J. Kroon PhD publications

2021

• Waissi Farahnaz, de Kleijn Dominique P. V., Kroon Jeffrey Response by Waissi et al Regarding Article, "Elevated Lp(a) (Lipoprotein[a]) Levels Increase Risk of 30-Day Major Adverse Cardiovascular Events in Patients Following Carotid Endarterectomy" Stroke; a journal of cerebral circulation 2021;52 (2):e66-e67 [PubMed]

2020

• Schnitzler Johan G., Hoogeveen Renate M., Ali Lubna, Prange Koen H. M., Waissi Farahnaz, van Weeghel Michel, Bachmann Julian C., Versloot Miranda, Borrelli Matthew J., Yeang Calvin, de Kleijn Dominique P. V., Houtkooper Riekelt H., Koschinsky Marlys L., de Winther Menno P. J., Groen Albert K., Witztum Joseph L., Tsimikas Sotirios, Stroes Erik S. G., Kroon Jeffrey Atherogenic Lipoprotein(a) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation Circulation research 2020;126 (10):1346-1359 [PubMed]
• Wasiak Sylwia, Dzobo Kim E., Rakai Brooke D., Kaiser Yannick, Versloot Miranda, Bahjat Mahnoush, Stotz Stephanie C., Fu Li, Sweeney Michael, Johansson Jan O., Wong Norman C. W., Stroes Erik S. G., Kroon Jeffrey, Kulikowski Ewelina BET protein inhibitor apabetalone (RVX-208) suppresses pro-inflammatory hyper-activation of monocytes from patients with cardiovascular disease and type 2 diabetes Clinical epigenetics 2020;12 (1) [PubMed]
• Waissi Farahnaz, Dekker Mirthe, Timmerman Nathalie, Hoogeveen Renate M., van Bennekom Joelle, Dzobo Kim E., Schnitzler Johan G., Pasterkamp Gerard, Grobbee Diederick E., de Borst Gert J., Stroes Erik S. G., de Kleijn Dominique P. V., Kroon Jeffrey Elevated Lp(a) (Lipoprotein[a]) Levels Increase Risk of 30-Day Major Adverse Cardiovascular Events in Patients Following Carotid Endarterectomy Stroke; a journal of cerebral circulation 2020;51 (10):2972-2982 [PubMed]
• Bruikman Caroline S., Dalila Nawar, van Capelleveen Julian C., Kroon Jeffrey, Peter Jorge, Havik Stefan R., Willems Martine, Huisman Laurens C., de Boer Onno J., Hovingh G. Kees, Tybjaerg-Hansen Anne, Dallinga-Thie Geesje M. Genetic variants in SUSD2 are associated with the risk of ischemic heart disease Journal of clinical lipidology 2020;14 (4):470-481 [PubMed]
• Poels Kikkie, Schnitzler Johan G., Waissi Farahnaz, Levels Johannes H. M., Stroes Erik S. G., Daemen Mat J. A. P., Lutgens Esther, Pennekamp Anne-Marije, de Kleijn Dominique P. V., Seijkens Tom T. P., Kroon Jeffrey Inhibition of PFKFB3 Hampers the Progression of Atherosclerosis and Promotes Plaque Stability Frontiers in cell and developmental biology 2020;8 [PubMed]
• de Groot Pieter F., Nikolic Tatjana, Imangaliyev Sultan, Bekkering Siroon, Duinkerken Gaby, Keij Fleur M., Herrema Hilde, Winkelmeijer Maaike, Kroon Jeffrey, Levin Evgeni, Hutten Barbara, Kemper Elles M., Simsek Suat, Levels Johannes H. M., van Hoorn Flora A., Bindraban Renuka, Berkvens Alicia, Dallinga-Thie Geesje M., Davids Mark, Holleman Frits, Hoekstra Joost B. L., Stroes Erik S. G., Netea Mihai, van Raalte Daniël H., Roep Bart O., Nieuwdorp Max Oral butyrate does not affect innate immunity and islet autoimmunity in individuals with longstanding type 1 diabetes: a randomised controlled trial Diabetologia 2020;63 (3):597-610 [PubMed]
• Stiekema Lotte C. A., Prange Koen H. M., Hoogeveen Renate M., Verweij Simone L., Kroon Jeffrey, Schnitzler Johan G., Dzobo Kim E., Cupido Arjen J., Tsimikas Sotirios, Stroes Erik S. G., de Winther Menno P. J., Bahjat Mahnoush Potent lipoprotein(a) lowering following apolipoprotein(a) antisense treatment reduces the pro-inflammatory activation of circulating monocytes in patients with elevated lipoprotein(a) European heart journal 2020;41 (24):2262-2271 [PubMed]
• Schnitzler Johan G., Poels Kikkie, Stiekema Lotte C. A., Yeang Calvin, Tsimikas Sotirios, Kroon Jeffrey, Stroes Erik S. G., Lutgens Esther, Seijkens Tom T. P. Short-term regulation of hematopoiesis by lipoprotein(a) results in the production of pro-inflammatory monocytes International journal of cardiology 2020;315:81-85 [PubMed]
• Schnitzler Johan G., Dzobo Kim E., Nurmohamed Nick S., Stroes Erik S. G., Kroon Jeffrey Surmounting the endothelial barrier for delivery of drugs and imaging tracers Atherosclerosis 2020;315:93-101 [PubMed]
• Ståhle Mia, Silvola Johanna M. U., Hellberg Sanna, de Vries Margreet, Quax Paul H. A., Kroon Jeffrey, Rinne Petteri, de Jong Alwin, Liljenbäck Heidi, Savisto Nina, Wickman Anna, Stroes Erik S. G., Ylä-Herttuala Seppo, Saukko Pekka, Abrahamsson Tommy, Pettersson Knut, Knuuti Juhani, Roivainen Anne, Saraste Antti Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular 18F-FDG Uptake in Atherosclerotic Mice JACC. Basic to translational science 2020;5 (4):360-373 [PubMed]

2019

• Zheng Kang H., Tsimikas Sotirios, Pawade Tania, Kroon Jeffrey, Jenkins William S. A., Doris Mhairi K., White Audrey C., Timmers Nyanza K. L. M., Hjortnaes Jesper, Rogers Maximillian A., Aikawa Elena, Arsenault Benoit J., Witztum Joseph L., Newby David E., Koschinsky Marlys L., Fayad Zahi A., Stroes Erik S. G., Boekholdt S. Matthijs, Dweck Marc R. Lipoprotein(a) and Oxidized Phospholipids Promote Valve Calcification in Patients With Aortic Stenosis Journal of the American College of Cardiology 2019;73 (17):2150-2162 [PubMed]
• Schnitzler Johan G., Ali Lubna, Groenen Anouk G., Kaiser Yannick, Kroon Jeffrey Lipoprotein(A) as orchestrator of calcific aortic valve stenosis Biomolecules 2019;9 (12) [PubMed]
• van den Boogert Marjolein A. W., Larsen Lars E., Ali Lubna, Kuil Sacha D., Chong Patrick L. W., Loregger Anke, Kroon Jeffrey, Schnitzler Johan G., Schimmel Alinda W. M., Peter Jorge, Levels Johannes H. M., Steenbergen Gerry, Morava Eva, Dallinga-Thie Geesje M., Wevers Ron A., Kuivenhoven Jan Albert, Hand Nicholas J., Zelcer Noam, Rader Daniel J., Stroes Erik S. G., Lefeber Dirk J., Holleboom Adriaan G. N-Glycosylation Defects in Humans Lower Low-Density Lipoprotein Cholesterol Through Increased Low-Density Lipoprotein Receptor Expression Circulation 2019;140 (4):280-292 [PubMed]
• Bakker Guido J., Schnitzler Johan G., Bekkering Siroon, de Clercq Nicolien C., Koopen Annefleur M., Hartstra Annick V., Meessen Emma C. E., Scheithauer Torsten P., Winkelmeijer Maaike, Dallinga-Thie Geesje M., Cani Patrice D., Kemper Elles Marleen, Soeters Maarten R., Kroon Jeffrey, Groen Albert K., van Raalte Daniël H., Herrema Hilde, Nieuwdorp Max Oral vancomycin treatment does not alter markers of postprandial inflammation in lean and obese subjects Physiological reports 2019;7 (16) [PubMed]
• Hoogeveen Renate M., Opstal Tjerk S. J., Kaiser Yannick, Stiekema Lotte C. A., Kroon Jeffrey, Knol Remco J. J., Bax Willem A., Verberne Hein J., Cornel Jan H., Stroes Erik S. G. PCSK9 Antibody Alirocumab Attenuates Arterial Wall Inflammation Without Changes in Circulating Inflammatory Markers JACC. Cardiovascular imaging 2019;12 (12):2571-2573 [PubMed]
• Wenstedt Eliane F. E., Verberk Sanne G. S., Kroon Jeffrey, Neele Annette E., Baardman Jeroen, Claessen Nike, Pasaoglu Ozge T., Rademaker Emma, Schrooten Esmee M., Wouda Rosa D., de Winther Menno P. J., Aten Jan, Vogt Liffert, van den Bossche Jan Salt increases monocyte CCR2 expression and inflammatory responses in humans JCI insight 2019;4 (21) [PubMed]
• Schnitzler Johan G., Dallinga-Thie Geesje M., Kroon Jeffrey The role of (Modified) lipoproteins in vascular function: A duet between monocytes and the endothelium Current medicinal chemistry 2019;26 (9):1594-1609 [PubMed]

2018

• Lameijer Marnix, Binderup Tina, van Leent Mandy M. T., Senders Max L., Fay Francois, Malkus Joost, Sanchez-Gaytan Brenda L., Teunissen Abraham J. P., Karakatsanis Nicolas, Robson Philip, Zhou Xianxiao, Ye Yuxiang, Wojtkiewicz Gregory, Tang Jun, Seijkens Tom T. P., Kroon Jeffrey, Stroes Erik S. G., Kjaer Andreas, Ochando Jordi, Reiner Thomas, Pérez-Medina Carlos, Calcagno Claudia, Fischer Edward A., Zhang Bin, Temel Ryan E., Swirski Filip K., Nahrendorf Matthias, Fayad Zahi A., Lutgens Esther, Mulder Willem J. M., Duivenvoorden Raphaël Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates Nature Biomedical Engineering 2018;2 (5):279-292 [PubMed]
• Lameijer Marnix, Binderup Tina, van Leent Mandy M. T., Senders Max L., Fay Francois, Malkus Joost, Sanchez-Gaytan Brenda L., Teunissen Abraham J. P., Karakatsanis Nicolas, Robson Philip, Zhou Xianxiao, Ye Yuxiang, Wojtkiewicz Gregory, Tang Jun, Seijkens Tom T. P., Kroon Jeffrey, Stroes Erik S. G., Kjaer Andreas, Ochando Jordi, Reiner Thomas, Pérez-Medina Carlos, Calcagno Claudia, Fisher Edward A., Zhang Bin, Temel Ryan E., Swirski Filip K., Nahrendorf Matthias, Fayad Zahi A., Lutgens Esther, Mulder Willem J. M., Duivenvoorden Raphaël Erratum to: Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates (Nature Biomedical Engineering, (2018), 2, 5, (279-292), 10.1038/s41551-018-0221-2) Nature Biomedical Engineering 2018;2 (8):623 [PubMed]
• Kroon Jeffrey, Schaefer Antje, van Rijssel Jos, Hoogenboezem Mark, van Alphen Floris, Hordijk Peter, Stroes Erik S. G., Strömblad Staffan, van Rheenen Jacco, van Buul Jaap D. Inflammation-Sensitive Myosin-X Functionally Supports Leukocyte Extravasation by Cdc42-Mediated ICAM-1-Rich Endothelial Filopodia Formation Journal of immunology (Baltimore, Md. 2018;200 (5):1790-1801 [PubMed]
• Ali Lubna, Schnitzler Johan G., Kroon Jeffrey Metabolism: The road to inflammation and atherosclerosis Current opinion in lipidology 2018;29 (6):474-480 [PubMed]
• Neele Annette E., Gijbels Marion J. J., van der Velden Saskia, Hoeksema Marten A., Boshuizen Marieke C. S., Prange Koen H. M., Chen Hung-Jen, van den Bossche Jan, van Roomen Cindy P. P. A., Shami Annelie, Levels Johannes H. M., Kroon Jeffrey, Lucas Tina, Dimmeler Stefanie, Lutgens Esther, de Winther Menno P. J. Myeloid Kdm6b deficiency results in advanced atherosclerosis Atherosclerosis 2018;275:156-165 [PubMed]
• Verweij Simone L., Stiekema Lotte C. A., Delewi Ronak, Zheng Kang H., Bernelot Moens Sophie J., Kroon Jeffrey, Stroes Charlotte I., Versloot Miranda, Piek Jan J., Verberne Hein J., Stroes Erik S. G. Prolonged hematopoietic and myeloid cellular response in patients after an acute coronary syndrome measured with 18F-DPA-714 PET/CT European journal of nuclear medicine and molecular imaging 2018;45 (11):1956-1963 [PubMed]

2017

• Bernelot Moens Sophie J., Verweij Simone L., van der Valk Fleur M., van Capelleveen Julian C., Kroon Jeffrey, Versloot Miranda, Verberne Hein J., Marquering Henk A., Duivenvoorden Raphaël, Vogt Liffert, Stroes Erik S. G. Arterial and Cellular Inflammation in Patients with CKD Journal of the American Society of Nephrology 2017;28 (4):1278-1285 [PubMed]
• Kroon Jeffrey, Heemskerk Niels, Kalsbeek Martin J. T., de Waard Vivian, van Rijssel Jos, van Buul Jaap D. Flow-induced endothelial cell alignment requires the RhoGEF Trio as a scaffold protein to polarize active Rac1 distribution Molecular biology of the cell 2017;28 (13):1745-1753 [PubMed]
• Schnitzler Johan G., Bernelot Moens Sophie J., Tiessens Feiko, Bakker Guido J., Dallinga-Thie Geesje M., Groen Albert K., Nieuwdorp Max, Stroes Erik S. G., Kroon Jeffrey Nile Red Quantifier: a novel and quantitative tool to study lipid accumulation in patient- derived circulating monocytes using confocal microscopy Journal of lipid research 2017;58 (11):2210-2219 [PubMed]
• Bernelot Moens Sophie J., Neele Annette E., Kroon Jeffrey, van der Valk Fleur M., van den Bossche Jan, Hoeksema Marten A., Hoogeveen Renate M., Schnitzler Johan G., Baccara-Dinet Marie T., Manvelian Garen, de Winther Menno P. J., Stroes Erik S. G. PCSK9 monoclonal antibodies reverse the pro-inflammatory profile of monocytes in familial hypercholesterolaemia European heart journal 2017;38 (20):1584-1593 [PubMed]
• Bernelot Moens Sophie J., Verweij Simone L., Schnitzler Johan G., Stiekema Lotte C. A., Bos Merijn, Langsted Anne, Kuijk Carlijn, Bekkering Siroon, Voermans Carlijn, Verberne Hein J., Nordestgaard Børge G., Stroes Erik S. G., Kroon Jeffrey Remnant Cholesterol Elicits Arterial Wall Inflammation and a Multilevel Cellular Immune Response in Humans Arteriosclerosis, thrombosis, and vascular biology 2017;37 (5):969-975 [PubMed]

2016

• Lopes Pinheiro Melissa A., Kroon Jeffrey, Hoogenboezem Mark, Geerts Dirk, van het Hof Bert, van der Pol Susanne M. A., van Buul Jaap D., de Vries Helga E. Acid Sphingomyelinase-Derived Ceramide Regulates ICAM-1 Function during T Cell Transmigration across Brain Endothelial Cells Journal of immunology (Baltimore, Md. 2016;196 (1):72-79 [PubMed]
• Bernelot Moens Sophie J., van der Valk Fleur M., Strang Aart C., Kroon Jeffrey, Smits Loek P., Kneepkens Eva L., Verberne Hein J., van Buul Jaap D., Nurmohamed Michael T., Stroes Erik S. G. Erratum to: Unexpected arterial wall and cellular inflammation in patients with rheumatoid arthritis in remission using biological therapy: a cross-sectional study Arthritis research & therapy 2016;18 (1):298 [PubMed]
• Timmerman Ilse, Daniel Anna E., Kroon Jeffrey, van Buul Jaap D. Leukocytes Crossing the Endothelium: A Matter of Communication International review of cell and molecular biology 2016;322:281-329 [PubMed]
• van der Valk Fleur M., Bekkering Siroon, Kroon Jeffrey, Yeang Calvin, van den Bossche Jan, van Buul Jaap D., Ravandi Amir, Nederveen Aart J., Verberne Hein J., Scipione Corey, Nieuwdorp Max, Joosten Leo A. B., Netea Mihai G., Koschinsky Marlys L., Witztum Joseph L., Tsimikas Sotirios, Riksen Niels P., Stroes Erik S. G. Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans Circulation 2016;134 (8):611-624 [PubMed]
• Dallinga-Thie Geesje M., Kroon Jeffrey, Borén Jan, Chapman M. John Triglyceride-Rich Lipoproteins and Remnants: Targets for Therapy? Current cardiology reports 2016;18 (7):67 [PubMed]
• Bernelot Moens Sophie J., van der Valk Fleur M., Strang Aart C., Kroon Jeffrey, Smits Loek P., Kneepkens Eva L., Verberne Hein J., van Buul Jaap D., Nurmohamed Michael T., Stroes Erik S. G. Unexpected arterial wall and cellular inflammation in patients with rheumatoid arthritis in remission using biological therapy: a cross-sectional study Arthritis research & therapy 2016;18 (1):115 [PubMed]

2015

• Timmerman Ilse, Heemskerk Niels, Kroon Jeffrey, Schaefer Antje, van Rijssel Jos, Hoogenboezem Mark, van Unen Jakobus, Goedhart Joachim, Gadella Theodorus W. J., Yin Taofei, Wu Yi, Huveneers Stephan, van Buul Jaap D. A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1 Journal of cell science 2015;128 (16):3041-3054 [PubMed]
• Timmerman Ilse, Heemskerk Niels, Kroon Jeffrey, Schaefer Antje, van Rijssel Jos, Hoogenboezem Mark, van Unen Jakobus, Goedhart Joachim, Gadella Theodorus W. J., Yin Taofei, Wu Yi, Huveneers Stephan, van Buul Jaap D. A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1 (vol 128, pg 3041, 2015) Journal of cell science 2015;128 (18):3514 [PubMed]
• Kroon Jeffrey Signaling in vascular biology: The role of GTPases and GEFs in endothelial cell function 2015. 182p. ISBN 9789462951969. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Hordijk P. L.; Co-supervisor: van Buul J. D.)

2014

• Marinković Goran, Kroon Jeffrey, Hoogenboezem Mark, Hoeben Kees A., Ruiter Matthijs S., Kurakula Kondababu, Otermin Rubio Iker, Vos Mariska, de Vries Carlie J. M., van Buul Jaap D., de Waard Vivian Inhibition of GTPase Rac1 in endothelium by 6-mercaptopurine results in immunosuppression in nonimmune cells: new target for an old drug Journal of immunology (Baltimore, Md. 2014;192 (9):4370-4378 [PubMed]
• van der Valk Fleur M., Kroon Jeffrey, Potters Wouter V., Thurlings Rogier M., Bennink Roelof J., Verberne Hein J., Nederveen Aart J., Nieuwdorp Max, Mulder Willem J. M., Fayad Zahi A., van Buul Jaap D., Stroes Erik S. G. In vivo imaging of enhanced leukocyte accumulation in atherosclerotic lesions in humans Journal of the American College of Cardiology 2014;64 (10):1019-1029 [PubMed]
• Kooij Gijs, Kroon Jeffrey, Paul Debayon, Reijerkerk Arie, Geerts Dirk, van der Pol Susanne M. A., van het Hof Bert, Drexhage Joost A., van Vliet Sandra J., Hekking Liesbeth H. P., van Buul Jaap D., Pachter Joel S., de Vries Helga E. P-glycoprotein regulates trafficking of CD8(+) T cells to the brain parenchyma Acta neuropathologica 2014;127 (5):699-711 [PubMed]
• Kroon Jeffrey, Daniel Anna E., Hoogenboezem Mark, van Buul Jaap D. Real-time Imaging of Endothelial Cell-cell Junctions During Neutrophil Transmigration Under Physiological Flow Journal of visualized experiments 2014;2014 (90):e51766 [PubMed]

2013

• Post Ivo C. J. H., de Boon Wadim M. I., Heger Michal, van Wijk Albert C. W. A., Kroon Jeffrey, van Buul Jaap D., van Gulik Thomas M. Endothelial cell preservation at hypothermic to normothermic conditions using clinical and experimental organ preservation solutions Experimental cell research 2013;319 (17):2501-2513 [PubMed]
• Tugues Sònia, Honjo Satoshi, König Christian, Padhan Narendra, Kroon Jeffrey, Gualandi Laura, Li Xiujuan, Barkefors Irmeli, Thijssen Victor L., Griffioen Arjan W., Claesson-Welsh Lena Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-β1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in Vitro and in Vivo Journal of biological chemistry 2013;288 (26):19060-19071 [PubMed]
• Samson Thomas, van Buul Jaap D., Kroon Jeffrey, Welch Christopher, Bakker Erik N., Matlung Hanke L., van den Berg Timo K., Sharek Lisa, Doerschuk Claire, Hahn Klaus, Burridge Keith The guanine-nucleotide exchange factor SGEF plays a crucial role in the formation of atherosclerosis PLoS ONE 2013;8 (1):e55202 [PubMed]
• Kroon Jeffrey, Tol Simon, van Amstel Sven, Elias Judith A., Fernandez-Borja Mar The small GTPase RhoB regulates TNFα signaling in endothelial cells PLoS ONE 2013;8 (9):e75031 [PubMed]

2012

• van Rijssel Jos, Kroon Jeffrey, Hoogenboezem Mark, van Alphen Floris P. J., de Jong Renske J., Kostadinova Elena, Geerts Dirk, Hordijk Peter L., van Buul Jaap D. The Rho-guanine nucleotide exchange factor Trio controls leukocyte transendothelial migration by promoting docking structure formation Molecular biology of the cell 2012;23 (15):2831-2844 [PubMed]

2008

• van der Bij Gerben J., Bögels Marijn, Oosterling Steven J., Kroon Jeffrey, Schuckmann Dénise T. M., de Vries Helga E., Meijer Sybren, Beelen Robert H. J., van Egmond Marjolein Tumor infiltrating macrophages reduce development of peritoneal colorectal carcinoma metastases Cancer letters 2008;262 (1):77-86 [PubMed]