P.L. Klarenbeek MD PhD publications

2020

• Reijers I. L. M., Hilhorst M., Tan M., Klarenbeek P. L., Hak A. E., Blank C. U. Acrocyanosis after neoadjuvant ipilimumab plus nivolumab: A case report Clinical and experimental rheumatology 2020;38 (5):1031-1032 [PubMed]
• Kavazović Inga, Han Hongya, Balzaretti Giulia, Slinger Erik, Lemmermann Niels A. W., ten Brinke Anja, Merkler Doron, Koster Jan, Bryceson Yenan T., de Vries Niek, Jonjić Stipan, Klarenbeek Paul L., Polić Bojan, Eldering Eric, Wensveen Felix M. Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity PLoS biology 2020;18 (3):e3000648 [PubMed]
• Vroman Heleen, Balzaretti Giulia, Belderbos Robert A., Klarenbeek Paul L., van Nimwegen Menno, Bezemer Koen, Cornelissen Robin, Niewold Ilse T. G., van Schaik Barbera D., van Kampen Antione H., Aerts Joachim G. J. V., de Vries Niek, Hendriks Rudi W. T cell receptor repertoire characteristics both before and following immunotherapy correlate with clinical response in mesothelioma Journal for immunotherapy of cancer 2020;8 (1) [PubMed]

2019

• Schreurs Renée R. C. E., Baumdick Martin E., Sagebiel Adrian F., Kaufmann Max, Mokry Michal, Klarenbeek Paul L., Schaltenberg Nicola, Steinert Fenja L., van Rijn Jorik M., Drewniak Agata, The Sarah-May M. L., Bakx Roel, Derikx Joep P. M., de Vries Niek, Corpeleijn Willemijn E., Pals Steven T., Gagliani Nicola, Friese Manuel A., Middendorp Sabine, Nieuwenhuis Edward E. S., Reinshagen Konrad, Geijtenbeek Teunis B. H., van Goudoever Johannes B., Bunders Madeleine J. Human Fetal TNF-α-Cytokine-Producing CD4 + Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life Immunity 2019;50 (2):462-476.e8 [PubMed]
• Al-Soudi A, Doorenspleet M E, Esveldt R E, Burgemeister L T, Hak A E, van den Born B J H, Tas S W, van Vollenhoven R F, Klarenbeek P L, de Vries N IgG4:IgG RNA ratio differentiates active disease from remission in granulomatosis with polyangiitis: a new disease activity marker? A cross-sectional and longitudinal study Arthritis research & therapy 2019;21 (1):43 [PubMed]
• Pollastro Sabrina, Klarenbeek Paul L., Doorenspleet Marieke E., van Schaik Barbera D. C., Esveldt Rebecca E. E., Thurlings Rogier M., Boumans Maria J. H., Gerlag Danielle M., Tak Paul P., Vos Koen, Baas Frank, van Kampen Antoine H. C., de Vries Niek Non-response to rituximab therapy in rheumatoid arthritis is associated with incomplete disruption of the B cell receptor repertoire Annals of the rheumatic diseases 2019;78 (10):1339-1345 [PubMed]

2018

• Musters Anne, Klarenbeek Paul L., Doorenspleet Marieke E., Balzaretti Giulia, Esveldt Rebecca E. E., van Schaik Barbera D. C., Jongejan Aldo, Tas Sander W., van Kampen Antoine H. C., Baas Frank, de Vries Niek In rheumatoid arthritis, synovitis at different inflammatory sites is dominated by shared but patient-specific T cell clones Journal of immunology (Baltimore, Md. 2018;201 (2):417-422 [PubMed]

2017

• Reshetova Polina, van Schaik Barbera D. C., Klarenbeek Paul L., Doorenspleet Marieke E., Esveldt Rebecca E. E., Tak Paul-Peter, Guikema Jeroen E. J., de Vries Niek, van Kampen Antoine H. C. Computational Model Reveals Limited Correlation between Germinal Center B-Cell Subclone Abundancy and Affinity: Implications for Repertoire Sequencing Frontiers in immunology 2017;8:221 [PubMed]
• Tak Paul P., Doorenspleet Marieke E., de Hair Maria J. H., Klarenbeek Paul L., van Beers-Tas Marian H., van Kampen Antoine H. C., van Schaardenburg Dirkjan, Gerlag Danielle M., Baas Frank, de Vries Niek Dominant B cell receptor clones in peripheral blood predict onset of arthritis in individuals at risk for rheumatoid arthritis Annals of the rheumatic diseases 2017;76 (11):1924-1930 [PubMed]

2016

• Doorenspleet Marieke E., Hubers Lowiek M., Culver Emma L., Maillette de Buy Wenniger Lucas J., Klarenbeek Paul L., Chapman Roger W., Baas Frank, van de Graaf Stan F., Verheij Joanne, van Gulik Thomas M., Barnes Eleanor, Beuers Ulrich, de Vries Niek Immunoglobulin G4(+) B-cell receptor clones distinguish immunoglobulin G 4-related disease from primary sclerosing cholangitis and biliary/pancreatic malignancies Hepatology (Baltimore, Md.) 2016;64 (2):501-507 [PubMed]

2015

• Remmerswaal Ester B. M., Klarenbeek Paul L., Alves Nuno L., Doorenspleet Marieke E., van Schaik Barbera D. C., Esveldt Rebecca E. E., Idu Mirza M., van Leeuwen Ester M. M., van der Bom-Baylon Nelly, van Kampen Antoine H. C., Koch Sven D., Pircher Hanspeter, Bemelman Frederike J., ten Brinke Anja, Baas Frank, ten Berge Ineke J. M., van Lier Rene A. W., de Vries Niek Clonal evolution of CD8+ T cell responses against latent viruses: relationship among phenotype, localization, and function Journal of virology 2015;89 (1):568-580 [PubMed]
• Hubers Lowiek M., Maillette de Buy Wenniger Lucas J., Doorenspleet Marieke E., Klarenbeek Paul L., Verheij Joanne, Rauws Erik A., van Gulik Thomas M., Oude Elferink Ronald P. J., van de Graaf Stan F. J., de Vries Niek, Beuers Ulrich IgG4-associated cholangitis: a comprehensive review Clinical reviews in allergy & immunology 2015;48 (2-3):198-206 [PubMed]
• Beuers Ulrich, Hubers Lowiek M., Doorenspleet Marieke, Maillette de Buy Wenniger Lucas, Klarenbeek Paul L., Boonstra Kirsten, Ponsioen Cyriel, Rauws Erik, de Vries Niek IgG4-Associated Cholangitis--A Mimic of PSC Digestive diseases (Basel, Switzerland) 2015;33 (Suppl. 2):176-180 [PubMed]
• Klarenbeek Paul L., Doorenspleet Marieke E., Esveldt Rebecca E. E., van Schaik Barbera D. C., Lardy Neubury, van Kampen Antoine H. C., Tak Paul P., Plenge Robert M., Baas Frank, de Bakker Paul I. W., de Vries Niek Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction PLoS ONE 2015;10 (10):e0140815 [PubMed]

2014

• van Schaik Barbera, Klarenbeek Paul, Doorenspleet Marieke, van Kampen Antoine, Moody D. Branch, de Vries Niek, van Rhijn Ildiko Discovery of invariant T cells by next-generation sequencing of the human TCR α-chain repertoire Journal of immunology (Baltimore, Md. 2014;193 (10):5338-5344 [PubMed]
• Angin Mathieu, Klarenbeek Paul L., King Melanie, Sharma Siddhartha M., Moodley Eshia S., Rezai Ashley, Piechocka-Trocha Alicja, Toth Ildiko, Chan Andrew T., Goulder Philip J., Ndung'u Thumbi, Kwon Douglas S., Addo Marylyn M. Regulatory T cells expanded from HIV-1-infected individuals maintain phenotype, TCR repertoire and suppressive capacity PLoS ONE 2014;9 (2):e86920 [PubMed]
• Doorenspleet M. E., Klarenbeek P. L., de Hair M. J. H., van Schaik B. D. C., Esveldt R. E. E., van Kampen A. H. C., Gerlag D. M., Musters A. [=Anne], Baas F., Tak P. P., de Vries N. [=Niek] Rheumatoid arthritis synovial tissue harbours dominant B-cell and plasma-cell clones associated with autoreactivity Annals of the rheumatic diseases 2014;73 (4):756-762 [PubMed]

2013

• Kuijpers Taco W., van Leeuwen Ester M. M., Barendregt Barbara H., Klarenbeek Paul, Aan de Kerk Daan J., Baars Paul A., Jansen Machiel H., de Vries Niek, van Lier René A. W., van der Burg Mirjam A reversion of an IL2RG mutation in combined immunodeficiency providing competitive advantage to the majority of CD8+ T cells Haematologica 2013;98 (7):1030-1038 [PubMed]
• Klarenbeek Paul L. Beyond the keyhole perspective. Quantitative and full repertoire imaging of T- and B-cell receptors using next generation sequencing 2013. 145p. ISBN 9789461823601. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Tak P. P., Baas F.; Co-supervisor: de Vries Niek)
• Maillette de Buy Wenniger Lucas J., Doorenspleet Marieke E., Klarenbeek Paul L., Verheij Joanne, Baas Frank, Elferink Ronald P. Oude, Tak Paul P., de Vries Niek, Beuers Ulrich Immunoglobulin G4+ clones identified by next-generation sequencing dominate the B cell receptor repertoire in immunoglobulin G4 associated cholangitis Hepatology (Baltimore, Md.) 2013;57 (6):2390-2398 [PubMed]
• Larman H. Benjamin, Laserson Uri, Querol Luis, Verhaeghen Katrijn, Solimini Nicole L., Xu George Jing, Klarenbeek Paul L., Church George M., Hafler David A., Plenge Robert M., Nigrovic Peter A., de Jager Philip L., Weets Ilse, Martens Geert A., O'Connor Kevin C., Elledge Stephen J. PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis Journal of autoimmunity 2013;43:1-9 [PubMed]
• Wensveen Felix M., Klarenbeek Paul L., van Gisbergen Klaas P. J. M., Pascutti Maria F., Derks Ingrid A. M., van Schaik Barbera D. C., ten Brinke Anja, de Vries Niek, Cekinovic Durdica, Jonjic Stipan, van Lier René A. W., Eldering Eric Pro-apoptotic protein Noxa regulates memory T cell population size and protects against lethal immunopathology Journal of immunology (Baltimore, Md. 2013;190 (3):1180-1191 [PubMed]

2012

• Klarenbeek P. L., Remmerswaal E. B. M., ten Berge I. J. M., Doorenspleet M. E., van Schaik B. D. C., Esveldt R. E. E., Koch S. D., ten Brinke A., van Kampen A. H. C., Bemelman F. J., Tak P. P., Baas F., de Vries N. [=Niek], van Lier R. A. W. Deep sequencing of antiviral T-cell responses to HCMV and EBV in humans reveals a stable repertoire that is maintained for many years PLoS pathogens 2012;8 (9):e1002889 [PubMed]
• Cantaert Tineke, Doorenspleet Marieke E., Francosalinas Gabriela, Paramarta Jaqueline E., Klarenbeek Paul L., Tiersma Yvonne, van der Loos Chris M., de Vries Niek, Tak Paul Peter, Baeten Dominique L. Increased numbers of CD5+ B lymphocytes with a regulatory phenotype in spondylarthritis Arthritis and rheumatism 2012;64 (6):1859-1868 [PubMed]
• Klarenbeek P. L., de Hair M. J. H., Doorenspleet M. E., van Schaik B. D. C., Esveldt R. E. E., van de Sande M. G. H., Cantaert T., Gerlag D. M., Baeten D., van Kampen A. H. C., Baas F., Tak P. P., de Vries N. [=Niek] Inflamed target tissue provides a specific niche for highly expanded T-cell clones in early human autoimmune disease Annals of the rheumatic diseases 2012;71 (6):1088-1093 [PubMed]
• Bunders Madeleine J., van der Loos Chris M., Klarenbeek Paul L., van Hamme John L., Boer Kees, Wilde Jim C. H., de Vries Niek, van Lier Rene A. W., Kootstra Neeltje, Pals Steven T., Kuijpers Taco W. Memory CD4(+)CCR5(+) T cells are abundantly present in the gut of newborn infants to facilitate mother-to-child transmission of HIV-1 Blood 2012;120 (22):4383-4390 [PubMed]

2011

• van de Sande M. G. H., de Hair M. J. H., van der Leij C., Klarenbeek P. L., Bos W. H., Smith M. D., Maas M., de Vries N. [=Niek], van Schaardenburg D., Dijkmans B. A. C., Gerlag D. M., Tak P. P. Different stages of rheumatoid arthritis: features of the synovium in the preclinical phase Annals of the rheumatic diseases 2011;70 (5):772-777 [PubMed]
• van Gisbergen Klaas P. J. M., Klarenbeek Paul L., Kragten Natasja A. M., Unger Peter-Paul A., Nieuwenhuis Marieke B. B., Wensveen Felix M., ten Brinke Anja, Tak Paul P., Eldering Eric, Nolte Martijn A., van Lier Rene A. W. The costimulatory molecule CD27 maintains clonally diverse CD8(+) T cell responses of low antigen affinity to protect against viral variants Immunity 2011;35 (1):97-108 [PubMed]

2010

• Klarenbeek Paul L., Tak Paul P., van Schaik Barbera D. C., Zwinderman Aeilko H., Jakobs Marja E., Zhang Zhuoli, van Kampen Antoine H. C., van Lier René A. W., Baas Frank, de Vries Niek Human T-cell memory consists mainly of unexpanded clones Immunology letters 2010;133 (1):42-48 [PubMed]

2009

• Cantaert Tineke, Brouard Sophie, Thurlings Rogier M., Pallier Annaick, Salinas Gabriela Franco, Braud Christophe, Klarenbeek Paul L., de Vries Niek, Zhang Yiping, Soulillou Jean-Paul, Tak Paul P., Baeten Dominique Alterations of the Synovial T Cell Repertoire in Anti-Citrullinated Protein Antibody-Positive Rheumatoid Arthritis Arthritis and rheumatism 2009;60 (7):1944-1956 [PubMed]

2008

• Wijbrandts Carla A., Remans Philip H., Klarenbeek Paul L., Wouters Diana, van den Bergh Weerman Marius A., Smeets Tom J., Vervoordeldonk Margriet J., Baeten Dominique, Tak Paul P. Analysis of Apoptosis in Peripheral Blood and Synovial Tissue Very Early After Initiation of Infliximab Treatment in Rheumatoid Arthritis Patients Arthritis and rheumatism 2008;58 (11):3330-3339 [PubMed]

2005

• Adriaansen J., Tas S. W., Klarenbeek P. L., Bakker A. C., Apparailly F., Firestein G. S., Jorgensen C., Vervoordeldonk M. J. B. M., Tak P. P. Enhanced gene transfer to arthritic joints using adeno-associated virus type 5: implications for intra-articular gene therapy Annals of the rheumatic diseases 2005;64 (12):1677-1684 [PubMed]