M.W. Veldkamp PhD publications

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Publications PhD M.W. Veldkamp

Position
Research Associate
Main activities
Education, Research
Specialisation
Cardiac Cellular Electrophysiology
Focus of research

Research is focused on elucidating the mechanisms underlying cardiac arrhythmias in which the regulation and (mal)function of ion channels, transporters and calcium-handling proteins plays a central role. Insight into arrhythmia mechanisms is achieved by studying electrical activity with the patch-clamp technique in various preparations including: isolated neonatal and adult cardiomyocytes, isolated intracardiac neurons, mammalian cell expression systems etc. Specific projects include:
- The cardiac sodium channel as part of a multi-molecular protein complex
- Differential expression and regulation of the cardiac sodium channels localized to different subcellular micro-domains of the cardiac myocyte
- Biophysical properties of cardiac and neuronal ion channel mutations associated with arrhythmia syndromes
- The role of the cardiac autonomous nervous system in atrial fibrillation: effects of neuropeptides on atrial electrophysiology
- Functional remodeling of intracardiac neurons in heart failure
 

2019

  • Casini Simona, Marchal Gerard A., Kawasaki Makiri, Nariswari Fransisca A., Portero Vincent, Guan Kaomei, Driessen Antoine H. G., Veldkamp Marieke W., Mengarelli Isabella, de Groot Joris R., Verkerk Arie O., Remme Carol Ann, van den Berg Nicoline W. E. Absence of Functional Nav1.8 Channels in Non-diseased Atrial and Ventricular Cardiomyocytes Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2019;33 (6):649-660 [PubMed]
  • Scherschel Katharina, Hedenus Katja, Jungen Christiane, Lemoine Marc D., Rübsamen Nicole, Veldkamp Marieke W., Klatt Niklas, Lindner Diana, Westermann Dirk, Casini Simona, Kuklik Pawel, Eickholt Christian, Klöcker Nikolaj, Shivkumar Kalyanam, Christ Torsten, Zeller Tanja, Willems Stephan, Meyer Christian Cardiac glial cells release neurotrophic S100B upon catheter-based treatment of atrial fibrillation Science translational medicine 2019;11 (493) [PubMed]

2018

  • Baartscheer Antonius, Veldkamp Marieke W. Is IGF-1 a useful inhibitor of Na+/H+-exchanger activity? Acta physiologica (Oxford, England) 2018;224 (2) [PubMed]
  • Veldkamp Marieke W., Geuzebroek Guillaume S. C., Baartscheer Antonius, Verkerk Arie O., Schumacher Cees A., Suarez Gedeon G., Berger Wouter R., Casini Simona, van Amersfoorth Shirley C. M., Scholman Koen T., Driessen Antoine H. G., Belterman Charly N. W., van Ginneken Antoni C. G., de Groot Joris R., de Bakker Jacques M. T., Remme Carol Ann, Boukens Bas J., Coronel Ruben Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel Nature communications 2018;9 (1) [PubMed]

2017

  • Portero Vincent, Casini Simona, Hoekstra Maaike, Verkerk Arie O., Mengarelli Isabella, Belardinelli Luiz, Rajamani Sridharan, Wilde Arthur A. M., Bezzina Connie R., Veldkamp Marieke W., Remme Carol Ann Anti-arrhythmic potential of the late sodium current inhibitor GS-458967 in murine Scn5a-1798insD+/- and human SCN5A-1795insD+/- iPSC-derived cardiomyocytes Cardiovascular research 2017;113 (7):829-838 [PubMed]
  • van den Berg N. W. E., Neefs J., Berger W. R., Baalman S. W. E., Meulendijks E., Kawasaki M., Kemper E. M., Piersma F. R., Veldkamp M. W., Wesselink R., Krul S. P. J., de Groot J. R. Can we spice up our Christmas dinner? Busting the myth of the 'Chinese restaurant syndrome' Netherlands heart journal 2017;25 (12):664-668 [PubMed]
  • Jungen Christiane, Scherschel Katharina, Eickholt Christian, Kuklik Pawel, Klatt Niklas, Bork Nadja, Salzbrunn Tim, Alken Fares, Angendohr Stephan, Klene Christiane, Mester Janos, Klöcker Nikolaj, Veldkamp Marieke W., Schumacher Udo, Willems Stephan, Nikolaev Viacheslav O., Meyer Christian Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias Nature communications 2017;8:14155 [PubMed]

2016

  • Baartscheer Antonius, Veldkamp Marieke W., Coronel Ruben Letter by Baartscheer et al Regarding Editorial, "Matter of Fat: Are Lipids Antiarrhythmic?" Circulation. Arrhythmia and electrophysiology 2016;9 (3):e003933 [PubMed]

2015

  • Baartscheer Antonius, Schumacher Cees A., Wekker Vincent, Verkerk Arie O., Veldkamp Marieke W., van Oort Ralph J., Elzenaar Ies, Ottenhoff Roelof, van Roomen Cindy, Aerts Hans, Coronel Ruben Dyscholesterolemia Protects Against Ischemia-Induced Ventricular Arrhythmias Circulation. Arrhythmia and electrophysiology 2015;8 (6):1481-1490 [PubMed]
  • Krul Sébastien P.J., Berger Wouter R., Veldkamp Marieke W., Driessen Antoine H.G., Wilde Arthur A.M., Deneke Thomas, De Bakker Jacques M.T., Coronel Ruben, De Groot Joris R. Treatment of Atrial and Ventricular Arrhythmias Through Autonomic Modulation JACC. Clinical electrophysiology 2015;1 (6):496-508

2013

  • Zumhagen Sven, Veldkamp Marieke W., Stallmeyer Birgit, Baartscheer Antonius, Eckardt Lars, Paul Matthias, Remme Carol Ann, Bhuiyan Zahurul A., Bezzina Connie R., Schulze-Bahr Eric A heterozygous deletion mutation in the cardiac sodium channel gene SCN5A with loss- and gain-of-function characteristics manifests as isolated conduction disease, without signs of Brugada or long QT syndrome PLoS ONE 2013;8 (6):e67963 [PubMed]
  • Geuzebroek Guillaume S. C. Modulation of atrial fibrillation 2013. 175p. ISBN 9789494618226. [UvA Dissertations Online] University of Amsterdam. (Supervisor: de Bakker J. M. T.; Co-supervisors: Coronel R., Veldkamp M. W.)
  • den Haan A. Dénise, Veldkamp Marieke W., Bakker Diane, Boink Geert J. J., Janssen Rob B., de Bakker Jacques M. T., Tan Hanno L. Organ explant culture of neonatal rat ventricles: a new model to study gene and cell therapy PLoS ONE 2013;8 (3):e59290 [PubMed]

2012

  • Verkerk Arie O., Geuzebroek Guillaume S. C., Veldkamp Marieke W., Wilders Ronald Effects of acetylcholine and noradrenalin on action potentials of isolated rabbit sinoatrial and atrial myocytes Frontiers in physiology 2012;3:UNSP 174 [PubMed]
  • Verkerk Arie O., Remme Carol Ann, Schumacher Cees A., Scicluna Brendon P., Wolswinkel Rianne, de Jonge Berend, Bezzina Connie R., Veldkamp Marieke W. Functional Na(V)1.8 Channels in Intracardiac Neurons The Link Between SCN10A and Cardiac Electrophysiology Circulation research 2012;111 (3):333-343 [PubMed]

2010

  • Casini Simona, Tan Hanno L., Demirayak Ilker, Remme Carol Ann, Amin Ahmad S., Scicluna Brendon P., Chatyan Houssine, Ruijter Jan M., Bezzina Connie R., van Ginneken Antoni C. G., Veldkamp Marieke W. Tubulin polymerization modifies cardiac sodium channel expression and gating Cardiovascular research 2010;85 (4):691-700 [PubMed]

2009

  • Remme Carol Ann, Scicluna Brendon P., Verkerk Arie O., Amin Ahmad S., van Brunschot Sandra, Beekman Leander, Deneer Vera H. M., Chevalier Catherine, Oyama Fumitaka, Miyazaki Haruko, Nukina Nobuyuki, Wilders Ronald, Escande Denis, Houlgatte Remi, Wilde Arthur A. M., Tan Hanno L., Veldkamp Marieke W., de Bakker Jacques M. T., Bezzina Connie R. Genetically Determined Differences in Sodium Current Characteristics Modulate Conduction Disease Severity in Mice With Cardiac Sodium Channelopathy Circulation research 2009;104 (11):1283-U112 [PubMed]
  • Casini Simona, Verkerk Arie O., van Borren Marcel M. G. J., van Ginneken Antoni C. G., Veldkamp Marieke W., de Bakker Jacques M. T., Tan Hanno L. Intracellular calcium modulation of voltage-gated sodium channels in ventricular myocytes Cardiovascular research 2009;81 (1):72-81 [PubMed]
  • Remme C. A., Verkerk A. O., Hoogaars W. M. H., Aanhaanen W. T. J., Scicluna B. P., Annink C., van den Hoff M. J. B., Wilde A. A. M., van Veen T. A. B., Veldkamp M. W., de Bakker J. M. T., Christoffels V. M., Bezzina C. R. The cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium Basic research in cardiology 2009;104 (5):511-522 [PubMed]

2008

  • Casini Simona Sodium channel dysfunction in inherited and acquired cardiac diseases 2008. 200p. ISBN 9788860391001. [UvA Dissertations Online] University of Amsterdam. (Supervisor: de Bakker J. M. T.; Co-supervisors: Tan H. L., Veldkamp M. W.)

2007

  • Casini Simona, Tan Hanno L., Bhuiyan Zahurul A., Bezzina Connie R., Barnett Phil, Cerbai Elisabetta, Mugelli Alessandro, Wilde Arthur A. M., Veldkamp Marieke W. Characterization of a novel SCN5A mutation associated with Brugada syndrome reveals involvement of DIIIS4-S5 linker in slow inactivation Cardiovascular research 2007;76 (3):418-429 [PubMed]
  • Remme C. A., Verkerk A. O., Wilde A. A. M., Veldkamp M. W., de Bakker J. M. T., Bezzina C. R. Diversity in cardiac sodium channel disease phenotype in transgenic mice carrying a single SCN5A mutation Netherlands heart journal 2007;15 (6):235-238 [PubMed]

2006

  • Verkerk Arie O., van Ginneken Antoni C. G., Berecki Géza, den Ruijter Hester M., Schumacher Cees A., Veldkamp Marieke W., Baartscheer Antonius, Casini Simona, Opthof Tobias, Hovenier Robert, Fiolet Jan W. T., Zock Peter L., Coronel Ruben Incorporated sarcolemmal fish oil fatty acids shorten pig ventricular action potentials Cardiovascular research 2006;70 (3):509-520 [PubMed]
  • Coronel R., Casini S., Koopmann T. T., Verkerk A. O., de Groot J. R., Bezzina C. R., Veldkamp M. W., Linnenbank A. C., Tan H. L., Wilde A. A. M., de Bakker J. M. T., Wilms-Schopman F. J. G., Bhuiyan Z., van der Wal A. C., Brugada P. Letters regarding article by Coronel et al, "Right ventricular fibrosis and conduction delay in a patient with clinical signs of Brugada syndrome: A combined electrophysiological, genetic, histopathologic, and computational study" - Response Circulation 2006;113 (16):E726-E727
  • Remme Carol Ann, Verkerk Arie O., Nuyens Dieter, van Ginneken Antoni C. G., van Brunschot Sandra, Belterman Charly N. W., Wilders Ronald, van Roon Marian A., Tan Hanno L., Wilde Arthur A. M., Carmeliet Peter, de Bakker Jacques M. T., Veldkamp Marieke W., Bezzina Connie R. Overlap syndrome of cardiac sodium channel disease in mice carrying the equivalent mutation of human SCN5A-1795insD Circulation 2006;114 (24):2584-2594 [PubMed]

2005

  • Smits Jeroen P. P., Koopmann Tamara T., Wilders Ronald, Veldkamp Marieke W., Opthof Tobias, Bhuiyan Zahir A., Mannens Marcel M. A. M., Balser Jeffrey R., Tan Hanno L., Bezzina Connie R., Wilde Arthur A. M. A mutation in the human cardiac sodium channel (E161K) contributes to sick sinus syndrome, conduction disease and Brugada syndrome in two families Journal of molecular and cellular cardiology 2005;38 (6):969-981 [PubMed]
  • Verkerk Arie O., Wilders Ronald, Veldkamp Marieke W., de Geringel Wouter, Kirkels Johannes H., Tan Hanno L. Gender disparities in cardiac cellular electrophysiology and arrhythmia susceptibility in human failing ventricular myocytes International heart journal 2005;46 (6):1105-1118 [PubMed]
  • Berecki Géza, Zegers Jan G., Verkerk Arie O., Bhuiyan Zahurul A., de Jonge Berend, Veldkamp Marieke W., Wilders Ronald, van Ginneken Antoni C. G. HERG channel (dys)function revealed by dynamic action potential clamp technique Biophysical journal 2005;88 (1):566-578 [PubMed]
  • Smits Jeroen P. P., Veldkamp Marieke W., Wilde Arthur A. M. Mechanisms of inherited cardiac conduction disease Europace : European pacing, arrhythmias, and cardiac electrophysiology 2005;7 (2):122-137 [PubMed]
  • Coronel Ruben, Casini Simona, Koopmann Tamara T., Wilms-Schopman Francien J. G., Verkerk Arie O., de Groot Joris R., Bhuiyan Zahurul, Bezzina Connie R., Veldkamp Marieke W., Linnenbank André C., van der Wal Allard C., Tan Hanno L., Brugada Pedro, Wilde Arthur A. M., de Bakker Jacques M. T. Right ventricular fibrosis and conduction delay in a patient with clinical signs of Brugada syndrome - A combined electrophysiological, genetic, histopathologic, and computational study Circulation 2005;112 (18):2769-2777 [PubMed]
  • Opthof T., Veldkamp M. W., Wilders R., van der Heyden M. A. G., Taggart P., Coronel R. Role of the autonomic nervous systemin: N. M. van Hemel, F. E. E. Vermeulen, J. M. T. de Bakker, editors. Exclusion or Targetting?. Nieuwegein: Grafische Producties Budde-Elinkwijk; 2005. p. 71-84, ISBN 9789090191843
  • Smits Jeroen P. P., Veldkamp Marieke W., Bezzina Connie R., Bhuiyan Zahir A., Wedekind Horst, Schulze-Bahr Eric, Wilde Arthur A. M. Substitution of a conserved alanine in the domain IIIS4-S5 linker of the cardiac sodium channel causes long QT syndrome Cardiovascular research 2005;67 (3):459-466 [PubMed]

2004

  • Smits J. P. P. The clinical and electrophysiological spectrum of cardiac sodium channel mutations 2004. 220p. ISBN 9789090181646. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Wilde A. A. M., Jongsma H. J.; Co-supervisor: Veldkamp M. W.)

2003

  • Wilders R., Veldkamp M. W., Baartscheer A., Zegers J. G., Bezzina C. R., Wilde A. A. M. Bradycardia in LQT3 patients: Insights from 0D modelsin: A. Anonymous, editors. Engineering in Medicine and Biology Society, 2003. S.l.: s.n.; 2003. p. 32-35, ISBN 9780780377899
  • Veldkamp Marieke W., Wilders Ronald, Baartscheer Antonius, Zegers Jan G., Bezzina Connie R., Wilde Arthur A. M. Contribution of sodium channel mutations to bradycardia and sinus node dysfunction in LQT3 families Circulation research 2003;92 (9):976-983 [PubMed]

2002

  • van den Berg M. P., Viersma J. W., Beaufort-Krol G. C. M., Bink-Boelkens M. Th E., Bezzina C. R., Veldkamp M. W., Brouwer J., Haaksma J., van Tintelen J. P., van Langen I. M., Wouda A. A., Wilde A. A. M. A large family characterised by nocturnal sudden death Netherlands heart journal 2002;10 (7-8):304-312 [PubMed]

2001

  • Wedekind H., Smits J. P., Schulze-Bahr E., Arnold R., Veldkamp M. W., Bajanowski T., Borggrefe M., Brinkmann B., Warnecke I., Funke H., Bhuiyan Z. A., Wilde A. A., Breithardt G., Haverkamp W. De novo mutation in the SCN5A gene associated with early onset of sudden infant death Circulation 2001;104 (10):1158-1164 [PubMed]
  • Verkerk A. O., Veldkamp M. W., Coronel R., Wilders R., van Ginneken A. C. Effects of cell-to-cell uncoupling and catecholamines on Purkinje and ventricular action potentials: implications for phase-1b arrhythmias Cardiovascular research 2001;51 (1):30-40 [PubMed]
  • Verkerk A. O., Veldkamp M. W., Baartscheer A., Schumacher C. A., Klöpping C., van Ginneken A. C., Ravesloot J. H. Ionic mechanism of delayed afterdepolarizations in ventricular cells isolated from human end-stage failing hearts Circulation 2001;104 (22):2728-2733 [PubMed]
  • Veldkamp M. W., Verkerk A. O., van Ginneken A. C., Baartscheer A., Schumacher C., de Jonge N., de Bakker J. M., Opthof T. Norepinephrine induces action potential prolongation and early afterdepolarizations in ventricular myocytes isolated from human end-stage failing hearts European heart journal 2001;22 (11):955-963 [PubMed]
  • Verkerk A. O., Schumacher C. A., van Ginneken A. C., Veldkamp M. W., Ravesloot J. H. Role of Ca(2+)-activated Cl(-) current in ventricular action potentials of sheep during adrenoceptor stimulation Experimental physiology 2001;86 (2):151-159 [PubMed]

2000

  • Verkerk A. O., Veldkamp M. W., Bouman L. N., van Ginneken A. C. Calcium-activated Cl(-) current contributes to delayed afterdepolarizations in single Purkinje and ventricular myocytes Circulation 2000;101 (22):2639-2644 [PubMed]
  • Veldkamp M. W. Decrease of delayed rectifier currents in the subacute phase of infarction Cardiovascular research 2000;48 (1):11-12 [PubMed]
  • Verkerk A. O., Veldkamp M. W., de Jonge N., Wilders R., van Ginneken A. C. Injury current modulates afterdepolarizations in single human ventricular cells Cardiovascular research 2000;47 (1):124-132 [PubMed]
  • Veldkamp M. W., Viswanathan P. C., Bezzina C., Baartscheer A., Wilde A. A., Balser J. R. Two distinct congenital arrhythmias evoked by a multidysfunctional Na(+) channel Circulation research 2000;86 (9):E91-E97 [PubMed]
  • Wilde A. A., Veldkamp M. W. What we can learn from individual resuscitated patients Cardiovascular research 2000;46 (1):14-16 [PubMed]

1999

  • Bezzina C., Veldkamp M. W., van den Berg M. P., Postma A. V., Rook M. B., Viersma J. W., van Langen I. M., Tan-Sindhunata G., Bink-Boelkens M. T., van der Hout A. H., Mannens M. M., Wilde A. A. A single Na(+) channel mutation causing both long-QT and Brugada syndromes Circulation research 1999;85 (12):1206-1213 [PubMed]
  • Veldkamp M. W., de Jonge B., van Ginneken A. C. Decreased inward rectifier current in adult rabbit ventricular myocytes maintained in primary culture: a single-channel study Cardiovascular research 1999;42 (2):424-433 [PubMed]
  • van Ginneken A. C., Veldkamp M. W. Implications of inhomogeneous distribution of IKS and IKr channels in ventricle with respect to effects of class III agents and beta-agonists Cardiovascular research 1999;43 (1):20-22 [PubMed]
  • Verkerk A. O., Veldkamp M. W., Abbate F., Antoons G., Bouman L. N., Ravesloot J. H., van Ginneken A. C. Two types of action potential configuration in single cardiac Purkinje cells of sheep American journal of physiology 1999;277 (4 Part 2):H1299-H1310 [PubMed]

1998

  • Veldkamp M. W. Is the slowly activating component of the delayed rectifier current, IKs' absent from undiseased human ventricular myocardium? Cardiovascular research 1998;40 (3):433-435 [PubMed]

1997

  • Coronel R., Opthof T., Taggart P., Tytgat J., Veldkamp M. Differential electrophysiology of repolarisation from clone to clinic Cardiovascular research 1997;33 (3):503-517 [PubMed]
  • Wilde A. A., Veldkamp M. W. Ion channels, the QT interval, and arrhythmias Pacing and clinical electrophysiology 1997;20 (8 Part 2):2048-2051 [PubMed]

1996

  • Verkerk A. O., Veldkamp M. W., van Ginneken A. C., Bouman L. N. Biphasic response of action potential duration to metabolic inhibition in rabbit and human ventricular myocytes: role of transient outward current and ATP-regulated potassium current Journal of molecular and cellular cardiology 1996;28 (12):2443-2456 [PubMed]

1995

  • Veldkamp M. W., van Ginneken A. C., Opthof T., Bouman L. N. Delayed rectifier channels in human ventricular myocytes Circulation 1995;92 (12):3497-3504 [PubMed]

1994

  • Veldkamp M. W., Vereecke J., Carmeliet E. Effects of intracellular sodium and hydrogen ion on the sodium activated potassium channel in isolated patches from guinea pig ventricular myocytes Cardiovascular research 1994;28 (7):1036-1041 [PubMed]
  • Wilde A. A., Veldkamp M. W., van Ginneken A. C., Opthof T. Phentolamine blocks ATP sensitive potassium channels in cardiac ventricular cells Cardiovascular research 1994;28 (6):847-850 [PubMed]

1993

  • Veldkamp M. W., van Ginneken A. C., Bouman L. N. Single delayed rectifier channels in the membrane of rabbit ventricular myocytes Circulation research 1993;72 (4):865-878 [PubMed]

1992

  • Veldkamp M. W., van Ginneken A. C. 2,4-Dinitrophenol induced outward current Cardiovascular research 1992;26 (11):1157-1158 [PubMed]