F. Eftimov MD PhD publications

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Publications MD PhD F. Eftimov

Positions
Other Academic Staff, Medical Specialist
Main activities
Patient care, Research
Specialisation
Neurologist, Neuromuscular disorders
Focus of research

 The Department of Neurology performs clinical and translational research within three research themes: infection & inflammation, cerebrovascular disorders, and movement disorders. The themes are imbedded in the nine translational research programs of Amsterdam Neuroscience, the research institute of neuroscience investigators in the Amsterdam area. All staff members of the Department of Neurology are involved in research and collaborate within Neuroscience Amsterdam, with other academic and non-academic hospitals, and with international research groups.
Infection & Inflammation
We perform clinical translational research in the field of neurological infections & inflammation. We perform prospective clinical cohort studies, randomized clinical trials, and experimental research, combining our clinical expertise with groundbreaking, translational approaches using clinical data, human samples, next generation sequencing, in vitro techniques, and mouse models in the era's of bacterial meningitis & encephalitis, infections after stroke, septic encephalopathy, and inflammatory diseases of peripheral nerves and muscles.
Since the completion of my Neurology training in 2012 I have been working as a neurologist, with a special interest in neuromuscular diseases and neuroimmunology. In daily practice, I see patients with all kinds of neuromuscular disease, such as motor neuron disease, myopathies, and neuropathies. My specific area of interest is chronic inflammatory demyelinating polyneuropathy (CIDP). Other areas of expertise include myositis, neurological manifestations of sarcoidosis and various inflammatory neuropathies (GBS, MMN, vasculitis). As one of GBS/CIDP Foundation centers of excellence, we seek to improve treatment in CIDP and other inflammatory neuropathies. In 2015 I finished my PhD thesis ‘Treatment of chronic inflammatory neuropathies’. Currently I am combining a translational approach to search for biomarkers of disease activity in CIDP and clinical research that focuses on long-term outcome of the disease. I am the coordinating investigator of a multicenter randomised controlled trial (IOC trial) to study overtreatment with IVIg in CIDP. In recent years I have initiated several CIDP studies and have participated in international randomised controlled trials in CIDP. As one of the initiators of the International CIDP Outcome Study (ICOS) and co-organizer of the European Neuromuscular Center workshop on international standardization of CIDP registries I hope to improve international collaboration and to contribute to discovering new treatments for this rare disease.

Amsterdam UMC Research Institutes
AMC departments
All publications

2021

  • Kuitwaard K., Brusse E., Jacobs B. C., Vrancken A. F. J. E., Eftimov F., Notermans N. C., van der Kooi A. J., Fokkink W. -J. R., Nieboer D., Lingsma H. F., Merkies I. S. J., van Doorn P. A. Randomized trial of intravenous immunoglobulin maintenance treatment regimens in chronic inflammatory demyelinating polyradiculoneuropathy European journal of neurology 2021;28 (1):286-296 [PubMed]

2020

  • Adrichem M. E., Bus S. R., Wieske L., Mohammed H., Verhamme C., Hadden R., van Schaik I. N., Eftimov F. Combined intravenous immunoglobulin and methylprednisolone as induction treatment in chronic inflammatory demyelinating polyneuropathy (OPTIC protocol): a prospective pilot study European journal of neurology 2020;27 (3):506-513 [PubMed]
  • Broers Merel C., van Doorn Pieter A., Kuitwaard Krista, Eftimov Filip, Wirtz Paul W., Goedee Stephan, Lingsma Hester F., Jacobs Bart C. Diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy in clinical practice: A survey among Dutch neurologists Journal of the peripheral nervous system 2020;25 (3):247-255 [PubMed]
  • Oudeman Jos, Eftimov Filip, Strijkers Gustav J., Schneiders Joppe J., Roosendaal Stefan D., Engbersen Maurits P., Froeling Martijn, Goedee H. Stephan, van Doorn Pieter A., Caan Matthan W. A., van Schaik Ivo N., Maas Mario, Nederveen Aart J., de Visser Marianne, Verhamme Camiel Diagnostic accuracy of MRI and ultrasound in chronic immune-mediated neuropathies Neurology 2020;94 (1):e62-e74 [PubMed]
  • Eftimov Filip, Lucke Ilse M., Querol Luis A., Rajabally Yusuf A., Verhamme Camiel Diagnostic challenges in chronic inflammatory demyelinating polyradiculoneuropathy Brain 2020;143 (11):3214-3224 [PubMed]
  • Oorschot Sander, Brehm Merel A., van Groenestijn Annerieke C., Koopman Fieke S., Verhamme Camiel, Eftimov Filip, Jelsma Judith G. M., Jorstad Harald T., Nollet Frans, Voorn Eric L. Efficacy of a physical activity programme combining individualized aerobic exercise and coaching to improve physical fitness in neuromuscular diseases (I'M FINE): study protocol of a randomized controlled trial BMC neurology 2020;20 (1):1-10 [PubMed]
  • Herraets Ingrid J. T., Goedee H. Stephan, Telleman Johan A., van Eijk Ruben P. A., Verhamme Camiel, Saris Christiaan G. J., Eftimov Filip, van Alfen Nens, van Asseldonk J. Thies, Visser Leo H., van den Berg Leonard H., van der Pol Ludo W. Nerve ultrasound for diagnosing chronic inflammatory neuropathy: A multicenter validation study Neurology 2020;95 (12):e1745-e1753 [PubMed]
  • Verboon Christine, van den Berg Bianca, Cornblath David R, Venema Esmee, Gorson Kenneth C, Lunn Michael P, Lingsma Hester, Van den Bergh Peter, Harbo Thomas, Bateman Kathleen, Pereon Yann, Sindrup Søren H, Kusunoki Susumu, Miller James, Islam Zhahirul, Hartung Hans-Peter, Chavada Govindsinh, Jacobs Bart C, Hughes Richard A C, van Doorn Pieter A, Eftimov Filip, van der Kooi A. J. Original research: Second IVIg course in Guillain-Barré syndrome with poor prognosis: The non-randomised ISID study Journal of neurology, neurosurgery, and psychiatry 2020;91 (2):113-121 [PubMed]
  • Lewis Richard A., Cornblath David R., Hartung Hans-Peter, Sobue Gens, Lawo John-Philip, Mielke Orell, Durn Billie L., Bril Vera, Merkies Ingemar S. J., Bassett Paul, Cleasby Alexa, van Schaik Ivo N., Sabet A., George K., Roberts L., Carne R., Blum S., Henderson R., van Damme P., Demeestere J., Larue S., D’Amour C., Kunc P., Valis M., Sussova J., Kalous T., Talab R., Bednar M., Toomsoo T., Rubanovits I., Gross-Paju K., Sorro U., Saarela M., Auranen M., Pouget J., Attarian S., le Masson G., Wielanek A., Desnuelle C., Delmon E., Clavelou P., Aufauvre D., Schmidt J., Zschuentzsch J., Sommer C., Kramer D., Hoffmann O., Goerlitz C., Haas J., Chatzopoulos M., Yoon R., Gold R., Berlit P., Jaspert-Grehl A., Liebetanz D., Kutschenko A., Stangel M., Trebst C., Baum P., Bergh F., Klehmet J., Meisel A., Klostermann F., Oechtering J., Lehmann H., Schroeter M., Hagenacker T., Mueller D., Sperfeld A., Bethke F., Drory Israel V., Algom A., Yarnitsky D., Murinson B., di Muzio A., Ciccocioppo F., Sorbi S., Mata S., Schenone A., Grandis M., Lauria G., Cazzato D., Antonini G., Morino S., Cocito D., Zibetti M., Yokota T., Ohkubo T., Kanda T., Kawai M., Kaida K., Onoue H., Kuwabara S., Mori M., Iijima M., Ohyama K., Baba M., Tomiyama M., Nishiyama K., Akutsu T., Yokoyama K., Kanai K., van Schaik I. N., Eftimov F., Notermans N. C., Visser N., Faber C., Hoeijmakers J., Rejdak K., Chyrchel-Paszkiewicz U., Casanovas Pons C., Antonia M., Gamez J., Salvado M., Infante C. Marquez, Benitez S., Lunn M., Morrow J., Gosal D., Lavin T., Melamed I., Testori A., Ajroud-Driss S., Menichella D., Simpson E., Lai E. Chi-Ho, Dimachkie M., Barohn R. J., Beydoun S., Johl H., Lange D., Shtilbans A., Muley S., Ladha S., Freimer M., Kissel J., Latov N., Chin R., Ubogu E., Mumfrey S., Rao T., MacDonald P., Sharma K., Gonzalez G., Allen J., Walk D., Hobson-Webb L., Gable K. Placebo effect in chronic inflammatory demyelinating polyneuropathy: The PATH study and a systematic review Journal of the peripheral nervous system 2020;25 (3):230-237 [PubMed]

2019

  • Lucke Ilse M., Wieske Luuk, van der Kooi Anneke J., van Schaik Ivo N., Eftimov Filip, Verhamme Camiel Diagnosis and treatment response in the asymmetric variant of chronic inflammatory demyelinating polyneuropathy Journal of the peripheral nervous system 2019;24 (2):174-179 [PubMed]
  • Lim J., Eftimov F., Raaphorst J., Aronica E., van der Kooi A. J. Diagnostic value of additional histopathological fascia examination in idiopathic inflammatory myopathies European journal of neurology 2019;26 (12):1494-1496 [PubMed]
  • Merkies Ingemar S. J., van Schaik Ivo N., Léger Jean-Marc, Bril Vera, van Geloven Nan, Hartung Hans-Peter, Lewis Richard A., Sobue Gen, Lawo John-Philip, Durn Billie L., Cornblath David R., de Bleecker Jan L., Sommer Claudia, Robberecht Wim, Saarela Mika, Kamienowski Jerzy, Stelmasiak Zbigniew, Tackenberg Björn, Mielke Orell, Sabet A., George K., Roberts L., Carne R., Blum S., Henderson R., van Damme P., Demeestere J., Larue S., D'Amour C., Kunc P., Valis M., Sussova J., Kalous T., Talab R., Bednar M., Toomsoo T., Rubanovits I., Gross-Paju K., Sorro U., Saarela M., Auranen M., Pouget J., Attarian S., Masson G. Le, Wielanek-Bachelet A., Desnuelle C., Delmont E., van Schaik I. N., Eftimov F., van Schaik I. N. Efficacy and safety of IVIG in CIDP: Combined data of the PRIMA and PATH studies Journal of the peripheral nervous system 2019;24 (1):48-55 [PubMed]
  • Bunschoten Carina, Eftimov Filip, van der Pol W. -Ludo, Jacobs Bart C., van Doorn P. A., Brusse E., Drenthen J., Arends S., Broers M. C., van Schaik I. N., van der Kooi A. J., Verhamme C., Adrichem M. E., van Lieverloo G. G. A., Lucke I. M., Bus S. R. M., van den Berg L. H., Notermans N. C., Vrancken A. F. J. E., Goedee H. S., Franssen H. International chronic inflammatory demyelinating polyneuropathy outcome study (ICOS): Protocol of a prospective observational cohort study on clinical and biological predictors of disease course and outcome Journal of the peripheral nervous system 2019;24 (1):34-38 [PubMed]
  • Lucke Ilse M., Adrichem Max E., Wieske Luuk, van der Kooi Anneke J., Verhamme Camiel, van Schaik Ivo N., Eftimov Filip Intravenous immunoglobulins in patients with clinically suspected chronic immune-mediated neuropathy Journal of the neurological sciences 2019;397:141-145 [PubMed]
  • Lim J., Eftimov F., Raaphorst J., Aronica E., van der Kooi A. J. Response to: Diagnostic value of additional histopathological fascia examination in idiopathic inflammatory myopathies European journal of neurology 2019;26:e95 [PubMed]
  • Mielke Orell, Bril Vera, Cornblath David R., Lawo John-Philip, van Geloven Nan, Hartung Hans-Peter, Lewis Richard A., Merkies Ingemar S. J., Sobue Gen, Durn Billie, Shebl Amgad, van Schaik Ivo N., Sabet A., George K., Roberts L., Carne R., Blum S., Henderson R., van Damme P., Demeestere J., Larue S., D'Amour C., Kunc P., Valis M., Sussova J., Kalous T., Talab R., Bednar M., Toomsoo T., Rubanovits I., Gross-Paju K., Sorro U., Saarela M., Auranen M., Pouget J., Attarian S., le Masson G., Wielanek-Bachelet A., Desnuelle C., Delmont E., Clavelou P., Aufauvre D., Schmidt J., Zschuentzsch J., Sommer C., Kramer D., Hoffmann O., van Schaik I. N., Eftimov F., van Schaik I. N. Restabilization treatment after intravenous immunoglobulin withdrawal in chronic inflammatory demyelinating polyneuropathy: Results from the pre-randomization phase of the Polyneuropathy And Treatment with Hizentra study Journal of the peripheral nervous system 2019;24 (1):72-79 [PubMed]
  • van Lieverloo Gwen G. A., Wieske Luuk, Verhamme Camiel, Vrancken Alexander F. J., van Doorn Pieter A., Michalak Zuzanna, Barro Christian, van Schaik Ivo N., Kuhle Jens, Eftimov Filip Serum neurofilament light chain in chronic inflammatory demyelinating polyneuropathy Journal of the peripheral nervous system 2019;24 (2):187-194 [PubMed]

2018

  • Eftimov Filip, Bunschoten Carina, Rajabally Yusuf, Querol Luis, Adrichem Max E., Allen Jeffrey, Antoine Jean-Cristophe, Basta Ivana, van den Bergh Peter, Blomkwist-Markens Patricia, Breukel Alexandra, Cornblath David, Doppler Kathrin, Goedee Stephan, Hadden Robert, Harbo Thomas, Hiew Fu Liong, Jacobs Bart C., Lehmann Helmar, Lunn Michael P., Merkies Ingemar S. J., Nobile-Orazio Eduardo, Reddel Stephen, Vallat Jean-Michel, Uncini Antonino 231st ENMC International Workshop:: International Standard for CIDP Registry and Biobank, Naarden, The Netherlands, 12-14 May 2017 Neuromuscular disorders 2018;28 (2):178-184 [PubMed]
  • van Lieverloo G. G. A., Peric S., Doneddu P. E., Gallia F., Nikolic A., Wieske L., Verhamme C., van Schaik I. N., Nobile-Orazio E., Basta I., Eftimov F. Corticosteroids in chronic inflammatory demyelinating polyneuropathy: A retrospective, multicentre study, comparing efficacy and safety of daily prednisolone, pulsed dexamethasone, and pulsed intravenous methylprednisolone Journal of neurology 2018;265 (9):2052-2059 [PubMed]
  • Lucke Ilse M., Peric Stojan, van Lieverloo Gwen G. A., Wieske Luuk, Verhamme Camiel, van Schaik Ivo N., Basta Ivana, Eftimov Filip Elevated leukocyte count in cerebrospinal fluid of patients with chronic inflammatory demyelinating polyneuropathy Journal of the peripheral nervous system 2018;23 (1):49-54 [PubMed]
  • van Schaik Ivo N., Mielke Orell, Sabet Arman, George Koshy, Roberts Leslie, Carne Ross, Blum Stefan, Henderson Robert, van Damme Philip, Demeestere Jelle, Larue Sandrine, Pinard D'Amour Catherine-Andree, Bril Vera, Breiner Ari, Kunc Pavel, Valis Martin, Sussova Jana, Kalous Tomas, Talab Radomir, Bednar Michal, Toomsoo Toomas, Rubanovits Inna, Gross-Paju Katrin, Sorro Ulvi, Saarela Mika, Auranen Mari, Pouget Jean, Attarian Shahram, le Masson Gwendal, Wielanek-Bachelet Anne-C. cile, Desnuelle Claude, Delmont Emilien, Clavelou Pierre, Aufauvre Dominique, Schmidt Jens, Zschuentssch Jana, Sommer Claudia, Kramer Daniela, Hoffmann Olaf, Goerlitz Carsten, Haas Judith, Chatzopoulos Marko, Yoon Min-Suk, Gold Ralf, Berlit Peter, Jaspert-Grehl Andrea, Liebetanz David, van Schaik Ivo N., Eftimov Filip, van Geloven Nan Intravenous versus subcutaneous immunoglobulin – Authors' reply Lancet neurology 2018;17 (5):393-394
  • Kuitwaard K., Fokkink W. J. R., Brusse E., Vrancken A. F. J. E., Eftimov F., Notermans N. C., van der Kooi A. J., Merkies I. S. J., Jacobs B. C., van Doorn P. A. Protocol of a dose response trial of IV immunoglobulin in chronic inflammatory demyelinating polyradiculoneuropathy (DRIP study) Journal of the peripheral nervous system 2018;23 (1):5-10 [PubMed]
  • van Schaik Ivo N., Bril Vera, van Geloven Nan, Hartung Hans-Peter, Lewis Richard A., Sobue Gen, Lawo John-Philip, Praus Michaela, Mielke Orell, Durn Billie L., Cornblath David R., Merkies Ingemar S. J., Sabet A., George K., Roberts L., Carne R., Blum S., Henderson R., van Damme P., Demeestere J., Larue S., D'Amour C., Bril V., Breiner A., Kunc P., Valis M., Sussova J., Kalous T., Talab R., Bednar M., Toomsoo T., Rubanovits I., Gross-Paju K., Sorro U., Saarela M., Auranen M., Pouget J., Attarian S., Le Masson G., Wielanek-Bachelet A., Desnuelle C., Delmont E., Clavelou P., Aufauvre D., Schmidt J., Zschuentssch J., Sommer C., Kramer D., Hoffmann O., Eftimov F. Subcutaneous immunoglobulin for maintenance treatment in chronic inflammatory demyelinating polyneuropathy (PATH): a randomised, double-blind, placebo-controlled, phase 3 trial Lancet neurology 2018;17 (1):35-46 [PubMed]

2017

  • Adrichem Max E., Starink Markus V., van Leeuwen Ester M. M., Kramer Christine, van Schaik Ivo N., Eftimov Filip Drug-induced cutaneous lupus erythematosus after immunoglobulin treatment in chronic inflammatory demyelinating polyneuropathy: a case series Journal of the peripheral nervous system 2017;22 (3):213-218 [PubMed]
  • McLaughlin Russell L., Schijven Dick, van Rheenen Wouter, van Eijk Kristel R., O'Brien Margaret, Kahn René S., Ophoff Roel A., Goris An, Bradley Daniel G., Al-Chalabi Ammar, van den Berg Leonard H., Luykx Jurjen J., Hardiman Orla, Veldink Jan H., Shatunov Aleksey, Dekker Annelot M., Diekstra Frank P., Pulit Sara L., van der Spek Rick A. A., van Doormaal Perry T. C., Sproviero William, Jones Ashley R., Nicholson Garth A., Rowe Dominic B., Pamphlett Roger, Kiernan Matthew C., Bauer Denis, Kahlke Tim, Williams Kelly, Eftimov Filip, Fogh Isabella, Ticozzi Nicola, Lin Kuang, Millecamps Stéphanie, Salachas François, Meininger Vincent, de Carvalho Mamede, Pinto Susana, Mora Jesus S., Rojas-García Ricardo, Polak Meraida, Chandran Siddharthan, Colville Shuna, Swingler Robert, Morrison Karen E., Shaw Pamela J., Hardy John, van der Kooi Anneke J., Weber Markus, de Haan Lieuwe Genetic correlation between amyotrophic lateral sclerosis and schizophrenia Nature communications 2017;8:14774 [PubMed]
  • Kuitwaard Krista, Fokkink Willem-Jan R., Brusse Esther, Vrancken Alexander F. J. E., Eftimov Filip, Notermans Nicolette C., van der Kooi Anneke J., Merkies Ingemar S. J., Jacobs Bart C., van Doorn Pieter A. Maintenance IV immunoglobulin treatment in chronic inflammatory demyelinating polyradiculoneuropathy Journal of the peripheral nervous system 2017;22 (4):425-432 [PubMed]
  • Voortman Mareye, Fritz Daan, Vogels Oscar J. M., Eftimov Filip, van de Beek Diederik, Brouwer Matthijs C., Drent Marjolein Small fiber neuropathy: a disabling and underrecognized syndrome Current opinion in pulmonary medicine 2017;23 (5):447-457 [PubMed]

2016

  • Adrichem Max E., Eftimov Filip, van Schaik Ivo N. Intravenous immunoglobulin treatment in chronic inflammatory demyelinating polyradiculoneuropathy, a time to start and a time to stop Journal of the peripheral nervous system 2016;21 (3):121-127 [PubMed]
  • Leonhard Sonja E., Fritz Daan, Eftimov Filip, van der Kooi Anneke J., van de Beek Diederik, Brouwer Matthijs C. Neurosarcoidosis in a Tertiary Referral Center: A Cross-Sectional Cohort Study Medicine 2016;95 (14):e3277 [PubMed]

2015

  • Eftimov Filip Treatment of chronic inflammatory neuropathies 2015. 221p. ISBN 9789789462957. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van Schaik I. N.)

2014

  • Eftimov Filip, Liesdek Marinus H., Verhamme Camillus, van Schaik Ivo N. Deterioration after corticosteroids in CIDP may be associated with pure focal demyelination pattern BMC neurology 2014;14 (1):72 [PubMed]

2013

  • Eftimov Filip, van Schaik Ivo Chronic inflammatory demyelinating polyradiculoneuropathy: update on clinical features, phenotypes and treatment options Current opinion in neurology 2013;26 (5):496-502 [PubMed]
  • Eftimov Filip, Winer John B., Vermeulen Marinus, de Haan Rob, van Schaik Ivo N. Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy Cochrane database of systematic reviews (Online) 2013;2013 (12):CD001797 [PubMed]

2012

  • Eftimov F., Vermeulen M., van Doorn P. A., Brusse E., van Schaik I. N., van den Berg L. H., van der Pol W. L., Faber C. G., Oostrom J. C. H., Vogels O. J. M., Kleine B. U., van Norden A. G. W., Verschuuren J. J. G. M., Hadden R. D. M. Long-term remission of CIDP after pulsed dexamethasone or short-term prednisolone treatment Neurology 2012;78 (14):1079-1084 [PubMed]

2011

  • Eftimov Filip, van Schaik Ivo N. Immunotherapy of multifocal motor neuropathy Expert opinion on biological therapy 2011;11 (3):329-342 [PubMed]

2010

  • van Schaik Ivo N., Eftimov Filip, van Doorn Pieter A., Brusse Esther, van den Berg Leonard H., van der Pol W. Ludo, Faber Catharina G., van Oostrom Joost Ch, Vogels Oscar Jm, Hadden Rob Dm, Kleine Bert U., van Norden Anouk Gw, Verschuuren Jan Jgm, Dijkgraaf Marcel Gw, Vermeulen Marinus Pulsed high-dose dexamethasone versus standard prednisolone treatment for chronic inflammatory demyelinating polyradiculoneuropathy (PREDICT study): a double-blind, randomised, controlled trial Lancet neurology 2010;9 (3):245-253 [PubMed]

2009

  • van Thiel Pieter-Paul A. M., de Bie Rob M. A., Eftimov Filip, Tepaske Robert, Zaaijer Hans L., van Doornum Gerard J. J., Schutten Martin, Osterhaus Albert D. M. E., Majoie Charles B. L. M., Aronica Eleonora, Fehlner-Gardiner Christine, Wandeler Alex I., Kager Piet A. Fatal human rabies due to Duvenhage virus from a bat in Kenya: failure of treatment with coma-induction, ketamine, and antiviral drugs PLoS neglected tropical diseases 2009;3 (7):e428 [PubMed]
  • Eftimov Filip, Winer John B., Vermeulen Marinus, de Haan Rob, van Schaik Ivo N. Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy Cochrane database of systematic reviews (Online) 2009;2009 (1):CD001797 [PubMed]
  • Eftimov Filip, Vermeulen Marinus, de Haan Rob J., van den Berg Leonard H., van Schaik Ivo N. Subcutaneous immunoglobulin therapy for multifocal motor neuropathy Journal of the peripheral nervous system 2009;14 (2):93-100 [PubMed]

2008

  • van Thiel P. P. A. M., van den Hoek J. A. R., Eftimov F., Tepaske R., Zaaijer H. J., Spanjaard L., de Boer H. E. L., van Doornum G. J. J., Schutten M., Osterhaus A., Kager P. A. Fatal case of human rabies (Duvenhage virus) from a bat in Kenya: The Netherlands, December 2007 Euro surveillance 2008;13 (2):8007 [PubMed]
  • Eftimov F., van Schaik I. N. Immunotherapy of chronic inflammatory demyelinating polyradiculoneuropathy Expert opinion on biological therapy 2008;8 (5):643-655 [PubMed]
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