoise, Bazuine Merlijn, Kekarainen Tuija, Seppen Jurgen, Pognonec Philippe, Maassen J. Antonie, Hoeben Rob C. Lentiviral vectors efficiently transduce quiescent mature 3T3-L1 adipocytes Molecular therapy 2004;9 (2):209-217 [PubMed]
  • Seppen Jurgen Unedited inhibition of HBV replication by APOBEC3G Journal of hepatology 2004;41 (6):1068-1069 [PubMed]

2003

  • Seppen Jurgen, van der Rijt Roos, Looije Norbert, van Til Niek P., Lamers Wouter H., Oude Elferink Ronald P. J. Long-term correction of bilirubin UDPglucuronyltransferase deficiency in rats by in utero lentiviral gene transfer Molecular therapy 2003;8 (4):593-599 [PubMed]

2002

  • Weijer Kees, Uittenbogaart Christel H., Voordouw Arie, Couwenberg Franka, Seppen Jurgen, Blom Bianca, Vyth-Dreese Florry A., Spits Hergen Intrathymic and extrathymic development of human plasmacytoid dendritic cell precursors in vivo Blood 2002;99 (8):2752-2759 [PubMed]
  • Seppen Jurgen, Rijnberg Martijn, Cooreman Michel P., Oude Elferink Ronald P. J. Lentiviral vectors for efficient transduction of isolated primary quiescent hepatocytes Journal of hepatology 2002;36 (4):459-465 [PubMed]

2001

  • Seppen J., Barry S. C., Harder B., Osborne W. R. Lentivirus administration to rat muscle provides efficient sustained expression of erythropoietin Blood 2001;98 (3):594-596 [PubMed]
  • Barry S. C., Harder B., Brzezinski M., Flint L. Y., Seppen J., Osborne W. R. Lentivirus vectors encoding both central polypurine tract and posttranscriptional regulatory element provide enhanced transduction and transgene expression Human gene therapy 2001;12 (9):1103-1108 [PubMed]

2000

  • Seppen J., Barry S. C., Klinkspoor J. H., Katen L. J., Lee S. P., Garcia J. V., Osborne W. R. Apical gene transfer into quiescent human and canine polarized intestinal epithelial cells by lentivirus vectors Journal of virology 2000;74 (16):7642-7645 [PubMed]
  • Barry S. C., Seppen J., Ramesh N., Foster J. L., Seyama K., Ochs H. D., Garcia J. V., Osborne W. R. Lentiviral and murine retroviral transduction of T cells for expression of human CD40 ligand Human gene therapy 2000;11 (2):323-332 [PubMed]
  • Seppen J., Barry S., Lam G. M., Ramesh N., Osborne W. R. Retroviral preparations derived from PA317 packaging cells contain inhibitors that copurify with viral particles and are devoid of viral vector RNA Human gene therapy 2000;11 (5):771-775 [PubMed]

1999

  • Wei M. Q., Lejnieks D. V., Ramesh N., Lau S., Seppen J., Osborne W. R. Sustained gene expression in transplanted skin fibroblasts in rats Gene therapy 1999;6 (5):840-844 [PubMed]

1997

  • Seppen J., Kimmel R. J., Osborne W. R. Serum-free production, concentration and purification of recombinant retroviruses BioTechniques 1997;23 (5):788-790 [PubMed]
  • Seppen J., Tada K., Ottenhoff R., Sengupta K., Chowdhury N. R., Chowdhury J. R., Bosma P. J., Oude Elferink R. P. Transplantation of Gunn rats with autologous fibroblasts expressing bilirubin UDP-glucuronosyltransferase: correction of genetic deficiency and tumor formation Human gene therapy 1997;8 (1):27-36 [PubMed]

1996

  • Seppen J., Steenken E., Lindhout D., Bosma P. J., Elferink R. P. A mutation which disrupts the hydrophobic core of the signal peptide of bilirubin UDP-glucuronosyltransferase, an endoplasmic reticulum membrane protein, causes Crigler-Najjar type II FEBS letters 1996;390 (3):294-298 [PubMed]
  • Seppen J., Tada K., Hellwig S., Bakker C. T., Prasad V. R., Roy Chowdhury N., Roy Chowdhury J., Bosma P. J., Oude Elferink R. P. Bilirubin glucuronidation by intact Gunn rat fibroblasts expressing bilirubin UDP-glucuronosyltransferase Biochemical journal 1996;314 ( Pt 2):477-483 [PubMed]

1995

  • Seppen J., Jansen P. L., Oude Elferink R. P. Immunoaffinity purification and reconstitution of the human bilirubin/phenol UDP-glucuronosyltransferase family Protein expression and purification 1995;6 (2):149-154 [PubMed]

1994

  • Bosma P. J., Seppen J., Goldhoorn B., Bakker C., Oude Elferink R. P., Chowdhury J. R., Chowdhury N. R., Jansen P. L. Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man Journal of biological chemistry 1994;269 (27):17960-17964 [PubMed]
  • Seppen J., Bosma P. J., Goldhoorn B. G., Bakker C. T., Chowdhury J. R., Chowdhury N. R., Jansen P. L., Oude Elferink R. P. Discrimination between Crigler-Najjar type I and II by expression of mutant bilirubin uridine diphosphate-glucuronosyltransferase Journal of clinical investigation 1994;94 (6):2385-2391 [PubMed]
  • Bosma P. J., Seppen J., Goldhoorn B., Bakker C., Elferink R. P.J.O., Chowdhury J. R., Chowdhury N. R., Jansen P. L.M. Erratum: Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man (Journal of Biological Chemistry (1994) 269 (17960-17964)) Journal of biological chemistry 1994;269 (41):25942

1992

  • Seppen J., Ramalho-Santos J., de Carvalho A. P., ter Beest M., Kok J. W., de Lima M. C., Hoekstra D. Interaction of clathrin with large unilamellar phospholipid vesicles at neutral pH. Lipid dependence and protein penetration BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1992;1106 (1):209-215 [PubMed]