B.A. Wevers MSc publications

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Publications MSc B.A. Wevers

Position
Research Associate
Main activities
Research
Specialisation
Molecular biology, signal transduction, innate immunology
Focus of research

Antifungal immunity. Opportunistic fungi represent a serious health problem by causing systemic life-threatening infections in individuals who are immune compromised, including HIV-1/AIDS and cancer patients. Effective phagocytic clearance of fungal pathogens requires intact Th-17 and Th1 immune responses, for mobilization and activation of neutrophils, respectively. Recognition of fungal cell wall carbohydrates by C-type lectins on human dendritic cells and subsequent cytokine production is crucial for the orchestration of protective T helper cell polarization. We are identifying C-type lectins that interact with different fungal species and how these C-type lectins induce adaptive immunity. In particular we are investigating signaling by C-type lectins such as dectin-1 and dectin-2.

2019

  • Platteel Anouk C. M., Wevers Brigitte A., Lim Johan, Bakker Jaap A., Bontkes Hetty J., Curvers Joyce, Damoiseaux Jan, Heron Michiel, de Kort Gijs, Limper Maarten, van Lochem Ellen G., Mulder A. H. Leontine, Saris Christiaan G. J., van der Valk Hester, van der Kooi Anneke J., van Leeuwen Ester M. M., Veltkamp Marcel, Schreurs Marco W. J., Meek Bob, Hamann D. rte Frequencies and clinical associations of myositis-related antibodies in The Netherlands: A one-year survey of all Dutch patients Journal of Translational Autoimmunity 2019;2 [PubMed]

2014

  • Wevers Brigitte A. C-type lectin signaling in dendritic cells. Molecular control of antifungal inflammation 2014. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Geijtenbeek T. B. H.; Co-supervisor: Gringhuis S. I.)
  • Gringhuis Sonja I., Kaptein Tanja M., Wevers Brigitte A., van der Vlist Michiel, Klaver Elsenoor J., van Die Irma, Vriend Lianne E. M., de Jong Marein A. W. P., Geijtenbeek Teunis B. H. Fucose-based PAMPs prime dendritic cells for follicular T helper cell polarization via DC-SIGN-dependent IL-27 production Nature communications 2014;5:5074 [PubMed]
  • Gringhuis Sonja I., Kaptein Tanja M., Wevers Brigitte A., Mesman Annelies W., Geijtenbeek Teunis B. H. Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKε- and CYLD-dependent Bcl3 activation Nature communications 2014;5:3898 [PubMed]
  • Wevers Brigitte A., Kaptein Tanja M., Zijlstra-Willems Esther M., Theelen Bart, Boekhout Teun, Geijtenbeek Teunis B. H., Gringhuis Sonja I. Fungal engagement of the C-type lectin mincle suppresses dectin-1-induced antifungal immunity Cell host & microbe 2014;15 (4):494-505 [PubMed]

2013

  • Wevers Brigitte A., Geijtenbeek Teunis B. H., Gringhuis Sonja I. C-type lectin receptors orchestrate antifungal immunity Future microbiology 2013;8 (7):839-854 [PubMed]

2012

  • Gringhuis Sonja I., Kaptein Tanja M., Wevers Brigitte A., Theelen Bart, van der Vlist Michiel, Boekhout Teun, Geijtenbeek Teunis B. H. Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1 beta via a noncanonical caspase-8 inflammasome Nature immunology 2012;13 (3):246-U63 [PubMed]

2011

  • Gringhuis Sonja I., Wevers Brigitte A., Kaptein Tanja M., van Capel Toni M. M., Theelen Bart, Boekhout Teun, de Jong Esther C., Geijtenbeek Teunis B. H. Selective C-Rel Activation via Malt1 Controls Anti-Fungal T-H-17 Immunity by Dectin-1 and Dectin-2 PLoS pathogens 2011;7 (1):e1001259 [PubMed]

2010

  • Wevers Brigitte A., van der Hoek Lia Renin-angiotensin system in human coronavirus pathogenesis Future Virology 2010;5 (2):145-161

2009

  • Gringhuis Sonja I., den Dunnen Jeroen, Litjens Manja, van der Vlist Michiel, Wevers Brigitte, Bruijns Sven C. M., Geijtenbeek Teunis B. H. Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk Nature immunology 2009;10 (2):203-213 [PubMed]
  • Wevers Brigitte A., van der Hoek Lia Recently Discovered Human Coronaviruses Clinics in laboratory medicine 2009;29 (4):715-+ [PubMed]