PhD A. Baartscheer publications

2019

• Uthman Laween, Nederlof Rianne, Eerbeek Otto, Baartscheer Antonius, Schumacher Cees, Buchholtz Ninée, Hollmann Markus W, Coronel Ruben, Weber Nina C, Zuurbier Coert J Delayed ischaemic contracture onset by empagliflozin associates with NHE1 inhibition and is dependent on insulin in isolated mouse hearts Cardiovascular research 2019;115 (10):1533-1545 [PubMed]

2018

• Uthman Laween, Baartscheer Antonius, Bleijlevens Boris, Schumacher Cees A., Fiolet Jan W. T., Koeman Anneke, Jancev Milena, Hollmann Markus W., Weber Nina C., Coronel Ruben, Zuurbier Coert J. Class effects of SGLT2 inhibitors in mouse cardiomyocytes and hearts: inhibition of Na+/H+ exchanger, lowering of cytosolic Na+ and vasodilation Diabetologia 2018;61 (3):722-726 [PubMed]
• Uthman Laween, Baartscheer Antonius, Schumacher Cees A, Fiolet Jan W T, Kuschma Marius C, Hollmann Markus W, Coronel Ruben, Weber Nina C, Zuurbier Coert J Direct Cardiac Actions of Sodium Glucose Cotransporter 2 Inhibitors Target Pathogenic Mechanisms Underlying Heart Failure in Diabetic Patients Frontiers in physiology 2018;9:1575 [PubMed]
• Rivaud Mathilde R., Baartscheer Antonius, Verkerk Arie O., Beekman Leander, Rajamani Sridharan, Belardinelli Luiz, Bezzina Connie R., Remme Carol Ann Enhanced late sodium current underlies pro-arrhythmic intracellular sodium and calcium dysregulation in murine sodium channelopathy International journal of cardiology 2018;263:54-62 [PubMed]
• Baartscheer Antonius, Veldkamp Marieke W. Is IGF-1 a useful inhibitor of Na+/H+-exchanger activity? Acta physiologica (Oxford, England) 2018;224 (2) [PubMed]
• Veldkamp Marieke W., Geuzebroek Guillaume S. C., Baartscheer Antonius, Verkerk Arie O., Schumacher Cees A., Suarez Gedeon G., Berger Wouter R., Casini Simona, van Amersfoorth Shirley C. M., Scholman Koen T., Driessen Antoine H. G., Belterman Charly N. W., van Ginneken Antoni C. G., de Groot Joris R., de Bakker Jacques M. T., Remme Carol Ann, Boukens Bas J., Coronel Ruben Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel Nature communications 2018;9 (1) [PubMed]
• Medzikovic Lejla, van Roomen Cindy, Baartscheer Antonius, van Loenen Pieter B, de Vos Judith, Bakker Erik N T P, Koenis Duco S, Damanafshan Amin, Creemers Esther E, Arkenbout E Karin, de Vries Carlie J M, de Waard Vivian Nur77 protects against adverse cardiac remodelling by limiting neuropeptide Y signalling in the sympathoadrenal-cardiac axis Cardiovascular research 2018;114 (12):1617-1628 [PubMed]
• van den Hoogenhof Maarten M. G., Beqqali Abdelaziz, Amin Ahmad S., van der Made Ingeborg, Aufiero Simona, Khan Mohsin A. F., Schumacher Cees A., Jansweijer Joeri A., van Spaendonck-Zwarts Karin Y., Remme Carol Ann, Backs Johannes, Verkerk Arie O., Baartscheer Antonius, Pinto Yigal M., Creemers Esther E. RBM20 Mutations Induce an Arrhythmogenic Dilated Cardiomyopathy Related to Disturbed Calcium Handling Circulation 2018;138 (13):1330-1342 [PubMed]

2017

• Baartscheer Antonius, Schumacher Cees A., Wüst Rob C. I., Fiolet Jan W. T., Stienen Ger J. M., Coronel Ruben, Zuurbier Coert J. Empagliflozin decreases myocardial cytoplasmic Na+ through inhibition of the cardiac Na+/H+ exchanger in rats and rabbits Diabetologia 2017;60 (3):568-573 [PubMed]

2016

• Baartscheer Antonius, Veldkamp Marieke W., Coronel Ruben Letter by Baartscheer et al Regarding Editorial, "Matter of Fat: Are Lipids Antiarrhythmic?" Circulation. Arrhythmia and electrophysiology 2016;9 (3):e003933 [PubMed]
• Nederlof Rianne, Gürel-Gurevin Ebru, Eerbeek Otto, Xie Chaoqin, Deijs G. Sjoerd, Konkel Moritz, Hu Jun, Weber Nina C., Schumacher Cees A., Baartscheer Antonius, Mik Egbert G., Hollmann Markus W., Akar Fadi G., Zuurbier Coert J. Reducing mitochondrial bound hexokinase II mediates transition from non-injurious into injurious ischemia/reperfusion of the intact heart Journal of physiology and biochemistry 2016;73 (3):323-333 [PubMed]
• Keul Petra, van Borren Marcel M. G. J., Ghanem Alexander, Müller Frank Ulrich, Baartscheer Antonius, Verkerk Arie O., Stümpel Frank, Schulte Jan Sebastian, Hamdani Nazha, Linke Wolfgang A., van Loenen Pieter, Matus Marek, Schmitz Wilhelm, Stypmann Jörg, Tiemann Klaus, Ravesloot Jan-Hindrik, Alewijnse Astrid E., Hermann Sven, Spijkers Léon J. A., Hiller Karl-Heinz, Herr Deron, Heusch Gerd, Schäfers Michael, Peters Stephan L. M., Chun Jerold, Levkau Bodo Sphingosine-1-Phosphate Receptor 1 Regulates Cardiac Function by Modulating Ca2+ Sensitivity and Na+/H+ Exchange and Mediates Protection by Ischemic Preconditioning Journal of the American Heart Association 2016;5 (5):e003393 [PubMed]

2015

• Baartscheer Antonius, Schumacher Cees A., Wekker Vincent, Verkerk Arie O., Veldkamp Marieke W., van Oort Ralph J., Elzenaar Ies, Ottenhoff Roelof, van Roomen Cindy, Aerts Hans, Coronel Ruben Dyscholesterolemia Protects Against Ischemia-Induced Ventricular Arrhythmias Circulation. Arrhythmia and electrophysiology 2015;8 (6):1481-1490 [PubMed]
• Bakermans Adrianus J., Abdurrachim Desiree, van Nierop Bastiaan J., Koeman Anneke, van der Kroon Inge, Baartscheer Antonius, Schumacher Cees A., Strijkers Gustav J., Houten Sander M., Zuurbier Coert J., Nicolay Klaas, Prompers Jeanine J. In vivo mouse myocardial P-31 MRS using three-dimensional image-selected in vivo spectroscopy (3D ISIS): technical considerations and biochemical validations NMR in biomedicine 2015;28 (10):1218-1227 [PubMed]
• Medzikovic Lejla, Schumacher Cees A., Verkerk Arie O., van Deel Elza D., Wolswinkel Rianne, van der Made Ingeborg, Bleeker Natascha, Cakici Daniella, van den Hoogenhof Maarten M. G., Meggouh Farid, Creemers Esther E., Remme Carol Ann, Baartscheer Antonius, de Winter Robbert J., de Vries Carlie J. M., Arkenbout E. Karin, de Waard Vivian Orphan nuclear receptor Nur77 affects cardiomyocyte calcium homeostasis and adverse cardiac remodelling Scientific reports 2015;5:15404 [PubMed]

2013

• Zumhagen Sven, Veldkamp Marieke W., Stallmeyer Birgit, Baartscheer Antonius, Eckardt Lars, Paul Matthias, Remme Carol Ann, Bhuiyan Zahurul A., Bezzina Connie R., Schulze-Bahr Eric A heterozygous deletion mutation in the cardiac sodium channel gene SCN5A with loss- and gain-of-function characteristics manifests as isolated conduction disease, without signs of Brugada or long QT syndrome PLoS ONE 2013;8 (6):e67963 [PubMed]
• Birket Matthew J., Casini Simona, Kosmidis Georgios, Elliott David A., Gerencser Akos A., Baartscheer Antonius, Schumacher Cees, Mastroberardino Pier G., Elefanty Andrew G., Stanley Ed G., Mummery Christine L. PGC-1α and Reactive Oxygen Species Regulate Human Embryonic Stem Cell-Derived Cardiomyocyte Function Stem cell reports 2013;1 (6):560-574 [PubMed]

2012

• den Ruijter Hester M., Verkerk Arie O., Schumacher Cees A., Houten Sander M., Belterman Charly N. W., Baartscheer Antonius, Brouwer Ingeborg A., van Bilsen Marc, de Roos Baukje, Coronel Ruben A Diet Rich in Unsaturated Fatty Acids Prevents Progression Toward Heart Failure in a Rabbit Model of Pressure and Volume Overload Circulation. Heart failure 2012;5 (3):376-384 [PubMed]
• van Borren Marcel M. G. J., den Ruijter Hester M., Baartscheer Antonius, Ravesloot Jan H., Coronel Ruben, Verkerk Arie O. Dietary omega-3 polyunsaturated fatty acids suppress NHE-1 upregulation in a rabbit model of volume- and pressure-overload Frontiers in physiology 2012;3:UNSP 76 [PubMed]

2011

• Boukens Bastiaan J., Baartscheer Antonius, Higa Satoshi Arrhythmogenic pulmonary vein myocardium in heart failure Clinical and experimental pharmacology & physiology 2011;38 (10):654-655 [PubMed]
• Verkerk Arie O., Baartscheer Antonius, de Groot Joris R., Wilders Ronald, Coronel Ruben Etiology-dependency of ionic remodeling in cardiomyopathic rabbits International journal of cardiology 2011;148 (2):154-160 [PubMed]
• Baartscheer Antonius, Schumacher Cees A., Coronel Ruben, Fiolet Jan W. T. The driving force of the Na+/Ca2+-exchanger during metabolic inhibition Frontiers in physiology 2011;2:10 [PubMed]

2008

• den Ruijter Hester M., Berecki Géza, Verkerk Arie O., Bakker Diane, Baartscheer Antonius, Schumacher Cees A., Belterman Charly N. W., de Jonge Nicolaas, Fiolet Jan W. T., Brouwer Ingeborg A., Coronel Ruben Acute administration of fish oil inhibits triggered activity in isolated myocytes from rabbits and patients with heart failure Circulation 2008;117 (4):536-544 [PubMed]
• Baartscheer A., Hardziyenka M., Schumacher C. A., Belterman C. N. W., van Borren M. M. G. J., Verkerk A. O., Coronel R., Fiolet J. W. T. Chronic inhibition of the Na(+)/H(+)- exchanger causes regression of hypertrophy, heart failure, and ionic and electrophysiological remodelling British journal of pharmacology 2008;154 (6):1266-1275 [PubMed]
• den Ruijter Hester M., Berecki Geza, Verkerk Arie O., Bakker Diane, Baartscheer Antonius, Schumacher Cees A., Belterman Charly N. W., Fiolet Jan W. T., Coronel Ruben, de Jonge Nicolaas, Brouwer Ingeborg A. Response to letter regarding article "Acute Administration of Fish Oil Inhibits Triggered Activity in Isolated Myocytes From Rabbits and Patients With Heart Failure" Circulation 2008;118 (3):E70
• Baartscheer Antonius, van Borren Marcel M. G. J. Sodium ion transporters as new therapeutic targets in heart failure Cardiovascular & hematological agents in medicinal chemistry 2008;6 (4):229-236 [PubMed]

2007

• Berecki Géza, den Ruijter Hester M., Verkerk Arie O., Schumacher Cees A., Baartscheer Antonius, Bakker Diane, Boukens Bastiaan J., van Ginneken Antoni C. G., Fiolet Jan W. T., Opthof Tobias, Coronel Ruben Dietary fish oil reduces the incidence of triggered arrhythmias in pig ventricular myocytes Heart rhythm 2007;4 (11):1452-1460 [PubMed]

2006

• Baartscheer Antonius Chronic inhibition of na(+)/h(+)-exchanger in the heart Current vascular pharmacology 2006;4 (1):23-29 [PubMed]
• van Borren Marcel M. G. J., Zegers Jan G., Baartscheer Antonius, Ravesloot Jan H. Contribution of NHE-1 to cell length shortening of normal and failing rabbit cardiac myocytes Journal of molecular and cellular cardiology 2006;41 (4):706-715 [PubMed]
• Verkerk Arie O., van Ginneken Antoni C. G., Berecki Géza, den Ruijter Hester M., Schumacher Cees A., Veldkamp Marieke W., Baartscheer Antonius, Casini Simona, Opthof Tobias, Hovenier Robert, Fiolet Jan W. T., Zock Peter L., Coronel Ruben Incorporated sarcolemmal fish oil fatty acids shorten pig ventricular action potentials Cardiovascular research 2006;70 (3):509-520 [PubMed]
• Wiegerinck Rob F., Verkerk Arie O., Belterman Charly N., van Veen Toon A. B., Baartscheer Antonius, Opthof Tobias, Wilders Ronald, de Bakker Jacques M. T., Coronel Ruben Larger cell size in rabbits with heart failure increases myocardial conduction velocity and QRS duration Circulation 2006;113 (6):806-813 [PubMed]

2005

• Baartscheer Antonius, Schumacher Cees A., van Borren Marcel M. G. J., Belterman Charly N. W., Coronel Ruben, Opthof Tobias, Fiolet Jan W. T. Chronic inhibition of Na+/H+-exchanger attenuates cardiac hypertrophy and prevents cellular remodeling in heart failure Cardiovascular research 2005;65 (1):83-92 [PubMed]

2004

• van Borren Marcel M. G. J., Baartscheer Antonius, Wilders Ronald, Ravesloot Jan H. NHE-1 and NBC during pseudo-ischemia/reperfusion in rabbit ventricular myocytes Journal of molecular and cellular cardiology 2004;37 (2):567-577 [PubMed]

2003

• Wilders R., Veldkamp M. W., Baartscheer A., Zegers J. G., Bezzina C. R., Wilde A. A. M. Bradycardia in LQT3 patients: Insights from 0D modelsin: A. Anonymous, editors. Engineering in Medicine and Biology Society, 2003. S.l.: s.n.; 2003. p. 32-35, ISBN 9780780377899
• Veldkamp Marieke W., Wilders Ronald, Baartscheer Antonius, Zegers Jan G., Bezzina Connie R., Wilde Arthur A. M. Contribution of sodium channel mutations to bradycardia and sinus node dysfunction in LQT3 families Circulation research 2003;92 (9):976-983 [PubMed]
• Balt Jippe C., Belterman Charly N. W., Mathy Marie-Jeanne, Nap Alexander, Baartscheer Anton, Pfaffendorf Martin, van Zwieten Pieter A. Decreased facilitation by angiotensin II of noradrenergic neurotransmission in isolated mesenteric artery of rabbits with chronic heart failure Journal of cardiovascular pharmacology 2003;41 (3):356-362 [PubMed]
• Baartscheer A., Schumacher C. A., van Borren M. M. G. J., Belterman C. N. W., Coronel R., Fiolet J. W. T. Increased Na+/H+-exchange activity is the cause of increased [Na+](i) and underlies disturbed calcium handling in the rabbit pressure and volume overload heart failure model Cardiovascular research 2003;57 (4):1015-1024 [PubMed]
• de Groot Joris R., Schumacher Cees A., Verkerk Arie O., Baartscheer Antonius, Fiolet Jan W. T., Coronel Ruben Intrinsic heterogeneity in repolarization is increased in isolated failing rabbit cardiomyocytes during simulated ischemia Cardiovascular research 2003;59 (3):705-714 [PubMed]
• Baartscheer A., Schumacher C. A., Belterman C. N. W., Coronel R., Fiolet J. W. T. [Na+](i) and the driving force of the Na+/Ca2+-exchanger in heart failure Cardiovascular research 2003;57 (4):986-995 [PubMed]
• Baartscheer Antonius, Schumacher Cees A., Belterman Charly N. W., Coronel Ruben, Fiolet Jan W. T. SR calcium handling and calcium after-transients in a rabbit model of heart failure Cardiovascular research 2003;58 (1):99-108 [PubMed]

2002

• Verkerk A. O., Tan H. L., Baartscheer A., Ravesloot J. H. Limited role of Ca2+-activated CI- current in early afterdepolarisations Netherlands heart journal 2002;10 (12):506-511
• van Borren Marcel M. G. J., Verkerk Arie O., Vanharanta Sakari K., Baartscheer Antonius, Coronel Ruben, Ravesloot Jan H. Reduced swelling-activated Cl- current densities in hypertrophied ventricular myocytes of rabbits with heart failure Cardiovascular research 2002;53 (4):869-878 [PubMed]

2001

• Baartscheer A. Adenovirus gene transfer of SERCA in heart failure. A promising therapeutic approach ? Cardiovascular research 2001;49 (2):249-252 [PubMed]
• Janse M. J., Vermeulen J. T., Opthof T., Coronel R., Wilms-Schopman F. J., Rademaker H. M., Baartscheer A., Dekker L. R. Arrhythmogenesis in heart failure Journal of cardiovascular electrophysiology 2001;12 (4):496-499 [PubMed]
• Verkerk A. O., Veldkamp M. W., Baartscheer A., Schumacher C. A., Klöpping C., van Ginneken A. C., Ravesloot J. H. Ionic mechanism of delayed afterdepolarizations in ventricular cells isolated from human end-stage failing hearts Circulation 2001;104 (22):2728-2733 [PubMed]
• Veldkamp M. W., Verkerk A. O., van Ginneken A. C., Baartscheer A., Schumacher C., de Jonge N., de Bakker J. M., Opthof T. Norepinephrine induces action potential prolongation and early afterdepolarizations in ventricular myocytes isolated from human end-stage failing hearts European heart journal 2001;22 (11):955-963 [PubMed]
• Coronel R., Baartscheer A., Rademaker J. M. E., Vermeulen J. T., de Bakker J. M. T. The arrhythmogenic substrate in ischemic and non-ischemic cardiomyopathiesin: L. B. Liem, E. Downar, editors. Progress in catheter ablation, clinical application of new mapping and ablation techniques. Boston: Kluwer Academic Publishers; 2001. p. 1-12

2000

• Cellular calcium homeostasis during ischemia; a thermodynamic approach Cardiovascular research 2000;45 (1):100-106 [PubMed]
• SR calcium depletion following reversal of the Na+/Ca2+-exchanger in rat ventricular myocytes Journal of molecular and cellular cardiology 2000;32 (6):1025-1037 [PubMed]
• Two distinct congenital arrhythmias evoked by a multidysfunctional Na(+) channel Circulation research 2000;86 (9):E91-E97 [PubMed]

1998

• Cytoplasmic sodium, calcium and free energy change of the Na+/Ca2+-exchanger in rat ventricular myocytes Journal of molecular and cellular cardiology 1998;30 (11):2437-2447 [PubMed]
• Energy-dependent transport of calcium to the extracellular space during acute ischemia of the rat heart Journal of molecular and cellular cardiology 1998;30 (8):1631-1642 [PubMed]

1997

• Small changes of cytosolic sodium in rat ventricular myocytes measured with SBFI in emission ratio mode Journal of molecular and cellular cardiology 1997;29 (12):3375-3383 [PubMed]

1996

• The origin of increased cytoplasmic calcium upon reversal of the Na+/Ca(2+)-exchanger in isolated rat ventricular myocytes Journal of molecular and cellular cardiology 1996;28 (9):1963-1973 [PubMed]

1995

• Intracellular [Ca2+] and Vo2 after manipulation of the free-energy of the Na+/Ca(2+)-exchanger in isolated rat ventricular myocytes Journal of molecular and cellular cardiology 1995;27 (8):1513-1525 [PubMed]

1993

• Osmotic changes and transsarcolemmal ion transport during total ischaemia of isolated rat ventricular myocytes Basic research in cardiology 1993;88 (5):396-410 [PubMed]

1991

• Transsarcolemmal sodium-calcium exchange and myocardial oxygen consumption in isolated rat ventricular myocytes Journal of molecular and cellular cardiology 1991;23 (6):735-748 [PubMed]

1988

• The cytoplasmic free energy of ATP hydrolysis in isolated rod-shaped rat ventricular myocytes Journal of molecular and cellular cardiology 1988;20 (5):435-441 [PubMed]

1985

• Transmural inhomogeneity of energy metabolism during acute global ischemia in the isolated rat heart: dependence on environmental conditions Journal of molecular and cellular cardiology 1985;17 (1):87-92 [PubMed]

1984

• The change of the free energy of ATP hydrolysis during global ischemia and anoxia in the rat heart. Its possible role in the regulation of transsarcolemmal sodium and potassium gradients Journal of molecular and cellular cardiology 1984;16 (11):1023-1036 [PubMed]

1979

• Evaluation of the creatine kinase MB kit of Boehringer Clinical chemistry 1979;25 (3):496 [PubMed]