M.A. Middelkamp Hup MD PhD publications

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Publications MD PhD M.A. Middelkamp Hup

Positions
Other Academic Staff, Medical Specialist
Main activities
Education, Patient care, Research
Specialisation
Dermatology; focus on Pediatric Dermatology, Atopic Dermatitis and Allergic Contact Dermatitis
Focus of research

Atopic Dermatitis (AD)

 

-AD in children: fillagrin mutations, skin barrier biomarkers and immunological biomarkers, related to clinical parameters and phenotype

 

-The role of allergic contact dermatitis in children with and without AD

 

-Fillagrin mutations and clinical outcome of AD

 

-Immunology: T cells subsets, with emphasis on IL-31 producing T cells; Cytokine profiles in transdermal fluid

 

Haemangiomas

 

- treatment of ulcerated hemangiomas

 

 

 

2021

  • Bosma Angela Leigh-Ann, Ouwerkerk Wouter, Middelkamp-Hup Maritza Albertina Children with atopic eczema experiencing increased disease severity in the pollen season more often have hay fever at a young age and a dark skin type Journal of dermatology 2021 [PubMed]

2020

  • Bosma A. L., Hyseni A. M., Gerbens L. A. A., Middelkamp Hup M. A., Spuls P. I. Bewijs uit registratiestudies voor atopisch eczeem Nederlands tijdschrift voor dermatologie en venereologie 2020;30 (8):26-29
  • Lommerts J. E. Annelies, Chandeck C., Middelkamp Hup M. A., Kemperman P. M. H. J. Bloed, zweet en tranen Nederlands tijdschrift voor dermatologie en venereologie 2020;30 (8):34-36
  • de Wijs L. E. M., Bosma A. L., Erler N. S., Hollestein L. M., Gerbens L. A. A., Middelkamp-Hup M. A., Kunkeler A. C. M., Nijsten T. E. C., Spuls P. I., Hijnen D. J. Effectiveness of dupilumab treatment in 95 patients with atopic dermatitis: daily practice data British journal of dermatology 2020;182 (2):418-426 [PubMed]
  • Roekevisch E., Szegedi K., Hack D. P., Schram M. E., Res P. C. J. M., Bos J. D., Leeflang M. M. G., Luiten R. M., Kezic S., Spuls P. I., Middelkamp-Hup M. A. Effect of immunosuppressive treatment on biomarkers in adult atopic dermatitis patients Journal of the European Academy of Dermatology and Venereology 2020;34 (7):1545-1554 [PubMed]
  • Bosma Angela L., de Wijs Linde E. M., Hof Michel H., van Nieuwenhuizen Beau R., Gerbens Louise A. A., Middelkamp-Hup Maritza A., Hijnen DirkJan, Spuls Phyllis I. Long-term effectiveness and safety of treatment with dupilumab in patients with atopic dermatitis: Results of the TREAT NL (TREatment of ATopic eczema, the Netherlands) registry Journal of the American Academy of Dermatology 2020;83 (5):1375-1384 [PubMed]
  • Bosma A. L., Spuls P. I., Garcia-Doval I., Naldi L., Prieto-Merino D., Tesch F., Apfelbacher C. J., Arents B. W. M., Barbarot S., Baselga E., Deleuran M., Eichenfield L. F., Gerbens L. A. A., Irvine A. D., Manca A., Mendes-Bastos P., Middelkamp-Hup M. A., Roberts A., Seneschal J., Thyssen J. P., Torres T., Vermeulen F. M., Vestergaard C., von Kobyletzki L. B., Wall D., Weidinger S., Schmitt J., Flohr C. TREatment of ATopic eczema (TREAT) Registry Taskforce: protocol for a European safety study of dupilumab and other systemic therapies in patients with atopic eczema British journal of dermatology 2020;182 (6):1423-1429 [PubMed]

2019

  • Hulshof L., Hack D. P., Hasnoe Q. C. J., Dontje B., Jakasa I., Riethmüller C., McLean W. H. I., van Aalderen W. M. C., van't Land B., Kezic S., Sprikkelman A. B., Middelkamp-Hup M. A. A minimally invasive tool to study immune response and skin barrier in children with atopic dermatitis British journal of dermatology 2019;180 (3):621-630 [PubMed]
  • Vermeulen F. M., Gerbens L. A.A., Bosma A. L., Apfelbacher C. J., Irvine A. D., Arents B. W.M., Barbarot S., Deleuran M., Eichenfield L. F., Manca A., Schmitt J., Vestergaard C., Wall D., Weidinger S., Middelkamp-Hup M. A., Spuls P. I., Flohr C. TREatment of ATopic eczema (TREAT) Registry Taskforce: consensus on how and when to measure the core dataset for atopic eczema treatment research registries British journal of dermatology 2019;181 (3):492-504 [PubMed]
  • Gerbens L. A. A., Apfelbacher C. J., Irvine A. D., Barbarot S., de Booij R. J., Boyce A. E., Deleuran M., Eichenfield L. F., Hof M. H., Middelkamp-Hup M. A., Roberts A., Schmitt J., Vestergaard C., Wall D., Weidinger S., Williamson P. R., Flohr C., Spuls P. I. TREatment of ATopic eczema (TREAT) Registry Taskforce: an international Delphi exercise to identify a core set of domains and domain items for national atopic eczema photo- and systemic therapy registries British journal of dermatology 2019;180 (4):790-801 [PubMed]

2018

  • Boonstra M., Rustemeyer T., Middelkamp-Hup M. A. Both children and adult patients with difficult-to-treat atopic dermatitis have high prevalences of concomitant allergic contact dermatitis and are frequently polysensitized Journal of the European Academy of Dermatology and Venereology 2018;32 (9):1554-1561 [PubMed]
  • Hulshof Lies, Overbeek Saskia A., Wyllie Anne L., Chu Mei Ling J. N., Bogaert Debby, de Jager Wilco, Knippels Leon M. J., Sanders Elisabeth A. M., van Aalderen Wim M. C., Garssen Johan, van't Land Belinda, Sprikkelman Aline B., Blauw A., Dontje B., Duijvestein Y. C. M., de Boom W. H. C., Groot I., Boks M., van Kooyk Y., Fandri D. H. H., Hijnen D., Middelkamp-Hup M. A., Papi B., Roelofs M., Rijnierse A., Veening D., Prakken B. J., ten Tusscher G. W., Tupker R. A., Willemsen L. E. M. Exploring immune development in infants with moderate to severe atopic dermatitis Frontiers in immunology 2018;9 (MAR) [PubMed]
  • Szegedi Krisztina, van Lier Amanda, Res Pieter C., Chielie Saskia, Bos Jan D., Kezic Sanja, Middelkamp-Hup Maritza A., Luiten Rosalie M. House Dust Mite allergens Der f and Der p induce IL-31 production by blood derived T cells from Atopic Dermatitis patients Experimental dermatology 2018;27 (4):393-395 [PubMed]
  • Middelkamp Hup M. A. Infecties van de neonaat Nederlands tijdschrift voor dermatologie en venereologie 2018;28 (3):38-39
  • Teligui Leylah, Arents B. W. M., Galimont A. F. S., Geleedst-de Vooght M. M. M., van Lümig P. P. M., Rustemeyer T., de Bruin-Weller M. S., Middelkamp Hup M. A. Samenvatting Leidraad Dermatocorticosteroïden Nederlands tijdschrift voor dermatologie en venereologie 2018;28 (7):9-13
  • Roekevisch Evelien Systemic Treatment in Atopic Dermatitis 2018. 209p. ISBN 9789402812862. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Spuls Phyllis I.; Co-supervisors: Middelkamp Hup M. A. , Leeflang Mariska M. G.)

2017

  • Lubbes Stefanie, Rustemeyer Thomas, Sillevis Smitt Johannes H., Schuttelaar Marie Louise, Middelkamp-Hup Maritza A. Contact sensitization in Dutch children and adolescents with and without atopic dermatitis - a retrospective analysis Contact dermatitis 2017;76 (3):151-159 [PubMed]
  • van der Rhee E. A., Middelkamp-Hup M. A., Hoekzema R. Een baby met toenemende huidafwijkingen op de scalp Nederlands tijdschrift voor geneeskunde 2017;161:D1198 [PubMed]
  • Roekevisch E., Leeflang M. M. G., Schram M. E., Campbell L. E., Irwin McLean W. H., Kezic S., Bos J. D., Spuls P. I., Middelkamp-Hup M. A. Patients with atopic dermatitis with filaggrin loss-of-function mutations show good but lower responses to immunosuppressive treatment British journal of dermatology 2017;177 (6):1745-1746 [PubMed]
  • Spuls Phyllis I., Gerbens Louise A. A., Apfelbacher Christian J., Wall Dmitri, Arents Bernd W. M., Barbarot Sebastien, Roberts Amanda, Deleuran Mette, Middelkamp-Hup Maritza A., Vestergaard Christian, Weidinger Stephan, Schmitt Jochen, Irvine Alan D., Flohr Carsten The International TREatment of ATopic Eczema (TREAT) Registry Taskforce: An Initiative to Harmonize Data Collection across National Atopic Eczema Photo- and Systemic Therapy Registries Journal of investigative dermatology 2017;137 (9):2014-2016 [PubMed]
  • Gerbens Louise A. A., Boyce Aaron E., Wall Dmitri, Barbarot Sebastien, de Booij Richard J., Deleuran Mette, Middelkamp-Hup Maritza A., Roberts Amanda, Vestergaard Christian, Weidinger Stephan, Apfelbacher Christian J., Irvine Alan D., Schmitt Jochen, Williamson Paula R., Spuls Phyllis I., Flohr Carsten TREatment of ATopic eczema (TREAT) Registry Taskforce: protocol for an international Delphi exercise to identify a core set of domains and domain items for national atopic eczema registries Trials 2017;18 (1):87 [PubMed]

2016

  • Sillevis Smitt J. H., Middelkamp Hup M. A., van der Horst C. M. A. M., Reekers J. A., Koelemay M. J. W. Classificatie van vaatlaesies, de ISSVA-classificatie. Nederlands tijdschrift voor dermatologie en venereologie 2016;26 (5):302-307
  • Middelkamp Hup M. A., van der Horst C. M. A. M., Sillevis Smitt J. H. Een rapidly involuting congenital hemangioma (RICH) met ulceratie: een atypische presentatie. Nederlands tijdschrift voor dermatologie en venereologie 2016;26 (5):311-314
  • van Ratingen A. R., Middelkamp Hup M. A., van der Linden M. M. D. Moeilijke rosacea. Nederlands tijdschrift voor dermatologie en venereologie 2016;26 (5):293-296
  • van der Horst C. M. A. M., Sillevis Smitt J. H., Peters M. A. D., Middelkamp Hup M. A., van den Berg L., Wösten-van Asperen R. M., Kindermann A., Merks J. H. M. Multifocale lymphangio-endotheliomatose met trombocytopenie (MLE-T): vroegtijdige herkenning is van levensbelang. Nederlands tijdschrift voor dermatologie en venereologie 2016;26 (5):314-317
  • Geerdink J., van der Horst C. M. A. M., Middelkamp Hup M. A. PHACE-syndroom. Nederlands tijdschrift voor dermatologie en venereologie 2016;26 (5):307-311

2015

  • Szegedi K., Lutter R., Res P. C., Bos J. D., Luiten R. M., Kezic S., Middelkamp-Hup M. A. Cytokine profiles in interstitial fluid from chronic atopic dermatitis skin Journal of the European Academy of Dermatology and Venereology 2015;29 (11):2136-2144 [PubMed]

2014

  • Kezic Sanja, Novak Natalija, Jakasa Ivone, Jungersted Jackob M., Simon Michel, Brandner Johanna M., Middelkamp-Hup Maritza A., Weidinger Stephan Skin barrier in atopic dermatitis FRONTIERS IN BIOSCIENCE-LANDMARK 2014;19:542-556 [PubMed]

2013

  • Proudfoot L. E., Powell A. M., Ayis S., Barbarot S., Baselga Torres E., Deleuran M., Fölster-Holst R., Gelmetti C., Hernández-Martin A., Middelkamp-Hup M. A., Oranje A. P., Logan K., Perkins M., Patrizi A., Rovatti G., Schofield O., Spuls P., Svensson A., Vestergaard C., Wahlgren C.-F., Schmitt J., Flohr C. The European treatment of severe atopic eczema in children taskforce (TREAT) survey British journal of dermatology 2013;169 (4):901-909 [PubMed]

2012

  • Szegedi Krisztina, Kremer Andreas E., Kezic Sanja, Teunissen Marcel B. M., Bos Jan D., Luiten Rosalie M., Res Pieter C., Middelkamp-Hup Maritza A. Increased frequencies of IL-31-producing T cells are found in chronic atopic dermatitis skin Experimental dermatology 2012;21 (6):431-436 [PubMed]

2010

  • Bos Jan D., Brenninkmeijer Elian E. A., Schram Mandy E., Middelkamp-Hup Maritza A., Spuls Phyllis I., Smitt J. Henk Sillevis Atopic eczema or atopiform dermatitis Experimental dermatology 2010;19 (4):325-331 [PubMed]

2009

  • Galvis-Martinez J. C., Sillevis Smitt J. H., Middelkamp-Hup M. A. Bilaterale acromiale kuiltjes Nederlands tijdschrift voor dermatologie en venereologie 2009;19 (6):313-315
  • Appelman M., Starink M. V., Middelkamp-Hup M. A. Granulaire celtumor Nederlands tijdschrift voor dermatologie en venereologie 2009;19 (6):310-312

2008

  • Middelkamp-Hup Maritza A., Bos Jan D., González Salvador, Westerhof Wiete Regulation and modulation of skin melanogenesis Expert review of dermatology 2008;3 (2):176-186

2007

  • Middelkamp-Hup M. A. Detection, modulation and impact of skin pigmention 2007. 192p. ISBN 9789090215204. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Bos Jan D.; Co-supervisors: Westerhof W., Gonzalez S.)
  • Middelkamp-Hup M. A., Bos J. D., Rius-Diaz F., Gonzalez S., Westerhof W. Treatment of vitiligo vulgaris with narrow-band UVB and oral Polypodium leucotomos extract: a randomized double-blind placebo-controlled study Journal of the European Academy of Dermatology and Venereology 2007;21 (7):942-950 [PubMed]

2006

  • Middelkamp-Hup Maritza A., Park H.-Y., Lee Jin, Gilchrest Barbara A., Gonzalez Salvador Detection of UV-induced pigmentary and epidermal changes over time using in vivo reflectance confocal microscopy Journal of investigative dermatology 2006;126 (2):402-407 [PubMed]

2004

  • Middelkamp-Hup M. A., Scheurer C. D., Goedkoop A. Y., Sillevis Smitt J. H. Onbegrepen hyperpigmentatie van de lippen Nederlands tijdschrift voor dermatologie en venereologie 2004;14 (6):185-186
  • Middelkamp-Hup Maritza A., Pathak Madhu A., Parrado Concepcion, Garcia-Caballero Tomas, Rius-Díaz Francisca, Fitzpatrick Thomas B., González Salvador Orally administered Polypodium leucotomos extract decreases psoralen-UVA-induced phototoxicity, pigmentation, and damage of human skin Journal of the American Academy of Dermatology 2004;50 (1):41-49 [PubMed]
  • Middelkamp-Hup Maritza A., Pathak Madhu A., Parrado Concepcion, Goukassian David, Rius-Díaz Francisca, Mihm Martín C., Fitzpatrick Thomas B., González Salvador Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin Journal of the American Academy of Dermatology 2004;51 (6):910-918 [PubMed]
  • Park Hee-Young, Lee Jin, González Salvador, Middelkamp-Hup Maritza A., Kapasi Sameer, Peterson Shaun, Gilchrest Barbara A. Topical application of a protein kinase C inhibitor reduces skin and hair pigmentation Journal of investigative dermatology 2004;122 (1):159-166 [PubMed]

2003

  • Hicks Shari P., Swindells Kirsty J., Middelkamp-Hup Maritza A., Sifakis Martine A., González Ernesto, González Salvador Confocal histopathology of irritant contact dermatitis in vivo and the impact of skin color (black vs white) Journal of the American Academy of Dermatology 2003;48 (5):727-734 [PubMed]
  • Middelkamp-Hup Maritza A., Sánchez-Carpintero Ignacio, Kossodo Sylvie, Waterman Peter, González Salvador, Mihm Martin C., Anderson R. Rox Photodynamic therapy for cutaneous proliferative vascular tumors in a mouse model Journal of investigative dermatology 2003;121 (3):634-639 [PubMed]

2002

  • Middelkamp Hup M. A., Heide R., Tank B., Mulder P. G. H., Oranje A. P. Comparison of mastocytosis with onset in children and adults Journal of the European Academy of Dermatology and Venereology 2002;16 (2):115-120 [PubMed]

2001

  • Heide R., Middelkamp Hup M. A., Mulder P. G., Oranje A. P. Clinical scoring of cutaneous mastocytosis Acta dermato-venereologica 2001;81 (4):273-276 [PubMed]