J. den Dunnen PhD publications

2020

• Hoepel Willianne, Golebski Korneliusz, van Drunen Cornelis M., den Dunnen Jeroen Active control of mucosal tolerance and inflammation by human IgA and IgG antibodies Journal of allergy and clinical immunology 2020;146 (2):273-275 [PubMed]
• Larsen Mads Delbo, de Graaf Erik L, Sonneveld Myrthe E, Plomp H Rosina, Nouta Jan, Hoepel Willianne, Chen Hung-Jen, Linty Federica, Visser Remco, Brinkhaus Maximilian, Šuštić Tonći, de Taeye Steven W, Bentlage Arthur E H, Toivonen Suvi, Koeleman Carolien A M, Sainio Susanna, Kootstra Neeltje A, Brouwer Philip J M, Geyer Chiara Elisabeth, Derksen Ninotska I L, Wolbink Gertjan, de Winther Menno, Sanders Rogier W, van Gils Marit J, de Bruin Sanne, Vlaar Alexander P J, Rispens Theo, den Dunnen Jeroen, Zaaijer Hans L, Wuhrer Manfred, Ellen van der Schoot C, Vidarsson Gestur Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity Science 2020 [PubMed]
• Newling M., Fiechter R. H., Sritharan L., Hoepel W., van Burgsteden J. A., Hak A. E., van Vollenhoven R. F., van de Sande M. G. H., Baeten D. L. P., den Dunnen J. Dysregulated Fcγ receptor IIa-induced cytokine production in dendritic cells of lupus nephritis patients Clinical and experimental immunology 2020;199 (1):39-49 [PubMed]
• van der Poel Marlijn, Hoepel Willianne, Hamann J. rg, Huitinga Inge, Dunnen Jeroen den IgG Immune Complexes Break Immune Tolerance of Human Microglia Journal of immunology (Baltimore, Md. 2020;205 (9):2511-2518 [PubMed]
• Hoepel Willianne, Allahverdiyeva Sona, Harbiye Haneen, de Taeye Steven W., van der Ham Alwin J., de Boer Leonie, Zaat Sebastiaan A. J., van Weeghel Michel, Baeten Dominique L. P., Houtkooper Riekelt H., Everts Bart, Vidarsson Gestur, den Dunnen Jeroen IgG Subclasses Shape Cytokine Responses by Human Myeloid Immune Cells through Differential Metabolic Reprogramming Journal of immunology (Baltimore, Md. 2020;205 (12):3400-3407 [PubMed]
• Newling Melissa The role of FcγRs in inflammation during infection and autoimmunity 2020. 181p. ISBN 9789463758895. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Baeten Dominique L. P.; Co-supervisor: den Dunnen Jeroen)

2019

• Newling Melissa, Sritharan Lathees, van der Ham Alwin J., Hoepel Willianne, Fiechter Renee H., de Boer Leonie, Zaat Sebastian A. J., Bisoendial Radjesh J., Baeten Dominique L. P., Everts Bart, den Dunnen Jeroen C-Reactive protein promotes inflammation through FcγR-Induced glycolytic reprogramming of human macrophages Journal of immunology (Baltimore, Md. 2019;203 (1):225-235 [PubMed]
• Hansen Ivo S., Schoonejans Josca M., Sritharan Lathees, van Burgsteden Johan A., Ambarus Carmen A., Baeten Dominique L. P., den Dunnen Jeroen ER stress abrogates the immunosuppressive effect of IL-10 on human macrophages through inhibition of STAT3 activation Inflammation research 2019;68 (9):775-785 [PubMed]
• Golebski K., Hoepel W., van Egmond D., de Groot E. J., Amatngalim G. D., Beekman J. M., Fokkens W. J., van Drunen C. M., den Dunnen J. FcγRIII stimulation breaks the tolerance of human nasal epithelial cells to bacteria through cross-talk with TLR4 Mucosal immunology 2019;12 (2):425-433 [PubMed]
• Hoepel Willianne, Newling Melissa, Vogelpoel Lisa T. C., Sritharan Lathees, Hansen Ivo S., Kapsenberg Martien L., Baeten Dominique L. P., Everts Bart, den Dunnen Jeroen FcγR-TLR Cross-Talk Enhances TNF Production by Human Monocyte-Derived DCs via IRF5-Dependent Gene Transcription and Glycolytic Reprogramming Frontiers in immunology 2019;10:739 [PubMed]
• Hansen Ivo S., Baeten Dominique L. P., den Dunnen Jeroen The inflammatory function of human IgA Cellular and molecular life sciences 2019;76 (6):1041-1055 [PubMed]

2018

• Newling Melissa, Hoepel Willianne, Vogelpoel Lisa T. C., Heineke Marieke H., van Burgsteden Johan A., Taanman-Kueter Esther W. M., Eggink Dirk, Kuijpers Taco W., Beaumont Tim, van Egmond Marjolein, Kapsenberg Martien L., Baeten Dominique L. P., den Dunnen Jeroen, Jong Esther C. de Fc gamma receptor IIa suppresses type I and III interferon production by human myeloid immune cells European journal of immunology 2018;48 (11):1796-1809 [PubMed]
• Hansen Ivo S., Krabbendam Lisette, Bernink Jochem H., Loayza-Puch Fabricio, Hoepel Willianne, van Burgsteden Johan A., Kuijper Elsa C., Buskens Christianne J., Bemelman Willem A., Zaat Sebastiaan A. J., Agami Reuven, Vidarsson Gestur, van den Brink Gijs R., de Jong Esther C., Wildenberg Manon E., Baeten Dominique L. P., Everts Bart, den Dunnen Jeroen FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming Nature communications 2018;9 (1):863 [PubMed]

2017

• Hansen Ivo S., Hoepel Willianne, Zaat Sebastiaan A. J., Baeten Dominique L. P., den Dunnen Jeroen Serum IgA Immune Complexes Promote Proinflammatory Cytokine Production by Human Macrophages, Monocytes, and Kupffer Cells through FcαRI-TLR Cross-Talk Journal of immunology (Baltimore, Md. 2017;199 (12):4124-4131 [PubMed]

2015

• Vogelpoel Lisa T. C., Baeten Dominique L. P., de Jong Esther C., den Dunnen Jeroen Control of cytokine production by human Fc gamma receptors: implications for pathogen defense and autoimmunity Frontiers in immunology 2015;6:79 [PubMed]
• Vogelpoel Lisa Theodora Catharina FcγRIIa, a novel director of cytokine production in infection and autoimmunity 2015. 176p. ISBN 9789462330771. [UvA Dissertations Online] University of Amsterdam. (Supervisors: de Jong E. C., Kapsenberg M. L.; Co-supervisor: den Dunnen J.)
• Vogelpoel Lisa T. C., Hansen Ivo S., Visser Marijke W., Nagelkerke Sietse Q., Kuijpers Taco W., Kapsenberg Martien L., de Jong Esther C., den Dunnen Jeroen FcγRIIa cross-talk with TLRs, IL-1R, and IFNγR selectively modulates cytokine production in human myeloid cells Immunobiology 2015;220 (2):193-199 [PubMed]

2014

• Vogelpoel Lisa T. C., Hansen Ivo S., Rispens Theo, Muller Femke J. M., van Capel Toni M. M., Turina Maureen C., Vos Joost B., Baeten Dominique L. P., Kapsenberg Martien L., de Jong Esther C., den Dunnen Jeroen Fc gamma receptor-TLR cross-talk elicits pro-inflammatory cytokine production by human M2 macrophages Nature communications 2014;5:5444 [PubMed]

2012

• den Dunnen Jeroen, Vogelpoel Lisa T. C., Wypych Tomasz, Muller Femke J. M., de Boer Leonie, Kuijpers Taco W., Zaat Sebastiaan A. J., Kapsenberg Martien L., de Jong Esther C. IgG opsonization of bacteria promotes Th17 responses via synergy between TLRs and Fc gamma RIIa in human dendritic cells Blood 2012;120 (1):112-121 [PubMed]

2010

• den Dunnen Jeroen, Gringhuis Sonja I., Geijtenbeek Teunis B. H. Dusting the sugar fingerprint: C-type lectin signaling in adaptive immunity Immunology letters 2010;128 (1):12-16 [PubMed]
• Gringhuis Sonja I., van der Vlist Michiel, van den Berg Linda M., den Dunnen Jeroen, Litjens Manja, Geijtenbeek Teunis B. H. HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells Nature immunology 2010;11 (5):419-U81 [PubMed]

2009

• Gringhuis Sonja I., den Dunnen Jeroen, Litjens Manja, van der Vlist Michiel, Geijtenbeek Teunis B. H. Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori Nature immunology 2009;10 (10):1081-U58 [PubMed]
• den Dunnen Jeroen C-type lectin signaling in response to pathogens 2009. 194p. ISBN 9789085702863. [UvA Dissertations Online] Vrije Universiteit Amsterdam: MCBI. (Supervisor: van Kooyk Y.; Co-supervisors: Geijtenbeek T. B. H., Gringhuis S. I.)
• Gringhuis Sonja I., den Dunnen Jeroen, Litjens Manja, van der Vlist Michiel, Wevers Brigitte, Bruijns Sven C. M., Geijtenbeek Teunis B. H. Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk Nature immunology 2009;10 (2):203-213 [PubMed]
• de Witte Lot, de Jong Marein A. W. P., den Dunnen Jeroen, van Kooyk Yvette, Geijtenbeek Teunis B. H. Identification of pathogen receptors on dendritic cells to understand their function and to identify new drug targets Methods in molecular biology (Clifton, N.J.) 2009;531:267-285 [PubMed]
• den Dunnen Jeroen, Gringhuis Sonja I., Geijtenbeek Teunis B. H. Innate signaling by the C-type lectin DC-SIGN dictates immune responses Cancer immunology, immunotherapy 2009;58 (7):1149-1157 [PubMed]
• Geijtenbeek Teunis B. H., den Dunnen Jeroen, Gringhuis Sonja I. Pathogen recognition by DC-SIGN shapes adaptive immunity Future microbiology 2009;4 (7):879-890 [PubMed]

2008

• Hovius Joppe W. R., de Jong Marein A. W. P., den Dunnen Jeroen, Litjens Manja, Fikrig Erol, van der Poll Tom, Gringhuis Sonja I., Geijtenbeek Teunis B. H. Salp15 binding to DC-SIGN inhibits cytokine expression by impairing both nucleosome remodeling and mRNA stabilization PLoS pathogens 2008;4 (2):e31 [PubMed]
• Appelmelk B. J., den Dunnen J., Driessen N. N., Ummels R., Pak M., Nigou J., Larrouy-Maumus G., Gurcha S. S., Movahedzadeh F., Geurtsen J., Brown E. J., Eysink Smeets M. M., Besra G. S., Willemsen P. T. J., Lowary T. L., van Kooyk Y., Maaskant J. J., Stoker N. G., van der Ley P., Puzo G., Vandenbroucke-Grauls C. M. J. E., Wieland C. W., van der Poll T., Geijtenbeek T. B. H., van der Sar A. M., Bitter W. The mannose cap of mycobacterial lipoarabinomannan does not dominate the Mycobacterium-host interaction Cellular microbiology 2008;10 (4):930-944 [PubMed]

2007

• Gringhuis Sonja I., den Dunnen Jeroen, Litjens Manja, van het Hof Bert, van Kooyk Yvette, Geijtenbeek Teunis B. H. C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB Immunity 2007;26 (5):605-616 [PubMed]
• van Vliet Sandra J., den Dunnen Jeroen, Gringhuis Sonja I., Geijtenbeek Teunis Bh, van Kooyk Yvette Innate signaling and regulation of Dendritic cell immunity Current opinion in immunology 2007;19 (4):435-440 [PubMed]
• Wieland Catharina W., Koppel Estella A., den Dunnen Jeroen, Florquin Sandrine, McKenzie Andrew N. J., van Kooyk Yvette, van der Poll Tom, Geijtenbeek Teunis B. H. Mice lacking SIGNR1 have stronger T helper 1 responses to Mycobacterium tuberculosis Microbes and infection / Institut Pasteur 2007;9 (2):134-141 [PubMed]