M. Konigs PhD publications

foto

Publications PhD M. Konigs

Position
Medical Specialist
Main activities
Research
Specialisation
Pediatric Neuroscientist
Focus of research

Clinical Neuroscience in Children
Together with prof. dr. Jaap Oosterlaan, dr. Marsh Königs initiates and supervises neuroscientific research in the field of pediatrics. This research is focused on the impact of disease and intervention on the structure and function of the child’s brain. Dr. Königs specializes in the use and development of computerized neurocognitive tests, advanced analysis of neurocognitive test performance, eye-tracking and advanced magnetic resonance imaging of brain connectivity. The ultimate goal of his work is to contribute to clinical practice through (i) a better understanding of impairment mechanisms, (ii) improved outcome prediction (e.g. development of prognostic models using machine learning algorithms), (iii) evaluation of treatment efficacy in existing and novel interventions and (iv) development of outcome measures (e.g. neurocognitive test development).

Advanced Computerized Neurocognitive Testing
Dr. Königs specializes in the use and development of computerized neurocognitive tests and advanced analysis of task performance (e.g. Ex-Gaussian analysis, diffusion model analysis). Work in progress is Emma's Toolbox, an in-house designed battery of computerized tests to measure neurocognitive functions in children. Emma’s Toolbox involves a fixed core battery that uses parametric difficulty manipulation and built-in contrast conditions to isolate neurocognitive processes in the following domains: information processing, attention, learning and memory, executive functioning, sensory functioning and motor functioning. The core battery can be expanded with modules for further assessment of specific neurocognitive functions of interest, such as emotion recognition, language or visual short term memory. Emma’s Toolbox is an expanding battery: new modules become available by continuous test development.

Magnetic Resonance Imaging (MRI) of Brain Connectivity
Advanced MRI sequences are used to study the impact of disease and treatment on white matter integrity and brain connectivity. Based on diffusion tensor imaging, tract-based statistics is used to study white matter integrity, while structural connectivity is studied by probabilistic fiber tracking in combination with graph theory. Resting-state functional MRI is used to measure functional brain connectivity, using independent component analysis of resting-state networks as well as graph theory.

Projects
• Currently, dr. Königs is involved in the following projects:
• Long term neurocognitive follow-up of a large multicenter cohort of children with mild TBI (n ~ 1000). In collaboration with Nicky Niele (VU Medisch Centrum), Frans Plötz (Tergooi Ziekenhuis) and Marlies van Houten (Spaarne Gasthuis).
• Concussion Management of amateur and elite soccer players at AFC Ajax and the Royal Dutch Football Association (KNVB). Daily supervisor of PhD candidate Shari Langdon (MSc) in a study on heading and concussion in amateur and elite soccer players.
• Implementation of a prospective long-term follow-up program (Follow Me) for the Pediatric Intensive Care Unit (PICU). Daily supervisor of Noor de Sonnaville MD in a study on long-term outcome of sedation in children.
• The impact of aerobic and cognitive demanding activity on child development, a cluster-randomized controlled trials in in primary school children (N ~ 1000). Daily supervisor of one of the three PhD candidates (Anna Meijer, MSc) in a study on the impact of physical activity on brain development and neurocognitive functioning.
• Very long-term follow-up (15 years) of white matter integrity and neurocognitive functioning in children with traumatic brain injury. Collaboration with Sophie Lijdsman (Emma Children’s Hospital) and Celia Godfrey, Cathy Catroppa and Vicki Anderson (Murdoch Children’s Research Center, Melbourne Australia).
• ‘Reconstructing the Brain’s Network’, organizing a lecture and masterclass on brain network reconstruction and analysis. Collaboration with Prof. dr. David Sharp (Imperial College London, United Kingdom).

Commissions
• Member of the National Workgroup for Acquired Brain Injury in Youth (HEJ!)

 

2021

  • de Kieviet Jorrit F., Lustenhouwer Renee, Königs Marsh, van Elburg Ruurd M., Pouwels Petra J. W., Oosterlaan Jaap Altered structural connectome and motor problems of very preterm born children at school-age Early human development 2021;152 [PubMed]

2020

  • Meijer Anna, Königs Marsh, de Bruijn Anne G. M., Visscher Chris, Bosker Roel J., Hartman Esther, Oosterlaan Jaap Cardiovascular fitness and executive functioning in primary school-aged children Developmental science 2020 [PubMed]
  • Dennis Emily L., Caeyenberghs Karen, Asarnow Robert F., Babikian Talin, Bartnik-Olson Brenda, Bigler Erin D., Figaji Anthony, Giza Christopher C., Goodrich-Hunsaker Naomi J., Hodges Cooper B., Hoskinson Kristen R., Königs Marsh, Levin Harvey S., Lindsey Hannah M., Livny Abigail, Max Jeffrey E., Merkley Tricia L., Newsome Mary R., Olsen Alexander, Ryan Nicholas P., Spruiell Matthew S., Suskauer Stacy J., Thomopoulos Sophia I., Ware Ashley L., Watson Christopher G., Wheeler Anne L., Yeates Keith Owen, Zielinski Brandon A., Thompson Paul M., Tate David F., Wilde Elisabeth A. Challenges and opportunities for neuroimaging in young patients with traumatic brain injury: a coordinated effort towards advancing discovery from the ENIGMA pediatric moderate/severe TBI group Brain imaging and behavior 2020 [PubMed]
  • van Houdt Carolien A., van Wassenaer-Leemhuis Aleid G., Oosterlaan Jaap, Königs Marsh, Koopman-Esseboom Corine, Laarman A. R. C. leste, van Kaam Anton H., Aarnoudse-Moens Cornelieke S. H. Executive function training in very preterm children: a randomized controlled trial European child & adolescent psychiatry 2020 [PubMed]
  • van der Fels Irene M. J., de Bruijn A. G. M., Renken R. J., Königs M., Meijer A., Oosterlaan J., Kostons D. D. N. M., Visscher C., Bosker R. J., Smith J., Hartman E. Relationships between gross motor skills, cardiovascular fitness, and visuospatial working memory-related brain activation in 8- to 10-year-old children Cognitivem affective & behavioral neuroscience 2020;20 (4):842-858 [PubMed]
  • Langdon S., Königs M., Adang E. A. M. C., Goedhart E., Oosterlaan J. Subtypes of Sport-Related Concussion: a Systematic Review and Meta-cluster Analysis Sports medicine (Auckland, N.Z.) 2020;50 (10):1829-1842 [PubMed]
  • van der Fels Irene MJ, Smith Joanne, Boschker Roel J, Konigs Marsh, Königs Marsh, Oosterlaan Jaap, Visscher Chris, Hartman Esther The acute effects of two types of physical activity in physical education on response inhibition and lapses of attention in children aged 8-10 years A cluster randomized controlled trial International Journal of Sport Psychology 2020
  • Meijer Anna, Konigs Marsh, van der Fels Irene MJ, Visscher Chris, Boschker Roel J , Hartman Esther, Oosterlaan Jaap The Effects of Aerobic Versus Cognitively Demanding Exercise Interventions on Executive Functioning in School-Aged Children: A Cluster-Randomized Controlled Trial Journal of Sport and Exercise Psychology 2020
  • Meijer Anna, Königs Marsh, Vermeulen Gerben T., Visscher Chris, Bosker Roel J., Hartman Esther, Oosterlaan Jaap The effects of physical activity on brain structure and neurophysiological functioning in children: A systematic review and meta-analysis Developmental cognitive neuroscience 2020;45 [PubMed]

2019

  • Königs Marsh, Pouwels Petra Jw, Ernest van Heurn Lw, Bakx Roel, Jeroen Vermeulen R., Goslings Jc, Poll-The Bwee Tien, van der Wees Marleen, Catsman-Berrevoets Coriene E., Oosterlaan Jaap Correction to: Relevance of neuroimaging for neurocognitive and behavioral outcome after pediatric traumatic brain injury (Brain Imaging and Behavior, (2018), 12, 1, (29-43), 10.1007/s11682-017-9673-3) Brain imaging and behavior 2019;13 (4):1183 [PubMed]
  • Gouttebarge Vincent, Andersen Thor Einar, Cowie Charlotte, Goedhart Edwin, Jorstad Harald, Kemp Simon, Königs Marsh, Maas Mario, Orhant Emmanuel, Rantanen Jussi, Salo Jari, Serratosa Luis, Stokes Keith, Tol Johannes L., Verhagen Evert, Weber Alexis, Kerkhoffs Gino Monitoring the health of transitioning professional footballers: Protocol of an observational prospective cohort study BMJ Open Sport and Exercise Medicine 2019;5 (1) [PubMed]
  • van der Fels Irene M. J., Smith Joanne, de Bruijn Anne G. M., Bosker Roel J., Königs Marsh, Oosterlaan Jaap, Visscher Chris, Hartman Esther Relations between gross motor skills and executive functions, controlling for the role of information processing and lapses of attention in 8-10 year old children PLoS ONE 2019;14 (10) [PubMed]

2018

  • van Rappard Diane F., Königs Marsh, Steenweg Marjan E., Boelens Jaap Jan, Oosterlaan Jaap, van der Knaap Marjo S., Wolf Nicole I., Pouwels Petra J. W. Diffusion tensor imaging in metachromatic leukodystrophy Journal of neurology 2018;265 (3):659-668 [PubMed]
  • Königs Marsh, Pouwels Petra Jw, Ernest van Heurn L. W., Bakx Roel, Jeroen Vermeulen R., Carel Goslings J., Poll-The Bwee Tien, van der Wees Marleen, Catsman-Berrevoets Coriene E., Oosterlaan Jaap Relevance of neuroimaging for neurocognitive and behavioral outcome after pediatric traumatic brain injury Brain imaging and behavior 2018;12 (1):29-43 [PubMed]
  • Bröring Tinka, Königs Marsh, Oostrom Kim J., Lafeber Harrie N., Brugman Anniek, Oosterlaan Jaap Sensory processing difficulties in school-age children born very preterm: An exploratory study Early human development 2018;117:22-31 [PubMed]
  • Königs Marsh, Beurskens Eva A., Snoep Lian, Scherder Erik J. A., Oosterlaan Jaap The Effects of Timing and Intensity of Neurorehabilitation on Functional Outcome after Traumatic Brain Injury: a Systematic Review & Meta-Analysis Archives of physical medicine and rehabilitation 2018;99 (6):1149-1159.e1 [PubMed]

2017

  • Königs Marsh, Weeda Wouter D., van Heurn L. W. Ernest, Vermeulen R. Jeroen, Goslings J. Carel, Luitse Jan S. K., Poll-The Bwee Tien, Beelen Anita, van der Wees Marleen, Kemps Rachèl J. J. K., Catsman-Berrevoets Coriene E., Oosterlaan Jaap Pediatric traumatic brain injury affects multisensory integration Neuropsychology 2017;31 (2):137-148 [PubMed]
  • Staphorst Mira S., Benninga Marc A., Bisschoff Margriet, Bon Irma, Busschbach Jan J. V., Diederen Kay, van Goudoever Johannes B., Haarman Eric G., Hunfeld Joke A. M., Jaddoe Vincent V. W., de Jong Karin J. M., de Jongste Johan C., Kindermann Angelika, Königs Marsh, Oosterlaan Jaap, Passchier Jan, Pijnenburg Mariëlle W., Reneman Liesbeth, de Ridder Lissy, Tamminga Hyke G., Tiemeier Henning W., Timman Reinier, van de Vathorst Suzanne The child's perspective on discomfort during medical research procedures: a descriptive study BMJ open 2017;7 (7):e016077 [PubMed]
  • Königs Marsh, van Heurn L. W. Ernest, Bakx Roel, Vermeulen R. Jeroen, Goslings J. Carel, Poll-The Bwee Tien, van der Wees Marleen, Catsman-Berrevoets Coriene E., Oosterlaan Jaap, Pouwels Petra J. W. The Structural Connectome of Children With Traumatic Brain Injury Human brain mapping 2017;38 (7):3603-3614 [PubMed]

2016

  • Königs M., van Heurn L. W. E., Vermeulen R. J., Goslings J. C., Luitse J. S. K., Poll-Thé B. T., Beelen A., van der Wees M., Kemps R. J. J. K., Catsman-Berrevoets C. E., Luman M., Oosterlaan J. Feedback learning and behavior problems after pediatric traumatic brain injury Psychological medicine 2016;46 (7):1473-1484 [PubMed]
  • Königs M., Engenhorst P. J., Oosterlaan J. Intelligence after traumatic brain injury: meta-analysis of outcomes and prognosis European journal of neurology 2016;23 (1):21-29 [PubMed]
  • Königs Marsh Traumatic brain injury in children. Impact on Brain Structure, Neurocognition & Behavior 2016. 338p. [UvA Dissertations Online] Free University: Human movement sciences. (Supervisor: Oosterlaan J.)

2015

  • Königs Marsh, Weeda Wouter D., van Heurn L. W. Ernest, Vermeulen R. Jeroen, Goslings J. Carel, Luitse Jan S. K., Poll-Thé Bwee Tien, Beelen Anita, van der Wees Marleen, Kemps Rachèl J. J. K., Catsman-Berrevoets Coriene E., Oosterlaan Jaap Impaired Visual Integration in Children with Traumatic Brain Injury: An Observational Study PLoS ONE 2015;10 (12):e0144395 [PubMed]
  • Königs Marsh, Heij Hugo A., van der Sluijs Johannes A., Vermeulen R. Jeroen, Goslings J. Carel, Luitse Jan S. K., Poll-Thé Bwee Tien, Beelen Anita, van der Wees Marleen, Kemps Rachèl J. J. K., Catsman-Berrevoets Coriene E., Oosterlaan Jaap Pediatric Traumatic Brain Injury and Attention Deficit Pediatrics 2015;136 (3):534-541 [PubMed]

2014

  • Scherder Erik, Scherder Rogier, Verburgh Lot, Königs Marsh, Blom Marco, Kramer Arthur F., Eggermont Laura Executive functions of sedentary elderly may benefit from walking: A systematic review and meta-analysis American journal of geriatric psychiatry 2014;22 (8):782-791 [PubMed]
  • Scherder Erik J. A., Scherder Rogier, Verburgh L., Konigs Marsh, Blom M, Kramer A, Eggermont Laura Executive functions of sedentary elderly may benefit from walking: a systematic review and meta-analysis The American Journal of Geriatric Psychiatry 2014
  • Verburgh Lot, Königs Marsh, Scherder Erik J. A., Oosterlaan Jaap Physical exercise and executive functions in preadolescent children, adolescents and young adults: a meta-analysis British journal of sports medicine 2014;48 (12):973-+ [PubMed]

2013

  • Luttikhuizen dos Santos Elsa S., de Kieviet Jorrit F., Königs Marsh, van Elburg Ruurd M., Oosterlaan Jaap Predictive value of the Bayley scales of infant development on development of very preterm/very low birth weight children: a meta-analysis Early human development 2013;89 (7):487-496 [PubMed]

2012

  • Königs Marsh, de Kieviet Jorrit F., Oosterlaan Jaap Post-traumatic amnesia predicts intelligence impairment following traumatic brain injury: a meta-analysis Journal of neurology, neurosurgery, and psychiatry 2012;83 (11):1048-1055 [PubMed]