C.M. Ribeiro PhD publications

foto

Publications PhD C.M. Ribeiro

Positions
Associate Professor, Research Associate
Main activities
Research
Specialisation
Immunology, Cellular & Molecular Biology, Virology, Autophagy
Focus of research

Our Autophagy-directed Immunity (ADI) research group focuses on elucidating the mechanisms governing autophagy pathways, ultimately aiming to maximize the therapeutic potential of targeting autophagy to intervene in chronic viral infections and inflammatory diseases. Autophagy pathways are not only endowed with the capacity to degrade viruses and instruct adaptive T cell-mediated responses, but also to mediate the release of cytosolic contents extracellularly and thereby control inflammatory output. We use both hypothesis-driven as well as unbiased genome-wide and proteomics approaches to define novel regulators and signalling components of autophagy pathways. In this context, we have recently discovered an important role for autophagy in restricting HIV-1 infection through a novel TRIM5α-Atg16L1-Atg5 mechanism. Currently, we are investigating the impact of the TRIM5α-mediated autophagy pathway on HIV-1 disease progression and inflammatory signatures.

 

Our major research lines are:

  1. Molecular Regulation of Degradative Autophagy and Secretory Autophagy in Viral Infections, with particular emphasis on HIV-1 and Dengue virus infection.  
  2. Function of Autophagy Molecules and Autophagy Vesicles on Virus Restriction, Molecular Inflammation and T-cell mediated Immunity - using organoid technology and ex vivo explant tissue models.
  3. Impact of Autophagy Mechanisms and Polymorphisms on Clinical Disease Outcomes

 

Current members:

  • Renée RCE Schreurs       - Postdoctoral fellow 
  • Alexandra PM Cloherty  - PhD candidate
  • Tracy-Jane THD Eisden  - PhD candidate [Alliance AMC-VUmc joint project]

 

For any enquiries, please contact: c.m.ribeiro@amsterdamumc.nl

 

 

Amsterdam UMC Research Institutes
AMC departments
All publications

2020

  • Sridhar Adithya, Simmini Salvatore, Ribeiro Carla M. S., Tapparel Caroline, Evers Melvin M., Pajkrt Dasja, Wolthers Katja A Perspective on Organoids for Virology Research Viruses 2020;12 (11) [PubMed]
  • Nijmeijer Bernadien M. Dissemination of HIV-1 and HCV is directed by Langerhans cells: Interplay between receptors 2020. 187p. ISBN 9789493197121. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Geijtenbeek Teunis B. H.; Co-supervisor: Ribeiro Carla M. S.)
  • Cloherty Alexandra P. M., Olmstead Andrea D., Ribeiro Carla M. S., Jean François Hijacking of lipid droplets by hepatitis C, dengue and zika viruses-from viral protein moonlighting to extracellular release International journal of molecular sciences 2020;21 (21):1-18 [PubMed]
  • Nijmeijer Bernadien M., Eder Julia, Langedijk Catharina J. M., Kaptein Tanja M., Meeussen Sofie, Zimmermann Pascale, Ribeiro Carla M. S., Geijtenbeek Teunis B. H. Syndecan 4 Upregulation on Activated Langerhans Cells Counteracts Langerin Restriction to Facilitate Hepatitis C Virus Transmission Frontiers in immunology 2020;11 [PubMed]
  • van Teijlingen Nienke H., Helgers Leanne C., Zijlstra - Willems Esther M., van Hamme John L., Ribeiro Carla M. S., Strijbis Karin, Geijtenbeek Teunis B. H. Vaginal dysbiosis associated-bacteria Megasphaera elsdenii and Prevotella timonensis induce immune activation via dendritic cells Journal of reproductive immunology 2020;138 [PubMed]

2019

  • Nijmeijer Bernadien M, Sarrami-Forooshani Ramin, Steba Gaby S, Schreurs Renée Rce, Koekkoek Sylvie M, Molenkamp Richard, Schinkel Janke, Reiss Peter, Siegenbeek van Heukelom Matthijs L, van der Valk Marc, Ribeiro Carla Ms, Geijtenbeek Teunis Bh HIV-1 exposure and immune activation enhance sexual transmission of Hepatitis C virus by primary Langerhans cells Journal of the International AIDS Society 2019;22 (3):e25268 [PubMed]
  • Hertoghs Nina, Nijmeijer Bernadien M., van Teijlingen Nienke H., Fenton-May Angharad E., Kaptein Tanja M., van Hamme John L., Kappes John C., Kootstra Neeltje A., Hahn Beatrice H., Borrow Persephone, Ribeiro Carla M. S., Geijtenbeek Teunis B. H. Sexually transmitted founder HIV-1 viruses are relatively resistant to Langerhans cell-mediated restriction PLoS ONE 2019;14 (12) [PubMed]

2017

  • Gringhuis Sonja I., Hertoghs Nina, Kaptein Tanja M., Zijlstra-Willems Esther M., Sarrami-Fooroshani Ramin, Sprokholt Joris K., van Teijlingen Nienke H., Kootstra Neeltje A., Booiman Thijs, van Dort Karel A., Ribeiro Carla M. S., Drewniak Agata, Geijtenbeek Teunis B. H. HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3 Nature immunology 2017;18 (2):225-235 [PubMed]
  • Gringhuis Sonja I., Hertoghs Nina, Kaptein Tanja M., Zijlstra-Willems Esther M., Sarrami-Fooroshani Ramin, Sprokholt Joris K., van Teijlingen Nienke H., Kootstra Neeltje A., Booiman Thijs, van Dort Karel A., Ribeiro Carla M. S., Drewniak Agata, Geijtenbeek Teunis B. H. HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3 (vol 18, pg 225, 2017) Nature immunology 2017;18 (4):474 [PubMed]
  • Hertoghs Nina, Geijtenbeek Teunis B. H., Ribeiro Carla M. S. Interplay between HIV-1 innate sensing and restriction in mucosal dendritic cells: balancing defense and viral transmission Current opinion in virology 2017;22:112-119 [PubMed]

2016

  • Ribeiro Carla M. S., Sarrami-Forooshani Ramin, Setiawan Laurentia C., Zijlstra-Willems Esther M., van Hamme John L., Tigchelaar Wikky, van der Wel Nicole N., Kootstra Neeltje A., Gringhuis Sonja I., Geijtenbeek Teunis B. H. Receptor usage dictates HIV-1 restriction by human TRIM5α in dendritic cell subsets Nature 2016;540 (7633):448-452 [PubMed]

2015

  • Ribeiro Carla M. S., Sarrami-Forooshani Ramin, Geijtenbeek Teunis B. H. HIV-1 border patrols: Langerhans cells control antiviral responses and viral transmission Future Virology 2015;10 (11):1231-1243
  • Fink Inge R., Ribeiro Carla M. S., Forlenza Maria, Taverne-Thiele Anja, Rombout Jan H. W. M., Savelkoul Huub F. J., Wiegertjes Geert F. Immune-relevant thrombocytes of common carp undergo parasite-induced nitric oxide-mediated apoptosis Developmental and comparative immunology 2015;50 (2):146-154 [PubMed]

2014

  • van den Berg Linda M., Ribeiro Carla M. S., Zijlstra-Willems Esther M., de Witte Lot, Fluitsma Donna, Tigchelaar Wikky, Everts Vincent, Geijtenbeek Teunis B. H. Caveolin-1 mediated uptake via langerin restricts HIV-1 infection in human Langerhans cells Retrovirology 2014;11 (1):123 [PubMed]
  • Sarrami-Forooshani Ramin, Mesman Annelies W., van Teijlingen Nienke H., Sprokholt Joris K., van der Vlist Michiel, Ribeiro Carla M. S., Geijtenbeek Teunis B. H. Human immature Langerhans cells restrict CXCR4-using HIV-1 transmission Retrovirology 2014;11 (1):52 [PubMed]

2012

  • van der Aa Lieke M., Chadzinska Magdalena, Golbach Lieke A., Ribeiro Carla M. S., Lidy Verburg-van Kemenade B. M. Pro-inflammatory functions of carp CXCL8-like and CXCb chemokines Developmental and comparative immunology 2012;36 (4):741-750 [PubMed]

2011

  • Ribeiro Carla M. S., Bird Steve, Raes Geert, Ghassabeh Gholamreza H., Schijns Virgil E. J. C., Pontes Maria J. S. L., Savelkoul Huub F. J., Wiegertjes Geert F. A Novel Soluble Immune-Type Receptor (SITR) in Teleost Fish: Carp SITR Is Involved in the Nitric Oxide-Mediated Response to a Protozoan Parasite PLoS ONE 2011;6 (1):e15986 [PubMed]

2010

  • Ribeiro Carla M. S., Hermsen Trudi, Taverne-Thiele Anja J., Savelkoul Huub F. J., Wiegertjes Geert F. Evolution of Recognition of Ligands from Gram-Positive Bacteria: Similarities and Differences in the TLR2-Mediated Response between Mammalian Vertebrates and Teleost Fish Journal of immunology (Baltimore, Md. 2010;184 (5):2355-2368 [PubMed]
  • Ribeiro Carla M. S., Schijns Virgil E. J. C. Immunology of vaccine adjuvants Methods in molecular biology (Clifton, N.J.) 2010;626:1-14 [PubMed]
  • Ribeiro Carla M. S., Pontes Maria J. S. L., Bird Steve, Chadzinska Magdalena, Scheer Marleen, Verburg-van Kemenade B. M. Lidy, Savelkoul Huub F. J., Wiegertjes Geert F. Trypanosomiasis-Induced Th17-Like Immune Responses in Carp PLoS ONE 2010;5 (9):e13012 [PubMed]

2008

  • Ruszczyk Aleksandra, Forlenza Maria, Joerink Maaike, Ribeiro Carla M. S., Jurecka Patrycja, Wiegertjes Geert F. Trypanoplasma borreli cysteine proteinase activities support a conservation of function with respect to digestion of host proteins in common carp Developmental and comparative immunology 2008;32 (11):1348-1361 [PubMed]

2006

  • Joerink Maaike, Forlenza Maria, Ribeiro Carla M. S., de Vries Beitske J., Savelkoul Huub F. J., Wiegertjes Geert F. Differential macrophage polarisation during parasitic infections in common carp (Cyprinus carpio L.) Fish & shellfish immunology 2006;21 (5):561-571 [PubMed]
  • Joerink Maaike, Ribeiro Carla M. S., Stet René J. M., Hermsen Trudi, Savelkoul Huub F. J., Wiegertjes Geert F. Head kidney-derived macrophages of common carp (Cyprinus carpio L.) show plasticity and functional polarization upon differential stimulation Journal of immunology (Baltimore, Md. 2006;177 (1):61-69 [PubMed]
back to PhD C.M. Ribeiro