K.F.J. van de Graaf PhD publications

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Publications PhD K.F.J. van de Graaf

Position
Associate Professor
Main activities
Research, Other
Specialisation
Cholestatic liver diseases, metabolite signalling, Bile acid transport,
Focus of research

Metabolite dynamics and liver-centered organ crosstalk

A plethora of signals comes from the intestine in the form of metabolites produced by the microbiome with food as the source. Different types of food or food components are associated with improved health or with disease. Similarly, dysbiosis, or an aberrant intestinal microbiota composition and function, associates with many diseases. The ultimate goal of my research is to exploit the intestinal-derived signals to prevent or target common metabolic diseases, such as type 2 diabetes, NAFLD and atherosclerosis. Likely, the liver is the key to success as this organ is the first to detect and integrate the signals and plays a dominant role in controlling the spatial and temporal signaling of gut-derived metabolites.

Specifically, we aim to stimulate specific signals by modulating transport and detection pathways in the liver. To this end we generate novel tools to specifically modulate hepatic metabolite uptake/sensing in vivo. We use a variety of techniques, including (live cell) confocal microscopy, FRET imaging, biochemical characterization of transporter trafficking, cellular transport/enzymatic assays and high throughput screens with inhibitors/shRNA/gRNAs pools in combination with in vivo studies using transgenic mice, disease-mimicking cell systems and isolated organ perfusion.

Recent proof-of-concept data was obtained by targeting the bile acid transporter NTCP. Genetic and pharmacological targeting of this liver-specific transporter resulted in prolonged bile acid signaling leading to enhanced release of GLP1, increased energy expenditure, reduced intestinal lipid uptake and dampening of inflammation. Furthermore, shifting bile acids away from the liver into the peripheral circulation dampened hepatic damage due to cholestatic liver diseases (chole-stasis = impaired bile flow). NTCP inhibition dampens cholestatic liver injury by lowering hepatocellular bile salt accumulation and by reducing biliary toxicity. Cholestasis (impaired bile flow) constitutes a major cause of liver failure, since accumulated BSs are cytotoxic. This plays a role in multiple cholestatic liver diseases, including Primary Sclerosing Cholangitis, Primary Biliary Cholangitis and progressive intrahepatic familial cholestasis (PFIC). As a second and related research line we aim to open new areas of diagnosis, research and future treatment of cholestasis.

 

Amsterdam UMC Research Institutes
AMC departments
All publications

2021

  • Trampert David C, van de Graaf Stan F J, Jongejan Aldo, Oude Elferink Ronald P J, Beuers Ulrich Hepatobiliary acid-base homeostasis: Insights from analogous secretory epithelia Journal of hepatology 2021;74 (2):428-441 [PubMed]

2020

  • Balestra Dario, Scalet Daniela, Ferrarese Mattia, Lombardi Silvia, Ziliotto Nicole, Croes Chrystal C., Petersen Naomi, Bosma Piter, Riccardi Federico, Pagani Franco, Pinotti Mirko, van de Graaf Stan F. J. A compensatory U1snRNA partially rescues FAH splicing and protein expression in a splicing-defective mouse model of tyrosinemia type I International journal of molecular sciences 2020;21 (6) [PubMed]
  • Roscam Abbing Reinout L. P., Slijepcevic Davor, Donkers Joanne M., Havinga Rick, Duijst Suzanne, Paulusma Coen C., Kuiper Johan, Kuipers Folkert, Groen Albert K., Oude Elferink Ronald P. J., van de Graaf Stan F. J. Blocking Sodium-Taurocholate Cotransporting Polypeptide Stimulates Biliary Cholesterol and Phospholipid Secretion in Mice Hepatology (Baltimore, Md.) 2020;71 (1):247-258 [PubMed]
  • van de Wiel Sandra M. W. Intestinal transport and signaling of bile salts: A focus on OSTα-OSTβ 2020. 189p. ISBN 9789493184398. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van de Graaf Stan F. J., Oude Elferink Ronald P. J.)
  • Appelman Monique D. Molecular insight into the bile acid transporter NTCP 2020. 194p. ISBN 9789493197039. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van de Graaf Stan F. J., Oude Elferink Ronald P. J.)
  • Appelman Monique D., Robin Marion J. D., Vogels Esther W. M., Wolzak Christie, Vos Winnie G., Vos Harmjan R., van Es Robert M., Burgering Boudewijn M. T., van de Graaf Stan F. J. The Lipid Raft Component Stomatin Interacts with the Na+ Taurocholate Cotransporting Polypeptide (NTCP) and Modulates Bile Salt Uptake Cells 2020;9 (4) [PubMed]

2019

  • Donkers Joanne M., Roscam Abbing Reinout L.P., van de Graaf Konstantijn Developments in bile salt based therapies: A critical overview Biochemical pharmacology 2019;161:1-13 [PubMed]
  • Qu Changbo, Li Yang, Li Yunlong, Yu Peifa, Li Pengfei, Donkers Joanne M., van de Graaf Stan F. J., de Man Robert A., Peppelenbosch Maikel P., Pan Qiuwei FDA-drug screening identifies deptropine inhibiting hepatitis E virus involving the NF-κB-RIPK1-caspase axis Antiviral research 2019;170 [PubMed]
  • Hohenester Simon D. Fibrosing cholangiopathies: Novel pathophysiological concepts 2019. 235p. ISBN 9783000620621. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Beuers U. H. W. , Oude Elferink R. P. J.; Co-supervisor: van de Graaf K. F. J.)
  • Slijepčević Davor Hepatic bile salt uptake: The role of NTCP revisited 2019. 159p. ISBN 9789492801685. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Beuers U. H. W. , Oude Elferink R. P. J. , van de Graaf K. F. J.)
  • van de Wiel Sandra M.W., Bijsmans Ingrid T.G.W., van Mil Saskia W.C., van de Graaf Stan F.J. Identification of FDA-approved drugs targeting the Farnesoid X Receptor Scientific reports 2019;9 (1) [PubMed]
  • Donkers Joanne, Appelman Monique, van de Graaf Konstantijn Mechanistic insights into the inhibition of NTCP by myrcludex B JHEP Reports 2019;1 (4):278-285
  • Roscam Abbing Reinout L. P. Modulation of hepatic bile salt uptake potential therapeutic applications 2019. 189p. ISBN 9789461829702. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van de Graaf K. F. J. , Oude Elferink R. P. J.; Co-supervisor: Beuers U. H. W.)
  • Donkers Joanne M., Kooijman Sander, Slijepcevic Davor, Kunst Roni F., Roscam Abbing Reinout L. P., Haazen Lizette, de Waart Dirk R., Levels Johannes H. M., Schoonjans Kristina, Rensen Patrick C. N., Oude Elferink Ronald P. J., van de Graaf Stan F. J. NTCP deficiency in mice protects against obesity and hepatosteatosis JCI insight 2019;4 (14) [PubMed]
  • Donkers Joanne M. Targeting hepatic bile salt uptake to treat obesity-related metabolic disorders 2019. 175p. ISBN 9789461829733. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van de Graaf K. F. J. , Oude Elferink R. P. J.)

2018

  • Hubers Lowiek M., Vos Harmjan, Schuurman Alex R., Erken Robin, Oude Elferink Ronald P., Burgering Boudewijn, van de Graaf Stan F. J., Beuers Ulrich Annexin A11 is targeted by IgG4 and IgG1 autoantibodies in IgG4-related disease Gut 2018;67 (4):728-735 [PubMed]
  • van de Wiel Sandra M. W., van de Graaf Stan F. J. Bile acid dependent and independent roles of fibroblast growth factor 15/19 in liver regeneration AME Medical Journal 2018;3:95
  • Chen Chen, Jochems Paulus G. M., Salz Lucia, Schneeberger Kerstin, Penning Louis C., van de Graaf Stan F. J., Beuers Ulrich, Clevers Hans, Geijsen Niels, Masereeuw Rosalinde, Spee Bart Bioengineered bile ducts recapitulate key cholangiocyte functions BIOFABRICATION 2018;10 (3) [PubMed]
  • Robin Marion J D, Appelman Monique D, Vos Harmjan R, van Es Robert M, Paton James C, Paton Adrienne W, Burgering Boudewijn, Fickert Peter, Heijmans Jarom, van de Graaf Stan F J Calnexin Depletion by Endoplasmic Reticulum Stress During Cholestasis Inhibits the Na+-Taurocholate Cotransporting Polypeptide Hepatology Communications 2018;2 (12):1550-1566 [PubMed]
  • van de Wiel Sandra M. W., de Waart D. Rudi, Oude Elferink Ronald P. J., van de Graaf Stan F. J. Intestinal Farnesoid X Receptor Activation by Pharmacologic Inhibition of the Organic Solute Transporter α-β Cellular and molecular gastroenterology and hepatology 2018;5 (3):223-237 [PubMed]
  • Slijepcevic Davor, Roscam Abbing Reinout L. P., Fuchs Claudia D., Haazen Lizette C. M., Beuers Ulrich, Trauner Michael, Oude Elferink Ronald P. J., van de Graaf Stan F. J. Na+-taurocholate cotransporting polypeptide inhibition has hepatoprotective effects in cholestasis in mice Hepatology (Baltimore, Md.) 2018;68 (3):1057-1069 [PubMed]
  • Trampert David C., Hubers Lowiek M., van de Graaf Stan F. J., Beuers Ulrich On the role of IgG4 in inflammatory conditions: lessons for IgG4-related disease BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS 2018;1864 (4B):1401-1409 [PubMed]
  • van de Graaf S. F. J., Slijepcevic Davor Reply Hepatology (Baltimore, Md.) 2018;67 (3):1185-1186 [PubMed]
  • Roscam Abbing Reinout L. P., de Lannoy Larissa M., van de Graaf Stan F. J. The case for combining treatments for primary sclerosing cholangitis lancet. Gastroenterology & hepatology 2018;3 (8):526-528
  • Scalet Daniela, Sacchetto Claudia, Bernardi Francesco, Pinotti Mirko, van de Graaf Stan F. J., Balestra Dario The somatic FAH C.1061C>A change counteracts the frequent FAH c.1062+5G>A mutation and permits U1snRNA-based splicing correction Journal of human genetics 2018;63:683-686 [PubMed]

2017

  • Slijepcevic Davor, van de Graaf Stan F. J. Bile Acid Uptake Transporters as Targets for Therapy Digestive diseases (Basel, Switzerland) 2017;35 (3):251-258 [PubMed]
  • van Dijk Remco, Aronson Sem J., de Waart Dirk R., van de Graaf Stan F., Duijst Suzanne, Seppen Jurgen, Oude Elferink Ronald, Beuers Ulrich, Bosma Piter J. Biliverdin Reductase inhibitors did not improve severe unconjugated hyperbilirubinemia in vivo Scientific reports 2017;7 (1):1646 [PubMed]
  • van der Woerd Wendy L., Houwen Roderick Hj, van de Graaf Stan Fj Current and future therapies for inherited cholestatic liver diseases World journal of gastroenterology 2017;23 (5):763-775 [PubMed]
  • Slijepcevic Davor, Roscam Abbing Reinout L. P., Katafuchi Takeshi, Blank Antje, Donkers Joanne M., van Hoppe Stéphanie, de Waart Dirk R., Tolenaars Dagmar, van der Meer Jonathan H. M., Wildenberg Manon, Beuers Ulrich, Oude Elferink Ronald P. J., Schinkel Alfred H., van de Graaf Stan F. J. Hepatic Uptake of Conjugated Bile Acids Is Mediated by Both Sodium Taurocholate Cotransporting Polypeptide and Organic Anion Transporting Polypeptides and Modulated by Intestinal Sensing of Plasma Bile Acid Levels in Mice Hepatology (Baltimore, Md.) 2017;66 (5):1631-1643 [PubMed]
  • Maroni Luca, Hohenester Simon D., van de Graaf Stan F. J., Tolenaars Dagmar, van Lienden Krijn, Verheij Joanne, Marzioni Marco, Karlsen Tom H., Oude Elferink Ronald P. J., Beuers Ulrich Knockout of the primary sclerosing cholangitis-risk gene Fut2 causes liver disease in mice Hepatology (Baltimore, Md.) 2017;66 (2):542-554 [PubMed]
  • Appelman Monique D., Chakraborty Anindita, Protzer Ulrike, McKeating Jane A., van de Graaf Stan F. J. N-Glycosylation of the Na+-Taurocholate Cotransporting Polypeptide (NTCP) Determines Its Trafficking and Stability and Is Required for Hepatitis B Virus Infection PLoS ONE 2017;12 (1):e0170419 [PubMed]
  • Donkers Joanne M., Zehnder Benno, van Westen Gerard J. P., Kwakkenbos Mark J., IJzerman Adriaan P., Oude Elferink Ronald P. J., Beuers Ulrich, Urban Stephan, van de Graaf Stan F. J. Reduced hepatitis B and D viral entry using clinically applied drugs as novel inhibitors of the bile acid transporter NTCP Scientific reports 2017;7 (1):15307 [PubMed]
  • Kersseboom Simone, van Gucht Anja L. M., van Mullem Alies, Brigante Giulia, Farina Stefania, Carlsson Bo, Donkers Joanne M., van de Graaf Stan F. J., Peeters Robin P., Visser Theo J. Role of the Bile Acid Transporter SLC10A1 in Liver Targeting of the Lipid-Lowering Thyroid Hormone Analog Eprotirome Endocrinology 2017;158 (10):3307-3318 [PubMed]

2016

  • Doorenspleet Marieke E., Hubers Lowiek M., Culver Emma L., Maillette de Buy Wenniger Lucas J., Klarenbeek Paul L., Chapman Roger W., Baas Frank, van de Graaf Stan F., Verheij Joanne, van Gulik Thomas M., Barnes Eleanor, Beuers Ulrich, de Vries Niek Immunoglobulin G4(+) B-cell receptor clones distinguish immunoglobulin G 4-related disease from primary sclerosing cholangitis and biliary/pancreatic malignancies Hepatology (Baltimore, Md.) 2016;64 (2):501-507 [PubMed]
  • Meredith L. W., Hu K., Cheng X., Howard C. R., Baumert T. F., Balfe P., van de Graaf K. F., Protzer U., McKeating J. A. Lentiviral hepatitis B pseudotype entry requires sodium taurocholate co-transporting polypeptide and additional hepatocyte-specific factors Journal of general virology 2016;97 (1):121-127 [PubMed]
  • van de Wiel Sandra, Merkx Maarten, van de Graaf Stan Real Time Monitoring of Intracellular Bile Acid Dynamics Using a Genetically Encoded FRET-based Bile Acid Sensor Journal of visualized experiments 2016 (107) [PubMed]
  • van der Woerd Wendy L., Wichers Catharina G. K., Vestergaard Anna L., Andersen Jens Peter, Paulusma Coen C., Houwen Roderick H. J., van de Graaf Stan F. J. Rescue of defective ATP8B1 trafficking by CFTR correctors as a therapeutic strategy for familial intrahepatic cholestasis Journal of hepatology 2016;64 (6):1339-1347 [PubMed]

2015

  • van der Woerd Wendy L., Mulder Johanna, Pagani Franco, Beuers Ulrich, Houwen Roderick H. J., van de Graaf Stan F. J. Analysis of aberrant pre-messenger RNA splicing resulting from mutations in ATP8B1 and efficient in vitro rescue by adapted U1 small nuclear RNA Hepatology (Baltimore, Md.) 2015;61 (4):1382-1391 [PubMed]
  • van der Woerd Wendy Lia ATP8B1 deficiency: Steps towards personalized therapy 2015. 159p. ISBN 9789462598829. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Beuers U. H. W.; Co-supervisors: Houwen R. H. J., van de Graaf K. F. J.)
  • Bruurs Lucas J. M., Donker Lisa, Zwakenberg Susan, Zwartkruis Fried J., Begthel Harry, Knisely A. S., Posthuma George, van de Graaf Stan F. J., Paulusma Coen C., Bos Johannes L. ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization Journal of cell biology 2015;210 (7):1055-1063 [PubMed]
  • Kasteleijn-Nolst Trenité Dorothée G. A., Volkers Linda, Strengman Eric, Schippers Herman M., Perquin Willem, de Haan Gerrit-Jan, Gkountidi Anastasia O., van't Slot Ruben, van de Graaf Stan F., de Graaf Stan F., Jocic-Jakubi Bosanka, Capovilla Giuseppe, Covanis Athanasios, Parisi Pasquale, Veggiotti Pierangelo, Brinciotti Mario, Incorpora Gemma, Piccioli Marta, Cantonetti Laura, Berkovic Samuel F., Scheffer Ingrid E., Brilstra Eva H., Sonsma Anja C. M., Bader Adri J., de Kovel Carolien G. F., Koeleman Bobby P. C. Clinical and genetic analysis of a family with two rare reflex epilepsies Seizure 2015;29:90-96 [PubMed]
  • Trenite Dorothee G. A. Kasteleijn-Nolst, Volkers Linda, Strengman Eric, Schippers Herman M., Perquin Willem, de Haan Gerrit-Jan, Gkountidi Anastasia O., van't Slot Ruben, van de Graaf Stan F., Jocic-Jakubi Bosanka, Capovilla Giuseppe, Covanis Athanasios, Parisi Pasquale, Veggiotti Pierangelo, Brinciotti Mario, Incorpora Gemma, Piccioli Marta, Cantonetti Laura, Berkovic Samuel F., Scheffer Ingrid E., Brilstra Eva H., Sonsma Anja C. M., Bader Adri J., de Kovel Carolien G. F., Koeleman Bobby P. C. Clinical and genetic analysis of a family with two rare reflex epilepsies (vol 29, pg 90, 2015) Seizure 2015;33:104
  • Maroni Luca, van de Graaf Stan F. J., Hohenester Simon D., Oude Elferink Ronald P. J., Beuers Ulrich Fucosyltransferase 2: a genetic risk factor for primary sclerosing cholangitis and Crohn's disease--a comprehensive review Clinical reviews in allergy & immunology 2015;48 (2-3):182-191 [PubMed]
  • Hubers Lowiek M., Maillette de Buy Wenniger Lucas J., Doorenspleet Marieke E., Klarenbeek Paul L., Verheij Joanne, Rauws Erik A., van Gulik Thomas M., Oude Elferink Ronald P. J., van de Graaf Stan F. J., de Vries Niek, Beuers Ulrich IgG4-associated cholangitis: a comprehensive review Clinical reviews in allergy & immunology 2015;48 (2-3):198-206 [PubMed]
  • Slijepcevic Davor, Kaufman Christina, Wichers Catharina G. K., Gilglioni Eduardo H., Lempp Florian A., Duijst Suzanne, de Waart Dirk R., Elferink Ronald P. J. Oude, Mier Walter, Stieger Bruno, Beuers Ulrich, Urban Stephan, van de Graaf Stan F. J. Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na(+) -taurocholate cotransporting polypeptide knockout mice Hepatology (Baltimore, Md.) 2015;62 (1):207-219 [PubMed]

2014

  • van de Graaf Stan, Beuers Ulrich Autophagy - another piece of the puzzle towards understanding primary biliary cirrhosis? Liver international 2014;34 (4):481-483 [PubMed]
  • Beuers Ulrich, Maillette de Buy Wenniger Lucas J., Doorenspleet Marieke, Hubers Lowiek, Verheij Joanne, van Gulik Thomas, van de Graaf Stan F. J., de Vries Niek IgG4-associated cholangitis Digestive diseases (Basel, Switzerland) 2014;32 (5):605-608 [PubMed]
  • Lindenburg Laurens H., Malisauskas Mantas, Sips Tari, van Oppen Lisanne, Wijnands Sjors P. W., van de Graaf Stan F. J., Merkx Maarten Quantifying stickiness: thermodynamic characterization of intramolecular domain interactions to guide the design of förster resonance energy transfer sensors Biochemistry 2014;53 (40):6370-6381 [PubMed]

2013

  • Gao Yuan, Koppen Arjen, Rakhshandehroo Maryam, Tasdelen Ismayil, van de Graaf Stan F., van Loosdregt Jorg, van Beekum Olivier, Hamers Nicole, van Leenen Dik, Berkers Celia R., Berger Ruud, Holstege Frank C. P., Coffer Paul J., Brenkman Arjan B., Ovaa Huib, Kalkhoven Eric Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60 Nature communications 2013;4:2656 [PubMed]
  • van der Velden Lieke M., Golynskiy Misha V., Bijsmans Ingrid T. G. W., van Mil Saskia W. C., Klomp Leo W. J., Merkx Maarten, van de Graaf Stan F. J. Monitoring bile acid transport in single living cells using a genetically encoded Förster resonance energy transfer sensor Hepatology (Baltimore, Md.) 2013;57 (2):740-752 [PubMed]
  • van der Woerd Wendy L., van Haaften-Visser Désirée Y., van de Graaf Stan F. J., Férec Claude, Masson Emmanuelle, Stapelbroek Janneke M., Bugert Peter, Witt Heiko, Houwen Roderick H. J. Mutational Analysis of ATP8B1 in Patients with Chronic Pancreatitis PLoS ONE 2013;8 (11):e80553 [PubMed]

2012

  • Bijsmans Ingrid T. G. W., Bouwmeester Rianne A. M., Geyer Joachim, Faber Klaas Nico, van de Graaf Stan F. J. Homo- and hetero-dimeric architecture of the human liver Na⁺-dependent taurocholate co-transporting protein Biochemical journal 2012;441 (3):1007-1015 [PubMed]
  • Schipper Henk S., Rakhshandehroo Maryam, van de Graaf Stan F. J., Venken Koen, Koppen Arjen, Stienstra Rinke, Prop Serge, Meerding Jenny, Hamers Nicole, Besra Gurdyal, Boon Louis, Nieuwenhuis Edward E. S., Elewaut Dirk, Prakken Berent, Kersten Sander, Boes Marianne, Kalkhoven Eric Natural killer T cells in adipose tissue prevent insulin resistance Journal of clinical investigation 2012;122 (9):3343-3354 [PubMed]

2010

  • van der Velden Lieke M., van de Graaf Stan F. J., Klomp Leo W. J. Biochemical and cellular functions of P4 ATPases Biochemical journal 2010;431 (1):1-11 [PubMed]
  • van der Woerd Wendy L., van Mil Saskia W. C., Stapelbroek Janneke M., Klomp Leo W. J., van de Graaf Stan F. J., Houwen Roderick H. J. Familial cholestasis: progressive familial intrahepatic cholestasis, benign recurrent intrahepatic cholestasis and intrahepatic cholestasis of pregnancy Best practice & research. Clinical gastroenterology 2010;24 (5):541-553 [PubMed]
  • van der Velden Lieke M., Stapelbroek Janneke M., Krieger Elmar, van den Berghe Peter V. E., Berger Ruud, Verhulst Patricia M., Holthuis Joost C. M., Houwen Roderick H. J., Klomp Leo W. J., van de Graaf Stan F. J. Folding defects in P-type ATP 8B1 associated with hereditary cholestasis are ameliorated by 4-phenylbutyrate Hepatology (Baltimore, Md.) 2010;51 (1):286-296 [PubMed]
  • van der Velden Lieke M., Wichers Catharina G. K., van Breevoort Adriana E. D., Coleman Jonathan A., Molday Robert S., Berger Ruud, Klomp Leo W. J., van de Graaf Stan F. J. Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases Journal of biological chemistry 2010;285 (51):40088-40096 [PubMed]

2009

  • Schoeber Joost P. H., van de Graaf Stan F. J., Lee Kyu Pil, Wittgen Hanneke G. M., Hoenderop Joost G. J., Bindels René J. M. Conditional fast expression and function of multimeric TRPV5 channels using Shield-1 American journal of physiology. Renal physiology 2009;296 (1):F204-F211 [PubMed]
  • van den Berghe Peter V. E., Stapelbroek Janneke M., Krieger Elmar, de Bie Prim, van de Graaf Stan F. J., de Groot Reinoud E. A., van Beurden Ellen, Spijker Ellen, Houwen Roderick H. J., Berger Ruud, Klomp Leo W. J. Reduced expression of ATP7B affected by Wilson disease-causing mutations is rescued by pharmacological folding chaperones 4-phenylbutyrate and curcumin Hepatology (Baltimore, Md.) 2009;50 (6):1783-1795 [PubMed]

2008

  • van de Graaf Stan F. J., Rescher Ursula, Hoenderop Joost G. J., Verkaart Sjoerd, Bindels René J. M., Gerke Volker TRPV5 is internalized via clathrin-dependent endocytosis to enter a Ca2+-controlled recycling pathway Journal of biological chemistry 2008;283 (7):4077-4086 [PubMed]

2007

  • van de Graaf S. F. J., Bindels R. J. M., Hoenderop J. G. J. Physiology of epithelial Ca2+ and Mg2+ transport Reviews of physiology, biochemistry and pharmacology 2007;158:77-160 [PubMed]

2006

  • van de Graaf Stan F. J., Chang Qing, Mensenkamp Arjen R., Hoenderop Joost G. J., Bindels René J. M. Direct interaction with Rab11a targets the epithelial Ca2+ channels TRPV5 and TRPV6 to the plasma membrane Molecular and cellular biology 2006;26 (1):303-312 [PubMed]
  • van de Graaf Stan F. J., van der Kemp Annemiete W. C. M., van den Berg Dennis, van Oorschot Mijke, Hoenderop Joost G. J., Bindels René J. M. Identification of BSPRY as a novel auxiliary protein inhibiting TRPV5 activity Journal of the American Society of Nephrology 2006;17 (1):26-30 [PubMed]
  • van de Graaf Stan F. J., Hoenderop Joost G. J., van der Kemp Annemiete W. C. M., Gisler Serge M., Bindels René J. M. Interaction of the epithelial Ca2+ channels TRPV5 and TRPV6 with the intestine- and kidney-enriched PDZ protein NHERF4 Pflugers Archiv 2006;452 (4):407-417 [PubMed]
  • van de Graaf Stan F. J., Hoenderop Joost G. J., Bindels René J. M. Regulation of TRPV5 and TRPV6 by associated proteins American journal of physiology. Renal physiology 2006;290 (6):F1295-F1302 [PubMed]

2005

  • den Dekker Els, Schoeber Joost, Topala Catalin N., van de Graaf Stan F. J., Hoenderop Joost G. J., Bindels René J. M. Characterization of a Madin-Darby canine kidney cell line stably expressing TRPV5 Pflugers Archiv 2005;450 (4):236-244 [PubMed]
  • Palmada Monica, Poppendieck Susanne, Embark Hamdy M., van de Graaf Stan F. J., Boehmer Christoph, Bindels René J. M., Lang Florian Requirement of PDZ domains for the stimulation of the epithelial Ca2+ channel TRPV5 by the NHE regulating factor NHERF2 and the serum and glucocorticoid inducible kinase SGK1 Cellular physiology and biochemistry 2005;15 (1-4):175-182 [PubMed]

2004

  • Chang Qing, Gyftogianni Emmanouela, van de Graaf Stan F. J., Hoefs Susan, Weidema Freek A., Bindels René J. M., Hoenderop Joost G. J. Molecular determinants in TRPV5 channel assembly Journal of biological chemistry 2004;279 (52):54304-54311 [PubMed]
  • van de Graaf Stan F. J., Boullart Inge, Hoenderop Joost G. J., Bindels René J. M. Regulation of the epithelial Ca2+ channels TRPV5 and TRPV6 by 1alpha,25-dihydroxy Vitamin D3 and dietary Ca2+ Journal of steroid biochemistry and molecular biology 2004;89-90 (1-5):303-308 [PubMed]
  • Embark Hamdy M., Setiawan Iwan, Poppendieck Susanne, van de Graaf Stan F. J., Boehmer Christoph, Palmada Monica, Wieder Thomas, Gerstberger Ruediger, Cohen Philip, Yun C. Chris, Bindels René J. M., Lang Florian Regulation of the epithelial Ca2+ channel TRPV5 by the NHE regulating factor NHERF2 and the serum and glucocorticoid inducible kinase isoforms SGK1 and SGK3 expressed in Xenopus oocytes Cellular physiology and biochemistry 2004;14 (4-6):203-212 [PubMed]

2003

  • van de Graaf Stan F. J., Hoenderop Joost G. J., Gkika Dimitra, Lamers Dennis, Prenen Jean, Rescher Ursula, Gerke Volker, Staub Olivier, Nilius Bernd, Bindels René J. M. Functional expression of the epithelial Ca2+ channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex EMBO journal 2003;22 (7):1478-1487 [PubMed]

2001

  • Danahay H., Withey L., Poll C. T., van de Graaf S. F., Bridges R. J. Protease-activated receptor-2-mediated inhibition of ion transport in human bronchial epithelial cells American journal of physiology. Cell physiology 2001;280 (6):C1455-C1464 [PubMed]

1999

  • Hoenderop J. G., van der Kemp A. W., Hartog A., van de Graaf S. F., van Os C. H., Willems P. H., Bindels R. J. Molecular identification of the apical Ca2+ channel in 1,25-dihydroxyvitamin D-3-responsive epithelia Journal of biological chemistry 1999;274 (13):8375-8378 [PubMed]
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