M. Spaargaren PhD publications

2021

• Ren Zemin, Lantermans Hildo, Kuil Annemieke, Kraan Willem, Arenzana-Seisdedos Fernando, Kersten Marie José, Spaargaren Marcel, Pals Steven T. The CXCL12gamma chemokine immobilized by heparan sulfate on stromal niche cells controls adhesion and mediates drug resistance in multiple myeloma JOURNAL OF HEMATOLOGY & ONCOLOGY 2021;14 (1) [PubMed]

2020

• Joosten Sander P. J., Spaargaren Marcel, Clevers Hans, Pals Steven T. Hepatocyte growth factor/MET and CD44 in colorectal cancer: partners in tumorigenesis and therapy resistance BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER 2020;1874 (2) [PubMed]
• Lantermans Hildo C., Minderman Marthe, Kuil Annemieke, Kersten Marie-José, Pals Steven T., Spaargaren Marcel Identification of the SRC-family tyrosine kinase HCK as a therapeutic target in mantle cell lymphoma Leukemia 2020 [PubMed]
• Vermaat Joost S., Somers Sebastiaan F., de Wreede Liesbeth C., Kraan Willem, de Groen Ruben A. L., Schrader Anne M. R., Kerver Emile D., Scheepstra Cornelis G., Berenschot Henriëtte, Deenik Wendy, Wegman Jurgen, Broers Rianne, de Boer Jan-Paul D., Nijland Marcel, van Wezel Tom, Veelken Hendrik, Spaargaren Marcel, Cleven Arjen H., Kersten Marie José, Pals Steven T. MYD88 mutations identify a molecular subgroup of diffuse large B-cell lymphoma with an unfavorable prognosis Haematologica 2020;105 (2):424-434 [PubMed]

2019

• van Andel Harmen, Kocemba Kinga A., Spaargaren Marcel, Pals Steven T. Aberrant Wnt signaling in multiple myeloma: molecular mechanisms and targeting options Leukemia 2019;33 (5):1063-1075 [PubMed]
• Ren Zemin Heparan sulfate proteoglycans: key moderators of the interaction of multiple myeloma with the bone marrow niche 2019. 154p. ISBN 9789463752404. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Pals S. T.; Co-supervisor: Spaargaren M.)
• Joosten Sander P. J., Mizutani Tomohiro, Spaargaren Marcel, Clevers Hans, Pals Steven T. MET Signaling Overcomes Epidermal Growth Factor Receptor Inhibition in Normal and Colorectal Cancer Stem Cells Causing Drug Resistance Gastroenterology 2019;157 (4):1153-1155.e1 [PubMed]
• Maes Anke, Maes Ken, de Raeve Hendrik, de Smedt Eva, Vlummens Philip, Szablewski Vanessa, Devin Julie, Faict Sylvia, de Veirman Kim, Menu Eline, Offner Fritz, Spaargaren Marcel, Moreaux J. rôme, Vanderkerken Karin, van Valckenborgh Els, de Bruyne Elke The anaphase-promoting complex/cyclosome: a new promising target in diffuse large B-cell lymphoma and mantle cell lymphoma British journal of cancer 2019;120 (12):1137-1146 [PubMed]
• van Andel Harmen Wnt signaling in the pathogenesis of multiple myeloma 2019. 298p. ISBN 9789463753869. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Pals S. T.; Co-supervisor: Spaargaren M.)

2018

• Ren Zemin, van Andel Harmen, de Lau Wim, Hartholt Robin B., Maurice Madelon M., Clevers Hans, Kersten Marie José, Spaargaren Marcel, Pals Steven T. Syndecan-1 promotes Wnt/β-catenin signaling in multiple myeloma by presenting Wnts and R-spondins Blood 2018;131 (9):982-944 [PubMed]

2017

• van Andel Harmen, Ren Zemin, Koopmans Iris, Joosten Sander P. J., Kocemba Kinga A., de Lau Wim, Kersten Marie José, de Bruin Alexander M., Guikema Jeroen E. J., Clevers Hans, Spaargaren Marcel, Pals Steven T. Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins Proceedings of the National Academy of Sciences of the United States of America 2017;114 (2):376-381 [PubMed]
• Singh Simar Pal, Pillai Saravanan Y., de Bruijn Marjolein J. W., Stadhouders Ralph, Corneth Odilia B. J., van den Ham Henk Jan, Muggen Alice, van Ijcken Wilfred, Slinger Erik, Kuil Annemieke, Spaargaren Marcel, Kater Arnon P., Langerak Anton W., Hendriks Rudi W. Cell lines generated from a chronic lymphocytic leukemia mouse model exhibit constitutive Btk and Akt signaling Oncotarget 2017;8 (42):71981-71995 [PubMed]
• van Andel H., Kocemba K. A., de Haan-Kramer A., Mellink C. H., Piwowar M., Broijl A., van Duin M., Sonneveld P., Maurice M. M., Kersten M. J., Spaargaren M., Pals S. T. Loss of CYLD expression unleashes Wnt signaling in multiple myeloma and is associated with aggressive disease Oncogene 2017;36 (15):2105-2115 [PubMed]
• Joosten Sander P. J., Zeilstra Jurrit, van Andel Harmen, Mijnals R. Clinton, Zaunbrecher Joost, Duivenvoorden Annet A. M., van de Wetering Marc, Clevers Hans, Spaargaren Marcel, Pals Steven T. MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms Gastroenterology 2017;153 (4):1040-+ [PubMed]
• de Rooij Martin F. M. Targeting the BCR signalosome in B cell malignancies 2017. 209p. ISBN 9789462997462. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Pals S. T.; Co-supervisor: Spaargaren M.)
• van Keimpema Martine, Grüneberg Leonie J., Schilder-Tol Esther J. M., Oud Monique E. C. M., Beuling Esther, Hensbergen Paul J., de Jong Johann, Pals Steven T., Spaargaren Marcel The small FOXP1 isoform predominantly expressed in activated B cell-like diffuse large B-cell lymphoma and full-length FOXP1 exert similar oncogenic and transcriptional activity in human B cells Haematologica 2017;102 (3):573-583 [PubMed]

2016

• de Rooij Martin F. M., Kuil Annemieke, Kraan Willem, Kersten Marie José, Treon Steven P., Pals Steven T., Spaargaren Marcel Ibrutinib and idelalisib target B cell receptor- but not CXCL12/CXCR4-controlled integrin-mediated adhesion in Waldenström macroglobulinemia Haematologica 2016;101 (3):e111-e115 [PubMed]
• Pals Steven T., Kersten Marie José, Spaargaren Marcel Targeting cell adhesion and homing as strategy to cure Waldenström's macroglobulinemia Best practice & research. Clinical haematology 2016;29 (2):161-168 [PubMed]
• Thijssen R., ter Burg J., van Bochove G. G. W., de Rooij M. F. M., Kuil A., Jansen M. H., Kuijpers T. W., Baars J. W., Virone-Oddos A., Spaargaren M., Egile C., van Oers M. H. J., Eldering E., Kersten M. J., Kater A. P. The pan phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor SAR245409 (voxtalisib/XL765) blocks survival, adhesion and proliferation of primary chronic lymphocytic leukemia cells Leukemia 2016;30 (2):337-345 [PubMed]
• Thijssen R., ter Burg J., van Bochove G. G. W., de Rooij M. F. M., Kuil A., Jansen M. H., Kuijpers T. W., Baars J. W., Virone-Oddos A., Spaargaren M., Egile C., van Oers M. H. J., Eldering E., Kersten M. J., Kater A. P. The pan phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor SAR245409 ( voxtalisib/XL765) blocks survival, adhesion and proliferation of primary chronic lymphocytic leukemia cells (Vol 30, pg 337, 2016) Leukemia 2016;30 (9):1963 [PubMed]

2015

• Spaargaren M., de Rooij M. F. M., Kater A. P., Eldering E. BTK inhibitors in chronic lymphocytic leukemia: a glimpse to the future Oncogene 2015;34 (19):2426-2436 [PubMed]
• de Rooij Martin F. M., Kuil Annemieke, Kater Arnon P., Kersten Marie José, Pals Steven T., Spaargaren Marcel Ibrutinib and idelalisib synergistically target BCR-controlled adhesion in MCL and CLL: a rationale for combination therapy Blood 2015;125 (14):2306-2309 [PubMed]
• Spaargaren Marcel Ibrutinib for AML? Check CD117 (KIT)! Lancet. Haematology 2015;2 (5):e180-e181 [PubMed]
• van Keimpema Martine, Grüneberg Leonie J., Mokry Michal, van Boxtel Ruben, van Zelm Menno C., Coffer Paul, Pals Steven T., Spaargaren Marcel The forkhead transcription factor FOXP1 represses human plasma cell differentiation Blood 2015;126 (18):2098-2109 [PubMed]
• van Keimpema Martine The FOX and the mutants in mature human B cells and DLBCL: The role of FOXP1 in mature human B cell biology and lymphomagenesis & prevalence of oncogenic MyD88 and CD79B mutations in diffuse large B cell lymphoma 2015. 213p. ISBN 9789462991866. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Pals S. T.; Co-supervisor: Spaargaren M.)

2014

• Kersten M. J., Kraan W., Doorduijn J., Bromberg J., Lam K., Kluin P. M., van der Holt B. J., Spaargaren M., Pals S. T. Diffuse large B cell lymphomas relapsing in the CNS lack oncogenic MYD88 and CD79B mutations Blood cancer journal 2014;4:e266 [PubMed]
• van Keimpema Martine, Grüneberg Leonie J., Mokry Michal, van Boxtel Ruben, Koster Jan, Coffer Paul J., Pals Steven T., Spaargaren Marcel FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cells Blood 2014;124 (23):3431-3440 [PubMed]
• Kraan W., van Keimpema M., Horlings H. M., Schilder-Tol E. J. M., Oud M. E. C. M., Noorduyn L. A., Kluin P. M., Kersten M. J., Spaargaren M., Pals S. T. High prevalence of oncogenic MYD88 and CD79B mutations in primary testicular diffuse large B-cell lymphoma Leukemia 2014;28 (3):719-720 [PubMed]
• Zeilstra J., Joosten S. P. J., van Andel H., Tolg C., Berns A., Snoek M., van de Wetering M., Spaargaren M., Clevers H., Pals S. T. Stem cell CD44v isoforms promote intestinal cancer formation in Apc(min) mice downstream of Wnt signaling Oncogene 2014;33 (5):665-670 [PubMed]
• Kocemba Kinga A. The bone marrow niche in the pathogenesis of multiple myeloma: A role for Wnt signaling and adrenomedullin 2014. 223p. ISBN 9788363861162. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Pals S. T.; Co-supervisor: Spaargaren M.)

2013

• Zeilstra Jurrit, Joosten Sander P. J., Vermeulen Louis, Koster Jan, Medema Jan Paul, Versteeg Rogier, Spaargaren Marcel, Pals Steven T. CD44 expression in intestinal epithelium and colorectal cancer is independent of p53 status PLoS ONE 2013;8 (8):e72849 [PubMed]
• Chang Betty Y., Francesco Michelle, de Rooij Martin F. M., Magadala Padmaja, Steggerda Susanne M., Huang Min Mei, Kuil Annemieke, Herman Sarah E. M., Chang Stella, Pals Steven T., Wilson Wyndham, Wiestner Adrian, Spaargaren Marcel, Buggy Joseph J., Elias Laurence Egress of CD19(+)CD5(+) cells into peripheral blood following treatment with the Bruton tyrosine kinase inhibitor ibrutinib in mantle cell lymphoma patients Blood 2013;122 (14):2412-2424 [PubMed]
• Reijmers Rogier M., Spaargaren Marcel, Pals Steven T. Heparan sulfate proteoglycans in the control of B cell development and the pathogenesis of multiple myeloma FEBS journal 2013;280 (10):2180-2193 [PubMed]
• Kraan W., Horlings H. M., van Keimpema M., Schilder-Tol E. J. M., Oud M. E. C. M., Scheepstra C., Kluin P. M., Kersten M. J., Spaargaren M., Pals S. T. High prevalence of oncogenic MYD88 and CD79B mutations in diffuse large B-cell lymphomas presenting at immune-privileged sites Blood cancer journal 2013;3:e139 [PubMed]
• Kocemba K. A., van Andel H., de Haan-Kramer A., Mahtouk K., Versteeg R., Kersten M. J., Spaargaren M., Pals S. T. The hypoxia target adrenomedullin is aberrantly expressed in multiple myeloma and promotes angiogenesis Leukemia 2013;27 (8):1729-1737 [PubMed]

2012

• Langerak A. W., Groenen P. J. T. A., Brüggemann M., Beldjord K., Bellan C., Bonello L., Boone E., Carter G. I., Catherwood M., Davi F., Delfau-Larue M.-H., Diss T., Evans P. A. S., Gameiro P., Garcia Sanz R., Gonzalez D., Grand D., Håkansson A., Hummel M., Liu H., Lombardia L., Macintyre E. A., Milner B. J., Montes-Moreno S., Schuuring E., Spaargaren M., Hodges E., van Dongen J. J. M. EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations Leukemia 2012;26 (10):2159-2171 [PubMed]
• de Rooij Martin F. M., Kuil Annemieke, Geest Christian R., Eldering Eric, Chang Betty Y., Buggy Joseph J., Pals Steven T., Spaargaren Marcel The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia Blood 2012;119 (11):2590-2594 [PubMed]
• Kocemba Kinga A., Groen Richard W. J., van Andel Harmen, Kersten Marie José, Mahtouk Karène, Spaargaren Marcel, Pals Steven T. Transcriptional Silencing of the Wnt-Antagonist DKK1 by Promoter Methylation Is Associated with Enhanced Wnt Signaling in Advanced Multiple Myeloma PLoS ONE 2012;7 (2):e30359 [PubMed]
• Celie Johanna W. A. M., Katta Kiran K., Adepu Saritha, Melenhorst Wynand B. W. H., Reijmers Rogier M., Slot Edith M., Beelen Robert H. J., Spaargaren Marcel, Ploeg Rutger J., Navis Gerjan, Homan van der Heide J. J., van Dijk Marcory C. R. F., van Goor Harry, van den Born Jacob Tubular epithelial syndecan-1 maintains renal function in murine ischemia/reperfusion and human transplantation Kidney international 2012;81 (7):651-661 [PubMed]

2011

• Reijmers Rogier M., Groen Richard W. J., Kuil Annemieke, Weijer Kees, Kimberley Fiona C., Medema Jan Paul, van Kuppevelt Toin H., Li Jin-Ping, Spaargaren Marcel, Pals Steven T. Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival Blood 2011;117 (23):6162-6171 [PubMed]
• Spaargaren Marcel Lymphoma spread? Target CD47-SIRPα! Blood 2011;118 (18):4762-4764 [PubMed]
• Groen Richard W. J., de Rooij Martin F. M., Kocemba Kinga A., Reijmers Rogier M., de Haan-Kramer Anneke, Overdijk Marije B., Aalders Linda, Rozemuller Henk, Martens Anton C. M., Bergsagel P. Leif, Kersten Marie José, Pals Steven T., Spaargaren Marcel N-cadherin-mediated interaction with multiple myeloma cells inhibits osteoblast differentiation Haematologica 2011;96 (11):1653-1661 [PubMed]
• Zeilstra Jurrit, Joosten Sander P. J., Wensveen Felix M., Dessing Mark C., Schütze Denise M., Eldering Eric, Spaargaren Marcel, Pals Steven T. WNT signaling controls expression of pro-apoptotic BOK and BAX in intestinal cancer Biochemical and biophysical research communications 2011;406 (1):1-6 [PubMed]

2010

• Reijmers Rogier M. Heparan sulfate proteoglycans in B cell maturation and myeloma plasma cell survival 2010. 165p. ISBN 9789090256450. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Pals S. T.; Co-supervisor: Spaargaren M.)
• Reijmers Rogier M., Vondenhoff Mark F. R., Roozendaal Ramon, Kuil Annemieke, Li Jin-Ping, Spaargaren Marcel, Pals Steven T., Mebius Reina E. Impaired Lymphoid Organ Development in Mice Lacking the Heparan Sulfate Modifying Enzyme Glucuronyl C5-Epimerase Journal of immunology (Baltimore, Md. 2010;184 (7):3656-3664 [PubMed]
• Groen Richard W. J. Microenvironmental regulation of multiple myeloma and malignant lymphoma. The role of HGF, Wnts, heparan sulfate proteoglycans, and N-cadherin 2010. 199p. ISBN 9789090257686. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Pals S. T.; Co-supervisor: Spaargaren M.)
• Reijmers Rogier M., Groen Richard W. J., Rozemuller Henk, Kuil Annemieke, de Haan-Kramer Anneke, Csikós Tamás, Martens Anton C. M., Spaargaren Marcel, Pals Steven T. Targeting EXT1 reveals a crucial role for heparan sulfate in the growth of multiple myeloma Blood 2010;115 (3):601-604 [PubMed]
• Mahtouk Karène, Tjin Esther P. M., Spaargaren Marcel, Pals Steven T. The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER 2010;1806 (2):208-219 [PubMed]

2008

• Zeilstra Jurrit, Joosten Sander P. J., Dokter Maarten, Verwiel Eugène, Spaargaren Marcel, Pals Steven T. Deletion of the WNT target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis Cancer research 2008;68 (10):3655-3661 [PubMed]
• Groen Richard W. J., Oud Monique E. C. M., Schilder-Tol Esther J. M., Overdijk Marije B., ten Berge Derk, Nusse Roel, Spaargaren Marcel, Pals Steven T. Illegitimate WNT pathway activation by beta-catenin mutation or autocrine stimulation in T-cell malignancies Cancer research 2008;68 (17):6969-6977 [PubMed]
• Csikós Tamás, Reijmers Rogier M., Uren Anthony G., Spaargaren Marcel, Pals Steven T. Instant conditional transgenesis in the mouse hematopoietic compartment Journal of immunological methods 2008;339 (2):259-263 [PubMed]
• de Gorter David J. J. Signaling pathways involved in B cell differentiation and disease. The role of Ral, Btk and Met 2008. 160p. ISBN 9789090228907. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Pals Steven T.; Co-supervisor: Spaargaren M.)
• de Gorter David J. J., Reijmers Rogier M., Beuling Esther A., Naber Hildegonda P. H., Kuil Annemieke, Kersten Marie José, Pals Steven T., Spaargaren Marcel The small GTPase Ral mediates SDF-1-induced migration of B cells and multiple myeloma cells Blood 2008;111 (7):3364-3372 [PubMed]
• Celie J. W. A. M., Reijmers R. M., Slot E. M., Beelen R. H. J., Spaargaren M., ter Wee P. M., Florquin S., van den Born J. Tubulointerstitial heparan sulfate proteoglycan changes in human renal diseases correlate with leukocyte influx and proteinuria American journal of physiology. Renal physiology 2008;294 (1):F253-F263 [PubMed]

2007

• de Gorter David J. J., Beuling Esther A., Kersseboom Rogier, Middendorp Sabine, van Gils Janine M., Hendriks Rudolf W., Pals Steven T., Spaargaren Marcel Bruton's tyrosine kinase and phospholipase C gamma 2 mediate chemokine-controlled B cell migration and homing Immunity 2007;26 (1):93-104 [PubMed]
• Pals Steven T., de Gorter David J. J., Spaargaren Marcel Lymphoma dissemination: the other face of lymphocyte homing Blood 2007;110 (9):3102-3111 [PubMed]
• Brüggemann M., White H., Gaulard P., Garcia-Sanz R., Gameiro P., Oeschger S., Jasani B., Ott M., Delsol G., Orfao A., Tiemann M., Herbst H., Langerak A. W., Spaargaren M., Moreau E., Groenen P. J. T. A., Sambade C., Foroni L., Carter G. I., Hummel M., Bastard C., Davi F., Delfau-Larue M.-H., Kneba M., van Dongen J. J. M., Beldjord K., Molina T. J. Powerful strategy for polymerase chain reaction-based clonality assessment in T-cell malignancies Report of the BIOMED-2 Concerted Action BHM4 CT98-3936 Leukemia 2007;21 (2):215-221 [PubMed]
• Evans P. A. S., Pott Ch, Groenen P. J. T. A., Salles G., Davi F., Berger F., Garcia J. F., van Krieken J. H. J. M., Pals S., Kluin Ph, Schuuring E., Spaargaren M., Boone E., González D., Martinez B., Villuendas R., Gameiro P., Diss T. C., Mills K., Morgan G. J., Carter G. I., Milner B. J., Pearson D., Hummel M., Jung W., Ott M., Canioni D., Beldjord K., Bastard C., Delfau-Larue M. H., van Dongen J. J. M., Molina T. J., Cabeçadas J. Significantly improved PCR-based clonality testing in B-cell malignancies by use of multiple immunoglobulin gene targets. Report of the BIOMED-2 Concerted Action BHM4-CT98-3936 Leukemia 2007;21 (2):207-214 [PubMed]
• de Gorter David J. J., Vos Johanna C. M., Pals Steven T., Spaargaren Marcel The B cell antigen receptor controls AP-1 and NFAT activity through Ras-mediated activation of Ral Journal of immunology (Baltimore, Md. 2007;178 (3):1405-1414 [PubMed]

2006

• Tjin Esther P. M., Groen Richard W. J., Vogelzang Irma, Derksen Patrick W. B., Klok Melanie D., Meijer Helen P., van Eeden Susanne, Pals Steven T., Spaargaren Marcel Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma Blood 2006;107 (2):760-768 [PubMed]
• Schmidlin Heike, Dontje Wendy, Groot Fedde, Ligthart Suzanne J., Colantonio Arnaud D., Oud Monique E., Schilder-Tol Esther J., Spaargaren Marcel, Spits Hergen, Uittenbogaart Christel H., Blom Bianca Stimulated plasmacytoid dendritic cells impair human T-cell development Blood 2006;108 (12):3792-3800 [PubMed]

2005

• Tjin Esther P. M., Bende Richard J., Derksen Patrick W. B., van Huijstee Anne-Pauline, Kataoka Hiroaki, Spaargaren Marcel, Pals Steven T. Follicular dendritic cells catalyze hepatocyte growth factor (HGF) activation in the germinal center microenvironment by secreting the serine protease HGF activator Journal of immunology (Baltimore, Md. 2005;175 (5):2807-2813 [PubMed]
• Hendriks J., Planelles L., de Jong-Odding J., Hardenberg G., Pals S. T., Hahne M., Spaargaren M., Medema J. P. Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation Cell death and differentiation 2005;12 (6):637-648 [PubMed]
• Tjin E. P. M. The HFG/MET and WNT signaling pathways in B cell differentiation and neoplasia 2005. 123p. ISBN 9789090198965. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Pals S. T.; Co-supervisor: Spaargaren M.)

2004

• Derksen Patrick W. B., Tjin Esther, Meijer Helen P., Klok Melanie D., MacGillavry Harold D., van Oers Marinus H. J., Lokhorst Henk M., Bloem Andries C., Clevers Hans, Nusse Roel, van der Neut Ronald, Spaargaren Marcel, Pals Steven T. Illegitimate WNT signaling promotes proliferation of multiple myeloma cells Proceedings of the National Academy of Sciences of the United States of America 2004;101 (16):6122-6127 [PubMed]
• Tjin Esther P. M., Derksen Patrick W. B., Kataoka Hiroaki, Spaargaren Marcel, Pals Steven T. Multiple myeloma cells catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF-activator Blood 2004;104 (7):2172-2175 [PubMed]

2003

• van Dongen J. J. M., Langerak A. W., Brüggemann M., Evans P. A. S., Hummel M., Lavender F. L., Delabesse E., Davi F., Schuuring E., García-Sanz R., van Krieken J. H. J. M., Droese J., González D., Bastard C., White H. E., Spaargaren M., González M., Parreira A., Smith J. L., Morgan G. J., Kneba M., Macintyre E. A. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: Report of the BIOMED-2 Concerted Action BMH4-CT98-3936 Leukemia 2003;17 (12):2257-2317 [PubMed]
• Bende Richard J., Smit Laura A., Bossenbroek Janneke G., Aarts Wilhelmina M., Spaargaren Marcel, de Leval Laurence, Boeckxstaens Guy E. E., Pals Steven T., van Noesel Carel J. M. Primary follicular lymphoma of the small intestine: alpha4beta7 expression and immunoglobulin configuration suggest an origin from local antigen-experienced B cells American journal of pathology 2003;162 (1):105-113 [PubMed]
• Koopman Werner J. H., Bosch Remko R., van Emst-de Vries Sjenet E., Spaargaren Marcel, de Pont Jan Joep H. H. M., Willems Peter H. G. M. R-Ras alters Ca2+ homeostasis by increasing the Ca2+ leak across the endoplasmic reticular membrane Journal of biological chemistry 2003;278 (16):13672-13679 [PubMed]
• Spaargaren Marcel, Beuling Esther A., Rurup Mette L., Meijer Helen P., Klok Melanie D., Middendorp Sabine, Hendriks Rudolf W., Pals Steven T. The B cell antigen receptor controls integrin activity through Btk and PLCgamma2 Journal of experimental medicine 2003;198 (10):1539-1550 [PubMed]
• Derksen P. W. B., de Gorter D. J. J., Meijer H. P., Bende R. J., van Dijk M., Lokhorst H. M., Bloem A. C., Spaargaren M., Pals S. T. The hepatocyte growth factor/Met pathway controls proliferation and apoptosis in multiple myeloma Leukemia 2003;17 (4):764-774 [PubMed]

2002

• Taher Taher E. I., Tjin Esther P. M., Beuling Esther A., Borst Jannie, Spaargaren Marcel, Pals Steven T. c-Cbl is involved in met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination Journal of immunology (Baltimore, Md. 2002;169 (7):3793-3800 [PubMed]
• Derksen Patrick W. B., Keehnen Robert M. J., Evers Ludo M., van Oers Marinus H. J., Spaargaren Marcel, Pals Steven T. Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma Blood 2002;99 (4):1405-1410 [PubMed]
• Taher Taher E. I., Derksen Patrick W. B., de Boer Onno J., Spaargaren Marcel, Teeling Peter, van der Wal Allard C., Pals Steven T. Hepatocyte growth factor triggers signaling cascades mediating vascular smooth muscle cell migration Biochemical and biophysical research communications 2002;298 (1):80-86 [PubMed]
• Leeksma Onno C., van Achterberg Tanja A. E., Tsumura Yoshikazu, Toshima Jiro, Eldering Eric, Kroes Wilma G. M., Mellink Clemens, Spaargaren Marcel, Mizuno Kensaku, Pannekoek Hans, de Vries Carlie J. M. Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1 European Journal of Biochemistry / FEBS 2002;269 (10):2546-2556 [PubMed]

2000

• Wielenga V. J., van der Voort R., Taher T. E., Smit L., Beuling E. A., van Krimpen C., Spaargaren M., Pals S. T. Expression of c-Met and heparan-sulfate proteoglycan forms of CD44 in colorectal cancer American journal of pathology 2000;157 (5):1563-1573 [PubMed]
• Versteeg H. H., Hoedemaeker I., Diks S. H., Stam J. C., Spaargaren M., van Bergen En Henegouwen P. M., van Deventer S. J., Peppelenbosch M. P. Factor VIIa/tissue factor-induced signaling via activation of Src-like kinases, phosphatidylinositol 3-kinase, and Rac Journal of biological chemistry 2000;275 (37):28750-28756 [PubMed]
• van der Voort R., Keehnen R. M., Beuling E. A., Spaargaren M., Pals S. T. Regulation of cytokine signaling by B cell antigen receptor and CD40-controlled expression of heparan sulfate proteoglycans Journal of experimental medicine 2000;192 (8):1115-1124 [PubMed]
• van der Voort R., Taher T. E., Derksen P. W., Spaargaren M., van der Neut R., Pals S. T. The hepatocyte growth factor/Met pathway in development, tumorigenesis, and B-cell differentiation Advances in cancer research 2000;79:39-90 [PubMed]

1999

• Geijsen N., Spaargaren M., Raaijmakers J. A., Lammers J. W., Koenderman L., Coffer P. J. Association of RACK1 and PKCbeta with the common beta-chain of the IL-5/IL-3/GM-CSF receptor Oncogene 1999;18 (36):5126-5130 [PubMed]
• Taher T. E., van der Voort R., Smit L., Keehnen R. M., Schilder-Tol E. J., Spaargaren M., Pals S. T. Cross-talk between CD44 and c-Met in B cells Current topics in microbiology and immunology 1999;246:31-7; discussion 38 [PubMed]
• van der Voort R., Taher T. E., Wielenga V. J., Spaargaren M., Prevo R., Smit L., David G., Hartmann G., Gherardi E., Pals S. T. Heparan sulfate-modified CD44 promotes hepatocyte growth factor/scatter factor-induced signal transduction through the receptor tyrosine kinase c-Met Journal of biological chemistry 1999;274 (10):6499-6506 [PubMed]
• Spaargaren M., Bos J. L. Rab5 induces Rac-independent lamellipodia formation and cell migration Molecular biology of the cell 1999;10 (10):3239-3250 [PubMed]

1996

• Herrmann C., Horn G., Spaargaren M., Wittinghofer A. Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor Journal of biological chemistry 1996;271 (12):6794-6800 [PubMed]
• Wolthuis R. M., Bauer B., van 't Veer L. J., de Vries-Smits A. M., Cool R. H., Spaargaren M., Wittinghofer A., Burgering B. M., Bos J. L. RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein Oncogene 1996;13 (2):353-362 [PubMed]

1995

• Schalkwijk C. G., Spaargaren M., Defize L. H., Verkleij A. J., van den Bosch H., Boonstra J. Epidermal growth factor (EGF) induces serine phosphorylation-dependent activation and calcium-dependent translocation of the cytosolic phospholipase A2 European Journal of Biochemistry / FEBS 1995;231 (3):593-601 [PubMed]
• Spaargaren M., Bischoff J. R., McCormick F. Signal transduction by Ras-like GTPases: a potential target for anticancer drugs Gene expression 1995;4 (6):345-356 [PubMed]

1994

• Spaargaren M., Bischoff J. R. Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap Proceedings of the National Academy of Sciences of the United States of America 1994;91 (26):12609-12613 [PubMed]
• Spaargaren M., Martin G. A., McCormick F., Fernandez-Sarabia M. J., Bischoff J. R. The Ras-related protein R-ras interacts directly with Raf-1 in a GTP-dependent manner Biochemical journal 1994;300 ( Pt 2):303-307 [PubMed]

1992

• Spaargaren M., Wissink S., Defize L. H., de Laat S. W., Boonstra J. Characterization and identification of an epidermal-growth-factor-activated phospholipase A2 Biochemical journal 1992;287 ( Pt 1):37-43 [PubMed]

1991

• Spaargaren M., Defize L. H., Boonstra J., de Laat S. W. Antibody-induced dimerization activates the epidermal growth factor receptor tyrosine kinase Journal of biological chemistry 1991;266 (3):1733-1739 [PubMed]

1990

• Spaargaren M., Defize L. H., de Laat S. W., Boonstra J. Antibody-induced activation of the epidermal growth factor receptor tyrosine kinase requires the presence of detergent Biochemical and biophysical research communications 1990;171 (2):882-889 [PubMed]
• van Belzen N., Spaargaren M., Verkleij A. J., Boonstra J. Interaction of epidermal growth factor receptors with the cytoskeleton is related to receptor clustering Journal of cellular physiology 1990;145 (2):365-375 [PubMed]