M. Engelen PhD publications

foto

Publications PhD M. Engelen

Position
Medical Specialist
Main activities
Patient care, Research
Specialisation
(pediatric) neurology
Focus of research

Peroxisomal metabolic disorders

Leukodystrophies

 

The Department of Pediatric Neurology is a subdivision of the Department of Neurology and the Department of Pediatrics. The research program of the department is focused on clinical and translational research concerning leukodystrophies and neonatal neurology. These two main themes are imbedded in the nine translational research programs of Amsterdam Neuroscience, the research institute of neuroscience investigators in the Amsterdam area. All staff members of the Department of Pediatric Neurology are involved in research and collaborate within Neuroscience Amsterdam, with other academic and non-academic hospitals, and with international research groups.

 

Leukodystrophies

 

As expertise center for leukodystrophies in The Netherlands, the department has a long tradition in clinical characterization of large cohorts of leukodystrophy patients, studies with advanced MRI techniques and gene finding studies. There is close collaboration with laboratory scientists. Cell and mouse models are used to study pathophysiology of leukodystrophies. Several clinical trials have been performed the past decade and it is our ambition to be a center for large multicenter international trials. There is specific emphasis on:

 

  1. Vanishing white matter and metachromatic leukodystrophy
  2. Hypomyelinating disorders like 4H syndrome and Pelizaeus Merzbacher disease
  3. Peroxisomal disorders, specifically X-linked adrenoleukodystrophy and Zellweger spectrum disorders
  4. Defects of white matter ion and water homeostasis

 

 

2020

  • Barendsen Rinse W., Dijkstra Inge M. E., Visser Wouter F., Alders Mariëlle, Bliek Jet, Boelen Anita, Bouva Marelle J., van der Crabben Saskia N., Elsinghorst Ellen, van Gorp Ankie G. M., Heijboer Annemieke C., Jansen Mandy, Jaspers Yorrick R. J., van Lenthe Henk, Metgod Ingrid, Mooij Christiaan F., van der Sluijs Elise H. C., van Trotsenburg A. S. Paul, Verschoof-Puite Rendelien K., Vaz Frédéric M., Waterham Hans R., Wijburg Frits A., Engelen Marc, Dekkers Eugènie, Kemp Stephan Adrenoleukodystrophy Newborn Screening in the Netherlands (SCAN Study): The X-Factor Frontiers in cell and developmental biology 2020;8 [PubMed]
  • Mallack Eric J., van de Stadt Stephanie, Caruso Paul A., Musolino Patricia L., Sadjadi Reza, Engelen Marc, Eichler Florian S. Clinical and radiographic course of arrested cerebral adrenoleukodystrophy Neurology 2020;94 (24):e2499-e2507 [PubMed]
  • Fallatah Wedad, Schouten Monica, Yergeau Christine, di Pietro Erminia, Engelen Marc, Waterham Hans R., Poll-The Bwee Tien, Braverman Nancy Clinical, biochemical, and molecular characterization of mild (nonclassic) rhizomelic chondrodysplasia punctata Journal of inherited metabolic disease 2020 [PubMed]
  • Jaspers Yorrick R. J., Ferdinandusse Sacha, Dijkstra Inge M. E., Barendsen Rinse Willem, van Lenthe Henk, Kulik Wim, Engelen Marc, Goorden Susan M. I., Vaz Frédéric M., Kemp Stephan Comparison of the Diagnostic Performance of C26:0-Lysophosphatidylcholine and Very Long-Chain Fatty Acids Analysis for Peroxisomal Disorders Frontiers in cell and developmental biology 2020;8 [PubMed]
  • van Ballegoij Wouter J. C., Kuijpers Sander C., Huffnagel Irene C., Weinstein Henry C., Poll‑The Bwee Tien, Engelen Marc, Bennebroek Carlien A. M., Verbraak Frank D. Correction to: Optical coherence tomography shows neuroretinal thinning in myelopathy of adrenoleukodystrophy (Journal of Neurology, (2020), 267, 3, (679-687), 10.1007/s00415-019-09627-z) Journal of neurology 2020;267 (8):2484 [PubMed]
  • Welsink-Karssies Mendy M., Ferdinandusse Sacha, Geurtsen Gert J., Hollak Carolina E. M., Huidekoper Hidde H., Janssen Mirian C. H., Langendonk Janneke G., van der Lee Hanneke H., O'Flaherty Roisin, Oostrom Kim J., Roosendaal Stefan D., Rubio-Gozalbo M. Estela, Saldova Radka, Treacy Eileen P., Vaz Fred M., de Vries Maaike C., Engelen Marc, Bosch Antonette M. Deep phenotyping classical galactosemia: clinical outcomes and biochemical markers Brain Communications 2020;2 (1) [PubMed]
  • Montoro Roberto, Heine Vivi M., Kemp Stephan, Engelen Marc Evolution of adrenoleukodystrophy model systems Journal of inherited metabolic disease 2020 [PubMed]
  • Carlson Aaron M., Huffnagel Irene C., Verrips Aad, van der Knaap Marjo S., Engelen Marc, van Haren Keith Five men with arresting and relapsing cerebral adrenoleukodystrophy Journal of neurology 2020 [PubMed]
  • Welsink-Karssies Mendy M., Schrantee Anouk, Caan Matthan W. A., Hollak Carla E. M., Janssen Mirian C. H., Oussoren Esmee, de Vries Maaike C., Roosendaal Stefan D., Engelen Marc, Bosch Annet M. Gray and white matter are both affected in classical galactosemia: An explorative study on the association between neuroimaging and clinical outcome Molecular genetics and metabolism 2020;131 (4):370-379 [PubMed]
  • Hoytema van Konijnenburg Eva M. M., Luirink Ilse K., Schagen Sebastian E. E., Engelen Marc, Berendse Kevin, Poll-The Bwee Tien, Chegary Malika Hyperinsulinism in a patient with a Zellweger Spectrum Disorder and a 16p11.2 deletion syndrome Molecular genetics and metabolism reports 2020;23 [PubMed]
  • Richmond Phillip A., van der Kloet Frans, Vaz Frederic M., Lin David, Uzozie Anuli, Graham Emma, Kobor Michael, Mostafavi Sara, Moerland Perry D., Lange Philipp F., van Kampen Antoine H. C., Wasserman Wyeth W., Engelen Marc, Kemp Stephan, van Karnebeek Clara D. M. Multi-Omic Approach to Identify Phenotypic Modifiers Underlying Cerebral Demyelination in X-Linked Adrenoleukodystrophy Frontiers in cell and developmental biology 2020;8 [PubMed]
  • van Ballegoij Wouter J. C., Kuijpers Sander C., Huffnagel Irene C., Weinstein Henry C., Poll-The Bwee Tien, Engelen Marc, Bennebroek Carlien A. M., Verbraak Frank D. Optical coherence tomography shows neuroretinal thinning in myelopathy of adrenoleukodystrophy Journal of neurology 2020;267 (3):679–687 [PubMed]
  • van Ballegoij Wouter J. C., van de Stadt Stephanie I. W., Huffnagel Irene C., Kemp Stephan, Willemse Eline A. J., Teunissen Charlotte E., Engelen Marc Plasma NfL and GFAP as biomarkers of spinal cord degeneration in adrenoleukodystrophy Annals of clinical and translational neurology 2020;7 (11):2127-2136 [PubMed]
  • van Ballegoij Wouter J. C., van de Stadt Stephanie I. W., Huffnagel Irene C., Kemp Stephan, van der Knaap Marjo S., Engelen Marc Postural Body Sway as Surrogate Outcome for Myelopathy in Adrenoleukodystrophy Frontiers in physiology 2020;11 [PubMed]
  • Vaz Frédéric M., McDermott John H., Engelen Marc, Banka Siddharth Reply: Expanding the clinical and genetic spectrum of PCYT2-related disorders Brain 2020;143 (9):1-2 [PubMed]
  • van de Stadt Stephanie I. W., van Ballegoij Wouter J. C., Labounek René, Huffnagel Irene C., Kemp Stephan, Nestrasil Igor, Engelen Marc Spinal cord atrophy as a measure of severity of myelopathy in adrenoleukodystrophy Journal of inherited metabolic disease 2020;43 (4):852-860 [PubMed]
  • Garrelfs Mark R., Takada Sanami, Kamsteeg Erik-Jan, Pegge Sjoert, Mancini Grazia, Engelen Marc, van de Warrenburg Bart, Rennings Alexander, van Gaalen Judith, Peters Ivo, Weemaes Corry, van der Burg Mirjam, Willemsen Michèl A. The Phenotypic Spectrum of PNKP-Associated Disease and the Absence of Immunodeficiency and Cancer Predisposition in a Dutch Cohort Pediatric neurology 2020;113:26-32 [PubMed]
  • van Karnebeek Clara D. M., Richmond Phillip A., van der Kloet Frans, Wasserman Wyeth W., Engelen Marc, Kemp Stephan The variability conundrum in neurometabolic degenerative diseases Molecular genetics and metabolism 2020;131 (4):367-369 [PubMed]

2019

  • Huffnagel Irene C., Dijkgraaf Marcel G. W., Janssens Georges E., van Weeghel Michel, van Geel Björn M., Poll-The Bwee Tien, Kemp Stephan, Engelen Marc Disease progression in women with X-linked adrenoleukodystrophy is slow Orphanet journal of rare diseases 2019;14 (1) [PubMed]
  • Berendse Kevin, Koot Bart G. P., Klouwer Femke C. C., Engelen Marc, Roels Frank, Lacle Miangela M., Nikkels Peter G. J., Verheij Joanne, Poll-The Bwee Tien Hepatic symptoms and histology in 13 patients with a Zellweger spectrum disorder Journal of inherited metabolic disease 2019;42 (5):955-965 [PubMed]
  • Huffnagel Irene C. Life unexpected: Unraveling the natural history of adrenoleukodystrophy 2019. 232p. ISBN 9789463612586. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Poll-The B. T. , Kemp S.; Co-supervisor: Engelen M.)
  • Huffnagel Irene C, van Ballegoij Wouter J C, Vos Johanna M B W, Kemp Stephan, Caan Matthan W A, Engelen Marc Longitudinal diffusion MRI as surrogate outcome measure for myelopathy in adrenoleukodystrophy Neurology 2019;93 (23):e2133-e2143 [PubMed]
  • Buis D. R. , Jiya T. , van den Berg R., Engelen Marc, Bouma P. , Slot Kari-anne, Hoefnagels F. W. , Wouda E. J., Bouma G. J. Lumbale hernia nuclei pulposi bij kinderen Tijdschrift voor neurologie en neurochirurgie 2019;120 (5):174-181
  • van Haren Keith, Engelen Marc, Wolf Nicole Measuring early lesion growth in boys with cerebral demyelinating adrenoleukodystrophy Neurology 2019;92 (15):691-693 [PubMed]
  • Vaz Frédéric M., McDermott John H., Alders Mariëlle, Wortmann Saskia B., Kölker Stefan, Pras-Raves Mia L., Vervaart Martin A. T., van Lenthe Henk, Luyf Angela C. M., Elfrink Hyung L., Metcalfe Kay, Cuvertino Sara, Clayton Peter E., Yarwood Rebecca, Lowe Martin P., Lovell Simon, Rogers Richard C., van Kampen Antoine H. C., Ruiter Jos P. N., Wanders Ronald J. A., Ferdinandusse Sacha, van Weeghel Michel, Engelen Marc, Banka Siddharth Mutations in PCYT2 disrupt etherlipid biosynthesis and cause a complex hereditary spastic paraplegia Brain 2019;142 (11):3382-3397 [PubMed]
  • Buermans Noortje J. M. L., van den Bosch Sharon J. G., Huffnagel Irene C., Steenweg Marjan E., Engelen Marc, Oostrom Kim J., Geurtsen Gert J. Overall intact cognitive function in male X-linked adrenoleukodystrophy adults with normal MRI Orphanet journal of rare diseases 2019;14 (1):217 [PubMed]
  • Huffnagel Irene C., van Ballegoij Wouter J. C., van Geel Björn M., Vos Johanna M. B. W., Kemp Stephan, Engelen Marc Progression of myelopathy in males with adrenoleukodystrophy: towards clinical trial readiness Brain 2019;142 (2):334-343 [PubMed]
  • Klouwer Femke C. C., Koot Bart G. P., Berendse Kevin, Kemper Elles M., Ferdinandusse Sacha, Koelfat Kiran V. K., Lenicek Martin, Vaz Frédéric M., Engelen Marc, Jansen Peter L. M., Wanders Ronald J. A., Waterham Hans R., Schaap Frank G., Poll-The Bwee Tien The cholic acid extension study in Zellweger spectrum disorders: Results and implications for therapy Journal of inherited metabolic disease 2019;42 (2):303-312 [PubMed]
  • Huffnagel Irene C., Laheji Fiza K., Aziz-Bose Razina, Tritos Nicholas A., Marino Rose, Linthorst Gabor E., Kemp Stephan, Engelen Marc, Eichler Florian The natural history of adrenal insufficiency in X-linked adrenoleukodystrophy: An international collaboration Journal of clinical endocrinology and metabolism 2019;104 (1):118-126 [PubMed]
  • den Besten Milou, Engelen Marc, Sas Theo C. J., van Trotsenburg A. S. Paul, Zwaveling-Soonawala Nitash Thiamazole-Associated Neuropathy Thyroid 2019;29 (5):748-749 [PubMed]

2018

  • Zeynelabidin Sara, Klouwer Femke C. C., Meijers Joost C. M., Suijker Monique H., Engelen Marc, Poll-The Bwee Tien, van Ommen C. Heleen Coagulopathy in Zellweger spectrum disorders: a role for vitamin K Journal of inherited metabolic disease 2018;41 (2):249-255 [PubMed]
  • Bosch Annet M., Kamsteeg Erik-Jan, Rodenburg Richard J., van Deutekom Arend W., Buis Dennis R., Engelen Marc, Cobben Jan-Maarten Coenzyme Q10 deficiency due to a COQ4 gene defect causes childhood-onset spinocerebellar ataxia and stroke-like episodes Molecular genetics and metabolism reports 2018;17:19-21 [PubMed]
  • Engelen Marc, Kemp Stephan Een andere hielprik voor jongens dan voor meisjes?in: Riekelt Houtkooper, editors. De hielprik. Stichting Biowetenschappen en Maatschappij; 2018. p. -
  • de Mol C. L., Wong Y. Y. M., van Pelt E. D., Ketelslegers I. A., Bakker D. P., Boon M., Braun K. P. J., van Dijk K. G. J., Eikelenboom M. J., Engelen M., Geleijns K., Haaxma C. A., Niermeijer J. M. F., Niks E. H., Peeters E. A. J., Peeters-Scholte C. M. P. C. D., Poll-The B. T., Portier R. P., de Rijk-van Andel J. F., Samijn J. P. A., Schippers H. M., Snoeck I. N., Stroink H., Vermeulen R. J., Verrips A., Visscher F., Vles J. S. H., Willemsen M. A. A. P., Catsman-Berrevoets C. E., Hintzen R. Q., Neuteboom R. F. Incidence and outcome of acquired demyelinating syndromes in Dutch children: update of a nationwide and prospective study Journal of neurology 2018;265 (6):1310-1319 [PubMed]
  • Reijnders Margot R. F., Janowski Robert, Alvi Mohsan, Self Jay E., van Essen Ton J., Vreeburg Maaike, Rouhl Rob P. W., Stevens Servi J. C., Stegmann Alexander P. A., Schieving Jolanda, Pfundt Rolph, van Dijk Katinke, Smeets Eric, Stumpel Connie T. R. M., Bok Levinus A., Cobben Jan Maarten, Engelen Marc, Mansour Sahar, Whiteford Margo, Chandler Kate E., Douzgou Sofia, Cooper Nicola S., Tan Ene-Choo, Foo Roger, Lai Angeline H. M., Rankin Julia, Green Andrew, Lönnqvist Tuula, Isohanni Pirjo, Williams Shelley, Ruhoy Ilene, Carvalho Karen S., Dowling James J., Lev Dorit L., Sterbova Katalin, Lassuthova Petra, Neupauerová Jana, Waugh Jeff L., Keros Sotirios, Clayton-Smith Jill, Smithson Sarah F., Brunner Han G., van Hoeckel Ceciel, Anderson Mel, Clowes Virginia E., Siu Victoria Mok, Selber Paulo, Leventer Richard J., Nellaker Christoffer, Niessing Dierk, Hunt David, Baralle Diana PURA syndrome: clinical delineation and genotype-phenotype study in 32 individuals with review of published literature Journal of medical genetics 2018;55 (2):104-113 [PubMed]
  • Braakman Hilde M. H., Engelen Marc, Nicolai Joost, Willemsen Michèl A. A. P. Stroke mimics add to the phenotypic spectrum of GLUT1 deficiency syndrome Journal of neurology, neurosurgery, and psychiatry 2018;89 (6):668-670 [PubMed]
  • Klouwer Femke C. C. Zellweger spectrum disorders: From bench to bedside 2018. ISBN 9789462998391. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Waterham H. R., Poll-The B. T.; Co-supervisor: Engelen M.)

2017

  • Huffnagel Irene C., van de Beek Malu-Clair, Showers Amanda L., Orsini Joseph J., Klouwer Femke C. C., Dijkstra Inge M. E., Schielen Peter C., van Lenthe Henk, Wanders Ronald J. A., Vaz Frédéric M., Morrissey Mark A., Engelen Marc, Kemp Stephan Comparison of C26:0-carnitine and C26:0-lysophosphatidylcholine as diagnostic markers in dried blood spots from newborns and patients with adrenoleukodystrophy Molecular genetics and metabolism 2017;122 (4):209-215 [PubMed]
  • van Haren Keith, Engelen Marc Decision Making in Adrenoleukodystrophy When Is a Good Outcome Really a Good Outcome? JAMA Neurology 2017;74 (6):641-642 [PubMed]
  • van de Beek Malu-Clair, Ofman Rob, Dijkstra Inge, Wijburg Frits, Engelen Marc, Wanders Ronald, Kemp Stephan Lipid-induced endoplasmic reticulum stress in X-linked adrenoleukodystrophy BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2017;1863 (9):2255-2265 [PubMed]
  • Engelen Marc Optimizing Treatment for Cerebral Adrenoleukodystrophy in the Era of Gene Therapy New England journal of medicine 2017;377 (17):1682-1684 [PubMed]

2016

  • Kemp Stephan, Huffnagel Irene C., Linthorst Gabor E., Wanders Ronald J., Engelen Marc Adrenoleukodystrophy - neuroendocrine pathogenesis and redefinition of natural history Nature reviews. Endocrinology 2016;12 (10):606-615 [PubMed]
  • Koens L. H., Kuiper A., Coenen M. A., Elting J. W. J., de Vries J. J., Engelen M., Koelman J. H. T. M., van Spronsen F. J., Spikman J. M., de Koning T. J., Tijssen M. A. J. Ataxia, dystonia and myoclonus in adult patients with Niemann-Pick type C Orphanet journal of rare diseases 2016;11 (1):121 [PubMed]
  • van de Beek Malu-Clair, Dijkstra Inge M. E., van Lenthe Henk, Ofman Rob, Goldhaber-Pasillas Dalia, Schauer Nicolas, Schackmann Martin, Engelen-Lee Joo-Yeon, Vaz Frédéric M., Kulik Wim, Wanders Ronald J. A., Engelen Marc, Kemp Stephan C26:0-Carnitine Is a New Biomarker for X-Linked Adrenoleukodystrophy in Mice and Man PLoS ONE 2016;11 (4):e0154597 [PubMed]
  • Berendse Kevin, Klouwer Femke C. C., Koot Bart G. P., Kemper Elles M., Ferdinandusse Sacha, Koelfat Kiran V. K., Lenicek Martin, Schaap Frank G., Waterham Hans R., Vaz Frédéric M., Engelen Marc, Jansen Peter L. M., Wanders Ronald J. A., Poll-The Bwee Tien Cholic acid therapy in Zellweger spectrum disorders Journal of inherited metabolic disease 2016;39 (6):859-868 [PubMed]
  • Klouwer Femke C. C., Huffnagel Irene C., Ferdinandusse Sacha, Waterham Hans R., Wanders Ronald J. A., Engelen Marc, Poll-The Bwee Tien Clinical and Biochemical Pitfalls in the Diagnosis of Peroxisomal Disorders Neuropediatrics 2016;47 (4):205-220 [PubMed]
  • Schackmann Martin J. A., Ofman Rob, van Geel Björn M., Dijkstra Inge M. E., van Engelen Klaartje, Wanders Ronald J. A., Engelen Marc, Kemp Stephan Pathogenicity of novel ABCD1 variants: The need for biochemical testing in the era of advanced genetics Molecular genetics and metabolism 2016;118 (2):123-127 [PubMed]
  • Hollak Carla E. M., Biegstraaten Marieke, Baumgartner Matthias R., Belmatoug Nadia, Bembi Bruno, Bosch Annet, Brouwers Martijn, Dekker Hanka, Dobbelaere Dries, Engelen Marc, Groenendijk Marike C., Lachmann Robin, Langendonk Janneke G., Langeveld Mirjam, Linthorst Gabor, Morava Eva, Poll-The Bwee Tien, Rahman Shamima, Rubio-Gozalbo M. Estela, Spiekerkoetter Ute, Treacy Eileen, Wanders Ronald, Zschocke Johannes, Hagendijk Rob Position statement on the role of healthcare professionals, patient organizations and industry in European Reference Networks Orphanet journal of rare diseases 2016;11 (1):7 [PubMed]
  • Menke Leonie A., Engelen Marc, Alders Mariel, Odekerken Vincent J. J., Baas Frank, Cobben Jan M. Recurrent GNAO1 Mutations Associated With Developmental Delay and a Movement Disorder Journal of child neurology 2016;31 (14):1598-1601 [PubMed]
  • van der Land Veronica, Mutsaerts Henri J. M. M., Engelen Marc, Heijboer Harriët, Roest Mark, Hollestelle Martine J., Kuijpers Taco W., Nederkoorn Paul J., Cnossen Marjon H., Majoie Charles B. L. M., Nederveen Aart J., Fijnvandraat Karin Risk factor analysis of cerebral white matter hyperintensities in children with sickle cell disease British journal of haematology 2016;172 (2):274-284 [PubMed]
  • de Sain-van der Velden M. G. M., Jans J. J., Figee M., Engelen M., Prinsen H. C. M. T., Verhoeven-Duif N. M., van Kuilenburg A. B. P., Visser G., Vinkers C. H. Stofwisselingsziekten binnen de psychiatrie Tijdschrift voor psychiatrie 2016;58 (5):402-406 [PubMed]
  • van Geel Björn M., Engelen Marc, Kemp Stephan X-linked Adrenoleukodystrophyin: Carla E.M. Hollak, Robin Lachmann, editors. Inherited Metabolic Disease in Adults: A Clinical Guide. Oxford University Press; 2016. p. 387-393, ISBN 9780199972135
  • Berendse Kevin, Engelen Marc, Ferdinandusse Sacha, Majoie Charles B. L. M., Waterham Hans R., Vaz Frédéric M., Koelman Johannes H. T. M., Barth Peter G., Wanders Ronald J. A., Poll-The Bwee Tien Zellweger spectrum disorders: clinical manifestations in patients surviving into adulthood Journal of inherited metabolic disease 2016;39 (1):93-106 [PubMed]

2015

  • van Geel Björn M., Poll-The Bwee Tien, Verrips Aad, Boelens Jaap-Jan, Kemp Stephan, Engelen Marc Hematopoietic cell transplantation does not prevent myelopathy in X-linked adrenoleukodystrophy: a retrospective study Journal of inherited metabolic disease 2015;38 (2):359-361 [PubMed]
  • Velema Marieke, Boot Erik, Engelen Marc, Hollak Carla Parkinsonism in phenylketonuria: a consequence of dopamine depletion? JIMD reports 2015;20:35-38 [PubMed]
  • Engelen Marc, Barbier Mathieu, Dijkstra Inge M. E., Schür Remmelt, de Bie Rob M., Verhamme Camiel, Dijkgraaf Marcel G. W., Aubourg Patrick A., Wanders Ronald J. A., van Geel Bjorn M., de Visser Marianne, Poll-The Bwee T., Kemp Stephan Reply: Age-dependent penetrance among females with X-linked adrenoleukodystrophy Brain 2015;138 (2):e326 [PubMed]
  • van Schaik Sander M., Reneman Liesbeth, Engelen Marc, Roos Yvo B. W. E. M., Poll-The Bwee Tien Strokelike episodes and cutis marmorata telangiectatica congenita Journal of child neurology 2015;30 (1):129-132 [PubMed]
  • van der Land Veronica, Hijmans Channa T., de Ruiter Marieke, Mutsaerts Henri J. M. M., Cnossen Marjon H., Engelen Marc, Majoie Charles B. L. M., Nederveen Aart J., Grootenhuis Martha A., Fijnvandraat Karin Volume of white matter hyperintensities is an independent predictor of intelligence quotient and processing speed in children with sickle cell disease British journal of haematology 2015;168 (4):553-556 [PubMed]
  • Klouwer Femke C. C., Berendse Kevin, Ferdinandusse Sacha, Wanders Ronald J. A., Engelen Marc, Poll-The Bwee Tien Zellweger spectrum disorders: clinical overview and management approach Orphanet journal of rare diseases 2015;10:151 [PubMed]

2014

  • de Beer Marlijn, Engelen Marc, van Geel Björn M. Frequent occurrence of cerebral demyelination in adrenomyeloneuropathy Neurology 2014;83 (24):2227-2231 [PubMed]
  • Berendse Kevin, Engelen Marc, Linthorst Gabor E., van Trotsenburg A. S. Paul, Poll-The Bwee Tien High prevalence of primary adrenal insufficiency in Zellweger spectrum disorders Orphanet journal of rare diseases 2014;9:133 [PubMed]
  • Engelen Marc, Barbier Mathieu, Dijkstra Inge M. E., Schür Remmelt, de Bie Rob M. A., Verhamme Camiel, Dijkgraaf Marcel G. W., Aubourg Patrick A., Wanders Ronald J. A., van Geel Bjorn M., de Visser Marianne, Poll-The Bwee T., Kemp Stephan X-linked adrenoleukodystrophy in women: a cross-sectional cohort study Brain 2014;137 (Part 3):693-706 [PubMed]
  • Engelen Marc, Kemp Stephan, Poll-The Bwee-Tien X-linked adrenoleukodystrophy: pathogenesis and treatment Current neurology and neuroscience reports 2014;14 (10):486 [PubMed]

2013

  • Cobben J. M., Engelen M., Polstra A. Array CGH on unstimulated blood does not detect all cases of Pallister-Killian syndrome: buccal smear analysis should remain the diagnostic procedure of first choice American journal of medical genetics. Part A 2013;161AA (6):1517-1519 [PubMed]
  • Demirdas Serwet, van Kessel Imke N., Korndewal Marjolein J., Hollak Carla E. M., Meutgeert Hanka, Klaren Anja, van Rijn Margreet, van Spronsen Francjan J., Bosch Annet M., Asselbergs Folkert W., Blank Christiaan, Derks Terry G. J., Diekman Eugène F., Dijsselhof Monique E., Engelen Marc, van Hasselt Peter M., ter Horst Nienke M., van den Hurk Dorine A. M., Janssen Mirian C. H., Karstens Francois P. J., van der Louw Elles, Morava Eva, Nicolai Joost, van de Pol Ludo, Poll-The Bwee Tien, Rubio-Gozalbo Estela, Smit G. Peter A., de Ruijter Jessica, Timmer Corrie, Touw Catharina M. L., Visser Gepke, de Valk Harold W., Wijburg Frits A., Williams Monique Clinical pathways for inborn errors of metabolism: warranted and feasible Orphanet journal of rare diseases 2013;8 (1):37 [PubMed]
  • Engelen Marc, Ofman Rob, Dijkgraaf Marcel, van Geel Bjorn, de Visser Marianne, Wanders Ronald, Poll-The Bwee Tien, Kemp Stephan Comment on the paper "Effect of statin treatment on adrenomyeloneuropathy with cerebral inflammation: a revisit" Clinical neurology and neurosurgery 2013;115 (11):2401-2402 [PubMed]

2012

  • Gevers Sanna, Nederveen Aart J., Fijnvandraat Karin, van den Berg Sandra M., van Ooij Pim, Heijtel Dennis F., Heijboer Harriët, Nederkoorn Paul J., Engelen Marc, van Osch Matthias J., Majoie Charles B. Arterial spin labeling measurement of cerebral perfusion in children with sickle cell disease Journal of magnetic resonance imaging 2012;35 (4):779-787 [PubMed]
  • Engelen Marc, Tran Luc, Ofman Rob, Brennecke Josephine, Moser Ann B., Dijkstra Inge M. E., Wanders Ronald J. A., Poll-The Bwee Tien, Kemp Stephan Bezafibrate for X-Linked Adrenoleukodystrophy PLoS ONE 2012;7 (7):e41013 [PubMed]
  • Engelen Marc, Schackmann Martin J. A., Ofman Rob, Sanders Robert-Jan, Dijkstra Inge M. E., Houten Sander M., Fourcade Stéphane, Pujol Aurora, Poll-The Bwee Tien, Wanders Ronald J. A., Kemp Stephan Bezafibrate lowers very long-chain fatty acids in X-linked adrenoleukodystrophy fibroblasts by inhibiting fatty acid elongation Journal of inherited metabolic disease 2012;35 (6):1137-1145 [PubMed]
  • Poll-The Bwee Tien, Engelen Marc Peroxisomal Leukoencephalopathy Seminars in neurology 2012;32 (1):42-50 [PubMed]
  • Engelen Marc Translational studies in X-linked adrenoleukodystrophy 2012. 135p. ISBN 9789461914743. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Poll-The B. T., de Visser M.; Co-supervisors: Kemp S., van Geel B. M.)
  • Engelen Marc, Kemp Stephan, de Visser Marianne, van Geel Björn M., Wanders Ronald J. A., Aubourg Patrick, Poll-The Bwee Tien X-linked adrenoleukodystrophy (X-ALD): clinical presentation and guidelines for diagnosis, follow-up and management: Clinical presentation and guidelines for diagnosis, follow-up and management Orphanet journal of rare diseases 2012;7 (1) [PubMed]

2011

  • Engelen Marc, Westhoff Dunja, de Gans Jan, Nederkoorn Paul J. A 64-year old man presenting with carotid artery occlusion and corticobasal syndrome: a case report Journal of medical case reports 2011;5 (1):357 [PubMed]
  • Poll The Bwee Tien, Engelen Marc X-gebonden adrenoleucodystrofie (X-ALD)in: E. Carbasius-Weber, Merel van Veen, Gepke Visser, editors. Dieet bij Metabole Ziekten. Utrecht: WKZ/UMC Utrecht; 2011. p. 278-289, ISBN 9789081745703
  • Engelen Marc, van der Kooi Anneke J., Kemp Stephan, Wanders Ronald J. A., Sistermans Erik A., Waterham Hans R., Koelman Johannes T. M., van Geel Björn M., de Visser Marianne X-linked adrenomyeloneuropathy due to a novel missense mutation in the ABCD1 start codon presenting as demyelinating neuropathy Journal of the peripheral nervous system 2011;16 (4):353-355 [PubMed]

2010

  • Engelen Marc, Ofman Rob, Dijkgraaf Marcel G. W., Hijzen Michiel, van der Wardt Lucinda A., van Geel Bjorn M., de Visser Marianne, Wanders Ronald J. A., Poll-The Bwee Tien, Kemp Stephan Lovastatin in X-Linked Adrenoleukodystrophy New England journal of medicine 2010;362 (3):276-277 [PubMed]

2009

  • Engelen Marc, Nederkoorn Paul J., Smits Marion, van de Beek Diederik Delayed life-threatening subdural hematoma after minor head injury in a patient with severe coagulopathy: a case report Cases journal 2009;2:7587 [PubMed]

2008

  • Engelen M., Ofman R., Mooijer P. A. W., Poll-The B. T., Wanders R. J. A., Kemp S. Cholesterol-deprivation increases mono-unsaturated very long-chain fatty acids in skin fibroblasts from patients with X-linked adrenoleukodystrophy BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 2008;1781 (3):105-111 [PubMed]
  • Engelen M., Kemp S., van Geel B. M. Van gen naar ziekte; X-gebonden adrenoleukodystrofie Nederlands tijdschrift voor geneeskunde 2008;152 (14):804-808 [PubMed]

2005

  • de Jong Brigit A., Engelen Marc, van Schaik Ivo N., Vermeulen Marinus Confusing Cochrane reviews on treatment in multiple sclerosis Lancet neurology 2005;4 (6):330-331 [PubMed]
  • Engelen Marc, Tijssen Marina A. J. Paroxysmal non-kinesigenic dyskinesia in antiphospholipid syndrome Movement disorders 2005;20 (1):111-113 [PubMed]

2002

  • Boekholdt S. Matthijs, Trip Mieke D., Peters Ron J. G., Engelen Marc, Boer Jolanda M. A., Feskens Edith J. M., Zwinderman Aeilko H., Kastelein John J. P., Reitsma Pieter H. Thrombospondin-2 polymorphism is associated with a reduced risk of premature myocardial infarction Arteriosclerosis, thrombosis, and vascular biology 2002;22 (12):E24-E27 [PubMed]

2001

  • Docherty C. C., Kalmar-Nagy J., Engelen M., Nathanielsz P. W. Development of fetal vascular responses to endothelin-1 and acetylcholine in the sheep American journal of physiology. Regulatory, integrative and comparative physiology 2001;280 (2):R554-R562 [PubMed]
  • Docherty C. C., Kalmar-Nagy J., Engelen M., Koenen S. V., Nijland M., Kuc R. E., Davenport A. P., Nathanielsz P. W. Effect of in vivo fetal infusion of dexamethasone at 0.75 GA on fetal ovine resistance artery responses to ET-1 American journal of physiology. Regulatory, integrative and comparative physiology 2001;281 (1):R261-R268 [PubMed]