P.J. Bosma PhD publications

2021

• Shi Xiaoxia, Aronson Sem J., ten Bloemendaal Lysbeth, Duijst Suzanne, Bakker Robert S., de Waart Dirk R., Bortolussi Giulia, Collaud Fanny, Oude Elferink Ronald P., Muro Andrés F., Mingozzi Federico, Ronzitti Giuseppe, Bosma Piter J. Efficacy of AAV8-hUGT1A1 with Rapamycin in neonatal, suckling, and juvenile rats to model treatment in pediatric CNs patients Molecular therapy. Methods & clinical development 2021;20:287-297
• Bosma Piter J., Wits Marius, Oude-Elferink Ronald P. J. Gene therapy for progressive familial intrahepatic cholestasis: Current progress and future prospects International journal of molecular sciences 2021;22 (1):1-13 [PubMed]

2020

• Moradi Sharif, Torabi Parisa, Mohebbi Saeed, Amjadian Sara, Bosma Piter, Faridbod Farnoush, Khoddami Vahid, Hosseini Morteza, Babashah Sadegh, Ghotbaddini Maryam, Rasti Arezoo, Shekari Faezeh, Sadeghi-Abandansari Hamid, Kiani Jafar, Shamsara Mehdi, Kazemi-Ashtiani Mohammad, Gholami Samira 10th Royan Institute's International Summer School on “Molecular Biomedicine: From Diagnostics to Therapeutics” BioEssays 2020;42 (6) [PubMed]
• Balestra Dario, Scalet Daniela, Ferrarese Mattia, Lombardi Silvia, Ziliotto Nicole, Croes Chrystal C., Petersen Naomi, Bosma Piter, Riccardi Federico, Pagani Franco, Pinotti Mirko, van de Graaf Stan F. J. A compensatory U1snRNA partially rescues FAH splicing and protein expression in a splicing-defective mouse model of tyrosinemia type I International journal of molecular sciences 2020;21 (6) [PubMed]
• Balestra Dario, Ferrarese Mattia, Lombardi Silvia, Ziliotto Nicole, Branchini Alessio, Petersen Naomi, Bosma Piter, Pinotti Mirko, van de Graaf Stan F. J. An exon-specific small nuclear u1 rna (Exspeu1) improves hepatic otc expression in a splicing-defective spf /ash mouse model of ornithine transcarbamylase deficiency International journal of molecular sciences 2020;21 (22):1-9 [PubMed]
• Aronson Sem J., Bakker Robert S., Moenis Sascha, van Dijk Remco, Bortolussi Giulia, Collaud Fanny, Shi Xiaoxia, Duijst Suzanne, ten Bloemendaal Lysbeth, Ronzitti Giuseppe, Muro Andrés F., Mingozzi Federico, Beuers Ulrich, Bosma Piter J. A Quantitative In Vitro Potency Assay for Adeno-Associated Virus Vectors Encoding for the UGT1A1 Transgene Molecular therapy. Methods & clinical development 2020;18:250-258 [PubMed]

2019

• van Dijk Remco Advanced treatment of severe hyperbilirubinemia and cholestasis 2019. 252p. ISBN 9789402813630. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Beuers U. H. W., Oude Elferink R. P. J.; Co-supervisor: Bosma P. J.)
• Shi Xiaoxia, Aronson Sem, Khan Ahmed Sharif, Bosma Piter J. A novel UGT1A1 gene mutation causing severe unconjugated hyperbilirubinemia: A case report BMC pediatrics 2019;19 (1) [PubMed]
• Aronson Sem J., Bakker Robert S., Shi Xiaoxia, Duijst Suzanne, ten Bloemendaal Lysbeth, de Waart Dirk R., Verheij Joanne, Ronzitti Giuseppe, Oude Elferink Ronald P., Beuers Ulrich, Paulusma Coen C., Bosma Piter J. Liver-directed gene therapy results in long-term correction of progressive familial intrahepatic cholestasis type 3 in mice Journal of hepatology 2019;71 (1):153-162 [PubMed]
• Collaud Fanny, Bortolussi Giulia, Guianvarc'h Laurence, Aronson Sem J., Bordet Thierry, Veron Philippe, Charles Severine, Vidal Patrice, Sola Marcelo Simon, Rundwasser Stephanie, Dufour Delphine G., Lacoste Florence, Luc Cyril, Wittenberghe Laetitia v., Martin Samia, le Bec Christine, Bosma Piter J., Muro Andres F., Ronzitti Giuseppe, Hebben Matthias, Mingozzi Federico Preclinical Development of an AAV8-hUGT1A1 Vector for the Treatment of Crigler-Najjar Syndrome Molecular therapy. Methods & clinical development 2019;12:157-174 [PubMed]
• Aronson Sem J., Veron Philippe, Collaud Fanny, Hubert Aurélie, Delahais Virginie, Honnet G. raldine, de Knegt Robert J., Junge Norman, Baumann Ulrich, di Giorgio Angelo, D'Antiga Lorenzo, Ginocchio Virginia M., Brunetti-Pierri Nicola, Labrune Philippe, Beuers Ulrich, Bosma Piter J., Mingozzi Federico Prevalence and Relevance of Pre-Existing Anti-Adeno-Associated Virus Immunity in the Context of Gene Therapy for Crigler-Najjar Syndrome Human gene therapy 2019;30 (10):1297-1305 [PubMed]
• Milona Alexandra, Massafra Vittoria, Vos Harmjan, Naik Jyoti, Artigas Natalia, Paterson Helen A. B., Bijsmans Ingrid T. G. W., Willemsen Ellen C. L., Ramos Pittol Jose M., Miguel-Aliaga Irene, Bosma Piter, Burgering Boudewijn M. T., Williamson Catherine, Vernia Santiago, Dhillo Waljit S., van Mil Saskia W. C., Owen Bryn M. Steroidogenic control of liver metabolism through a nuclear receptor-network Molecular metabolism 2019;30:221-229 [PubMed]
• Naik Jyoti, Hau Chi M., Bloemendaal Lysbeth ten, Mok Kam S., Hajji Najat, Wehman Ann M., Meisner Sander, Muncan Vanesa, Paauw Nanne J., de Vries H. E., Nieuwland Rienk, Paulusma Coen C., Bosma Piter J. The P4-ATPase ATP9A is a novel determinant of exosome release PLoS ONE 2019;14 (4) [PubMed]

2018

• Shi Xiaoxia, Ykema Matthew Ryan, Hazenoot Jaco, ten Bloemendaal Lysbeth, Mancini Irene, Odijk Machteld, de Haan Peter, Bosma Piter J. Cre Recombinase Mediates the Removal of Bacterial Backbone to Efficiently Generate rSV40 Molecular therapy. Methods & clinical development 2018;9:225-233 [PubMed]

2017

• van Dijk Remco, Aronson Sem J., de Waart Dirk R., van de Graaf Stan F., Duijst Suzanne, Seppen Jurgen, Oude Elferink Ronald, Beuers Ulrich, Bosma Piter J. Biliverdin Reductase inhibitors did not improve severe unconjugated hyperbilirubinemia in vivo Scientific reports 2017;7 (1):1646 [PubMed]
• Bolier Anne Ruth The role of autotaxin in cholestatic pruritus 2017. 178p. ISBN 9789461827975. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Oude Elferink R. P. J. , Beuers U. H. W.; Co-supervisor: Bosma P. J.)

2016

• de Waart Dirk R., Naik Jyoti, Utsunomiya Karina S., Duijst Suzanne, Ho-Mok Kam, Bolier A. Ruth, Hiralall Johan, Bull Laura N., Bosma Piter J., Oude Elferink Ronald P. J., Paulusma Coen C. ATP11C targets basolateral bile salt transporter proteins in mouse central hepatocytes Hepatology (Baltimore, Md.) 2016;64 (1):161-174 [PubMed]
• Ronzitti Giuseppe, Bortolussi Giulia, van Dijk Remco, Collaud Fanny, Charles Severine, Leborgne Christian, Vidal Patrice, Martin Samia, Gjata Bernard, Sola Marcelo Simon, van Wittenberghe Laetitia, Vignaud Alban, Veron Philippe, Bosma Piter J., Muro Andres F., Mingozzi Federico A translationally optimized AAV-UGT1A1 vector drives safe and long-lasting correction of Crigler-Najjar syndrome Molecular therapy. Methods & clinical development 2016;3:16049 [PubMed]
• Jorns C., Nowak G., Nemeth A., Zemack H., Mörk L.-M., Johansson H., Gramignoli R., Watanabe M., Karadagi A., Alheim M., Hauzenberger D., van Dijk R., Bosma P. J., Ebbesen F., Szakos A., Fischler B., Strom S., Ellis E., Ericzon B.-G. De Novo Donor-Specific HLA Antibody Formation in Two Patients With Crigler-Najjar Syndrome Type I Following Human Hepatocyte Transplantation With Partial Hepatectomy Preconditioning American journal of transplantation 2016;16 (3):1021-1030 [PubMed]
• Bolier Ruth, Tolenaars Dagmar, Kremer Andreas E., Saris Job, Parés Albert, Verheij Joanne, Bosma Piter J., Beuers Ulrich, Oude Elferink Ronald P. J. Enteroendocrine cells are a potential source of serum autotaxin in men BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2016;1862 (4):696-704 [PubMed]

2015

• Naik Jyoti, de Waart Dirk R., Utsunomiya Karina, Duijst Suzanne, Mok Kam Ho, Oude Elferink Ronald P. J., Bosma Piter J., Paulusma Coen C. ATP8B1 and ATP11C: Two Lipid Flippases Important for Hepatocyte Function Digestive diseases (Basel, Switzerland) 2015;33 (3):314-318 [PubMed]
• van Dijk Remco, Kremer Andreas E., Smit Wouter, van den Elzen Bram, van Gulik Thomas, Gouma Dirk, Lameris Johan S., Bikker Hennie, Enemuo Valentine, Stokkers Pieter C. F., Feist Mark, Bosma Piter, Jansen Peter L. M., Beuers Ulrich Characterization and treatment of persistent hepatocellular secretory failure Liver international 2015;35 (4):1478-1488 [PubMed]
• van Dijk Remco, Mayayo-Peralta Isabel, Aronson Sem J., Kattentidt-Mouravieva Anja A., van der Mark Vincent A., de Knegt Rob, Oruc Nevin, Beuers Ulrich, Bosma Piter J. Disruption of HNF1α binding site causes inherited severe unconjugated hyperbilirubinemia Journal of hepatology 2015;63 (6):1525-1529 [PubMed]
• van Dijk Remco, Beuers Ulrich, Bosma Piter J. Gene replacement therapy for genetic hepatocellular jaundice Clinical reviews in allergy & immunology 2015;48 (2-3):243-253 [PubMed]
• Aronson Sem J., Beuers Ulrich, Bosma Piter J. Progress and challenges in gene therapy for Crigler-Najjar syndrome Expert opinion on orphan drugs 2015;3 (12):1387-1396

2014

• Montenegro-Miranda P. S., Pichard V., Aubert D., ten Bloemendaal L., Duijst S., de Waart D. R., Ferry N., Bosma P. J. In the rat liver, Adenoviral gene transfer efficiency is comparable to AAV Gene therapy 2014;21 (2):168-174 [PubMed]

2013

• Montenegro-Miranda Paula S., Pañeda Astrid, ten Bloemendaal Lysbeth, Duijst Suzanne, de Waart Dirk R., Aseguinolaza Gloria Gonzalez, Bosma Piter J. Adeno-associated viral vector serotype 5 poorly transduces liver in rat models PLoS ONE 2013;8 (12):e82597 [PubMed]
• Sokolović Aleksandar, Rodriguez-Ortigosa Carlos M., Bloemendaal Lysbeth Ten, Oude Elferink Ronald P. J., Prieto Jesús, Bosma Piter J. Insulin-like growth factor 1 enhances bile-duct proliferation and fibrosis in Abcb4(-/-) mice BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2013;1832 (6):697-704 [PubMed]
• Sokolović Aleksandar Pathogenesis and reversal of liver fibrosis: effects of genes and environment 2013. 125p. ISBN 9789461916235. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Oude Elferink R. P. J.; Co-supervisor: Bosma P. J.)
• van Dijk Remco, Montenegro-Miranda Paula S., Riviere Christel, Schilderink Ronald, ten Bloemendaal Lysbeth, van Gorp Jacqueline, Duijst Suzanne, de Waart Dirk R., Beuers Ulrich, Haisma Hidde J., Bosma Piter J. Polyinosinic acid blocks adeno-associated virus macrophage endocytosis in vitro and enhances adeno-associated virus liver-directed gene therapy in vivo Human gene therapy 2013;24 (9):807-813 [PubMed]

2012

• Seppen Jurgen, Bosma Piter Bilirubin, the Gold Within Circulation 2012;126 (22):2547-2549 [PubMed]
• Montenegro-Miranda Paula S., Sneitz Nina, de Waart D. Rudi, ten Bloemendaal Lysbeth, Duijst Suzanne, de Knegt Robert J., Beuers Ulrich, Finel Moshe, Bosma Piter J. Ezetimibe: A biomarker for efficacy of liver directed UGT1A1 gene therapy for inherited hyperbilirubinemia BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2012;1822 (8):1223-1229 [PubMed]
• Montenegro Miranda Paula S. Gene therapy with adeno-associated viral vectors for inherited hyperbilirubinemia. Towards a clinical trial for Crigler-Najjar syndrome 2012. 197p. ISBN 9789090266633. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Oude Elferink R. P. J.; Co-supervisor: Bosma P. J.)
• Sokolović Aleksandar, Montenegro-Miranda Paula S., de Waart Dirk Rudi, Cappai Radha M. N., Duijst Suzanne, Sokolović Milka, Bosma Piter J. Overexpression of insulin like growth factor binding protein 5 reduces liver fibrosis in chronic cholangiopathy BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2012;1822 (6):996-1003 [PubMed]

2011

• van Geer Michael A. Adenovirus targeting for gene therapy of pancreatic cancer 2011. 173p. ISBN 9789490371623. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Oude Elferink R. P. J.; Co-supervisor: Bosma P. J.)
• Montenegro-Miranda Paula, ten Bloemendaal Lysbeth, Kunne Cindy, de Waart Dirk R., Bosma Piter J. Mycophenolate Mofetil Impairs Transduction of Single-Stranded Adeno-Associated Viral Vectors Human gene therapy 2011;22 (5):605-612 [PubMed]

2010

• van Geer Michael A., Brevoord Daniel, Kuhlmann Koert F. D., Bakker Conny T., Mizuguchi Hiroyuki, Wesseling John G., ten Kate Fibo J., Gouma Dirk J., Oude Elferink Ronald P. J., Bosma Piter J. A fiber modified adenovirus vector that targets to the EphrinA2 receptor reveals enhanced gene transfer to ex vivo pancreatic cancer International journal of oncology 2010;36 (1):233-244 [PubMed]
• Sneitz Nina, Bakker Conny T., de Knegt Robert J., Halley Dicky J. J., Finel Moshe, Bosma Piter J. Crigler-Najjar syndrome in The Netherlands: Identification of four novel UGT1A1 alleles, genotype-phenotype correlation, and functional analysis of 10 missense mutants Human mutation 2010;31 (1):52-59 [PubMed]
• Sokolovic Aleksandar, Sokolovic Milka, Boers Willem, Oude Elferink Ronald P. J., Bosma Piter J. Insulin-like growth factor binding protein 5 enhances survival of LX2 human hepatic stellate cells Fibrogenesis & tissue repair 2010;3 (3):1-13 [PubMed]

2009

• van Geer Michael A., Bakker Conny T., Koizumi Naoya, Mizuguchi Hiroyuki, Wesseling John G., Oude Elferink Ronald P. J., Bosma Piter J. Ephrin A2 receptor targeting does not increase adenoviral pancreatic cancer transduction in vivo World journal of gastroenterology 2009;15 (22):2754-2762 [PubMed]
• van Geer Michael A., Kuhlmann Koert F. D., Bakker Conny T., ten Kate Fibo J. W., Oude Elferink Ronald P. J., Bosma Piter J. Ex-vivo evaluation of gene therapy vectors in human pancreatic (cancer) tissue slices World journal of gastroenterology 2009;15 (11):1359-1366 [PubMed]
• Kuhlmann K. F. D., van Geer M. A., Bakker C. T., Dekker J. E. M., Havenga M. J. E., Elferink R. P. J. Oude, Gouma D. J., Bosma P. J., Wesseling J. G. Fiber-chimeric adenoviruses expressing fibers from serotype 16 and 50 improve gene transfer to human pancreatic adenocarcinoma Cancer gene therapy 2009;16 (7):585-597 [PubMed]
• Miranda Paula S. Montenegro, Bosma Piter J. Towards Liver-Directed Gene Therapy for Crigler-Najjar Syndrome Current gene therapy 2009;9 (2):72-82 [PubMed]

2007

• Marsman Willem A., Wesseling John G., El Bouch Abelkarim, Bosma Piter J., van Lanschot J. Jan B. Adenoviral serotypes in gene therapy for esophageal carcinoma Journal of surgical research 2007;140 (1):50-54 [PubMed]

2006

• Seppen Jurgen, Bakker Conny, de Jong Berry, Kunne Cindy, van den Oever Karin, Vandenberghe Kristin, de Waart Rudi, Twisk Jaap, Bosma Piter Adeno-associated virus vector serotypes mediate sustained correction of bilirubin UDP glucuronosyltransferase deficiency in rats Molecular therapy 2006;13 (6):1085-1092 [PubMed]
• Marsman W. A. Barrett's battle gene therapy and diagnostic endoscopy 2006. 219p. ISBN 9789090212821. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van Lanschot J. J. B.; Co-supervisors: Bosma P. J., Bergman J. J. G. H. M.)
• Lie-A-Ling Michael, Bakker Conny T., Deurholt Tanja, Hoekstra Ruurdtje, Wesseling John G., Afford Simon C., Bosma Piter J. Selection of tumour specific promoters for adenoviral gene therapy of cholangiocarcinoma Journal of hepatology 2006;44 (1):126-133 [PubMed]
• Boers Willem, Aarrass Saida, Linthorst Chris, Pinzani Massimo, Elferink Ronald Oude, Bosma Piter Transcriptional profiling reveals novel markers of liver fibrogenesis: gremlin and insulin-like growth factor-binding proteins Journal of biological chemistry 2006;281 (24):16289-16295 [PubMed]

2005

• Lie-A-Ling M., Bakker C. T., Wesseling J. G., Bosma P. J. AdEasy-based cloning system to generate tropism expanded replicating adenoviruses expressing transgenes late in the viral life cycle Gene therapy 2005;12 (17):1347-1352 [PubMed]
• Marsman Willem A., Buskens Christianne J., Wesseling John G., van Lanschot J. Jan B., Bosma Piter J. Gene therapy for barrett's esophagus: adenoviral gene transfer in different intestinal models Cancer gene therapy 2005;12 (9):778-786 [PubMed]
• Lie-A-Ling M. Gene therapy for cholangiocarcinoma 2005. 152p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Oude Elferink R. P. J.; Co-supervisor: Bosma P. J.)
• Buskens Christianne J., Marsman Willem A., Bosma Piter J., van Lanschot J. Jan B. The current state of cancer gene therapy and its application in esophageal carcinoma Digestive surgery 2005;22 (4):222-233 [PubMed]

2004

• Koshy Abraham, Bosma Piter J., Oude-Elferink Ronald P. J. Crigler-Najjar syndrome type 1 associated with combined 1070A-->G, Q357R and (TA)7 mutation in Kuwaiti Bedouin families indicate a founder effect in Arabs Journal of clinical gastroenterology 2004;38 (5):465-467 [PubMed]
• Marsman Willem A., Buskens Christianne J., Wesseling John G., Offerhaus G. Johan A., Bergman Jacques J. G. H. M., Tytgat Guido N. J., van Lanschot J. Jan B., Bosma Piter J. Gene therapy for esophageal carcinoma: the use of an explant model to test adenoviral vectors ex vivo Cancer gene therapy 2004;11 (4):289-296 [PubMed]
• Marsman Willem A., Birjmohun Rakesh S., van Rees Bastiaan P., Caspers Eric, Johan G., Offerhaus A., Bosma Piter J., Jan J., van Lanschot B. Loss of heterozygosity and immunohistochemistry of adenocarcinomas of the esophagus and gastric cardia Clinical cancer research 2004;10 (24):8479-8485 [PubMed]
• Buskens C. J. The development of new treatment strategies for oesophageal cancer 2004. 304p. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van Lanschot J. J. B., ten Kate F. J. W.; Co-supervisor: Bosma P. J.)

2003

• Buskens Christianne J., Marsman Willem A., Wesseling John G., Offerhaus G. Johan A., Yamamoto Masato, Curiel David T., Bosma Piter J., van Lanschot J. Jan B. A genetically retargeted adenoviral vector enhances viral transduction in esophageal carcinoma cell lines and primary cultured esophageal resection specimens Annals of surgery 2003;238 (6):815-824 [PubMed]
• Medina Juan F., Recalde Sergio, Prieto Jesús, Lecanda Jon, Saez Elena, Funk Colin D., Vecino Paola, van Roon Marian A., Ottenhoff Roelof, Bosma Piter J., Bakker Conny T., Elferink Ronald P. J. Oude Anion exchanger 2 is essential for spermiogenesis in mice Proceedings of the National Academy of Sciences of the United States of America 2003;100 (26):15847-15852 [PubMed]
• Rutjes Saskia A., Bosma Piter J., Rohn Jennifer L., Noteborn Mathieu H. M., Wesseling John G. Induction of insolubility by herpes simplex virus VP22 precludes intercellular trafficking of N-terminal Apoptin-VP22 fusion proteins Journal of molecular medicine (Berlin, Germany) 2003;81 (9):558-565 [PubMed]
• Bosma Piter Jabik Inherited disorders of bilirubin metabolism Journal of hepatology 2003;38 (1):107-117 [PubMed]
• Wesseling J. G., Lie-A-Ling M., Havenga M. J., Bosma P. J. Tergeting cancer with viral vectorsin: Anonymous Falk Workshop 132B. Dordrecht: Kluwer Academic Publishers; 2003. p. 171-181
• Bosma P. The association of elevated serum bilirubin levels and coronary heart disease - Reply Journal of hepatology 2003;39 (5):882
• Bosma Piter J., van der Meer Irene M., Bakker Conny T., Hofman Albert, Paul-Abrahamse Marianne, Witteman Jacqueline C. UGT1A1*28 allele and coronary heart disease: The Rotterdam study Clinical chemistry 2003;49 (7):1180-1181 [PubMed]

2002

• Buskens Christianne J., van Rees Bastiaan P., Sivula Anna, Reitsma Johannes B., Haglund Caj, Bosma Piter J., Offerhaus G. Johan A., van Lanschot J. Jan B., Ristimäki Ari Prognostic significance of elevated cyclooxygenase 2 expression in patients with adenocarcinoma of the esophagus Gastroenterology 2002;122 (7):1800-1807 [PubMed]

2001

• Persico M., Persico E., Bakker C. T., Rigato I., Amoroso A., Torella R., Bosma P. J., Tiribelli C., Ostrow J. D. Hepatic uptake of organic anions affects the plasma bilirubin level in subjects with Gilbert's syndrome mutations in UGT1A1 Hepatology (Baltimore, Md.) 2001;33 (3):627-632 [PubMed]
• Wesseling J. G., Bosma P. J., Krasnykh V., Kashentseva E. A., Blackwell J. L., Reynolds P. N., Li H., Parameshwar M., Vickers S. M., Jaffee E. M., Huibregtse K., Curiel D. T., Dmitriev I. Improved gene transfer efficiency to primary and established human pancreatic carcinoma target cells via epidermal growth factor receptor and integrin-targeted adenoviral vectors Gene therapy 2001;8 (13):969-976 [PubMed]
• Wesseling J. G., Yamamoto M., Adachi Y., Bosma P. J., van Wijland M., Blackwell J. L., Li H., Reynolds P. N., Dmitriev I., Vickers S. M., Huibregtse K., Curiel D. T. Midkine and cyclooxygenase-2 promoters are promising for adenoviral vector gene delivery of pancreatic carcinoma Cancer gene therapy 2001;8 (12):990-996 [PubMed]
• Jacquemin E., de Vree J. M., Cresteil D., Sokal E. M., Sturm E., Dumont M., Scheffer G. L., Paul M., Burdelski M., Bosma P. J., Bernard O., Hadchouel M., Elferink R. P. The wide spectrum of multidrug resistance 3 deficiency: from neonatal cholestasis to cirrhosis of adulthood Gastroenterology 2001;120 (6):1448-1458 [PubMed]

2000

• de Vree J. M., Ottenhoff R., Bosma P. J., Smith A. J., Aten J., Oude Elferink R. P. Correction of liver disease by hepatocyte transplantation in a mouse model of progressive familial intrahepatic cholestasis Gastroenterology 2000;119 (6):1720-1730 [PubMed]
• Paulusma C. C., Kothe M. J., Bakker C. T., Bosma P. J., van Bokhoven I., van Marle J., Bolder U., Tytgat G. N., Oude Elferink R. P. Zonal down-regulation and redistribution of the multidrug resistance protein 2 during bile duct ligation in rat liver Hepatology (Baltimore, Md.) 2000;31 (3):684-693 [PubMed]

1998

• Tada K., Roy-Chowdhury N., Prasad V., Kim B. H., Manchikalapudi P., Fox I. J., van Duijvendijk P., Bosma P. J., Roy-Chowdhury J. Long-term amelioration of bilirubin glucuronidation defect in Gunn rats by transplanting genetically modified immortalized autologous hepatocytes Cell transplantation 1998;7 (6):607-616 [PubMed]
• Tada K., Chowdhury N. R., Neufeld D., Bosma P. J., Heard M., Prasad V. R., Chowdhury J. R. Long-term reduction of serum bilirubin levels in Gunn rats by retroviral gene transfer in vivo Liver transplantation and surgery 1998;4 (1):78-88 [PubMed]
• de Vree J. M., Jacquemin E., Sturm E., Cresteil D., Bosma P. J., Aten J., Deleuze J. F., Desrochers M., Burdelski M., Bernard O., Oude Elferink R. P., Hadchouel M. Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis Proceedings of the National Academy of Sciences of the United States of America 1998;95 (1):282-287 [PubMed]
• Gantla S., Bakker C. T., Deocharan B., Thummala N. R., Zweiner J., Sinaasappel M., Roy Chowdhury J., Bosma P. J., Roy Chowdhury N. Splice-site mutations: a novel genetic mechanism of Crigler-Najjar syndrome type 1 American journal of human genetics 1998;62 (3):585-592 [PubMed]

1997

• Paulusma C. C., Kool M., Bosma P. J., Scheffer G. L., ter Borg F., Scheper R. J., Tytgat G. N., Borst P., Baas F., Oude Elferink R. P. A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome Hepatology (Baltimore, Md.) 1997;25 (6):1539-1542 [PubMed]
• Jansen P. L., Bosma P. J., Bakker C., Lems S. P., Slooff M. J., Haagsma E. B. Persistent unconjugated hyperbilirubinemia after liver transplantation due to an abnormal bilirubin UDP-glucuronosyltransferase gene promoter sequence in the donor Journal of hepatology 1997;27 (1):1-5 [PubMed]
• Seppen J., Tada K., Ottenhoff R., Sengupta K., Chowdhury N. R., Chowdhury J. R., Bosma P. J., Oude Elferink R. P. Transplantation of Gunn rats with autologous fibroblasts expressing bilirubin UDP-glucuronosyltransferase: correction of genetic deficiency and tumor formation Human gene therapy 1997;8 (1):27-36 [PubMed]

1996

• Seppen J., Steenken E., Lindhout D., Bosma P. J., Elferink R. P. A mutation which disrupts the hydrophobic core of the signal peptide of bilirubin UDP-glucuronosyltransferase, an endoplasmic reticulum membrane protein, causes Crigler-Najjar type II FEBS letters 1996;390 (3):294-298 [PubMed]
• Seppen J., Tada K., Hellwig S., Bakker C. T., Prasad V. R., Roy Chowdhury N., Roy Chowdhury J., Bosma P. J., Oude Elferink R. P. Bilirubin glucuronidation by intact Gunn rat fibroblasts expressing bilirubin UDP-glucuronosyltransferase Biochemical journal 1996;314 ( Pt 2):477-483 [PubMed]
• Kim B. H., Takahashi M., Tada K., Bosma P. J., Roy-Chowdhury J., Roy-Chowdhury N. Cell and gene therapy for inherited deficiency of bilirubin glucuronidation Journal of perinatology 1996;16 (3 Part 2):S67-S72 [PubMed]
• Paulusma C. C., Bosma P. J., Zaman G. J., Bakker C. T., Otter M., Scheffer G. L., Scheper R. J., Borst P., Oude Elferink R. P. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene Science 1996;271 (5252):1126-1128 [PubMed]
• Vítek L., Bosma P., de Boer Anita, Jirsa M., Brodanová M., Kotal P. První prípad Criglerova-Najjarova syndromu v Ceské republice Casopis lekaru ceskych 1996;135 (4):114-116 [PubMed]
• Arts J., Grimbergen J., Bosma P. J., Rahmsdorf H. J., Kooistra T. Role of c-Jun and proximal phorbol 12-myristate-13-acetate-(PMA)-responsive elements in the regulation of basal and PMA-stimulated plasminogen-activator inhibitor-1 gene expression in HepG2 European Journal of Biochemistry / FEBS 1996;241 (2):393-402 [PubMed]

1995

• Bosma P., Chowdhury J. R., Jansen P. H. Genetic inheritance of Gilbert's syndrome Lancet 1995;346 (8970):314-315 [PubMed]
• Jansen P. L., Bosma P. J., Chowdhury J. R. Molecular biology of bilirubin metabolism Progress in liver diseases 1995;13:125-150 [PubMed]
• Bosma P. J., Chowdhury J. R., Bakker C., Gantla S., de Boer Anita, Oostra B. A., Lindhout D., Tytgat G. N., Jansen P. L., Oude Elferink R. P. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome New England journal of medicine 1995;333 (18):1171-1175 [PubMed]

1994

• Bosma P. J., Seppen J., Goldhoorn B., Bakker C., Oude Elferink R. P., Chowdhury J. R., Chowdhury N. R., Jansen P. L. Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man Journal of biological chemistry 1994;269 (27):17960-17964 [PubMed]
• Seppen J., Bosma P. J., Goldhoorn B. G., Bakker C. T., Chowdhury J. R., Chowdhury N. R., Jansen P. L., Oude Elferink R. P. Discrimination between Crigler-Najjar type I and II by expression of mutant bilirubin uridine diphosphate-glucuronosyltransferase Journal of clinical investigation 1994;94 (6):2385-2391 [PubMed]
• Bosma P. J., Seppen J., Goldhoorn B., Bakker C., Elferink R. P.J.O., Chowdhury J. R., Chowdhury N. R., Jansen P. L.M. Erratum: Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man (Journal of Biological Chemistry (1994) 269 (17960-17964)) Journal of biological chemistry 1994;269 (41):25942

1993

• Bosma P. J., Goldhoorn B., Oude Elferink R. P., Sinaasappel M., Oostra B. A., Jansen P. L. A mutation in bilirubin uridine 5'-diphosphate-glucuronosyltransferase isoform 1 causing Crigler-Najjar syndrome type II Gastroenterology 1993;105 (1):216-220 [PubMed]
• van Es H. H., Bout A., Liu J., Anderson L., Duncan A. M., Bosma P., Oude Elferink R., Jansen P. L., Chowdhury J. R., Schurr E. Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37 Cytogenetics and cell genetics 1993;63 (2):114-116 [PubMed]

1992

• Bosma P. J., Chowdhury J. R., Huang T. J., Lahiri P., Elferink R. P., van Es H. H., Lederstein M., Whitington P. F., Jansen P. L., Chowdhury N. R. Mechanisms of inherited deficiencies of multiple UDP-glucuronosyltransferase isoforms in two patients with Crigler-Najjar syndrome, type I FASEB journal 1992;6 (10):2859-2863 [PubMed]
• Bosma P. J., Chowdhury N. R., Goldhoorn B. G., Hofker M. H., Oude Elferink R. P., Jansen P. L., Chowdhury J. R. Sequence of exons and the flanking regions of human bilirubin-UDP-glucuronosyltransferase gene complex and identification of a genetic mutation in a patient with Crigler-Najjar syndrome, type I Hepatology (Baltimore, Md.) 1992;15 (5):941-947 [PubMed]

1991

• Bosma P. J., Kooistra T. Different induction of two plasminogen activator inhibitor 1 mRNA species by phorbol ester in human hepatoma cells Journal of biological chemistry 1991;266 (27):17845-17849 [PubMed]
• Bosma P. J., Kooistra T., Siemieniak D. R., Slightom J. L. Further characterization of the 5'-flanking DNA of the gene encoding human plasminogen activator inhibitor-1 Gene 1991;100:261-266 [PubMed]
• Kooistra T., Bosma P. J., Toet K., Cohen L. H., Griffioen M., van den Berg E., le Clercq L., van Hinsbergh V. W. Role of protein kinase C and cyclic adenosine monophosphate in the regulation of tissue-type plasminogen activator, plasminogen activator inhibitor-1, and platelet-derived growth factor mRNA levels in human endothelial cells. Possible involvement of proto-oncogenes c-jun and c-fos Arteriosclerosis and thrombosis 1991;11 (4):1042-1052 [PubMed]

1990

• Kooistra T., Bosma P. J., Jespersen J., Kluft C. Studies on the mechanism of action of oral contraceptives with regard to fibrinolytic variables American journal of obstetrics and gynecology 1990;163 (1 Part 2):404-413 [PubMed]

1989

• Kooistra T., Bosma P. J., Töns H. A., van den Berg A. P., Meyer P., Princen H. M. Plasminogen activator inhibitor 1: biosynthesis and mRNA level are increased by insulin in cultured human hepatocytes Thrombosis and haemostasis 1989;62 (2):723-728 [PubMed]

1988

• Bosma P. J., Rijken D. C., Nieuwenhuizen W. Binding of tissue-type plasminogen activator to fibrinogen fragments European Journal of Biochemistry / FEBS 1988;172 (2):399-404 [PubMed]
• Bosma P. J., van den Berg E. A., Kooistra T., Siemieniak D. R., Slightom J. L. Human plasminogen activator inhibitor-1 gene. Promoter and structural gene nucleotide sequences Journal of biological chemistry 1988;263 (19):9129-9141 [PubMed]

1987

• Bron S., Bosma P., van Belkum M., Luxen E. Stability function in the Bacillus subtilis plasmid pTA 1060 Plasmid 1987;18 (1):8-15 [PubMed]