MD PhD J. Fraessdorf publications


Publications MD PhD J. Fraessdorf

Medical Specialist
Main activities
Patient care, Other
Emergency care, MedEvac, cardiac anesthesiology, Hyperbaric medicine, loco-regional anesthesia,
Focus of research

myocardial protection, preconditioning, postconditioning, mechanisms of anesthetic induced tissue protection


  • Fraessdorf Jan, Hollmann Markus W., Hanschmann Iris, Heinen André, Weber Nina C., Preckel Benedikt, Huhn Ragnar Role of Endogenous Opioid System in Ischemic-Induced Late Preconditioning PLoS ONE 2015;10 (7):e0134283 [PubMed]


  • Schober Patrick, Fräβdorf Jan, Ponsen Kees J., Loer Stephan A., Schwarte Lothar A. A motorcyclist with a dome-shaped deformation of his flank Emergency medicine journal 2012;29 (6):522 [PubMed]
  • Frässdorf Jan Anesthetic induced cardioprotection: from bench to bedside and retour 2012. 318p. ISBN 9789088914928. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Hollmann M. W., Schlack W. S.; Co-supervisors: Hauck N. C., Preckel B.)
  • Preckel B., Eberl S., Fräßdorf J., Hollmann M. W. Management von Patienten mit pulmonaler Hypertonie Anaesthesist 2012;61 (7):574-77, 580-7 [PubMed]


  • Borowski Andreas, Kurt Muhammed, Calvo Sanchez, Paprotny Gerrit, Godehardt Erhard, Fraessdorf Jan, Ghodsizad Ali Metabolic monitoring of postischemic myocardium during intermittent warm-blood cardioplegic administration Texas Heart Institute journal / from the Texas Heart Institute of St. Luke s Episcopal Hospital, Texas Children s Hospital 2010;37 (2):184-188 [PubMed]
  • Fräßdorf Jan, Huhn Ragnar, Niersmann Corinna, Weber Nina C., Schlack Wolfgang, Preckel Benedikt, Hollmann Markus W. Morphine induces preconditioning via activation of mitochondrial K(Ca) channels La morphine provoque le préconditionnement par l'activation des canaux mitochondriaux K(Ca) Canadian journal of anaesthesia = Journal canadien d'anesthésie 2010;57 (8):767-773 [PubMed]
  • Fräßdorf Jan, Huhn Ragnar, Weber Nina C., Ebel Dirk, Wingert Nadja, Preckel Benedikt, Toma Octavian, Schlack Wolfgang, Hollmann Markus W. Sevoflurane-induced Preconditioning Impact of Protocol and Aprotinin Administration on Infarct Size and Endothelial Nitric-Oxide Synthase Phosphorylation in the Rat Heart In Vivo Anesthesiology 2010;113 (6):1289-1298 [PubMed]


  • Fräßdorf J., de Hert S., Schlack W. Anaesthesia and myocardial ischaemia/reperfusion injury British journal of anaesthesia 2009;103 (1):89-98 [PubMed]
  • Wegener Jessica T., Frässdorf Jan, Stevens Markus F. Effective plexus anaesthesia in a patient with Ehlers-Danlos syndrome type III European journal of anaesthesiology 2009;26 (7):619-621 [PubMed]
  • Frässdorf Jan, Borowski Andreas, Ebel Dirk, Feindt Peter, Hermes Manuel, Meemann Thomas, Weber René, Müllenheim Jost, Weber Nina C., Preckel Benedikt, Schlack Wolfgang Impact of preconditioning protocol on anesthetic-induced cardioprotection in patients having coronary artery bypass surgery Journal of thoracic and cardiovascular surgery 2009;137 (6):1436-42, 1442.e1-2 [PubMed]
  • Ebel D., Toma O., Appler S., Baumann K., Fräßdorf J., Preckel B., Rösen P., Schlack W., Weber N. C. Ischemic Preconditioning Phosphorylates Mitogen-activated Kinases and Heat Shock Protein 27 in the Diabetic Rat Heart Hormone and metabolic research. Hormon- und Stoffwechselforschung. Hormones et metabolisme 2009;41 (1):10-15 [PubMed]


  • Weber Nina C., Kandler Jennis, Schlack Wolfgang, Grueber Yvonne, Frädorf Jan, Preckel Benedikt Intermitted pharmacologic pretreatment by xenon, isoflurane, nitrous oxide, and the opioid morphine prevents tumor necrosis factor alpha-induced adhesion molecule expression in human umbilical vein endothelial cells Anesthesiology 2008;108 (2):199-207 [PubMed]
  • Heinen André, Huhn Ragnar, Hollmann Markus W., Preckel Benedikt, Zuurbier Coert J., Schlack Wolfgang, Frässdorf Jan, Weber Nina C. Physiological levels of glutamine prevent morphine-induced preconditioning in the isolated rat heart European journal of pharmacology 2008;595 (1-3):58-64 [PubMed]
  • Heinen André, Winning Adrian, Schlack Wolfgang, Hollmann Markus W., Preckel Benedikt, Frässdorf Jan, Weber Nina C. The regulation of mitochondrial respiration by opening of mKCa channels is age-dependent European journal of pharmacology 2008;578 (2-3):108-113 [PubMed]
  • Weber Nina C., Fräβdorf Jan, Ratajczak Christoph, Grueber Yvonne, Schlack Wolfgang, Hollmann Markus W., Preckel Benedikt Xenon Induces Late Cardiac Preconditioning In Vivo: A Role for Cyclooxygenase 2? Anesthesia and analgesia 2008;107 (6):1807-1813 [PubMed]


  • Frässdorf Jan, Luther Bernd, Müllenheim Jost, Otto Florian, Preckel Benedikt, Schlack Wolfgang, Thämer Volker Influence of groin incision, duration of ischemia, and prostaglandin E1 on ischemia-reperfusion injury of the lower limb Journal of cardiothoracic and vascular anesthesia 2006;20 (2):187-195 [PubMed]


  • Weber Nina C., Toma Octavian, Awan Saqib, Frässdorf Jan, Preckel Benedikt, Schlack Wolfgang Effects of nitrous oxide on the rat heart in vivo: another inhalational anesthetic that preconditions the heart? Anesthesiology 2005;103 (6):1174-1182 [PubMed]
  • Frässdorf Jan, Weber Nina C., Obal Detlef, Toma Octavian, Müllenheim Jost, Kojda Georg, Preckel Benedikt, Schlack Wolfgang Morphine induces late cardioprotection in rat hearts in vivo: the involvement of opioid receptors and nuclear transcription factor kappaB Anesthesia and analgesia 2005;101 (4):934-41, table of contents [PubMed]


  • Ebel Dirk, Müllenheim Jost, Frässdorf Jan, Heinen Andre, Huhn Ragnar, Bohlen Thomas, Ferrari Jan, Südkamp Hendrik, Preckel Benedikt, Schlack Wolfgang, Thämer Volker Effect of acute hyperglycaemia and diabetes mellitus with and without short-term insulin treatment on myocardial ischaemic late preconditioning in the rabbit heart in vivo Pflugers Archiv 2003;446 (2):175-182 [PubMed]
  • Müllenheim Jost, Ebel Dirk, Bauer Mirco, Otto Florian, Heinen André, Frässdorf Jan, Preckel Benedikt, Schlack Wolfgang Sevoflurane confers additional cardioprotection after ischemic late preconditioning in rabbits Anesthesiology 2003;99 (3):624-631 [PubMed]


  • Müllenheim Jost, Ebel Dirk, Frässdorf Jan, Preckel Benedikt, Thämer Volker, Schlack Wolfgang Isoflurane preconditions myocardium against infarction via release of free radicals Anesthesiology 2002;96 (4):934-940 [PubMed]
  • Preckel Benedikt, Ebel Dirk, Müllenheim Jost, Frässdorf Jan, Thämer Volker, Schlack Wolfgang The direct myocardial effects of xenon in the dog heart in vivo Anesthesia and analgesia 2002;94 (3):545-51; table of contents [PubMed]


  • Müllenheim J., Schlack W., Frässdorf J., Heinen A., Preckel B., Thämer V. Additive protective effects of late and early ischaemic preconditioning are mediated by the opening of KATP channels in vivo Pflugers Archiv 2001;442 (2):178-187 [PubMed]
  • Müllenheim J., Frässdorf J., Preckel B., Thämer V., Schlack W. Ketamine, but not S(+)-ketamine, blocks ischemic preconditioning in rabbit hearts in vivo Anesthesiology 2001;94 (4):630-636 [PubMed]
  • Müllenheim J., Rulands R., Wietschorke T., Frässdorf J., Preckel B., Schlack W. Late preconditioning is blocked by racemic ketamine, but not by S(+)-ketamine Anesthesia and analgesia 2001;93 (2):265-70, 1st contents page [PubMed]
  • Ebel D., Lipfert P., Frässdorf J., Preckel B., Müllenheim J., Thämer V., Schlack W. Lidocaine reduces ischaemic but not reperfusion injury in isolated rat heart British journal of anaesthesia 2001;86 (6):846-852 [PubMed]