N.T.P. Bakker PhD publications

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Publications N.T.P. Bakker PhD

Position
Assistant Professor
Main activities
Education, Research
Specialisation
Vascular Biology
Focus of research

Experimental work on vascular remodeling associated with altered blood flow, hypertension and atherosclerosis. Role of vascular tone, inflammation and transglutaminases in arterial remodeling.

Currently I focus on the role of the brain vasculature in cognitive function. In particular, I am interested in the perivascular pathway of amyloid beta removal. The characteristics, its driving force, and impact of vascular pathology on this transport pathway are currently unknown and of great potential importance in the development of dementia.

2020

  • Naessens Daphne M. P., Coolen Bram F., de Vos Judith, Vanbavel Ed, Strijkers Gustav J., Bakker Erik N. T. P. Altered brain fluid management in a rat model of arterial hypertension Fluids and barriers of the CNS 2020;17 (1) [PubMed]
  • Dubacher Nicolo, Münger Justyna, Gorosabel Maria C., Crabb Jessica, Ksiazek Agnieszka A., Caspar Sylvan M., Bakker Erik N. T. P., van Bavel Ed, Ziegler Urs, Carrel Thierry, Steinmann Beat, Zeisberger Steffen, Meienberg Janine, Matyas Gabor Celiprolol but not losartan improves the biomechanical integrity of the aorta in a mouse model of vascular Ehlers-Danlos syndrome Cardiovascular research 2020;116 (2):457-465 [PubMed]
  • Taherzadeh Zhila, van Montfrans G. A., van der Zee C. E. E. M., Streijger F., Bakker E. N. T. P., Brewster L. M. Structure and function of resistance arteries from BB-creatine kinase and ubiquitous Mt-creatine kinase double knockout mice Amino acids 2020;52 (6-7):1033-1041 [PubMed]

2019

  • van der Wijk Anne-Eva, Lachkar Nadia, de Vos Judith, Grootemaat Anita E., van der Wel Nicole N., Hordijk Peter L., Bakker Erik N. T. P., vanBavel Ed Extravasation of Microspheres in a Rat Model of Silent Brain Infarcts Stroke; a journal of cerebral circulation 2019;50 (6):1590-1594 [PubMed]
  • Bakker Erik N. T. P., Naessens Daphne M. P., VanBavel Ed Paravascular spaces: entry to or exit from the brain? Experimental physiology 2019;104 (7):1013-1017 [PubMed]

2018

  • Naessens Daphne M. P., de Vos Judith, Vanbavel Ed, Bakker Erik N. T. P. Blood-brain and blood-cerebrospinal fluid barrier permeability in spontaneously hypertensive rats Fluids and barriers of the CNS 2018;15 (1) [PubMed]
  • Bedussi Beatrice, Almasian Mitra, de Vos Judith, VanBavel Ed, Bakker Erik N. T. P. Paravascular spaces at the brain surface: Low resistance pathways for cerebrospinal fluid flow Journal of cerebral blood flow and metabolism 2018;38 (4):719-726 [PubMed]
  • Palao Garcia Teresa J. Small arteries, big problems: New insights in the mechanisms of small artery remodeling in hypertension 2018. ISBN 9789463611534. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van Bavel E. T.; Co-supervisor: Bakker N. T. P.)
  • Palao T., van Weert A., de Leeuw A., de Vos J., Bakker E. N. T. P., van Bavel E. Sustained conduction of vasomotor responses in rat mesenteric arteries in a two-compartment in vitro set-up Acta physiologica (Oxford, England) 2018;224 (3) [PubMed]
  • Palao Teresa, Medzikovic Lejla, Rippe Catarina, Wanga Shaynah, Al-Mardini Claudia, van Weert Angela, de Vos Judith, van der Wel Nicole N., van Veen Henk A., van Bavel Ed T., Swärd Karl, de Waard Vivian, Bakker Erik N. TP Thrombospondin-4 mediates cardiovascular remodelling in angiotensin II-induced hypertension Cardiovascular pathology 2018;35:12-19 [PubMed]

2017

  • Bedussi Beatrice Brain washing: Transport of cerebral extracellular fluids and solutes 2017. 127p. ISBN 9789492683977. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van Bavel E. T.; Co-supervisor: Bakker N. T. P.)
  • Di Russo Jacopo, Luik Anna-Liisa, Yousif Lema, Budny Sigmund, Oberleithner Hans, Hofschröer Verena, Klingauf Juergen, van Bavel Ed, Bakker Erik Ntp, Hellstrand Per, Bhattachariya Anirban, Albinsson Sebastian, Pincet Frederic, Hallmann Rupert, Sorokin Lydia M. Endothelial basement membrane laminin 511 is essential for shear stress response EMBO journal 2017;36 (2):183-201 [PubMed]
  • Bedussi Beatrice, Naessens Daphne M. P., de Vos Judith, Olde Engberink Rik, Wilhelmus Micha M. M., Richard Edo, ten Hove Malyssa, VanBavel Ed, Bakker Erik N. T. P. Enhanced interstitial fluid drainage in the hippocampus of spontaneously hypertensive rats Scientific reports 2017;7 (1):744 [PubMed]
  • Rippe Catarina, Zhu Baoyi, Krawczyk Katarzyna K., van Bavel Ed, Albinsson Sebastian, Sjölund Jonas, Bakker Erik N. T. P., Swärd Karl Hypertension reduces soluble guanylyl cyclase expression in the mouse aorta via the Notch signaling pathway Scientific reports 2017;7 (1):1334 [PubMed]
  • Schwarz Janina C. V., van Lier Monique G. J. T. B., Bakker Erik N. T. P., de Vos Judith, Spaan Jos A. E., VanBavel Ed, Siebes Maria Optimization of Vascular Casting for Three-Dimensional Fluorescence Cryo-Imaging of Collateral Vessels in the Ischemic Rat Hindlimb Microscopy and microanalysis 2017;23 (1):77-87 [PubMed]
  • Bedussi Beatrice, van der Wel Nicole N., de Vos Judith, van Veen Henk, Siebes Maria, VanBavel Ed, Bakker Erik N. T. P. Paravascular channels, cisterns, and the subarachnoid space in the rat brain: A single compartment with preferential pathways Journal of cerebral blood flow and metabolism 2017;37 (4):1374-1385 [PubMed]

2016

  • Bakker Erik N. T. P., Bacskai Brian J., Arbel-Ornath Michal, Aldea Roxana, Bedussi Beatrice, Morris Alan W. J., Weller Roy O., Carare Roxana O. Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases Cellular and molecular neurobiology 2016;36 (2):181-194 [PubMed]
  • Palao Teresa, Rippe Catarina, van Veen Henk, VanBavel Ed, Swärd Karl, Bakker Erik N. T. P. Thrombospondin-4 knockout in hypertension protects small-artery endothelial function but induces aortic aneurysms American journal of physiology. Heart and circulatory physiology 2016;310 (11):H1486-H1493 [PubMed]

2015

  • Guvenc Tuna Bilge, Lachkar Nadia, de Vos Judith, Bakker Erik N. T. P., VanBavel Ed Cerebral Artery Remodeling in Rodent Models of Subarachnoid Hemorrhage Journal of vascular research 2015;52 (2):103-115 [PubMed]
  • Bedussi Beatrice, van Lier Monique G. J. T. B., Bartstra Jonas W., de Vos Judith, Siebes Maria, VanBavel Ed, Bakker Erik N. T. P. Clearance from the mouse brain by convection of interstitial fluid towards the ventricular system Fluids and barriers of the CNS 2015;12 (1):23 [PubMed]
  • Palao Teresa, Swärd Karl, Jongejan Aldo, Moerland Perry D., de Vos Judith, van Weert Angela, Arribas Silvia M., Groma Gergely, VanBavel Ed, Bakker Erik N. T. P. Gene Expression and MicroRNA Expression Analysis in Small Arteries of Spontaneously Hypertensive Rats. Evidence for ER Stress PLoS ONE 2015;10 (9):e0137027 [PubMed]

2014

  • Bakker Erik N. T. P., Groma Gergely, Spijkers Léon J. A., de Vos Judith, van Weert Angela, van Veen Henk, Everts Vincent, Arribas Silvia M., VanBavel Ed Heterogeneity in arterial remodeling among sublines of spontaneously hypertensive rats PLoS ONE 2014;9 (9):e107998 [PubMed]
  • Tuna Bilge Guvenc Smooth muscle cell function and organization of the resistance artery wall 2014. 204p. ISBN 9789088918094. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van Bavel E. T.; Co-supervisor: Bakker E. N. T. P.)
  • Wilhelmus Micha M. M., de Jager Mieke, Bakker Erik N. T. P., Drukarch Benjamin Tissue transglutaminase in Alzheimer's disease: involvement in pathogenesis and its potential as a therapeutic target Journal of Alzheimer s disease 2014;42 (Suppl. 3):S289-S303 [PubMed]

2013

  • Huelsz-Prince Guizela, Belkin Alexey M., VanBavel Ed, Bakker Erik N. T. P. Activation of extracellular transglutaminase 2 by mechanical force in the arterial wall Journal of vascular research 2013;50 (5):383-395 [PubMed]
  • Tuna Bilge Guvenc, Bakker Erik N. T. P., VanBavel Ed Relation between active and passive biomechanics of small mesenteric arteries during remodeling Journal of biomechanics 2013;46 (8):1420-1426 [PubMed]
  • Tuna Bilge Guvenc, Schoorl Marieke J. C., Bakker Erik N. T. P., de Vos Judith, VanBavel Ed Smooth muscle contractile plasticity in rat mesenteric small arteries: sensitivity to specific vasoconstrictors, distension and inflammatory cytokines Journal of vascular research 2013;50 (3):249-262 [PubMed]
  • del Campo Lara, Guvenc Tuna Bilge, Ferrer Mercedes, van Bavel Ed, Bakker Erik N. T. P. Testosterone and β-oestradiol prevent inward remodelling of rat small mesenteric arteries: role of NO and transglutaminase Clinical science (London, England 2013;124 (12):719-728 [PubMed]
  • Samson Thomas, van Buul Jaap D., Kroon Jeffrey, Welch Christopher, Bakker Erik N., Matlung Hanke L., van den Berg Timo K., Sharek Lisa, Doerschuk Claire, Hahn Klaus, Burridge Keith The guanine-nucleotide exchange factor SGEF plays a crucial role in the formation of atherosclerosis PLoS ONE 2013;8 (1):e55202 [PubMed]

2012

  • Guvenc Tuna Bilge, Bakker Erik N. T. P., VanBavel Ed Smooth Muscle Biomechanics and Plasticity: Relevance for Vascular Calibre and Remodelling Basic & clinical pharmacology & toxicology 2012;110 (1):35-41 [PubMed]
  • van den Akker Jeroen, van Weert Angela, Afink Gijs, Bakker Erik N. T. P., van der Pol Edwin, Böing Anita N., Nieuwland Rienk, VanBavel Ed Transglutaminase 2 is secreted from smooth muscle cells by transamidation-dependent microparticle formation Amino acids 2012;42 (2-3):961-973 [PubMed]
  • Matlung Hanke L., Neele Annette E., Groen Harald C., van Gaalen Kim, Guvenc Tuna Bilge, van Weert Angela, de Vos Judith, Wentzel Jolanda J., Hoogenboezem Mark, van Buul Jaap D., VanBavel Ed, Bakker Erik N. T. P. Transglutaminase activity regulates atherosclerotic plaque composition at locations exposed to oscillatory shear stress Atherosclerosis 2012;224 (2):355-362 [PubMed]
  • van den Akker Jeroen, Guvenc Tuna Bilge, Pistea Adrian, Sleutel Arie J. J., Bakker Erik N. T. P., van Bavel Ed Vascular smooth muscle cells remodel collagen matrices by long-distance action and anisotropic interaction Medical & biological engineering & computing 2012;50 (7):701-715 [PubMed]
  • Johnson Kyle B., Petersen-Jones Humphrey, Thompson Janice M., Hitomi Kiyotaka, Itoh Miho, Bakker Erik N. T. P., Johnson Gail V. W., Colak Gozde, Watts Stephanie W. Vena cava and aortic smooth muscle cells express transglutaminases 1 and 4 in addition to transglutaminase 2 American journal of physiology. Heart and circulatory physiology 2012;302 (7):H1355-H1366 [PubMed]

2011

  • Taherzadeh Zhila Hypertension and resistance vessel function and structure. Role of ethnicity and inflammation 2011. 143p. ISBN 9789064644467. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van Bavel E.T.; Co-supervisors: Bakker E. N. T. P., Brewster L. M.)
  • Matlung Hanke L. Inflammation and transglutaminases in vascular remodeling and artherosclerosis 2011. 170p. ISBN 9789053354070. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van Bavel E. T., de Vries C. J. M.; Co-supervisor: Bakker E. N. T. P.)
  • van den Akker H. H. O. Jeroen Role of transglutaminase 2 in vascular remodeling 2011. 185p. ISBN 9789053353899. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van Bavel E. T.; Co-supervisor: Bakker E. N. T. P.)
  • van den Akker Jeroen, VanBavel Ed, van Geel Remon, Matlung Hanke L., Guvenc Tuna Bilge, Janssen George M. C., van Veelen Peter A., Boelens Wilbert C., de Mey Jo G. R., Bakker Erik N. T. P. The redox state of transglutaminase 2 controls arterial remodeling PLoS ONE 2011;6 (8):e23067 [PubMed]
  • van Strien Miriam E., Baron Wia, Bakker Erik N. T. P., Bauer Jan, Bol John G. J. M., Brevé John J. P., Binnekade Rob, van der Laarse Willem J., Drukarch Benjamin, van Dam Anne-Marie Tissue transglutaminase activity is involved in the differentiation of oligodendrocyte precursor cells into myelin-forming oligodendrocytes during CNS remyelination Glia 2011;59 (11):1622-1634 [PubMed]

2010

  • Bonta Peter I., Matlung Hanke L., Vos Mariska, Peters Stephan L. M., Pannekoek Hans, Bakker Erik N. T. P., de Vries Carlie J. M. Nuclear Receptor Nur77 inhibits vascular outward remodeling and reduces macrophage accumulation and matrix metalloproteinase levels Cardiovascular research 2010;87 (3):561-568 [PubMed]
  • Matlung Hanke L., VanBavel Ed, van den Akker Jeroen, de Vries Carlie J. M., Bakker Erik N. T. P. Role of transglutaminases in cuff-induced atherosclerotic lesion formation in femoral arteries of ApoE3 Leiden mice Atherosclerosis 2010;213 (1):77-84 [PubMed]
  • van den Akker Jeroen, Schoorl Marieke J. C., Bakker Erik N. T. P., VanBavel Ed Small Artery Remodeling: Current Concepts and Questions Journal of vascular research 2010;47 (3):183-202 [PubMed]
  • Taherzadeh Zhila, VanBavel Ed, de Vos Judith, Matlung Hanke L., van Montfrans Gert, Brewster Lizzy M., Seghers Leonard, Quax Paul H. A., Bakker Erik N. T. P. Strain-dependent susceptibility for hypertension in mice resides in the natural killer gene complex American journal of physiology. Heart and circulatory physiology 2010;298 (4):H1273-H1282 [PubMed]

2009

  • Matlung Hanke L., Groen Harald C., de Vos Judith, van Walsum Theo, van der Lugt Aad, Niessen Wiro J., Wentzel Jolanda J., VanBavel Ed, Bakker Erik N. T. P. Calcification Locates to Transglutaminases in Advanced Human Atherosclerotic Lesions American journal of pathology 2009;175 (4):1374-1379 [PubMed]
  • Matlung Hanke L., Bakker Erik Ntp, VanBavel Ed Shear Stress, Reactive Oxygen Species, and Arterial Structure and Function Antioxidants & redox signaling 2009;11 (7):1699-1709 [PubMed]

2008

  • VanBavel Ed, Bakker Erik N. T. P. A vascular bone collector: arterial calcification requires tissue-type transglutaminase Circulation research 2008;102 (5):507-509 [PubMed]
  • Bakker Erik N. T. P., Matlung Hanke L., Bonta Peter, de Vries Carlie J., van Rooijen Nico, VanBavel Ed Blood flow-dependent arterial remodelling is facilitated by inflammation but directed by vascular tone Cardiovascular research 2008;78 (2):341-348 [PubMed]
  • van den Akker Jeroen, Pistea Adrian, Bakker Erik N. T. P., VanBavel Ed Decomposition cross-correlation for analysis of collagen matrix deformation by single smooth muscle cells Medical & biological engineering & computing 2008;46 (5):443-450 [PubMed]
  • van den Akker Jeroen, Pistea Adrian, Bakker Erik N. T. P., VanBavel Ed Decomposition cross-correlation for analysis of collagen matrix deformation by single smooth muscle cells (vol 46, pg 443, 2008) Medical & biological engineering & computing 2008;46 (5):517
  • Pistea Adrian Inward remodeling of small arteries - role of transglutaminases 2008. 155p. ISBN 9789090227009. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van Bavel E. T.; Co-supervisor: Bakker N. T. P.)
  • Pries Axel R., Mulvany Michael J., Bakker Erik N. T. P. MBEC special issue on microcirculation "engineering principles of vascular networks" Medical & biological engineering & computing 2008;46 (5):407-409 [PubMed]
  • Pistea Adrian, Bakker Erik N. T. P., Spaan Jos A. E., Hardeman Max R., van Rooijen Nico, VanBavel Ed Small artery remodeling and erythrocyte deformability in L-NAME-induced hypertension: Role of transglutaminases Journal of vascular research 2008;45 (1):10-18 [PubMed]
  • Bakker Erik N. T. P., Pistea Adrian, VanBavel Ed Transglutaminases in vascular biology: relevance for vascular remodeling and atherosclerosis Journal of vascular research 2008;45 (4):271-278 [PubMed]

2007

  • Csiszar Anna, Labinskyy Nazar, Smith Kira E., Rivera Aracelie, Bakker Erik N. T. P., Jo Hanjoong, Gardner Jason, Orosz Zsuzsanna, Ungvari Zoltan Downregulation of bone morphogenetic protein 4 expression in coronary arterial endothelial cells: role of shear stress and the cAMP/protein kinase A pathway Arteriosclerosis, thrombosis, and vascular biology 2007;27 (4):776-782 [PubMed]

2006

  • Sorop Oana, Bakker Erik N. T. P., Pistea Adrian, Spaan Jos A. E., VanBavel Ed Calcium channel blockade prevents pressure-dependent inward remodeling in isolated subendocardial resistance vessels American journal of physiology. Heart and circulatory physiology 2006;291 (3):H1236-H1245 [PubMed]
  • Bakker Erik N. T. P., Pistea Adrian, Spaan Jos A. E., Rolf Titia, de Vries Carlie J., van Rooijen Nico, Candi Eleonara, VanBavel Ed Flow-dependent remodeling of small arteries in mice deficient for tissue-type transglutaminase: possible compensation by macrophage-derived factor XIII Circulation research 2006;99 (1):86-92 [PubMed]
  • VanBavel Ed, Bakker Erik N. T. P., Pistea Adrian, Sorop Oana, Spaan Jos A. E. Mechanics of microvascular remodeling Clinical hemorheology and microcirculation 2006;34 (1-2):35-41 [PubMed]
  • de Waard Vivian, Arkenbout E. Karin, Vos Mariska, Mocking Astrid I. M., Niessen Hans W. M., Stooker Wim, de Mol Bas A. J. M., Quax Paul H. A., Bakker Erik N. T. P., VanBavel Ed, Pannekoek Hans, de Vries Carlie J. M. TR3 nuclear orphan receptor prevents cyclic stretch-induced proliferation of venous smooth muscle cells American journal of pathology 2006;168 (6):2027-2035 [PubMed]

2005

  • Pistea Adrian, Bakker Erik N. T. P., Spaan Jos A. E., VanBavel Ed Flow inhibits inward remodeling in cannulated porcine small coronary arteries American journal of physiology. Heart and circulatory physiology 2005;289 (6):H2632-H2640 [PubMed]
  • Bakker Erik N. T. P., Buus Carsten L., Spaan Jos A. E., Perree Jop, Ganga Anuradha, Rolf Titia M., Sorop Oana, Bramsen Linda H., Mulvany Michael J., VanBavel Ed Small artery remodeling depends on tissue-type transglutaminase Circulation research 2005;96 (1):119-126 [PubMed]

2004

  • Bakker Erik N. T. P., Buus Carsten L., VanBavel Ed, Mulvany Michael J. Activation of resistance arteries with endothelin-1: From vasoconstriction to functional adaptation and remodeling Journal of vascular research 2004;41 (2):174-182 [PubMed]
  • Buus C. L., Kristensen H. B., Bakker E. N. T. P., Eskildsen-Helmond Y. E. G., Mulvany M. J. Force-independent expression of c-fos mRNA by endothelin-1 in rat intact small mesenteric arteries Acta physiologica Scandinavica 2004;181 (1):1-11 [PubMed]
  • Bakker Erik N. T. P., Sorop Oana, Spaan Jos A. E., VanBavel Ed Remodeling of resistance arteries in organoid culture is modulated by pressure and pressure pulsation and depends on vasomotion American journal of physiology. Heart and circulatory physiology 2004;286 (6):H2052-H2056 [PubMed]

2003

  • Bakker E. N. T. P., Versluis J. P., Sipkema P., VanTeeffelen J. W. G. E., Rolf T. M., Spaan J. A. E., VanBavel E. Differential structural adaptation to haemodynamics along single rat cremaster arterioles Journal of physiology 2003;548 (2):549-555 [PubMed]

2002

  • Bakker Erik N. T. P., van der Meulen Esther T., van den Berg Bernard M., Everts Vincent, Spaan Jos A. E., VanBavel Ed Inward remodeling follows chronic vasoconstriction in isolated resistance arteries Journal of vascular research 2002;39 (1):12-20 [PubMed]

2001

  • Bakker E. N., Balt J. C., Pfaffendorf M., Spaan J. A., VanBavel E. Vasomotor effects of arg-gly-asp (RGD) peptides are limited and not related to endothelium-derived hyperpolarizing factor-mediated relaxation in rat mesenteric arteries Clinical and experimental pharmacology & physiology 2001;28 (11):873-876 [PubMed]

2000

  • Organoid culture of cannulated rat resistance arteries: effect of serum factors on vasoactivity and remodeling American journal of physiology. Heart and circulatory physiology 2000;278 (4):H1233-H1240 [PubMed]

1999

  • Kerkhof C. J., Bakker E. N., Sipkema P. Role of cytochrome P-450 4A in oxygen sensing and NO production in rat cremaster resistance arteries American journal of physiology 1999;277 (4 Part 2):H1546-H1552 [PubMed]
  • Signal transduction in spontaneous myogenic tone in isolated arterioles from rat skeletal muscle Cardiovascular research 1999;41 (1):229-236 [PubMed]

1998

  • Permissive effect of nitric oxide in arachidonic acid induced dilation in isolated rat arterioles Cardiovascular research 1998;38 (3):782-787 [PubMed]

1997

  • Bakker E. N., Sipkema P. Components of acetylcholine-induced dilation in isolated rat arterioles American journal of physiology 1997;273 (4 Part 2):H1848-H1853 [PubMed]
  • Endothelin-1-induced constriction inhibits nitric-oxide-mediated dilation in isolated rat resistance arteries Journal of vascular research 1997;34 (6):418-424 [PubMed]

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