N.A.P. Franken PhD publications

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Publications PhD N.A.P. Franken

Position
Research Associate
Main activities
Education, Research, Other
Specialisation
Radiobiology
Focus of research

 

1)  Sensitization of radiotherapy by hyperthermia combined with chemotherapeutic agents. To increase effects radiation can be sensitized with hyperthermia and/or chemotherapy. In the laboratory these sensitization effects are investigated. Especially agents that inhibit or interfere with DNA damage repair are a main topic. In ther study hyperthermia is also combined with small molecules like PARP1 inhibitors and/or chemotherapeutic agents e.g. cisplatin to sensitize radiation treatment.

 

2)Radiation sensitization effects of hyperthermia. Hyperthermia is one of the best sensitizers of radiotherapy. Hyperthermia treatment of cancer is increasing the temperature of the tumor up to 41- 43 C. Radiotherapy (ionizing radiation) induces DNA lesions. The most severe lesions are DNA double strand breaks (DSB). These DSB are repaired by two major repair pathways, Non-Homologous end-joining (NHEJ) and Homologous Recombination repair (HR). Hyperthermia treatment of 1 h at 42 C can inhibit the HR repair via a transient degradation of the BRCA2 protein which one of the major proteins of this pathway. In the laboratory we investigate the biological effects of hyperthermia in in vitro cell cultures. One of the the research topics is the study of the DNA damage repair pathway. DNA repair proteins that accumulate at the sites of the DSB are studied with fluorescently labelled antibodies and studied with the fluorescence microscope.

3) Development of tests to predict normal tissue damage after Radiotherapy and/or Hyperthermia. Normal tissue damage after radiotherapy is a major problem in the clinic. Therefore in the lab special markers are investigated that can predict late normal tissue damage. n.a.franken@amc.uva.nl

 

2021

  • Löke Daan R., Helderman Roxan F. C. P. A., Rodermond Hans M., Tanis Pieter J., Streekstra Geert J., Franken Nicolaas A. P., Oei Arlene L., Crezee Johannes, Kok H. Petra Demonstration of treatment planning software for hyperthermic intraperitoneal chemotherapy in a rat model International journal of hyperthermia 2021;38 (1):38-54 [PubMed]
  • Löke Daan R., Helderman Roxan F. C. P. A., Franken Nicolaas A. P., Oei Arlene L., Tanis Pieter J., Crezee Johannes, Kok H. Petra Simulating drug penetration during hyperthermic intraperitoneal chemotherapy Drug delivery 2021;28 (1):145-161 [PubMed]

2020

  • Löke Daan R., Helderman Roxan F. C. P. A., Sijbrands Jan, Rodermond Hans M., Tanis Pieter J., Franken Nicolaas A. P., Oei Arlene L., Kok H. Petra, Crezee Johannes A four-inflow construction to ensure thermal stability and uniformity during hyperthermic intraperitoneal chemotherapy (HIPEC) in rats Cancers 2020;12 (12):1-14 [PubMed]
  • Agnass Pierre, Rodermond Hans M., Zweije Remko, Sijbrands Jan, Vogel Jantien A., van Lienden Krijn P., van Gulik Thomas M., van Veldhuisen Eran, Franken Nicolaas A. P., Oei Arlene L., Kok H. Petra, Besselink Marc G., Crezee Johannes Hycheed system for maintaining stable temperature control during preclinical irreversible electroporation experiments at clinically relevant temperature and pulse settings Sensors (Basel, Switzerland) 2020;20 (21):1-24 [PubMed]
  • Oei A. L., Kok H. P., Oei S. B., Horsman M. R., Stalpers L. J. A., Franken N. A. P., Crezee J. Molecular and biological rationale of hyperthermia as radio- and chemosensitizer Advanced drug delivery reviews 2020;163-164:84-97 [PubMed]
  • Mei Xionge, Cate Rosemarie Ten, van Leeuwen Caspar M., Rodermond Hans M., de Leeuw Lidewij, Dimitrakopoulou Dionysia, Stalpers Lukas J. A., Crezee Johannes, Kok H. Petra, Franken Nicolaas A. P., Oei Arlene L. Radiosensitization by hyperthermia: The effects of temperature, sequence, and time interval in cervical cell lines Cancers 2020;12 (3) [PubMed]
  • Crezee Johannes, Oei Arlene L., Franken Nicolaas A. P., Stalpers Lukas J. A., Kok H. Petra Response: Commentary: The Impact of the Time Interval Between Radiation and Hyperthermia on Clinical Outcome in Patients With Locally Advanced Cervical Cancer Frontiers in oncology 2020;10 [PubMed]
  • Helderman Roxan F. C. P. A., Löke Daan R., Verhoeff Jan, Rodermond Hans M., van Bochove Gregor G. W., Boon Menno, van Kesteren Sanne, Garcia Vallejo Juan J., Kok H. Petra, Tanis Pieter J., Franken Nicolaas A. P., Crezee Johannes, Oei Arlene L. The Temperature-Dependent Effectiveness of Platinum-Based Drugs Mitomycin-C and 5-FU during Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Colorectal Cancer Cell Lines Cells 2020;9 (8) [PubMed]

2019

  • Oei Arlene L., Korangath Preethi, Mulka Kathleen, Helenius Mikko, Coulter Jonathan B., Stewart Jacqueline, Velarde Esteban, Crezee Johannes, Simons Brian, Stalpers Lukas J. A., Kok H. Petra, Gabrielson Kathleen, Franken Nicolaas A. P., Ivkov Robert Enhancing the abscopal effect of radiation and immune checkpoint inhibitor therapies with magnetic nanoparticle hyperthermia in a model of metastatic breast cancer International journal of hyperthermia 2019;36:47-63 [PubMed]
  • Elming Pernille B., Sørensen Brita S., Oei Arlene L., Franken Nicolaas A.P., Crezee Johannes, Overgaard Jens, Horsman Michael R. Hyperthermia: The optimal treatment to overcome radiation resistant hypoxia Cancers 2019;11 (1) [PubMed]
  • Sharma Anirudh, Özayral Sanem, Caserto Julia S., ten Cate Rosemarie, Anders Nicole M., Barnett James D., Kandala Sri Kamal, Henderson Elizabeth, Stewart Jacqueline, Liapi Eleni, Rudek Michelle A., Franken Nicolaas A. P., Oei Arlene L., Korangath Preethi, Bunz Fred, Ivkov Robert Increased uptake of doxorubicin by cells undergoing heat stress does not explain its synergistic cytotoxicity with hyperthermia International journal of hyperthermia 2019;36 (1):712-720 [PubMed]
  • Kok H. Petra, van Dijk Irma W. E. M., Crama Koen F., Franken Nicolaas A. P., Rasch Coen R. N., Merks Johannes H. M., Crezee Johannes, Balgobind Brian V., Bel Arjan Re‑irradiation plus hyperthermia for recurrent pediatric sarcoma; a simulation study to investigate feasibility International journal of oncology 2019;54 (1):209-218 [PubMed]
  • Crezee Hans, Kok H. P., Oei Arlene L., Franken Nicolaas A. P., Stalpers Lukas J. A. The impact of the time interval between radiation and hyperthermia on clinical outcome in patients with locally advanced cervical cancer Frontiers in oncology 2019;9 (MAY) [PubMed]
  • Helderman Roxan F.C.P.A., Löke Daan R., Kok H. Petra, Oei Arlene L., Tanis Pieter J., Franken Nicolaas A.P.Klaas, Crezee Johannes Variation in clinical application of hyperthermic intraperitoneal chemotherapy: A review Cancers 2019;11 (1) [PubMed]

2018

  • Ijff Marloes, van Oorschot Bregje, Oei Arlene L., Krawczyk Przemek M., Rodermond Hans M., Stalpers Lukas J. A., Kok H. Petra, Crezee Johannes, Franken Nicolaas A. P. Enhancement of radiation effectiveness in cervical cancer cells by combining ionizing radiation with hyperthermia and molecular targeting agents International journal of molecular sciences 2018;19 (8) [PubMed]
  • Oei Arlene L., Ahire Vidhula R., van Leeuwen C. M., ten Cate Rosemarie, Stalpers Lukas J. A., Crezee Johannes, Kok H. Petra, Franken Nicolaas A. P. Enhancing radiosensitisation of BRCA2-proficient and BRCA2-deficient cell lines with hyperthermia and PARP1-i International journal of hyperthermia 2018;34 (1):39-48 [PubMed]
  • van Leeuwen C. M., Oei A. L., ten Cate R., Franken N. A. P., Bel A., Stalpers L. J. A., Crezee J., Kok H. P. Measurement and analysis of the impact of time-interval, temperature and radiation dose on tumour cell survival and its application in thermoradiotherapy plan evaluation International journal of hyperthermia 2018;34 (1):30-38 [PubMed]
  • Franken Nicolaas A. P., Stalpers Lukas J. A., Crezee Johannes Professor Gerrit Willem (Eddie) Barendsen, August 14, 1927 – June 20, 2018 International journal of radiation oncology, biology, physics 2018;102 (3):483-484 [PubMed]
  • van Leeuwen C. M., Oei A. L., Crezee J., Bel A., Franken N. A. P., Stalpers L. J. A., Kok H. P. The alfa and beta of tumours: A review of parameters of the linear-quadratic model, derived from clinical radiotherapy studies Radiation oncology (London, England) 2018;13 (1) [PubMed]
  • van der Horst Astrid, Versteijne Eva, Besselink Marc G. H., Daams Joost G., Bulle Esther B., Bijlsma Maarten F., Wilmink Johanna W., van Delden Otto M., van Hooft Jeanin E., Franken Nicolaas A. P., van Laarhoven Hanneke W. M., Crezee Johannes, van Tienhoven Geertjan The clinical benefit of hyperthermia in pancreatic cancer: a systematic review International journal of hyperthermia 2018;34 (7):969-979 [PubMed]
  • van Leeuwen C. M., Crezee J., Oei A. L., Franken N. A. P., Stalpers L. J. A., Bel A., Kok H. P. The effect of time interval between radiotherapy and hyperthermia on planned equivalent radiation dose International journal of hyperthermia 2018;34 (7):901-909 [PubMed]

2017

  • van Leeuwen C. M., Crezee J., Oei A. L., Franken N. A. P., Stalpers L. J. A., Bel A., Kok H. P. 3D radiobiological evaluation of combined radiotherapy and hyperthermia treatments International journal of hyperthermia 2017;33 (2):160-169 [PubMed]
  • van Leeuwen Caspar M., Oei Arlene L., Chin Kenneth W. T. K., Crezee Johannes, Bel Arjan, Westermann Anneke M., Buist Marrije R., Franken Nicolaas A. P., Stalpers Lukas J. A., Kok H. Petra A short time interval between radiotherapy and hyperthermia reduces in-field recurrence and mortality in women with advanced cervical cancer Radiation oncology (London, England) 2017;12 (1):75 [PubMed]
  • Vriend Lianne E. M., van den Tempel Nathalie, Oei Arlene L., L'Acosta Mike, Pieterson Frederique J., Franken Nicolaas A. P., Kanaar Roland, Krawczyk Przemek M. Boosting the effects of hyperthermia-based anticancer treatments by HSP90 inhibition Oncotarget 2017;8 (57):97490-97503 [PubMed]
  • Oei Arlene L., van Leeuwen Caspar M., Ahire Vidhula R., Rodermond Hans M., ten Cate Rosemarie, Westermann Anneke M., Stalpers Lukas J. A., Crezee Johannes, Kok H. Petra, Krawczyk Przemek M., Kanaar Roland, Franken Nicolaas A. P. Enhancing synthetic lethality of PARP-inhibitor and cisplatin in BRCA-proficient tumour cells with hyperthermia Oncotarget 2017;8 (17):28116-28124 [PubMed]
  • Franken Nicolaas A. Prof. Johan Broerse 1934-2017 Radiation research 2017;188 (5):595 [PubMed]
  • van Oorschot Bregje, Uitterhoeve Lon, Oomen Ilja, ten Cate Rosemarie, Medema Jan Paul, Vrieling Harry, Stalpers Lukas J. A., Moerland Perry D., Franken Nicolaas A. P. Prostate Cancer Patients with Late Radiation Toxicity Exhibit Reduced Expression of Genes Involved in DNA Double-Strand Break Repair and Homologous Recombination Cancer research 2017;77 (6):1485-1491 [PubMed]
  • Oei Arlene L., Vriend Lianne E. M., van Leeuwen Caspar M., Rodermond Hans M., ten Cate Rosemarie, Westermann Anneke M., Stalpers Lukas J. A., Crezee Johannes, Kanaar Roland, Kok H. Petra, Krawczyk Przemek M., Franken Nicolaas A. P. Sensitizing thermochemotherapy with a PARP1-inhibitor Oncotarget 2017;8 (10):16303-16312 [PubMed]
  • Oei A. L., Vriend L. E. M., Krawczyk P. M., Horsman M. R., Franken N. A. P., Crezee J. Targeting therapy-resistant cancer stem cells by hyperthermia International journal of hyperthermia 2017;33 (4):419-427 [PubMed]
  • Oei Arlene L. Tumor cells can’t stand the heat: Boosting the effectiveness of hyperthermia in cervical carcinoma 2017. 299p. ISBN 9789462955103. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Medema J. P., Stalpers L. J. A.; Co-supervisors: Franken N. A. P., Kok H. P.)

2016

  • Franken Nicolaas A. P., Kok H. Petra, Crezee Johannes, Barendsen Gerrit W. Analysis of enhancement at small and large radiation doses for effectiveness of inactivation in cultured cells by combining two agents with radiation International journal of radiation biology 2016;92 (9):521-526 [PubMed]
  • Crezee J., van Leeuwen C. M., Oei A. L., van Heerden L. E., Bel A., Stalpers L. J. A., Ghadjar P., Franken N. A. P., Kok H. P. Biological modelling of the radiation dose escalation effect of regional hyperthermia in cervical cancer Radiation oncology (London, England) 2016;11 (1):14 [PubMed]
  • Bergs Judith W. J., Oei Arlene L., ten Cate Rosemarie, Rodermond Hans M., Stalpers Lukas J., Barendsen Gerrit W., Franken Nicolaas A. P. Dynamics of chromosomal aberrations, induction of apoptosis, BRCA2 degradation and sensitization to radiation by hyperthermia International journal of molecular medicine 2016;38 (1):243-250 [PubMed]
  • van Oorschot Bregje, Hovingh Suzanne, Dekker Annelot, Stalpers Lukas J., Franken Nicolaas A. P. Predicting Radiosensitivity with Gamma-H2AX Foci Assay after Single High-Dose-Rate and Pulsed Dose-Rate Ionizing Irradiation Radiation research 2016;185 (2):190-198 [PubMed]
  • van Oorschot Bregje, Granata Giovanna, Di Franco Simone, ten Cate Rosemarie, Rodermond Hans M., Todaro Matilde, Medema Jan Paul, Franken Nicolaas A. P. Targeting DNA double strand break repair with hyperthermia and DNA-PKcs inhibition to enhance the effect of radiation treatment Oncotarget 2016;7 (40):65504-65513 [PubMed]
  • Crezee Hans, van Leeuwen Caspar M., Oei Arlene L., Stalpers Lukas J. A., Bel Arjan, Franken Nicolaas A., Kok H. Petra Thermoradiotherapy planning: Integration in routine clinical practice International journal of hyperthermia 2016;32 (1):41-49 [PubMed]
  • van Oorschot Bregje Tumor control and normal tissue toxicity: The two faces of radiotherapy 2016. 165p. ISBN 9789461827104. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Medema J. P., Stalpers L. J. A.; Co-supervisors: Franken N. A. P., Vrieling H.)

2015

  • Oei Arlene L., Vriend Lianne E. M., Crezee Johannes, Franken Nicolaas A. P., Krawczyk Przemek M. Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all Radiation oncology (London, England) 2015;10:165 [PubMed]
  • Oei Arlene L., van Leeuwen Caspar M., ten Cate Rosemarie, Rodermond Hans M., Buist Marrije R., Stalpers Lukas J. A., Crezee Johannes, Kok H. Petra, Medema Jan Paul, Franken Nicolaas A. P. Hyperthermia Selectively Targets Human Papillomavirus in Cervical Tumors via p53-Dependent Apoptosis Cancer research 2015;75 (23):5120-5129 [PubMed]

2014

  • van Oorschot Bregje, Oei Arlene L., Nuijens Anna C., Rodermond Hans, Hoeben Ron, Stap Jan, Stalpers Lukas J., Franken Nicolaas A. P. Decay of γ-H2AX foci correlates with potentially lethal damage repair and P53 status in human colorectal carcinoma cells Cellular & molecular biology letters 2014;19 (1):37-51 [PubMed]
  • Franken Nicolaas A. P., Barendsen Gerrit W. Enhancement of radiation effectiveness by hyperthermia and incorporation of halogenated pyrimidines at low radiation doses as compared with high doses: implications for mechanisms International journal of radiation biology 2014;90 (4):313-317 [PubMed]
  • Kok H. Petra, Crezee Johannes, Franken Nicolaas A. P., Stalpers Lukas J. A., Barendsen Gerrit W., Bel Arjan Quantifying the combined effect of radiation therapy and hyperthermia in terms of equivalent dose distributions International journal of radiation oncology, biology, physics 2014;88 (3):739-745 [PubMed]
  • van Oorschot Bregje, Hovingh Suzanne E., Moerland Perry D., Medema Jan Paul, Stalpers Lukas J. A., Vrieling Harry, Franken Nicolaas A. P. Reduced activity of double-strand break repair genes in prostate cancer patients with late normal tissue radiation toxicity International journal of radiation oncology, biology, physics 2014;88 (3):664-670 [PubMed]
  • van Dijk Irma W. E. M., van Os Rob M., van de Kamer Jeroen B., Franken Nicolaas A. P., van der Pal Helena J. H., Koning Caro C. E., Caron Huib N., Ronckers Cécile M., Kremer Leontien C. M. The use of equivalent radiation dose in the evaluation of late effects after childhood cancer treatment Journal of cancer survivorship 2014;8 (4):638-646 [PubMed]

2013

  • Franken Nicolaas A. P., Oei Arlene L., Kok H. Petra, Rodermond Hans M., Sminia Peter, Crezee Johannes, Stalpers Lukas J. A., Barendsen Gerrit W. Cell survival and radiosensitisation: modulation of the linear and quadratic parameters of the LQ model (Review) International journal of oncology 2013;42 (5):1501-1515 [PubMed]
  • van Oorschot Bregje, Hovingh Suzanne E., Rodermond Hans, Güçlü Ahmed, Losekoot Nienke, Geldof Albert A., Barendsen Gerrit W., Stalpers Lukas J., Franken Nicolaas A. P. Decay of γ-H2AX foci correlates with potentially lethal damage repair in prostate cancer cells Oncology reports 2013;29 (6):2175-2180 [PubMed]
  • Bergs Judith W. J., Krawczyk Przemek M., Borovski Tijana, ten Cate Rosemarie, Rodermond Hans M., Stap Jan, Medema Jan Paul, Haveman Jaap, Essers Jeroen, van Bree Chris, Stalpers Lukas J. A., Kanaar Roland, Aten Jacob A., Franken Nicolaas A. P. Inhibition of homologous recombination by hyperthermia shunts early double strand break repair to non-homologous end-joining DNA repair 2013;12 (1):38-45 [PubMed]
  • Franken N. A. P., Barendsen G. W. In regard to Ohri N et al International journal of radiation oncology, biology, physics 2013;86 (4):598 [PubMed]

2012

  • Borovski Tijana Cancer stem cell niche: the place to be 2012. 157p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Medema Jan P.; Co-supervisors: Sprick M. R., Franken N. A. P.)
  • Krawczyk P. M., Borovski T., Stap J., Cijsouw T., ten Cate R., Medema J. P., Kanaar R., Franken N. A. P., Aten J. A. Chromatin mobility is increased at sites of DNA double-strand breaks Journal of cell science 2012;125 (9):2127-2133 [PubMed]
  • Eppink Berina, Stalpers Lukas, Kanaar Roland, Franken Nicolaas A. P. Hyperthermie Kanker Breed 2012;4 (4):21-24
  • Stalpers Lukas J. A., van Dullemen Simon, Franken N. A. P. Klaas Medische en biologische gevolgen van kernrampen: medische stralingsrisico's overdreven; psychologische risico's onderschat Nederlands tijdschrift voor geneeskunde 2012;156 (20):A4394 [PubMed]
  • Stalpers Lukas, Franken Klaas Radiobiologie: 30 jaar lineair-kwadratisch model Nederlands tijdschrift voor geneeskunde 2012;156:A4670
  • Franken Nicolaas A. P., Hovingh Suzanne, ten Cate Rosemarie, Krawczyk Przemek, Stap Jan, Hoebe Ron, Aten Jacob, Barendsen Gerrit W. Relative biological effectiveness of high linear energy transfer alpha-particles for the induction of DNA-double-strand breaks, chromosome aberrations and reproductive cell death in SW-1573 lung tumour cells Oncology reports 2012;27 (3):769-774 [PubMed]

2011

  • Franken Nicolaas A. P., ten Cate Rosemarie, Krawczyk Przemek M., Stap Jan, Haveman Jaap, Aten Jacob, Barendsen Gerrit W. Comparison of RBE values of high-LET α-particles for the induction of DNA-DSBs, chromosome aberrations and cell reproductive death Radiation oncology (London, England) 2011;6 (1):64 [PubMed]
  • Krawczyk Przemek M., Eppink Berina, Essers Jeroen, Stap Jan, Rodermond Hans, Odijk Hanny, Zelensky Alex, van Bree Chris, Stalpers Lukas J., Buist Marrije R., Soullié Thomas, Rens Joost, Verhagen Hence J. M., O'Connor Mark J., Franken Nicolaas A. P., ten Hagen Timo L. M., Kanaar Roland, Aten Jacob A. Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition Proceedings of the National Academy of Sciences of the United States of America 2011;108 (24):9851-9856 [PubMed]

2010

  • Rodermond Hans M., ten Cate Rosemarie, Haveman Jaap, van Kuilenburg Andre, Medema Jan Paul, van Bree Chris, Franken Nicolaas A. P. Cyclopentenylcytosine does not enhance cisplatin-induced radiosensitization in human lung tumour cells Oncology letters 2010;1 (3):537-540 [PubMed]
  • Darroudi Firouz, Bergs Judith W. J., Bezrookove Vladimir, Buist Marrije R., Stalpers Lukas J., Franken Nicolaas A. P. PCC and COBRA-FISH a new tool to characterize primary cervical carcinomas: to assess hall-marks and stage specificity Cancer letters 2010;287 (1):67-74 [PubMed]
  • ten Cate Rosemarie, Krawczyk Przemek M., Stap Jan, Aten Jacob A., Franken Nicolaas A. P. Radiosensitizing effect of the histone acetyltransferase inhibitor anacardic acid on various mammalian cell lines Oncology letters 2010;1 (4):765-769 [PubMed]

2009

  • Crezee Johannes, Barendsen Gerrit W., Westermann Anneke M., Hulshof Maarten C. C. M., Haveman Jaap, Stalpers Lukas J. A., Geijsen E. Debby, Franken Nicolaas A. P. QUANTIFICATION OF THE CONTRIBUTION OF HYPERTHERMIA TO RESULTS OF CERVICAL CANCER TRIALS: IN REGARD TO PLATANIOTIS AND DALE (INT J RADIAT ONCOL BIOL PHYS 2009;73:1538-1544) International journal of radiation oncology, biology, physics 2009;75 (2):634 [PubMed]
  • Bergs J. W. J., ten Cate R., Rodermond H. M., Jaarsma P. A., Medema J. P., Darroudi F., Buist M. R., Stalpers L. J. A., Haveman J., van Bree C., Franken N. A. P. Transient inhibition of Calyculin A induced premature chromosome condensation by hyperthermia International journal of hyperthermia 2009;25 (3):220-228 [PubMed]

2008

  • Bergs J. W. J., ten Cate R., Haveman J., Medema J. P., Franken N. A. P., van Bree C. Chromosome Fragments have the Potential to Predict Hyperthermia-induced Radio-sensitization in Two Different Human Tumor Cell Lines Journal of radiation research 2008;49 (5):465-472 [PubMed]
  • van Bree Chris, Rodermond Hans M., ten Cate Rosemarie, de Vos Judith, Stalpers Lukas J. A., Haveman Jaap, Medema Jan Paul, Franken Nicolaas A. P. G0 cell cycle arrest alone is insufficient for enabling the repair of ionizing radiation-induced potentially lethal damage Radiation research 2008;170 (2):184-191 [PubMed]

2007

  • Bergs Judith W. J., Haveman Jaap, ten Cate Rosemarie, Medema Jan Paul, Franken Nicolaas A. P., van Bree Chris Effect of 41 degrees C and 43 degrees C on cisplatin radiosensitization in two human carcinoma cell lines with different sensitivities for cisplatin Oncology reports 2007;18 (1):219-226 [PubMed]
  • Bergs J. W. J., Franken N. A. P., Haveman J., Geijsen E. D., Crezee J., van Bree C. Hyperthermia, cisplatin and radiation trimodality treatment: a promising cancer treatment? A review from preclinical studies to clinical application International journal of hyperthermia 2007;23 (4):329-341 [PubMed]
  • Bergs Judith W. J. Hyperthermia, cisplatin and radiation trimodality treatment: In vitro studies on interaction mechanisms 2007. 190p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Koning Caro C. E.; Co-supervisor: Franken N. A. P.)
  • Haveman Jaap, Rodermond Hans, van Bree Chris, Wondergem Jan, Franken Nicolaas A. P. Residual late radiation damage in mouse stromal tissue assessed by the tumor bed effect Journal of radiation research 2007;48 (2):107-112 [PubMed]

2006

  • Svensson J. Peter, Stalpers Lukas J. A., Esveldt-van Lange Rebecca E. E., Franken Nicolaas A. P., Haveman Jaap, Klein Binie, Turesson Ingela, Vrieling Harry, Giphart-Gassler Micheline Analysis of gene expression using gene sets discriminates cancer patients with and without late radiation toxicity PLoS medicine 2006;3 (10):e422-1914 [PubMed]
  • Franken Nicolaas A. P., Rodermond Hans M., Stap Jan, Haveman Jaap, van Bree Chris Clonogenic assay of cells in vitro Nature protocols 2006;1 (5):2315-2319 [PubMed]
  • Bergs J. W. J., Franken N. A. P., ten Cate R., van Bree C., Haveman J. Effects of cisplatin and gamma-irradiation on cell survival, the induction of chromosomal aberrations and apoptosis in SW-1573 cells Mutation research 2006;594 (1-2):148-154 [PubMed]
  • Sigmond J., Haveman J., Kreder N. Castro, Loves W. J., van Bree C., Franken N. A., Peters G. J. Enhanced activity of deoxycytidine kinase after pulsed low dose rate and single dose gamma irradiation Nucleosides, nucleotides & nucleic acids 2006;25 (9-11):1177-1180 [PubMed]
  • Franken N. A. P., Bergs J. W. J., Kok T. T., Kuperus R. R. N., Stecher-Rasmussen F., Haveman J., van Bree C., Stalpers L. J. A. Gadolinium enhances the sensitivity of SW-1573 cells for thermal neutron irradiation Oncology reports 2006;15 (3):715-720 [PubMed]
  • Haveman J., Sigmond J., van Bree C., Franken N. A., Koedooder C., Peters G. J. Time course of enhanced activity of deoxycytidine kinase and thymidine kinase 1 and 2 in cultured human squamous lung carcinoma cells, SW-1573, induced by gamma-irradiation Oncology reports 2006;16 (4):901-905 [PubMed]

2005

  • Haveman J., Bergs J. W. J., Franken N. A. P., van Bree C., Stalpers L. J. A. Effect of hyperthermia on uptake and cytotoxicity of cisplatin in cultured murine mammary carcinoma cells Oncology reports 2005;14 (2):561-567 [PubMed]
  • van Bree Chris, Rodermond Hans M., de Vos Judith, Haveman Jaap, Franken Nicolaas A. P. Mismatch repair proficiency is not required for radioenhancement by gemcitabine International journal of radiation oncology, biology, physics 2005;62 (5):1504-1509 [PubMed]

2004

  • Haveman J., Castro Kreder N., Rodermond H. M., van Bree C., Franken N. A. P., Stalpers L. J. A., Zdzienicka M. Z., Peters G. J. Cellular response of X-ray sensitive hamster mutant cell lines to gemcitabine, cisplatin and 5-fluorouracil Oncology reports 2004;12 (1):187-192 [PubMed]
  • Kreder N. Castro, ten Cate R., Rodermond H. M., van Bree C., Franken N. A. P., Zdzienicka M. Z., Haveman J. Cellular response to pulsed low-dose rate irradiation in X-ray sensitive hamster mutant cell lines Journal of radiation research 2004;45 (3):385-391 [PubMed]
  • Franken N. A. P., van Bree C., Haveman J. Differential response to radiation of TP53-inactivated cells by overexpression of dominant-negative mutant TP53 or HPVE6 Radiation research 2004;161 (5):504-510 [PubMed]
  • Castro Kreder Natasja, van Bree Chris, Franken Nicolaas A. P., Haveman Jaap Effects of gemcitabine on cell survival and chromosome aberrations after pulsed low dose-rate irradiation Journal of radiation research 2004;45 (1):111-118 [PubMed]
  • Franken Nicolaas A. P., ten Cate Rosemarie, van Bree Chris, Haveman Jaap Induction of the early response protein EGR-1 in human tumour cells after ionizing radiation is correlated with a reduction of repair of lethal lesions and an increase of repair of sublethal lesions International journal of oncology 2004;24 (4):1027-1031 [PubMed]
  • van Bree C., Franken N. A. P., Rodermond H. M., Stalpers L. J. A., Haveman J. Repair of potentially lethal damage does not depend on functional TP53 in human glioblastoma cells Radiation research 2004;161 (5):511-516 [PubMed]

2003

  • Castro Kreder Natasja, van Bree Chris, Franken Nicolaas A. P., Haveman Jaap Colour junctions as predictors of radiosensitivity: X-irradiation combined with gemcitabine in a lung carcinoma cell line Journal of cancer research and clinical oncology 2003;129 (10):597-603 [PubMed]

2002

  • Castro Kreder N., van Bree C., Franken N. A. P., Haveman J. Chromosome aberrations detected by FISH and correlation with cell survival after irradiation at various dose-rates and after bromodeoxyuridine radiosensitization International journal of radiation biology 2002;78 (3):203-210 [PubMed]
  • Franken N. A. P., van Bree C., ten Cate R., van Oven C. H., Haveman J. Importance of TP53 and RB in the repair of potentially lethal damage and induction of color junctions after exposure to ionizing radiation Radiation research 2002;158 (6):707-714 [PubMed]
  • Ludwików G., Xiao Yun, Hoebe R. A., Franken N. A. P., Darroudi F., Stap J., van Oven C. H., van Noorden C. J. F., Aten J. A. Induction of chromosome aberrations in unirradiated chromatin after partial irradiation of a cell nucleus International journal of radiation biology 2002;78 (4):239-247 [PubMed]
  • van Bree Chris, Castro Kreder Natasja, Loves Willem J. P., Franken Nicolaas A. P., Peters Godefridus J., Haveman Jaap Sensitivity to ionizing radiation and chemotherapeutic agents in gemcitabine-resistant human tumor cell lines International journal of radiation oncology, biology, physics 2002;54 (1):237-244 [PubMed]

2001

  • Barendsen G. W., van Bree C., Franken N. A. Importance of cell proliferative state and potentially lethal damage repair on radiation effectiveness: implications for combined tumor treatments (review) International journal of oncology 2001;19 (2):247-256 [PubMed]
  • Persons C. C., Hermens A. F., Franken N. A., Wondergem J. Muscle wasting after radiotherapy in young and adult rats Oncology reports 2001;8 (5):1117-1122 [PubMed]
  • Franken N. A., van Bree C., Veltmaat M. A., Rodermond H. M., Haveman J., Barendsen G. W. Radiosensitization by bromodeoxyuridine and hyperthermia: analysis of linear and quadratic parameters of radiation survival curves of two human tumor cell lines Journal of radiation research 2001;42 (2):179-190 [PubMed]
  • van Bree C., Franken N. A., Snel F. A., Haveman J., Bakker P. J. Wild-type p53-function is not required for hyperthermia-enhanced cytotoxicity of cisplatin International journal of hyperthermia 2001;17 (4):337-346 [PubMed]

2000

  • Ludwików G., Hoebe R. A., Franken N. A., van Oven C. H., Stap J., Aten J. A. A method for the selective irradiation of part of a genome Acta oncologica (Stockholm, Sweden) 2000;39 (6):693-698 [PubMed]
  • Franken N. A., van Bree C., Kipp J. B., Rodermond H. M., Haveman J., Barendsen G. W. BrdUrd-induced radiosensitization of two human tumour cell lines at iso-levels of incorporation Oncology reports 2000;7 (5):937-940 [PubMed]
  • Franken N. A., Strootman E., Hollaar L., van der Laarse A., Wondergem J. Myocardial enzyme activities in plasma after whole-heart irradiation in rats Journal of cancer research and clinical oncology 2000;126 (1):27-32 [PubMed]
  • van Bree C., Savonije J. H., Franken N. A., Haveman J., Bakker P. J. The effect of p53-function on the sensitivity to paclitaxel with or without hyperthermia in human colorectal carcinoma cells International journal of oncology 2000;16 (4):739-744 [PubMed]

1999

  • Franken N. A., Ruurs P., Ludwików G., van Bree C., Kipp J. B., Darroudi F., Barendsen G. W. Correlation between cell reproductive death and chromosome aberrations assessed by FISH for low and high doses of radiation and sensitization by iodo-deoxyuridine in human SW-1573 cells International journal of radiation biology 1999;75 (3):293-299 [PubMed]
  • van Bree C., van der Maat B., Ceha H. M., Franken N. A., Haveman J., Bakker P. J. Inactivation of p53 and of pRb protects human colorectal carcinoma cells against hyperthermia-induced cytotoxicity and apoptosis Journal of cancer research and clinical oncology 1999;125 (10):549-555 [PubMed]
  • Franken N. A., van Bree C., Veltmaat M. A., Ludwików G., Kipp J. B., Barendsen G. W. Increased chromosome exchange frequencies in iodo-deoxyuridine-sensitized human SW-1573 cells after gamma-irradiation Oncology reports 1999;6 (1):59-63 [PubMed]

1998

  • Wondergem J., Franken N. A., Chin A., van Ravels F. J., Leer J. W. Additive effect of concomitant multiple low-dose doxorubicin and thoracic irradiation on ex vivo cardiac performance of the rat heart Journal of cancer research and clinical oncology 1998;124 (3-4):148-154 [PubMed]

1997

  • Franken N. A., Camps J. A., van Ravels F. J., van der Laarse A., Pauwels E. K., Wondergem J. Comparison of in vivo cardiac function with ex vivo cardiac performance of the rat heart after thoracic irradiation British journal of radiology 1997;70 (838):1004-1009 [PubMed]
  • van Bree C., Franken N. A., Bakker P. J., Klomp-Tukker L. J., Barendsen G. W., Kipp J. B. Hyperthermia and incorporation of halogenated pyrimidines: radiosensitization in cultured rodent and human tumor cells International journal of radiation oncology, biology, physics 1997;39 (2):489-496 [PubMed]
  • Franken N. A., van Bree C. V., Kipp J. B., Barendsen G. W. Modification of potentially lethal damage in irradiated Chinese hamster V79 cells after incorporation of halogenated pyrimidines International journal of radiation biology 1997;72 (1):101-109 [PubMed]
  • Franken N., Vanbree C., Streefkerk J., Kuper I., Rodermond H., Kipp J., Haveman J., Barendsen G. Radiosensitization by iodo-deoxyuridine in cultured SW-1573 human lung tumor cells Oncology reports 1997;4 (5):1073-1076 [PubMed]

1996

  • Wondergem J., Franken N. A., van der Laarse A., Persons C. C., van Ravels F. J., Reijnart I. C., Strootman E. G. Changes in cardiac performance and sympathetic stimulation during and after fractionated radiotherapy in a rat model Radiotherapy and oncology 1996;38 (1):33-40 [PubMed]
  • Persons C. C., Franken N. A., Wondergem J. Changes in myocardial and circulating atrial natriuretic peptide following thorax irradiation in rat International journal of radiation biology 1996;70 (1):61-68 [PubMed]

1995

  • Sminia P., Hendriks J. J., van der Kracht A. H., Rodermond H. M., Haveman J., Jansen W., Koedooder K., Franken N. A. Neurological observations after local irradiation and hyperthermia of rat lumbosacral spinal cord International journal of radiation oncology, biology, physics 1995;32 (1):165-174 [PubMed]
  • Le C. T., Hollaar L., van der Valk E. J., Franken N. A., van Ravels F. J., Wondergem J., van der Laarse A. Protection of myocytes against free radical-induced damage by accelerated turnover of the glutathione redox cycle European heart journal 1995;16 (4):553-562 [PubMed]

1993

  • Franken N. A., Hollaar L., Bosker F. J., van Ravels F. J., van der Laarse A., Wondergem J. Effects of in vivo heart irradiation on myocardial energy metabolism in rats Radiation research 1993;134 (1):79-85 [PubMed]

1992

  • Franken N. A., de Vrind H. H., Sminia P., Haveman J., Troost D., Gonzalez Gonzalez D. Neurological complications after 434 MHz microwave hyperthermia of the rat lumbar region including the spinal cord International journal of radiation biology 1992;62 (2):229-238 [PubMed]
  • Franken N. A., van der Laarse A., Bosker F. J., Reynart I. W., van Ravels F. J., Strootman E., Wondergem J. Time dependent changes in myocardial norepinephrine concentration and adrenergic receptor density following X-irradiation of the rat heart International journal of radiation oncology, biology, physics 1992;24 (4):721-727 [PubMed]

1986

  • Star W. M., Marijnissen H. P., van den Berg-Blok A. E., Versteeg J. A., Franken K. A., Reinhold H. S. Destruction of rat mammary tumor and normal tissue microcirculation by hematoporphyrin derivative photoradiation observed in vivo in sandwich observation chambers Cancer research 1986;46 (5):2532-2540 [PubMed]
  • Franken N. A., van Langevelde A., Pauwels E. K., Journée-de Korver J. G., Bakker C. N., Oosterhuis J. A. Radio-iodine-labelled 5-iodo-2-thiouracil: a potential radiopharmaceutical for establishing the viability of ocular melanoma after radiation therapy Nuclear medicine communications 1986;7 (11):797-809 [PubMed]
  • Franken N. A., van Delft J. L., van Langevelde A., Bleeker J. C., de Wolff-Rouendaal D., van Best J. A., Bouwhuis-Hoogerwerf M. L., Oosterhuis J. A., Pauwels E. K. Scintimetric detection of choroidal malignant melanoma with [123I]-5-iodo-2-thiouracil Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde 1986;193 (4):248-254 [PubMed]

1985

  • Franken K. A., van Delft J. L., Dubbelman T. M., de Wolff-Rouendaal D., Oosterhuis J. A., Star W. M., Marijnissen H. P. Hematoporphyrin derivative photoradiation treatment of experimental malignant melanoma in the anterior chamber of the rabbit Current eye research 1985;4 (5):641-654 [PubMed]
  • Franken N. A., van Langevelde A., Journée-de Korver J. G., Bakker C. N., Feitsma R. I., van Delft J. L., Oosterhuis J. A., Pauwels E. K. Uptake of 123I-5-iodo-2-thiouracil, a possible radiopharmaceutical for noninvasive detection of ocular melanoma, in melanotic and amelanotic melanomas in hamsters Nuclear medicine communications 1985;6 (10):657-663 [PubMed]