A.D. Bins MD PhD publications

foto

Publications MD PhD A.D. Bins

Position
Medical Specialist
Main activities
Patient care, Research
Specialisation
Medical oncology, immuno oncology
Focus of research

Our primary goal is to pioneer novel immune based preventive and curative interventions in oncology, as we strongly believe that prevention and cure are better than any palliative treatment. Our research focusses on the application of T-cell induction in prophylactic and curative oncologic treatment settings, targeting tumour specific neo-antigens. Among other activities, this involves the search for neo-antigens in mismatch repair deficient colorectal cancer patients. For that purpose my group leads a KWF granted consortium and a clinical trial sponsored by pharma . In addition my research group explores novel ways to combine ICB treatment with radiotherapy , also in the context of investigator initiated a clinical trials.

2020

  • Steenbruggen Tessa G., Steggink Lars C., Seynaeve Caroline M., van der Hoeven Jacobus J. M., Hooning Maartje J., Jager Agnes, Konings Inge R., Kroep Judith R., Smit Wim M., Tjan-Heijnen Vivianne C. G., van der Wall Elsken, Bins Adriaan D., Linn Sabine C., Schaapveld Michael, Jacobse Judy N., van Leeuwen Flora E., Schröder Carolien P., van Tinteren Harm, de Vries Elisabeth G. E., Sonke Gabe S., Gietema Jourik A. High-Dose Chemotherapy with Hematopoietic Stem Cell Transplant in Patients with High-Risk Breast Cancer and 4 or More Involved Axillary Lymph Nodes: 20-Year Follow-up of a Phase 3 Randomized Clinical Trial JAMA oncology 2020;6 (4):528-534 [PubMed]
  • Hofland Tom, Martens Anne W. J., van Bruggen Jaco A. C., de Boer Renate, Schetters Sjoerd, Remmerswaal Ester B. M., Bemelman Frederike J., Levin Mark-David, Bins Adriaan D., Eldering Eric, Kater Arnon P., Tonino Sanne H. Human CXCR5+PD-1+ CD8 T cells in healthy individuals and patients with hematologic malignancies European journal of immunology 2020 [PubMed]

2019

  • van Kalmthout Ludwike, Braat Arthur, Lam Marnix, van Leeuwaarde Rachel, Krijger Gerard, Ververs Tessa, Mehra Niven, Bins Adriaan, Hunting Jarmo, de Keizer Bart First Experience With 177Lu-PSMA-617 Therapy for Advanced Prostate Cancer in the Netherlands Clinical nuclear medicine 2019;44 (6):446-451 [PubMed]

2018

  • Steenbruggen T. G., Steggink L. C., Seynaeve C. M., van der Hoeven J. J. M., Hooning M. J., Jager A., Konings I. R., Kroep J. R., Smit W. M., Tjan-Heijnen V. C. G., van der Wall E., Bins A. D., Linn S. C., Schaapveld M., van Leeuwen F. E., Schroder C. P., van Tinteren H., de Vries E. G. E., Sonke G. S., Gietema J. A. High-dose chemotherapy (HDCT) with hematopoietic stem cell transplantation (HSCT) in high-risk breast cancer (BC) patients with ≥4 involved axillary lymph nodes (ALN): 20-year follow-up of a randomized phase 3 study Annals of oncology 2018;29:viii59 [PubMed]
  • Babała Nikolina, Bovens Astrid, de Vries Evert, Iglesias-Guimarais Victoria, Ahrends Tomasz, Krummel Matthew F., Borst Jannie, Bins Adriaan D. Subcellular localization of antigen in keratinocytes dictates delivery of CD4þ T-cell Help for the CTL response upon therapeutic DNA vaccination into the Skin Cancer immunology research 2018;6 (7):835-847 [PubMed]

2017

  • Bouman-Wammes Esther W., van Dodewaard-de Jong Joyce M., Dahele Max, Cysouw Matthijs C. F., Hoekstra Otto S., van Moorselaar R. Jeroen A., Piet Maartje A. H., Verberne Hein J., Bins Adriaan D., Verheul Henk M. W., Slotman Ben J., Oprea-Lager Daniela E., van den Eertwegh Alfons J. M. Benefits of Using Stereotactic Body Radiotherapy in Patients With Metachronous Oligometastases of Hormone-Sensitive Prostate Cancer Detected by [18F]fluoromethylcholine PET/CT Clinical genitourinary cancer 2017;15 (5):E773-E782 [PubMed]
  • Hulshof Martinus C. C. M., Leliveld-Kors Anna M., Bins Adriaan D. Blaassparende behandeling bij het spierinvasief blaascarcinoom Nederlands tijdschrift voor oncologie 2017;14 (4):132-137
  • Lankelma Jacqueline M., Wagemakers Alex, Birnie Emma, Haak Bastiaan W., Trentelman Jos J. A., Weehuizen Tassili A. F., Ersöz Jasmin, Roelofs Joris J. T. H., Hovius Joppe W., Wiersinga W. Joost, Bins Adriaan D. Rapid DNA vaccination against Burkholderia pseudomallei flagellin by tattoo or intranasal application Virulence 2017;8 (8):1683-1694 [PubMed]
  • Wagemakers Alex Tick-host-Borrelia interaction: Implications for host immunity and vaccination strategies 2017. 208p. ISBN 9789462955608. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van der Poll T.; Co-supervisors: Bins A. D., Hovius J. W. R.)

2016

  • Wagemakers Alex, Coumou Jeroen, Schuijt Tim J., Oei Anneke, Nijhof Ard M., van 't Veer Cornelis, van der Poll Tom, Bins Adriaan D., Hovius Joppe W. R. An Ixodes ricinus Tick Salivary Lectin Pathway Inhibitor Protects Borrelia burgdorferi sensu lato from Human Complement Vector borne and zoonotic diseases (Larchmont, N.Y.) 2016;16 (4):223-228 [PubMed]
  • Deken Marcel A., Song Ji-Ying, Gadiot Jules, Bins Adriaan D., Kroon Paula, Verbrugge Inge, Blank Christian U. Dermal Delivery of Constructs Encoding Cre Recombinase to Induce Skin Tumors in Pten(LoxP/LoxP);Braf(CA/+) Mice International journal of molecular sciences 2016;17 (12):2149 [PubMed]
  • Wagemakers Alex, Koetsveld Joris, Narasimhan Sukanya, Wickel Melvin, Deponte Kathleen, Bleijlevens Boris, Jahfari Seta, Sprong Hein, Karan Lyudmila S., Sarksyan Denis S., van der Poll Tom, Bockenstedt Linda K., Bins Adriaan D., Platonov Alexander E., Fikrig Erol, Hovius Joppe W. Variable Major Proteins as Targets for Specific Antibodies against Borrelia miyamotoi Journal of immunology (Baltimore, Md. 2016;196 (10):4185-4195 [PubMed]
  • Headley Mark B., Bins A. , Nip Alyssa, Roberts Edward W., Looney Mark R., Gerard Audrey, Krummel Matthew F. Visualization of immediate immune responses to pioneer metastatic cells in the lung Nature 2016;531 (7595):513-517 [PubMed]

2015

  • van den Berg Joost H., Gomez-Eerland Raquel, van de Wiel Bart, Hulshoff Lenie, van den Broek Daan, Bins Adriaan, Tan Hanno L., Harper Jane V., Hassan Namir J., Jakobsen Bent K., Jorritsma Annelies, Blank Christian U., Schumacher Ton N. M., Haanen John B. A. G. Case Report of a Fatal Serious Adverse Event Upon Administration of T Cells Transduced With a MART-1-specific T-cell Receptor Molecular therapy 2015;23 (9):1541-1550 [PubMed]

2014

  • Ortiz-Muñoz Guadalupe, Mallavia Beñat, Bins Adriaan, Headley Mark, Krummel Matthew F., Looney Mark R. Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice Blood 2014;124 (17):2625-2634 [PubMed]
  • Wagemakers A., Mason L. M. K., Oei A., de Wever B., van der Poll T., Bins A. D., Hovius J. W. R. Rapid outer-surface protein C DNA tattoo vaccination protects against Borrelia afzelii infection Gene therapy 2014;21 (12):1051-1057 [PubMed]

2013

  • Bins A. D., van den Berg J. H., Oosterhuis K., Haanen J. B. A. G. Recent advances towards the clinical application of DNA vaccines Netherlands journal of medicine 2013;71 (3):109-117 [PubMed]

2008

  • Verstrepen Babs E., Bins Adriaan D., Rollier Christine S., Mooij Petra, Koopman Gerrit, Sheppard Neil C., Sattentau Quentin, Wagner Ralf, Wolf Hans, Schumacher Ton N. M., Heeney Jonathan L., Haanen John B. A. G. Improved HIV-1 specific T-cell responses by short-interval DNA tattooing as compared to intramuscular immunization in non-human primates Vaccine 2008;26 (26):3346-3351 [PubMed]
  • Jorritsma Annelies, Bins Adriaan D., Schumacher Ton N. M., Haanen John B. A. G. Skewing the T-cell repertoire by combined DNA vaccination, host conditioning, and adoptive transfer Cancer research 2008;68 (7):2455-2462 [PubMed]

2007

  • Bins Adriaan D., van Rheenen Jacco, Jalink Kees, Halstead Jonathan R., Divecha Nullin, Spencer David M., Haanen John B. A. G., Schumacher Ton N. M. Intravital imaging of fluorescent markers and FRET probes by DNA tattooing BMC biotechnology 2007;7:2 [PubMed]
  • Bins Adriaan D., Wolkers Monika C., van den Boom Marly D., Haanen John B. A. G., Schumacher Ton N. M. In vivo antigen stability affects DNA vaccine immunogenicity Journal of immunology (Baltimore, Md. 2007;179 (4):2126-2133 [PubMed]
  • Bins Adriaan, Mallo Henk, Sein Johan, van den Bogaard Colette, Nooijen Willem, Vyth-Dreese Florry, Nuijen Bastiaan, de Gast Gijsbert C., Haanen John B. A. G. Phase I clinical study with multiple peptide vaccines in combination with tetanus toxoid and GM-CSF in advanced-stage HLA-A*0201-positive melanoma patients Journal of immunotherapy (Hagerstown, Md. 2007;30 (2):234-239 [PubMed]

2006

  • Toebes Mireille, Coccoris Miriam, Bins Adriaan, Rodenko Boris, Gomez Raquel, Nieuwkoop Nella J., van de Kasteele Willeke, Rimmelzwaan Guus F., Haanen John B. A. G., Ovaa Huib, Schumacher Ton N. M. Design and use of conditional MHC class I ligands Nature medicine 2006;12 (2):246-251 [PubMed]

2005

  • Bins Adriaan D., Jorritsma Annelies, Wolkers Monika C., Hung Chien-Fu, Wu T.-C., Schumacher Ton N. M., Haanen John B. A. G. A rapid and potent DNA vaccination strategy defined by in vivo monitoring of antigen expression Nature medicine 2005;11 (8):899-904 [PubMed]

2004

  • Bischof Felix, Bins Adriaan, Dürr Michael, Zevering Yinka, Melms Arthur, Kruisbeek Ada M. A structurally available encephalitogenic epitope of myelin oligodendrocyte glycoprotein specifically induces a diversified pathogenic autoimmune response Journal of immunology (Baltimore, Md. 2004;173 (1):600-606 [PubMed]
  • van Oijen Monique, Bins Adriaan, Elias Sjoerd, Sein Johan, Weder Pauline, de Gast Gijsbert, Mallo Henk, Gallee Maarten, van Tinteren Harm, Schumacher Ton, Haanen John On the role of melanoma-specific CD8+ T-cell immunity in disease progression of advanced-stage melanoma patients Clinical cancer research 2004;10 (14):4754-4760 [PubMed]