C.A. Spek PhD publications

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Publications PhD C.A. Spek

Position
Research Associate
Main activities
Research
Specialisation
Protease activated receptor signaling in pathophysiology
Focus of research
  • Blood coagulation-driven Protease Activated Receptor signaling in pathophysiology.
  • Role of Protease Activated Receptors in pulmonary fibrosis.
  • Relationship between blood coagulation and pancreatic cancer.
  • C/EBPdelta: master regulator of pancreatic cancer progression.

 

2020

  • Hartl Leonie, Duitman Janwillem, Aberson Hella L., Chen Kan, Dijk Frederike, Roelofs Joris J. T. H., Dings Mark P. G., Hooijer Gerrit K. J., Hernanda Pratika Y., Pan Qiunwei, Busch Olivier R., Besselink Marc G. H., Boerman Ton, Peppelenbosch Maikel P., Bijlsma Maarten F., Spek C. Arnold Ccaat/enhancer-binding protein delta (C/ebpδ): A previously unrecognized tumor suppressor that limits the oncogenic potential of pancreatic ductal adenocarcinoma cells Cancers 2020;12 (9):1-21 [PubMed]
  • Tekin Cansu, Aberson Hella L., Bijlsma Maarten F., Spek C. Arnold Early macrophage infiltrates impair pancreatic cancer cell growth by TNF-α secretion BMC cancer 2020;20 (1) [PubMed]
  • Spek C. Arnold, Duitman JanWillem Idiopathic pulmonary fibrosis: do scientists focus on publishing rather than on clinical relevance? European respiratory journal 2020;55 (6) [PubMed]
  • Tekin Cansu, Aberson Hella L., Waasdorp Cynthia, Hooijer Gerrit K. J., de Boer Onno J., Dijk Frederike, Bijlsma Maarten F., Spek C. Arnold Macrophage-secreted MMP9 induces mesenchymal transition in pancreatic cancer cells via PAR1 activation Cellular oncology 2020;43 (6):1161-1174 [PubMed]
  • Slapak Etienne J., Duitman Janwillem, Tekin Cansu, Bijlsma Maarten F., Spek C. Arnold Matrix metalloproteases in pancreatic ductal adenocarcinoma: Key drivers of disease progression? Biology 2020;9 (4) [PubMed]
  • Spek C. Arnold Thrombin-mediated vasculogenic mimicry: important lessons to improve anticoagulant therapy of selected cancer patients Signal Transduction and Targeted Therapy 2020;5 (1) [PubMed]

2019

  • Liu Pengyu, Cao Wanlu, Ma Buyun, Li Meng, Chen Kan, Sideras Kostandinos, Duitman Jan-Willem, Sprengers Dave, Khe Tran T. C., Ijzermans Jan N. M., Biermann Katharina, Verheij Joanne, Arnold Spek C., Kwekkeboom Jaap, Pan Qiuwei, Peppelenbosch Maikel P. Action and clinical significance of CCAAT/enhancer-binding protein delta in hepatocellular carcinoma Carcinogenesis 2019;40 (1):155-163 [PubMed]
  • Duitman JanWillem, van den Ende Tom, Spek C Arnold Immune Checkpoints as Promising Targets for the Treatment of Idiopathic Pulmonary Fibrosis? Journal of clinical medicine 2019;8 (10) [PubMed]
  • Spek C Arnold, Duitman JanWillem Is idiopathic pulmonary fibrosis a cancer-like disease?: Transcriptome analysis to fuel the debate ERJ open research 2019;5 (1) [PubMed]
  • Waasdorp Maaike, Florquin Sandrine, Duitman JanWillem, Spek C. Arnold Pharmacological PAR-1 inhibition reduces blood glucose levels but does not improve kidney function in experimental type 2 diabetic nephropathy FASEB journal 2019;33 (10):10966-10972 [PubMed]
  • Waasdorp Maaike, de Rooij Dennis M., Florquin Sandrine, Duitman JanWillem, Spek C. Arnold Protease-activated receptor-1 contributes to renal injury and interstitial fibrosis during chronic obstructive nephropathy Journal of cellular and molecular medicine 2019;23 (2):1268-1279 [PubMed]
  • Spek C. A., Tekin C., Bijlsma M. F. Protease-activated receptor-1 impedes prostate and intestinal tumor progression in mice: comment Journal of thrombosis and haemostasis 2019;17 (1):235-238 [PubMed]
  • Faria Alessandra V. De S., Akyala Adamu Ishaku, Parikh Kaushal, Brüggemann Lois W., Spek C. Arnold, Cao Wanlu, Bruno Marco J., Bijlsma Maarten F., Fuhler Gwenny M., Peppelenbosch Maikel P. Smoothened-dependent and -independent pathways in mammalian noncanonical Hedgehog signaling Journal of biological chemistry 2019;294 (25):9787-9798 [PubMed]

2018

  • Waasdorp Maaike, Duitman Jan-Willem, Florquin Sandrine, Spek C Arnold Erratum: Protease activated receptor 2 in diabetic nephropathy: a double edged sword American journal of translational research 2018;10 (7):2220 [PubMed]
  • Tekin Cansu, Shi Kun, Daalhuisen Joost B., Brink Marieke S. Ten, Bijlsma Maarten F., Spek C. Arnold PAR1 signaling on tumor cells limits tumor growth by maintaining a mesenchymal phenotype in pancreatic cancer Oncotarget 2018;9 (62):32010-32023 [PubMed]
  • van den Boogaard Florry E., Brands Xanthe, Duitman JanWillem, de Stoppelaar Sacha F., Borensztajn Keren S., Roelofs Joris J. T. H., Hollenberg Morley D., Spek C. Arnold, Schultz Marcus J., van ‘t Veer Cornelis, van der Poll Tom Protease-activated receptor 2 facilitates bacterial dissemination in pneumococcal pneumonia Journal of infectious diseases 2018;217 (9):1462-1471 [PubMed]
  • Waasdorp Maaike Protease-activated receptors in diabetic nephropathy and renal fibrosis 2018. ISBN 9789463800709. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van der Poll T., Florquin S.; Co-supervisors: Spek C. A., Duitman J. W.)
  • Waasdorp Maaike, Duitman JanWillem, Florquin Sandrine, Spek C. Arnold Vorapaxar treatment reduces mesangial expansion in streptozotocin-induced diabetic nephropathy in mice Oncotarget 2018;9 (31):21655-21662 [PubMed]

2017

  • Wilts I. T., Hutten B. A., Meijers J. C. M., Spek C. A., Büller H. R., Kamphuisen P. W. Association between protein C levels and mortality in patients with advanced prostate, lung and pancreatic cancer Thrombosis research 2017;154:1-6 [PubMed]
  • Shi Kun, Damhofer Helene, Daalhuisen Joost, ten Brink Marieke, Richel Dick J., Spek C. Arnold Dabigatran Potentiates Gemcitabine-Induced Growth Inhibition of Pancreatic Cancer in Mice Molecular medicine (Cambridge, Mass.) 2017;23:13-23 [PubMed]
  • Waasdorp Maaike, Duitman Janwillem, Spek C. Arnold Plasmin reduces fibronectin deposition by mesangial cells in a protease-activated receptor-1 independent manner Biochemistry and biophysics reports 2017;10:152-156 [PubMed]
  • Lin Cong, Majoor Christof J., Roelofs Joris J. T. H., de Kruif Martijn D., Horlings Hugo M., Borensztajn Keren, Spek C. Arnold Potential importance of protease activated receptor (PAR)-1 expression in the tumor stroma of non-small-cell lung cancer BMC cancer 2017;17 (1):113 [PubMed]
  • Waasdorp Maaike, Duitman Janwillem, Florquin Sandrine, Spek Arnold C. Protease activated receptor 2 in diabetic nephropathy: a double edged sword American journal of translational research 2017;9 (10):4512-4520 [PubMed]
  • Lin C., Borensztajn K., Spek C. A. Targeting coagulation factor receptors - protease-activated receptors in idiopathic pulmonary fibrosis Journal of thrombosis and haemostasis 2017;15 (4):597-607 [PubMed]

2016

  • Duitman Janwillem, Valls Serón Mercedes, Engelen-Lee Jooyeon, Brouwer Matthijs C., Spek C. Arnold, van de Beek Diederik Detrimental role for CCAAT/enhancer binding protein δ in blood-borne brain infection BMC infectious diseases 2016;16 (1):670 [PubMed]
  • Lin Cong, von der Thüsen Jan, Isermann Berend, Weiler Hartmut, van der Poll Tom, Borensztajn Keren, Spek Chris A. High endogenous activated protein C levels attenuates bleomycin-induced pulmonary fibrosis Journal of cellular and molecular medicine 2016;20 (11):2029-2035 [PubMed]
  • Wilts I T, Hutten B A, Meijers J C, Spek C A, Büller H R, Kamphuisen P W PO-28 - Protein C levels are associated with mortality in patients with advanced cancer Thrombosis research 2016;140 Suppl 1:S186-7 [PubMed]
  • Waasdorp Maaike, Duitman Janwillem, Florquin Sandrine, Spek C. Arnold Protease-activated receptor-1 deficiency protects against streptozotocin-induced diabetic nephropathy in mice Scientific reports 2016;6:33030 [PubMed]

2015

  • Spek C. Arnold, Versteeg Henri H., Borensztajn Keren S. Anticoagulant therapy of cancer patients: Will patient selection increase overall survival? Thrombosis and haemostasis 2015;114 (3):530-536 [PubMed]
  • Shi Kun, Spek C. Arnold Authors' reply-Re: Shi et al. Protease-activated receptor 2 suppresses lymphangiogenesis and subsequent lymph node metastasis in a murine pancreatic cancer model. J Pathol 2014;234: 398-409 Journal of pathology 2015;236 (1):130 [PubMed]
  • Shi Kun Blood coagulation-(in)dependent protease activated receptor signaling in pancreatic cancer 2015. 189p. ISBN 9789462038226. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Richel D. J.; Co-supervisor: Spek C. A.)
  • Valls Serón Mercedes, Duitman Janwillem, Geldhoff Madelijn, Engelen-Lee Jooyeon, Havik Stefan R., Brouwer Matthijs C., van de Beek Diederik, Spek C. Arnold CCAAT/enhancer-binding protein δ (C/EBPδ) aggravates inflammation and bacterial dissemination during pneumococcal meningitis Journal of neuroinflammation 2015;12 (1):88 [PubMed]
  • Lin Cong, von der Thüsen Jan, van der Poll Tom, Borensztajn Keren, Spek C. Arnold Increased Mortality during Bleomycin-induced Pulmonary Fibrosis due to Low Endogenous Activated Protein C Levels American journal of respiratory and critical care medicine 2015;192 (10):1257-1259 [PubMed]
  • Sanjabi Bahram, Dashty Monireh, Özcan Behiye, Akbarkhanzadeh Vishtaseb, Rahimi Mehran, Vinciguerra Manlio, van Rooij Felix, Al-Lahham Saad, Sheedfar Fareeba, van Kooten Theo G., Spek C. Arnold, Rowshani Ajda T., van der Want Johannes, Klaassen Rene, Sijbrands Eric, Peppelenbosch Maikel P., Rezaee Farhad Lipid droplets hypertrophy: a crucial determining factor in insulin regulation by adipocytes Scientific reports 2015;5:8816 [PubMed]
  • Alves Maria M., Fuhler Gwenny M., Queiroz Karla C. S., Scholma Jetse, Goorden Susan, Anink Jasper, Spek C. Arnold, Hoogeveen-Westerveld Marianne, Bruno Marco J., Nellist Mark, Elgersma Ype, Aronica Eleonora, Peppelenbosch Maikel P. PAK2 is an effector of TSC1/2 signaling independent of mTOR and a potential therapeutic target for Tuberous Sclerosis Complex Scientific reports 2015;5:14534 [PubMed]
  • Lin Cong, von der Thüsen Jan, Daalhuisen Joost, ten Brink Marieke, Crestani Bruno, van der Poll Tom, Borensztajn Keren, Spek C. Arnold Pharmacological Targeting of Protease-Activated Receptor 2 Affords Protection from Bleomycin-Induced Pulmonary Fibrosis Molecular medicine (Cambridge, Mass.) 2015;21 (1):576-583 [PubMed]
  • Lin Cong Potential novel targets: Protease-activated receptors in idiopathic pulmonary fibrosis 2015. 147p. ISBN 9789462991293. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van der Poll T.; Co-supervisors: Spek C. A., Borensztajn K.)
  • Lin Cong, Rezaee Farhad, Waasdorp Maaike, Shi Kun, van der Poll Tom, Borensztajn Keren, Spek C. Arnold Protease activated receptor-1 regulates macrophage-mediated cellular senescence: a risk for idiopathic pulmonary fibrosis Oncotarget 2015;6 (34):35304-35314 [PubMed]
  • Lin Cong, von der Thüsen Jan, Daalhuisen Joost, ten Brink Marieke, Crestani Bruno, van der Poll Tom, Borensztajn Keren, Spek C. Arnold Protease-activated receptor (PAR)-2 is required for PAR-1 signalling in pulmonary fibrosis Journal of cellular and molecular medicine 2015;19 (6):1346-1356 [PubMed]

2014

  • Duitman Janwillem, Borensztajn Keren S., Pulskens Willem P. C., Leemans Jaklien C., Florquin Sandrine, Spek C. Arnold CCAAT-enhancer binding protein delta (C/EBPδ) attenuates tubular injury and tubulointerstitial fibrogenesis during chronic obstructive nephropathy Laboratory investigation; a journal of technical methods and pathology 2014;94 (1):89-97 [PubMed]
  • Duitman Jan Willem Infectious diseases and fibrotic disorders: potential novel targets 2014. 194p. ISBN 9789088918636. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Florquin Sandrine, van der Poll Tom; Co-supervisors: Spek Arnold, Peppelenbosch M. P.)
  • Duitman Janwillem, Ruela-de-Sousa Roberta R., Shi Kun, de Boer Onno J., Borensztajn Keren S., Florquin Sandrine, Peppelenbosch Maikel P., Spek C. Arnold Protease activated receptor-1 deficiency diminishes bleomycin-induced skin fibrosis Molecular medicine (Cambridge, Mass.) 2014;20:410-416 [PubMed]
  • Queiroz Karla C. S., Shi Kun, Duitman Janwillem, Aberson Hella L., Wilmink Johanna W., van Noesel Carel J. M., Richel Dick J., Spek C. Arnold Protease-activated receptor-1 drives pancreatic cancer progression and chemoresistance International journal of cancer. Journal international du cancer 2014;135 (10):2294-2304 [PubMed]
  • Shi Kun, Queiroz Karla C. S., Roelofs Joris J. T. H., van Noesel Carel J. M., Richel Dirk J., Spek C. Arnold Protease-activated receptor 2 suppresses lymphangiogenesis and subsequent lymph node metastasis in a murine pancreatic cancer model Journal of pathology 2014;234 (3):398-409 [PubMed]
  • Lin Cong, Duitman Janwillem, Daalhuisen Joost, ten Brink Marieke, von der Thüsen Jan, van der Poll Tom, Borensztajn Keren, Spek C. Arnold Targeting protease activated receptor-1 with P1pal-12 limits bleomycin-induced pulmonary fibrosis Thorax 2014;69 (2):152-160 [PubMed]
  • Stuijver D. J. F., Elbers L. P. B., van Zaane B., Dekkers O. M., Spek C. A., Gerdes V. E. A., Reitsma P. H., Brandjes D. P. M. The effect of levothyroxine on expression of inflammation-related genes in healthy subjects: a controlled randomized crossover study Hormone and metabolic research. Hormon- und Stoffwechselforschung. Hormones et metabolisme 2014;46 (11):789-793 [PubMed]

2013

  • Duitman J., Teske G. J. D., Butter L. M., Leemans J. C., Florquin S., Spek C. A. CCAAT/enhancer-binding protein delta (C/EBPδ) plays a minor role in renal host defense against uropathogenic Escherichia coli Transplant infectious disease 2013;15 (3):E119-E121 [PubMed]
  • Duitman Janwillem, Schouten Marcel, Groot Angelique P., Borensztajn Keren S., Daalhuisen Joost B., Florquin Sandrine, van der Poll Tom, Spek C. Arnold CCAAT/enhancer-binding protein delta facilitates bacterial dissemination during pneumococcal pneumonia in a platelet-activating factor receptor-dependent manner (vol 109, pg 9113, 2012) Proceedings of the National Academy of Sciences of the United States of America 2013;110 (37):15163 [PubMed]
  • Duitman Jan Willem, Hoogendijk Arie J., van der Poll Tom, Spek C. Arnold CCAAT/enhancer-binding protein δ: multifaceted regulator in respiratory disease American journal of pathology 2013;182 (4):1459-1460 [PubMed]
  • Machado Daisy, Shishido Silvia M., Queiroz Karla C. S., Oliveira Diogo N., Faria Ana L. C., Catharino Rodrigo R., Spek C. Arnold, Ferreira Carmen V. Irradiated riboflavin diminishes the aggressiveness of melanoma in vitro and in vivo PLoS ONE 2013;8 (1):e54269 [PubMed]
  • Shi K., Queiroz K. C. S., Stap J., Richel D. J., Spek C. A. Protease-activated receptor-2 induces migration of pancreatic cancer cells in an extracellular ATP-dependent manner Journal of thrombosis and haemostasis 2013;11 (10):1892-1902 [PubMed]
  • van den Hengel Lisa G., Hellingman Alwine A., Nossent Anne Yael, van Oeveren-Rietdijk Annemarie M., de Vries Margreet R., Spek C. Arnold, van Zonneveld Anton Jan, Reitsma Pieter H., Hamming Jaap F., de Boer Hetty C., Versteeg Henri H., Quax Paul H. A. Protease-activated receptor (PAR)2, but not PAR1, is involved in collateral formation and anti-inflammatory monocyte polarization in a mouse hind limb ischemia model PLoS ONE 2013;8 (4):e61923 [PubMed]

2012

  • Duitman Janwillem, Hoogendijk Arie J., Groot Angelique P., Ruela de Sousa Roberta R., van der Poll Tom, Florquin Sandrine, Spek C. Arnold CCAAT-Enhancer Binding Protein Delta (C/EBP delta) Protects Against Klebsiella pneumoniae-Induced Pulmonary Infection: Potential Role for Macrophage Migration Journal of infectious diseases 2012;206 (12):1826-1835 [PubMed]
  • Duitman Janwillem, Schouten Marcel, Groot Angelique P., Daalhuisen Joost B., Florquin Sandrine, van der Poll Tom, Spek C. Arnold CCAAT/enhancer-binding protein delta facilitates bacterial dissemination during pneumococcal pneumonia in a platelet-activating factor receptor-dependent manner Proceedings of the National Academy of Sciences of the United States of America 2012;109 (23):9113-9118 [PubMed]
  • Dashty Monireh, Akbarkhanzadeh Vishtaseb, Zeebregts Clark J., Spek C. Arnold, Sijbrands Eric J., Peppelenbosch Maikel P., Rezaee Farhad Characterization of coagulation factor synthesis in nine human primary cell types Scientific reports 2012;2:787 [PubMed]
  • Queiroz Karla C. S., Bijlsma Maarten F., Tio René A., Zeebregts Clark J., Dunaeva Marina, Ferreira Carmen V., Fuhler Gwenny M., Kuipers Ernst J., Alves Maria M., Rezaee Farhad, Spek C. Arnold, Peppelenbosch Maikel P. Dichotomy in Hedgehog Signaling between Human Healthy Vessel and Atherosclerotic Plaques Molecular medicine (Cambridge, Mass.) 2012;18 (7):1122-1127 [PubMed]
  • Reuwer Anne Q., Nowak-Sliwinska Patrycja, Mans Laurie A., van der Loos Chris M., von der Thüsen Jan H., Twickler Marcel Th B., Spek C. Arnold, Goffin Vincent, Griffioen Arjan W., Borensztajn Keren S. Functional consequences of prolactin signalling in endothelial cells: a potential link with angiogenesis in pathophysiology? Journal of cellular and molecular medicine 2012;16 (9):2035-2048 [PubMed]
  • Borensztajn Keren, Duitman Janwillem, Brüggemann Lois W., Spek C. Arnold Protease-activated receptor-4 deficiency does not protect against bleomycin-induced pulmonary fibrosis in mice European respiratory journal 2012;40 (4):1056-1057 [PubMed]
  • Queiroz Karla C. S., Spek C. Arnold, Peppelenbosch Maikel P. Targeting Hedgehog signaling and understanding refractory response to treatment with Hedgehog pathway inhibitors Drug resistance updates 2012;15 (4):211-222 [PubMed]
  • Limper Maarten, van de Stadt Lotte, Bos Wouter, de Kruif Martijn, Spek Arnold, Wolbink Gertjan, van Schaardenburg Dirkjan, van Gorp Eric The Acute-phase Response Is Not Predictive for the Development of Arthritis in Seropositive Arthralgia - A Prospective Cohort Study Journal of rheumatology 2012;39 (10):1914-1917 [PubMed]
  • Spek C. Arnold, Arruda Valder R. The protein C pathway in cancer metastasis Thrombosis research 2012;129 (1):S80-S84 [PubMed]
  • Queiroz Karla C. S., Milani Renato, Ruela-de-Sousa Roberta R., Fuhler Gwenny M., Justo Giselle Z., Zambuzzi Willian F., Duran Nelson, Diks Sander H., Spek C. Arnold, Ferreira Carmen V., Peppelenbosch Maikel P. Violacein Induces Death of Resistant Leukaemia Cells via Kinome Reprogramming, Endoplasmic Reticulum Stress and Golgi Apparatus Collapse PLoS ONE 2012;7 (10):e45362 [PubMed]

2011

  • Borensztajn Keren, Spek C. Arnold Blood coagulation factor Xa as an emerging drug target Expert opinion on therapeutic targets 2011;15 (3):341-349 [PubMed]
  • van Sluis G. L., Brüggemann L. W., Esmon C. T., Kamphuisen P. W., Richel D. J., Büller H. R., van Noorden C. J. F., Spek C. A. Endogenous activated protein C is essential for immune-mediated cancer cell elimination from the circulation Cancer letters 2011;306 (1):106-110 [PubMed]
  • Klümpen Heinz-Josef, Queiroz Karla C. S., Spek C. Arnold, van Noesel Carel J. M., Brink Helmy C., de Leng Wendy W. J., de Wilde Roeland F., Mathus-Vliegen Elisabeth M. H., Offerhaus G. Johan A., Alleman Maarten A., Westermann Anneke M., Richel Dirk J. mTOR inhibitor treatment of pancreatic cancer in a patient With Peutz-Jeghers syndrome Journal of clinical oncology 2011;29 (6):e150-e153 [PubMed]
  • Queiroz Karla C., Spek C. Arnold Response to Comment on "Tissue Factor-Dependent Chemokine Production Aggravates Experimental Colitis" Molecular medicine (Cambridge, Mass.) 2011;17 (11-12):1132 [PubMed]
  • Borensztajn Keren S., von der Thüsen Jan H., Spek C. Arnold The role of coagulation in chronic inflammatory disorders: a jack of all trades Current pharmaceutical design 2011;17 (1):9-16 [PubMed]
  • Horowitz Netanel A., Blevins Elizabeth A., Miller Whitney M., Perry Ashley R., Talmage Kathryn E., Mullins Eric S., Flick Matthew J., Queiroz Karla C. S., Shi Kun, Spek C. Arnold, Conway Edward M., Monia Brett P., Weiler Hartmut, Degen Jay L., Palumbo Joseph S. Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain Blood 2011;118 (10):2889-2895 [PubMed]
  • Queiroz Karla C. S., van 't Veer Cornelis, van den Berg Yascha, Duitman Janwillem, Versteeg Henri H., Aberson Hella L., Groot Angelique P., Verstege Marleen I., Roelofs Joris J. T. H., te Velde Anje A., Spek C. Arnold Tissue factor-dependent chemokine production aggravates experimental colitis Molecular medicine (Cambridge, Mass.) 2011;17 (9-10):1119-1126 [PubMed]

2010

  • de Kruif Martijn D., Limper Maarten, Gerritsen Herman, Spek C. Arnold, Brandjes Dees P. M., ten Cate Hugo, Bossuyt Patrick M., Reitsma Pieter H., van Gorp Eric C. M. Additional value of procalcitonin for diagnosis of infection in patients with fever at the emergency department Critical care medicine 2010;38 (2):457-463 [PubMed]
  • van Sluis Geerte L., Nieuwdorp Max, Kamphuisen Pieter W., van der Vlag Johan, van Noorden Cornelis J. F., Spek C. Arnold A Low Molecular Weight Heparin Inhibits Experimental Metastasis in Mice Independently of the Endothelial Glycocalyx PLoS ONE 2010;5 (6):e11200 [PubMed]
  • Brüggemann Lois W., Queiroz Karla C. S., Zamani Khatera, van Straaten Amber, Spek C. Arnold, Bijlsma Maarten F. Assessing the efficacy of the hedgehog pathway inhibitor vitamin D3 in a murine xenograft model for pancreatic cancer Cancer biology & therapy 2010;10 (1):79-88 [PubMed]
  • van Sluis Geerte L. Cancer, haemostasis and coagulans 2010. 249p. ISBN 9789090252124. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Büller Harry R., van Noorden C. J. F.; Co-supervisors: Spek C. A., Richel D. J.)
  • Spek C. Arnold, Bijlsma Maarten F., Queiroz Karla C. S. Canonical Hedgehog signaling drives proangiogenic responses in endothelial cells Cell cycle (Georgetown, Tex.) 2010;9 (9):1683 [PubMed]
  • Borensztajn Keren, Peppelenbosch Maikel P., Spek C. Arnold Coagulation Factor Xa inhibits cancer cell migration via LIMK1-mediated cofilin inactivation Thrombosis research 2010;125 (6):E323-E328 [PubMed]
  • van Noorden Cornelis J. F., van Sluis Geerte L., Spek C. Arnold Experimental and clinical effects of anticoagulants on cancer progression Thrombosis research 2010;125 (Suppl. 2):S77-S79 [PubMed]
  • Queiroz K. C. S., Ruela-de-Sousa R. R., Fuhler G. M., Aberson H. L., Ferreira C. V., Peppelenbosch M. P., Spek C. A. Hedgehog signaling maintains chemoresistance in myeloid leukemic cells Oncogene 2010;29 (48):6314-6322 [PubMed]
  • Queiroz Karla C. S., Tio René, Zeebregts Clark, Bijlsma Maarten F., Zijlstra Felix, Badlou Bahram, de Vries Marcel, Ferreira Carmen V., Spek C. Arnold, Peppelenbosch Maikel P., Rezaee Farhad Human Plasma Very Low Density Lipoprotein Carries Indian Hedgehog Journal of proteome research 2010;9 (11):6052-6059 [PubMed]
  • Jong Eefje, Meijers Joost C. M., van Gorp Eric C. M., Spek C. Arnold, Mulder Jan W. Markers of inflammation and coagulation indicate a prothrombotic state in HIV-infected patients with long-term use of antiretroviral therapy with or without abacavir AIDS research and therapy 2010;7 (1):9 [PubMed]
  • Pintao Maria, Garcia A. A., Borgel D., Alhenc-Gelas M., Spek C. A., de Visser M. C. H., Gandrille S., Reitsma P. H. Novel human pathological mutations. Gene symbol: PROS1. Disease: Protein S deficiency Human genetics 2010;127 (1):121 [PubMed]
  • Klerk Clara P. W., Niers Tatjana M. H., Brüggemann Lois W., Smorenburg Susanne M., Richel Dick J., Spek C. Arnold, van Noorden Cornelis J. F. Prophylactic plasma levels of the low molecular weight heparin nadroparin does not affect colon cancer tumor development in mouse liver Thrombosis research 2010;125 (3):235-238 [PubMed]
  • Spek C. Arnold, Brüggemann Lois W., Borensztajn Keren S. Protease-Activated Receptor 2 Blocking Peptide Counteracts Endotoxin-Induced Inflammation and Coagulation and Ameliorates Renal Fibrin Deposition in a Rat Model of Acute Renal Failure Shock (Augusta, Ga.) 2010;33 (3):339 [PubMed]
  • Borensztajn Keren, Bresser Paul, van der Loos Chris, Bot Ilze, van den Blink Bernt, den Bakker Michael A., Daalhuisen Joost, Groot Angelique P., Peppelenbosch Maikel P., von der Thüsen Jan H., Spek C. Arnold Protease-Activated Receptor-2 Induces Myofibroblast Differentiation and Tissue Factor Up-Regulation during Bleomycin-Induced Lung Injury Potential Role in Pulmonary Fibrosis American journal of pathology 2010;177 (6):2753-2764 [PubMed]
  • de Kruif Martijn D., Limper Maarten, Sierhuis Karlien, Wagenaar Jiri F. P., Spek C. Arnold, Garlanda Cecilia, Cotena Alessia, Mantovani Alberto, ten Cate Hugo, Reitsma Pieter H., van Gorp Eric C. M. PTX3 predicts severe disease in febrile patients at the emergency department Journal of infection 2010;60 (2):122-127 [PubMed]
  • Borensztajn Keren, von der Thüsen Jan H., Peppelenbosch Maikel P., Spek C. Arnold The coagulation factor Xa/protease activated receptor-2 axis in the progression of liver fibrosis: a multifaceted paradigm Journal of cellular and molecular medicine 2010;14 (1-2):143-153 [PubMed]
  • Bijlsma Maarten F., Spek C. Arnold The Hedgehog morphogen in myocardial ischemia-reperfusion injury Experimental biology and medicine (Maywood, N.J.) 2010;235 (4):447-454 [PubMed]
  • van Sluis Geerte L., Büller Harry R., Spek C. Arnold The role of activated protein C in cancer progression Thrombosis research 2010;125 (Suppl. 2):S138-S142 [PubMed]

2009

  • Loubele Sarah T. B. G., Spek C. Arnold, Leenders Peter, van Oerle René, Aberson Hella L., Hamulyák Karly, Ferrell Gary, Esmon Charles T., Spronk Henri M. H., ten Cate Hugo Activated Protein C Protects Against Myocardial Ischemia/Reperfusion Injury via Inhibition of Apoptosis and Inflammation Arteriosclerosis, thrombosis, and vascular biology 2009;29 (7):1087-U159 [PubMed]
  • Loubele S. T. B. G., Spek C. A., Leenders P., van Oerle R., Aberson H. L., van der Voort D., Hamulyák K., Petersen L. C., Spronk H. M. H., ten Cate H. Active site inhibited factor VIIa attenuates myocardial ischemia/reperfusion injury in mice Journal of thrombosis and haemostasis 2009;7 (2):290-298 [PubMed]
  • van den Berg Y. W., van den Hengel L. G., Myers H. R., Ayachi O., Jordanova E., Ruf W., Spek C. A., Reitsma P. H., Bogdanov V. Y., Versteeg H. H. Alternatively spliced tissue factor induces angiogenesis through integrin ligation Proceedings of the National Academy of Sciences of the United States of America 2009;106 (46):19497-19502 [PubMed]
  • Borensztajn Keren, Aberson Hella, Groot Angelique P., Peppelenbosch Maikel P., Spek C. Arnold A mechanism for thrombin-dependent lung metastasis in patients with osteosarcoma British journal of haematology 2009;145 (4):548-550 [PubMed]
  • Monti Monia, Borensztajn Keren S., Pinotti Mirko, Canella Alessandro, Branchini Alessio, Marchetti Giovanna, Reitsma Pieter H., Bernardi Francesco, Spek C. Arnold Characterization of the intracellular signalling capacity of natural FXa mutants with reduced pro-coagulant activity Thrombosis research 2009;123 (6):914-918 [PubMed]
  • Borensztajn Keren, Bijlsma Maarten F., Reitsma Pieter H., Peppelenbosch Maikel P., Spek C. Arnold Coagulation Factor Xa inhibits cancer cell migration via Protease-activated receptor-1 activation Thrombosis research 2009;124 (2):219-225 [PubMed]
  • Borensztajn Keren, Peppelenbosch Maikel P., Spek C. Arnold Coagulation factor Xa signaling: the link between coagulation and inflammatory bowel disease? Trends in pharmacological sciences 2009;30 (1):8-16 [PubMed]
  • Bisoendial Radjesh J., Birjmohun Rakesh S., Akdim Fatima, van 't Veer Cornelis, Spek C. Arnold, Hartman Daniel, de Groot Els R., Bankaitis-Davis Danute M., Kastelein John J. P., Stroes Erik S. G. C-Reactive Protein Elicits White Blood Cell Activation in Humans American journal of medicine 2009;122 (6):582.e1-582.e9 [PubMed]
  • Niers Tatjana M. H., Brüggemann Lois W., Klerk Clara P. W., Muller Femke J. M., Buckle Tessa, Reitsma Pieter H., Richel Dick J., Spek C. Arnold, van Tellingen Olaf, van Noorden Cornelis J. F. Differential effects of anticoagulants on tumor development of mouse cancer cell lines B16, K1735 and CT26 in lung Clinical & experimental metastasis 2009;26 (3):171-178 [PubMed]
  • de Kruif M. D., Limper M., Hansen H. R., de Ruiter J., Spek C. A., van Gorp E. C. M., ten Berge I. J., Rowshani A. T., ten Cate H., Meesters E. W. Effects of a 3-month course of rosuvastatin in patients with systemic lupus erythematosus Annals of the rheumatic diseases 2009;68 (10):1654 [PubMed]
  • van Sluis Geerte L., Niers Tatjana M. H., Esmon Charles T., Tigchelaar Wikky, Richel Dick J., Buller Harry R., van Noorden Cornelis J. F., Spek C. Arnold Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1-mediated vascular endothelial barrier enhancement Blood 2009;114 (9):1968-1973 [PubMed]
  • Borensztajn Keren, Aberson Hella, Peppelenbosch Maikel P., Spek C. Arnold FXa-induced intracellular signaling links coagulation to neoangiogenesis: Potential implications for fibrosis BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 2009;1793 (5):798-805 [PubMed]
  • Dessing Mark C., van der Sluijs Koenraad F., Spek C. Arnold, van der Poll Tom Gene expression profiles in murine influenza pneumonia Journal of innate immunity 2009;1 (4):366-375 [PubMed]
  • Pintao Maria C., Garcia A. A., Borgel D., Alhenc-Gelas M., Spek C. A., de Visser M. C. H., Gandrille S., Reitsma Pieter H. Gross deletions/duplications in PROS1 are relatively common in point mutation-negative hereditary protein S deficiency Human genetics 2009;126 (3):449-456 [PubMed]
  • Bijlsma Maarten F., Groot Angelique P., Oduro Jeremiah P., Franken Rutger J., Schoenmakers Saskia H. H. F., Peppelenbosch Maikel P., Spek C. Arnold Hypoxia induces a hedgehog response mediated by HIF-1alpha Journal of cellular and molecular medicine 2009;13 (8B):2053-2060 [PubMed]
  • Miller Jacquelyn, Agarwal Anika, Devi Lakshmi A., Fontanini Kellen, Hamilton James A., Pin Jean-Philippe, Shields Denis C., Spek C. Arnold, Sakmar Thomas P., Kuliopulos Athan, Hunt Stephen W. Insider access: pepducin symposium explores a new approach to GPCR modulation Annals of the New York Academy of Sciences 2009;1180 (Suppl. 1):E1-12 [PubMed]
  • Borensztajn K., Peppelenbosch M. P., Spek C. A. Letter in response to 'Coagulation and fibrosis in chronic liver disease' Gut 2009;58 (11):1565-1566 [PubMed]
  • Niers T. M. H., Brüggemann L. W., van Sluis G. L., Liu R. D., Versteeg H. H., Büller H. R., van Noorden C. J. F., Reitsma P. H., Spek C. A., Richel D. J. Long-term thrombin inhibition promotes cancer cell extravasation in a mouse model of experimental metastasis Journal of thrombosis and haemostasis 2009;7 (9):1595-1597 [PubMed]

2008

  • van Baal Jantine W. P. M., Milana Francesco, Rygiel Agnieszka M., Sondermeijer Carine M. T., Spek C. Arnold, Bergman Jacques J. G. H. M., Peppelenbosch Maikel P., Krishnadath Kausilia K. A comparative analysis by SAGE of gene expression profiles of esophageal adenocarcinoma and esophageal squamous cell carcinoma Cellular oncology 2008;30 (1):63-75 [PubMed]
  • Niers Tatjana M. H. Coagulation, angiogenesis and cancer 2008. 199p. ISBN 9789064642579. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Richel D. J., van Noorden C. J.; Co-supervisors: Büller H. R., Spek C. A.)
  • de Kruif Martijn D., Setiati Tatty E., Mairuhu Albertus T. A., Koraka Penelopie, Aberson Hella A., Spek C. Arnold, Osterhaus Albert D. M. E., Reitsma Pieter H., Brandjes Dees P. M., Soemantri Augustinus, van Gorp Eric C. M. Differential Gene Expression Changes in Children with Severe Dengue Virus Infections PLoS neglected tropical diseases 2008;2 (4):e215 [PubMed]
  • Bijlsma Maarten F., Leenders Peter J. A., Janssen Ben J. A., Peppelenbosch Maikel P., ten Cate Hugo, Spek C. Arnold Endogenous hedgehog expression contributes to myocardial ischemia-reperfusion-induced injury Experimental biology and medicine (Maywood, N.J.) 2008;233 (8):989-996 [PubMed]
  • Brüggemann Lois W., Versteeg Henri H., Niers Tatjana M., Reitsma Pieter H., Spek C. Arnold Experimental melanoma metastasis in lungs of mice with congenital coagulation disorders Journal of cellular and molecular medicine 2008;12 (6B):2622-2627 [PubMed]
  • Borensztajn Keren, Peppelenbosch Maikel P., Spek C. Arnold Factor Xa: at the crossroads between coagulation and signaling in physiology and disease Trends in molecular medicine 2008;14 (10):429-440 [PubMed]
  • Borensztajn Keren, Stiekema Jurriën, Nijmeijer Sebastiaan, Reitsma Pieter H., Peppelenbosch Maikel P., Spek C. Arnold Factor Xa stimulates proinflammatory and profibrotic responses in fibroblasts via protease-activated receptor-2 activation American journal of pathology 2008;172 (2):309-320 [PubMed]
  • van Baal J. W. P. M., Rygiel A. M., Milano F., Anderson M., Bergman J. J. G. H. M., Spek C. A., Wang K. K., Peppelenbosch M. P., Krishnadath K. K. Gene expression profile comparison of Barrett's esophagus epithelial cell cultures and biopsies Diseases of the esophagus 2008;21 (7):628-633 [PubMed]
  • Brüggemann Lois W., Versteeg Henri H., Reitsma Pieter H., Spek C. Arnold High factor VIIa levels do not promote tumor metastasis Thrombosis and haemostasis 2008;99 (4):787-788 [PubMed]
  • de Kruif Martijn D. Inflammation and coagulation 2008. 210p. ISBN 9789064642715. [UvA Dissertations Online] University of Amsterdam. (Supervisors: ten Cate H., Reitsma P. H.; Co-supervisors: van Gorp E. C. M., Spek C. A.)
  • Bijlsma Maarten F., Peppelenbosch Maikel P., Spek C. Arnold, Roelink Henk Leukotriene synthesis is required for hedgehog-dependent neurite projection in neuralized embryoid bodies but not for motor neuron differentiation Stem cells (Dayton, Ohio) 2008;26 (5):1138-1145 [PubMed]
  • Bijlsma Maarten Fokke Novel mechanism and functions for hedgehog signaling in development and disease 2008. 107p. ISBN 9789064642821. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Peppelenbosch M. P.; Co-supervisor: Spek C. A.)
  • Borensztajn Keren S., Spek C. Arnold Protease-activated receptors, apoptosis and tumor growth Pathophysiology of haemostasis and thrombosis 2008;36 (3-4):137-147 [PubMed]
  • Bijlsma Maarten F., Peppelenbosch Maikel P., Spek C. Arnold (Pro-)vitamin D as treatment option for hedgehog-related malignancies Medical hypotheses 2008;70 (1):202-203 [PubMed]
  • Versteeg H. H., Borensztajn K. S., Kerver M. E., Ruf W., Reitsma P. H., Spek C. A., Peppelenbosch M. P. TF:FVIIa-specific activation of CREB upregulates proapoptotic proteins via protease-activated receptor-2 Journal of thrombosis and haemostasis 2008;6 (9):1550-1557 [PubMed]
  • Brüggemann Lois W. The role of blood coagulation in cancer, inflammation and embryonic development 2008. 198p. ISBN 9789064642593. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Reitsma P. H.; Co-supervisors: Spek C. A., Versteeg H. H.)

2007

  • Borensztajn Keren S., Bijlsma Maarten F., Groot Angelique P., Bruggemann Lois W., Versteeg Henri H., Reitsma Pieter H., Peppelenbosch Maikel P., Spek C. Arnold Coagulation factor Xa drives tumor cells into apoptosis through BH3-only protein Bim up-regulation Experimental cell research 2007;313 (12):2622-2633 [PubMed]
  • Klerk C. P. W., Smorenburg S. M., Spek C. A., van Noorden C. J. F. Colon cancer metastasis in mouse liver is not affected by hypercoagulability due to Factor V Leiden mutation Journal of cellular and molecular medicine 2007;11 (3):561-568 [PubMed]
  • Spek C. Arnold, ten Kate Fiebo J. W., te Velde Anje A. Factor V Leiden and the etiology of inflammatory bowel disease Thrombosis and haemostasis 2007;98 (3):670-673 [PubMed]
  • Slofstra Sjoukje H., Groot Angelique P., Obdeijn Maartje H. P., Reitsma Pieter H., ten Cate Hugo, Spek C. Arnold Gene expression profiling identifies C/EBP delta as a candidate regulator of endotoxin-induced disseminated intravascular coagulation American journal of respiratory and critical care medicine 2007;176 (6):602-609 [PubMed]
  • Hansen Hjalmar R., Wolfs Jef L., Bruggemann Lois, Sommeijer Dirkje W., Bevers Eduard, Hauer Arnaud D., Kuiper Johan, Spek C. Arnold, Spronk Henri M. H., Reitsma Pieter H., ten Cate Hugo Hyperglycemia accelerates arterial thrombus formation and attenuates the antithrombotic response to endotoxin in mice Blood coagulation & fibrinolysis 2007;18 (7):627-636 [PubMed]
  • Slofstra S. H. Pathophysiological mechanisms in disseminated intravascular coagulation 2007. 181p. ISBN 9789064641015. [UvA Dissertations Online] University of Amsterdam. (Supervisors: ten Cate H., Reitsma P. H.; Co-supervisor: Spek C. Arnold)
  • Slofstra Sjoukje H., Bijlsma Maarten F., Groot Angelique P., Reitsma Pieter H., Lindhout Theo, ten Cate Hugo, Spek C. Arnold Protease-activated receptor-4 inhibition protects from multiorgan failure in a murine model of systemic inflammation Blood 2007;110 (9):3176-3182 [PubMed]
  • Bijlsma Maarten F., Borensztajn Keren S., Roelink Henk, Peppelenbosch Maikel P., Spek C. Arnold Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites Cellular signalling 2007;19 (12):2596-2604 [PubMed]

2006

  • Bijlsma Maarten F., Peppelenbosch Maikel P., Spek C. Arnold A dual role for 7-dehydrocholesterol reductase in regulating Hedgehog signalling? Development (Cambridge, England) 2006;133 (20):3951; author reply 3952-3951; author reply 3953 [PubMed]
  • Brüggemann L. W., Drijfhout J. W., Reitsma P. H., Spek C. A. Alternatively spliced tissue factor in mice: induction by Streptococcus pneumoniae Journal of thrombosis and haemostasis 2006;4 (4):918-920 [PubMed]
  • van Zoelen Marieke A. D., Bakhtiari Kamran, Dessing Mark C., van't Veer Cornelis, Spek C. Arnold, Tanck Michael, Meijers Joost C., van der Poll Tom Ethyl pyruvate exerts combined anti-inflammatory and anticoagulant effects on human monocytic cells Thrombosis and haemostasis 2006;96 (6):789-793 [PubMed]
  • Bijlsma Maarten F., Peppelenbosch Maikel P., Spek C. Arnold Hedgehog morphogen in cardiovascular disease Circulation 2006;114 (18):1985-1991 [PubMed]
  • Bijlsma Maarten F., Spek C. Arnold, Peppelenbosch Maikel P. Hedgehog turns lipoproteins into Janus-faced particles Trends in cardiovascular medicine 2006;16 (7):217-220 [PubMed]
  • Slofstra S. H., Groot A. P., Maris N. A., Reitsma P. H., Cate H. Ten, Spek C. A. Inhalation of activated protein C inhibits endotoxin-induced pulmonary inflammation in mice independent of neutrophil recruitment British journal of pharmacology 2006;149 (6):740-746 [PubMed]
  • Rijneveld Anita W., Weijer Sebastiaan, Bresser Paul, Florquin Sandrine, Vlasuk George P., Rote William E., Spek C. Arnold, Reitsma Pieter H., van der Zee Jaring S., Levi Marcel, van der Poll Tom Local activation of the tissue factor-factor VIIa pathway in patients with pneumonia and the effect of inhibition of this pathway in murine pneumococcal pneumonia Critical care medicine 2006;34 (6):1725-1730 [PubMed]
  • Slofstra Sjoukje H., ten Cate Hugo, Spek C. Arnold Low dose endotoxin priming is accountable for coagulation abnormalities and organ damage observed in the Shwartzman reaction. A comparison between a single-dose endotoxemia model and a double-hit endotoxin-induced Shwartzman reaction Thrombosis journal 2006;4:13 [PubMed]
  • Bonta Peter I., van Tiel Claudia M., Vos Mariska, Pols Thijs W. H., van Thienen Johannes V., Ferreira Valérie, Arkenbout E. Karin, Seppen Jurgen, Spek C. Arnold, van der Poll Tom, Pannekoek Hans, de Vries Carlie J. M. Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses Arteriosclerosis, thrombosis, and vascular biology 2006;26 (10):2288-2294 [PubMed]
  • Bijlsma Maarten F., Spek C. Arnold, Zivkovic Danica, van de Water Sandra, Rezaee Farhad, Peppelenbosch Maikel P. Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion PLoS biology 2006;4 (8):e232-1410 [PubMed]
  • Brüggemann Lois W., Schoenmakers Saskia H. H. F., Groot Angelique P., Reitsma Pieter H., Spek C. Arnold Role of the factor V Leiden mutation in septic peritonitis assessed in factor V Leiden transgenic mice Critical care medicine 2006;34 (8):2201-2206 [PubMed]
  • Slofstra Sjoukje H., ten Cate Hugo, Spek C. Arnold Signal transduction induced by activated protein C: no role in protection against sepsis? Trends in molecular medicine 2006;12 (8):374-381 [PubMed]
  • Maris N. A., Dessing M. C., de Vos A. F., Bresser P., van der Zee J. S., Jansen H. M., Spek C. A., van der Poll T. Toll-like receptor mRNA levels in alveolar macrophages after inhalation of endotoxin European respiratory journal 2006;28 (3):622-626 [PubMed]

2005

  • Maris Nico A., de Vos Alex F., Dessing Mark C., Spek C. Arnold, Lutter Rene, Jansen Henk M., van der Zee Jaring S., Bresser Paul, van der Poll Tom Antiinflammatory effects of salmeterol after inhalation of lipopolysaccharide by healthy volunteers American journal of respiratory and critical care medicine 2005;172 (7):878-884 [PubMed]
  • Schoenmakers Saskia H. H. F., Reitsma Pieter H., Spek C. Arnold Blood coagulation factors as inflammatory mediators Blood cells, molecules & diseases 2005;34 (1):30-37 [PubMed]
  • Braat Henri, Stokkers Pieter, Hommes Tijmen, Cohn Danny, Vogels Esther, Pronk Inge, Spek Arnold, van Kampen Antoine, van Deventer Sander, Peppelenbosch Maikel, Hommes Daan Consequence of functional Nod2 and Tlr4 mutations on gene transcription in Crohn's disease patients Journal of molecular medicine (Berlin, Germany) 2005;83 (8):601-609 [PubMed]
  • Spek C. A., van Zoelen M., Diks S. H., Peppelenbosch M. P. Functional evolution of tissue factor, the archetype of the cytokine receptor family CURRENT GENOMICS 2005;6 (6):367-373
  • Wettinger Stephanie Bezzina, Doggen Carine J. M., Spek C. Arnold, Rosendaal Frits R., Reitsma Pieter H. High throughput mRNA profiling highlights associations between myocardial infarction and aberrant expression of inflammatory molecules in blood cells Blood 2005;105 (5):2000-2006 [PubMed]
  • Borensztajn K., Spek C. A. Inherited coagulation factor VII and X deficiencies associated with severe bleeding diathesis: Molecular genetics and pathophysiology CURRENT GENOMICS 2005;6 (6):383-400
  • Slofstra Sjoukje H., van 't Veer Cornelis, Buurman Wim A., Reitsma Pieter H., ten Cate Hugo, Spek C. Arnold Low molecular weight heparin attenuates multiple organ failure in a murine model of disseminated intravascular coagulation Critical care medicine 2005;33 (6):1365-1370 [PubMed]
  • Peppelenbosch M. P., Milano F., Ferreira C. V., Knapinska A., Diks S. H., Spek C. A. RNA-based gene therapy for haemophilia B CURRENT GENOMICS 2005;6 (6):401-404
  • Schoenmakers S. H. H. F., Brüggemann L. W., Groot A. P., Maijs S., Reitsma P. H., Spek C. A. Role of coagulation FVIII in septic peritonitis assessed in hemophilic mice Journal of thrombosis and haemostasis 2005;3 (12):2738-2744 [PubMed]
  • Peppelenbosch M. P., Spek C. A. Understanding and Treatment of Diseases in the Haemostatic System - Editorial CURRENT GENOMICS 2005;6 (6):365

2004

  • Schoenmakers Saskia H. H. F., Groot Angelique P., Florquin Sandrine, Reitsma Pieter H., Spek C. Arnold Blood cell-derived tissue factor influences host response during murine endotoxemia Blood cells, molecules & diseases 2004;32 (2):325-333 [PubMed]
  • Versteeg Henri H., Spek C. Arnold, Richel Dick J., Peppelenbosch Maikel P. Coagulation factors VIIa and Xa inhibit apoptosis and anoikis Oncogene 2004;23 (2):410-417 [PubMed]
  • Versteeg H. H., Richel D. J., Peppelenbosch M. P., Spek C. A. Concerted action of coagulation factors on cell survival Journal of thrombosis and haemostasis 2004;2 (4):673-674 [PubMed]
  • Versteeg Henri H., Spek C. Arnold, Slofstra Sjoukje H., Diks Sander H., Richel Dick J., Peppelenbosch Maikel P. FVIIa:TF induces cell survival via G12/G13-dependent Jak/STAT activation and BclXL production Circulation research 2004;94 (8):1032-1040 [PubMed]
  • Bijlsma Maarten F., Spek C. Arnold, Peppelenbosch Maikel P. Hedgehog: an unusual signal transducer BioEssays 2004;26 (4):387-394 [PubMed]
  • Weijer Sebastian, Schoenmakers Saskia H. H. F., Florquin Sandrine, Levi Marcel, Vlasuk George P., Rote William E., Reitsma Pieter H., Spek C. Arnold, van der Poll Tom Inhibition of the tissue factor/factor VIIa pathway does not influence the inflammatory or antibacterial response to abdominal sepsis induced by Escherichia coli in mice Journal of infectious diseases 2004;189 (12):2308-2317 [PubMed]
  • Schoenmakers S. H. H. F. Studies on coagulation-induced inflammation in mice 2004. 149p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Reitsma P. H.; Co-supervisor: Spek C. A.)
  • Versteeg Henri H., Spek C. Arnold, Peppelenbosch Maikel P., Richel Dick J. Tissue factor and cancer metastasis: The role of intracellular and extracellular signaling pathways Molecular medicine (Cambridge, Mass.) 2004;10 (1-6):6-11 [PubMed]
  • Spek C. Arnold Tissue factor: from 'just one of the coagulation factors' to a major player in physiology Blood coagulation & fibrinolysis 2004;15 (Suppl. 1):S3-S10 [PubMed]
  • Schoenmakers S. H. H. F., Versteeg H. H., Groot A. P., Reitsma P. H., Spek C. A. Tissue factor haploinsufficiency during endotoxin induced coagulation and inflammation in mice Journal of thrombosis and haemostasis 2004;2 (12):2185-2193 [PubMed]

2003

  • Slofstra Sjoukje H., Spek C. Arnold, ten Cate Hugo Disseminated intravascular coagulation hematology journal 2003;4 (5):295-302 [PubMed]
  • Verbon Annelies, Meijers Joost C. M., Spek C. Arnold, Hack C. Erik, Pribble John P., Turner Terence, Dekkers Pascale E. P., Axtelle Tim, Levi Marcel, van Deventer Sander J. H., Reitsma Pieter H., van der Poll Tom Effects of IC14, an anti-CD14 antibody, on coagulation and fibrinolysis during low-grade endotoxemia in humans Journal of infectious diseases 2003;187 (1):55-61 [PubMed]
  • Eldering Eric, Spek C. Arnold, Aberson Hella L., Grummels Annette, Derks Ingrid A., de Vos Alex F., McElgunn Cathal J., Schouten Jan P. Expression profiling via novel multiplex assay allows rapid assessment of gene regulation in defined signalling pathways Nucleic acids research 2003;31 (23):e153 [PubMed]
  • Dörffler-Melly Janine, de Kruif Martijn, Schwarte Lothar A., Franco Rendrik F., Florquin Sandrine, Spek C. Arnold, Ince Can, Reitsma Pieter H., ten Cate Hugo Functional thrombomodulin deficiency causes enhanced thrombus growth in a murine model of carotid artery thrombosis Basic research in cardiology 2003;98 (6):347-352 [PubMed]
  • Peppelenbosch Maikel P., Versteeg Henri H., Spek C. Arnold In silico tissue factor analysis: a bit-to-bit comparison Thrombosis and haemostasis 2003;89 (3):592-593 [PubMed]
  • Versteeg H. H., Bresser H. L., Spek C. A., Richel D. J., van Deventer S. J. H., Peppelenbosch M. P. Regulation of the p21Ras-MAP kinase pathway by factor VIIa Journal of thrombosis and haemostasis 2003;1 (5):1012-1018 [PubMed]
  • Versteeg Henri H., Peppelenbosch Maikel P., Spek C. Arnold Tissue factor signal transduction in angiogenesis Carcinogenesis 2003;24 (6):1009-1013 [PubMed]
  • Spek C. Arnold, Verbon Annelies, Aberson Hella, Pribble John P., McElgunn Cathal J., Turner Terence, Axtelle Tim, Schouten Jan, van der Poll Tom, Reitsma Pieter H. Treatment with an anti-CD14 monoclonal antibody delays and inhibits lipopolysaccharide-induced gene expression in humans in vivo Journal of clinical immunology 2003;23 (2):132-140 [PubMed]

2002

  • Peppelenbosch Maikel P., Spek C. Arnold Type I diabetes: a role for tissue factor in pancreatic islet transplantation? Lancet 2002;360 (9350):1999-2000 [PubMed]

2001

  • ten Cate H., Schoenmakers S. H., Franco R., Timmerman J. J., Groot A. P., Spek C. A., Reitsma P. H. Microvascular coagulopathy and disseminated intravascular coagulation Critical care medicine 2001;29 (7 Suppl):S95-7; discussion S97-8 [PubMed]
  • Versteeg H. H., Peppelenbosch M. P., Spek C. A. The pleiotropic effects of tissue factor: a possible role for factor VIIa-induced intracellular signalling? Thrombosis and haemostasis 2001;86 (6):1353-1359 [PubMed]

2000

  • Spek C. A., Reitsma P. H. Genetic risk factors for venous thrombosis Molecular genetics and metabolism 2000;71 (1-2):51-61 [PubMed]
  • Franco R. F., de Jonge E., Dekkers P. E., Timmerman J. J., Spek C. A., van Deventer S. J., van Deursen P., van Kerkhoff L., van Gemen B., ten Cate H., van der Poll T., Reitsma P. H. The in vivo kinetics of tissue factor messenger RNA expression during human endotoxemia: relationship with activation of coagulation Blood 2000;96 (2):554-559 [PubMed]

1999

  • Spek A., Reitsma P. Type-I protein-C deficiency caused by disruption of a hepatocyte nuclear factor (HNF)-6/HNF-1 binding site in the human protein-C gene promoter Trends in cardiovascular medicine 1999;9 (3-4):82-85 [PubMed]
  • Spek C. A., Bertina R. M., Reitsma P. H. Unique distance- and DNA-turn-dependent interactions in the human protein C gene promoter confer submaximal transcriptional activity Biochemical journal 1999;340 ( Pt 2):513-518 [PubMed]

1998

  • Spek C. A., Bertina R. M., Reitsma P. H. Identification of evolutionarily invariant sequences in the protein C gene promoter Journal of molecular evolution 1998;47 (6):663-669 [PubMed]
  • Spek C. A., Lannoy V. J., Lemaigre F. P., Rousseau G. G., Bertina R. M., Reitsma P. H. Type I protein C deficiency caused by disruption of a hepatocyte nuclear factor (HNF)-6/HNF-1 binding site in the human protein C gene promoter Journal of biological chemistry 1998;273 (17):10168-10173 [PubMed]

1995

  • Spek C. A., Koster T., Rosendaal F. R., Bertina R. M., Reitsma P. H. Genotypic variation in the promoter region of the protein C gene is associated with plasma protein C levels and thrombotic risk Arteriosclerosis, thrombosis, and vascular biology 1995;15 (2):214-218 [PubMed]
  • Droog F., Spek A., van der Kooy A., de Ruyter A., Hoge H., Libbenga K., Hooykaas P., van der Zaal B. Promoter analysis of the auxin-regulated tobacco glutathione S-transferase genes Nt103-1 and Nt103-35 Plant molecular biology 1995;29 (3):413-429 [PubMed]
  • Spek C. A., Greengard J. S., Griffin J. H., Bertina R. M., Reitsma P. H. Two mutations in the promoter region of the human protein C gene both cause type I protein C deficiency by disruption of two HNF-3 binding sites Journal of biological chemistry 1995;270 (41):24216-24221 [PubMed]

1994

  • Spek C. A., Poort S. R., Bertina R. M., Reitsma P. H. Determination of the allelic and haplotype frequencies of three polymorphisms in the promoter region of the human protein C gene Blood coagulation & fibrinolysis 1994;5 (2):309-311 [PubMed]