E.G.M. van Baarsen PhD publications

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Publications PhD E.G.M. van Baarsen

Positions
Associate Professor, Assistant Professor, Research Associate
Main activities
Research
Specialisation
Genomics; Immunology; Translational Research; Celbiology; Rheumatology; Stromal cells; Autoimmunity
Focus of research

To ultimately cure or prevent rheumatoid arthritis, it is critical to understand the earliest changes in the immune system that cause RA. Starting from a genome-wide expression profiling approach, this research will delineate the role of stromal cells in bone marrow, lymph node and synovial tissue in arthritis development. Results from these studies will provide innovative drug targets for preventive intervention in pre-clinical RA and identify the immunological processes that initiate RA and possibly other related chronic inflammatory diseases. In addition, molecular profiling of biomaterials is used to identify biomarkers for diagnosis, prognosis and treatment response.

2021

  • Gago da Graça Catarina, van Baarsen Lisa G. M., Mebius Reina E. Tertiary Lymphoid Structures: Diversity in Their Development, Composition, and Role Journal of immunology (Baltimore, Md. 2021;206 (2):273-281 [PubMed]

2020

  • Ramwadhdoebe Tamara Cellular phenotyping of immune cells in lymph node biopsies during health and different phases of rheumatoid arthritis 2020. 165p. ISBN 9789463756822. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Tak Paul. P.; Co-supervisors: van Baarsen Elisabeth. G . M. , Gerlag Danielle. M.)
  • Nadafi Reza, Gago de Graça Catarina, Keuning Eelco D., Koning Jasper J., de Kivit Sander, Konijn Tanja, Henri Sandrine, Borst Jannie, Reijmers Rogier M., van Baarsen Lisa G. M., Mebius Reina E. Lymph Node Stromal Cells Generate Antigen-Specific Regulatory T Cells and Control Autoreactive T and B Cell Responses Cell reports 2020;30 (12):4110-4123.e4 [PubMed]
  • Gerstner Christina, Turcinov Sara, Hensvold Aase H., Chemin Karine, Uchtenhagen Hannes, Ramwadhdoebe Tamara H., Dubnovitsky Anatoly, Kozhukh Genadiy, Rönnblom Lars, Kwok William W., Achour Adnane, Catrina Anca I., van Baarsen Lisa G. M., Malmström Vivianne Multi-HLA class II tetramer analyses of citrulline-reactive T cells and early treatment response in rheumatoid arthritis BMC immunology 2020;21 (1) [PubMed]
  • Nadafi R. Regulation of adaptive immune responses by lymph node stromal cells 2020. 212p. [UvA Dissertations Online] Vrije Universiteit Amsterdam: faculteit Geneeskunde. (Supervisor: Mebius Reina E.; Co-supervisors: van Baarsen Lisa G. M., Reijmers Rogier M.)

2019

  • Levels Maartje J., Fehres Cynthia M., van Baarsen Lisa G. M., van Uden Nathalie O. P., Germar Kristine, O'Toole Tom G., Blijdorp Iris C. J., Semmelink Johanna F., Doorenspleet Marieke E., Bakker Arjen Q., Krasavin Mikhail, Tomilin Alexey, Brouard Sophie, Spits Hergen, Baeten Dominique L. P., Yeremenko Nataliya G. BOB.1 controls memory B-cell fate in the germinal center reaction Journal of autoimmunity 2019;101:131-144 [PubMed]
  • Ramwadhdoebe Tamara H, van Baarsen Lisa G M, Boumans Maria J H, Bruijnen Stefan T G, Safy Mary, Berger Ferco H, Semmelink Johanna F, van der Laken Conny J, Gerlag Danielle M, Thurlings Rogier M, Tak Paul P Effect of rituximab treatment on T and B cell subsets in lymph node biopsies of patients with rheumatoid arthritis Rheumatology (Oxford, England) 2019;58 (6):1075-1085 [PubMed]
  • Karouzakis Emmanuel, Hähnlein Janine, Grasso Cristoforo, Semmelink Johanna F., Tak Paul P., Gerlag Danielle M., Gay Steffen, Ospelt Caroline, van Baarsen Lisa G. M. Molecular characterization of human lymph node stromal cells during the earliest phases of rheumatoid arthritis Frontiers in immunology 2019;10 (AUG) [PubMed]
  • Ramwadhdoebe T H, Ramos M I, Maijer K I, van Lienden K P, Maas M, Gerlag D M, Tak P P, Lebre M C, van Baarsen L G M Myeloid Dendritic Cells Are Enriched in Lymph Node Tissue of Early Rheumatoid Arthritis Patients but not in At Risk Individuals Cells 2019;8 (7) [PubMed]
  • Perucha Esperanza, Melchiotti Rossella, Bibby Jack A, Wu Wing, Frederiksen Klaus Stensgaard, Roberts Ceri A, Hall Zoe, LeFriec Gaelle, Robertson Kevin A, Lavender Paul, Gerwien Jens Gammeltoft, Taams Leonie S, Griffin Julian L, de Rinaldis Emanuele, van Baarsen Lisa G M, Kemper Claudia, Ghazal Peter, Cope Andrew P The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells Nature communications 2019;10 (1):498 [PubMed]

2018

  • Hähnlein Janine S., Ramwadhdoebe Tamara H., Semmelink Johanna F., Choi Ivy Y., Berger Ferco H., Maas Mario, Gerlag Danielle M., Tak Paul P., Geijtenbeek Teunis B. H., van Baarsen Lisa G. M. Distinctive expression of T cell guiding molecules in human autoimmune lymph node stromal cells upon TLR3 triggering Scientific reports 2018;8 (1):1736 [PubMed]
  • Hähnlein Janine S. Human lymph node stromal cells and their role in rheumatoid arthritis 2018. 196p. ISBN 9789463752060. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Tak P. P. , Geijtenbeek T. B. H.; Co-supervisor: van Baarsen E. G. M.)
  • Hähnlein Janine S., Nadafi Reza, de Jong Tineke, Ramwadhdoebe Tamara H., Semmelink Johanna F., Maijer Karen I., Zijlstra Ijsbrand A., Maas Mario, Gerlag Danielle M., Geijtenbeek Teunis B. H., Tak Paul P., Mebius Reina E., van Baarsen Lisa G. M. Impaired lymph node stromal cell function during the earliest phases of rheumatoid arthritis Arthritis research & therapy 2018;20 (1):35 [PubMed]

2017

  • Rodríguez-Carrio Javier, Hähnlein Janine S., Ramwadhdoebe Tamara H., Semmelink Johanna F., Choi Ivy Y., van Lienden Krijn P., Maas Mario, Gerlag Danielle M., Tak Paul P., Geijtenbeek Teunis B. H., van Baarsen Lisa G. M. Brief Report: Altered Innate Lymphoid Cell Subsets in Human Lymph Node Biopsy Specimens Obtained During the At-Risk and Earliest Phases of Rheumatoid Arthritis Arthritis & rheumatology (Hoboken, N.J.) 2017;69 (1):70-76 [PubMed]

2016

  • Ramwadhdoebe Tamara H., Hähnlein Janine, van Kuijk Bo J., Choi Ivy Y., van Boven Leonard J., Gerlag Danielle M., Tak Paul P., van Baarsen Lisa G. Human lymph-node CD8(+) T cells display an altered phenotype during systemic autoimmunity Clinical & translational immunology 2016;5 (4):UNSP e67 [PubMed]
  • Angiolilli Chiara, Grabiec Aleksander M., Ferguson Bradley S., Ospelt Caroline, Malvar Fernandez Beatriz, van Es Inge E., van Baarsen Lisa G. M., Gay Steffen, McKinsey Timothy A., Tak Paul P., Baeten Dominique L., Reedquist Kris A. Inflammatory cytokines epigenetically regulate rheumatoid arthritis fibroblast-like synoviocyte activation by suppressing HDAC5 expression Annals of the rheumatic diseases 2016;75 (2):430-438 [PubMed]
  • Ramwadhdoebe Tamara H., Hähnlein Janine, Maijer Karen I., van Boven Leonard J., Gerlag Danielle M., Tak Paul P., van Baarsen Lisa G. M. Lymph node biopsy analysis reveals an altered immunoregulatory balance already during the at-risk phase of autoantibody positive rheumatoid arthritis European journal of immunology 2016;46 (12):2812-2821 [PubMed]

2015

  • de Hair Maria J. H., Leclerc Patrick, Newsum Elize C., Maijer Karen I., van de Sande Marleen G. H., Ramwadhdoebe Tamara H., van Schaardenburg Dirkjan, van Baarsen Lisa G. M., Korotkova Marina, Gerlag Danielle M., Tak Paul-Peter, Jakobsson Per-Johan Expression of Prostaglandin E2 Enzymes in the Synovium of Arthralgia Patients at Risk of Developing Rheumatoid Arthritis and in Early Arthritis Patients PLoS ONE 2015;10 (7):e0133669 [PubMed]
  • Grabiec Aleksander M., Angiolilli Chiara, Hartkamp Linda M., van Baarsen Lisa G. M., Tak Paul P., Reedquist Kris A. JNK-dependent downregulation of FoxO1 is required to promote the survival of fibroblast-like synoviocytes in rheumatoid arthritis Annals of the rheumatic diseases 2015;74 (9):1763-1771 [PubMed]
  • Noort Ae R., van Zoest Katinka P. M., van Baarsen Lisa G., Maracle Chrissta X., Helder Boy, Papazian Natalie, Romera-Hernandez Monica, Tak Paul P., Cupedo Tom, Tas Sander W. Tertiary Lymphoid Structures in Rheumatoid Arthritis: NF-κB-Inducing Kinase-Positive Endothelial Cells as Central Players American journal of pathology 2015;185 (7):1935-1943 [PubMed]

2014

  • Cantaert Tineke, Van Baarsen Lisa G., Wijbrandts Carla A., Thurlings Rogier M., De Sande Van, Bos Carina, Tineke Kraan Van der Pouw, Verweij Cor L., Tak Paul P., Baeten Dominique L. Corrigendum to Type I interferons have no major influence on humoral autoimmunity in rheumatoid arthritis [Rheumatology 49, 156-166 (2010)] DOI: 10.1093/rheumatology/kep345 Rheumatology (Oxford, England) 2014;53 (4)
  • de Hair M. J. H., van de Sande M. G. H., Ramwadhdoebe T. H., Hansson M., Landewé R., van der Leij C., Maas M., Serre G., van Schaardenburg D., Klareskog L., Gerlag D. M., van Baarsen L. G. M., Tak P. P. Features of the synovium of individuals at risk of developing rheumatoid arthritis: implications for understanding preclinical rheumatoid arthritis Arthritis & rheumatology (Hoboken, N.J.) 2014;66 (3):513-522 [PubMed]
  • Burska A. N., Roget K., Blits M., Soto Gomez L., van de Loo F., Hazelwood L. D., Verweij C. L., Rowe A., Goulielmos G. N., van Baarsen L. G. M., Ponchel F. Gene expression analysis in RA: towards personalized medicine pharmacogenomics journal 2014;14 (2):93-106 [PubMed]
  • van Baarsen Lisa G. M., Lebre Maria C., van der Coelen Dennis, Aarrass Saïda, Tang Man W., Ramwadhdoebe Tamara H., Gerlag Daniëlle M., Tak Paul P. Heterogeneous expression pattern of interleukin 17A (IL-17A), IL-17F and their receptors in synovium of rheumatoid arthritis, psoriatic arthritis and osteoarthritis: possible explanation for nonresponse to anti-IL-17 therapy? Arthritis research & therapy 2014;16 (4):426 [PubMed]
  • de Hair M. J. H., van de Sande M. G. H., Ramwadhdoebe T. H., van der Leij C., Maas M., Hansson M., Klareskog L., Landewé R., Serre G., van Schaardenburg D., Gerlag D. M., van Baarsen L. G. M., Tak P. P. Reply Arthritis & rheumatology (Hoboken, N.J.) 2014;66 (6):1683-1684 [PubMed]

2013

  • de Hair Marjolein J. H. Clinical studies and tissues analyses in the earliest phases of rheumatoid arthritis: in search of the transition from being at risk to having clinically apparent disease 2013. 174p. ISBN 9789461822536. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Tak P. P.; Co-supervisor: van Baarsen E. G. M.)
  • de Hair Maria J. H., Landewé Robert B. M., van de Sande Marleen G. H., van Schaardenburg Dirkjan, van Baarsen Lisa G. M., Gerlag Danielle M., Tak Paul P. Smoking and overweight determine the likelihood of developing rheumatoid arthritis Annals of the rheumatic diseases 2013;72 (10):1654-1658 [PubMed]
  • van Baarsen L. G. M., de Hair M. J. H., Ramwadhdoebe T. H., Zijlstra I. J. A. J., Maas M., Gerlag D. M., Tak P. P. The cellular composition of lymph nodes in the earliest phase of inflammatory arthritis Annals of the rheumatic diseases 2013;72 (8):1420-1424 [PubMed]

2012

  • Gerlag Danielle M., Raza Karim, van Baarsen Lisa G. M., Brouwer Elisabeth, Buckley Christopher D., Burmester Gerd R., Gabay Cem, Catrina Anca I., Cope Andrew P., Cornelis François, Dahlqvist Solbritt Rantapää, Emery Paul, Eyre Stephen, Finckh Axel, Gay Steffen, Hazes Johanna M., van der Helm-van Mil Annette, Huizinga Tom W. J., Klareskog Lars, Kvien Tore K., Lewis Cathryn, Machold Klaus P., Rönnelid Johan, van Schaardenburg Dirkjan, Schett Georg, Smolen Josef S., Thomas Sue, Worthington Jane, Tak Paul P. EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: report from the Study Group for Risk Factors for Rheumatoid Arthritis Annals of the rheumatic diseases 2012;71 (5):638-641 [PubMed]
  • de Launay Daphne, van de Sande Marleen G. H., de Hair Maria J. H., Grabiec Aleksander M., van de Sande Gijs P. M., Lehmann K. Aad, Wijbrandts Carla A., van Baarsen Lisa G. M., Gerlag Danielle M., Tak Paul P., Reedquist Kris A. Selective involvement of ERK and JNK mitogen-activated protein kinases in early rheumatoid arthritis (1987 ACR criteria compared to 2010 ACR/EULAR criteria): a prospective study aimed at identification of diagnostic and prognostic biomarkers as well as therapeutic targets Annals of the rheumatic diseases 2012;71 (3):415-423 [PubMed]

2011

  • van de Sande Marleen G. H., Gerlag Danielle M., Lodde Beatrijs M., van Baarsen Lisa G. M., Alivernini Stefano, Codullo Veronica, Felea Ioana, Vieira-Sousa Elsa, Fearon Ursula, Reece Richard, Montecucco Carlomaurizio, Veale Douglas J., Pitzalis Costantino, Emery Paul, Klareskog Lars, McInnes Iain B., Tak Paul P. Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials Annals of the rheumatic diseases 2011;70 (3):423-427 [PubMed]
  • Corr Maripat, Boyle David L., Ronacher Lisa M., Lew Brian R., van Baarsen Lisa G., Tak Paul P., Firestein Gary S. Interleukin 1 receptor antagonist mediates the beneficial effects of systemic interferon beta in mice: implications for rheumatoid arthritis Annals of the rheumatic diseases 2011;70 (5):858-863 [PubMed]
  • Van Baarsen Lisa G.M., Lodde Beatrijs M., Tak Paul P. Kan therapie op maat realiteit worden? Nederlands tijdschrift voor geneeskunde 2011;155 (30-31):1330-1332
  • van Baarsen Lisa G. M., Lodde Beatrijs M., Tak Paul P. Kan therapie op maat realiteit worden? Nederlands tijdschrift voor geneeskunde 2011;155 (30-31):A3569 [PubMed]

2010

  • van Baarsen Lisa G. M., Bos Wouter H., Rustenburg François, van der Pouw Kraan Tineke C. T. M., Wolbink Gerrit Jan J., Dijkmans Ben A. C., van Schaardenburg Dirkjan, Verweij Cornelis L. Gene expression profiling in autoantibody-positive patients with arthralgia predicts development of arthritis Arthritis and rheumatism 2010;62 (3):694-704 [PubMed]
  • van Baarsen L. G. M., Wijbrandts C. A., Gerlag D. M., Rustenburg F., van der Pouw Kraan T. C. T. M., Dijkmans B. A. C., Tak P. P., Verweij C. L. Pharmacogenomics of infliximab treatment using peripheral blood cells of patients with rheumatoid arthritis Genes and immunity 2010;11 (8):622-629 [PubMed]
  • van Baarsen Lisa G. M., Wijbrandts Carla A., Rustenburg Francois, Cantaert Tineke, van der Pouw Kraan Tineke C. T. M., Baeten Dominique L., Dijkmans Ben A. C., Tak Paul P., Verweij Cornelis L. Regulation of interferon response gene activity during infliximab treatment in rheumatoid arthritis is associated with clinical response to treatment Arthritis research & therapy 2010;12 (1):R11 [PubMed]
  • Thurlings Rogier M., Boumans Marie, Tekstra Janneke, van Roon Joel A., Vos Koen, van Westing Daisy Marie, van Baarsen Lisa G., Bos Carina, Kirou Kyriakos A., Gerlag Danielle M., Crow Mary K., Bijlsma Johannes W., Verweij Cornelis L., Tak Paul P. Relationship between the type I interferon signature and the response to rituximab in rheumatoid arthritis patients Arthritis and rheumatism 2010;62 (12):3607-3614 [PubMed]
  • van Baarsen L. G. M. Reumatoïde artritis: naar planning van behandeling op individueel niveau? Nederlands tijdschrift voor reumatologie 2010;2010 (1):11-14
  • van Baarsen Lisa G. M., Wijbrandts Carla A., Timmer Trieneke C. G., van der Pouw Kraan Tineke C. T. M., Tak Paul P., Verweij Cornelis L. Synovial tissue heterogeneity in rheumatoid arthritis in relation to disease activity and biomarkers in peripheral blood Arthritis and rheumatism 2010;62 (6):1602-1607 [PubMed]
  • Lindberg Johan, Wijbrandts Carla A., van Baarsen Lisa G., Nader Gustavo, Klareskog Lars, Catrina Anca, Thurlings Rogier, Vervoordeldonk Margriet, Lundeberg Joakim, Tak Paul P. The Gene Expression Profile in the Synovium as a Predictor of the Clinical Response to Infliximab Treatment in Rheumatoid Arthritis PLoS ONE 2010;5 (6):e11310 [PubMed]
  • Cantaert Tineke, Baeten Dominique, Tak Paul P., van Baarsen Lisa G. M. Type I IFN and TNFα cross-regulation in immune-mediated inflammatory disease: basic concepts and clinical relevance Arthritis research & therapy 2010;12 (5):219 [PubMed]
  • Cantaert Tineke, van Baarsen Lisa G., Wijbrandts Carla A., Thurlings Rogier M., van de Sande Marleen G., Bos Carina, Kraan van der Pouw Tineke, Verweij Cor L., Tak Paul P., Baeten Dominique L. Type I interferons have no major influence on humoral autoimmunity in rheumatoid arthritis Rheumatology (Oxford, England) 2010;49 (1):156-166 [PubMed]

2009

  • Bos C. L., van Baarsen L. G. M., Timmer T. C. G., Overbeek M. J., Basoski N. M., Rustenburg F., Baggen J. M. C., Thiesen H. J., Dijkmans B. A. C., van der Pouw Kraan T. C. T. M., Voskuyl A. E., Verweij C. L. Molecular subtypes of systemic sclerosis in association with anti-centromere antibodies and digital ulcers Genes and immunity 2009;10 (3):210-218 [PubMed]
  • Vosslamber Saskia, van Baarsen Lisa G. M., Verweij Cornelis L. Pharmacogenomics of IFN-beta in multiple sclerosis: towards a personalized medicine approach Pharmacogenomics 2009;10 (1):97-108 [PubMed]
  • van Baarsen Lisa G. M., Bos Carina L., van der Pouw Kraan Tineke C. T. M., Verweij Cornelis L. Transcription profiling of rheumatic diseases Arthritis research & therapy 2009;11 (1):207 [PubMed]

2008

  • van der Pouw Kraan T. C. T. M., van Baarsen L. G. M., Wijbrandts C. A., Voskuyl A. E., Rustenburg F., Baggen J. M., Dijkmans B. A. C., Tak P. P., Verweij C. L. Expression of a pathogen-response program in peripheral blood cells defines a subgroup of rheumatoid arthritis patients Genes and immunity 2008;9 (1):16-22 [PubMed]
  • van Baarsen Lisa G. M., Vosslamber Saskia, Tijssen Marianne, Baggen Josefien M. C., van der Voort Laura F., Killestein Joep, van der Pouw Kraan Tineke C. T. M., Polman Chris H., Verweij Cornelis L. Pharmacogenomics of interferon-beta therapy in multiple sclerosis: baseline IFN signature determines pharmacological differences between patients PLoS ONE 2008;3 (4):e1927 [PubMed]
  • van der Pouw Kraan T. C., Wijbrandts C. A., van Baarsen L. G., Rustenburg F., Baggen J. M., Verweij C. L., Tak P. P. Responsiveness to anti-tumour necrosis factor alpha therapy is related to pre-treatment tissue inflammation levels in rheumatoid arthritis patients Annals of the rheumatic diseases 2008;67 (4):563-566 [PubMed]

2007

  • van der Pouw Kraan Tineke C. T. M., van Baarsen Lisa G. M., Rustenburg François, Baltus Belinda, Fero Mike, Verweij Cornelis L. Gene expression profiling in rheumatology Methods in molecular medicine 2007;136:305-327 [PubMed]
  • Lebre Maria C., van der Aar Angelic M. G., van Baarsen Lisa, van Capel Toni M. M., Schuitemaker Joost H. N., Kapsenberg Martien L., de Jong Esther C. Human keratinocytes express functional Toll-like receptor 3, 4, 5, and 9 Journal of investigative dermatology 2007;127 (2):331-341 [PubMed]
  • van der Pouw Kraan T. C. T. M., Wijbrandts C. A., van Baarsen L. G. M., Voskuyl A. E., Rustenburg F., Baggen J. M., Ibrahim S. M., Fero M., Dijkmans B. A. C., Tak P. P., Verweij C. L. Rheumatoid arthritis subtypes identified by genomic profiling of peripheral blood cells: assignment of a type I interferon signature in a subpopulation of patients Annals of the rheumatic diseases 2007;66 (8):1008-1014 [PubMed]

2006

  • van Baarsen Lisa G. M., van der Pouw-Kraan Tineke C. T. M., Verweij Cornelis L. A genomic view of subtypes in rheumatoid arthritis: towards personalized medicine Future rheumatology 2006;1 (3):311-322
  • van Baarsen L. G. M., van der Pouw Kraan T. C. T. M., Kragt J. J., Baggen J. M. C., Rustenburg F., Hooper T., Meilof J. F., Fero M. J., Dijkstra C. D., Polman C. H., Verweij C. L. A subtype of multiple sclerosis defined by an activated immune defense program Genes and immunity 2006;7 (6):522-531 [PubMed]

2005

  • Kasperkovitz Pia V., Timmer Trieneke C. G., Smeets Tom J., Verbeet Nicolette L., Tak Paul P., van Baarsen Lisa G. M., Baltus Belinda, Huizinga Tom W. J., Pieterman Elsbet, Fero Mike, Firestein Gary S., van der Pouw Kraan Tineke C. T. M., Verweij Cornelis L. Fibroblast-like synoviocytes derived from patients with rheumatoid arthritis show the imprint of synovial tissue heterogeneity - Evidence of a link between an increased myofibroblast-like phenotype and high-inflammation synovitis Arthritis and rheumatism 2005;52 (2):430-441 [PubMed]

2003

  • Bayley Jean-Pierre, van Rietschoten Johanna G. I., Bakker Aleida M., van Baarsen Lisa, Kaijzel Eric L., Wierenga Eddy A., van der Pouw Kraan Tineke C. T. M., Huizinga Tom W. J., Verweij Cornelis L. Allele-specific expression of the IL-1 alpha gene in human CD4+ T cell clones Journal of immunology (Baltimore, Md. 2003;171 (5):2349-2353 [PubMed]