Publications MD MSc K. Bolhuis
- Position
- PhD Candidate
- Main activities
- Research
- Specialisation
- colorectal cancer and liver metastases
- Focus of research
Approximately 50% of patients with colorectal cancer (CRC) will develop metastases, and 25% will present with distant metastases at diagnosis. CRC disseminates predominantly to the liver.
In patients with coloreactal cancer en liver-only metastases the 5 year overall survival rates has clearly improved due to increased use of surgical resections of metastases, development of new surgical methods and interventions and efficacy of systemic drugs. In patients with initial unresectable metastases can become secondary resectable after downsizing metastases with induction systemic therapy. However, the optimal neoadjuvant induction regimen has not been defined, and no consensus exist on criteria for resectability. CAIRO5 is a phase 3 randomised clinical trial of the Dutch Colorectal Cancer Group comparing induction treatment strategies in colorectal cancer patients in initially unresectable liver-only metastases. In this multi-center study the planned patient accrual is 564 and the primary endpoint is median progression-free survival.
In the next 3 years the PhD candidate will focus on analyzing data of patients with liver –only metastases in colorectal cancer.
2020
- Bolhuis Karen, Kos Milan, van Oijen Martijn G. H., Swijnenburg Rutger-Jan, Punt Cornelis J. A. Conversion strategies with chemotherapy plus targeted agents for colorectal cancer liver-only metastases: A systematic review European journal of cancer (Oxford, England 2020;141:225-238 [PubMed]
- van 't Erve Iris, Greuter Marjolein J. E., Bolhuis Karen, Vessies Daan C. L., Leal Alessandro, Vink Geraldine R., van den Broek Daan, Velculescu Victor E., Punt Cornelis J. A., Meijer Gerrit A., Coupé Veerle M. H., Fijneman Remond J. A. Diagnostic Strategies toward Clinical Implementation of Liquid Biopsy RAS/BRAF Circulating Tumor DNA Analyses in Patients with Metastatic Colorectal Cancer Journal of molecular diagnostics 2020;22 (12):1430-1437 [PubMed]
- Bolhuis K., Tiemeier H. Disruptieve gedragsproblemen op de kinderleeftijd: Studies naar fenotypische heterogeniteit en neurobiologie in de Generation R Studie Tijdschrift voor psychiatrie 2020;62 (12):1049-1058
2019
- Huiskens Joost, Bolhuis Karen, Engelbrecht Marc R. W., de Jong Koert P., Kazemier Geert, Liem Mike S. L., Verhoef Cornelis, de Wilt Johannes H. W., Punt Cornelis J. A., van Gulik Thomas M., van Amerongen M. J., Dejong Cornelis H. C., Gerhards Michael F., Grunhagen Dirk, Heijmen Linda, Hermans John J., Keijser Astrid, Klaase Joost M., van Lienden Krijn P., Molenaar Quintus I., Patijn Gijs A., Rijken Arjen M., Ruers Theo M., Swijnenburg Rutger-Jan, van Tinteren Harm Outcomes of Resectability Assessment of the Dutch Colorectal Cancer Group Liver Metastases Expert Panel Journal of the American College of Surgeons 2019;229 (6):523-532.e2 [PubMed]
2018
- Bolhuis K., Bakker L. J., Keijer J. T., de Vries P. J. Correction to: Implementing a hospital-wide protocol for Staphylococcus aureus bacteremia (European Journal of Clinical Microbiology & Infectious Diseases, (2018), 37, 8, (1553-1562), 10.1007/s10096-018-3284-9) European journal of clinical microbiology & infectious diseases 2018;37 (11):2223 [PubMed]
- Bolhuis K., Bakker L. J., Keijer J. T., de Vries P. J. Implementing a hospital-wide protocol for Staphylococcus aureus bacteremia European journal of clinical microbiology & infectious diseases 2018;37 (8):1553-1562 [PubMed]