K.C. Wolthers MD PhD publications

foto

Publications MD PhD K.C. Wolthers

Position
Medical Specialist
Main activities
Patient care, Research
Specialisation
Medical Microbiology/virology
Focus of research

Molecular epidemiology and pathogenesis of human parechoviruses and enteroviruses

2021

  • Smit Colette, Boyd Anders, Rijnders Bart J. A., van de Laar Thijs J. W., Leyten Eliane M., Bierman Wouter F., Newsum Astrid M., Schinkel Janke, Prins Maria, van der Valk Marc, Reiss Peter, van der Valk M., Geerlings S. E., Goorhuis A., Hovius J. W., Nellen F. J. B., van der Poll T., Prins J. M., van Vugt M., Wiersinga W. J., Wit F. W. M. N., Jurriaans S., Back N. K. T., Zaaijer H. L., Berkhout B., Cornelissen M. T. E., Schinkel C. J., Wolthers K. C., Sigaloff K. C. E., Ang C. W., Reuwer A., Nellen J., van Nood E., Renckens R., Kok M., Hoogerwerf J., Richel O., Stelma F. F., Langebeek N., Lauw F. N., van Wijk M., Bakker M., Stienstra Y., Reiss P., Bezemer D. O., van Sighem A. I., Smit C., van de Sande L., Groters M., Schoorl M. HCV micro-elimination in individuals with HIV in the Netherlands 4 years after universal access to direct-acting antivirals: a retrospective cohort study Lancet HIV 2021;8 (2):e96-e105 [PubMed]

2020

  • Roodsant Thomas, Navis Marit, Aknouch Ikrame, Renes Ingrid B., van Elburg Ruurd M., Pajkrt Dasja, Wolthers Katja C., Schultsz Constance, van der Ark Kees C. H., Sridhar Adithya, Muncan Vanesa A Human 2D Primary Organoid-Derived Epithelial Monolayer Model to Study Host-Pathogen Interaction in the Small Intestine Frontiers in cellular and infection microbiology 2020;10 [PubMed]
  • Sridhar Adithya, Simmini Salvatore, Ribeiro Carla M. S., Tapparel Caroline, Evers Melvin M., Pajkrt Dasja, Wolthers Katja A Perspective on Organoids for Virology Research Viruses 2020;12 (11) [PubMed]
  • Depla Josse A., Sogorb-Gonzalez Marina, Mulder Lance A., Heine Vivi M., Konstantinova Pavlina, van Deventer Sander J., Wolthers Katja C., Pajkrt Dasja, Sridhar Adithya, Evers Melvin M. Cerebral Organoids: A Human Model for AAV Capsid Selection and Therapeutic Transgene Efficacy in the Brain Molecular therapy. Methods & clinical development 2020;18:167-175 [PubMed]
  • Simmonds P., Gorbalenya A. E., Harvala H., Hovi T., Knowles N. J., Lindberg A. M., Oberste M. S., Palmenberg A. C., Reuter G., Skern T., Tapparel C., Wolthers K. C., Woo P. C. Y., Zell R. Correction to: Recommendations for the nomenclature of enteroviruses and rhinoviruses (Archives of Virology, (2020), 165, 3, (793-797), 10.1007/s00705-019-04520-6) Archives of virology 2020;165 (6):1515 [PubMed]
  • van Zeggeren I. E., Edridge A. W. D., van de Beek D., Deijs M., Koekkoek S. M., Wolthers K. C., van der Hoek L., Brouwer M. C. Diagnostic accuracy of VIDISCA-NGS in patients with suspected central nervous system infections Clinical microbiology and infection 2020 [PubMed]
  • Parker Edyth, Han Alvin, Brouwer Lieke, Wolthers Katja, Benschop Kimberley, Russell Colin A. Genotypic diversity and dynamic nomenclature of Parechovirus A bioRxiv 2020
  • Brouwer Lieke, Wolthers Katja C., Pajkrt Dasja Parechovirus A prevalence in adults in The Netherlands Archives of virology 2020;165 (4):963-966 [PubMed]
  • García-Rodríguez Inés, Sridhar Adithya, Pajkrt Dasja, Wolthers Katja C. Put Some Guts into It: Intestinal Organoid Models to Study Viral Infection Viruses 2020;12 (11) [PubMed]
  • Benschop Kimberley S. M., Nguyen Dung, Kamau Everlyn, Pajkrt Dasja, Simmonds Peter, Wolthers Katja C. Recombination analysis of non-poliovirus members of the enterovirus c species; restriction of recombination events to members of the same 3DPOL cluster Viruses 2020;12 (7) [PubMed]
  • Simmonds P., Gorbalenya A. E., Harvala H., Hovi T., Knowles N. J., Lindberg A. M., Oberste M. S., Palmenberg A. C., Reuter G., Skern T., Tapparel C., Wolthers K. C., Woo P. C. Y., Zell R. Recommendations for the nomenclature of enteroviruses and rhinoviruses Archives of virology 2020;165 (3):793-797 [PubMed]
  • Brouwer Lieke The peculiar story of the ubiquitous Enterovirus and its enigmatic companion, the Parechovirus 2020. 234p. ISBN 9789464210033. [UvA Dissertations Online] University of Amsterdam. (Supervisor: de Jong Menno D.; Co-supervisors: Wolthers Katja C., Pajkrt Dasja)

2019

  • de Blauw Dirkje, Bruning Ahl, Vijn L. J., Wildenbeest J. G., Wolthers K. C., Biezeveld M. H., van Wermeskerken Anne-Marie, Nauta Femke, Pajkrt Dasja Blood and cerebrospinal fluid characteristics in neonates with a suspected central nervous system infection Medicine 2019;98 (25):e16079 [PubMed]
  • Karelehto Eveliina, Koen Gerrit, Benschop Kimberley, van der Klis Fiona, Pajkrt Dasja, Wolthers Katja Enterovirus D68 serosurvey: evidence for endemic circulation in the Netherlands, 2006 to 2016 Euro surveillance 2019;24 (35) [PubMed]
  • Brouwer Lieke, Karelehto Eveliina, Han Alvin X., Thomas Xiomara V., Bruning Andrea H. L., Calis Job C. J., van Hensbroek Michaël Boele, Westerhuis Brenda M., Amarthalingam Darsha, Koekkoek Sylvie M., Rebers Sjoerd P. H., Phiri Kamija S., Wolthers Katja C., Pajkrt Dasja High frequency and diversity of parechovirus A in a cohort of Malawian children Archives of virology 2019;164 (3):799-806 [PubMed]
  • Cremer Jeroen, Morley Ursula, Pas Suzan, Wolthers Katja, Vennema Harry, Duizer Erwin, Benschop Kimberley Highly sensitive parechovirus CODEHOP PCR amplification of the complete VP1 gene for typing directly from clinical specimens and correct typing based on phylogenetic clustering Journal of medical microbiology 2019;68 (8):1194-1203 [PubMed]
  • Sridhar Adithya, Karelehto Eveliina, Brouwer Lieke, Pajkrt Dasja, Wolthers Katja C. Parechovirus A Pathogenesis and the Enigma of Genotype A-3 Viruses 2019;11 (11) [PubMed]
  • Karelehto Eveliina, Brouwer Lieke, Benschop Kimberley, Kok Jen, Basile Kerri, McMullan Brendan, Rawlinson William, Druce Julian, Nicholson Suellen, Selvarangan Rangaraj, Harrison Christopher, Lankachandra Kamani, van Eijk Hetty, Koen Gerrit, de Jong Menno, Pajkrt Dasja, Wolthers Katja C. Seroepidemiology of parechovirus A3 neutralizing antibodies, Australia, The Netherlands, and United States Emerging infectious diseases 2019;25 (1):148-152 [PubMed]

2018

  • Elders Philip N. D., In 't Veld Josine, Termote Jacqueline, de Vries Linda S., Hemels Marieke A. C., van Straaten Henrica L. M., van der Sluijs Jacqueline, Kornelisse René F., Wolthers Katja C., van de Loo Moniek, Pajkrt Dasja Congenital Cytomegalovirus Infection and the Occurrence of Cystic Periventricular Leukomalacia Pediatric neurology 2018;79:59-60 [PubMed]
  • van der Sanden Sabine M. G., Sachs Norman, Koekkoek Sylvie M., Koen Gerrit, Pajkrt Dasja, Clevers Hans, Wolthers Katja C. Enterovirus 71 infection of human airway organoids reveals VP1-145 as a viral infectivity determinant article Emerging microbes and infections 2018;7 (1) [PubMed]
  • de Jong Eveline P., van den Beuken Monique G. A., van Elzakker Erika P. M., Wolthers Katja C., Sprij Arwen J., Lopriore Enrico, Walther Frans J., Brus Frank Epidemiology of Sepsis-like Illness in Young Infants Major Role of Enterovirus and Human Parechovirus Pediatric infectious disease journal 2018;37 (2):113-118 [PubMed]
  • Brouwer Lieke, van der Sanden Sabine M. G., Calis Job C. J., Bruning Andrea H. L., Wang Steven, Wildenbeest Joanne G., Rebers Sjoerd P. H., Phiri Kamija S., Westerhuis Brenda M., van Hensbroek Michaël Boele, Pajkrt Dasja, Wolthers Katja C. High frequency of Polio-like Enterovirus C strains with differential clustering of CVA-13 and EV-C99 subgenotypes in a cohort of Malawian children Archives of virology 2018;163 (10):2645-2653 [PubMed]
  • Karelehto Eveliina, Wildenbeest Joanne G., Benschop Kimberley S. M., Koen Gerrit, Rebers Sjoerd, Bouma-de Jongh Saskia, Westerhuis Brenda M., de Jong Menno D., Pajkrt Dasja, Wolthers Katja C. Human Parechovirus 1, 3 and 4 Neutralizing Antibodies in Dutch Mothers and Infants and Their Role in Protection Against Disease Pediatric infectious disease journal 2018;37 (12):1304-1308 [PubMed]
  • Berk Mylene C, Bruning Andrea H L, van Wassenaer-Leemhuis Aleid G, Wolthers Katja C, Pajkrt Dasja Human Parechovirus Meningitis with Adverse Neurodevelopmental Outcome: A Case Report Pediatric infectious disease journal 2018;37 (10):e256-e257 [PubMed]
  • Karelehto Eveliina On parechovirus prevalence and pathogenesis 2018. ISBN 9789463751261. [UvA Dissertations Online] University of Amsterdam. (Supervisor: de Jong M. D.; Co-supervisor: Wolthers K. C.)
  • Karelehto Eveliina, Cristella Cosimo, Yu Xiao, Sridhar Adithya, Hulsdouw Rens, de Haan Karen, van Eijk Hetty, Koekkoek Sylvie, Pajkrt Dasja, de Jong Menno D., Wolthers Katja C. Polarized entry of human parechoviruses in the airway epithelium Frontiers in cellular and infection microbiology 2018;8 (AUG) [PubMed]
  • Bruning A. H. L., Aatola H., Toivola H., Ikonen N., Savolainen-Kopra C., Blomqvist S., Pajkrt D., Wolthers K. C., Koskinen J. O. Rapid detection and monitoring of human coronavirus infections New microbes and new infections 2018;24:52-55 [PubMed]
  • Harvala Heli, Broberg Eeva, Benschop Kimberley, Berginc Natasa, Ladhani Shamez, Susi Petri, Christiansen Claus, McKenna James, Allen David, Makiello Phoebe, McAllister Georgina, Carmen Mirabelli, Zakikhany Katherina, Dyrdak Robert, Nielsen Xiaohui, Madsen Tina, Paul Joel, Moore Catherine, von Eije Karin, Piralla Antonio, Carlier Mieke, Vanoverschelde Laura, Poelman Randy, Anton Andrés, López-Labrador F. Xavier, Pellegrinelli Laura, Keeren Kathrin, Maier Melanie, Cassidy Hayley, Derdas Stavros, Savolainen-Kopra Carita, Diedrich Sabine, Nordbø Svein, Buesa Javier, Bailly Jean-Luc, Baldanti Fausto, MacAdam Andrew, Mirand Audrey, Dudman Susanne, Schuffenecker Isabelle, Kadambari Seilesh, Neyts Johan, Griffiths Michael J., Richter Jan, Margaretto Cristina, Govind Sheila, Morley Ursula, Adams Ortwin, Krokstad Sidsel, Dean Jonathan, Pons-Salort Margarita, Prochazka Birgit, Cabrerizo Maria, Majumdar Manasi, Nebbia Gaia, Wiewel Maryse, Cottrell Simon, Coyle Peter, Martin Javier, Moore Catrin, Midgley Sofie, Horby Peter, Wolthers Katja, Simmonds Peter, Niesters Hubert, Fischer Thea K. Recommendations for enterovirus diagnostics and characterisation within and beyond Europe Journal of clinical virology 2018;101:11-17 [PubMed]
  • Bruning Andrea H. L., de Kruijf Wilhelmina B., van Weert Henk C. P. M., Vrakking Anja, de Jong Menno D., Wolthers Katja C., Pajkrt Dasja Respiratory Viruses in a Primary Health Care Facility in Amsterdam, the Netherlands Infectious Diseases in Clinical Practice 2018;26 (4):211-215

2017

  • Westerhuis Brenda M., Wiewel Maryse A., Ende Alexander Am, van der Linden Lonneke, Koekkoek Sylvie M., Wolthers Katja C., Landt Olfert A chip-based rapid genotyping assay to discriminate between rhinovirus species A, B and C Journal of clinical virology 2017;99-100:10-14 [PubMed]
  • Bruning Andrea H. L. Catching the common cold: Rapid detection and epidemiology of respiratory viruses 2017. 200p. [UvA Dissertations Online] University of Amsterdam. (Supervisors: de Jong M.D. , Kuijpers T. W.; Co-supervisors: Pajkrt D. , Wolthers K. C.)
  • Bruning Andrea H. L., de Kruijf Wilhelmina B., van Weert Henk C. P. M., Willems Wim L. M., de Jong Menno D., Pajkrt Dasja, Wolthers Katja C. Diagnostic performance and clinical feasibility of a point-of-care test for respiratory viral infections in primary health care Family practice 2017;34 (5):558-563 [PubMed]
  • de Kort Hanneke, Heutinck Kirstin M., Ruben Jurjen M., Ede V Silva Alessa, Wolthers Katja C., Hamann Jörg, ten Berge Ineke J. M. Primary Human Renal-Derived Tubular Epithelial Cells Fail to Recognize and Suppress BK Virus Infection Transplantation 2017;101 (8):1820-1829 [PubMed]
  • Bruning Andrea H. L., Leeflang Mariska M. G., Wolthers Katja C., Pajkrt Dasja Rapid Tests for Common Respiratory Viruses Reply Clinical infectious diseases 2017;65 (11):1959 [PubMed]
  • Bruning Andrea H. L., Leeflang Mariska M. G., Vos Johanna M. B. W., Spijker Rene, de Jong Menno D., Wolthers Katja C., Pajkrt Dasja Rapid Tests for Influenza, Respiratory Syncytial Virus, and Other Respiratory Viruses: A Systematic Review and Meta-analysis Clinical infectious diseases 2017;65 (6):1026-1032 [PubMed]
  • Karelehto Eveliina, van der Sanden Sabine, Geraets James A., Domanska Aušra, van der Linden Lonneke, Hoogendoorn Dionne, Koen Gerrit, van Eijk Hetty, Shakeel Shabih, Beaumont Tim, de Jong Menno, Pajkrt Dasja, Butcher Sarah J., Wolthers Katja C. Strain-dependent neutralization reveals antigenic variation of human parechovirus 3 Scientific reports 2017;7 (1):12075 [PubMed]

2016

  • van der Linden L., Bruning A. H. L., Thomas X. V., Minnaar R. P., Rebers S. P. H., Schinkel J., de Jong M. D., Pajkrt D., Wolthers K. C. A molecular epidemiological perspective of rhinovirus types circulating in Amsterdam from 2007 to 2012 Clinical microbiology and infection 2016;22 (12):1002.e9-1002.e14 [PubMed]
  • Benschop Kimberley S. M., Geeraedts Felix, Beuvink Barbara, Spit Silke A., Fanoy Ewout B., Claas Eric C. J., Pas Suzan D., Schuurman Rob, Verweij Jaco J., Bruisten Sylvia M., Wolthers Katja C., Niesters Hubert G. M., Koopmans Marion, Duizer Erwin Increase in ECHOvirus 6 infections associated with neurological symptoms in the Netherlands, June to August 2016 Euro surveillance 2016;21 (39):30351-- [PubMed]
  • Shakeel Shabih, Westerhuis Brenda M., Domanska Ausra, Koning Roman I., Matadeen Rishi, Koster Abraham J., Bakker Arjen Q., Beaumont Tim, Wolthers Katja C., Butcher Sarah J. Multiple capsid-stabilizing interactions revealed in a high-resolution structure of an emerging picornavirus causing neonatal sepsis Nature communications 2016;7:11387 [PubMed]
  • Ludlow Martin, Kortekaas Jeroen, Herden Christiane, Hoffmann Bernd, Tappe Dennis, Trebst Corinna, Griffin Diane E., Brindle Hannah E., Solomon Tom, Brown Alan S., van Riel Debby, Wolthers Katja C., Pajkrt Dasja, Wohlsein Peter, Martina Byron E. E., Baumgärtner Wolfgang, Verjans Georges M., Osterhaus Albert D. M. E. Neurotropic virus infections as the cause of immediate and delayed neuropathology Acta neuropathologica 2016;131 (2):159-184 [PubMed]
  • van der Sanden Sabine M. G., Koen Gerrit, van Eijk Hetty, Koekkoek Sylvie M., de Jong Menno D., Wolthers Katja C. Prediction of Protection against Asian Enterovirus 71 Outbreak Strains by Cross-neutralizing Capacity of Serum from Dutch Donors, The Netherlands Emerging infectious diseases 2016;22 (9):1562-1569 [PubMed]
  • Wildenbeest J. G., van der Schee M. P., Hashimoto S., Benschop K. S. M., Minnaar R. P., Sprikkelman A. B., Haarman E. G., van Aalderen W. M. C., Sterk P. J., Pajkrt D., Wolthers K. C. Prevalence of rhinoviruses in young children of an unselected birth cohort from the Netherlands Clinical microbiology and infection 2016;22 (8):736.e9-736.e15 [PubMed]
  • Wildenbeest Joanne G., Benschop Kimberley S. M., Bouma-de Jongh Saskia, Wolthers Katja C., Pajkrt Dasja Prolonged Shedding of Human Parechovirus in Feces of Young Children after Symptomatic Infection Pediatric infectious disease journal 2016;35 (5):580-583 [PubMed]
  • Benschop Kimberley S. M., Rahamat-Langendoen Janette C., van der Avoort Harrie G. A. M., Claas Eric C. J., Pas Suzan D., Schuurman Rob, Verweij Jaco J., Wolthers Katja C., Niesters Hubert G. M., Koopmans Marion P. G. VIRO-TypeNed, systematic molecular surveillance of enteroviruses in the Netherlands between 2010 and 2014 Euro surveillance 2016;21 (39):30352-- [PubMed]

2015

  • Bruning Andrea H. L., van der Sanden Sabine M. G., ten Hoedt Amber E., Wolthers Katja C., van Kaam Anton H., Pajkrt Dasja An atypical course of coxsackievirus A6 associated hand, foot and mouth disease in extremely low birth weight preterm twins Journal of clinical virology 2015;65:20-22 [PubMed]
  • Hofstra J. J., Matamoros S., van de Pol M. A., de Wever B., Tanck M. W., Wendt-Knol H., Deijs M., van der Hoek L., Wolthers K. C., Molenkamp R., Visser C. E., Sterk P. J., Lutter R., de Jong M. D. Changes in microbiota during experimental human Rhinovirus infection BMC infectious diseases 2015;15:336 [PubMed]
  • Bruning Andrea H. L., Thomas Xiomara V., van der Linden Lonneke, Wildenbeest Joanne G., Minnaar René P., Jansen Rogier R., de Jong Menno D., Sterk Peter J., van der Schee Marc P., Wolthers Katja C., Pajkrt Dasja Clinical, virological and epidemiological characteristics of rhinovirus infections in early childhood: A comparison between non-hospitalised and hospitalised children Journal of clinical virology 2015;73:120-126 [PubMed]
  • Benschop K. S. M., Wildenbeest J. G., Koen G., Minnaar R. P., van Hemert F. J., Westerhuis B. M., Pajkrt D., van den Broek P. J., Vossen A. C. T. M., Wolthers K. C. Genetic and antigenic structural characterization for resistance of echovirus 11 to pleconaril in an immunocompromised patient Journal of general virology 2015;96 (Part 3):571-579 [PubMed]
  • Westerhuis B. M., Benschop K. S. M., Koen G., Claassen Y. B., Wagner K., Bakker A. Q., Wolthers K. C., Beaumont T. Human Memory B Cells Producing Potent Cross-Neutralizing Antibodies against Human Parechovirus: Implications for Prevalence, Treatment, and Diagnosis Journal of virology 2015;89 (15):7457-7464 [PubMed]
  • van der Linden Lonneke, Wolthers Katja C., van Kuppeveld Frank J. M. Replication and Inhibitors of Enteroviruses and Parechoviruses Viruses 2015;7 (8):4529-4562 [PubMed]
  • Shakeel Shabih, Westerhuis Brenda M., Ora Ari, Koen Gerrit, Bakker Arjen Q., Claassen Yvonne, Wagner Koen, Beaumont Tim, Wolthers Katja C., Butcher Sarah J. Structural Basis of Human Parechovirus Neutralization by Human Monoclonal Antibodies Journal of virology 2015;89 (18):9571-9580 [PubMed]

2014

  • Wildenbeest J. G., Benschop K. S. M., Minnaar R. P., Bouma-de Jongh S., Wolthers K. C., Pajkrt D. Clinical relevance of positive human parechovirus type 1 and 3 PCR in stool samples Clinical microbiology and infection 2014;20 (10):O640-O647 [PubMed]
  • Bruning Andrea H. L., van Dijk Karin, van Eijk Hetty W. M., Koen Gerrit, van Woensel Job B. M., Kruisinga Frea H., Pajkrt Dasja, Wolthers Katja C. Evaluation of a rapid antigen detection point-of-care test for respiratory syncytial virus and influenza in a pediatric hospitalized population in the Netherlands Diagnostic microbiology and infectious disease 2014;80 (4):292-293 [PubMed]
  • Majoor Christof J., van de Pol Marianne A., Kamphuisen Pieter Willem, Meijers Joost C. M., Molenkamp Richard, Wolthers Katja C., van der Poll Tom, Nieuwland Rienk, Johnston Sebastian L., Sterk Peter J., Bel Elisabeth H. D., Lutter Rene, van der Sluijs Koenraad F. Evaluation of coagulation activation after rhinovirus infection in patients with asthma and healthy control subjects: an observational study Respiratory research 2014;15 (1):14 [PubMed]
  • Wildenbeest Joanne Geraldine Human enteroviruses and parechoviruses: Disease spectrum and need for treatment in young children 2014. 237p. ISBN 9789461088567. [UvA Dissertations Online] University of Amsterdam. (Supervisors: de Jong M. D., Kuijpers T. W.; Co-supervisors: Pajkrt D., Wolthers K. C.)
  • Wolthers Katja C., de Jong Menno D. Is enterovirus 71-vaccinatie ook nodig in Nederland? Nederlands tijdschrift voor geneeskunde 2014;158:A7674 [PubMed]
  • Murk J. L., de Vries A. C., GeurtsvanKessel C. H., Aron G., Osterhaus A. D., Wolthers K. C., Fraaij P. L. Persistent spiking fever in a child with acute myeloid leukemia and disseminated infection with enterovirus Journal of clinical virology 2014;61 (3):453-455 [PubMed]
  • Janes V. A., Minnaar R., Koen G., van Eijk H., Dijkman-de Haan K., Pajkrt D., Wolthers K. C., Benschop K. S. Presence of human non-polio enterovirus and parechovirus genotypes in an Amsterdam hospital in 2007 to 2011 compared to national and international published surveillance data: a comprehensive review Euro surveillance 2014;19 (46):15-23 [PubMed]
  • Westerhuis Brenda Mirande The 3-dimensional play of human parechovirus infection: Cell, virus and antibody 2014. 177p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: de Jong M. D.; Co-supervisor: Wolthers K. C.)
  • Benschop Kimberley S. M., Wolthers Katja C. The need for concerted action against the cousins of poliovirus Future Virology 2014;9 (6):541-543

2013

  • Koopmans M., Niesters H. G., Benschop K., Wolthers K., Schuurman R., Pas S. D., Claas E. C., Kroneman A., Rahamat-Langendoen J. C., Vennema H., van der Avoort H. Authors' reply: Application of Bayesian methods to the inference of phylogeny for enterovirus surveillance Euro surveillance 2013;18 (9):21 20410-22
  • Westerhuis Brenda M., Jonker Sara C. M., Mattao Sandhia, Benschop Kimberley S. M., Wolthers Katja C. Growth characteristics of human parechovirus 1 to 6 on different cell lines and cross- neutralization of human parechovirus antibodies: a comparison of the cytopathic effect and real time PCR Virology journal 2013;10:146 [PubMed]
  • Baan Elly, van der Sluis Renée M., Bakker Margreet E., Bekker Vincent, Pajkrt Dasja, Jurriaans Suzanne, Kuijpers Taco W., Berkhout Ben, Wolthers Katja C., Paxton William A., Pollakis Georgios Human immunodeficiency virus type 1 gp120 envelope characteristics associated with disease progression differ in family members infected with genetically similar viruses Journal of general virology 2013;94 (1):20-29 [PubMed]
  • Westerhuis Brenda, Kolehmainen Pekka, Benschop Kimberley, Nurminen Noora, Koen Gerrit, Koskiniemi Marjaleena, Simell Olli, Knip Mikael, Hyöty Heikki, Wolthers Katja, Tauriainen Sisko Human parechovirus seroprevalence in Finland and the Netherlands Journal of clinical virology 2013;58 (1):211-215 [PubMed]
  • Niesters H. G., Rossen J. W., van der Avoort H., Baas D., Benschop K., Claas E. C., Kroneman A., van Maarseveen N., Pas S., van Pelt W., Rahamat-Langendoen J. C., Schuurman R., Vennema H., Verhoef L., Wolthers K., Koopmans M. Laboratory-based surveillance in the molecular era: the TYPENED model, a joint data-sharing platform for clinical and public health laboratories Euro surveillance 2013;18 (4):20387-56 [PubMed]
  • Brouwer Matthijs C., Jim Kin K., Benschop Kimberley S., Wolthers Katja C., van der Ende Arie, de Jong Menno D., van de Beek Diederik No evidence of viral coinfection in cerebrospinal fluid from patients with community-acquired bacterial meningitis Journal of infectious diseases 2013;208 (1):182-184 [PubMed]
  • Leendertse Masja, van Vugt Michèle, Benschop Kimberley S., van Dijk Karin, Minnaar Rene P., van Eijk Hetty W. M., Hodiamont Caspar J., Wolthers Katja C. Pleurodynia caused by an echovirus 1 brought back from the tropics Journal of clinical virology 2013;58 (2):490-493 [PubMed]
  • Wildenbeest Joanne G., Wolthers Katja C., Straver Bart, Pajkrt Dasja Successful IVIG Treatment of Human Parechovirus-Associated Dilated Cardiomyopathy in an Infant Pediatrics 2013;132 (1):E243-E247 [PubMed]
  • van der Sluijs Koenraad F., van de Pol Marianne A., Kulik Wim, Dijkhuis Annemiek, Smids Barbara S., van Eijk Hetty W., Karlas Jos A., Molenkamp Richard, Wolthers Katja C., Johnston Sebastian L., van der Zee Jaring S., Sterk Peter J., Lutter René, Berger Marieke, Fens Niki, Yick David, Wagener Ariane H., Amelink Marijke, Reesink Herre J., Bresser Paul, Kunst Peter W. A., Venekamp Lisette N., Majoor Christof J., van Steenwijk Reindert P., Jonkers René E. Systemic tryptophan and kynurenine catabolite levels relate to severity of rhinovirus-induced asthma exacerbation: a prospective study with a parallel-group design Thorax 2013;68 (12):1122-1130 [PubMed]

2012

  • van den Berg-van de Glind Gretha J., de Vries Jutte J. C., Wolthers Katja C., Wiggers-de Bruine Francisca T., Peeters-Scholte Cacha M. P. C. D., van den Hende Muriel, van Wezel-Meijler Gerda A fatal course of neonatal meningo-encephalitis Journal of clinical virology 2012;55 (2):91-94 [PubMed]
  • McLeish Nigel J., Witteveldt Jeroen, Clasper Lucy, McIntyre Chloe, McWilliam Leitch E. Carol, Hardie Alison, Bennett Susan, Gunson Rory, Carman William F., Feeney Susan A., Coyle Peter V., Vipond Barry, Muir Peter, Benschop Kimberley, Wolthers Katja, Waris Matti, Osterback Riikka, Johannessen Ingo, Templeton Kate, Harvala Heli, Simmonds Peter Development and Assay of RNA Transcripts of Enterovirus Species A to D, Rhinovirus Species A to C, and Human Parechovirus: Assessment of Assay Sensitivity and Specificity of Real-Time Screening and Typing Methods Journal of clinical microbiology 2012;50 (9):2910-2917 [PubMed]
  • Minnaar R. P., Koen G., de Haan K., Wolthers K. C., Benschop K. S. M. Evaluation of two (semi-)nested VP1 based-PCRs for typing enteroviruses directly from cerebral spinal fluid samples Journal of virological methods 2012;185 (2):228-233 [PubMed]
  • Benschop Kimberley, Wildenbeest Joanne, Pajkrt Dasja, Wolthers Katja Human Parechoviruses, New Players in the Pathogenesis of Viral Meningitisin: George Wireko-Brobby, editors. Meningitis. S.l.: InTech; 2012. p. 145-162, ISBN 9789535103837
  • Wildenbeest Joanne G., van den Broek Peterhans J., Benschop Kimberley S. M., Koen Gerrit, Wierenga Peter C., Vossen Ann C. T. M., Kuijpers Taco W., Wolthers Katja C. Pleconaril revisited: clinical course of chronic enteroviral meningoencephalitis after treatment correlates with in vitro susceptibility Antiviral therapy 2012;17 (3):459-466 [PubMed]
  • de Vries Jutte J. C., van der Eijk Annemiek A., Wolthers Katja C., Rusman Lisette G., Pas Suzan D., Molenkamp Richard, Claas Eric C., Kroes Aloys C. M., Vossen Ann C. T. M. Real-time PCR versus viral culture on urine as a gold standard in the diagnosis of congenital cytomegalovirus infection Journal of clinical virology 2012;53 (2):167-170 [PubMed]
  • Westerhuis Brenda M., Koen Gerrit, Wildenbeest Joanne G., Pajkrt Dasja, de Jong Menno D., Benschop Kimberley S. M., Wolthers Katja C. Specific cell tropism and neutralization of human parechovirus types 1 and 3: implications for pathogenesis and therapy development Journal of general virology 2012;93 (11):2363-2370 [PubMed]

2011

  • Menting Sandra, Thai Khoa T. D., Nga Tran T. T., Phuong Hoang L., Klatser Paul, Wolthers Katja C., Binh Tran Q., de Vries Peter J., Beld Marcel Internally controlled, generic real-time PCR for quantification and multiplex real-time PCR with serotype-specific probes for serotyping of dengue virus infections Advances in virology 2011;2011:514681 [PubMed]
  • Jurriaans Suzanne, Back Nicole K. T., Wolthers Katja C. Ten years of HIV testing with fourth generation assays: the Amsterdam experience Journal of clinical virology 2011;52 (Suppl. 1):S67-S69 [PubMed]

2010

  • Benschop K. S. M., de Vries M., Minnaar R. P., Stanway G., van der Hoek L., Wolthers K. C., Simmonds P. Comprehensive full-length sequence analyses of human parechoviruses: diversity and recombination Journal of general virology 2010;91 (Part 1):145-154 [PubMed]
  • Benschop Kimberley, Minnaar Rene, Koen Gerrit, van Eijk Hetty, Dijkman Karen, Westerhuis Brenda, Molenkamp Richard, Wolthers Katja Detection of human enterovirus and human parechovirus (HPeV) genotypes from clinical stool samples: polymerase chain reaction and direct molecular typing, culture characteristics, and serotyping Diagnostic microbiology and infectious disease 2010;68 (2):166-173 [PubMed]
  • van Houdt R., Bruisten S. M., Geskus R. B., Bakker M., Wolthers K. C., Prins M. [= Maria], Coutinho R. A. Ongoing transmission of a single hepatitis B virus strain among men having sex with men in Amsterdam Journal of viral hepatitis 2010;17 (2):108-114 [PubMed]
  • Harvala Heli, Wolthers Katja C., Simmonds Peter Parechoviruses in children: understanding a new infection Current opinion in infectious diseases 2010;23 (3):224-230 [PubMed]
  • Calvert J., Chieochansin T., Benschop K. S., McWilliam Leitch E. C., Drexler J. F., Grywna K., da Costa Ribeiro H., Drosten C., Harvala H., Poovorawan Y., Wolthers K. C., Simmonds P. Recombination dynamics of human parechoviruses: investigation of type-specific differences in frequency and epidemiological correlates Journal of general virology 2010;91 (Part 5):1229-1238 [PubMed]
  • Wildenbeest Joanne G., Harvala Heli, Pajkrt Dasja, Wolthers Katja C. The need for treatment against human parechoviruses: how, why and when? Expert review of anti-infective therapy 2010;8 (12):1417-1429 [PubMed]

2009

  • Benschop Kimberley S. M. Clinical and molecular insights into human parechovirus infection 2009. 217p. ISBN 9789088911125. [UvA Dissertations Online] University of Amsterdam. (Supervisors: de Jong M. D., Vandenbroucke-Grauls C. M. J. E.; Co-supervisor: Wolthers K. C.)
  • Pajkrt Dasja, Benschop Kimberley S. M., Westerhuis Brenda, Molenkamp Richard, Spanjerberg Louise, Wolthers Katja C. Clinical Characteristics of Human Parechoviruses 4-6 Infections in Young Children Pediatric infectious disease journal 2009;28 (11):1008-1010 [PubMed]
  • van Houdt Robin, van den Berg Charlotte H. S. B., Stolte Ineke G., Bruisten Sylvia M., Dukers Nicole H. T. M., Bakker Margreet, Wolthers Katja C., Prins Maria, Coutinho Roel A. Two Decades of Hepatitis B Infections Among Drug Users in Amsterdam: Are They Still a High-Risk Group? Journal of medical virology 2009;81 (7):1163-1169 [PubMed]

2008

  • van Binnendijk Robert S., Hahné Susan, Timen Aura, van Kempen Gijs, Kohl Robert H. G., Boot Hein J., Wolthers Katja C., Wetsteijn José C. F. M., de Vries Anne, Westert Krista, Brown Kevin E., de Swart Rik L. Air travel as a risk factor for introduction of measles in a highly vaccinated population Vaccine 2008;26 (46):5775-5777 [PubMed]
  • Wetsteyn J. C. F. M., de Rond W. M. J., Schreuder M. C. J., de Boer H. E. L., van Binnendijk R. S., Wolthers K. C. Een uitbraak van mazelen op de Spoedeisende Hulp Nederlands tijdschrift voor geneeskunde 2008;152 (37):2032-2036 [PubMed]
  • Harvala H., Robertson I., Leitch E. C. McWilliam, Benschop K., Wolthers K. C., Templeton K., Simmonds P. Epidemiology and clinical associations of human parechovirus respiratory infections Journal of clinical microbiology 2008;46 (10):3446-3453 [PubMed]
  • Benschop K., Thomas X., Serpenti C., Molenkamp R., Wolthers K. High prevalence of Human Parechovirus (HPeV) genotypes in the Amsterdam region and the identification of specific HPeV variants by direct genotyping of stool samples Journal of clinical microbiology 2008;46 (12):3965-3970 [PubMed]
  • Benschop K. S. M., Wolthers K. C. Humane Parechovirussen, niet te missen Nederlands tijdschrift voor medische microbiologie 2008;16 (4):9-12
  • Wolthers Katja C., Benschop Kimberley S. M., Schinkel Janke, Molenkamp Richard, Bergevoet Rosemarijn M., Spijkerman Ingrid J. B., Kraakman H. Carlijn, Pajkrt Dasja Human parechoviruses as an important viral cause of sepsislike illness and meningitis in young children Clinical infectious diseases 2008;47 (3):358-363 [PubMed]
  • Benschop K., Stanway G., Wolthers K. C. New Human Parechoviruses: six and countingin: W. M. Scheld, Scott M. Hammer, James M. Hughes, editors. Emerging Infections 8. S.l.: ASM; 2008. p. 53-74, ISBN 9781555814441
  • Benschop Kimberley, Molenkamp Richard, van der Ham Alwin, Wolthers Katja, Beld Marcel Rapid detection of human parechoviruses in clinical samples by real-time PCR Journal of clinical virology 2008;41 (2):69-74 [PubMed]
  • Benschop K. S. M., Williams C. H., Wolthers K. C., Stanway G., Simmonds P. Widespread recombination within human parechoviruses: analysis of temporal dynamics and constraints Journal of general virology 2008;89 (Part 4):1030-1035 [PubMed]

2007

  • van de Laar Thijs J. W., van der Bij Akke K., Prins Maria, Bruisten Sylvia M., Brinkman Kees, Ruys Thomas A., van der Meer Jan T. M., de Vries Henry J. C., Mulder Jan-Willem, van Agtmael Michiel, Jurriaans Suzanne, Wolthers Katja C., Coutinho Roel A. Increase in HCV incidence among men who have sex with men in Amsterdam most likely caused by sexual transmission Journal of infectious diseases 2007;196 (2):230-238 [PubMed]
  • van den Berg Charlotte H. S. B., Smit Colette, Bakker Margreet, Geskus Ronald B., Berkhout Ben, Jurriaans Suzanne, Coutinho Roel A., Wolthers Katja C., Prins Maria Major decline of hepatitis C virus incidence rate over two decades in a cohort of drug users European journal of epidemiology 2007;22 (3):183-193 [PubMed]
  • Wolthers K. C., Jurriaans S. Valkuilen in de diagnostiek van het humaan immunodeficiëntievirus (HIV) Nederlands tijdschrift voor medische microbiologie 2007;15:7-11

2006

  • Benschop Kimberley S. M., Schinkel Janke, Luken Manon E., van den Broek Peter J. M., Beersma Matthias F. C., Menelik Negassi, van Eijk Hetty W. M., Zaaijer Hans L., Vandenbroucke-Grauls Christina M. J. E., Beld Marcel G. H. M., Wolthers Katja C. Fourth human parechovirus serotype Emerging infectious diseases 2006;12 (10):1572-1575 [PubMed]
  • Benschop K. S. M., Schinkel J., Minnaar R. P., Pajkrt D., Spanjerberg L., Kraakman H. C., Berkhout B., Zaaijer H. L., Beld M. G. H. M., Wolthers K. C. Human parechovirus infections in Dutch children and the association between serotype and disease severity Clinical infectious diseases 2006;42 (2):204-210 [PubMed]
  • Bekker Vincent, Scherpbier Henriëtte J., Steingrover Radjin, Jurriaans Suzanne, Lange Joep M. A., Wolthers Katja C., Kuijpers Taco W. Viral dynamics after starting first-line HAART in HIV-1-infected children AIDS (London, England) 2006;20 (4):517-523 [PubMed]

2004

  • Prins J. M., Wolthers K. C. Human metapneumovirus: a new pathogen in children and adults Netherlands journal of medicine 2004;62 (6):177-179 [PubMed]
  • van der Hoek Lia, Pyrc Krzysztof, Jebbink Maarten F., Vermeulen-Oost Wilma, Berkhout Ron J. M., Wolthers Katja C., Wertheim-van Dillen Pauline M. E., Kaandorp Jos, Spaargaren Joke, Berkhout Ben Identification of a new human coronavirus Nature medicine 2004;10 (4):368-373 [PubMed]
  • Verhave Menno, Krasinski Stephen D., Christian Sara I., van Schaik Sandrijn, van den Brink Gijs R., Doting Edwina M. H., Maas Saskia M., Wolthers Katja C., Grand Richard J., Montgomery Robert K. Regulatory regions in the rat lactase-phlorizin hydrolase gene that control cell-specific expression Journal of pediatric gastroenterology and nutrition 2004;39 (3):275-285 [PubMed]

2003

  • Wolthers Katja C., Kornelisse René F., Platenkamp Gert J. J. M., Schuurman-van der Lem M. Inge, van der Schee Cindy, Hartwig Nico G., Verduin Cees M. A case of Mycoplasma hominis meningo-encephalitis in a full-term infant: rapid recovery after start of treatment with ciprofloxacin European journal of pediatrics 2003;162 (7-8):514-516 [PubMed]
  • Fraaij Pieter L., van Rossum Annemarie M., Wolthers Katja C., Vossen Ann C., Jeucken Yvonne M., Kuijpers Jac H., van Lochem Ellen G., Roos Marijke T., de Groot Ronald, Hartwig Nico G. Initation of highly active antiretroviral therapy leads to an HIV-specific immune response in a seronegative infant AIDS (London, England) 2003;17 (1):138-140 [PubMed]

2002

  • van Baarle Debbie, Wolthers Katja C., Hovenkamp Egbert, Niesters Hubert G. M., Osterhaus Albert D. M. E., Miedema Frank, van Oers Marinus H. J. Absolute level of Epstein-Barr virus DNA in human immunodeficiency virus type 1 infection is not predictive of AIDS-related non-Hodgkin lymphoma Journal of infectious diseases 2002;186 (3):405-409 [PubMed]

2001

  • van Baarle D., Hovenkamp E., Callan M. F., Wolthers K. C., Kostense S., Tan L. C., Niesters H. G., Osterhaus A. D., McMichael A. J., van Oers M. H., Miedema F. Dysfunctional Epstein-Barr virus (EBV)-specific CD8(+) T lymphocytes and increased EBV load in HIV-1 infected individuals progressing to AIDS-related non-Hodgkin lymphoma Blood 2001;98 (1):146-155 [PubMed]
  • van Esser J. W., Niesters H. G., Thijsen S. F., Meijer E., Osterhaus A. D., Wolthers K. C., Boucher C. A., Gratama J. W., Budel L. M., van der Holt B., van Loon A. M., Löwenberg B., Verdonck L. F., Cornelissen J. J. Molecular quantification of viral load in plasma allows for fast and accurate prediction of response to therapy of Epstein-Barr virus-associated lymphoproliferative disease after allogeneic stem cell transplantation British journal of haematology 2001;113 (3):814-821 [PubMed]
  • Wolthers K. C., de Roda Husman A. M. The Amsterdam Cohort Studies on HIV infection and AIDS: a summary of the results 1996-2000Amsterdam: s.n.; 2001. 74p. ISBN 9789090155067
  • van Rossum A. M., Scherpbier H. J., van Lochem E. G., Pakker N. G., Slieker W. A., Wolthers K. C., Roos M. T., Kuijpers J. H., Hooijkaas H., Hartwig N. G., Geelen S. P., Wolfs T. F., Lange J. M., Miedema F., de Groot R. Therapeutic immune reconstitution in HIV-1-infected children is independent of their age and pretreatment immune status AIDS (London, England) 2001;15 (17):2267-2275 [PubMed]

2000

  • Niesters H. G., van Esser J., Fries E., Wolthers K. C., Cornelissen J., Osterhaus A. D. Development of a real-time quantitative assay for detection of Epstein-Barr virus Journal of clinical microbiology 2000;38 (2):712-715 [PubMed]
  • Clark Dawn R., Wolthers Katja C. T cell dynamics and renewal in HIV-1 infectionin: Hanneke Schuitemaker, Frank Miedema, editors. AIDS pathogenesis. Amsterdam: Kluwer; 2000. p. 55-64, ISBN 9780792361961

1999

  • Hamann D., Kostense S., Wolthers K. C., Otto S. A., Baars P. A., Miedema F., van Lier R. A. Evidence that human CD8+CD45RA+CD27- cells are induced by antigen and evolve through extensive rounds of division International immunology 1999;11 (7):1027-1033 [PubMed]
  • Wolthers K. C., Otto S. A., Wisman G. B., Fleury S., Reiss P., ten Kate R. W., van der Zee A. G., Miedema F. Normal T-cell telomerase activity and upregulation in human immunodeficiency virus-1 infection Blood 1999;93 (3):1011-1019 [PubMed]
  • Wolthers K. C., Noest A. J., Otto S. A., Miedema F., de Boer R. J. Normal telomere lengths in naive and memory CD4+ T cells in HIV type 1 infection: a mathematical interpretation AIDS research and human retroviruses 1999;15 (12):1053-1062 [PubMed]
  • Clark D. R., de Boer R. J., Wolthers K. C., Miedema F. T cell dynamics in HIV-1 infection Advances in immunology 1999;73:301-327 [PubMed]

1998

  • Fleury S., de Boer R. J., Rizzardi G. P., Wolthers K. C., Otto S. A., Welbon C. C., Graziosi C., Knabenhans C., Soudeyns H., Bart P. A., Gallant S., Corpataux J. M., Gillet M., Meylan P., Schnyder P., Meuwly J. Y., Spreen W., Glauser M. P., Miedema F., Pantaleo G. Limited CD4+ T-cell renewal in early HIV-1 infection: effect of highly active antiretroviral therapy Nature medicine 1998;4 (7):794-801 [PubMed]
  • Wolthers K. C., Schuitemaker H., Miedema F. Rapid CD4+ T-cell turnover in HIV-1 infection: a paradigm revisited Immunology today 1998;19 (1):44-48 [PubMed]
  • Wolthers K. C., Miedema F. Telomeres and HIV-1 infection: in search of exhaustion Trends in microbiology 1998;6 (4):144-147 [PubMed]

1997

  • Wolthers K. C., Otto S. A., Lens S. M., van Lier R. A., Miedema F., Meyaard L. Functional B cell abnormalities in HIV type 1 infection: role of CD40L and CD70 AIDS research and human retroviruses 1997;13 (12):1023-1029 [PubMed]

1996

  • Wolthers K. C., Otto S. A., Lens S. M., Kolbach D. N., van Lier R. A., Miedema F., Meyaard L. Increased expression of CD80, CD86 and CD70 on T cells from HIV-infected individuals upon activation in vitro: regulation by CD4+ T cells European journal of immunology 1996;26 (8):1700-1706 [PubMed]
  • Wolthers K. C., Bea G., Wisman A., Otto S. A., de Roda Husman A. M., Schaft N., de Wolf F., Goudsmit J., Coutinho R. A., van der Zee A. G., Meyaard L., Miedema F. T cell telomere length in HIV-1 infection: no evidence for increased CD4+ T cell turnover Science 1996;274 (5292):1543-1547 [PubMed]

1995

  • Meyaard L., Kuiper H., Otto S. A., Wolthers K. C., van Lier R. A., Miedema F. Evidence for intact costimulation via CD28 and CD27 molecules in hyporesponsive T cells from human immunodeficiency virus-infected individuals European journal of immunology 1995;25 (1):232-237 [PubMed]