H. Klumpen MD PhD publications

2021

• van Doorn Diederick J., Takkenberg Robert Bart, Klümpen Heinz-Josef Immune checkpoint inhibitors in hepatocellular carcinoma: An overview Pharmaceuticals 2021;14 (1):1-23 [PubMed]
• Nooijen Lynn E., Swijnenburg Rutger-Jan, Klümpen Heinz-Josef, Verheij Joanne, Kazemier Geert, van Gulik Thomas M., Erdmann Joris I. Surgical Therapy for Perihilar Cholangiocarcinoma: State of the Art Visceral medicine 2021

2020

• Belkouz A., Wilmink J. W., Haj Mohammad N., Hagendoorn J., de Vos-Geelen J., Dejong C. H. C., Homs M. Y. V., Groot Koerkamp B., van Gulik T. M., van Oijen M. G. H., Punt C. J. A., Klümpen H. Advances in adjuvant therapy of biliary tract cancer: an overview of current clinical evidence based on phase II and III trials Critical reviews in oncology/hematology 2020;151 [PubMed]
• de Ridder Mischa, Nieveen van Dijkum Els, Engelsman Anton, Kapiteijn Ellen, Klümpen Heinz-Josef, Rasch Coen R. N. Anaplastic thyroid carcinoma: a nationwide cohort study on incidence, treatment and survival in the Netherlands over 3 decades European journal of endocrinology / European Federation of Endocrine Societies 2020;183 (2):203-209 [PubMed]
• Roos Eva, Strijker Marin, Franken Lotte C., Busch Olivier R., van Hooft Jeanin E., Klümpen Heinz-Josef, van Laarhoven Hanneke W., Wilmink Johanna W., Verheij Joanne, van Gulik Thomas M., Besselink Marc G. Comparison of short- and long-term outcomes between anatomical subtypes of resected biliary tract cancer in a Western high-volume center HPB: The official journal of the International Hepato Pancreato Biliary Association 2020;22 (3):405-414 [PubMed]
• Ettaieb Madeleine H. T., van Kuijk Sander M. J., de Wit-Pastoors Annelies, Feelders Richard A., Corssmit Eleonora P. M., Eekhoff Elisabeth M. W., van der Valk Paul, Timmers Henri J. L. M., Kerstens Michiel N., Klümpen Heinz-Josef, Leeuwaarde van Rachel S., Havekes Bas, Haak Harm R. Development and internal validation of a multivariable prediction model for adrenocortical-carcinoma-specific mortality Cancers 2020;12 (9):1-16 [PubMed]
• Belkouz Ali, de Vos-Geelen Judith, Mathôt Ron A. A., Eskens Ferry A. L. M., van Gulik Thomas M., van Oijen Martijn G. H., Punt Cornelis J. A., Wilmink Johanna W., Klümpen Heinz-Josef Efficacy and safety of FOLFIRINOX as salvage treatment in advanced biliary tract cancer: an open-label, single arm, phase 2 trial British journal of cancer 2020;122 (5):634-639 [PubMed]
• Belkouz Ali, Nooijen Lynn E., Riady Hanae, Franken Lotte C., van Oijen Martijn G. H., Punt Cornelis J. A., Erdmann Joris I., Klümpen Heinz-Josef Efficacy and safety of systemic induction therapy in initially unresectable locally advanced intrahepatic and perihilar cholangiocarcinoma: A systematic review Cancer treatment reviews 2020;91 [PubMed]
• Kuiper Teaco, van Oijen M. G. H., van Velthuysen M. F., van Lelyveld N., van Leerdam M. E., Vleggaar F. D., Klümpen H. J. Endoscopically removed rectal NETs: a nationwide cohort study International journal of colorectal disease 2020 [PubMed]
• Merola Elettra, Zandee Wouter, de Mestier Louis, Klümpen Heinz Josef, Makulik Karolina, Geboes Karen, van Velthuysen Marie Louise, Couvelard Anne, Cros J. rôme, van Eeden Susanne, Hoorens Anne, Stephenson Timothy, Zajȩcki W., de Herder Wouter, Munir Alia Histopathological Revision for Gastroenteropancreatic Neuroendocrine Neoplasms in Expert Centers: Does It Make the Difference? Neuroendocrinology 2020;111 (1-2):170-177 [PubMed]
• Labeur Tim A., Berhane Sarah, Edeline Julien, Blanc Jean-Frederic, Bettinger Dominik, Meyer Tim, van Vugt Jeroen L. A., ten Cate David W. G., de Man Robert A., Eskens Ferry A. L. M., Cucchetti Alessandro, Bonnett Laura J., van Delden Otto M., Klümpen Heinz-Josef, Takkenberg R. Bart, Johnson Philip J. Improved survival prediction and comparison of prognostic models for patients with hepatocellular carcinoma treated with sorafenib Liver international 2020;40 (1):215-228 [PubMed]
• Labeur Tim A. Predicting outcomes and personalizing treatment in hepatocellular carcinoma 2020. 337p. ISBN 9789402821345. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van Delden Otto M.; Co-supervisors: Takkenberg Bart B., Klumpen Heinz-Josef)
• Labeur Tim A., Achterbergh Roos, Takkenberg Bart, van Delden Otto, Mathôt Ron, Klümpen Heinz-Josef Sorafenib for Patients with Hepatocellular Carcinoma and Child-Pugh B Liver Cirrhosis: Lessons Learned from a Terminated Study oncologist 2020;25 (9):e1274-e1279 [PubMed]
• Kranendonk Mariëtte E. G., Hackeng Wenzel M., Offerhaus G. Johan A., Morsink Folkert H. M., Jonges Geertruida N., Groenewegen Gerard, Krijtenburg Pieter-Jaap, Klümpen Heinz-Josef, de Leng Wendy W. J., Looijenga Leendert H. J., Brosens Lodewijk A. A. The decisive role of molecular pathology in presumed somatic metastases of type II testicular germ cell tumors: report of 2 cases Diagnostic pathology 2020;15 (1):99 [PubMed]
• Labeur Tim A., Cieslak Kasia P., van Gulik Thomas M., Takkenberg R. Bart, van der Velden Sandra, Lam Marnix G. E. H., Klümpen Heinz-Josef, Bennink Roel J., van Delden Otto M. The utility of 99mTc-mebrofenin hepatobiliary scintigraphy with SPECT/CT for selective internal radiation therapy in hepatocellular carcinoma Nuclear medicine communications 2020;41 (8):740-749 [PubMed]
• Labeur Tim A., Hofsink Quincy, Takkenberg R. Bart, van Delden Otto M., Mathôt Ron A. A., Schinner Regina, Malfertheiner Peter, Amthauer Holger, Schütte Kerstin, Basu Bristi, Kuhl Christiane, Mayerle Julia, Ricke Jens, Klümpen Heinz-Josef The value of sorafenib trough levels in patients with advanced hepatocellular carcinoma–a substudy of the SORAMIC trial Acta oncologica (Stockholm, Sweden) 2020;59 (9):1028-1035 [PubMed]
• Reinders Margot T. M., van Meer Suzanne, Burgmans Mark C., de Jong Koert P., Klümpen Heinz-Josef, de Man Robert A., Ramsoekh D. (Sandjai), Sprengers Dave, Tjwa Eric T. T. L., de Vos-Geelen Judith, van Erpecum Karel J., van der Geest Lydia G. M. Trends in incidence, diagnosis, treatment and survival of hepatocellular carcinoma in a low-incidence country: Data from the Netherlands in the period 2009–2016 European journal of cancer (Oxford, England 2020;137:214-223 [PubMed]

2019

• Kruizinga Renske, Scherer-Rath Michael, Schilderman Johannes B. AM, Hartog Iris D., van der Loos Jacoba P. M., Kotzé Hantie P., Westermann Anneke M., Klümpen Heinz-Josef, Kortekaas Francesco, Grootscholten Cecile, Bossink Frans, Schrama Jolanda, van de Vrande Willem, Schrama Natascha A. WP, Blokland Willem, de Vos Filip Y. FL, Kuin Annemieke, Meijer Wim G., van Oijen Martijn G. H., Sprangers Mirjam A. G., van Laarhoven Hanneke W. M. An assisted structured reflection on life events and life goals in advanced cancer patients: Outcomes of a randomized controlled trial (Life InSight Application (LISA) study) Palliative medicine 2019;33 (2):221-231 [PubMed]
• Labeur Tim A., van Vugt Jeroen L. A., ten Cate David W. G., Takkenberg R. Bart, Ijzermans Jan N. M., Groot Koerkamp Bas, de Man Robert A., van Delden Otto M., Eskens Ferry A. L. M., Klümpen Heinz-Josef Body Composition Is an Independent Predictor of Outcome in Patients with Hepatocellular Carcinoma Treated with Sorafenib Liver Cancer 2019;8 (4):255-270 [PubMed]
• Labeur Tim A., Takkenberg R. Bart, Klümpen Heinz-Josef, van Delden Otto M. Correction to: Reason of Discontinuation After Transarterial Chemoembolization Influences Survival in Patients with Hepatocellular Carcinoma (CardioVascular and Interventional Radiology, (2018), 10.1007/s00270-018-2118-6) Cardiovascular and interventional radiology 2019;42 (3):484-484 [PubMed]
• Roos E., Soer E. C., Klompmaker S., Meijer L. L., Besselink M. G., Giovannetti E., Heger M., Kazemier G., Klümpen H. J., Takkenberg R. B., Wilmink H., Würdinger T., Dijk F., van Gulik T. M., Verheij J., van de Vijver M. J. Crossing borders: A systematic review with quantitative analysis of genetic mutations of carcinomas of the biliary tract Critical reviews in oncology/hematology 2019;140:8-16 [PubMed]
• van Nierop F. Samuel, Meessen Emma C. E., Nelissen Kyra G. M., Achterbergh Roos, Lammers Laureen A., Vaz Frédéric M., Mathôt Ron A. A., Klümpen Heinz-Josef, Olde Damink Steven W., Schaap Frank G., Romijn Johannes A., Kemper E. Marleen, Soeters Maarten R. Differential effects of a 40-hour fast and bile acid supplementation on human GLP-1 and FGF19 responses American journal of physiology. Endocrinology and metabolism 2019;317 (3):E494-E502 [PubMed]
• Labeur Tim A., Runge Jurgen H., Klompenhouwer Elisabeth G., Klümpen Heinz-Josef, Takkenberg R. Bart, van Delden Otto M. Diffusion-weighted imaging of hepatocellular carcinoma before and after transarterial chemoembolization: role in survival prediction and response evaluation ABDOMINAL RADIOLOGY 2019;44 (8):2740-2750 [PubMed]
• Achterbergh R., Lammers L. A., Kuijsten L., Klümpen H. J., Mathôt R. A. A., Romijn J. A. Effects of nutritional status on acetaminophen measurement and exposure CLINICAL TOXICOLOGY 2019;57 (1):42-49 [PubMed]
• van Lierop Antoon H, Bisschop Peter H, Boelen Anita, van Eeden Susanne, Engelman Anton F, Nieveen van Dijkum Elisabeth J, Klümpen Heinz-Josef Hypercalcaemia due to a calcitriol-producing neuroendocrine tumour Journal of surgical case reports 2019;2019 (12):rjz346 [PubMed]
• Ricke Jens, Klümpen Heinz Josef, Amthauer Holger, Bargellini Irene, Bartenstein Peter, de Toni Enrico N., Gasbarrini Antonio, Pech Maciej, Peck-Radosavljevic Markus, Popovič Peter, Rosmorduc Olivier, Schott Eckart, Seidensticker Max, Verslype Chris, Sangro Bruno, Malfertheiner Peter Impact of combined selective internal radiation therapy and sorafenib on survival in advanced hepatocellular carcinoma Journal of hepatology 2019;71 (6):1164–1174 [PubMed]
• Roos Eva, Franken Lotte C., Soer Eline C., van Hooft Jeanin E., Takkenberg R. Bart, Klümpen Heinz-Josef, Wilmink Johanna W., van de Vijver Marc J., van Gulik Thomas M., Verheij Joanne Lost in translation: confusion on resection and dissection planes hampers the interpretation of pathology reports for perihilar cholangiocarcinoma Virchows Archiv 2019;475 (4):435-443 [PubMed]
• Achterbergh Roos Nutritional conditioning: The effect of a short-term high fat diet on hepatic drug metabolism 2019. 145p. ISBN 9789402816044. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Romijn J. A. , Mathot R. A. A.; Co-supervisor: Klumpen H. J.)
• Belkouz Ali, Labeur Tim A., Dierks Joeri, Dijk Frederike, van Oijen Martijn G. H., Verheij Joanne, van Gulik Thomas M., van de Vijver Marc J., Wilmink Hanneke, Punt Cornelis J. A., Klümpen Heinz-Josef Prognostic immunohistochemical biomarkers of chemotherapy efficacy in biliary tract cancer: A systematic review and meta-analysis Critical reviews in oncology/hematology 2019;141:82-94 [PubMed]
• Labeur Tim A., Takkenberg R. Bart, Klümpen Heinz-Josef, van Delden Otto M. Reason of Discontinuation After Transarterial Chemoembolization Influences Survival in Patients with Hepatocellular Carcinoma Cardiovascular and interventional radiology 2019;42 (2):230-238 [PubMed]
• Groot H. J., Lubberts S., de Wit R., Witjes J. A., Kerst J. M., de Jong I. J., Groenewegen G., van den Eertwegh A. J. M., Poortmans P. M., Klümpen H. J., van den Berg H. A., Smilde T. J., Vanneste B. G. L., Aarts M. J., Incrocci L., van den Bergh A. C. M., Jozwiak K., van den Belt-Dusebout A. W., Horenblas S., Gietema J. A., van Leeuwen F. E., Schaapveld M. Re: Risk of solid cancer after treatment of testicular germ cell cancer in the platinum era Journal of urology 2019;201 (3):445 [PubMed]
• Rassam Fadi, Olthof Pim B., Takkenberg Bart R., Beuers Ulrich, Klümpen Heinz-Josef, Bennink Roelof J., van Lienden Krijn P., Besselink Marc G., Busch Olivier R., Verheij Joanne, van Gulik Thomas M. Scintigraphic liver function and transient elastography in the assessment of patients with resectable hepatocellular carcinoma HPB: The official journal of the International Hepato Pancreato Biliary Association 2019;21 (5):626-635 [PubMed]
• Strijker Marin, Belkouz Ali, van der Geest Lydia G., van Gulik Thomas M., van Hooft Jeanin E., de Meijer Vincent E., Haj Mohammad Nadia, de Reuver Philip R., Verheij Joanne, de Vos-Geelen Judith, Wilmink Johanna W., Groot Koerkamp Bas, Klümpen Heinz Josef, Besselink Marc G. Treatment and survival of resected and unresected distal cholangiocarcinoma: a nationwide study Acta oncologica (Stockholm, Sweden) 2019;58 (7):1048-1055 [PubMed]
• Kaçmaz Enes, Heidsma Charlotte M, Besselink Marc G H, Dreijerink Koen M A, Klümpen Heinz-Josef, Nieveen van Dijkum Elisabeth J M, Engelsman Anton F Treatment of Liver Metastases from Midgut Neuroendocrine Tumours: A Systematic Review and Meta-Analysis Journal of clinical medicine 2019;8 (3) [PubMed]

2018

• Genc C. G., Klümpen H. J., van Oijen M. G. H., van Eijck C. H. J., Nieveen van Dijkum E. J. M. A Nationwide Population-Based Study on the Survival of Patients with Pancreatic Neuroendocrine Tumors in The Netherlands World journal of surgery 2018;42 (2):490-497 [PubMed]
• Molenaar Remco J., van de Venne Tim, Weterman Mariëtte J., Mathot Ron A., Klümpen Heinz-Josef, Richel Dick J., Wilmink Johanna W. A phase Ib study of everolimus combined with metformin for patients with advanced cancer Investigational new drugs 2018;36 (1):53-61 [PubMed]
• Labeur Tim A., ten Cate David W. G., Bart Takkenberg R., Azahaf Hicham, van Oijen Martijn G. H., van Delden Otto M., de Man Robert A., van Vugt Jeroen L. A., IJzermans Jan N. M., Eskens Ferry A. L. M., Klümpen Heinz-Josef Are we SHARP enough? The importance of adequate patient selection in sorafenib treatment for hepatocellular carcinoma Acta oncologica (Stockholm, Sweden) 2018;57 (11):1467-1474 [PubMed]
• Abou-Alfa Ghassan K., Meyer Tim, Cheng Ann-Lii, el-Khoueiry Anthony B., Rimassa Lorenza, Ryoo Baek-Yeol, Cicin Irfan, Merle Philippe, Chen YenHsun, Park Joong-Won, Blanc Jean-Frederic, Bolondi Luigi, Klümpen Heinz-Josef, Chan Stephen L., Zagonel Vittorina, Pressiani Tiziana, Ryu Min-Hee, Venook Alan P., Hessel Colin, Borgman-Hagey Anne E., Schwab Gisela, Kelley Robin K. Cabozantinib in patients with advanced and progressing hepatocellular carcinoma New England journal of medicine 2018;379 (1):54-63 [PubMed]
• de Brabander Justin, Eskens Ferry A. L. M., Korsse Susanne E., Dekker Evelien, Dewint Pieter, van Leerdam Monique E., van Eeden Susanne, Klümpen Heinz-Josef Chemoprevention in Patients with Peutz-Jeghers Syndrome: Lessons Learned oncologist 2018;23 (4):399-e33 [PubMed]
• Genç Cansu G., Jilesen Anneke P. J., Nieveen van Dijkum Els J. M., Klümpen Heinz-Josef, van Eijck Casper H. J., Drozdov Ignat, Malczewska Anna, Kidd Mark, Modlin Irvin Measurement of circulating transcript levels (NETest) to detect disease recurrence and improve follow-up after curative surgical resection of well-differentiated pancreatic neuroendocrine tumors Journal of surgical oncology 2018;118 (1):37-48 [PubMed]
• Rassam F., Roos E., van Lienden K. P., van Hooft J. E., Klümpen H. J., van Tienhoven G., Bennink R. J., Engelbrecht M. R., Schoorlemmer A., Beuers U. H. W., Verheij J., Besselink M. G., Busch O. R., van Gulik T. M. Modern work-up and extended resection in perihilar cholangiocarcinoma: the AMC experience Langenbeck s archives of surgery / Deutsche Gesellschaft fur Chirurgie 2018;403 (3):289-307 [PubMed]
• Schuller Yvonne, Biegstraaten Marieke, Hollak Carla E. M., Klümpen Heinz-Josef, Gispen-de Wied Christine C., Stoyanova-Beninska Violeta Oncologic orphan drugs approved in the EU - Do clinical trial data correspond with real-world effectiveness? Orphanet journal of rare diseases 2018;13 (1) [PubMed]
• Salazar Ramon, Garcia-Carbonero Rocio, Libutti Steven K., Hendifar Andrew E., Custodio Ana, Guimbaud Rosine, Lombard-Bohas Catherine, Ricci Sergio, Klümpen Heinz-Josef, Capdevila Jaume, Reed Nicholas, Walenkamp Annemiek, Grande Enrique, Safina Sufiya, Meyer Tim, Kong Oliver, Salomon Herve, Tavorath Ranjana, Yao James C. Phase II Study of BEZ235 versus Everolimus in Patients with Mammalian Target of Rapamycin Inhibitor-Naïve Advanced Pancreatic Neuroendocrine Tumors oncologist 2018;23 (7):766 [PubMed]
• Genç C. G., Falconi M., Partelli S., Muffatti F., van Eeden S., Doglioni C., Klümpen H. J., van Eijck C. H. J., Nieveen van Dijkum E. J. M. Recurrence of Pancreatic Neuroendocrine Tumors and Survival Predicted by Ki67 Annals of surgical oncology 2018;25 (8):2467-2474 [PubMed]
• Groot Harmke J., Lubberts Sjoukje, de Wit Ronald, Witjes Johannes A., Kerst Jan Martijn, de Jong Igle J., Groenewegen Gerard, van den Eertwegh Alfons J. M., Poortmans Philip M., Klümpen Heinz-Josef, van den Berg Hetty A., Smilde Tineke J., Vanneste Ben G. L., Aarts Maureen J., Incrocci Luca, van den Bergh Alfons C. M., Jóźwiak Katarzyna, van den Belt-Dusebout Alexandra W., Horenblas Simon, Gietema Jourik A., van Leeuwen Flora E., Schaapveld Michael Risk of solid cancer after treatment of testicular germ cell cancer in the platinum era Journal of clinical oncology 2018;36 (24):2504-2513 [PubMed]
• Genç Cansu G., Klümpen Heinz-Josef, Denecke Timm, Wiedenmann Bertram, Pavel Marianne Successful treatment of high-grade pancreatic neuroendocrine neoplasms with everolimus Acta oncologica (Stockholm, Sweden) 2018;57 (5):686-688 [PubMed]
• Dierks J., Gaspersz M. P., Belkouz A., van Vugt J. L. A., Coelen R. J. S., de Groot J. W. B., ten Tije A. J., Meijer W. G., Pruijt J. F. M., van Voorthuizen T., van Spronsen D. J., Rentinck M., ten Oever D., Smit J. M., Otten H. M., van Gulik T. M., Wilmink J. W., Groot Koerkamp B., Klümpen H. Translating the ABC-02 trial into daily practice: outcome of palliative treatment in patients with unresectable biliary tract cancer treated with gemcitabine and cisplatin Acta oncologica (Stockholm, Sweden) 2018;57 (6):807-812 [PubMed]
• de Bree Karel, Westermann Anneke M., Klümpen Heinz-Josef, Verheij Joanne, Phoa Saffire S. K. S., Oomen Matthijs, van Gulik Thomas M. Two Cases of Hepatoblastoma in Young Adults Journal of adolescent and young adult oncology 2018;7 (3):404-408 [PubMed]

2017

• Coelen Robert J. S., Vogel Jantien A., Vroomen Laurien G. P. H., Roos Eva, Busch Olivier R. C., van Delden Otto M., van Delft Foke, Heger Michal, van Hooft Jeanin E., Kazemier Geert, Klümpen Heinz-Josef, van Lienden Krijn P., Rauws Erik A. J., Scheffer Hester J., Verheul Henk M., de Vries Jan, Wilmink Johanna W., Zonderhuis Barbara M., Besselink Marc G., van Gulik Thomas M., Meijerink Martijn R. Ablation with irreversible electroporation in patients with advanced perihilar cholangiocarcinoma (ALPACA): a multicentre phase I/II feasibility study protocol BMJ open 2017;7 (9):e015810 [PubMed]
• Cirkel Geert A., Hamberg Paul, Sleijfer Stefan, Loosveld Olaf J. L., Dercksen M. Wouter, Los Maartje, Polee Marco B., van den Berkmortel Franchette, Aarts Maureen J., Beerepoot Laurens V., Groenewegen Gerard, Lolkema Martijn P., Tascilar Metin, Portielje Johanna E. A., Peters Frank P. J., Klümpen Heinz-Josef, van der Noort Vincent, Haanen John B. A. G., Voest Emile E. Alternating Treatment With Pazopanib and Everolimus vs Continuous Pazopanib to Delay Disease Progression in Patients With Metastatic Clear Cell Renal Cell Cancer The ROPETAR Randomized Clinical Trial JAMA oncology 2017;3 (4):501-508 [PubMed]
• de Hosson L. D., Veenendaal L. M. van, Schuller Y., Zandee W. T., de Herder W. W., Tesselaar M. E. T., Klümpen H. J., Walenkamp A. M. E. Clinical benefit of systemic treatment in patients with advanced pancreatic and gastrointestinal neuroendocrine tumours according to ESMO-MCBS and ASCO framework Annals of oncology 2017;28 (12):3022-3027 [PubMed]
• Coelen Robert Js, Huiskens Joost, Olthof Pim B., Roos Eva, Wiggers Jimme K., Schoorlemmer Annuska, van Delden Otto M., Klümpen Heinz-Josef, Rauws Erik A. J., van Gulik Thomas M. Compliance with evidence-based multidisciplinary guidelines on perihilar cholangiocarcinoma United European gastroenterology journal 2017;5 (4):519-526 [PubMed]
• Olthof Pim B., Coelen Robert J., Heger Michal, Klümpen Heinz-Josef, Rauws Erik A., van Gulik Thomas M. Emerging local ablative therapies for unresectable perihilar cholangiocarinoma: Time for re-appraisal United European gastroenterology journal 2017;5 (3):455-457 [PubMed]
• Molenaar Remco J., Coelen Robert J. S., Khurshed Mohammed, Roos Eva, Caan Matthan W. A., van Linde Myra E., Kouwenhoven Mathilde, Bramer Jos A. M., Bovée Judith V. M. G., Mathôt Ron A., Klümpen Heinz-Josef, van Laarhoven Hanneke W. M., van Noorden Cornelis J. F., Vandertop W. Peter, Gelderblom Hans, van Gulik Thomas M., Wilmink Johanna W. Study protocol of a phase IB/II clinical trial of metformin and chloroquine in patients with IDH1-mutated or IDH2-mutated solid tumours BMJ open 2017;7 (6):e014961 [PubMed]
• Coelen Robert J. S., Gaspersz Marcia P., Labeur Tim A., van Vugt Jeroen L. A., van Dieren Susan, Willemssen François E. J. A., Nio Chung Y., Ijzermans Jan N. M., Klümpen Heinz-Josef, Groot Koerkamp Bas, van Gulik Thomas M. Validation of the Mayo Clinic Staging System in Determining Prognoses of Patients With Perihilar Cholangiocarcinoma Clinical gastroenterology and hepatology 2017;15 (12):1930-+ [PubMed]

2016

• Achterbergh Roos, Lammers Laureen A., van Nierop Samuel, Klümpen Heinz-Josef, Soeters Maarten R., Mathôt Ron A. A., Romijn Johannes A. A short-term high fat diet increases exposure to midazolam and omeprazole in healthy subjects Expert opinion on drug metabolism & toxicology 2016;12 (7):715-720 [PubMed]
• de Vries E. M., Lammers L. A., Achterbergh R., Klümpen H.-J., Mathot R. A. A., Boelen A., Romijn J. A. Fasting-Induced Changes in Hepatic P450 Mediated Drug Metabolism Are Largely Independent of the Constitutive Androstane Receptor CAR PLoS ONE 2016;11 (7):e0159552 [PubMed]
• van Meer Suzanne, van Erpecum Karel J., Sprengers Dave, Coenraad Minneke J., Klümpen Heinz-Josef, Jansen Peter L. M., Ijzermans Jan N. M., Verheij Joanne, van Nieuwkerk Carin M. J., Siersema Peter D., de Man Robert A. Hepatocellular carcinoma in cirrhotic versus noncirrhotic livers: results from a large cohort in the Netherlands European journal of gastroenterology & hepatology 2016;28 (3):352-359 [PubMed]
• van Meer Suzanne, van Erpecum Karel J., Sprengers Dave, Klümpen Heinz-Josef, Jansen Peter L. M., Ijzermans Jan N. M., Siersema Peter D., de Man Robert A., Verheij Joanne Hepatocellular carcinoma in noncirrhotic livers is associated with steatosis rather than steatohepatitis: potential implications for pathogenesis European journal of gastroenterology & hepatology 2016;28 (8):955-962 [PubMed]
• Slagter A. E., Ryder D., Chakrabarty B., LaMarca A., Hubner R. A., Mansoor W., O'Reilly D. A., Fulford P. E., Klümpen H. J., Valle J. W., McNamara M. G. Prognostic factors for disease relapse in patients with neuroendocrine tumours who underwent curative surgery Surgical oncology 2016;25 (3):223-228 [PubMed]
• Lammers Laureen A., Achterbergh Roos, Pistorius Marcel C. M., Bijleveld Yuma, de Vries Emmely M., Boelen Anita, Klümpen Heinz-Josef, Romijn Johannes A., Mathôt Ron A. A. Quantitative Method for Simultaneous Analysis of a 5-Probe Cocktail for Cytochrome P450 Enzymes Therapeutic drug monitoring 2016;38 (6):761-768 [PubMed]

2015

• Stein Alexander, Arnold Dirk, Bridgewater John, Goldstein David, Jensen Lars Henrik, Klümpen Heinz-Josef, Lohse Ansgar W., Nashan Björn, Primrose John, Schrum Silke, Shannon Jenny, Vettorazzi Eik, Wege Henning Adjuvant chemotherapy with gemcitabine and cisplatin compared to observation after curative intent resection of cholangiocarcinoma and muscle invasive gallbladder carcinoma (ACTICCA-1 trial) - a randomized, multidisciplinary, multinational phase III trial BMC cancer 2015;15 (1):564 [PubMed]
• Kordes S., Klümpen H. J., Weterman M. J., Schellens J. H. M., Richel D. J., Wilmink J. W. Phase II study of capecitabine and the oral mTOR inhibitor everolimus in patients with advanced pancreatic cancer Cancer chemotherapy and pharmacology 2015;75 (6):1135-1141 [PubMed]
• Ricke Jens, Bulla Karsten, Kolligs Frank, Peck-Radosavljevic Markus, Reimer Peter, Sangro Bruno, Schott Eckart, Schütte Kerstin, Verslype Chris, Walecki Jerzy, Malfertheiner Peter, Cwikla J., Gebauer B., Klümpen H., Van Delden O., Rosmorduc O., Menu Y., Leroy V., Sengel C., Trumm C., Berg T., Moche M., Bilbao I., Gossner L., Popovic P., Stabuc B., Piasecki P., Podgajny Z., Sacco R., Bargellini I., Lammer J., Maleux G., Mayerle J., Rosenberg C., Nitsche D., Waldenberger P., Vergniol J., Cassinotto C., Yalcin S., Peynircioglu B., Zavaglia C., Rampoldi A., Tran A., Chevallier P., Anty R., Trautwein C., Kuhl C., Grazioli L., Vogl T., Trojan J. Safety and toxicity of radioembolization plus Sorafenib in advanced hepatocellular carcinoma: Analysis of the European multicentre trial SORAMIC Liver international 2015;35 (2):620-626 [PubMed]
• Lammers Laureen A., Achterbergh Roos, de Vries Emmely M., van Nierop F. Samuel, Klümpen Heinz-Josef, Soeters Maarten R., Boelen Anita, Romijn Johannes A., Mathôt Ron A. A. Short-term fasting alters cytochrome P450-mediated drug metabolism in humans Drug metabolism and disposition: the biological fate of chemicals 2015;43 (6):819-828 [PubMed]
• van Meer Suzanne, de Man Robert A., Coenraad Minneke J., Sprengers Dave, van Nieuwkerk Karin M. J., Klümpen Heinz-Josef, Jansen Peter L. M., Ijzermans Jan N. M., van Oijen Martijn G. H., Siersema Peter D., van Erpecum Karel J. Surveillance for hepatocellular carcinoma is associated with increased survival: Results from a large cohort in the Netherlands Journal of hepatology 2015;63 (5):1156-1163 [PubMed]
• van der Geest Lydia G. M., van Meer Suzanne, Schrier Janina G. H., Ijzermans Jan N. M., Klümpen Heinz-Josef, van Erpecum Karel J., de Man Rob A. Survival in relation to hospital type after resection or sorafenib treatment for hepatocellular carcinoma in The Netherlands Clinics and research in hepatology and gastroenterology 2015;39 (6):725-735 [PubMed]
• Coelen Robert J. S., Huiskens Joost, van Delden Otto M., Klümpen Heinz-Josef, Rauws Erik A. J., van Gulik Thomas M. Verwijzing bij verdenking perihilair cholangiocarcinoom kan beter Magma: Tijdschrift van de Nederlandse Vereniging van Maag-darm-leverartsen 2015;21 (4):153-154

2014

• Diekstra M. H. M., Klümpen H. J., Lolkema M. P. J. K., Yu H., Kloth J. S. L., Gelderblom H., van Schaik R. H. N., Gurney H., Swen J. J., Huitema A. D. R., Steeghs N., Mathijssen R. H. J. Association analysis of genetic polymorphisms in genes related to sunitinib pharmacokinetics, specifically clearance of sunitinib and SU12662 Clinical pharmacology and therapeutics 2014;96 (1):81-89 [PubMed]
• Bieze Matthanja, Klümpen Heinz-Josef, Verheij Joanne, Beuers Ulrich, Phoa Saffire S. K. S., van Gulik Thomas M., Bennink Roelof J. Diagnostic Accuracy of (18) F-Methylcholine Positron Emission Tomography/Computed Tomography for Intra- and Extrahepatic Hepatocellular Carcinoma Hepatology (Baltimore, Md.) 2014;59 (3):996-1006 [PubMed]
• Eskens F. A. L. M., van Erpecum K. J., de Jong K. P., van Delden O. M., Klumpen H. J., Verhoef C., Jansen P. L. M., van den Bosch M. A. A. J., Méndez Romero A., Verheij J., Bloemena E., de Man R. A. Hepatocellular carcinoma: Dutch guideline for surveillance, diagnosis and therapy Netherlands journal of medicine 2014;72 (6):299-304 [PubMed]
• Bennink Roelof J., Cieslak Kasia P., van Delden Otto M., van Lienden Krijn P., Klümpen Heinz-Josef, Jansen Peter L., van Gulik Thomas M. Monitoring of Total and Regional Liver Function after SIRT Frontiers in oncology 2014;4:152 [PubMed]
• Kloth Jacqueline S. L., Klümpen Heinz-Josef, Yu Huixin, Eechoute Karel, Samer Caroline F., Kam Boen L. R., Huitema Alwin D. R., Daali Youssef, Zwinderman Aeilko H., Balakrishnar Bavanthi, Bennink Roelof J., Wong Mark, Schellens Jan H. M., Mathijssen Ron H. J., Gurney Howard Predictive value of CYP3A and ABCB1 phenotyping probes for the pharmacokinetics of sunitinib: the ClearSun study Clinical pharmacokinetics 2014;53 (3):261-269 [PubMed]
• Ruys Anthony T., Groot Koerkamp Bas, Wiggers Jimme K., Klümpen Heinz-Josef, ten Kate Fiebo J., van Gulik Thomas M. Prognostic biomarkers in patients with resected cholangiocarcinoma: a systematic review and meta-analysis Annals of surgical oncology 2014;21 (2):487-500 [PubMed]

2013

• Kordes Sil, Richel Dick J., Klümpen Heinz-Josef, Weterman Mariëtte J., Stevens Arnoldus J. W. M., Wilmink Johanna W. A phase I/II, non-randomized, feasibility/safety and efficacy study of the combination of everolimus, cetuximab and capecitabine in patients with advanced pancreatic cancer Investigational new drugs 2013;31 (1):85-91 [PubMed]
• Korsse S. E., Eskens F. A. L. M., Bastiaansen B. A. J., Kuipers E. J., Mathus-Vliegen E. M. H., Dekker E., Dewint P., Klümpen H. J. EVAMP: pilotstudie van everolimus voor de behandeling van hamartomen en carcinomen bij patiënten met het syndroom van Peutz-Jeghers. Nederlands tijdschrift voor oncologie 2013;10:165-167
• Klümpen H. J. Geïndividualiseerde geneeskunde van gerichte kankerbehandeling Nederlands tijdschrift voor oncologie 2013;10:42-44
• Malek Nisar Peter, Neumann Ulf Peter, Ricke Jens, Berg Thomas, Bruns Christiane, Denecke Timm, Klumpen Heinz-Josef, Lippert Hans, Pech Maciej, Peck-Radosavljevic Markus Hepatocellular Carcinoma - an Interdisciplinary Disease Pattern Viszeralmedizin 2013;29 (2):113-119
• Finn Richard S., Poon Ronnie T. P., Yau Thomas, Klümpen Heinz-Josef, Chen Li-Tzong, Kang Yoon-Koo, Kim Tae-You, Gomez-Martin Carlos, Rodriguez-Lope Carlos, Kunz Tiffany, Paquet Thierry, Brandt Ulrike, Sellami Dalila, Bruix Jordi Phase I study investigating everolimus combined with sorafenib in patients with advanced hepatocellular carcinoma Journal of hepatology 2013;59 (6):1271-1277 [PubMed]
• Jilesen Anneke P. J., Klumpen Heinz-Josef, Busch Olivier R. C., van Gulik Thomas M., van Lienden Krijn P., Gouma Dirk J., Nieveen van Dijkum Els J. M. Selective arterial embolization of liver metastases from gastrinomas: a single-centre experience ISRN Hepatology 2013;2013:1-8

2012

• Deenen Maarten J., Klümpen Heinz-Josef, Richel Dick J., Sparidans Rolf W., Weterman Mariette J., Beijnen Jos H., Schellens Jan H. M., Wilmink Johanna W. Phase I and pharmacokinetic study of capecitabine and the oral mTOR inhibitor everolimus in patients with advanced solid malignancies Investigational new drugs 2012;30 (4):1557-1565 [PubMed]

2011

• Klümpen Heinz-Josef, Samer Caroline F., Mathijssen Ron H. J., Schellens Jan H. M., Gurney Howard Moving towards dose individualization of tyrosine kinase inhibitors Cancer treatment reviews 2011;37 (4):251-260 [PubMed]
• Klümpen Heinz-Josef, Queiroz Karla C. S., Spek C. Arnold, van Noesel Carel J. M., Brink Helmy C., de Leng Wendy W. J., de Wilde Roeland F., Mathus-Vliegen Elisabeth M. H., Offerhaus G. Johan A., Alleman Maarten A., Westermann Anneke M., Richel Dirk J. mTOR inhibitor treatment of pancreatic cancer in a patient With Peutz-Jeghers syndrome Journal of clinical oncology 2011;29 (6):e150-e153 [PubMed]

2010

• Klümpen Heinz-Josef, Beijnen Jos H., Gurney Howard, Schellens Jan H. M. Inhibitors of mTOR oncologist 2010;15 (12):1262-1269 [PubMed]
• van Kuilenburg André B. P., Meijer Judith, Mul Adri N. P. M., Meinsma Rutger, Schmid Veronika, Dobritzsch Doreen, Hennekam Raoul C. M., Mannens Marcel M. A. M., Kiechle Marion, Etienne-Grimaldi Marie-Christine, Klümpen Heinz-Josef, Maring Jan Gerard, Derleyn Veerle A., Maartense Ed, Milano Gérard, Vijzelaar Raymon, Gross Eva Intragenic deletions and a deep intronic mutation affecting pre-mRNA splicing in the dihydropyrimidine dehydrogenase gene as novel mechanisms causing 5-fluorouracil toxicity Human genetics 2010;128 (5):529-538 [PubMed]

2008

• van Kuilenburg André B. P., Klumpen Heinz-Josef, Westermann Anneke M., Zoetekouw Lida, Bakker Piet J. M., Guchelaar Henk-Jan, Richel Dick J. Altered dihydropyrimidine dehydrogenase activity associated with mild toxicity in patients treated with 5-fluorouracil containing chemotherapy Nucleosides, nucleotides & nucleic acids 2008;27 (6):726-732 [PubMed]
• Gao Bo, Klumpen Heinz-Josef, Gurney Howard Dose calculation of anticancer drugs Expert opinion on drug metabolism & toxicology 2008;4 (10):1307-1319 [PubMed]
• Klumpen Heinz-Joseph, Liddle Chris, Gurney Howard Transporter pumps and imatinib: a cause of pharmacokinetic resistance? Cancer biology & therapy 2008;7 (3):416-418 [PubMed]

2007

• van Kuilenburg André B. P., Klumpen Heinz-Josef, Westermann Anneke M., Zoetekouw Lida, van Lenthe Henk, Bakker Piet J. M., Richel Dick J., Guchelaar Henk-Jan Increased dihydropyrimidine dehydrogenase activity associated with mild toxicity in patients treated with 5-fluorouracil and leucovorin European journal of cancer (Oxford, England 2007;43 (2):459-465 [PubMed]

2004

• Klümpen H. J., Petersen E. J., Verdonck L. F. Severe multiorgan failure after parvovirus B19 infection in an allogeneic stem cell transplant recipient Bone marrow transplantation 2004;34 (5):469-470 [PubMed]

2000

• de Gast G. C., Klümpen H. J., Vyth-Dreese F. A., Kersten M. J., Verra N. C., Sein J., Batchelor D., Nooijen W. J., Schornagel J. H. Phase I trial of combined immunotherapy with subcutaneous granulocyte macrophage colony-stimulating factor, low-dose interleukin 2, and interferon alpha in progressive metastatic melanoma and renal cell carcinoma Clinical cancer research 2000;6 (4):1267-1272 [PubMed]