B. Distel PhD publications

foto

Publications PhD B. Distel

Position
Associate Professor
Main activities
Education, Research
Specialisation
Biochemistry and molecular biology
Focus of research

In the last ten years my research group has focused on the role of protein ubiquitination in disease. To unravel the function of protein ubiquitination in disease development we use a variety of biochemical, molecular biological and cell-biological techniques including yeast two-hybrid, protein-protein interaction assays and proteomics. In 2005 we discovered a novel type of ubiquitination that targets a cysteine residue in the substrate protein. Since then my group has made other important contributions to the ubiquitin field among which the identification and characterization of the RING E3 ligase involved in the ubiquitination of the peroxisomal import receptor and establishing a novel mechanism of E2 enzyme regulation that involves binding of a co-activator protein. Since 2010 we use our expertise on protein ubiquitination to study the role of this protein modification in Angelman Syndrome, a severe neurological disorder caused by mutations in the UBE3A gene encoding the ubiquitin protein ligase E6AP (collaboration with prof. Elgersma, Erasmus MC). To carry out this work we have established in vitro and cellular ubiquitination assays, including a recently developed system in which we have reconstituted E6AP-dependent target ubiquitination in bacteria. Protein-protein interaction screens have led to the identification of several E6AP-interacting proteins. We are using our battery of in vitro and cellular assays to establish the in vivo function of these E6AP targets and determine their contribution to AS pathology.

 

Amsterdam UMC Research Institutes
AMC departments
All publications

2021

  • Avagliano Trezza Rossella, Punt A. Mattijs, Mientjes Edwin, van den Berg Marlene, Zampeta F. Isabella, de Graaf Ilona J., van der Weegen Yana, Demmers Jeroen A. A., Elgersma Ype, Distel Ben Mono-ubiquitination of Rabphilin 3A by UBE3A serves a non-degradative function Scientific reports 2021;11 (1) [PubMed]

2020

  • Geerts-Haages Amber, Bossuyt Stijn N. V., den Besten Inge, Bruggenwirth Hennie, van der Burgt Ineke, Yntema Helger G., Punt A. Mattijs, Brooks Alice, Elgersma Ype, Distel Ben, Valstar Marlies A novel UBE3A sequence variant identified in eight related individuals with neurodevelopmental delay, results in a phenotype which does not match the clinical criteria of Angelman syndrome Molecular genetics and genomic medicine 2020;8 (11) [PubMed]
  • Zampeta F. Isabella, Sonzogni Monica, Niggl Eva, Lendemeijer Bas, Smeenk Hilde, de Vrij Femke M. S., Kushner Steven A., Distel Ben, Elgersma Ype Conserved UBE3A subcellular distribution between human and mice is facilitated by non-homologous isoforms Human molecular genetics 2020;29 (18):3032-3043 [PubMed]

2019

  • Avagliano Trezza Rossella A matter of perspective: The multifaceted role of UBE3A in Angelman syndrome development 2019. 223p. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Distel B. , Zelcer N.; Co-supervisor: Aerts J. M. F. G.)
  • de Vrij Femke M., Bouwkamp Christian G., Gunhanlar Nilhan, Shpak Guy, Lendemeijer Bas, Baghdadi Maarouf, Gopalakrishna Shreekara, Ghazvini Mehrnaz, Li Tracy M., Quadri Marialuisa, Olgiati Simone, Breedveld Guido J., Coesmans Michiel, Mientjes Edwin, de Wit Ton, Verheijen Frans W., Beverloo H. Berna, Cohen Dan, Kok Rob M., Bakker P. Roberto, Nijburg Aviva, Spijker Annet T., Haffmans P. M. Judith, Hoencamp Erik, Bergink Veerle, Vorstman Jacob A., Wu Timothy, Olde Loohuis Loes M., Amin Najaf, Langen Carolyn D., Hofman Albert, Hoogendijk Witte J., van Duijn Cornelia M., Ikram M. Arfan, Vernooij Meike W., Tiemeier Henning, Uitterlinden André G., Elgersma Ype, Distel Ben, Gribnau Joost, White Tonya, Bonifati Vincenzo, Kushner Steven A. Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia Molecular psychiatry 2019;24:757-771 [PubMed]
  • Avagliano Trezza Rossella, Sonzogni Monica, Bossuyt Stijn N V, Zampeta F Isabella, Punt A Mattijs, van den Berg Marlene, Rotaru Diana C, Koene Linda M C, Munshi Shashini T, Stedehouder Jeffrey, Kros Johan M, Williams Mark, Heussler Helen, de Vrij Femke M S, Mientjes Edwin J, van Woerden Geeske M, Kushner Steven A, Distel Ben, Elgersma Ype Loss of nuclear UBE3A causes electrophysiological and behavioral deficits in mice and is associated with Angelman syndrome Nature neuroscience 2019;22 (8):1235-1247 [PubMed]

2018

  • Avagliano Trezza Rossella, van den Burg Janny, van den Oever Nico, Distel Ben A versatile plasmid system for reconstitution and analysis of mammalian ubiquitination cascades in yeast Microbial cell 2018;5 (3):150-157 [PubMed]
  • Sluimer Jasper, Distel Ben Regulating the human HECT E3 ligases Cellular and molecular life sciences 2018;75 (17):3121-3141 [PubMed]

2017

  • Küry Sébastien, van Woerden Geeske M., Besnard Thomas, Proietti Onori Martina, Latypova Xénia, Towne Meghan C., Cho Megan T., Prescott Trine E., Ploeg Melissa A., Sanders Stephan, Stessman Holly A. F., Pujol Aurora, Distel Ben, Robak Laurie A., Bernstein Jonathan A., Denommé-Pichon Anne-Sophie, Lesca Gaëtan, Sellars Elizabeth A., Berg Jonathan, Carré Wilfrid, Busk Øyvind Løvold, van Bon Bregje W. M., Waugh Jeff L., Deardorff Matthew, Hoganson George E., Bosanko Katherine B., Johnson Diana S., Dabir Tabib, Holla Øystein Lunde, Sarkar Ajoy, Tveten Kristian, de Bellescize Julitta, Braathen Geir J., Terhal Paulien A., Grange Dorothy K., van Haeringen Arie, Lam Christina, Mirzaa Ghayda, Burton Jennifer, Bhoj Elizabeth J., Douglas Jessica, Santani Avni B., Nesbitt Addie I., Helbig Katherine L., Andrews Marisa V., Begtrup Amber, Tang Sha, van Gassen Koen L. I., Juusola Jane, Foss Kimberly, Enns Gregory M., Moog Ute, Hinderhofer Katrin, Paramasivam Nagarajan, Lincoln Sharyn, Kusako Brandon H., Lindenbaum Pierre, Charpentier Eric, Nowak Catherine B., Cherot Elouan, Simonet Thomas, Ruivenkamp Claudia A. L., Hahn Sihoun, Brownstein Catherine A., Xia Fan, Schmitt Sébastien, deb Wallid, Bonneau Dominique, Nizon Mathilde, Quinquis Delphine, Chelly Jamel, Rudolf Gabrielle, Sanlaville Damien, Parent Philippe, Gilbert-Dussardier Brigitte, Toutain Annick, Sutton Vernon R., Thies Jenny, Peart-Vissers Lisenka E. L. M., Boisseau Pierre, Vincent Marie, Grabrucker Andreas M., Dubourg Christèle, Tan Wen-Hann, Verbeek Nienke E., Granzow Martin, Santen Gijs W. E., Shendure Jay, Isidor Bertrand, Pasquier Laurent, Redon Richard, Yang Yaping, State Matthew W., Kleefstra Tjitske, Cogné Benjamin, Petrovski Slavé, Retterer Kyle, Eichler Evan E., Rosenfeld Jill A., Agrawal Pankaj B., Bézieau Stéphane, Odent Sylvie, Elgersma Ype, Mercier Sandra De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability American journal of human genetics 2017;101 (5):768-788 [PubMed]
  • Hakonen Johanna E., Sorrentino Vincenzo, Avagliano Trezza Rossella, de Wissel Marit B., van den Berg Marlene, Bleijlevens Boris, van Ruissen Fred, Distel Ben, Baas Frank, Zelcer Noam, Weterman Marian A. J. LRSAM1-mediated ubiquitylation is disrupted in axonal Charcot-Marie-Tooth disease 2P Human molecular genetics 2017;26 (11):2034-2041 [PubMed]
  • Avula Tejakalyan Role of SH3 and BAR domains in fission yeast 2017. 245p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Aerts J. M. F. G.; Co-supervisors: Hochstenbach F. M. H., Distel B.)
  • Gkourtsa Areti Understanding the role of BAR and SH3 domain-containing proteins in fungi 2017. 243p. ISBN 9789077595886. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Aerts J. M. F. G.; Co-supervisors: Distel B., Hochstenbach F. M. H.)

2016

  • Gkourtsa Areti, van den Burg Janny, Avula Teja, Hochstenbach Frans, Distel Ben Binding of a proline-independent hydrophobic motif by the Candida albicans Rvs167-3 SH3 domain Microbiological research 2016;190:27-36 [PubMed]
  • Nelson Jessica Kristine, Sorrentino Vincenzo, Avagliano Trezza Rossella, Heride Claire, Urbe Sylvie, Distel Ben, Zelcer Noam The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL Circulation research 2016;118 (3):410-419 [PubMed]

2015

  • Tillmann Anna T., Strijbis Karin, Cameron Gary, Radmaneshfar Elahe, Thiel Marco, Munro Carol A., Maccallum Donna M., Distel Ben, Gow Neil A. R., Brown Alistair J. P. Contribution of Fdh3 and Glr1 to Glutathione Redox State, Stress Adaptation and Virulence in Candida albicans PLoS ONE 2015;10 (6):e0126940 [PubMed]
  • Verschueren Erik, Spiess Matthias, Gkourtsa Areti, Avula Teja, Landgraf Christiane, Mancilla Victor Tapia, Huber Aline, Volkmer Rudolf, Winsor Barbara, Serrano Luis, Hochstenbach Frans, Distel Ben Evolution of the SH3 Domain Specificity Landscape in Yeasts PLoS ONE 2015;10 (6):e0129229 [PubMed]
  • Gkourtsa Areti, van den Burg Janny, Strijbis Karin, Avula Teja, Bijvoets Sietske, Timm Dave, Hochstenbach Frans, Distel Ben Identification and characterization of Rvs162/Rvs167-3, a novel N-BAR heterodimer in the human fungal pathogen Candida albicans Eukaryotic cell 2015;14 (2):182-193 [PubMed]
  • Silva-Santos Sara, van Woerden Geeske M., Bruinsma Caroline F., Mientjes Edwin, Jolfaei Mehrnoush Aghadavoud, Distel Ben, Kushner Steven A., Elgersma Ype Ube3a reinstatement identifies distinct developmental windows in a murine Angelman syndrome model Journal of clinical investigation 2015;125 (5):2069-2076 [PubMed]

2013

  • Williams Chris, van den Berg Marlene, Stanley Will A., Wilmanns Matthias, Distel Ben A disulphide bond in the E2 enzyme Pex4p modulates ubiquitin-conjugating activity Scientific reports 2013;3:2212-(6 p.) [PubMed]

2012

  • Strijbis Karin, van den Burg Janny, F Visser Wouter, van den Berg Marlene, Distel Ben Alternative splicing directs dual localization of Candida albicans 6-phosphogluconate dehydrogenase to cytosol and peroxisomes FEMS yeast research 2012;12 (1):61-68 [PubMed]
  • Williams Chris, van den Berg Marlene, Panjikar Santosh, Stanley Will A., Distel Ben, Wilmanns Matthias Insights into ubiquitin-conjugating enzyme/co-activator interactions from the structure of the Pex4p:Pex22p complex EMBO journal 2012;31 (2):391-402 [PubMed]

2011

  • Williams Chris P., Schueller Nicole, Thompson Colin A., van den Berg Marlene, van Haren Simon D., Erdmann Ralf, Bond Charles S., Distel Ben, Schliebs Wolfgang, Wilmanns Matthias, Stanley Will A. The Peroxisomal Targeting Signal 1 in sterol carrier protein 2 is autonomous and essential for receptor recognition BMC biochemistry 2011;12 (1):12-(1-8) [PubMed]

2010

  • Strijbis Karin, van Roermund Carlo W., van den Burg Janny, van den Berg Marlene, Hardy Guy P. M., Wanders Ronald J., Distel Ben Contributions of Carnitine Acetyltransferases to Intracellular Acetyl Unit Transport in Candida albicans Journal of biological chemistry 2010;285 (32):24335-24346 [PubMed]
  • Strijbis Karin, Vaz Frédéric M., Distel Ben Enzymology of the Carnitine Biosynthesis Pathway IUBMB life 2010;62 (5):357-362 [PubMed]
  • Strijbis Karin, Distel Ben Intracellular Acetyl Unit Transport in Fungal Carbon Metabolism Eukaryotic cell 2010;9 (12):1809-1815 [PubMed]

2009

  • Strijbis Karin Compartmentalization of metabolic pathways in Candida albicans: a matter of transport 2009. 187p. ISBN 9789081406215. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Aerts J. M. F. G.; Co-supervisor: Distel B.)
  • Strijbis Karin, van Roermund Carlo W. T., Hardy Guy P., van den Burg Janny, Bloem Karien, de Haan Jolanda, van Vlies Naomi, Wanders Ronald J. A., Vaz Frédéric M., Distel Ben Identification and characterization of a complete carnitine biosynthesis pathway in Candida albicans FASEB journal 2009;23 (8):2349-2359 [PubMed]
  • Williams Chris, Distel Ben Protein Quality Control in Peroxisomes: Ubiquitination of the Peroxisomal Targeting Signal Receptorsin: Ralph A. Bradshaw, Edward A. Dennis, editors. Handbook of Cell Signaling : Vol. 3. 2nd edition. Oxford: Academic Press; 2009. p. 2489-2497

2008

  • Strijbis Karin, van Roermund Carlo W. T., Visser Wouter F., Mol Els C., van den Burg Janny, Maccallum Donna M., Odds Frank C., Paramonova Ekaterina, Krom Bastiaan P., Distel Ben Carnitine-dependent transport of acetyl coenzyme A in Candida albicans is essential for growth on nonfermentable carbon sources and contributes to biofilm formation Eukaryotic cell 2008;7 (4):610-618 [PubMed]
  • Williams Chris, van den Berg Marlene, Geers Erica, Distel Ben Pex10p functions as an E-3 ligase for the Ubc4p-dependent ubiquitination of Pex5p Biochemical and biophysical research communications 2008;374 (4):620-624 [PubMed]
  • Piekarska Katarzyna, Hardy Guy, Mol Els, van den Burg Janny, Strijbis Karin, van Roermund Carlo, van den Berg Marlene, Distel Ben The activity of the glyoxylate cycle in peroxisomes of Candida albicans depends on a functional beta-oxidation pathway: evidence for reduced metabolite transport across the peroxisomal membrane Microbiology (Reading, England) 2008;154 (Part 10):3061-3072 [PubMed]

2007

  • Williams Chris, van den Berg Marlene, Sprenger Richard R., Distel Ben A conserved cysteine is essential for Pex4p-dependent ubiquitination of the peroxisomal import receptor Pex5p Journal of biological chemistry 2007;282 (31):22534-22543 [PubMed]
  • Williams C.P. Pex5p and ubiquitin: regulation of the PTS1 protein import receptor 2007. 168p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Aerts J. M. F. G.; Co-supervisor: Distel Ben)
  • Dekker Nick, van Rijssel Jos, Distel Ben, Hochstenbach Frans Role of the alpha-glucanase Agn2p in ascus-wall endolysis following sporulation in fission yeast Yeast (Chichester, England) 2007;24 (4):279-288 [PubMed]
  • Vos Alina, Dekker Nick, Distel Ben, Leunissen Jack A. M., Hochstenbach Frans Role of the synthase domain of Ags1p in cell wall alpha-glucan biosynthesis in fission yeast Journal of biological chemistry 2007;282 (26):18969-18979 [PubMed]
  • Piekarska Katarzyna The role of peroxisomal metabolism in virulence of Candida albicans 2007. 164p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Aerts Johannes M. F. G.; Co-supervisor: Distel Ben)

2006

  • Piekarska Katarzyna, Mol Els, van den Berg Marlene, Hardy Guy, van den Burg Janny, van Roermund Carlo, MacCallum Donna, Odds Frank, Distel Ben Peroxisomal fatty acid beta-oxidation is not essential for virulence of Candida albicans Eukaryotic cell 2006;5 (11):1847-1856 [PubMed]
  • Williams Chris, Distel Ben Pex13p: docking or cargo handling protein? BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 2006;1763 (12):1585-1591 [PubMed]
  • Distel Ben, Kragt Astrid Purification of yeast peroxisomes Methods in molecular biology (Clifton, N.J.) 2006;313:21-26 [PubMed]
  • Distel B., Kragt A. Purification of yeast peroxisomesin: W. Xiao, editors. Yeast protocols: Second edition. Totowa. New Jersey: Humana Press; 2006. p. 21-26
  • Kragt A., Benne R., Distel B. Ubiquitin: a new player in the peroxisome fieldin: R. J. Mayer, A. Ciechanover, M. Rechsteiner, editors. Protein degradation. Cell biology of the ubiquitin-proteasome system. Weinheim: Wiley-VCH; 2006. p. 1-20, ISBN 9783527314355

2005

  • Kragt Astrid, Voorn-Brouwer Tineke, van den Berg Marlene, Distel Ben Endoplasmic reticulum-directed Pex3p routes to peroxisomes and restores peroxisome formation in a Saccharomyces cerevisiae pex3Delta strain Journal of biological chemistry 2005;280 (40):34350-34357 [PubMed]
  • Williams Chris, van den Berg Marlene, Distel Ben Saccharomyces cerevisiae Pex14p contains two independent Pex5p binding sites, which are both essential for PTS1 protein import FEBS letters 2005;579 (16):3416-3420 [PubMed]
  • Kragt A. Studies on the role of the Er and ubuquitin in peroxisomes biogenesis 2005. 168p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Aerts J. M. F. G.; Co-supervisor: Distel B.)
  • Kragt Astrid, Voorn-Brouwer Tineke, van den Berg Marlene, Distel Ben The Saccharomyces cerevisiae peroxisomal import receptor Pex5p is monoubiquitinated in wild type cells Journal of biological chemistry 2005;280 (9):7867-7874 [PubMed]

2003

  • Geuze Hans J., Murk Jean Luc, Stroobants An K., Griffith Janice M., Kleijmeer Monique J., Koster Abraham J., Verkleij Arie J., Distel Ben, Tabak Henk F. Involvement of the endoplasmic reticulum in peroxisome formation Molecular biology of the cell 2003;14 (7):2900-2907 [PubMed]
  • Klein A. T. J. Pex5p, a guide for import of proteins into peroxisomes 2003. 167p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Tabak H. F.; Co-supervisor: Distel B.)

2002

  • Klein Andre T. J., van den Berg Marlene, Bottger Gina, Tabak Henk F., Distel Ben Saccharomyces cerevisiae acyl-CoA oxidase follows a novel, non-PTS1, import pathway into peroxisomes that is dependent on Pex5p Journal of biological chemistry 2002;277 (28):25011-25019 [PubMed]
  • Douangamath Alice, Filipp Fabian V., Klein André T. J., Barnett Phil, Zou Peijian, Voorn-Brouwer Tineke, Vega M. Cristina, Mayans Olga M., Sattler Michael, Distel Ben, Wilmanns Matthias Topography for independent binding of alpha-helical and PPII-helical ligands to a peroxisomal SH3 domain Molecular cell 2002;10 (5):1007-1017 [PubMed]

2001

  • Voorn-Brouwer T., Kragt A., Tabak H. F., Distel B. Peroxisomal membrane proteins are properly targeted to peroxisomes in the absence of COPI- and COPII-mediated vesicular transport Journal of cell science 2001;114 (Part 11):2199-2204 [PubMed]
  • Klein A. T., Barnett P., Bottger G., Konings D., Tabak H. F., Distel B. Recognition of peroxisomal targeting signal type 1 by the import receptor Pex5p Journal of biological chemistry 2001;276 (18):15034-15041 [PubMed]

2000

  • Kal A. J., Hettema E. H., van den Berg M., Koerkamp M. G., van Ijlst L., Distel B., Tabak H. F. In silicio search for genes encoding peroxisomal proteins in Saccharomyces cerevisiae Cell biochemistry and biophysics 2000;32 Spring:1-8 [PubMed]
  • Rehling P., Skaletz-Rorowski A., Girzalsky W., Voorn-Brouwer T., Franse M. M., Distel B., Veenhuis M., Kunau W. H., Erdmann R. Pex8p, an intraperoxisomal peroxin of Saccharomyces cerevisiae required for protein transport into peroxisomes binds the PTS1 receptor pex5p Journal of biological chemistry 2000;275 (5):3593-3602 [PubMed]
  • Hettema E. H., Girzalsky W., van den Berg M., Erdmann R., Distel B. Saccharomyces cerevisiae pex3p and pex19p are required for proper localization and stability of peroxisomal membrane proteins EMBO journal 2000;19 (2):223-233 [PubMed]
  • Bottger G., Barnett P., Klein A. T., Kragt A., Tabak H. F., Distel B. Saccharomyces cerevisiae PTS1 receptor Pex5p interacts with the SH3 domain of the peroxisomal membrane protein Pex13p in an unconventional, non-PXXP-related manner Molecular biology of the cell 2000;11 (11):3963-3976 [PubMed]
  • Barnett P., Bottger G., Klein A. T., Tabak H. F., Distel B. The peroxisomal membrane protein Pex13p shows a novel mode of SH3 interaction EMBO journal 2000;19 (23):6382-6391 [PubMed]
  • Distel B., Braakman I., Elgersma Y., Tabak H. F. Transactions at the peroxisomal membrane Sub-cellular biochemistry 2000;34:303-322 [PubMed]

1999

  • Hettema E. H., Distel B., Tabak H. F. Import of proteins into peroxisomes BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1999;1451 (1):17-34 [PubMed]
  • Tabak H. F., Braakman I., Distel B. Peroxisomes: simple in function but complex in maintenance Trends in cell biology 1999;9 (11):447-453 [PubMed]

1998

  • Distel B., Bauer U., Le Borgne R., Hoflack B. Basolateral sorting of the cation-dependent mannose 6-phosphate receptor in Madin-Darby canine kidney cells. Identification of a basolateral determinant unrelated to clathrin-coated pit localization signals Journal of biological chemistry 1998;273 (1):186-193 [PubMed]
  • Brites P., Motley A., Hogenhout E., Hettema E., Wijburg F., Heijmans H. S., Tabak H. F., Distel B., Wanders R. J. Molecular basis of rhizomelic chondrodysplasia punctata type I: high frequency of the Leu-292 stop mutation in 38 patients Journal of inherited metabolic disease 1998;21 (3):306-308 [PubMed]
  • Hettema E. H., Ruigrok C. C., Koerkamp M. G., van den Berg M., Tabak H. F., Distel B., Braakman I. The cytosolic DnaJ-like protein djp1p is involved specifically in peroxisomal protein import Journal of cell biology 1998;142 (2):421-434 [PubMed]

1997

  • Elgersma Y., Kwast L., van den Berg M., Snyder W. B., Distel B., Subramani S., Tabak H. F. Overexpression of Pex15p, a phosphorylated peroxisomal integral membrane protein required for peroxisome assembly in S.cerevisiae, causes proliferation of the endoplasmic reticulum membrane EMBO journal 1997;16 (24):7326-7341 [PubMed]
  • Motley A. M., Hettema E. H., Hogenhout E. M., Brites P., ten Asbroek A. L., Wijburg F. A., Baas F., Heijmans H. S., Tabak H. F., Wanders R. J., Distel B. Rhizomelic chondrodysplasia punctata is a peroxisomal protein targeting disease caused by a non-functional PTS2 receptor Nature genetics 1997;15 (4):377-380 [PubMed]

1996

  • Elgersma Y., Vos A., van den Berg M., van Roermund C. W., van der Sluijs P., Distel B., Tabak H. F. Analysis of the carboxyl-terminal peroxisomal targeting signal 1 in a homologous context in Saccharomyces cerevisiae Journal of biological chemistry 1996;271 (42):26375-26382 [PubMed]
  • Distel B., Erdmann R., Gould S. J., Blobel G., Crane D. I., Cregg J. M., Dodt G., Fujiki Y., Goodman J. M., Just W. W., Kiel J. A., Kunau W. H., Lazarow P. B., Mannaerts G. P., Moser H. W., Osumi T., Rachubinski R. A., Roscher A., Subramani S., Tabak H. F., Tsukamoto T., Valle D., van der Klei I., van Veldhoven P. P., Veenhuis M. A unified nomenclature for peroxisome biogenesis factors Journal of cell biology 1996;135 (1):1-3 [PubMed]
  • Distel B., van der Leij I., Kos W. Peroxisome isolation Methods in molecular biology (Clifton, N.J.) 1996;53:133-138 [PubMed]
  • Hettema E. H., van Roermund C. W., Distel B., van den Berg M., Vilela C., Rodrigues-Pousada C., Wanders R. J., Tabak H. F. The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevisiae EMBO journal 1996;15 (15):3813-3822 [PubMed]
  • Elgersma Y., Kwast L., Klein A., Voorn-Brouwer T., van den Berg M., Metzig B., America T., Tabak H. F., Distel B. The SH3 domain of the Saccharomyces cerevisiae peroxisomal membrane protein Pex13p functions as a docking site for Pex5p, a mobile receptor for the import PTS1-containing proteins Journal of cell biology 1996;135 (1):97-109 [PubMed]

1995

  • Tabak H. F., Elgersma Y., Hettema E., Franse M. M., Voorn-Brouwer T., Distel B. Transport of proteins and metabolites across the impermeable membrane of peroxisomes Cold Spring Harbor symposia on quantitative biology 1995;60:649-655 [PubMed]

1994

  • Motley A., Hettema E., Distel B., Tabak H. Differential protein import deficiencies in human peroxisome assembly disorders Journal of cell biology 1994;125 (4):755-767 [PubMed]

1993

  • Elgersma Y., van den Berg M., Tabak H. F., Distel B. An efficient positive selection procedure for the isolation of peroxisomal import and peroxisome assembly mutants of Saccharomyces cerevisiae Genetics 1993;135 (3):731-740 [PubMed]
  • Einerhand A. W., Kos W. T., Distel B., Tabak H. F. Characterization of a transcriptional control element involved in proliferation of peroxisomes in yeast in response to oleate European Journal of Biochemistry / FEBS 1993;214 (1):323-331 [PubMed]
  • van der Leij I., Franse M. M., Elgersma Y., Distel B., Tabak H. F. PAS10 is a tetratricopeptide-repeat protein that is essential for the import of most matrix proteins into peroxisomes of Saccharomyces cerevisiae Proceedings of the National Academy of Sciences of the United States of America 1993;90 (24):11782-11786 [PubMed]
  • Voorn-Brouwer T., van der Leij I., Hemrika W., Distel B., Tabak H. F. Sequence of the PAS8 gene, the product of which is essential for biogenesis of peroxisomes in Saccharomyces cerevisiae BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1993;1216 (2):325-328 [PubMed]

1992

  • van der Leij I., van den Berg M., Boot R., Franse M., Distel B., Tabak H. F. Isolation of peroxisome assembly mutants from Saccharomyces cerevisiae with different morphologies using a novel positive selection procedure Journal of cell biology 1992;119 (1):153-162 [PubMed]
  • Distel B., Gould S. J., Voorn-Brouwer T., van der Berg M., Tabak H. F., Subramani S. The carboxyl-terminal tripeptide serine-lysine-leucine of firefly luciferase is necessary but not sufficient for peroxisomal import in yeast New biologist 1992;4 (2):157-165 [PubMed]
  • Einerhand A. W., van der Leij I., Kos W. T., Distel B., Tabak H. F. Transcriptional regulation of genes encoding proteins involved in biogenesis of peroxisomes in Saccharomyces cerevisiae Cell biochemistry and function 1992;10 (3):185-191 [PubMed]

1990

  • Gould S. J., Keller G. A., Schneider M., Howell S. H., Garrard L. J., Goodman J. M., Distel B., Tabak H., Subramani S. Peroxisomal protein import is conserved between yeast, plants, insects and mammals EMBO journal 1990;9 (1):85-90 [PubMed]

1989

  • Leyte A., Mertens K., Distel B., Evers R. F., de Keyzer-Nellen M. J., Groenen-van Dooren M. M., de Bruin J., Pannekoek H., van Mourik J. A., Verbeet M. P. Inhibition of human coagulation factor VIII by monoclonal antibodies. Mapping of functional epitopes with the use of recombinant factor VIII fragments Biochemical journal 1989;263 (1):187-194 [PubMed]

1988

  • Distel B., van der Leÿ I., Veenhuis M., Tabak H. F. Alcohol oxidase expressed under nonmethylotrophic conditions is imported, assembled, and enzymatically active in peroxisomes of Hansenula polymorpha Journal of cell biology 1988;107 (5):1669-1675 [PubMed]

1987

  • Distel B., Veenhuis M., Tabak H. F. Import of alcohol oxidase into peroxisomes of Saccharomyces cerevisiae EMBO journal 1987;6 (10):3111-3116 [PubMed]

1985

  • Verweij C. L., de Vries C. J., Distel B., van Zonneveld A. J., van Kessel A. G., van Mourik J. A., Pannekoek H. Construction of cDNA coding for human von Willebrand factor using antibody probes for colony-screening and mapping of the chromosomal gene Nucleic acids research 1985;13 (13):4699-4717 [PubMed]
  • Cohen A., Distel B., van Deursen A., Breure A. M., van Andel J. G. Role of anaerobic spore-forming bacteria in the acidogenesis of glucose: changes induced by discontinuous or low-rate feed supply Antonie van Leeuwenhoek 1985;51 (2):179-192 [PubMed]

1984

  • Roholl P. J., Distel B. A study of the proliferative response of rabbit T cells using the BrdU-Hoechst method Cell and tissue kinetics 1984;17 (3):263-273 [PubMed]
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