N.C. Hauck PhD publications

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Publications PhD N.C. Hauck

Position
Research Associate
Main activities
Research
Specialisation
Organ protection, molecular mechanisms "conditioning", inflammation, endothelial research
Focus of research

 

Our research group within the L.E.I.C.A laboratory focusses primarily on protection of heart, blood vessels  (endothelium) and other organs against temporary periods of no oxygen. No oxygen conditions occur frequently in several clinical conditions (surgery, cardiac by-pass operations, shock, stroke, transplantation) and during an acute heart attack. This research therefore has a high clinical and society relevance: it can lead to improvements in clinical care and in the fight against cardiovascular diseases.

Main research focus is

Improving our understanding of underlying mechanisms of different organ protection strategies:

  • Currently we focus on the effects of the sodium glucose hydrogen exchange inhibitors like Empagliflozin on the hart and endothelium and whether these can offer protection in various damaging models. In this context different proteins are in the focus of our investigations: like Caveolins, Hexokinase II and AMPK, eNOS and others.

     

  • Another focus over the last years is ischemic conditioning, remote ischemic preconditioning, and conditioning with special anaesthetic agents as clinically-applicable interventions to protect the organ/tissue against period of no oxygen. As the translation of these intervention has broadly failed we seeks to find more clinically relevant intervention/intervention combination within our in vitro and in vivo models.

  • Organ protection by the noble gas (helium) is observed in experimental models and humans and it might be a perfect alternative as an organprotective intervention. In this project we focus on the potential of helium to affect extracellular vesicles that might be enriched in Cavelolin. In a translational approach using volunteer blood on endothelial cells we aim to find out if helium can itself induce remote conditioning.

 

Amsterdam UMC Research Institutes
AMC departments
All publications

2020

  • Uthman Laween Direct cardiac and endothelial effects of sodium/glucose cotransporter 2 inhibitors and the role of the sodium/hydrogen exchanger 1 2020. 233p. ISBN 9789463759069. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Hollmann Markus W., Preckel Prof. dr. , Benedikt; Co-supervisors: Zuurbier Coert J., Hauck-Weber Nina C.)
  • Zhang Hong, Uthman Laween, Bakker Diane, Sari Sahinda, Chen Sha, Hollmann Markus W, Coronel Ruben, Weber Nina C, Houten Sander M, van Weeghel Michel, Zuurbier Coert J Empagliflozin Decreases Lactate Generation in an NHE-1 Dependent Fashion and Increases α-Ketoglutarate Synthesis From Palmitate in Type II Diabetic Mouse Hearts Frontiers in cardiovascular medicine 2020;7:592233 [PubMed]
  • Zhang Hong, Xiao Yang, Nederlof Rianne, Bakker Diane, Zhang Pengbo, Girardin Stephen E., Hollmann Markus W., Weber Nina C., Houten Sander M., van Weeghel Michel, Kibbey Richard G., Zuurbier Coert J. NLRX1 Deletion Increases Ischemia-Reperfusion Damage and Activates Glucose Metabolism in Mouse Heart Frontiers in immunology 2020;11 [PubMed]
  • Uthman Laween, Kuschma Marius, Römer Gregor, Boomsma Marleen, Kessler Jens, Hermanides Jeroen, Hollmann Markus W., Preckel Benedikt, Zuurbier Coert J., Weber Nina C. Novel Anti-inflammatory Effects of Canagliflozin Involving Hexokinase II in Lipopolysaccharide-Stimulated Human Coronary Artery Endothelial Cells Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2020 [PubMed]
  • Torregroza Carolin, Raupach Annika, Feige Katharina, Weber Nina C., Hollmann Markus W., Huhn Ragnar Perioperative Cardioprotection: General Mechanisms and Pharmacological Approaches Anesthesia and analgesia 2020:1765-1780 [PubMed]
  • Wirtz Mathijs R., Almizraq Ruqayyah J., Weber Nina C., Norris Philip J., Pandey Suchitra, Spinella Philip C., Muszynski Jennifer A., P. Acker Jason, Juffermans Nicole P. Red-blood-cell manufacturing methods and storage solutions differentially induce pulmonary cell activation Vox sanguinis 2020;115 (5):395-404 [PubMed]
  • Brevoord Daniel Translating organ conditioning: On the use of remote ischaemia and helium 2020. 177p. ISBN 9789463809856. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Hollmann Markus W., Preckel Prof. dr. , Benedikt; Co-supervisors: Hauck-Weber Nina C., Horn Johanna)

2019

  • Uthman Laween, Nederlof Rianne, Eerbeek Otto, Baartscheer Antonius, Schumacher Cees, Buchholtz Ninée, Hollmann Markus W, Coronel Ruben, Weber Nina C, Zuurbier Coert J Delayed ischaemic contracture onset by empagliflozin associates with NHE1 inhibition and is dependent on insulin in isolated mouse hearts Cardiovascular research 2019;115 (10):1533-1545 [PubMed]
  • Uthman Laween, Homayr Anna, Juni Rio P., Spin Eva L., Kerindongo Raphaela, Boomsma Marleen, Hollmann Markus W., Preckel Benedikt, Koolwijk Pieter, van Hinsbergh Victor W. M., Zuurbier Coert J., Albrecht Martin, Weber Nina C. Empagliflozin and Dapagliflozin Reduce ROS Generation and Restore NO Bioavailability in Tumor Necrosis Factor α-Stimulated Human Coronary Arterial Endothelial Cells Cellular physiology and biochemistry 2019;53 (5):865-886 [PubMed]
  • Weber Nina C., Schilling Jan M., Warmbrunn Moritz V., Dhanani Mehul, Kerindongo Raphaela, Siamwala Jamila, Song Young, Zemljic-Harpf Alice E., Fannon McKenzie J., Hollmann Markus W., Preckel Benedikt, Roth David M., Patel Hemal H. Helium-Induced Changes in Circulating Caveolin in Mice Suggest a Novel Mechanism of Cardiac Protection International journal of molecular sciences 2019;20 (11) [PubMed]
  • Smit Kirsten F., Oei Gezina T. M. L., Konkel Moritz, Augustijn Quinten J. J., Hollmann Markus W., Preckel Benedikt, Patel Hemal H., Weber Nina C. Plasma from Volunteers Breathing Helium Reduces Hypoxia-Induced Cell Damage in Human Endothelial Cells—Mechanisms of Remote Protection Against Hypoxia by Helium Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2019 [PubMed]

2018

  • Uthman Laween, Baartscheer Antonius, Bleijlevens Boris, Schumacher Cees A., Fiolet Jan W. T., Koeman Anneke, Jancev Milena, Hollmann Markus W., Weber Nina C., Coronel Ruben, Zuurbier Coert J. Class effects of SGLT2 inhibitors in mouse cardiomyocytes and hearts: inhibition of Na+/H+ exchanger, lowering of cytosolic Na+ and vasodilation Diabetologia 2018;61 (3):722-726 [PubMed]
  • Uthman Laween, Baartscheer Antonius, Schumacher Cees A, Fiolet Jan W T, Kuschma Marius C, Hollmann Markus W, Coronel Ruben, Weber Nina C, Zuurbier Coert J Direct Cardiac Actions of Sodium Glucose Cotransporter 2 Inhibitors Target Pathogenic Mechanisms Underlying Heart Failure in Diabetic Patients Frontiers in physiology 2018;9:1575 [PubMed]
  • Aehling C., Weber N. C., Zuurbier C. J., Preckel B., Galmbacher R., Stefan K., Hollmann M. W., Popp E., Knapp J. Effects of combined helium pre/post-conditioning on the brain and heart in a rat resuscitation model Acta anaesthesiologica Scandinavica 2018;62 (1):63-74 [PubMed]
  • Smit Kirsten F., Konkel Moritz, Kerindongo Raphaela, Landau Maximilian A., Zuurbier Coert J., Hollmann Markus W., Preckel Benedikt, Nieuwland Rienk, Albrecht Martin, Weber Nina C. Helium alters the cytoskeleton and decreases permeability in endothelial cells cultured in vitro through a pathway involving Caveolin-1 Scientific reports 2018;8 (1) [PubMed]
  • Weber Nina C., Zuurbier Coert J., Hollmann Markus W. Remote ischaemic preconditioning of the lung: From bench to bedside - Are we there yet? Journal of thoracic disease 2018;10 (1):98-101 [PubMed]
  • Ney Julia, Hoffmann Katleen, Meybohm Patrick, Goetzenich Andreas, Kraemer Sandra, Benstöm Carina, Weber Nina C., Bickenbach Johannes, Rossaint Rolf, Marx Gernot, Zacharowski Kai, Bernhagen J. rgen, Stoppe Christian Remote ischemic preconditioning does not affect the release of humoral factors in propofol-anesthetized cardiac surgery patients: A secondary analysis of the RIPHeart study International journal of molecular sciences 2018;19 (4) [PubMed]

2017

  • Nederlof Rianne, Weber Nina C., Juffermans Nicole P., de Mol Bas A. M. J., Hollmann Markus W., Preckel Benedikt, Zuurbier Coert J. A randomized trial of remote ischemic preconditioning and control treatment for cardioprotection in sevoflurane-anesthetized CABG patients BMC anesthesiology 2017;17 (1) [PubMed]
  • Nederlof Rianne, van den Elshout Mark A. M., Koeman Anneke, Uthman Laween, Koning Iris, Eerbeek Otto, Weber Nina C., Hollmann Markus W., Zuurbier Coert J. Cyclophilin D ablation is associated with increased end-ischemic mitochondrial hexokinase activity Scientific reports 2017;7 (1):12749 [PubMed]
  • Hofland Jan, Ouattara Alexandre, Fellahi Jean-Luc, Gruenewald Matthias, Hazebroucq Jean, Ecoffey Claude, Joseph Pierre, Heringlake Matthias, Steib Annick, Coburn Mark, Amour Julien, Rozec Bertrand, Liefde Inge de, Meybohm Patrick, Preckel Benedikt, Hanouz Jean-Luc, Tritapepe Luigi, Tonner Peter, Benhaoua Hamina, Roesner Jan Patrick, Bein Berthold, Hanouz Luc, Tenbrinck Rob, Bogers Ad J. J. C., Mik Bert G., Coiffic Alain, Renner Jochen, Steinfath Markus, Francksen Helga, Broch Ole, Haneya Assad, Schaller Manuella, Guinet Patrick, Daviet Lauren, Brianchon Corinne, Rosier Sebastien, Lehot Jean-Jacques, Paarmann Hauke, Schön Julika, Hanke Thorsten, Ettel Joachym, Olsson Silke, Klotz Stefan, Samet Amir, Laurinenas Giedrius, Thibaud Adrien, Cristinar Mircea, Collanges Olivier, Levy François, Rossaint Rolf, Stevanovic Ana, Schaelte Gereon, Stoppe Christian, Hamou Nora Ait, Hariri Sarah, Quessard Astrid, Carillion Aude, Morin Hélène, Silleran Jacqueline, Robert David, Crouzet Anne-Sophie, Zacharowski Kai, Reyher Christian, Iken Sonja, Weber Nina C., Hollmann Marcus, Eberl Susanne, Carriero Giovanni, Collacchi Daria, Di Persio Alessandra, Fourcade Olivier, Bergt Stefan, Alms Angela Effect of Xenon Anesthesia Compared to Sevoflurane and Total Intravenous Anesthesia for Coronary Artery Bypass Graft Surgery on Postoperative Cardiac Troponin Release: An International, Multicenter, Phase 3, Single-blinded, Randomized Noninferiority Trial Anesthesiology 2017;127 (6):918-933 [PubMed]
  • Nederlof Rianne Mitochondrial hexokinase and ischemic sensitivity and metabolism of the heart 2017. 259p. ISBN 9789492801098. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Hollmann M. W., Preckel B.; Co-supervisors: Zuurbier C. J., Hauck-Weber N. C.)
  • Smit Kirsten F. Organ protection by the noble gas helium 2017. 237p. ISBN 9789492683212. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Preckel B., Hollmann M. W.; Co-supervisors: Hauck-Weber N. C., Zuurbier C. J.)

2016

  • Witteveen Esther, Hoogland Inge C. M., Wieske Luuk, Weber Nina C., Verhamme Camiel, Schultz Marcus J., van Schaik Ivo N., Horn Janneke Assessment of intensive care unit-acquired weakness in young and old mice: An E. coli septic peritonitis model Muscle & nerve 2016;53 (1):127-133 [PubMed]
  • Smit Kirsten F., Brevoord Daniel, de Hert Stefan, de Mol Bas A., Kerindongo Raphaela P., van Dieren Susan, Schlack Wolfgang S., Hollmann Markus W., Weber Nina C., Preckel Benedikt Effect of helium pre- or postconditioning on signal transduction kinases in patients undergoing coronary artery bypass graft surgery Journal of translational medicine 2016;14 (1):294 [PubMed]
  • Flick Moritz, Albrecht Martin, Oei Gezina T. M. L., Steenstra Renske, Kerindongo Raphaela P., Zuurbier Coert J., Patel Hemal H., Hollmann Markus W., Preckel Benedikt, Weber Nina C. Helium postconditioning regulates expression of caveolin-1 and -3 and induces RISK pathway activation after ischaemia/reperfusion in cardiac tissue of rats European journal of pharmacology 2016;791:718-725 [PubMed]
  • Straat Marleen, van Hezel Maike E., Böing Anita, Tuip-de Boer Anita, Weber Nina, Nieuwland Rienk, van Bruggen Robin, Juffermans Nicole P. Monocyte-mediated activation of endothelial cells occurs only after binding to extracellular vesicles from red blood cell products, a process mediated by β-integrin Transfusion 2016;56 (12):3012-3020 [PubMed]
  • Nederlof Rianne, Gürel-Gurevin Ebru, Eerbeek Otto, Xie Chaoqin, Deijs G. Sjoerd, Konkel Moritz, Hu Jun, Weber Nina C., Schumacher Cees A., Baartscheer Antonius, Mik Egbert G., Hollmann Markus W., Akar Fadi G., Zuurbier Coert J. Reducing mitochondrial bound hexokinase II mediates transition from non-injurious into injurious ischemia/reperfusion of the intact heart Journal of physiology and biochemistry 2016;73 (3):323-333 [PubMed]

2015

  • Weber Nina C. 'Conditioning the heart' - lessons we have learned from the past and future perspectives for new and old conditioning 'drugs' British journal of pharmacology 2015;172 (8):1909-1912 [PubMed]
  • Smit Kirsten F., Kerindongo Raphaela P., Böing Anita, Nieuwland Rienk, Hollmann Markus W., Preckel Benedikt, Weber Nina C. Effects of helium on inflammatory and oxidative stress-induced endothelial cell damage Experimental cell research 2015;337 (1):37-43 [PubMed]
  • Lirk P., Fiegl H., Weber N. C., Hollmann M. W. Epigenetics in the perioperative period British journal of pharmacology 2015;172 (11):2748-2755 [PubMed]
  • Smit Kirsten F., Weber Nina C., Hollmann Markus W., Preckel Benedikt Noble gases as cardioprotectants - translatability and mechanism British journal of pharmacology 2015;172 (8):2062-2073 [PubMed]
  • Weber Nina C., Riedemann Isabelle, Smit Kirsten F., Zitta Karina, van de Vondervoort Djai, Zuurbier Coert J., Hollmann Markus W., Preckel Benedikt, Albrecht Martin Plasma from human volunteers subjected to remote ischemic preconditioning protects human endothelial cells from hypoxia-induced cell damage Basic research in cardiology 2015;110 (2):17 [PubMed]
  • Oei Gezina Tanya Mei Ling, Aslami Hamid, Kerindongo Raphaela Priscilla, Steenstra Renske Johanna, Beurskens Charlotte Jacqueline Peter, Tuip-de Boer Anita Maria, Juffermans Nicole Petra, Hollmann Markus Werner, Preckel Benedikt, Weber Nina Claudia Prolonged helium postconditioning protocols during early reperfusion do not induce cardioprotection in the rat heart in vivo: role of inflammatory cytokines Journal of immunology research 2015;2015:216798 [PubMed]
  • Fraessdorf Jan, Hollmann Markus W., Hanschmann Iris, Heinen André, Weber Nina C., Preckel Benedikt, Huhn Ragnar Role of Endogenous Opioid System in Ischemic-Induced Late Preconditioning PLoS ONE 2015;10 (7):e0134283 [PubMed]
  • Weber Nina C., Smit Kirsten F., Hollmann Markus W., Preckel Benedikt Targets Involved in Cardioprotection by the Non-Anesthetic Noble Gas Helium Current drug targets 2015;16 (8):786-792 [PubMed]

2014

  • Zuurbier Coert J., Heinen Andre, Koeman Anneke, Stuifbergen Roy, Hakvoort Theodorus B. M., Weber Nina C., Hollmann Markus W. Cardioprotective efficacy depends critically on pharmacological dose, duration of ischaemia, health status of animals and choice of anaesthetic regimen: a case study with folic acid Journal of translational medicine 2014;12 (1):325 [PubMed]
  • Fastner Christian, Mairbäurl Heimo, Weber Nina C., van der Sluijs Koen, Hackl Florian, Hotz Lorenz, Dahan Albert, Hollmann Markus W., Berger Marc M. Intravenous S-ketamine does not inhibit alveolar fluid clearance in a septic rat model PLoS ONE 2014;9 (11):e112622 [PubMed]
  • Dyballa-Rukes Nadine, Schuh Christian, Vogt Hendrik, Toma Octavian, Schlack Wolfgang S., Weber Nina C., Metzger Sabine In vivo desflurane preconditioning evokes dynamic alterations of metabolic proteins in the heart--proteomic insights strengthen the link between bioenergetics and cardioprotection Cellular physiology and biochemistry 2014;33 (4):967-981 [PubMed]
  • Lirk P., Hollmann M. W., Fleischer M., Weber N. C., Fiegl H. Lidocaine and ropivacaine, but not bupivacaine, demethylate deoxyribonucleic acid in breast cancer cells in vitro British journal of anaesthesia 2014;113 (Suppl. 1):i32-i38 [PubMed]
  • Lirk Philipp Local anesthetics: New insights into risks and benefits 2014. 322p. ISBN 9789088919008. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Hollmann M. W.; Co-supervisors: Hauck-Weber N. C., Stevens M. F.)
  • Jong Willeke M. C., Leemans Jaklien C., Weber Nina C., Juffermans Nicole P., Schultz Marcus J., Hollmann Markus W., Zuurbier Coert J. Nlrp3 plays no role in acute cardiac infarction due to low cardiac expression International journal of cardiology 2014;177 (1):41-43 [PubMed]
  • Oei Gezina T. M. L., Heger Michal, van Golen Rowan F., Alles Lindy K., Flick Moritz, van der Wal Allard C., van Gulik Thomas M., Hollmann Markus W., Preckel Benedikt, Weber Nina C. Reduction of cardiac cell death after helium postconditioning in rats: transcriptional analysis of cell death and survival pathways Molecular medicine (Cambridge, Mass.) 2014;20:516-526 [PubMed]

2013

  • Smit Kirsten F., Hollmann Markus W., Weber Nina C., Preckel Benedikt Does Helium Act on Vascular Endothelial Function in Humans? Reply Anesthesiology 2013;119 (2):488-489 [PubMed]
  • Oei Gezina T. M. L. Helium-induced cardioprotection: in sickness and in health, for better or for worse? 2013. 268p. ISBN 9789088917486. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Hollmann M. W., Preckel B.; Co-supervisor: Hauck-Weber N. C.)
  • Smit Kirsten F., Oei Gezina T. M. L., Brevoord Daniel, Stroes Erik S., Nieuwland Rienk, Schlack Wolfgang S., Hollmann Markus W., Weber Nina C., Preckel Benedikt Helium induces preconditioning in human endothelium in vivo Anesthesiology 2013;118 (1):95-104 [PubMed]
  • Aslami Hamid, Pulskens Wilco P., Kuipers Maria T., Bos Aafkeline P., van Kuilenburg André B. P., Wanders Ronald J. A., Roelofsen Jeroen, Roelofs Joris J. T. H., Kerindongo Raphaela P., Beurskens Charlotte J. P., Schultz Marcus J., Kulik Wim, Weber Nina C., Juffermans Nicole P. Hydrogen sulfide donor NaHS reduces organ injury in a rat model of pneumococcal pneumosepsis, associated with improved bio-energetic status PLoS ONE 2013;8 (5):e63497 [PubMed]

2012

  • Huhn Ragnar, Weber Nina C., Preckel Benedikt, Schlack Wolfgang, Bauer Inge, Hollmann Markus W., Heinen André Age-related loss of cardiac preconditioning: Impact of protein kinase A Experimental gerontology 2012;47 (1):116-121 [PubMed]
  • Frässdorf Jan Anesthetic induced cardioprotection: from bench to bedside and retour 2012. 318p. ISBN 9789088914928. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Hollmann M. W., Schlack W. S.; Co-supervisors: Hauck N. C., Preckel B.)
  • Oei Gezina T. M. L., Smit Kirsten F., vd Vondervoort Djai, Brevoord Daniel, Hoogendijk Arjan, Wieland Catharina W., Hollmann Markus W., Preckel Benedikt, Weber Nina C. Effects of helium and air inhalation on the innate and early adaptive immune system in healthy volunteers ex vivo Journal of translational medicine 2012;10 (1):201 [PubMed]
  • Oei Gezina T. M. L., Huhn Ragnar, Heinen Andre, Hollmann Markus W., Schlack Wolfgang S., Preckel Benedikt, Weber Nina C. Helium-induced cardioprotection of healthy and hypertensive rat myocardium in vivo European journal of pharmacology 2012;684 (1-3):125-131 [PubMed]
  • Brevoord Daniel, Kranke Peter, Kuijpers Marijn, Weber Nina, Hollmann Markus, Preckel Benedikt Remote Ischemic Conditioning to Protect against Ischemia-Reperfusion Injury: A Systematic Review and Meta-Analysis PLoS ONE 2012;7 (7):e42179 [PubMed]

2011

  • Brevoord Daniel, Hollmann Markus W., de Hert Stefan G., van Dongen Eric H. P. A., Heijnen Bram G. A. D. H., de Bruin Anton, Tolenaar Noortje, Schlack Wolfgang S., Weber Nina C., Dijkgraaf Marcel G. W., de Groot Joris R., de Mol Bas A. J. M., Driessen Antoine H. G., Momeni Mona, Wouters Patrick, Bouchez Stefaan, Hofland Jan, Luthen Christian, Meijer-Treschan Tanja A., Pannen Benedikt H., Preckel Benedikt Effect of Remote Ischemic Conditioning on atrial fibrillation and Outcome after coronary artery bypass grafting (RICO-trial) BMC anesthesiology 2011;11 (1):11 [PubMed]
  • Smeele Kirsten M., ter Horst Leontien H., Koeman Anneke, Heikkinen Sami, Laakso Markku, Weber Nina C., Hollmann Markus W., Zuurbier Coert J. The effect of standard chow and reduced hexokinase II on growth, cardiac and skeletal muscle hexokinase and low-flow cardiac ischaemia-reperfusion injury Laboratory animals 2011;45 (3):160-166 [PubMed]

2010

  • Oei Gezina T. M. L., Weber Nina C., Hollmann Markus W., Preckel Benedikt Cellular Effects of Helium in Different Organs Anesthesiology 2010;112 (6):1503-1510 [PubMed]
  • Huhn R., Heinen A., Hollmann M. W., Schlack W., Preckel B., Weber N. C. Cyclosporine A administered during reperfusion fails to restore cardioprotection in prediabetic Zucker obese rats in vivo Nutrition, metabolism, and cardiovascular diseases 2010;20 (10):706-712 [PubMed]
  • Berger Marc M., Huhn Ragnar, Oei Gezina T., Heinen André, Winzer Andreas, Bauer Inge, Preckel Benedikt, Weber Nina C., Schlack Wolfgang, Hollmann Markus W. Hypoxia Induces Late Preconditioning in the Rat Heart In Vivo Anesthesiology 2010;113 (6):1351-1360 [PubMed]
  • Huhn R., Heinen A., Weber N. C., Schlack W., Preckel B., Hollmann M. W. Ischaemic and morphine-induced post-conditioning: impact of mK(Ca) channels British journal of anaesthesia 2010;105 (5):589-595 [PubMed]
  • Fräßdorf Jan, Huhn Ragnar, Niersmann Corinna, Weber Nina C., Schlack Wolfgang, Preckel Benedikt, Hollmann Markus W. Morphine induces preconditioning via activation of mitochondrial K(Ca) channels La morphine provoque le préconditionnement par l'activation des canaux mitochondriaux K(Ca) Canadian journal of anaesthesia = Journal canadien d'anesthésie 2010;57 (8):767-773 [PubMed]
  • Schwiebert Christian, Huhn Ragnar, Heinen Andre, Weber Nina C., Hollmann Markus W., Schlack Wolfgang, Preckel Benedikt Postconditioning by xenon and hypothermia in the rat heart in vivo European journal of anaesthesiology 2010;27 (8):734-739 [PubMed]
  • Fräßdorf Jan, Huhn Ragnar, Weber Nina C., Ebel Dirk, Wingert Nadja, Preckel Benedikt, Toma Octavian, Schlack Wolfgang, Hollmann Markus W. Sevoflurane-induced Preconditioning Impact of Protocol and Aprotinin Administration on Infarct Size and Endothelial Nitric-Oxide Synthase Phosphorylation in the Rat Heart In Vivo Anesthesiology 2010;113 (6):1289-1298 [PubMed]

2009

  • Huhn Ragnar Cardioprotection with helium and anesthetics in healthy and diseased myocardium 2009. 187p. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Schlack W. S., Hollmann M. W.; Co-supervisors: Preckel B., Hauck N. C.)
  • Huhn R., Heinen A., Weber N. C., Kerindongo R. P., Oei G. T. M. L., Hollmann M. W., Schlack W., Preckel B. Helium-induced early preconditioning and postconditioning are abolished in obese Zucker rats in vivo Journal of pharmacology and experimental therapeutics 2009;329 (2):600-607 [PubMed]
  • Huhn R., Heinen A., Weber N. C., Hieber S., Hollmann M. W., Schlack W., Preckel B. Helium-induced late preconditioning in the rat heart in vivo British journal of anaesthesia 2009;102 (5):614-619 [PubMed]
  • Hieber Stefanie, Huhn Ragnar, Hollmann Markus W., Weber Nina C., Preckel Benedikt Hypoxia-inducible factor 1 and related gene products in anaesthetic-induced preconditioning European journal of anaesthesiology 2009;26 (3):201-206 [PubMed]
  • Frässdorf Jan, Borowski Andreas, Ebel Dirk, Feindt Peter, Hermes Manuel, Meemann Thomas, Weber René, Müllenheim Jost, Weber Nina C., Preckel Benedikt, Schlack Wolfgang Impact of preconditioning protocol on anesthetic-induced cardioprotection in patients having coronary artery bypass surgery Journal of thoracic and cardiovascular surgery 2009;137 (6):1436-42, 1442.e1-2 [PubMed]
  • Ebel D., Toma O., Appler S., Baumann K., Fräßdorf J., Preckel B., Rösen P., Schlack W., Weber N. C. Ischemic Preconditioning Phosphorylates Mitogen-activated Kinases and Heat Shock Protein 27 in the Diabetic Rat Heart Hormone and metabolic research. Hormon- und Stoffwechselforschung. Hormones et metabolisme 2009;41 (1):10-15 [PubMed]

2008

  • Weber Nina C., Goletz Christine, Huhn Ragnar, Grueber Yvonne, Preckel Benedikt, Schlack Wolfgang, Ebel Dirk Blockade of anaesthetic-induced preconditioning in the hyperglycaemic myocardium - The regulation of different mitogen-activated protein kinases European journal of pharmacology 2008;592 (1-3):48-54 [PubMed]
  • Heinen Andre, Huhn Ragnar, Smeele Kirsten M. A., Zuurbier Coert J., Schlack Wolfgang, Preckel Benedikt, Weber Nina C., Hollmann Markus W. Helium-induced preconditioning in young and old rat heart: impact of mitochondrial Ca(2+) -sensitive potassium channel activation Anesthesiology 2008;109 (5):830-836 [PubMed]
  • Huhn R., Heinen A., Weber N. C., Hollmann M. W., Schlack W., Preckel B. Hyperglycaemia blocks sevoflurane-induced postconditioning in the rat heart in vivo: cardioprotection can be restored by blocking the mitochondrial permeability transition pore British journal of anaesthesia 2008;100 (4):465-471 [PubMed]
  • Weber N. C., Schlack W. Inhalational anaesthetics and cardioprotection Handbook of experimental pharmacology 2008;182 (182):187-207 [PubMed]
  • Weber Nina C., Kandler Jennis, Schlack Wolfgang, Grueber Yvonne, Frädorf Jan, Preckel Benedikt Intermitted pharmacologic pretreatment by xenon, isoflurane, nitrous oxide, and the opioid morphine prevents tumor necrosis factor alpha-induced adhesion molecule expression in human umbilical vein endothelial cells Anesthesiology 2008;108 (2):199-207 [PubMed]
  • Weber Nina C., Schlack Wolfgang, Preckel Benedikt Molecular biology in cardiovascular anaesthesia Current opinion in anaesthesiology 2008;21 (1):71-77 [PubMed]
  • Heinen André, Huhn Ragnar, Hollmann Markus W., Preckel Benedikt, Zuurbier Coert J., Schlack Wolfgang, Frässdorf Jan, Weber Nina C. Physiological levels of glutamine prevent morphine-induced preconditioning in the isolated rat heart European journal of pharmacology 2008;595 (1-3):58-64 [PubMed]
  • Heinen André, Winning Adrian, Schlack Wolfgang, Hollmann Markus W., Preckel Benedikt, Frässdorf Jan, Weber Nina C. The regulation of mitochondrial respiration by opening of mKCa channels is age-dependent European journal of pharmacology 2008;578 (2-3):108-113 [PubMed]
  • Heinen André The role of mitochondria in cardioprotection 2008. 177p. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Hollmann M. W., Schlack W. S.; Co-supervisors: Hauck N. C., Preckel B.)
  • Weber Nina C., Fräβdorf Jan, Ratajczak Christoph, Grueber Yvonne, Schlack Wolfgang, Hollmann Markus W., Preckel Benedikt Xenon Induces Late Cardiac Preconditioning In Vivo: A Role for Cyclooxygenase 2? Anesthesia and analgesia 2008;107 (6):1807-1813 [PubMed]

2006

  • Preckel Benedikt, Weber Nina C., Sanders Robert D., Maze Mervyn, Schlack Wolfgang Molecular mechanisms transducing the anesthetic, analgesic, and organ-protective actions of xenon Anesthesiology 2006;105 (1):187-197 [PubMed]
  • Weber Nina C., Preckel Benedikt, Schlack Wolfgang Nitrous oxide and preconditioning - Reply Anesthesiology 2006;105 (3):631
  • Weber Nina C., Toma Octavian, Damla Halil, Wolter Jessica I., Schlack Wolfgang, Preckel Benedikt Upstream signaling of protein kinase C-epsilon in xenon-induced pharmacological preconditioning. Implication of mitochondrial adenosine triphosphate dependent potassium channels and phosphatidylinositol-dependent kinase-1 European journal of pharmacology 2006;539 (1-2):1-9 [PubMed]
  • Weber N. C., Stursberg J., Wirthle N. M., Toma O., Schlack W., Preckel B. Xenon preconditioning differently regulates p44/42 MAPK (ERK 1/2) and p46/54 MAPK (JNK 1/2 and 3) in vivo British journal of anaesthesia 2006;97 (3):298-306 [PubMed]

2005

  • Weber Nina C., Toma Octavian, Awan Saqib, Frässdorf Jan, Preckel Benedikt, Schlack Wolfgang Effects of nitrous oxide on the rat heart in vivo: another inhalational anesthetic that preconditions the heart? Anesthesiology 2005;103 (6):1174-1182 [PubMed]
  • Preckel Benedikt, Weber N. C., Schlack W. Kardioprotektion durch xenon Journal fur Anasthesie und Intensivbehandlung 2005;12 (2):102
  • Weber Nina C., Toma Octavian, Wolter Jessica I., Wirthle Nicole M., Schlack Wolfgang, Preckel Benedikt Mechanisms of xenon- and isoflurane-induced preconditioning - a potential link to the cytoskeleton via the MAPKAPK-2/HSP27 pathway British journal of pharmacology 2005;146 (3):445-455 [PubMed]
  • Frässdorf Jan, Weber Nina C., Obal Detlef, Toma Octavian, Müllenheim Jost, Kojda Georg, Preckel Benedikt, Schlack Wolfgang Morphine induces late cardioprotection in rat hearts in vivo: the involvement of opioid receptors and nuclear transcription factor kappaB Anesthesia and analgesia 2005;101 (4):934-41, table of contents [PubMed]
  • Obal D., Weber N. C., Zacharowski K., Toma O., Dettwiler S., Wolter J. I., Kratz M., Müllenheim J., Preckel B., Schlack W. Role of protein kinase C-epsilon (PKCepsilon) in isoflurane-induced cardioprotection British journal of anaesthesia 2005;94 (2):166-173 [PubMed]
  • Weber Nina C., Schlack Wolfgang The concept of anaesthetic-induced cardioprotection: mechanisms of action Best practice & research. Clinical anaesthesiology 2005;19 (3):429-443 [PubMed]
  • Weber N. C., Preckel B., Schlack W. The effect of anaesthetics on the myocardium--new insights into myocardial protection European journal of anaesthesiology 2005;22 (9):647-657 [PubMed]
  • Weber Nina C., Toma Octavian, Wolter Jessica I., Obal Detlef, Müllenheim Jost, Preckel Benedikt, Schlack Wolfgang The noble gas xenon induces pharmacological preconditioning in the rat heart in vivo via induction of PKC-epsilon and p38 MAPK British journal of pharmacology 2005;144 (1):123-132 [PubMed]

2004

  • Toma Octavian, Weber Nina C., Wolter Jessica I., Obal Detlef, Preckel Benedikt, Schlack Wolfgang Desflurane preconditioning induces time-dependent activation of protein kinase C epsilon and extracellular signal-regulated kinase 1 and 2 in the rat heart in vivo Anesthesiology 2004;101 (6):1372-1380 [PubMed]
  • Preckel B., Weber N., Schlack W. Xenon - Edelgas mit organprotektiven Eigenschaften Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie 2004;39 (8):456-462 [PubMed]

2003

  • Weber Nina C., Blumenthal Signe B., Hartung Thomas, Vollmar Angelika M., Kiemer Alexandra K. ANP inhibits TNF-alpha-induced endothelial MCP-1 expression--involvement of p38 MAPK and MKP-1 Journal of leukocyte biology 2003;74 (5):932-941 [PubMed]
  • Kiemer Alexandra K., Bildner Nicole, Weber Nina C., Vollmar Angelika M. Characterization of heme oxygenase 1 (heat shock protein 32) induction by atrial natriuretic peptide in human endothelial cells Endocrinology 2003;144 (3):802-812 [PubMed]

2002

  • Kiemer Alexandra K., Weber Nina C., Vollmar Angelika M. Induction of IkappaB: atrial natriuretic peptide as a regulator of the NF-kappaB pathway Biochemical and biophysical research communications 2002;295 (5):1068-1076 [PubMed]
  • Kiemer Alexandra K., Weber Nina C., Fürst Robert, Bildner Nicole, Kulhanek-Heinze Stefanie, Vollmar Angelika M. Inhibition of p38 MAPK activation via induction of MKP-1: atrial natriuretic peptide reduces TNF-alpha-induced actin polymerization and endothelial permeability Circulation research 2002;90 (8):874-881 [PubMed]
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