M.B.M. Teunissen PhD publications

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Publications PhD M.B.M. Teunissen

Position
Assistant Professor
Main activities
Education, Research
Specialisation
Immunology, Dermatology
Focus of research
A properly functioning skin immune system is essential to protect this large organ from pathogen entry and tumor cell outgrowth. Many skin diseases are characterized by dysregulation of the immune response. My goal is to understand the mechanisms of the innate and adaptive immune responses in the skin in order to explain the immunopathology of inflammatory skin disorders, such as psoriasis. To this aim both clinical and basic research is performed, using skin specimens from patients and healthy volunteers.

One of the research lines focuses on cutaneous dendritic cells: epidermal Langerhans cells and dermal dendritic cell subsets. These cells are isolated from human skin specimens or generated from monocytes using special cocktails of cytokines. Dendritic cells activate T cells and regulate their effector-function via a complex array of co-stimulatory and polarizing signals. These signals expressed by dendritic cells are quite flexible and dependent on micro-environmental circumstances. The aim is to determine the phenotypical and functional characteristics of these dendritic cell subsets and to understand how these properties can manipulated. With this knowledge it may be possible to render dendritic cells suitable as vaccine-based adjuvants, for instance to establish or break tolerance.

Another line of research focuses on the pathogenesis of psoriasis and encompasses the determination of the number, distribution, and state of activation of different cell types, as well as the presence of inflammatory mediators in lesional skin. In addition, cells (e.g. T cells, dendritic cells) are isolated from psoriatic lesional skin to study their function in order to determine abbarations as compared to their counterparts in healthy skin. Better understanding of the inflammatory processes involved in the development of psoriasis may lead to the identification of new drug targets to treat this disease.

2020

  • Bernink Jochem H., Ohne Yoichiro, Teunissen Marcel B. M., Wang Jingya, Wu Jincheng, Krabbendam Lisette, Guntermann Christine, Volckmann Richard, Koster Jan, van Tol Sophie, Ramirez Ivan, Shrestha Yashaswi, de Rie Menno A., Spits Hergen, Ros Xavier Romero, Humbles Alison A. Author Correction: c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies (Nature Immunology, (2019), 20, 8, (992-1003), 10.1038/s41590-019-0423-0) Nature immunology 2020;21 (1):101 [PubMed]
  • Dijkgraaf Feline E., Matos Tiago R., Hoogenboezem Mark, Toebes Mireille, Vredevoogd David W., Mertz Marjolijn, van den Broek Bram, Song Ji-Ying, Teunissen Marcel B. M., Luiten Rosalie M., Beltman Joost B., Schumacher Ton N. Author Correction: Tissue patrol by resident memory CD8+ T cells in human skin (Nature Immunology, (2019), 20, 6, (756-764), 10.1038/s41590-019-0404-3) Nature immunology 2020;21 (6):696 [PubMed]
  • de Boer Onno J., Krebbers Gabrielle, Mackaaij Claire, Florquin Sandrine, de Rie Menno A., van der Wal Allard C., Teunissen Marcel B. M. Authors’ Response to Letter to the Editor on “Unidentified Variables May Account for Variability in Multiplexing Results” journal of histochemistry and cytochemistry 2020;68 (5):355-356 [PubMed]
  • de Boer Onno J., Krebbers Gabrielle, Mackaaij Claire, Florquin Sandrine, de Rie Menno A., van der Wal Allard C., Teunissen Marcel B. M. Comparison of Two Different Immunohistochemical Quadruple Staining Approaches to Identify Innate Lymphoid Cells in Formalin-fixed Paraffin-embedded Human Tissue journal of histochemistry and cytochemistry 2020;68 (2):127-138 [PubMed]
  • Willemsen Marcella, Luiten Rosalie M., Teunissen Marcel B. M. Instant isolation of highly purified human melanocytes from freshly prepared epidermal cell suspensions Pigment cell & melanoma research 2020;33 (5):763-766 [PubMed]
  • Dijkgraaf Feline E., Toebes Mireille, Hoogenboezem Mark, Mertz Marjolijn, Vredevoogd David W., Matos Tiago R., Teunissen Marcel B. M., Luiten Rosalie M., Schumacher Ton N. Labeling and tracking of immune cells in ex vivo human skin Nature protocols 2020 [PubMed]
  • Dyring-Andersen Beatrice, Løvendorf Marianne Bengtson, Coscia Fabian, Santos Alberto, Møller Line Bruun Pilgaard, Colaço Ana R., Niu Lili, Bzorek Michael, Doll Sophia, Andersen J. rgen Lock, Clark Rachael A., Skov Lone, Teunissen Marcel B. M., Mann Matthias Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin Nature communications 2020;11 (1) [PubMed]

2019

  • Bernink Jochem H., Ohne Yoichiro, Teunissen Marcel B. M., Wang Jingya, Wu Jincheng, Krabbendam Lisette, Guntermann Christine, Volckmann Richard, Koster Jan, van Tol Sophie, Ramirez Ivan, Shrestha Yashaswi, de Rie Menno A., Spits Hergen, Romero Ros Xavier, Humbles Alison A. c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies Nature immunology 2019;20 (8):992-1003 [PubMed]
  • dos Reis Matos Tiago Skin resident T cells: Implications for immune homeostasis and disease 2019. 428p. ISBN 9789463325233. [UvA Dissertations Online] University of Amsterdam. (Supervisors: de Rie Menno, Clark R. A.; Co-supervisor: Teunissen M. B. M.)
  • Dijkgraaf Feline E., Matos Tiago R., Hoogenboezem Mark, Toebes Mireille, Vredevoogd David W., Mertz Marjolijn, van den Broek Bram, Song Ji-Ying, Teunissen Marcel B. M., Luiten Rosalie M., Beltman Joost B., Schumacher Ton N. Tissue patrol by resident memory CD8+ T cells in human skin Nature immunology 2019;20 (6):756-764 [PubMed]

2018

  • Herfs Paul , Teunissen Marcel Evaluatie van de toelating van buitenlandse artsen: Hoogste tijd voor verbetering van procedure en organisatie A&MR Asiel&Migrantenrecht 2018 (5):212-218
  • Souwer Yuri, Groot Kormelink Tom, Taanman-Kueter Esther W., Muller Femke J., van Capel Toni M. M., Varga Domonkos V., Bar-Ephraim Yotam E., Teunissen Marcel B. M., van Ham S. Marieke, Kuijpers Taco W., Wouters Diana, Meyaard Linde, de Jong Esther C. Human Th17 cell development requires processing of dendritic cell-derived CXCL8 by neutrophil elastase Journal of allergy and clinical immunology 2018;141 (6):2286-2289.e5 [PubMed]

2017

  • Herfs Paul , Teunissen Marcel B. M. Assessment struikelblok voor buitenlandse artsen Medisch contact 2017;72 (49):28-29
  • Matos Tiago R., de Rie Menno A., Teunissen Marcel B. M. Research Techniques Made Simple: High-Throughput Sequencing of the T-Cell Receptor Journal of investigative dermatology 2017;137 (6):e131-e138 [PubMed]

2016

  • Ramos Maria I., Teunissen Marcel B. M., Helder Boy, Aarrass Saida, de Hair Maria J. H., van Kuijk Arno W., Gerlag Danielle M., Tak Paul P., Lebre Maria C. Reduced CLEC9A expression in synovial tissue of psoriatic arthritis patients after adalimumab therapy Rheumatology (Oxford, England) 2016;55 (9):1575-1584 [PubMed]

2015

  • Teunissen Marcel B. M., Zehrung Darin Cutaneous vaccination - Protective immunization is just a skin-deep step away Vaccine 2015;33 (37):4659-4662 [PubMed]

2014

  • Teunissen Marcel B. M., Munneke J. Marius, Bernink Jochem H., Spuls Phyllis I., Res Pieter C. M., te Velde Anje, Cheuk Stanley, Brouwer Marijke W. D., Menting Stef P., Eidsmo Liv, Spits Hergen, Hazenberg Mette D., Mjösberg Jenny Composition of innate lymphoid cell subsets in the human skin: enrichment of NCR(+) ILC3 in lesional skin and blood of psoriasis patients Journal of investigative dermatology 2014;134 (9):2351-2360 [PubMed]
  • Teunissen Marcel B. M., Yeremenko Nataliya G., Baeten Dominique L. P., Chielie Saskia, Spuls Phyllis I., de Rie Menno A., Lantz Olivier, Res Pieter C. M. The IL-17A-producing CD8+ T-cell population in psoriatic lesional skin comprises mucosa-associated invariant T cells and conventional T cells Journal of investigative dermatology 2014;134 (12):2898-2907 [PubMed]

2013

  • Bakdash Ghaith, Schneider Laura P., van Capel Toni M. M., Kapsenberg Martien L., Teunissen Marcel B. M., de Jong Esther C. Intradermal application of vitamin D3 increases migration of CD14+ dermal dendritic cells and promotes the development of Foxp3+ regulatory T cells Human vaccines & immunotherapeutics 2013;9 (2):250-258 [PubMed]
  • van der Aar Angelic M. G., Picavet Daisy I., Muller Femke J., de Boer Leonie, van Capel Toni M. M., Zaat Sebastian A. J., Bos Jan D., Janssen Hans, George Thaddeus C., Kapsenberg Martien L., van Ham S. Marieke, Teunissen Marcel B. M., de Jong Esther C. Langerhans cells favor skin flora tolerance through limited presentation of bacterial antigens and induction of regulatory T cells Journal of investigative dermatology 2013;133 (5):1240-1249 [PubMed]

2012

  • de Groot Marjan, Picavet Daisy I., van Kuijk Arno W. R., Tak Paul P., Bos Jan D., de Rie Menno A., Teunissen Marcel B. M. A Prospective, Randomized, Placebo-Controlled Study to Identify Biomarkers Associated with Active Treatment in Psoriatic Arthritis: Effects of Adalimumab Treatment on Lesional and Nonlesional Skin Dermatology (Basel, Switzerland) 2012;225 (4):298-303 [PubMed]
  • Szegedi Krisztina, Kremer Andreas E., Kezic Sanja, Teunissen Marcel B. M., Bos Jan D., Luiten Rosalie M., Res Pieter C., Middelkamp-Hup Maritza A. Increased frequencies of IL-31-producing T cells are found in chronic atopic dermatitis skin Experimental dermatology 2012;21 (6):431-436 [PubMed]
  • Teunissen M. B. M., Haniffa M., Collin M. P. Insight into the immunobiology of human skin and functional specialization of skin dendritic cell subsets to innovate intradermal vaccination design Current topics in microbiology and immunology 2012;351:25-76 [PubMed]
  • Schneider Laura P., Schoonderwoerd Antoinet J., Moutaftsi Magdalini, Howard Randall F., Reed Steven G., de Jong Esther C., Teunissen Marcel B. M. Intradermally administered TLR4 agonist GLA-SE enhances the capacity of human skin DCs to activate T cells and promotes emigration of Langerhans cells Vaccine 2012;30 (28):4216-4224 [PubMed]
  • Teunissen Marcel B. M., Zheng Ling, de Groot Marjan, de Rie Menno A., Fine Jay S., Chen Shu-Cheng Rise in dermal CD11c(+) dendritic cells associates with early-stage development of psoriatic lesions Archives of dermatological research 2012;304 (6):443-449 [PubMed]

2011

  • van der Aar Angelic M. G., de Groot Rosa, Sanchez-Hernandez Marta, Taanman Esther W. M., van Lier René A. W., Teunissen Marcel B. M., de Jong Esther C., Kapsenberg Martien L. Cutting Edge: Virus Selectively Primes Human Langerhans Cells for CD70 Expression Promoting CD8(+) T Cell Responses Journal of immunology (Baltimore, Md. 2011;187 (7):3488-3492 [PubMed]
  • de Groot Marjan Innovative therapies and new targets in psoriasis 2011. 156p. ISBN 9789490371760. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Bos J. D.; Co-supervisors: de Rie M. A., Teunissen M. B. M.)
  • van der Aar Angelic M. G., Sibiryak Darya S., Bakdash Ghaith, van Capel Toni M. M., van der Kleij Hanneke P. M., Opstelten Dirk-Jan E., Teunissen Marcel B. M., Kapsenberg Martien L., de Jong Esther C. Vitamin D3 targets epidermal and dermal dendritic cells for induction of distinct regulatory T cells Journal of allergy and clinical immunology 2011;127 (6):1532-U334 [PubMed]

2010

  • Chen Shu-Cheng, de Groot Marjan, Kinsley David, Laverty Maureen, McClanahan Terrill, Arreaza Maria, Gustafson Eric L., Teunissen Marcel B. M., de Rie Menno A., Fine Jay S., Kraan Maarten Expression of chemokine receptor CXCR3 by lymphocytes and plasmacytoid dendritic cells in human psoriatic lesions Archives of dermatological research 2010;302 (2):113-123 [PubMed]
  • van der Aar Angelic M. G. Functional specialization of human skin dendritic cell subsets in immunity to different slasses of pathogens 2010. 160p. ISBN 9789490371104. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Bos J. D., Kapsenberg M. L.; Co-supervisors: Teunissen M. B. M., de Jong E. C.)
  • Res Pieter C. M., Piskin Gamze, de Boer Onno J., van der Loos Chris M., Teeling Peter, Bos Jan D., Teunissen Marcel B. M. Overrepresentation of IL-17A and IL-22 Producing CD8 T Cells in Lesional Skin Suggests Their Involvement in the Pathogenesis of Psoriasis PLoS ONE 2010;5 (11):e14108 [PubMed]
  • de Groot Marjan, Teunissen Marcel B. M., Picavet Daisy I., de Rie Menno A., Bos Jan D. Reduction of different inflammatory cell types of the innate immune system in psoriatic skin during etanercept treatment Experimental dermatology 2010;19 (8):754-756 [PubMed]

2009

  • Kammeyer Arthur, Bos Jan D., Teunissen Marcel B. M. Postelicitation model of allergic contact dermatitis for predicting the efficacy of topical drugs Experimental dermatology 2009;18 (1):44-49 [PubMed]
  • Janssens A. S., Pavel S., Tensen C. P., Teunissen M. B. M., Out-Luiting J. J., Willemze R., de Gruijl F. R. Reduced IL-1Ra/IL-1 ratio in ultraviolet B-exposed skin of patients with polymorphic light eruption Experimental dermatology 2009;18 (3):212-217 [PubMed]

2007

  • van der Aar Angelic M. G., Sylva-Steenland Regien M. R., Bos Jan D., Kapsenberg Martien L., de Jong Esther C., Teunissen Marcel B. M. Cutting edge: Loss of TLR2, TLR4, and TLR5 on Langerhans cells abolishes bacterial recognition Journal of immunology (Baltimore, Md. 2007;178 (4):1986-1990 [PubMed]
  • de Groot Marjan, Teunissen Marcel B. M., Ortonne Jean P., Lambert Julien R., Naeyaert Jean M., Picavet Daisy I., Arreaza M. Gladys, Simon Jason S., Kraan Maarten, Bos Jan D., de Rie Menno A. Expression of the chemokine receptor CCR5 in psoriasis and results of a randomized placebo controlled trial with a CCR5 inhibitor Archives of dermatological research 2007;299 (7):305-313 [PubMed]
  • de Boer Onno J., van der Loos Chris M., Teeling Peter, van der Wal Allard C., Teunissen Marcel B. M. Immunohistochemical analysis of regulatory T cell markers FOXP3 and GITR on CD4(+) CD25(+) T cells in normal skin and inflammatory dermatoses journal of histochemistry and cytochemistry 2007;55 (9):891-898 [PubMed]
  • van Beelen Astrid J., Teunissen Marcel B. M., Kapsenberg Martien L., de Jong Esther C. Interleukin-17 in inflammatory skin disorders Current opinion in allergy and clinical immunology 2007;7 (5):374-381 [PubMed]
  • de Vries Henry J. C., Teunissen Marcel B. M., Zorgdrager Fokla, Picavet Daisy, Cornelissen Marion Lichen planus remission is associated with a decrease of human herpes virus type 7 protein expression in plasmacytoid dendritic cells Archives of dermatological research 2007;299 (4):213-219 [PubMed]
  • Teunissen M. B. M., Piskin G., Res P. C. J. M., de Groot M., Picavet D. I., de Rie M. A., Bos J. D. State of the art in the immunopathogenesis of psoriasis Giornale italiano di dermatologia e venereologia 2007;142:229-242

2006

  • de Vries H. J. C., van Marle J., Teunissen M. B. M., Picavet D., Zorgdrager F., Bos J. D., Weel J., Cornelissen M. De rol van humaan herpesvirus type 7(hhv-7) bij lichen planus Nederlands tijdschrift voor dermatologie en venereologie 2006;16 (dec):424-427
  • Piskin Gamze, Sylva-Steenland Regien M. R., Bos Jan D., Teunissen Marcel B. M. In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin Journal of immunology (Baltimore, Md. 2006;176 (3):1908-1915 [PubMed]
  • de Vries H. J. C., van Marle J., Teunissen M. B. M., Picavet D., Zorgdrager F., Bos J. D., Weel J., Cornelissen M. Lichen planus is associated with human herpesvirus type 7 replication and infiltration of plasmacytoid dendritic cells British journal of dermatology 2006;154 (2):361-364 [PubMed]

2005

  • Goedkoop Amber Y., de Rie Menno A., Teunissen Marcel B. M., Picavet Daisy I., van der Hall Pascal O., Bos Jan D., Tak Paul P., Kraan Maarten C. Digital image analysis for the evaluation of the inflammatory infiltrate in psoriasis Archives of dermatological research 2005;297 (2):51-59 [PubMed]
  • Goedkoop A. Y. Effects of biological response modifiers in psoriasis and psoriatic arthritis 2005. 172p. ISBN 9789090193120. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Bos J. D., Tak P. P.; Co-supervisors: de Rie M. A., Teunissen M. B. M.)
  • Teunissen M. B. M. Langerhans cells and other skin dendritic cellsin: J. D. Bos, editors. Skin immune system. Cutaneous immunology and clinical immunodermatology. Boca Raton, Florida: CRC Press; 2005. p. 123-182, ISBN 9780849319594
  • Piskin Gamze, Bos Jan D., Teunissen Marcel B. M. Neutrophils infiltrating ultraviolet B-irradiated normal human skin display high IL-10 expression Archives of dermatological research 2005;296 (7):339-342 [PubMed]
  • Bos J. D., de Rie M. A., Teunissen M. B. M., Piskin G. Psoriasis: dysregulation of innate immunity British journal of dermatology 2005;152 (6):1098-1107 [PubMed]

2004

  • Goedkoop Amber Y., de Rie Menno A., Picavet Daisy I., Kraan Maarten C., Dinant Huib J., van Kuijk Arno W. R., Tak Paul P., Bos Jan D., Teunissen Marcel B. M. Alefacept therapy reduces the effector T-cell population in lesional psoriatic epidermis Archives of dermatological research 2004;295 (11):465-473 [PubMed]
  • Piskin G., Tursen U., Sylva-Steenland R. M. R., Bos J. D., Teunissen M. B. M. Clinical improvement in chronic plaque-type psoriasis lesions after narrow-band UVB therapy is accompanied by a decrease in the expression of IFN-gamma inducers - IL-12, IL-18 and IL-23 Experimental dermatology 2004;13 (12):764-772 [PubMed]
  • Goedkoop Amber Y., Kraan Maarten C., Picavet Daisy I., de Rie Menno A., Teunissen Marcel B. M., Bos Jan D., Tak Paul P. Deactivation of endothelium and reduction in angiogenesis in psoriatic skin and synovium by low dose infliximab therapy in combination with stable methotrexate therapy: a prospective single-centre study Arthritis research & therapy 2004;6 (4):R326-R334 [PubMed]
  • Goedkoop A. Y., Kraan M. C., Teunissen M. B. M., Picavet D. I., de Rie M. A., Bos J. D., Tak P. P. Early effects of tumour necrosis factor alpha blockade on skin and synovial tissue in patients with active psoriasis and psoriatic arthritis Annals of the rheumatic diseases 2004;63 (7):769-773 [PubMed]
  • Piskin G. Effects of therapies on cytokine patterns in psoriasis 2004. 195p. ISBN 9789090182421. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Bos J. D.; Co-supervisor: Teunissen M. B. M.)
  • Piskin G., Sylva-Steenland M. R., Bos J. D., Teunissen M. B. M. Effect van behandeling met UVB op psoriasis Nederlands tijdschrift voor dermatologie en venereologie 2004;14 (6):200-201
  • Goedkoop A. Y., Kraan M. C., Tak P. P., Bos J. D., de Rie M. A., Picavet H. S. J., Teunissen M. B. M. In vitro studies met biologicals in psoriasis Nederlands tijdschrift voor dermatologie en venereologie 2004;14 (juni):202-204
  • Kammeyer Arthur, Garssen Johan, Sleijffers Annemarie, van Loveren Henk, Eggelte Teunis A., Bos Jan D., Teunissen Marcel B. M. Suppression of different phases of systemic contact hypersensitivity by urocanic acid oxidation products Photochemistry and photobiology 2004;80 (1):72-77 [PubMed]
  • Piskin Gamze, Sylva-Steenland Regien M. R., Bos Jan D., Teunissen Marcel B. M. T cells in psoriatic lesional skin that survive conventional therapy with NB-UVB radiation display reduced IFN-gamma expression Archives of dermatological research 2004;295 (12):509-516 [PubMed]

2003

  • Piskin Gamze, Heydendael Vera M. R., de Rie Menno A., Bos Jan D., Teunissen Marcel B. M. Cyclosporin A and methotrexate are equally effective in reducing T cell numbers in psoriatic skin lesions but have no consistent effect on IFN-gamma and IL-4 expression in psoriatic skin in situ Archives of dermatological research 2003;294 (12):559-562 [PubMed]
  • Sleijffers Annemarie, Kammeyer Arthur, de Gruijl Frank R., Boland Greet J., van Hattum Jan, van Vloten Willem A., van Loveren Henk, Teunissen Marcel B. M., Garssen Johan Epidermal cis-urocanic acid levels correlate with lower specific cellular immune responses after hepatitis B vaccination of ultraviolet B-exposed humans Photochemistry and photobiology 2003;77 (3):271-275 [PubMed]
  • Piskin Gamze, Tursen Umit, Bos Jan D., Teunissen Marcel B. M. IL-4 expression by neutrophils in psoriasis lesional skin upon high-dose UVB exposure Dermatology (Basel, Switzerland) 2003;207 (1):51-53 [PubMed]
  • Piskin Gamze, Koomen Cornelis W., Picavet Daisy, Bos Jan D., Teunissen Marcel B. M. Ultraviolet-B irradiation decreases IFN-gamma and increases IL-4 expression in psoriatic lesional skin in situ and in cultured dermal T cells derived from these lesions Experimental dermatology 2003;12 (2):172-180 [PubMed]

2002

  • Teunissen Marcel B. M., Piskin Gamze, Di Nuzzo Sergio, Sylva-Steenland Regien M. R., de Rie Menno A., Bos Jan D. Ultraviolet B radiation induces a transient appearance of IL-4(+) neutrophils, which support the development of Th2 responses Journal of immunology (Baltimore, Md. 2002;168 (8):3732-3739 [PubMed]
  • Di Nuzzo Sergio, Sylva-Steenland Regien M. R., Koomen Cornelis W., Nakagawa Satoshi, van Breemen Marielle, de Rie Menno A., Das Pranab K., Bos Jan D., Teunissen Marcel B. M. UVB irradiation of normal human skin favors the development of type-2 T-cells in vivo and in primary dermal cell cultures Photochemistry and photobiology 2002;76 (3):301-309 [PubMed]

2001

  • Kammeyer A., Eggelte T. A., Overmars H., Bootsma A., Bos J. D., Teunissen M. B. Oxidative breakdown and conversion of urocanic acid isomers by hydroxyl radical generating systems BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 2001;1526 (3):277-285 [PubMed]
  • Vissers J. L., Hartgers F. C., Lindhout E., Teunissen M. B., Figdor C. G., Adema G. J. Quantitative analysis of chemokine expression by dendritic cell subsets in vitro and in vivo Journal of leukocyte biology 2001;69 (5):785-793 [PubMed]

2000

  • Di Nuzzo S., Sylva-Steenland R. M., Koomen C. W., de Rie M. A., Das P. K., Bos J. D., Teunissen M. B. Exposure to UVB induces accumulation of LFA-1+ T cells and enhanced expression of the chemokine psoriasin in normal human skin Photochemistry and photobiology 2000;72 (3):374-382 [PubMed]

1999

  • Nakagawa S., Koomen C. W., Bos J. D., Teunissen M. B. Differential modulation of human epidermal Langerhans cell maturation by ultraviolet B radiation Journal of immunology (Baltimore, Md. 1999;163 (10):5192-5200 [PubMed]
  • Kammeyer A., Eggelte T. A., Bos J. D., Teunissen M. B. Urocanic acid isomers are good hydroxyl radical scavengers: a comparative study with structural analogues and with uric acid BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1999;1428 (1):117-120 [PubMed]

1998

  • Teunissen M. B., Koomen C. W., de Waal Malefyt R., Wierenga E. A., Bos J. D. Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes Journal of investigative dermatology 1998;111 (4):645-649 [PubMed]
  • Kremer I. B., Cooper K. D., Teunissen M. B., Stevens S. R. Low expression of CD40 and B7 on macrophages infiltrating UV-exposed human skin; role in IL-2Ralpha-T cell activation European journal of immunology 1998;28 (9):2936-2946 [PubMed]
  • Gilliam A. C., Kremer I. B., Yoshida Y., Stevens S. R., Tootell E., Teunissen M. B., Hammerberg C., Cooper K. D. The human hair follicle: a reservoir of CD40+ B7-deficient Langerhans cells that repopulate epidermis after UVB exposure Journal of investigative dermatology 1998;110 (4):422-427 [PubMed]
  • Di Nuzzo S., Sylva-Steenland R. M., de Rie M. A., Das P. K., Bos J. D., Teunissen M. B. UVB radiation preferentially induces recruitment of memory CD4+ T cells in normal human skin: long-term effect after a single exposure Journal of investigative dermatology 1998;110 (6):978-981 [PubMed]

1997

  • Kremer I. B., Sylva-Steenland R. M., Bos J. D., Teunissen M. B. Despite the presence of UVB-induced DNA damage, HLA-DR+ cells from ex vivo UVB-exposed human skin are able to migrate and show no impaired allostimulatory capacity Journal of investigative dermatology 1997;109 (5):626-631 [PubMed]
  • Teunissen M. B., Koomen C. W., Jansen J., de Waal Malefyt R., Schmitt E., van den Wijngaard R. M., Das P. K., Bos J. D. In contrast to their murine counterparts, normal human keratinocytes and human epidermoid cell lines A431 and HaCaT fail to express IL-10 mRNA and protein Clinical and experimental immunology 1997;107 (1):213-223 [PubMed]
  • Kammeyer A., Pavel S., Asghar S. S., Bos J. D., Teunissen M. B. Prolonged increase of cis-urocanic acid levels in human skin and urine after single total-body ultraviolet exposures Photochemistry and photobiology 1997;65 (3):593-598 [PubMed]

1996

  • Kammeyer A., Meinardi M. M., Bos J. D., Teunissen M. B. cis-urocanic acid is not useful as an immunosuppressive agent in the treatment of human allergic contact dermatitis Archives of dermatological research 1996;288 (11):725-727 [PubMed]
  • Kremer I. B., Hilkens C. M., Sylva-Steenland R. M., Koomen C. W., Kapsenberg M. L., Bos J. D., Teunissen M. B. Reduced IL-12 production by monocytes upon ultraviolet-B irradiation selectively limits activation of T helper-1 cells Journal of immunology (Baltimore, Md. 1996;157 (5):1913-1918 [PubMed]
  • Di Nuzzo S., de Rie M. A., van der Loos C. M., Bos J. D., Teunissen M. B. Solar-simulated ultraviolet irradiation induces selective influx of CD4+ T lymphocytes in normal human skin Photochemistry and photobiology 1996;64 (6):988-993 [PubMed]

1995

  • Teunissen M. B., Koomen C. W., Bos J. D. Intercellular adhesion molecule-3 (CD50) on human epidermal Langerhans cells participates in T-cell activation Journal of investigative dermatology 1995;104 (6):995-998 [PubMed]
  • Kammeyer A., Teunissen M. B., Pavel S., de Rie M. A., Bos J. D. Photoisomerization spectrum of urocanic acid in human skin and in vitro: effects of simulated solar and artificial ultraviolet radiation British journal of dermatology 1995;132 (6):884-891 [PubMed]

1994

  • Teunissen M. B., Rongen H. A., Bos J. D. Function of adhesion molecules lymphocyte function-associated antigen-3 and intercellular adhesion molecule-1 on human epidermal Langerhans cells in antigen-specific T cell activation Journal of immunology (Baltimore, Md. 1994;152 (7):3400-3409 [PubMed]

1993

  • Teunissen M. B., Sylva-Steenland R. M., Bos J. D. Effect of low-dose ultraviolet-B radiation on the function of human T lymphocytes in vitro Clinical and experimental immunology 1993;94 (1):208-213 [PubMed]

1992

  • Teunissen M. B. Dynamic nature and function of epidermal Langerhans cells in vivo and in vitro: a review, with emphasis on human Langerhans cells Histochemical journal 1992;24 (10):697-716 [PubMed]
  • Teunissen M. B. Functional role of adhesion molecules LFA-3 and ICAM-1 on cultured human epidermal Langerhans cells in antigen-specific T-cell activation Journal of investigative dermatology 1992;99 (5):77S-79S [PubMed]

1991

  • Teunissen M. B., de Jager M. H., Kapsenberg M. L., Bos J. D. Inhibitory effect of cyclosporin A on antigen and alloantigen presenting capacity of human epidermal Langerhans cells British journal of dermatology 1991;125 (4):309-316 [PubMed]

1990

  • Teunissen M. B., Wormmeester J., Krieg S. R., Peters P. J., Vogels I. M., Kapsenberg M. L., Bos J. D. Human epidermal Langerhans cells undergo profound morphologic and phenotypical changes during in vitro culture Journal of investigative dermatology 1990;94 (2):166-173 [PubMed]
  • Bos J. D., Teunissen M. B., Cairo I., Krieg S. R., Kapsenberg M. L., Das P. K., Borst J. T-cell receptor gamma delta bearing cells in normal human skin Journal of investigative dermatology 1990;94 (1):37-42 [PubMed]

1988

  • Teunissen M. B., Wormmeester J., Kapsenberg M. L., Bos J. D. Enrichment of unlabeled human Langerhans cells from epidermal cell suspensions by discontinuous density gradient centrifugation Journal of investigative dermatology 1988;91 (4):358-362 [PubMed]

1987

  • Kapsenberg M. L., Res P., Bos J. D., Schootemijer A., Teunissen M. B., van Schooten W. Nickel-specific T lymphocyte clones derived from allergic nickel-contact dermatitis lesions in man: heterogeneity based on requirement of dendritic antigen-presenting cell subsets European journal of immunology 1987;17 (6):861-865 [PubMed]
  • Goudsmit J., Lange J. M., Krone W. J., Teunissen M. B., Epstein L. G., Danner S. A., van den Berg H., Breederveld C., Smit L., Bakker M. Pathogenesis of HIV and its implications for serodiagnosis and monitoring of antiviral therapy Journal of virological methods 1987;17 (1-2):19-34 [PubMed]

1986

  • Kapsenberg M. L., Teunissen M. B., Stiekema F. E., Keizer H. G. Antigen-presenting cell function of dendritic cells and macrophages in proliferative T cell responses to soluble and particulate antigens European journal of immunology 1986;16 (4):345-350 [PubMed]

1985

  • Kapsenberg M. L., Stiekema F. E., Teunissen M. B. Dendritic cells and macrophages as antigen presenting cells in ovalbumin-induced T lymphocyte proliferation in vitro Advances in experimental medicine and biology 1985;186:389-394 [PubMed]
  • Teunissen M. B., Kapsenberg M. L., Stiekema F. E., Keizer H. G. Dendritic cells as accessory cells in antigen-specific murine T lymphocyte proliferation in vitro Journal of immunological methods 1985;77 (1):131-138 [PubMed]

1984

  • Teunissen M. B., Kapsenberg M. L. Antigen-presenting cells in the proliferative T lymphocyte response in vitro: different mechanisms of antigen handling Cell biology international reports 1984;8 (3):184 [PubMed]