M.C. Brouwer MD PhD publications

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Publications MD PhD M.C. Brouwer

Position
Medical Specialist
Main activities
Education, Patient care, Research
Specialisation
Neurological infectious diseases
Focus of research

AMC Department of Neurology

The Department of Neurology performs clinical and translational research within three research themes: infection & inflammation, cerebrovasculair disorders, and movement disorders. The themes are imbedded in the nine translational research programs of Amsterdam Neuroscience, the research institute of neuroscience investigators in the Amsterdam area. All staff members of the Department of Neurology are involved in research and collaborate within Neuroscience Amsterdam, with other academic and non-academic hospitals, and with international research groups.

Infection & Inflammation

We perform clinical translational research in the field of neurological infections & inflammation. We perform prospective clinical cohort studies, randomized clinical trials, and experimental research, combining our clinical expertise with groundbreaking, translational approaches using clinical data, human samples, next generation sequencing, in vitro techniques, and mouse models in the era's of bacterial meningitis & encephalitis, infections after stroke, septic encephalopathy, and inflammatory diseases of peripheral nerves and muscles.

Dr. Brouwer

The focus of Dr. Brouwer’s research is on neurological infectious diseases, including bacterial meningitis, viral meningitis, chronic meningitis and neuroborreliosis. To this aim he has set up a nation-wide genetic association study on community-acquired bacterial meningitis (MeninGene study) and a study on suspected meningitis and encephalitis patients (PACEM study).

During his PhD Dr. Brouwer studied host genetic factors influencing bacterial meningitis in the nationwide cohort study on culture proven bacterial meningitis. By March 2017, 2300 patients have been included in this ongoing study. With this study we showed that adjunctive dexamethasone has successfully been implemented in the Netherlands, leading to a nationwide reduction of mortality and morbidity of bacterial meningitis. Furthermore, we identified common genetic variants in complement component 3 and 5 that influence susceptibility and outcome of bacterial meningitis. In several translational research projects we used clinical and genetic data to study pathofysiology of bacterial meningitis and identify new adjunctive treatments.

 

Amsterdam UMC Research Institutes
AMC departments
All publications

2021

  • Vlaar Alexander P. J., de Bruin Sanne, Brouwer Matthijs C., van de Beek Diederik Efficacy matters: broadening complement inhibition in COVID-19 – Authors' reply The Lancet Rheumatology 2021;3 (2):e95-e96
  • Kloek Anne T., Seron Mercedes Valls, Schmand Ben, Tanck Michael W. T., van der Ende Arie, Brouwer Matthijs C., van de Beek Diederik Individual responsiveness of macrophage migration inhibitory factor predicts long-term cognitive impairment after bacterial meningitis Acta neuropathologica communications 2021;9 (1) [PubMed]

2020

  • Vlaar Alexander P. J., de Bruin Sanne, Busch Matthias, Timmermans Sjoerd A. M. E. G., van Zeggeren Ingeborg E., Koning Rutger, ter Horst Liora, Bulle Esther B., van Baarle Frank E. H. P., van de Poll Marcel C. G., Kemper E. Marleen, van der Horst Iwan C. C., Schultz Marcus J., Horn Janneke, Paulus Frederique, Bos Lieuwe D., Wiersinga W. Joost, Witzenrath Martin, Rueckinger Simon, Pilz Korinna, Brouwer Matthijs C., Guo Ren-Feng, Heunks Leo, van Paassen Pieter, Riedemann Niels C., van de Beek Diederik Anti-C5a antibody IFX-1 (vilobelimab) treatment versus best supportive care for patients with severe COVID-19 (PANAMO): an exploratory, open-label, phase 2 randomised controlled trial The Lancet Rheumatology 2020;2 (12):e764-e773
  • Dorresteijn Kirsten R. I. S., Brouwer Matthijs C., Jellema Korné, van de Beek Diederik Bacterial external ventricular catheter-associated infection Expert review of anti-infective therapy 2020;18 (3):219-229 [PubMed]
  • Kasanmoentalib Erna S. Bacterial meningitis and the complement system 2020. 160p. ISBN 9789464161588. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van de Beek Diederik; Co-supervisor: Brouwer Matthijs C.)
  • Deliran Shahrzad S., Brouwer Matthijs C., Coutinho Jonathan M., Beek Diederik van de Bacterial meningitis complicated by cerebral venous thrombosis European Stroke Journal 2020;5 (4):394-401
  • Dorresteijn Kirsten R. I. S., Verheul Rolf J., Ponjee Gabriëlle A. E., Tewarie Rishi Nandoe, Müller Marcella C. A., van de Beek Diederik, Brouwer Matthijs C., Jellema Korné Cerebrospinal fluid analysis from bilateral external ventricular drains in suspected nosocomial infection Journal of infection 2020;81 (1):147-178 [PubMed]
  • ter Horst Liora, Brouwer Matthijs C., van der Ende Arie, van de Beek Diederik Community-acquired Bacterial Meningitis in Adults With Cerebrospinal Fluid Leakage Clinical infectious diseases 2020;70 (11):2256-2261 [PubMed]
  • van Kassel Merel N., van Haeringen Koen J., Brouwer Matthijs C., Bijlsma Merijn W., van de Beek Diederik Community-acquired group B streptococcal meningitis in adults Journal of infection 2020;80 (3):255-260 [PubMed]
  • Figueiredo A. H. A., Brouwer M. C., Bijlsma M. W., van der Ende A., van de Beek D. Community-acquired pneumonia in patients with bacterial meningitis: a prospective nationwide cohort study Clinical microbiology and infection 2020;26 (4):513.e7-513.e11 [PubMed]
  • Costerus Joost M., Lemmens Cynthia M. C., van de Beek Diederik, Brouwer Matthijs C. Cranial Imaging and Lumbar Puncture in Patients With Suspected Central Nervous System Infection Clinical infectious diseases 2020;70 (12):2469-2475 [PubMed]
  • van Zeggeren I. E., Edridge A. W. D., van de Beek D., Deijs M., Koekkoek S. M., Wolthers K. C., van der Hoek L., Brouwer M. C. Diagnostic accuracy of VIDISCA-NGS in patients with suspected central nervous system infections Clinical microbiology and infection 2020 [PubMed]
  • Haak Bastiaan W., Westendorp Willeke F., van Engelen Tjitske S. R., Brands Xanthe, Brouwer Matthijs C., Vermeij Jan-Dirk, Hugenholtz Floor, Verhoeven Aswin, Derks Rico J., Giera Martin, Nederkoorn Paul J., de Vos Willem M., van de Beek Diederik, Wiersinga W. Joost Disruptions of Anaerobic Gut Bacteria Are Associated with Stroke and Post-stroke Infection: a Prospective Case–Control Study TRANSLATIONAL STROKE RESEARCH 2020 [PubMed]
  • Kremer Philip H. C., Lees John A., Ferwerda Bart, Bijlsma Merijn W., Macalasdair Neil, van der Ende Arie, Brouwer Matthijs C., Bentley Stephen D., van de Beek Diederik Diversification in immunogenicity genes caused by selective pressures in invasive meningococci Microbial genomics 2020;6 (9):1-9 [PubMed]
  • Kloek Anne T. Genetics and outcome of bacterial meningitis 2020. 238p. ISBN 9789464161663. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van de Beek Diederik; Co-supervisor: Brouwer Matthijs C.)
  • Kremer Philip H. C., Lees John A., Ferwerda Bart, van de Ende Arie, Brouwer Matthijs C., Bentley Stephen D., van de Beek Diederik Genetic Variation in Neisseria meningitidis Does Not Influence Disease Severity in Meningococcal Meningitis Frontiers in Medicine 2020;7 [PubMed]
  • Engelen-Lee JooYeon Histopathology of bacterial meningitis: Snapshots of the brain 2020. 218p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van de Beek Diederik; Co-supervisor: Brouwer Matthijs)
  • Rinkel L. A., Prick J. C. M., Slot R. E. R., Sombroek N. M. A., Burggraaff J., Groot A. E., Emmer B. J., Roos Y. B. W. E. M., Brouwer M. C., van den Berg-Vos R. M., Majoie C. B. L. M., Beenen L. F. M., van de Beek D., Visser M. C., van Schaik S. M., Coutinho J. M. Impact of the COVID-19 outbreak on acute stroke care Journal of neurology 2020 [PubMed]
  • Fritz Daan, Timmermans Wilhelmina M. C., van Laar Jan A. M., van Hagen P. Martin, Siepman Theodora A. M., van de Beek Diederik, Brouwer Matthijs C. Infliximab treatment in pathology-confirmed neurosarcoidosis Neurology® neuroimmunology & neuroinflammation 2020;7 (5) [PubMed]
  • Bodilsen Jacob, Dalager-Pedersen Michael, van de Beek Diederik, Brouwer Matthijs C., Nielsen Henrik Long-term mortality and epilepsy in patients after brain abscess: A nationwide population-based matched cohort study Clinical infectious diseases 2020;71 (11):2825-2832 [PubMed]
  • Kloek A. T., Brouwer M. C., Schmand B., Tanck M. W. T., van de Beek D. Long-term neurologic and cognitive outcome and quality of life in adults after pneumococcal meningitis Clinical microbiology and infection 2020;26 (10):1361-1367 [PubMed]
  • Brouwer Matthijs C., Ascione Tiziana, Pagliano Pasquale Neurologic aspects of COVID-19: A concise Review Infezioni in Medicina 2020;28:42-45 [PubMed]
  • Koelman D. L. H., Brouwer M. C., van de Beek D. Resurgence of pneumococcal meningitis in Europe and Northern America Clinical microbiology and infection 2020;26 (2):199-204 [PubMed]
  • Bodilsen Jacob, Dalager-Pedersen Michael, van de Beek Diederik, Brouwer Matthijs C., Nielsen Henrik Risk Factors for Brain Abscess: A Nationwide, Population-Based, Nested Case-Control Study Clinical infectious diseases 2020;71 (4):1040-1046 [PubMed]
  • van Zeggeren Ingeborg E., Bijlsma Merijn W., Tanck Michael W., van de Beek Diederik, Brouwer Matthijs C. Systematic review and validation of diagnostic prediction models in patients suspected of meningitis Journal of infection 2020;80 (2):143-151 [PubMed]
  • Ghijselings I. E., Hoogland I. C. M., Brouwer M. C., van der Voort P. H. J., Horn J. The broad differential diagnosis of encephalitis: A case report Netherlands journal of critical care 2020;28 (2):103-106
  • Dekkers Gillian, Brouwer Mieke C., Jeremiasse Jorn, Kamp Angela, Biggs Robyn M., van Mierlo Gerard, Lauder Scott, Katti Suresh, Kuijpers Taco W., Rispens Theo, Jongerius Ilse Unraveling the Effect of a Potentiating Anti-Factor H Antibody on Atypical Hemolytic Uremic Syndrome-Associated Factor H Variants Journal of immunology (Baltimore, Md. 2020;205 (7):1778-1786 [PubMed]
  • Fritz Daan, van de Beek Diederik, Brouwer Matthijs C., Booij Jan Whole-Body 18F-FDG PET-CT in the Diagnosis of Neurosarcoidosis Mayo Clinic proceedings. Mayo Clinic 2020;95 (5):1082-1084

2019

  • van Kassel Merel N., Bijlsma Merijn W., Brouwer Matthijs C., van der Ende Arie, van de Beek Diederik Community-acquired group B streptococcal meningitis in adults: 33 cases from prospective cohort studies Journal of infection 2019;78 (1):54-57 [PubMed]
  • van Dijk Bart J., Meijers Joost C. M., Kloek Anne T., Knaup Veronique L., Rinkel Gabriel J. E., Morgan B. Paul, van der Kamp Marije J., Osuka Koji, Aronica Eleonora, Ruigrok Ynte M., van de Beek Diederik, Brouwer Matthijs, Pekna Marcela, Hol Elly M., Vergouwen Mervyn D. I. Complement C5 Contributes to Brain Injury After Subarachnoid Hemorrhage TRANSLATIONAL STROKE RESEARCH 2019 [PubMed]
  • Kasanmoentalib E. Soemirien, Valls Serón Mercedes, Engelen-Lee Joo Yeon, Tanck Michael W., Pouw Richard B., van Mierlo Gerard, Wouters Diana, Pickering Matthew C., van der Ende Arie, Kuijpers Taco W., Brouwer Matthijs C., van de Beek Diederik Complement factor H contributes to mortality in humans and mice with bacterial meningitis Journal of neuroinflammation 2019;16 (1) [PubMed]
  • Costerus Joost M., Brouwer Matthijs C., Sprengers Marieke E.S., Roosendaal Stefan D., Van Der Ende Arie, Van De Beek Diederik CT-hersenen, lumbaalpunctie en klinische achteruitgang bij bacteriële meningitis: Een landelijk cohortonderzoek Nederlands tijdschrift voor geneeskunde 2019;163 (8) [PubMed]
  • Dorresteijn Kirsten R. I. S., Jellema Korné, van de Beek Diederik, Brouwer Matthijs C. Factors and measures predicting external CSF drain-associated ventriculitis: A review and meta-analysis Neurology 2019;93 (22):964-972 [PubMed]
  • Kloek Anne T., Brouwer Matthijs C., van de Beek Diederik Host genetic variability and pneumococcal disease: a systematic review and meta-analysis BMC medical genomics 2019;12 (1):130 [PubMed]
  • Bodilsen J., Dalager-Pedersen M., van de Beek D., Brouwer M. C., Nielsen H. Incidence and mortality of brain abscess in Denmark: a nationwide population-based study Clinical microbiology and infection 2019;26 (1):95-100 [PubMed]
  • Lees John A., Ferwerda Bart, Kremer Philip H. C., Wheeler Nicole E., Serón Mercedes Valls, Croucher Nicholas J., Gladstone Rebecca A., Bootsma Hester J., Rots Nynke Y., Wijmega-Monsuur Alienke J., Sanders Elisabeth A. M., Trzciński Krzysztof, Wyllie Anne L., Zwinderman Aeilko H., van den Berg Leonard H., van Rheenen Wouter, Veldink Jan H., Harboe Zitta B., Lundbo Lene F., de Groot Lisette C. P. G. M., van Schoor Natasja M., van der Velde Nathalie, Ängquist Lars H., Sørensen Thorkild I. A., Nohr Ellen A., Mentzer Alexander J., Mills Tara C., Knight Julian C., du Plessis Mignon, Nzenze Susan, Weiser Jeffrey N., Parkhill Julian, Madhi Shabir, Benfield Thomas, von Gottberg Anne, van der Ende Arie, Brouwer Matthijs C., Barrett Jeffrey C., Bentley Stephen D., van de Beek Diederik Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis Nature communications 2019;10 (1) [PubMed]
  • van de Beek Diederik, Brouwer Matthijs C. Reply to McDowell and Chapman Clinical infectious diseases 2019;69 (7):1267-1268 [PubMed]
  • Ferwerda Bart, Maury Mylène M., Brouwer Mathijs C., Hafner Lukas, van der Ende Arie, Bentley Stephen, Lecuit Marc, van de Beek Diederik Residual Variation Intolerance Score Detects Loci Under Selection in Neuroinvasive Listeria monocytogenes Frontiers in microbiology 2019;10 [PubMed]
  • Dias Sara P., Brouwer Matthijs C., van de Beek Diederik Sex-based differences in the response to dexamethasone in bacterial meningitis: Analysis of the European dexamethasone in adulthood bacterial meningitis study British journal of clinical pharmacology 2019 [PubMed]
  • Koelman Diederik L. H., Brouwer Matthijs C., van de Beek Diederik Targeting the complement system in bacterial meningitis Brain 2019;142 (11):3325-3337 [PubMed]
  • van Ettekoven Cornelis N., Brouwer Matthijs C., Bijlsma Merijn W., Wijdicks Eelco F. M., van de Beek Diederik The FOUR score as predictor of outcome in adults with bacterial meningitis Neurology 2019;92 (22):e2522-e2526 [PubMed]
  • Tattevin Pierre, Solomon Tom, Brouwer Matthijs C. Understanding central nervous system efficacy of antimicrobials Intensive care medicine 2019;45 (1):93-96 [PubMed]
  • Edridge Arthur W. D., Deijs Martin, van Zeggeren Ingeborg E., Kinsella Cormac M., Jebbink Maarten F., Bakker Margreet, van de Beek Diederik, Brouwer Matthijs C., van der Hoek Lia Viral metagenomics on cerebrospinal fluid Genes 2019;10 (5) [PubMed]

2018

  • Figueiredo Ana Helena A., Brouwer Matthijs C., van de Beek Diederik Acute Community-Acquired Bacterial Meningitis Neurologic Clinics 2018;36 (4):809-820 [PubMed]
  • Bodilsen Jacob, Brouwer Matthijs C., Nielsen Henrik, van de Beek Diederik Anti-infective treatment of brain abscess Expert review of anti-infective therapy 2018;16 (7):565-578 [PubMed]
  • van de Beek Diederik, Brouwer Matthijs C. Atraumatic lumbar puncture needles: practice needs to change Lancet 2018;391 (10126):1128-1129 [PubMed]
  • van Veen Kiril E. B. Bacterial meningitis in immunocompromised patients 2018. ISBN 9789463323291. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van de Beek D.; Co-supervisor: Brouwer M. C.)
  • Koopmans Merel M., Engelen-Lee JooYeon, Brouwer Matthijs C., Jaspers Valery, Man Wing Kit, Vall Seron Mercedes, van de Beek Diederik Characterization of a Listeria monocytogenes meningitis mouse model Journal of neuroinflammation 2018;15 (1) [PubMed]
  • Wieske Luuk, Beuers Ulrich, Brouwer Matthijs C. Clinical Reasoning: Accumulating endocrinopathies in a car salesman Neurology 2018;90 (19):E1720-E1723 [PubMed]
  • Bodilsen Jacob, Brouwer Matthijs C., Kjærgaard Nicolai, Sirks Marc J., van der Ende Arie, Nielsen Henrik, van de Beek Diederik Community-acquired meningitis in adults caused by Escherichia coli in Denmark and The Netherlands Journal of infection 2018;77 (1):25-29 [PubMed]
  • van Beek Anna E., Sarr Isatou, Correa Simon, Nwakanma Davis, Brouwer Mieke C., Wouters Diana, Secka Fatou, Anderson Suzanne T. B., Conway David J., Walther Michael, Levin Michael, Kuijpers Taco W., Cunnington Aubrey J. Complement Factor H levels associate with Plasmodium falciparum malaria susceptibility and severity Open forum infectious diseases 2018;5 (7) [PubMed]
  • Pouw Richard B., Brouwer Mieke C., van Beek Anna E., Józsi Mihály, Wouters Diana, Kuijpers Taco W. Complement factor H-related protein 4A is the dominant circulating splice variant of CFHR4 Frontiers in immunology 2018;9 (APR) [PubMed]
  • Costerus Joost M., Brouwer Matthijs C., Sprengers Marieke E. S., Roosendaal Stefan D., van der Ende Arie, van de Beek Diederik Cranial Computed Tomography, Lumbar Puncture, and Clinical Deterioration in Bacterial Meningitis: A Nationwide Cohort Study Clinical infectious diseases 2018;67 (6):920-926 [PubMed]
  • Engelen-Lee Joo-Yeon, Brouwer Matthijs C., Aronica Eleonora, van de Beek Diederik Delayed cerebral thrombosis complicating pneumococcal meningitis: an autopsy study Annals of intensive care 2018;8 (1):20 [PubMed]
  • Brouwer Matthijs C., van de Beek Diederik Epidemiology of community-acquired bacterial meningitis Current opinion in infectious diseases 2018;31 (1):78-84 [PubMed]
  • Engelen-Lee Joo-Yeon, Koopmans Merel M., Brouwer Matthijs C., Aronica Eleonora, van de Beek Diederik Histopathology of Listeria meningitis Journal of neuropathology and experimental neurology 2018;77 (10):950-957 [PubMed]
  • Costerus Joost M. Lumbar puncture in bacterial meningitis 2018. ISBN 9789463750073. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van de Beek D.; Co-supervisor: Brouwer M. C.)
  • Bodilsen Jacob, Dalager-Pedersen Michael, Kjærgaard Nicolai, van de Beek Diederik, Brouwer Matthijs C., Nielsen Henrik Positive predictive value of icd-10 diagnosis codes for brain abscess in the danish national patient registry Clinical epidemiology 2018;10:1503-1508 [PubMed]
  • van der Spek Anne H., Surovtseva Olga V., Jim Kin Ki, van Oudenaren Adri, Brouwer Matthijs C., Vandenbroucke-Grauls Christina M. J. E., Leenen Pieter J. M., van de Beek Diederik, Hernandez Arturo, Fliers Eric, Boelen Anita Regulation of intracellular triiodothyronine is essential for optimal macrophage function Endocrinology 2018;159 (5):2241-2252 [PubMed]
  • Costerus Joost M., Brouwer Matthijs C., van de Beek Diederik Technological advances and changing indications for lumbar puncture in neurological disorders Lancet neurology 2018;17 (3):268-278 [PubMed]
  • van der Spek Anne H., Jim Kin Ki, Karaczyn Aldona, van Beeren Hermina C., Ackermans Mariëtte T., Darras Veerle M., Vandenbroucke-Grauls Christina M. J. E., Hernandez Arturo, Brouwer Matthijs C., Fliers Eric, van de Beek Diederik, Boelen Anita The Thyroid Hormone Inactivating Type 3 Deiodinase Is Essential for Optimal Neutrophil Function: Observations From Three Species Endocrinology 2018;159 (2):826-835 [PubMed]
  • Kloek A. T., Khan H. N., Valls Seron M., Jongejan A., Zwinderman A. H., Baas F., van der Ende A., van de Beek D., Ferwerda B., Brouwer M. C. Variation in coagulation and fibrinolysis genes evaluated for their contribution to cerebrovascular complications in adults with bacterial meningitis in the Netherlands Journal of infection 2018;77 (1):54-59 [PubMed]
  • Brouwer Matthijs C., van de Beek Diederik Viral meningitis in the UK: time to speed up Lancet infectious diseases 2018;18 (9):930-931

2017

  • van de Beek Diederik, Brouwer Matthijs C. 2016, the year of Zika virus Nature reviews. Neurology 2017;13 (2):69-70 [PubMed]
  • Khatib Ula, van de Beek Diederik, Lees John A., Brouwer Matthijs C. Adults with suspected central nervous system infection: A prospective study of diagnostic accuracy Journal of infection 2017;74 (1):1-9 [PubMed]
  • van Veen Kiril E. B., Brouwer Matthijs C., van der Ende Arie, van de Beek Diederik Bacterial meningitis in alcoholic patients: A population-based prospective study Journal of infection 2017;74 (4):352-357 [PubMed]
  • van Veen Kiril E. B., Brouwer Matthijs C., van der Ende Arie, van de Beek Diederik Bacterial Meningitis in Patients using Immunosuppressive Medication: a Population-based Prospective Nationwide Study Journal of neuroimmune pharmacology 2017;12 (2):213-218 [PubMed]
  • Kremer Philip H. C., Lees John A., Koopmans Merel M., Ferwerda Bart, Arends Agaath W. M., Feller Monique M., Schipper Kim, Valls Seron Mercedes, van der Ende Arie, Brouwer Matthijs C., van de Beek Diederik, Bentley Stephen D. Benzalkonium tolerance genes and outcome in Listeria monocytogenes meningitis Clinical microbiology and infection 2017;23 (4):265E1-265E7 [PubMed]
  • Costerus Joost M., Brouwer Matthijs C., Bijlsma Merijn W., van de Beek Diederik Community-acquired bacterial meningitis Current opinion in infectious diseases 2017;30 (1):135-141 [PubMed]
  • Brouwer Matthijs C., van de Beek Diederik Epidemiology, diagnosis, and treatment of brain abscesses Current opinion in infectious diseases 2017;30 (1):129-134 [PubMed]
  • Zonneveld Thomas P., Nederkoorn Paul J., Westendorp Willeke F., Brouwer Matthijs C., van de Beek Diederik, Kruyt Nyika D., Vermeij J.-D., Zock E., Hooijenga I. J., Kerkhoff H., Kleyweg R. P., Kwa V. I. H., Bosboom J. L. W., Weisfelt M., Remmers M. J. M., van Dijk E. J., Vermeij F. H., Schreuder A. H. C. M. L., Vermeer S. E., ten Houten R., Dippel D. W. J., Kappelle L. J., van der Worp H. B., Merkies I. S. J., de Bruijn S. F. T. M., de Laat K. F., Jellema K., Keizer K., de Rijk M. C., Vermeij A. J., Visser M. C., Aerden L. A. M., Schut E. S., Reichman L. J. A., de Gans K., van den Berg-Vos R. M., van Goor M. P. J., Wijnhoud A. D., van der Ree T. C., Janmaat M., van Orshoven N. P., Manschot S. M. Hyperglycemia predicts poststroke infections in acute ischemic stroke Neurology 2017;88 (15):1415-1421 [PubMed]
  • Lees John A., Kremer Philip H. C., Manso Ana S., Croucher Nicholas J., Ferwerda Bart, Valls Serón Mercedes, Oggioni Marco R., Parkhill Julian, Brouwer Matthijs C., van der Ende Arie, van de Beek Diederik, Bentley Stephen D. Large scale genomic analysis shows no evidence for pathogen adaptation between the blood and cerebrospinal fluid niches during bacterial meningitis Microbial genomics 2017;3 (1):e000103 [PubMed]
  • Koopmans Merel M., Bijlsma Merijn W., Brouwer Matthijs C., van de Beek Diederik, van der Ende Arie Listeria monocytogenes meningitis in the Netherlands, 1985-2014: A nationwide surveillance study Journal of infection 2017;75 (1):12-19 [PubMed]
  • Brouwer M. C., van de Beek D. Management of bacterial central nervous system infections Handbook of clinical neurology / edited by P.J. Vinken and G.W. Bruyn 2017;140:349-364 [PubMed]
  • Kasanmoentalib E. Soemirien, Valls Seron Mercedes, Ferwerda Bart, Tanck Michael W., Zwinderman Aeilko H., Baas Frank, van der Ende Arie, Brouwer Matthijs C., van de Beek Diederik Mannose-binding lectin-associated serine protease 2 (MASP-2) contributes to poor disease outcome in humans and mice with pneumococcal meningitis Journal of neuroinflammation 2017;14 (1):2 [PubMed]
  • Kasanmoentalib E. Soemirien, Valls Seron Mercedes, Ferwerda Bart, Tanck Michael W., Zwinderman Aeilko H., Baas Frank, van der Ende Arie, Schwaeble William J., Brouwer Matthijs C., van de Beek Diederik Mannose-binding lectin-associated serine protease 2 (MASP-2) contributes to poor disease outcome in humans and mice with pneumococcal meningitis (vol 14, pg 9, 2017) Journal of neuroinflammation 2017;14 (1):77 [PubMed]
  • Fritz Daan, Voortman Mareye, van de Beek Diederik, Drent Marjolein, Brouwer Matthijs C. Many faces of neurosarcoidosis: from chronic meningitis to myelopathy Current opinion in pulmonary medicine 2017;23 (5):439-446 [PubMed]
  • Brouwer Matthijs C., van de Beek Diederik MONALISA: a grim picture of listeriosis Lancet infectious diseases 2017;17 (5):464-466 [PubMed]
  • Pannekoek Yvonne, Huis In 't Veld Robert A. G., Schipper Kim, Bovenkerk Sandra, Kramer Gertjan, Brouwer Matthijs C., van de Beek Diederik, Speijer Dave, van der Ende Arie Neisseria meningitidis Uses Sibling Small Regulatory RNAs To Switch from Cataplerotic to Anaplerotic Metabolism mBio 2017;8 (2):e02293-16 [PubMed]
  • van de Beek Diederik, Brouwer Matthijs C. Neurological infections in 2016: Zika and the rest Lancet neurology 2017;16 (1):17-18 [PubMed]
  • Iovino Federico, Engelen-Lee Joo-Yeon, Brouwer Matthijs, van de Beek Diederik, van der Ende Arie, Valls Seron Merche, Mellroth Peter, Muschiol Sandra, Bergstrand Jan, Widengren Jerker, Henriques-Normark Birgitta pIgR and PECAM-1 bind to pneumococcal adhesins RrgA and PspC mediating bacterial brain invasion Journal of experimental medicine 2017;214 (6):1619-1630 [PubMed]
  • Dias S. P., Brouwer M. C., Bijlsma M. W., van der Ende A., van de Beek D. Sex-based differences in adults with community-acquired bacterial meningitis: a prospective cohort study Clinical microbiology and infection 2017;23 (2):121.e9-121.e15 [PubMed]
  • Voortman Mareye, Fritz Daan, Vogels Oscar J. M., Eftimov Filip, van de Beek Diederik, Brouwer Matthijs C., Drent Marjolein Small fiber neuropathy: a disabling and underrecognized syndrome Current opinion in pulmonary medicine 2017;23 (5):447-457 [PubMed]
  • van Ettekoven C. N., van de Beek D., Brouwer M. C. Update on community-acquired bacterial meningitis: guidance and challenges Clinical microbiology and infection 2017;23 (9):601-606 [PubMed]
  • Lees John A., Brouwer Matthijs, van der Ende Arie, Parkhill Julian, van de Beek Diederik, Bentley Stephen D. Within-Host Sampling of a Natural Population Shows Signs of Selection on Pde1 during Bacterial Meningitis Infection and immunity 2017;85 (3):UNSP e01061-16 [PubMed]

2016

  • Bijlsma Merijn W. Bacterial meningitis: epidemiology, herd protection, clinical characteristics, and risk assessment 2016. 173p. ISBN 9789462993655. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van de Beek D.; Co-supervisors: van der Ende A., Brouwer M. C.)
  • van Veen Kiril E. B., Brouwer Matthijs C., van der Ende Arie, van de Beek Diederik Bacterial meningitis in diabetes patients: a population-based prospective study Scientific reports 2016;6:36996 [PubMed]
  • van Veen K. E. B., Brouwer M. C., van der Ende A., van de Beek D. Bacterial meningitis in hematopoietic stem cell transplant recipients: a population-based prospective study Bone marrow transplantation 2016;51 (11):1490-1495 [PubMed]
  • van Veen Kiril E. B., Brouwer Matthijs C., van der Ende Arie, van de Beek Diederik Bacterial meningitis in patients with HIV: A population-based prospective study Journal of infection 2016;72 (3):362-368 [PubMed]
  • van Veen K. E. B., Brouwer M. C., van der Ende A., van de Beek D. Bacterial meningitis in solid organ transplant recipients: a population-based prospective study Transplant infectious disease 2016;18 (5):674-680 [PubMed]
  • van Samkar Anusha, Brouwer Matthijs C., van der Ende Arie, van de Beek Diederik Campylobacter Fetus Meningitis in Adults: Report of 2 Cases and Review of the Literature Medicine 2016;95 (8):e2858 [PubMed]
  • van Samkar A., Brouwer M. C., Schultsz C., van der Ende A., van de Beek D. Capnocytophaga canimorsus Meningitis: Three Cases and a Review of the Literature Zoonoses and public health 2016;63 (6):442-448 [PubMed]
  • Fritz Daan, van de Beek Diederik, Brouwer Matthijs C. Clinical features, treatment and outcome in neurosarcoidosis: systematic review and meta-analysis BMC neurology 2016;16 (1):220 [PubMed]
  • Pagliano Pasquale, Brouwer Matthijs C. Comment: "Implementation of a Meningitis Care Bundle in the Emergency Room Reduces Mortality Associated With Acute Bacterial Meningitis" Annals of pharmacotherapy 2016;50 (2):152 [PubMed]
  • van de Beek Diederik, Brouwer Matthijs, Hasbun Rodrigo, Koedel Uwe, Whitney Cynthia G., Wijdicks Eelco Community-acquired bacterial meningitis Nature reviews. Disease primers 2016;2:16074 [PubMed]
  • Bijlsma Merijn W., Brouwer Matthijs C., Kasanmoentalib E. Soemirien, Kloek Anne T., Lucas Marjolein J., Tanck Michael W., van der Ende Arie, van de Beek Diederik Community-acquired bacterial meningitis in adults in the Netherlands, 2006-14: a prospective cohort study Lancet infectious diseases 2016;16 (3):339-347 [PubMed]
  • Costerus Joost M., Brouwer Matthijs C., van der Ende Arie, van de Beek Diederik Community-acquired bacterial meningitis in adults with cancer or a history of cancer Neurology 2016;86 (9):860-866 [PubMed]
  • Lucas Marjolein J. Complications and outcome of bacterial meningitis 2016. 159p. ISBN 9789463320245. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van de Beek D.; Co-supervisor: Brouwer M. C.)
  • Leonhard Sonja E., Fritz Daan, van de Beek Diederik, Brouwer Matthijs C. Cryptococcal meningitis complicating sarcoidosis Medicine 2016;95 (35):e4587 [PubMed]
  • Duitman Janwillem, Valls Serón Mercedes, Engelen-Lee Jooyeon, Brouwer Matthijs C., Spek C. Arnold, van de Beek Diederik Detrimental role for CCAAT/enhancer binding protein δ in blood-borne brain infection BMC infectious diseases 2016;16 (1):670 [PubMed]
  • van de Beek D., Cabellos C., Dzupova O., Esposito S., Klein M., Kloek A. T., Leib S. L., Mourvillier B., Ostergaard C., Pagliano P., Pfister H. W., Read R. C., Sipahi O. Resat, Brouwer M. C. ESCMID guideline: diagnosis and treatment of acute bacterial meningitis Clinical microbiology and infection 2016;22 (Suppl. 3):S37-S62 [PubMed]
  • Kloek Anne T., van Setten Jessica, van der Ende Arie, Bots Michiel L., Asselbergs Folkert W., Valls Serón Mercedes, Brouwer Matthijs C., van de Beek Diederik, Ferwerda Bart Exome Array Analysis of Susceptibility to Pneumococcal Meningitis Scientific reports 2016;6:29351 [PubMed]
  • Savva Athina, Brouwer Matthijs C., Roger Thierry, Valls Serón Mercedes, le Roy Didier, Ferwerda Bart, van der Ende Arie, Bochud Pierre-Yves, van de Beek Diederik, Calandra Thierry Functional polymorphisms of macrophage migration inhibitory factor as predictors of morbidity and mortality of pneumococcal meningitis Proceedings of the National Academy of Sciences of the United States of America 2016;113 (13):3597-3602 [PubMed]
  • Costerus J. M., Brouwer M. C., Bijlsma M. W., Tanck M. W., van der Ende A., van de Beek D. Impact of an evidence-based guideline on the management of community-acquired bacterial meningitis: a prospective cohort study Clinical microbiology and infection 2016;22 (11):928-933 [PubMed]
  • Jim Kin Ki, Engelen-Lee Jooyeon, van der Sar Astrid M., Bitter Wilbert, Brouwer Matthijs C., van der Ende Arie, Veening Jan-Willem, van de Beek Diederik, Vandenbroucke-Grauls Christina M. J. E. Infection of zebrafish embryos with live fluorescent Streptococcus pneumoniae as a real-time pneumococcal meningitis model Journal of neuroinflammation 2016;13 (1):188 [PubMed]
  • Brouwer M. C., van de Beek D. , de Gans Jan Meningitis, bacterialin: Stella R. Quah, William C. Cockerham, editors. International Encyclopedia of Public Health, 2nd edition San Diego. Academic Press; 2016. p. 21-25, ISBN 9780128036785
  • Lucas Marjolein J., Brouwer Matthijs C., van de Beek Diederik Neurological sequelae of bacterial meningitis Journal of infection 2016;73 (1):18-27 [PubMed]
  • Leonhard Sonja E., Fritz Daan, Eftimov Filip, van der Kooi Anneke J., van de Beek Diederik, Brouwer Matthijs C. Neurosarcoidosis in a Tertiary Referral Center: A Cross-Sectional Cohort Study Medicine 2016;95 (14):e3277 [PubMed]
  • Geldhoff Madelijn Pathophysiology of pneumococcal meningitis 2016. 215p. ISBN 9789463320627. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van de Beek D., van der Poll T.; Co-supervisor: Brouwer M. C.)
  • Engelen-Lee Joo-Yeon, Brouwer Matthijs C., Aronica Eleonora, van de Beek Diederik Pneumococcal meningitis: Clinical-pathological correlations (meningene-path) Acta neuropathologica communications 2016;4 (1):26 [PubMed]
  • Westendorp Willeke F., Vermeij Jan-Dirk, Brouwer Matthijs C., Roos Y. B. W. E. M., Nederkoorn Paul J., van de Beek Diederik Pre-Stroke Use of Beta-Blockers Does Not Lower Post-Stroke Infection Rate: An Exploratory Analysis of the Preventive Antibiotics in Stroke Study Cerebrovascular diseases (Basel, Switzerland) 2016;42 (5-6):506-511 [PubMed]
  • Vermeij Jan-Dirk, Westendorp Willeke F., Roos Yvo B., Brouwer Matthijs C., van de Beek Diederik, Nederkoorn Paul J. Preventive Ceftriaxone in Patients with Stroke Treated with Intravenous Thrombolysis: Post Hoc Analysis of the Preventive Antibiotics in Stroke Study Cerebrovascular diseases (Basel, Switzerland) 2016;42 (5-6):361-369 [PubMed]
  • Costerus J. M., Brouwer M. C., van der Ende A., van de Beek D. Repeat lumbar puncture in adults with bacterial meningitis Clinical microbiology and infection 2016;22 (5):428-433 [PubMed]
  • Bijlsma Merijn W., Brouwer Matthijs C., Bossuyt Patrick M., Heymans Martijn W., van der Ende Arie, Tanck Michael W. T., van de Beek Diederik Risk scores for outcome in bacterial meningitis: Systematic review and external validation study Journal of infection 2016;73 (5):393-401 [PubMed]
  • Dias Sara P., Brouwer Matthijs C., Bijlsma Merijn W., van der Ende Arie, van de Beek Diederik Sex-based differences in pneumococcal serotype distribution in adults with pneumococcal meningitis Journal of infection 2016;73 (6):616-619 [PubMed]
  • van Samkar A., Brouwer M. C., van der Ende A., van de Beek D. Streptococcus equi meningitis Clinical microbiology and infection 2016;22 (1):e3-e4 [PubMed]
  • Cotlarciuc Ioana, Marjot Thomas, Khan Muhammad S., Hiltunen Sini, Haapaniemi Elena, Metso Tiina M., Putaala Jukka, Zuurbier Susanna M., Brouwer Matthijs C., Passamonti Serena M., Bucciarelli Paolo, Pappalardo Emanuela, Patel Tasmin, Costa Paolo, Colombi Marina, Canhão Patrícia, Tkach Aleksander, Santacroce Rosa, Margaglione Maurizio, Favuzzi Giovanni, Grandone Elvira, Colaizzo Donatella, Spengos Kostas, Arauz Antonio, Hodge Amanda, Ditta Reina, Debette Stephanie, Zedde Marialuisa, Pare Guillaume, Ferro José M., Thijs Vincent, Pezzini Alessandro, Majersik Jennifer J., Martinelli Ida, Coutinho Jonathan M., Tatlisumak Turgut, Sharma Pankaj Towards the genetic basis of cerebral venous thrombosis-the BEAST Consortium: a study protocol BMJ open 2016;6 (11):e012351 [PubMed]
  • Valls Serón Mercedes, Ferwerda Bart, Engelen-Lee Jooyeon, Geldhoff Madelijn, Jaspers Valery, Zwinderman Aeilko H., Tanck Michael W., Baas Frank, van der Ende Arie, Brouwer Matthijs C., van de Beek Diederik V-akt murine thymoma viral oncogene homolog 3 (AKT3) contributes to poor disease outcome in humans and mice with pneumococcal meningitis Acta neuropathologica communications 2016;4 (1):50 [PubMed]
  • Ferwerda Bart, Valls Serón Mercedes, Jongejan Aldo, Zwinderman Aeilko H., Geldhoff Madelijn, van der Ende Arie, Baas Frank, Brouwer Matthijs C., van de Beek Diederik Variation of 46 Innate Immune Genes Evaluated for their Contribution in Pneumococcal Meningitis Susceptibility and Outcome EBioMedicine 2016;10:77-84 [PubMed]
  • Brouwer Matthijs C., Wijdicks Eelco F. M., van de Beek Diederik What's new in bacterial meningitis Intensive care medicine 2016;42 (3):415-417 [PubMed]
  • van Samkar Anusha Zoonotic bacterial meningitis in adults: clinical characteristics, etiology, treatment and outcome 2016. 151p. ISBN 9789463320689. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van de Beek D.; Co-supervisors: Brouwer M. C., van der Ende A.)
  • van Samkar Anusha, Brouwer Matthijs C., van der Ende Arie, van de Beek Diederik Zoonotic bacterial meningitis in human adults Neurology 2016;87 (11):1171-1179 [PubMed]

2015

  • Kasanmoentalib E. Soemirien, Valls Seron Mercedes, Morgan B. Paul, Brouwer Matthijs C., van de Beek Diederik Adjuvant treatment with dexamethasone plus anti-C5 antibodies improves outcome of experimental pneumococcal meningitis: a randomized controlled trial Journal of neuroinflammation 2015;12 (1):149 [PubMed]
  • Valls Serón Mercedes, Duitman Janwillem, Geldhoff Madelijn, Engelen-Lee Jooyeon, Havik Stefan R., Brouwer Matthijs C., van de Beek Diederik, Spek C. Arnold CCAAT/enhancer-binding protein δ (C/EBPδ) aggravates inflammation and bacterial dissemination during pneumococcal meningitis Journal of neuroinflammation 2015;12 (1):88 [PubMed]
  • Brouwer Matthijs C., McIntyre Peter, Prasad Kameshwar, van de Beek Diederik Corticosteroids for acute bacterial meningitis Cochrane database of systematic reviews (Online) 2015;2015 (9):CD004405 [PubMed]
  • Brouwer Matthijs C., van de Beek Diederik Earlier Treatment and Improved Outcome in Adult Bacterial Meningitis Following Guideline Revision Promoting Prompt Lumbar Puncture Clinical infectious diseases 2015;61 (4):664-665 [PubMed]
  • Lucas Marjolein J., Brouwer Matthijs C., Bovenkerk Sandra, Man Wing Kit, van der Ende Arie, van de Beek Diederik Group A Streptococcal meningitis in adults Journal of infection 2015;71 (1):37-42 [PubMed]
  • van de Beek Diederik, Brouwer Matthijs, Nederkoorn Paul Parenteral antibiotics are not enough to prevent pneumonia in stroke - Authors' reply Lancet 2015;386 (9994):653-654 [PubMed]
  • Adriani Kirsten Saskia Risk factors for community-acquired bacterial meningitis in adults 2015. 136p. ISBN 9789490791377. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van de Beek D.; Co-supervisor: Brouwer M. C.)
  • Adriani K. S., Brouwer M. C., van de Beek D. Risk factors for community-acquired bacterial meningitis in adults Netherlands journal of medicine 2015;73 (2):53-60 [PubMed]
  • van Samkar A., Brouwer M. C., Pannekoek Y., van der Ende A., van de Beek D. Streptococcus gallolyticus meningitis in adults: report of five cases and review of the literature Clinical microbiology and infection 2015;21 (12):1077-1083 [PubMed]
  • van Samkar Anusha, Brouwer Matthijs C., Schultsz Constance, van der Ende Arie, van de Beek Diederik Streptococcus suis Meningitis: A Systematic Review and Meta-analysis PLoS neglected tropical diseases 2015;9 (10):e0004191 [PubMed]
  • van Samkar Anusha, Brouwer Matthijs C., Schultsz Constance, van der Ende Arie, van de Beek Diederik Streptococcus suis meningitis in the Netherlands Journal of infection 2015;71 (5):602-604 [PubMed]
  • van Samkar A., van de Beek D., Stijnis C., Goris M., Brouwer M. C. Suspected leptospiral meningitis in adults: report of four cases and review of the literature Netherlands journal of medicine 2015;73 (10):464-470 [PubMed]
  • Westendorp Willeke F., Vermeij Jan-Dirk, Zock Elles, Hooijenga Imke J., Kruyt Nyika D., Bosboom Hans J. L. W., Kwa Vincent I. H., Weisfelt Martijn, Remmers Michel J. M., ten Houten Robert, Schreuder A. H. C. M. Tobien, Vermeer Sarah E., van Dijk Ewout J., Dippel Diederik W. J., Dijkgraaf Marcel G. W., Spanjaard Lodewijk, Vermeulen Marinus, van der Poll Tom, Prins Jan M., Vermeij Frederique H., Roos Yvo B. W. E. M., Kleyweg Ruud P., Kerkhoff Henk, Brouwer Matthijs C., Zwinderman Aeilko H., van de Beek Diederik, Nederkoorn Paul J., Vermeij J.-D., Kerkhoff H., Bosboom J. L. W., Kwa V. I. H., Weisfelt M., Remmers M. J. M., van Dijk E. J., Vermeij F., Schreuder A., Vermeer S. E., ten Houten R., Dippel D. W. J., Kappelle L. J., van der Worp H. B., Merkies I. S. J., de Bruijn S. F. T. M., de Laat K. F., Haag Den, Jellema K., Keizer K., de Rijk M. C., Vermeij A. J., de Gans K. The Preventive Antibiotics in Stroke Study (PASS): a pragmatic randomised open-label masked endpoint clinical trial Lancet 2015;385 (9977):1519-1526 [PubMed]
  • Mook-Kanamori B. B., Valls Serón M., Geldhoff M., Havik S. R., van der Ende A., Baas F., van der Poll T., Meijers J. C. M., P Morgan B., Brouwer M. C., van de Beek D. Thrombin-activatable fibrinolysis inhibitor influences disease severity in humans and mice with pneumococcal meningitis Journal of thrombosis and haemostasis 2015;13 (11):2076-2086 [PubMed]
  • Coumou J., Herkes E. A., Brouwer M. C., van de Beek D., Tas S. W., Casteelen G., van Vugt M., Starink M. V., de Vries H. J. C., de Wever B., Spanjaard L., Hovius J. W. R. Ticking the right boxes: classification of patients suspected of Lyme borreliosis at an academic referral center in the Netherlands Clinical microbiology and infection 2015;21 (4):368.e11-368.e20 [PubMed]
  • Mook Barry Brendon Translational studies in pneumococcal meningitis 2015. 188p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van de Beek D.; Co-supervisor: Brouwer M. C.)

2014

  • Bijlsma Merijn W., Brouwer Matthijs C., Spanjaard Lodewijk, van de Beek Diederik, van der Ende Arie A decade of herd protection after introduction of meningococcal serogroup C conjugate vaccination Clinical infectious diseases 2014;59 (9):1216-1221 [PubMed]
  • Heckenberg Sebastiaan G. B., Brouwer Matthijs C., van de Beek Diederik Bacterial meningitis Handbook of clinical neurology / edited by P.J. Vinken and G.W. Bruyn 2014;121:1361-1375 [PubMed]
  • Brouwer M. C., van de Beek Diederik Bacterial Meningitisin: J. Farrar, J. Hotez, T. Junghans, G. Kang, D. Lallo, N. White, editors. Manson's tropical diseases. S.l.: Elsevier; 2014. p. 361-369, ISBN 9780702051012
  • Brouwer Matthijs C., Tunkel Allan R., van de Beek Diederik Brain abscess New England journal of medicine 2014;371 (18):1758 [PubMed]
  • Brouwer Matthijs C., Tunkel Allan R., McKhann Guy M., van de Beek Diederik Brain Abscess New England journal of medicine 2014;371 (5):447-456 [PubMed]
  • Mook-Kanamori Barry B., Brouwer Matthijs C., Geldhoff Madelijn, Ende Arie van der, van de Beek Diederik Cerebrospinal fluid complement activation in patients with pneumococcal and meningococcal meningitis Journal of infection 2014;68 (6):542-547 [PubMed]
  • Koopmans Merel M., Brouwer Matthijs C., Geldhoff Madelijn, Seron Mercedes Valls, Houben Judith, van der Ende Arie, van de Beek Diederik Cerebrospinal fluid inflammatory markers in patients with Listeria monocytogenes meningitis BBA clinical 2014;1:44-51 [PubMed]
  • Brouwer Matthijs C., Coutinho Jonathan M., van de Beek Diederik Clinical characteristics and outcome of brain abscess Systematic review and meta-analysis Neurology 2014;82 (9):806-813 [PubMed]
  • Bijlsma Merijn W., Bekker Vincent, Brouwer Matthijs C., Spanjaard Lodewijk, van de Beek Diederik, van der Ende Arie Epidemiology of invasive meningococcal disease in the Netherlands, 1960-2012: an analysis of national surveillance data Lancet infectious diseases 2014;14 (9):805-812 [PubMed]
  • van 't Hof Femke N. G., Kurki Mitja I., Kleinloog Rachel, de Bakker Paul I. W., von Und Zu Fraunberg Mikael, Jääskeläinen Juha E., Gaál Emília I., Lehto Hanna, Kivisaari Riku, Laakso Aki, Niemelä Mika, Hernesniemi Juha, Brouwer Matthijs C., van de Beek Diederik, Rinkel Gabriël J. E., Ruigrok Ynte M. Genetic risk load according to the site of intracranial aneurysms Neurology 2014;83 (1):34-39 [PubMed]
  • Klein Matthias, Brouwer Matthijs C., Angele Barbara, Geldhoff Madelijn, Marquez Gabriel, Varona Rosa, Häcker Georg, Schmetzer Helga, Häcker Hans, Hammerschmidt Sven, van der Ende Arie, Pfister Hans-Walter, van de Beek Diederik, Koedel Uwe Leukocyte attraction by CCL20 and its receptor CCR6 in humans and mice with pneumococcal meningitis PLoS ONE 2014;9 (4):e93057 [PubMed]
  • Bijlsma Merijn W., Brouwer Matthijs C., van den Kerkhof Hans, Knol Mirjam J., van de Beek Diederik, van der Ende Arie No evidence of clusters of serogroup C meningococcal disease in the Dutch MSM community Journal of infection 2014;68 (3):296-297 [PubMed]
  • Lucas Marjolein J., Brouwer Matthijs C., van der Ende Arie, van de Beek Diederik Outcome in patients with bacterial meningitis presenting with a minimal Glasgow Coma Scale score Neurology® neuroimmunology & neuroinflammation 2014;1 (1):e9 [PubMed]
  • Brouwer Matthijs C., Meijers Joost C. M., Baas Frank, van der Ende Arie, Pfister Hans-Walter, Giese Armin, van de Beek Diederik, Koedel Uwe Plasminogen activator inhibitor-1 influences cerebrovascular complications and death in pneumococcal meningitis Acta neuropathologica 2014;127 (4):553-564 [PubMed]
  • Piet Jurgen R., Geldhoff Madelijn, van Schaik Barbera D. C., Brouwer Matthijs C., Valls Seron Mercedes, Jakobs Marja E., Schipper Kim, Pannekoek Yvonne, Zwinderman Aeilko H., van der Poll Tom, van Kampen Antoine H. C., Baas Frank, van der Ende Arie, van de Beek Diederik Streptococcus pneumoniae arginine synthesis genes promote growth and virulence in pneumococcal meningitis Journal of infectious diseases 2014;209 (11):1781-1791 [PubMed]
  • Westendorp Willeke F., Vermeij Jan-Dirk, Dippel Diederik W. J., Dijkgraaf Marcel G. W., van der Poll Tom, Prins Jan M., Vermeij Frederique H., Roos Yvo B. W. E. M., Brouwer Matthijs C., Zwinderman Aeilko H., van de Beek Diederik, Nederkoorn Paul J. Update of the Preventive Antibiotics in Stroke Study (PASS): statistical analysis plan Trials 2014;15 (1):382 [PubMed]

2013

  • Hovius Joppe W. R., de Wever Bob, Sohne Maaike, Brouwer Matthijs C., Coumou Jeroen, Wagemakers Alex, Oei Anneke, Knol Henrike, Narasimhan Sukanya, Hodiamont Caspar J., Jahfari Setareh, Pals Steven T., Horlings Hugo M., Fikrig Erol, Sprong Hein, van Oers Marinus H. J. A case of meningoencephalitis by the relapsing fever spirochaete Borrelia miyamotoi in Europe Lancet 2013;382 (9892):658 [PubMed]
  • Boelman Cyrus G., Brouwer Matthijs C., van de Beek Diederik Adjunctive dexamethasone in adults with meningococcal meningitis Neurology 2013;80 (19):1818-1819 [PubMed]
  • Adriani Kirsten S., Brouwer Matthijs C., van der Ende Arie, van de Beek Diederik Bacterial Meningitis in Adults After Splenectomy and Hyposplenic States Mayo Clinic proceedings. Mayo Clinic 2013;88 (6):571-578 [PubMed]
  • Adriani Kirsten S., Brouwer Matthijs C., Geldhoff Madelijn, Baas Frank, Zwinderman Aeilko H., Paul Morgan B., Harris Claire L., van der Ende Arie, van de Beek Diederik Common polymorphisms in the complement system and susceptiblity to bacterial meningitis Journal of infection 2013;66 (3):255-262 [PubMed]
  • Brouwer Matthijs C., McIntyre Peter, Prasad Kameshwar, van de Beek Diederik Corticosteroids for acute bacterial meningitis Cochrane database of systematic reviews (Online) 2013;2013 (6):CD004405 [PubMed]
  • Lucas Marjolein J., Brouwer Matthijs C., van de Beek Diederik Delayed cerebral thrombosis in bacterial meningitis: a prospective cohort study Intensive care medicine 2013;39 (5):866-871 [PubMed]
  • Lucas Marjolein J., Brouwer Matthijs C., van der Ende Arie, van de Beek Diederik Endocarditis in adults with bacterial meningitis Circulation 2013;127 (20):2056-2062 [PubMed]
  • Brouwer Matthijs C., Baas Frank, van der Ende Arie, van de Beek Diederik Genetic variation and cerebrospinal fluid levels of mannose binding lectin in pneumococcal meningitis patients PLoS ONE 2013;8 (5):e65151 [PubMed]
  • Geldhoff Madelijn, Mook-Kanamori Barry B., Brouwer Matthijs C., Valls Seron Mercedes, Baas Frank, van der Ende Arie, van de Beek Diederik Genetic variation in inflammasome genes is associated with outcome in bacterial meningitis Immunogenetics 2013;65 (1):9-16 [PubMed]
  • Geldhoff Madelijn, Mook-Kanamori Barry B., Brouwer Matthijs C., Troost Dirk, Leemans Jaklien C., Flavell Richard A., van der Ende Arie, van der Poll Tom, van de Beek Diederik Inflammasome activation mediates inflammation and outcome in humans and mice with pneumococcal meningitis BMC infectious diseases 2013;13 (1):358 [PubMed]
  • Brouwer Matthijs C., van de Beek Diederik Intensified intravenous rifampicin in tuberculous meningitis Lancet infectious diseases 2013;13 (1):2-3 [PubMed]
  • Koopmans Merel M., Brouwer Matthijs C., Bijlsma Merijn W., Bovenkerk Sandra, Keijzers Wendy, van der Ende Arie, van de Beek Diederik Listeria monocytogenes sequence type 6 and increased rate of unfavorable outcome in meningitis: epidemiologic cohort study Clinical infectious diseases 2013;57 (2):247-253 [PubMed]
  • Brouwer Matthijs C., Jim Kin K., Benschop Kimberley S., Wolthers Katja C., van der Ende Arie, de Jong Menno D., van de Beek Diederik No evidence of viral coinfection in cerebrospinal fluid from patients with community-acquired bacterial meningitis Journal of infectious diseases 2013;208 (1):182-184 [PubMed]
  • Bijlsma Merijn W., Brouwer Matthijs C., van de Beek Diederik Prognostic risk score for pleocytosis with a negative gram stain: valid but of limited utility in bacterial meningitis patients Mayo Clinic proceedings. Mayo Clinic 2013;88 (4):421 [PubMed]
  • Hasbun Rodrigo, Bijlsma Merijn, Brouwer Matthijs C., Khoury Nabil, Hadi Christiane M., van der Ende Arie, Wootton Susan H., Salazar Lucrecia, Hossain Md Monir, Beilke Mark, van de Beek Diederik Risk score for identifying adults with CSF pleocytosis and negative CSF Gram stain at low risk for an urgent treatable cause Journal of infection 2013;67 (2):102-110 [PubMed]
  • Iovino Federico, Brouwer Matthijs C., van de Beek Diederik, Molema Grietje, Bijlsma Jetta J. E. Signalling or binding: the role of the platelet-activating factor receptor in invasive pneumococcal disease Cellular microbiology 2013;15 (6):870-881 [PubMed]
  • Kasanmoentalib E. Soemirien, Brouwer Matthijs C., van de Beek Diederik Update on bacterial meningitis: epidemiology, trials and genetic association studies Current opinion in neurology 2013;26 (3):282-288 [PubMed]

2012

  • Heckenberg Sebastiaan G. B., Brouwer Matthijs C., van der Ende Arie, van de Beek Diederik Adjunctive dexamethasone in adults with meningococcal meningitis Neurology 2012;79 (15):1563-1569 [PubMed]
  • van de Beek Diederik, Brouwer Matthijs C., Thwaites Guy E., Tunkel Allan R. Advances in treatment of bacterial meningitis Lancet 2012;380 (9854):1693-1702 [PubMed]
  • Adriani K. S., Brouwer M. C., van der Ende A., van de Beek D. Bacterial meningitis in pregnancy: report of six cases and review of the literature Clinical microbiology and infection 2012;18 (4):345-351 [PubMed]
  • Brouwer M. C., van de Beek D. Bacteriële meningitis Nederlands tijdschrift voor tandheelkunde 2012;119 (5):238-242 [PubMed]
  • Jim Kin K., Brouwer Matthijs C., van der Ende Arie, van de Beek Diederik Cerebral abscesses in patients with bacterial meningitis Journal of infection 2012;64 (2):236-238 [PubMed]
  • Schut Ewout S., Lucas Marjolein J., Brouwer Matthijs C., Vergouwen Mervyn D. I., van der Ende Arie, van de Beek Diederik Cerebral Infarction in Adults with Bacterial Meningitis Neurocritical care 2012;16 (3):421-427 [PubMed]
  • Fritz Daan, Brouwer Matthijs C., van de Beek Diederik Dexamethasone and long-term survival in bacterial meningitis Neurology 2012;79 (22):2177-2179 [PubMed]
  • Brouwer Matthijs C., Thwaites Guy E., Tunkel Allan R., van de Beek Diederik Dilemmas in the diagnosis of acute community-acquired bacterial meningitis Lancet 2012;380 (9854):1684-1692 [PubMed]
  • Brouwer Matthijs C., van der Ende Arie, Baas Frank, van de Beek Diederik Genetic variation in GLCCI1 and dexamethasone in bacterial meningitis Journal of infection 2012;65 (5):465-467 [PubMed]
  • Adriani Kirsten S., Brouwer Matthijs C., Baas Frank, Zwinderman Aeilko H., van der Ende Arie, van de Beek Diederik Genetic Variation in the beta 2-Adrenocepter Gene Is Associated with Susceptibility to Bacterial Meningitis in Adults PLoS ONE 2012;7 (5):e37618 [PubMed]
  • Heckenberg S. G. B., Brouwer M. C., van der Ende A., Hensen E. F., van de Beek D. Hearing loss in adults surviving pneumococcal meningitis is associated with otitis and pneumococcal serotype Clinical microbiology and infection 2012;18 (9):849-855 [PubMed]
  • Mook-Kanamori Barry B., Fritz Daan, Brouwer Matthijs C., van der Ende Arie, van de Beek Diederik Intracerebral Hemorrhages in Adults with Community Associated Bacterial Meningitis in Adults: Should We Reconsider Anticoagulant Therapy? PLoS ONE 2012;7 (9):e45271 [PubMed]
  • Piet Jurgen R., Brouwer Matthijs C., Exley Rachel, van der Veen Stijn, van de Beek Diederik, van der Ende Arie Meningococcal Factor H Binding Protein fHbpd184 Polymorphism Influences Clinical Course of Meningococcal Meningitis PLoS ONE 2012;7 (10):e47973 [PubMed]
  • Costerus Joost M., van de Beek Diederik, Brouwer Matthijs C. Nosocomial meningitis caused by gas producing Klebsiella pneumoniae BMJ case reports 2012;2012:bcr1120115137 [PubMed]
  • Jim Kin K., Brouwer Matthijs C., van der Ende Arie, van de Beek Diederik Subdural empyema in bacterial meningitis Neurology 2012;79 (21):2133-2139 [PubMed]
  • Adriani Kirsten S., van de Beek Diederik, Troost Dirk, Brouwer Matthijs C. The Diagnostic Pitfall of Infratentorial Subdural Empyema Archives of neurology 2012;69 (8):1076-1077 [PubMed]
  • Schut Ewout S., Brouwer Matthijs C., Scarborough Matthew, Mai Nguyen Thi Hoang, Thwaites Guy E., Farrar Jeremy J., Reitsma Johannes B., van de Beek Diederik Validation of a Dutch Risk Score Predicting Poor Outcome in Adults with Bacterial Meningitis in Vietnam and Malawi PLoS ONE 2012;7 (3):e34311 [PubMed]

2011

  • Brouwer Matthijs C., Spanjaard Lodewijk, Prins Jan M., van der Ley Peter, van de Beek Diederik, van der Ende Arie Association of chronic meningococcemia with infection by meningococci with underacylated lipopolysaccharide Journal of infection 2011;62 (6):479-483 [PubMed]
  • Woehrl Bianca, Brouwer Matthijs C., Murr Carmen, Heckenberg Sebastiaan G. B., Baas Frank, Pfister Hans W., Zwinderman Aeilko H., Morgan B. Paul, Barnum Scott R., van der Ende Arie, Koedel Uwe, van de Beek Diederik Complement component 5 contributes to poor disease outcome in humans and mice with pneumococcal meningitis Journal of clinical investigation 2011;121 (10):3943-3953 [PubMed]
  • Brouwer Matthijs C., van de Beek Diederik Glycerol in bacterial meningitis: one strike and out? Lancet infectious diseases 2011;11 (4):257-258 [PubMed]

2010

  • Brouwer Matthijs C., Kasanmoentalib Erna S., Opstelten Frank W. J., van der Ende Arie, van de Beek Diederik A horse bite to remember Lancet 2010;376 (9747):1194 [PubMed]
  • Brouwer Matthijs C., van de Beek Diederik An agitated man with earache BMJ (Clinical research ed.) 2010;341:c3824 [PubMed]
  • Brouwer Matthijs C. Bacterial meningitis in adults: clinical characteristics, risk factors and adjunctive treatment 2010. 258p. ISBN 9789090255873. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Vermeulen M.; Co-supervisor: van de Beek D.)
  • Brouwer Matthijs C., McIntyre Peter, de Gans Jan, Prasad Kameshwar, van de Beek Diederik Corticosteroids for acute bacterial meningitis Cochrane database of systematic reviews (Online) 2010;2010 (9):CD004405 [PubMed]
  • Klein Matthias, Koedel Uwe, Kastenbauer Stefan, Pfister Hans-Walter, van de Beek Diederik, Schut Ewout S., Brouwer Matthijs C., Steiner Israel Delayed cerebral thrombosis after initial good recovery from pneumococcal meningitis: past as prologue: delayed stroke as a parainfectious process of bacterial meningitis? Neurology 2010;75 (2):193; author reply 193-193; author reply 194 [PubMed]
  • Brouwer Matthijs C., Tunkel Allan R., van de Beek Diederik Epidemiology, Diagnosis, and Antimicrobial Treatment of Acute Bacterial Meningitis Clinical microbiology reviews 2010;23 (3):467-+ [PubMed]
  • Brouwer Matthijs C., Read Robert C., van de Beek Diederik Host genetics and outcome in meningococcal disease: a systematic review and meta-analysis Lancet infectious diseases 2010;10 (4):262-274 [PubMed]
  • Soemirien Kasanmoentalib E., Brouwer Matthijs C., van der Ende Arie, van de Beek Diederik Hydrocephalus in adults with community-acquired bacterial meningitis Neurology 2010;75 (10):918-923 [PubMed]
  • Brouwer M. C., Heckenberg S. G. B., de Gans J., Spanjaard L., Reitsma J. B., van de Beek D. Nationwide implementation of adjunctive dexamethasone therapy for pneumococcal meningitis Neurology 2010;75 (17):1533-1539 [PubMed]
  • van de Beek Diederik, Brouwer Matthijs C. No difference between short-course and long-course antibiotics for bacterial meningitis in children, but available evidence limited Evidence-based medicine 2010;15 (1):6-7 [PubMed]
  • van de Beek Diederik, Brouwer Matthijs C. Randomised controlled trial: Hearing loss after bacterial meningitis is predicted by presenting status and young age; effectiveness of adjuvant dexamethasone or glycerol unclear Evidence-based medicine 2010;15 (2):39-40 [PubMed]

2009

  • Brouwer Matthijs C., Keizerweerd Gabriella D., de Gans Jan, Spanjaard Lodewijk, van de Beek Diederik Community acquired Staphylococcus aureus meningitis in adults Scandinavian journal of infectious diseases 2009;41 (5):375-377 [PubMed]
  • Schut E. S., Brouwer M. C., de Gans J., Florquin S., Troost D., van de Beek D. Delayed cerebral thrombosis after initial good recovery from pneumococcal meningitis Neurology 2009;73 (23):1988-1995 [PubMed]
  • Brouwer Matthijs C., van de Beek Diederik Genetics in meningococcal disease: one step beyond Clinical infectious diseases 2009;48 (5):595-597 [PubMed]
  • Brouwer Matthijs C., de Gans Jan, Heckenberg Sebastiaan G. B., Zwinderman Aeilko H., van der Poll Tom, van de Beek Diederik Host genetic susceptibility to pneumococcal and meningococcal disease: a systematic review and meta-analysis Lancet infectious diseases 2009;9 (1):31-44 [PubMed]
  • Brouwer M. C., de Gans J., Willemse R. B., van de Beek D. Neurological picture. Sarcoidosis presenting with hydrocephalus Journal of neurology, neurosurgery, and psychiatry 2009;80 (5):550-551 [PubMed]

2008

  • Heckenberg Sebastiaan G. B., de Gans Jan, Brouwer Matthijs C., Weisfelt Martijn, Piet Jurgen R., Spanjaard Lodewijk, van der Ende Arie, van de Beek Diederik Clinical features, outcome, and meningococcal genotype in 258 adults with meningococcal meningitis: a prospective cohort study Medicine 2008;87 (4):185-192 [PubMed]
  • Brouwer M. C., de Gans J., Heckenberg S. G. B., Kuiper H., van Lieshout H. B. M., van de Beek D. Vertebral osteomyelitis complicating pneumococcal meningitis Neurology 2008;71 (8):612-613 [PubMed]

2007

  • Brouwer M. C., van de Beek D., Heckenberg S. G. B., Spanjaard L., de Gans J. Community-acquired Haemophilus influenzae meningitis in adults Clinical microbiology and infection 2007;13 (4):439-442 [PubMed]
  • Adriani Kirsten S., van de Beek Diederik, Brouwer Matthijs C., Spanjaard Lodewijk, de Gans Jan Community-acquired recurrent bacterial meningitis in adults Clinical infectious diseases 2007;45 (5):e46-e51 [PubMed]
  • van de Beek Diederik, Brouwer Matthijs, de Gans Jan Hypernatremia in bacterial meningitis Journal of infection 2007;55 (4):381-382 [PubMed]
  • Brouwer M. C., van de Beek D., Heckenberg S. G. B., Spanjaard L., de Gans J. Hyponatraemia in adults with community-acquired bacterial meningitis QJM 2007;100 (1):37-40 [PubMed]
  • Richard Edo, Brouwer Matthijs C., Portegies Peter Primary central nervous system lymphomain: Marianne de Visser, editors. Handbook of Clinical Neurology. Amsterdam: Elsevier; 2007. p. 221-228, ISBN 9780444518996

2006

  • Brouwer Matthijs C., van de Beek Diederik, Heckenberg Sebastiaan G. B., Spanjaard Lodewijk, de Gans Jan Community-acquired Listeria monocytogenes meningitis in adults Clinical infectious diseases 2006;43 (10):1233-1238 [PubMed]
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