M.J. van Gils PhD publications

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Publications PhD M.J. van Gils

Position
Associate Professor
Main activities
Research
Specialisation
vaccine immunology with the focus on antibodies
Focus of research

The van Gils lab is committed to make a lasting impact on the field of vaccine immunology. Our mission is to comprehend the underlying immunology behind vaccination, in particular the elicitation of antibody responses. These antibody responses are vital in the protection against infectious diseases and the major goal in vaccine research is to induce potent antibodies. We believe that the protective effects of antibody responses are to a major extent imprinted during the first encounters of B and T cells with vaccines. Therefore, gaining knowledge and control over the initial interactions of vaccine candidates with B and T cells and the formation of germinal center responses, will guide the development and improvement of vaccines against infectious diseases. Therefore, we focus on determining phenotypic characteristics of B and Tfh cells and the interactions between these cells correlated with lifelong immunity after common childhood vaccines and after experimental vaccines. We use different techniques such as RNA sequencing, T and B cell receptor analysis and monoclonal antibody isolation to characterize the phenotype, affinity, and specificity of the antigen-specific B and T cells. Through this, we will provide new insights directed towards improving vaccines with the ultimate goal to elicit durable protective immune responses against infectious diseases, such as HIV, HCV and Influenza.

Amsterdam UMC Research Institutes
AMC departments
All publications

2020

  • Larsen Mads Delbo, de Graaf Erik L, Sonneveld Myrthe E, Plomp H Rosina, Nouta Jan, Hoepel Willianne, Chen Hung-Jen, Linty Federica, Visser Remco, Brinkhaus Maximilian, Šuštić Tonći, de Taeye Steven W, Bentlage Arthur E H, Toivonen Suvi, Koeleman Carolien A M, Sainio Susanna, Kootstra Neeltje A, Brouwer Philip J M, Geyer Chiara Elisabeth, Derksen Ninotska I L, Wolbink Gertjan, de Winther Menno, Sanders Rogier W, van Gils Marit J, de Bruin Sanne, Vlaar Alexander P J, Rispens Theo, den Dunnen Jeroen, Zaaijer Hans L, Wuhrer Manfred, Ellen van der Schoot C, Vidarsson Gestur Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity Science 2020 [PubMed]
  • Wu Nicholas C., Yuan Meng, Liu Hejun, Lee Chang-Chun D., Zhu Xueyong, Bangaru Sandhya, Torres Jonathan L., Caniels Tom G., Brouwer Philip J. M., van Gils Marit J., Sanders Rogier W., Ward Andrew B., Wilson Ian A. An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain Cell reports 2020;33 (3) [PubMed]
  • Yang Yuhe R., McCoy Laura E., van Gils Marit J., Andrabi Raiees, Turner Hannah L., Yuan Meng, Cottrell Christopher A., Ozorowski Gabriel, Voss James, Pauthner Matthias, Polveroni Thomas M., Messmer Terrence, Wilson Ian A., Sanders Rogier W., Burton Dennis R., Ward Andrew B. Autologous Antibody Responses to an HIV Envelope Glycan Hole Are Not Easily Broadened in Rabbits Journal of virology 2020;94 (7) [PubMed]
  • Pickering Suzanne, Betancor Gilberto, Galão Rui Pedro, Merrick Blair, Signell Adrian W., Wilson Harry D., Kia Ik Mark Tan, Seow Jeffrey, Graham Carl, Acors Sam, Kouphou Neophytos, Steel Kathryn J. A., Hemmings Oliver, Patel Amita, Nebbia Gaia, Douthwaite Sam, O'Connell Lorcan, Luptak Jakub, McCoy Laura E., Brouwer Philip, van Gils Marit J., Sanders Rogier W., Martinez Nunez Rocio, Bisnauthsing Karen, O'Hara Geraldine, MacMahon Eithne, Batra Rahul, Malim Michael H., Neil Stuart J. D., Doores Katie J., Edgeworth Jonathan D. Comparative assessment of multiple COVID-19 serological technologies supports continued evaluation of point-of-care lateral flow assays in hospital and community healthcare settings PLoS pathogens 2020;16 (9):e1008817 [PubMed]
  • Liu Hejun, Wu Nicholas C, Yuan Meng, Bangaru Sandhya, Torres Jonathan L, Caniels Tom G, van Schooten Jelle, Zhu Xueyong, Lee Chang-Chun D, Brouwer Philip J M, van Gils Marit J, Sanders Rogier W, Ward Andrew B, Wilson Ian A Cross-Neutralization of a SARS-CoV-2 Antibody to a Functionally Conserved Site Is Mediated by Avidity Immunity 2020;53 (6):1272-1280.e5 [PubMed]
  • de Jong Nina M. C., Aartse Aafke, van Gils Marit J., Eggink Dirk Development of broadly reactive influenza vaccines by targeting the conserved regions of the hemagglutinin stem and head domains Expert review of vaccines 2020;19 (6):563-577 [PubMed]
  • van der Velden Yme U., Villaudy Julien, Siteur - van Rijnstra Esther, van der Linden Cynthia A., Vink Monique A., Schermer Edith E., Weijer Kees, Berkhout Ben, Sanders Rogier W., van Gils Marit J. Diverse HIV-1 escape pathways from broadly neutralizing antibody PGDM1400 in humanized mice mAbs 2020;12 (1) [PubMed]
  • Reiss Emma I. M. M., van Gils Marit J., Sanders Rogier W., de Bree Godelieve J. Een hiv-vaccin: Hoe ver zijn we? Nederlands tijdschrift voor geneeskunde 2020;164 (37)
  • Derking Ronald, Allen Joel D., Cottrell Christopher A., Sliepen Kwinten, Seabright Gemma E., Lee Wen-Hsin, Rantalainen Kimmo, Antanasijevic Aleksandar, Copps Jeffrey, Yasmeen Anila, van der Woude Patricia, de Taeye Steven W., van den Kerkhof Tom L.G.M., Klasse P.J., Ozorowski Gabriel, van Gils Marit J., Moore John P., Ward Andrew B., Crispin Max, Sanders Rogier W. Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike bioRxiv 2020
  • de Boer Esther C. W., van Gils Janine M., van Gils Marit J. Ephrin-Eph signaling usage by a variety of viruses Pharmacological research 2020;159:105038 [PubMed]
  • Bruikman Caroline S. Familial atherosclerosis and neuroimmune guidance cues: From in vitro assessments to clinical events 2020. 197p. ISBN 9789463758857. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Hovingh Gerard K.; Co-supervisor: van Gils Marit J.)
  • Nogal Bartek, McCoy Laura E., van Gils Marit J., Cottrell Christopher A., Voss James E., Andrabi Raiees, Pauthner Matthias, Liang Chi-Hui, Messmer Terrence, Nedellec Rebecca, Shin Mia, Turner Hannah L., Ozorowski Gabriel, Sanders Rogier W., Burton Dennis R., Ward Andrew B. HIV envelope trimer-elicited autologous neutralizing antibodies bind a region overlapping the N332 glycan supersite Science advances 2020;6 (23) [PubMed]
  • Cottrell Christopher A., van Schooten Jelle, Bowman Charles A., Yuan Meng, Oyen David, Shin Mia, Morpurgo Robert, van der Woude Patricia, van Breemen Marielle, Torres Jonathan L., Patel Raj, Gross Justin, Sewall Leigh M., Copps Jeffrey, Ozorowski Gabriel, Nogal Bartek, Sok Devin, Rakasz Eva G., Labranche Celia, Vigdorovich Vladimir, Christley Scott, Carnathan Diane G., Sather D. Noah, Montefiori David, Silvestri Guido, Burton Dennis R., Moore John P., Wilson Ian A., Sanders Rogier W., Ward Andrew B., van Gils Marit J. Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates PLoS pathogens 2020;16 (8) [PubMed]
  • Seabright Gemma E., Cottrell Christopher A., van Gils Marit J., D'addabbo Alessio, Harvey David J., Behrens Anna-Janina, Allen Joel D., Watanabe Yasunori, Scaringi Nicole, Polveroni Thomas M., Maker Allison, Vasiljevic Snezana, de Val Natalia, Sanders Rogier W., Ward Andrew B., Crispin Max Networks of HIV-1 Envelope Glycans Maintain Antibody Epitopes in the Face of Glycan Additions and Deletions Structure (London, England 2020;28 (8):897-909.e6 [PubMed]
  • Kemp S A, Collier D A, Datir R, Ferreira Iatm, Gayed S, Jahun A, Hosmillo M, Rees-Spear C, Mlcochova P, Lumb Ines Ushiro, Roberts David J, Chandra Anita, Temperton N, Sharrocks K, Blane E, Briggs Jag, van Gils M J, Smith Kgc, Bradley J R, Smith C, Doffinger R, Ceron-Gutierrez L, Barcenas-Morales G, Pollock D D, Goldstein R A, Smielewska A, Skittrall J P, Gouliouris T, Goodfellow I G, Gkrania-Klotsas E, Illingworth Cjr, McCoy L E, Gupta R K Neutralising antibodies in Spike mediated SARS-CoV-2 adaptation medRxiv 2020 [PubMed]
  • Schorcht Anna, van den Kerkhof Tom L. G. M., Cottrell Christopher A., Allen Joel D., Torres Jonathan L., Behrens Anna-Janina, Schermer Edith E., Burger Judith A., de Taeye Steven W., Torrents de la Peña Alba, Bontjer Ilja, Gumbs Stephanie, Ozorowski Gabriel, LaBranche Celia C., de Val Natalia, Yasmeen Anila, Klasse Per Johan, Montefiori David C., Moore John P., Schuitemaker Hanneke, Crispin Max, van Gils Marit J., Ward Andrew B., Sanders Rogier W. Neutralizing Antibody Responses Induced by HIV-1 Envelope Glycoprotein SOSIP Trimers Derived from Elite Neutralizers Journal of virology 2020;94 (24) [PubMed]
  • Brouwer Philip J.M., Caniels Tom G., van der Straten Karlijn, Snitselaar Jonne L., Aldon Yoann, Bangaru Sandhya, Torres Jonathan L., Okba Nisreen M.A., Claireaux Mathieu, Kerster Gius, Bentlage Arthur E.H., van Haaren Marlies M., Guerra Denise, Burger Judith A., Schermer Edith E., Verheul Kirsten D., van der Velde Niels, van der Kooi Alex, van Schooten Jelle, van Breemen Mariëlle J., Bijl Tom P.L., Sliepen Kwinten, Aartse Aafke, Derking Ronald, Bontjer Ilja, Kootstra Neeltje A., Joost Wiersinga W., Vidarsson Gestur, Haagmans Bart L., Ward Andrew B., de Bree Godelieve J., Sanders Rogier W., van Gils Marit J. Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability Science 2020;369 (6504):643-650 [PubMed]
  • Schommers Philipp, Gruell Henning, Abernathy Morgan E., Tran My-Kim, Dingens Adam S., Gristick Harry B., Barnes Christopher O., Schoofs Till, Schlotz Maike, Vanshylla Kanika, Kreer Christoph, Weiland Daniela, Holtick Udo, Scheid Christof, Valter Markus M., van Gils Marit J., Sanders Rogier W., Vehreschild J. rg J., Cornely Oliver A., Lehmann Clara, Fätkenheuer Gerd, Seaman Michael S., Bloom Jesse D., Bjorkman Pamela J., Klein Florian Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody Cell 2020;180 (3):471-489.e22 [PubMed]
  • Bermejo-Jambrina Marta, Eder Julia, Kaptein Tanja M., Helgers Leanne C., Brouwer Philip J.M., van Hamme John L., Vlaar Alexander P.J., van Baarle Frank E.H.P., de Bree Godelieve J., Nijmeijer Bernadien M., Koostra Neeltje A., van Gils Marit J., Sanders Rogier W., Geijtenbeek Teunis B. H. SARS-CoV-2 Infection and Transmission Depends on Heparan Sulfates and Is Blocked by Low Molecular Weight Heparins bioRxiv 2020
  • Bruikman Caroline S., Vreeken Dianne, Zhang Huayu, van Gils Marit J., Peter Jorge, van Zonneveld Anton Jan, Hovingh G. Kees, van Gils Janine M. The identification and function of a Netrin-1 mutation in a pedigree with premature atherosclerosis Atherosclerosis 2020;301:84-92 [PubMed]
  • Brouwer Philip J. M., Brinkkemper Mitch, Maisonnasse Pauline, Dereuddre-Bosquet Nathalie, Grobben Marloes, Claireaux Mathieu, de Gast Marlon, Marlin Romain, Chesnais Virginie, Diry Ségolène, Allen Joel D., Watanabe Yasunori, Giezen Julia M., Kerster Gius, Turner Hannah L., van der Straten Karlijn, van der Linden Cynthia A., Aldon Yoann, Naninck Thibaut, Bontjer Ilja, Burger Judith A., Poniman Meliawati, Mykytyn Anna Z., Okba Nisreen M. A., Schermer Edith E., van Breemen Marielle J., Ravichandran Rashmi, Caniels Tom G., van Schooten Jelle, Kahlaoui Nidhal, Contreras Vanessa, Lemaitre Julien, Chapon Catherine, Ho Tsong Fang Raphaël, Villaudy Julien, Sliepen Kwinten, van der Velden Yme U., Haagmans Bart L., de Bree Godelieve J., Ginoux Eric, Ward Andrew B., Crispin Max, King Neil P., van der Werf Sylvie, van Gils Marit J., Grand Roger Le, Sanders Rogier W. Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection bioRxiv 2020
  • Berndsen Zachary T., Chakraborty Srirupa, Wang Xiaoning, Cottrell Christopher A., Torres Jonathan L., Diedrich Jolene K., López Cesar A., Yates John R., van Gils Marit J., Paulson James C., Gnanakaran Sandrasegaram, Ward Andrew B. Visualization of the HIV-1 Env glycan shield across scales Proceedings of the National Academy of Sciences of the United States of America 2020;117 (45):28014-28025 [PubMed]

2019

  • Gach Johannes S., Mara Kane J. V., LaBranche Celia C., van Gils Marit J., McCoy Laura E., Klasse P. J., Montefiori David C., Sanders Rogier W., Moore John P., Forthal Donald N. Antibody Responses Elicited by Immunization with BG505 Trimer Immune Complexes Journal of virology 2019;93 (20) [PubMed]
  • Ringe Rajesh P., Pugach Pavel, Cottrell Christopher A., LaBranche Celia C., Seabright Gemma E., Ketas Thomas J., Ozorowski Gabriel, Kumar Sonu, Schorcht Anna, van Gils Marit J., Crispin Max, Montefiori David C., Wilson Ian A., Ward Andrew B., Sanders Rogier W., Klasse P. J., Moore John P. Closing and Opening Holes in the Glycan Shield of HIV-1 Envelope Glycoprotein SOSIP Trimers Can Redirect the Neutralizing Antibody Response to the Newly Unmasked Epitopes Journal of virology 2019;93 (4) [PubMed]
  • Yuan Meng, Cottrell Christopher A., Ozorowski Gabriel, van Gils Marit J., Kumar Sonu, Wu Nicholas C., Sarkar Anita, Torres Jonathan L., de Val Natalia, Copps Jeffrey, Moore John P., Sanders Rogier W., Ward Andrew B., Wilson Ian A. Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies......... Cell host & microbe 2019;25 (6):873-883.e5 [PubMed]
  • Brouwer Philip J. M., Antanasijevic Aleksandar, Berndsen Zachary, Yasmeen Anila, Fiala Brooke, Bijl Tom P. L., Bontjer Ilja, Bale Jacob B., Sheffler William, Allen Joel D., Schorcht Anna, Burger Judith A., Camacho Miguel, Ellis Daniel, Cottrell Christopher A., Behrens Anna-Janina, Catalano Marco, del Moral-Sánchez Iván, Ketas Thomas J., LaBranche Celia, van Gils Marit J., Sliepen Kwinten, Stewart Lance J., Crispin Max, Montefiori David C., Baker David, Moore John P., Klasse Per Johan, Ward Andrew B., King Neil P., Sanders Rogier W. Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle Nature communications 2019;10 (1):4272 [PubMed]
  • Euler Zelda, VAN DEN Kerkhof Tom L., Kouyos Roger D., Tully Damien C., Allen Todd M., Trkola Alexandra, Sanders Rogier W., Schuitemaker Hanneke, VAN Gils Marit J. Lower Broadly Neutralizing Antibody Responses in Female Versus Male HIV-1 Infected Injecting Drug Users Viruses 2019;11 (4) [PubMed]
  • Torrents de la Peña Alba, Rantalainen Kimmo, Cottrell Christopher A., Allen Joel D., van Gils Marit J., Torres Jonathan L., Crispin Max, Sanders Rogier W., Ward Andrew B. Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics PLoS pathogens 2019;15 (7):e1007920 [PubMed]
  • Sliepen Kwinten, Han Byung Woo, Bontjer Ilja, Mooij Petra, Garces Fernando, Behrens Anna-Janina, Rantalainen Kimmo, Kumar Sonu, Sarkar Anita, Brouwer Philip J. M., Hua Yuanzi, Tolazzi Monica, Schermer Edith, Torres Jonathan L., Ozorowski Gabriel, van der Woude Patricia, de la Peña Alba Torrents, van Breemen Mariëlle J., Camacho-Sánchez Juan Miguel, Burger Judith A., Medina-Ramírez Max, González Nuria, Alcami Jose, LaBranche Celia, Scarlatti Gabriella, van Gils Marit J., Crispin Max, Montefiori David C., Ward Andrew B., Koopman Gerrit, Moore John P., Shattock Robin J., Bogers Willy M., Wilson Ian A., Sanders Rogier W. Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence Nature communications 2019;10 (1) [PubMed]
  • Grobben Marloes, Stuart Richard A. L., van Gils Marit J. The potential of engineered antibodies for HIV-1 therapy and cure Current opinion in virology 2019;38:70-80 [PubMed]

2018

  • Klasse P. J., Ketas Thomas J., Cottrell Christopher A., Ozorowski Gabriel, Debnath Gargi, Camara Diawoye, Francomano Erik, Pugach Pavel, Ringe Rajesh P., LaBranche Celia C., van Gils Marit J., Bricault Christine A., Barouch Dan H., Crotty Shane, Silvestri Guido, Kasturi Sudhir, Pulendran Bali, Wilson Ian A., Montefiori David C., Sanders Rogier W., Ward Andrew B., Moore John P. Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques PLoS pathogens 2018;14 (2):e1006913 [PubMed]
  • van Gils Marit J., Sanders Rogier W. Hitting HIV's Harpoon Immunity 2018;49 (1):14-15 [PubMed]
  • van Schooten Jelle, van Gils Marit J. HIV-1 immunogens and strategies to drive antibody responses towards neutralization breadth Retrovirology 2018;15 (1):74 [PubMed]
  • van der Velden Yme U., Villaudy Julien, Siteur-van Rijnstra Esther, van der Linden Cynthia A., Frankin Esmay, Weijer Kees, Schermer Edith, Vink Monique A., Berkhout Ben, Sanders Rogier W., van Gils Marit J. Short Communication: Protective Efficacy of Broadly Neutralizing Antibody PGDM1400 Against HIV-1 Challenge in Humanized Mice AIDS research and human retroviruses 2018;34 (9):790-793 [PubMed]
  • de Taeye Steven W., Torrents de la Peña Alba, Vecchione Andrea, Scutigliani Enzo, Sliepen Kwinten, Burger Judith A., van der Woude Patricia, Schorcht Anna, Schermer Edith E., van Gils Marit J., LaBranche Celia C., Montefiori David C., Wilson Ian A., Moore John P., Ward Andrew B., Sanders Rogier W. Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers Journal of biological chemistry 2018;293 (5):1688-1701 [PubMed]

2017

  • Freund Natalia T., Wang Haoqing, Scharf Louise, Nogueira Lilian, Horwitz Joshua A., Bar-On Yotam, Golijanin Jovana, Sievers Stuart A., Sok Devin, Cai Hui, Cesar Lorenzi Julio C., Halper-Stromberg Ariel, Toth Ildiko, Piechocka-Trocha Alicja, Gristick Harry B., van Gils Marit J., Sanders Rogier W., Wang Lai-Xi, Seaman Michael S., Burton Dennis R., Gazumyan Anna, Walker Bruce D., West Anthony P., Bjorkman Pamela J., Nussenzweig Michel C. Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller Science translational medicine 2017;9 (373):eaal2144 [PubMed]
  • Torrents de la Peña Alba, Julien Jean-Philippe, de Taeye Steven W., Garces Fernando, Guttman Miklos, Ozorowski Gabriel, Pritchard Laura K., Behrens Anna-Janina, Go Eden P., Burger Judith A., Schermer Edith E., Sliepen Kwinten, Ketas Thomas J., Pugach Pavel, Yasmeen Anila, Cottrell Christopher A., Torres Jonathan L., Vavourakis Charlotte D., van Gils Marit J., Labranche Celia, Montefiori David C., Desaire Heather, Crispin Max, Klasse Per Johan, Lee Kelly K., Moore John P., Ward Andrew B., Wilson Ian A., Sanders Rogier W. Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization Cell reports 2017;20 (8):1805-1817 [PubMed]
  • van Haaren Marlies M., van den Kerkhof Tom L. G. M., van Gils Marit J. Natural infection as a blueprint for rational HIV vaccine design Human vaccines & immunotherapeutics 2017;13 (1):229-236 [PubMed]
  • van Gils Marit J., Sanders Rogier W. Opposites attract in bispecific antibody engineering Journal of biological chemistry 2017;292 (35):14718-14719 [PubMed]

2016

  • van Gils Marit J., van den Kerkhof Tom L. G. M., Ozorowski Gabriel, Cottrell Christopher A., Sok Devin, Pauthner Matthias, Pallesen Jesper, de Val Natalia, Yasmeen Anila, de Taeye Steven W., Schorcht Anna, Gumbs Stephanie, Johanna Inez, Saye-Francisco Karen, Liang Chi-Hui, Landais Elise, Nie Xiaoyan, Pritchard Laura K., Crispin Max, Kelsoe Garnett, Wilson Ian A., Schuitemaker Hanneke, Klasse Per Johan, Moore John P., Burton Dennis R., Ward Andrew B., Sanders Rogier W. An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability Nature microbiology 2016;2 (2):16199 [PubMed]
  • Havenar-Daughton Colin, Carnathan Diane G., Torrents de la Peña Alba, Pauthner Matthias, Briney Bryan, Reiss Samantha M., Wood Jennifer S., Kaushik Kirti, van Gils Marit J., Rosales Sandy L., van der Woude Patricia, Locci Michela, Le Khoa M., de Taeye Steven W., Sok Devin, Mohammed Ata Ur Rasheed, Huang Jessica, Gumber Sanjeev, Garcia AnaPatricia, Kasturi Sudhir P., Pulendran Bali, Moore John P., Ahmed Rafi, Seumois Grégory, Burton Dennis R., Sanders Rogier W., Silvestri Guido, Crotty Shane Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer Cell reports 2016;17 (9):2195-2209 [PubMed]
  • van den Kerkhof Tom L. G. M., de Taeye Steven W., Boeser-Nunnink Brigitte D., Burton Dennis R., Kootstra Neeltje A., Schuitemaker Hanneke, Sanders Rogier W., van Gils Marit J. HIV-1 escapes from N332-directed antibody neutralization in an elite neutralizer by envelope glycoprotein elongation and introduction of unusual disulfide bonds Retrovirology 2016;13 (1):48 [PubMed]
  • McCoy Laura E., van Gils Marit J., Ozorowski Gabriel, Messmer Terrence, Briney Bryan, Voss James E., Kulp Daniel W., Macauley Matthew S., Sok Devin, Pauthner Matthias, Menis Sergey, Cottrell Christopher A., Torres Jonathan L., Hsueh Jessica, Schief William R., Wilson Ian A., Ward Andrew B., Sanders Rogier W., Burton Dennis R. Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies Cell reports 2016;16 (9):2327-2338 [PubMed]
  • van den Kerkhof Tom L. G. M., van Gils Marit J., Boeser-Nunnink Brigitte D., Burger Judith A., Schuitemaker Hanneke, Sanders Rogier W. Probability of N332 glycan occupancy on HIV-1 gp120 modulates sensitivity to broadly neutralizing antibodies AIDS (London, England) 2016;30 (14):2179-2184 [PubMed]
  • Klasse P. J., LaBranche Celia C., Ketas Thomas J., Ozorowski Gabriel, Cupo Albert, Pugach Pavel, Ringe Rajesh P., Golabek Michael, van Gils Marit J., Guttman Miklos, Lee Kelly K., Wilson Ian A., Butera Salvatore T., Ward Andrew B., Montefiori David C., Sanders Rogier W., Moore John P. Sequential and Simultaneous Immunization of Rabbits with HIV-1 Envelope Glycoprotein SOSIP.664 Trimers from Clades A, B and C PLoS pathogens 2016;12 (9):e1005864 [PubMed]
  • Cornelissen Marion, Euler Zelda, van den Kerkhof Tom L. G. M., van Gils Marit J., Boeser-Nunnink Brigitte D. M., Kootstra Neeltje A., Zorgdrager Fokla, Schuitemaker Hanneke, Prins Jan M., Sanders Rogier W., van der Kuyl Antoinette C. The Neutralizing Antibody Response in an Individual with Triple HIV-1 Infection Remains Directed at the First Infecting Subtype AIDS research and human retroviruses 2016;32 (10-11):1135-1142 [PubMed]

2015

  • Sanders Rogier W., van Gils Marit J., Derking Ronald, Sok Devin, Ketas Thomas J., Burger Judith A., Ozorowski Gabriel, Cupo Albert, Simonich Cassandra, Goo Leslie, Arendt Heather, Kim Helen J., Lee Jeong Hyun, Pugach Pavel, Williams Melissa, Debnath Gargi, Moldt Brian, van Breemen Mariëlle J., Isik Gözde, Medina-Ramírez Max, Back Jaap Willem, Koff Wayne C., Julien Jean-Philippe, Rakasz Eva G., Seaman Michael S., Guttman Miklos, Lee Kelly K., Klasse Per Johan, Labranche Celia, Schief William R., Wilson Ian A., Overbaugh Julie, Burton Dennis R., Ward Andrew B., Montefiori David C., Dean Hansi, Moore John P. HIV-1 neutralizing antibodies induced by native-like envelope trimers Science 2015;349 (6244):aac4223-154 [PubMed]
  • Dosenovic Pia, von Boehmer Lotta, Escolano Amelia, Jardine Joseph, Freund Natalia T., Gitlin Alexander D., McGuire Andrew T., Kulp Daniel W., Oliveira Thiago, Scharf Louise, Pietzsch John, Gray Matthew D., Cupo Albert, van Gils Marit J., Yao Kai-Hui, Liu Cassie, Gazumyan Anna, Seaman Michael S., Björkman Pamela J., Sanders Rogier W., Moore John P., Stamatatos Leonidas, Schief William R., Nussenzweig Michel C. Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice Cell 2015;161 (7):1505-1515 [PubMed]
  • McCoy Laura E., Falkowska Emilia, Doores Katie J., Le Khoa, Sok Devin, van Gils Marit J., Euler Zelda, Burger Judith A., Seaman Michael S., Sanders Rogier W., Schuitemaker Hanneke, Poignard Pascal, Wrin Terri, Burton Dennis R. Incomplete Neutralization and Deviation from Sigmoidal Neutralization Curves for HIV Broadly Neutralizing Monoclonal Antibodies PLoS pathogens 2015;11 (8):e1005110 [PubMed]
  • Hu Joyce K., Crampton Jordan C., Cupo Albert, Ketas Thomas, van Gils Marit J., Sliepen Kwinten, de Taeye Steven W., Sok Devin, Ozorowski Gabriel, Deresa Isaiah, Stanfield Robyn, Ward Andrew B., Burton Dennis R., Klasse Per Johan, Sanders Rogier W., Moore John P., Crotty Shane Murine Antibody Responses to Cleaved Soluble HIV-1 Envelope Trimers Are Highly Restricted in Specificity Journal of virology 2015;89 (20):10383-10398 [PubMed]

2014

  • Huang Jinghe, Kang Byong H., Pancera Marie, Lee Jeong Hyun, Tong Tommy, Feng Yu, Imamichi Hiromi, Georgiev Ivelin S., Chuang Gwo-Yu, Druz Aliaksandr, Doria-Rose Nicole A., Laub Leo, Sliepen Kwinten, van Gils Marit J., de la Peña Alba Torrents, Derking Ronald, Klasse Per-Johan, Migueles Stephen A., Bailer Robert T., Alam Munir, Pugach Pavel, Haynes Barton F., Wyatt Richard T., Sanders Rogier W., Binley James M., Ward Andrew B., Mascola John R., Kwong Peter D., Connors Mark Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface Nature 2014;515 (7525):138-142 [PubMed]
  • Falkowska Emilia, Le Khoa M., Ramos Alejandra, Doores Katie J., Lee Jeong Hyun, Blattner Claudia, Ramirez Alejandro, Derking Ronald, van Gils Marit J., Liang Chi-Hui, McBride Ryan, von Bredow Benjamin, Shivatare Sachin S., Wu Chung-Yi, Chan-Hui Po-Ying, Liu Yan, Feizi Ten, Zwick Michael B., Koff Wayne C., Seaman Michael S., Swiderek Kristine, Moore John P., Evans David, Paulson James C., Wong Chi-Huey, Ward Andrew B., Wilson Ian A., Sanders Rogier W., Poignard Pascal, Burton Dennis R. Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers Immunity 2014;40 (5):657-668 [PubMed]
  • van den Kerkhof Tom L. G. M., Euler Zelda, van Gils Marit J., Boeser-Nunnink Brigitte D., Schuitemaker Hanneke, Sanders Rogier W. Early development of broadly reactive HIV-1 neutralizing activity in elite neutralizers AIDS (London, England) 2014;28 (8):1237-1240 [PubMed]
  • van Gils Marit J., Sanders Rogier W. In vivo protection by broadly neutralizing HIV antibodies Trends in microbiology 2014;22 (10):550-551 [PubMed]
  • Sok Devin, van Gils Marit J., Pauthner Matthias, Julien Jean-Philippe, Saye-Francisco Karen L., Hsueh Jessica, Briney Bryan, Lee Jeong Hyun, Le Khoa M., Lee Peter S., Hua Yuanzi, Seaman Michael S., Moore John P., Ward Andrew B., Wilson Ian A., Sanders Rogier W., Burton Dennis R. Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex Proceedings of the National Academy of Sciences of the United States of America 2014;111 (49):17624-17629 [PubMed]

2013

  • Sanders Rogier W., Derking Ronald, Cupo Albert, Julien Jean-Philippe, Yasmeen Anila, de Val Natalia, Kim Helen J., Blattner Claudia, de la Peña Alba Torrents, Korzun Jacob, Golabek Michael, de Los Reyes Kevin, Ketas Thomas J., van Gils Marit J., King C. Richter, Wilson Ian A., Ward Andrew B., Klasse P. J., Moore John P. A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies PLoS pathogens 2013;9 (9):e1003618 [PubMed]
  • van Gils Marit J., Sanders Rogier W. Broadly neutralizing antibodies against HIV-1: templates for a vaccine Virology 2013;435 (1):46-56 [PubMed]
  • Euler Zelda, van Gils Marit J., Boeser-Nunnink Brigitte D., Schuitemaker Hanneke, van Manen Daniëlle Genome-wide association study on the development of cross-reactive neutralizing antibodies in HIV-1 infected individuals PLoS ONE 2013;8 (1):e54684 [PubMed]
  • Malherbe Delphine C., Sanders Rogier W., van Gils Marit J., Park Byung, Gomes Michelle M., Schuitemaker Hanneke, Barnett Susan, Haigwood Nancy L. HIV-1 envelope glycoprotein resistance to monoclonal antibody 2G12 is subject-specific and context-dependent in macaques and humans PLoS ONE 2013;8 (9):e75277 [PubMed]
  • van den Kerkhof Tom L. G. M., Feenstra K. A., Euler Zelda, van Gils Marit J., Rijsdijk Linda W. E., Boeser-Nunnink Brigitte D., Heringa Jaap, Schuitemaker Hanneke, Sanders Rogier W. HIV-1 envelope glycoprotein signatures that correlate with the development of cross-reactive neutralizing activity Retrovirology 2013;10 (1) [PubMed]

2012

  • Euler Zelda, van den Kerkhof Tom L. G. M., van Gils Marit J., Burger Judith A., Edo-Matas Diana, Phung Pham, Wrin Terri, Schuitemaker Hanneke Longitudinal Analysis of Early HIV-1-Specific Neutralizing Activity in an Elite Neutralizer and in Five Patients Who Developed Cross-Reactive Neutralizing Activity Journal of virology 2012;86 (4):2045-2055 [PubMed]

2011

  • van Gils Marit J. Cross-rreactive neutralizing humoral immunity in HIV-1 disease: dynamics of host-pathogen interactions 2011. 263p. ISBN 9789490371692. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Schuitemaker H.)
  • van Gils Marit J., Edo-Matas Diana, Bowles Emma J., Burger Judith A., Stewart-Jones Guillaume B., Schuitemaker Hanneke Evolution of human immunodeficiency virus type 1 in a patient with cross-reactive neutralizing activity in serum Journal of virology 2011;85 (16):8443-8448 [PubMed]
  • van Gils Marit J., Bunnik Evelien M., Boeser-Nunnink Brigitte D., Burger Judith A., Terlouw-Klein Marijke, Verwer Naomi, Schuitemaker Hanneke Longer V1V2 region with increased number of potential N-linked glycosylation sites in the HIV-1 envelope glycoprotein protects against HIV-specific neutralizing antibodies Journal of virology 2011;85 (14):6986-6995 [PubMed]
  • Brinckmann Sarah, Da Costa Kelly, van Gils Marit J., Hallengärd David, Klein Katja, Madeira Luisa, Mainetti Lara, Palma Paolo, Raue Katharina, Reinhart David, Reudelsterz Marc, Ruffin Nicolas, Seifried Janna, Schäfer Katrein, Sheik-Khalil Enas, Sköld Annette, Uchtenhagen Hannes, Vabret Nicolas, Ziglio Serena, Scarlatti Gabriella, Shattock Robin, Wahren Britta, Gotch Frances Rational design of HIV vaccines and microbicides: report of the EUROPRISE network annual conference 2010 Journal of translational medicine 2011;9:40 [PubMed]

2010

  • van Gils Marit J., Schuitemaker Hanneke Correlations between HIV-1 clades and HIV-1 antibody neutralization sensitivity: significant for vaccine development? Current HIV research 2010;8 (8):579-586 [PubMed]
  • Euler Zelda, van Gils Marit J., Bunnik Evelien M., Phung Pham, Schweighardt Becky, Wrin Terri, Schuitemaker Hanneke Cross-Reactive Neutralizing Humoral Immunity Does Not Protect from HIV Type 1 Disease Progression Journal of infectious diseases 2010;201 (7):1045-1053 [PubMed]
  • Bunnik Evelien M., van Gils Marit J., Lobbrecht Marilie S. D., Pisas Linaida, Nanlohy Nening M., van Baarle Debbie, van Nuenen Ad C., Hessell Ann J., Schuitemaker Hanneke Emergence of monoclonal antibody b12-resistant human immunodeficiency virus type 1 variants during natural infection in the absence of humoral or cellular immune pressure Journal of general virology 2010;91 (Part 5):1354-1364 [PubMed]
  • Edo-Matas Diana, van Gils Marit J., Bowles Emma J., Navis Marjon, Rachinger Andrea, Boeser-Nunnink Brigitte, Stewart-Jones Guillaume B., Kootstra Neeltje A., Wout Angélique B. van 't, Schuitemaker Hanneke Genetic composition of replication competent clonal HIV-1 variants isolated from peripheral blood mononuclear cells (PBMC), HIV-1 proviral DNA from PBMC and HIV-1 RNA in serum in the course of HIV-1 infection Virology 2010;405 (2):492-504 [PubMed]
  • van Gils Marit J., Edo-Matas Diana, Schweighardt Becky, Wrin Terri, Schuitemaker Hanneke High prevalence of neutralizing activity against multiple unrelated human immunodeficiency virus type 1 (HIV-1) subtype B variants in sera from HIV-1 subtype B-infected individuals: evidence for subtype-specific rather than strain-specific neutralizing activity Journal of general virology 2010;91 (Part 1):250-258 [PubMed]
  • van Gils Marit J., Bunnik Evelien M., Burger Judith A., Jacob Yodit, Schweighardt Becky, Wrin Terri, Schuitemaker Hanneke Rapid Escape from Preserved Cross-Reactive Neutralizing Humoral Immunity without Loss of Viral Fitness in HIV-1-Infected Progressors and Long-Term Nonprogressors Journal of virology 2010;84 (7):3576-3585 [PubMed]
  • Wahren Britta, Biswas Priscilla, Borggren Marie, Coleman Adam, Da Costa Kelly, de Haes Winni, Dieltjens Tessa, Dispinseri Stefania, Grupping Katrijn, Hallengärd David, Hornig Julia, Klein Katja, Mainetti Lara, Palma Paolo, Reudelsterz Marc, Seifried Janna, Selhorst Philippe, Sköld Annette, Uchtenhagen Hannes, van Gils Marit J., Weber Caroline, Shattock Robin, Scarlatti Gabriella Rational design of HIV vaccine and microbicides: report of the EUROPRISE annual conference Journal of translational medicine 2010;8:72 [PubMed]
  • Wahren Britta, Biswas Priscilla, Borggren Marie, Coleman Adam, Da Costa Kelly, de Haes Winni, Dieltjens Tessa, Dispinseri Stefania, Grupping Katrijn, Hallengard David, Hornig Julia, Klein Katja, Mainetti Lara, Palma Paolo, Reudelsterz Marc, Seifried Janna, Selhorst Philippe, Skold Annette, Uchtenhagen Hannes, van Gils Marit J., Weber Caroline, Shattock Robin, Scarlatti Gabriella Rational design of HIV vaccine and microbicides: report of the EUROPRISE annual conference (vol 8, pg 82, 2010) Journal of translational medicine 2010;8:82

2009

  • Bunnik Evelien M., van Gils Marit J., Lobbrecht Marilie S. D., Pisas Linaida, van Nuenen Ad C., Schuitemaker Hanneke Changing sensitivity to broadly neutralizing antibodies b12, 2G12, 2F5, and 4E10 of primary subtype B human immunodeficiency virus type 1 variants in the natural course of infection Virology 2009;390 (2):348-355 [PubMed]
  • van Gils Marit J., Euler Zelda, Schweighardt Becky, Wrin Terri, Schuitemaker Hanneke Prevalence of cross-reactive HIV-1-neutralizing activity in HIV-1-infected patients with rapid or slow disease progression AIDS (London, England) 2009;23 (18):2405-2414 [PubMed]

2005

  • van de Bovenkamp Marja, Groothuis Geny M. M., Draaisma Annelies L., Merema Marjolijn T., Bezuijen Judith I., van Gils Marit J., Meijer Dirk K. F., Friedman Scott L., Olinga Peter Precision-cut liver slices as a new model to study toxicity-induced hepatic stellate cell activation in a physiologic milieu Toxicological sciences 2005;85 (1):632-638 [PubMed]
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