R.B. Takkenberg PhD publications

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Publications PhD R.B. Takkenberg

Position
Medical Specialist
Main activities
Education, Patient care, Research
Specialisation
Hepatologist: viral hepatitis, hepatocellular carcinoma, and portal hypertension
Focus of research

 Hepatocellular caricoma, non-invasive maesurments of portal hypertension, imaging

2021

  • van Doorn Diederick J., Takkenberg Robert Bart, Klümpen Heinz-Josef Immune checkpoint inhibitors in hepatocellular carcinoma: An overview Pharmaceuticals 2021;14 (1):1-23 [PubMed]

2020

  • Klompenhouwer Anne J., van Rosmalen Belle V., Haring Martijn P. D., Thomeer Maarten G. J., Doukas Michail, Verheij Joanne, de Meijer Vincent E., van Gulik Thomas M., Takkenberg Robert B., Kazemier Geert, Nevens Frederik, de Man Robert A., Ijzermans Jan N. M. A multicentre retrospective analysis on growth of residual hepatocellular adenoma after resection Liver international 2020;40 (9):2272-2278 [PubMed]
  • de Vries Elsemieke, Mazzetti Marta, Takkenberg Bart, Mostafavi Nahid, Bikker Hennie, Marzioni Marco, de Veer Rozanne, van der Meer Adriaan, Doukas Michael, Verheij Joanne, Beuers Ulrich Carriers of ABCB4 gene variants show a mild clinical course, but impaired quality of life and limited risk for cholangiocarcinoma Liver international 2020;40 (12):3042-3050 [PubMed]
  • de Wit K., van Delden O. M., Beuers U., Takkenberg R. B. Doppler follow-up after tips placement is not routinely indicated. A 16-years single centre experience Netherlands journal of medicine 2020;78 (6):333-340 [PubMed]
  • de Vries Elsemieke S. Fibrosing cholangiopathies: Insights in clinical aspects and novel therapeutic approaches 2020. 209p. ISBN 9789463759328. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Beuers Ulrich H. W.; Co-supervisor: Takkenberg Bart B.)
  • Labeur Tim A., Berhane Sarah, Edeline Julien, Blanc Jean-Frederic, Bettinger Dominik, Meyer Tim, van Vugt Jeroen L. A., ten Cate David W. G., de Man Robert A., Eskens Ferry A. L. M., Cucchetti Alessandro, Bonnett Laura J., van Delden Otto M., Klümpen Heinz-Josef, Takkenberg R. Bart, Johnson Philip J. Improved survival prediction and comparison of prognostic models for patients with hepatocellular carcinoma treated with sorafenib Liver international 2020;40 (1):215-228 [PubMed]
  • Oude Nijhuis Renske A. B., Bergman Jacques J. G. H. M., Takkenberg R. Bart, Fockens Paul, Bredenoord Albert J. Non-surgical treatment of esophageal perforation after pneumatic dilation for achalasia: a case series Scandinavian journal of gastroenterology 2020;55 (10):1248-1252 [PubMed]
  • Labeur Tim A. Predicting outcomes and personalizing treatment in hepatocellular carcinoma 2020. 337p. ISBN 9789402821345. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van Delden Otto M.; Co-supervisors: Takkenberg Bart B., Klumpen Heinz-Josef)
  • Han Guohong, Berhane Sarah, Toyoda Hidenori, Bettinger Dominik, Elshaarawy Omar, Chan Anthony W. H., Kirstein Martha, Mosconi Cristina, Hucke Florian, Palmer Daniel, Pinato David J., Sharma Rohini, Ottaviani Diego, Jang Jeong W., Labeur Tim A., van Delden Otto M., Pirisi Mario, Stern Nick, Sangro Bruno, Meyer Tim, Fateen Waleed, García-Fiñana Marta, Gomaa Asmaa, Waked Imam, Rewisha Eman, Aithal Guru P., Travis Simon, Kudo Masatoshi, Cucchetti Alessandro, Peck-Radosavljevic Markus, Takkenberg R. B., Chan Stephen L., Vogel Arndt, Johnson Philip J. Prediction of Survival Among Patients Receiving Transarterial Chemoembolization for Hepatocellular Carcinoma: A Response-Based Approach Hepatology (Baltimore, Md.) 2020;72 (1):198-212 [PubMed]
  • de Wit K., Schaapman J. J., Nevens F., Verbeek J., Coenen S., Cuperus F. J. C., Kramer M., Tjwa E. T. T. L., Mostafavi N., DIjkgraaf M. G. W., van Delden O. M., Beuers U. H. W., Coenraad M. J., Takkenberg R. B. Prevention of hepatic encephalopathy by administration of rifaximin and lactulose in patients with liver cirrhosis undergoing placement of a transjugular intrahepatic portosystemic shunt (TIPS): A multicentre randomised, double blind, placebo controlled trial (PEARL trial) BMJ open gastroenterology 2020;7 (1) [PubMed]
  • Rassam Fadi Quantitative assessment of liver function using hepatobiliary scintigraphy 2020. [UvA Dissertations Online] (Supervisors: van Gulik Thomas M., Bennink Roel J.; Co-supervisors: Olthof Pim B., Takkenberg Bart B.)
  • Klompenhouwer Anne J., Alblas Maaike, van Rosmalen Belle V., Haring Martijn P. D., Venema Esmee, Doukas Michael, Thomeer Maarten G. J., Takkenberg Robert B., Verheij Joanne, de Meijer Vincent E., van Gulik Thomas M., Lingsma Hester F., de Man Robert A., Ijzermans Jan N. M. Response to Chen et al American journal of gastroenterology 2020;115 (1):147-148 [PubMed]
  • Labeur Tim A., Achterbergh Roos, Takkenberg Bart, van Delden Otto, Mathôt Ron, Klümpen Heinz-Josef Sorafenib for Patients with Hepatocellular Carcinoma and Child-Pugh B Liver Cirrhosis: Lessons Learned from a Terminated Study oncologist 2020;25 (9):e1274-e1279 [PubMed]
  • Labeur Tim A., Cieslak Kasia P., van Gulik Thomas M., Takkenberg R. Bart, van der Velden Sandra, Lam Marnix G. E. H., Klümpen Heinz-Josef, Bennink Roel J., van Delden Otto M. The utility of 99mTc-mebrofenin hepatobiliary scintigraphy with SPECT/CT for selective internal radiation therapy in hepatocellular carcinoma Nuclear medicine communications 2020;41 (8):740-749 [PubMed]
  • Labeur Tim A., Hofsink Quincy, Takkenberg R. Bart, van Delden Otto M., Mathôt Ron A. A., Schinner Regina, Malfertheiner Peter, Amthauer Holger, Schütte Kerstin, Basu Bristi, Kuhl Christiane, Mayerle Julia, Ricke Jens, Klümpen Heinz-Josef The value of sorafenib trough levels in patients with advanced hepatocellular carcinoma–a substudy of the SORAMIC trial Acta oncologica (Stockholm, Sweden) 2020;59 (9):1028-1035 [PubMed]

2019

  • Labeur Tim A., van Vugt Jeroen L. A., ten Cate David W. G., Takkenberg R. Bart, Ijzermans Jan N. M., Groot Koerkamp Bas, de Man Robert A., van Delden Otto M., Eskens Ferry A. L. M., Klümpen Heinz-Josef Body Composition Is an Independent Predictor of Outcome in Patients with Hepatocellular Carcinoma Treated with Sorafenib Liver Cancer 2019;8 (4):255-270 [PubMed]
  • Labeur Tim A., Takkenberg R. Bart, Klümpen Heinz-Josef, van Delden Otto M. Correction to: Reason of Discontinuation After Transarterial Chemoembolization Influences Survival in Patients with Hepatocellular Carcinoma (CardioVascular and Interventional Radiology, (2018), 10.1007/s00270-018-2118-6) Cardiovascular and interventional radiology 2019;42 (3):484-484 [PubMed]
  • Roos E., Soer E. C., Klompmaker S., Meijer L. L., Besselink M. G., Giovannetti E., Heger M., Kazemier G., Klümpen H. J., Takkenberg R. B., Wilmink H., Würdinger T., Dijk F., van Gulik T. M., Verheij J., van de Vijver M. J. Crossing borders: A systematic review with quantitative analysis of genetic mutations of carcinomas of the biliary tract Critical reviews in oncology/hematology 2019;140:8-16 [PubMed]
  • Klompenhouwer Anne Julia, Alblas Maaike, van Rosmalen Belle Vivica, Haring Martinus Petrus Daniel, Venema Esmee, Doukas Michail, Thomeer Maarten Guillaume Josephus, Takkenberg Robert Bart, Verheij Joanne, de Meijer Vincent Erwin, van Gulik Thomas Matthijs, Lingsma Hester Floor, de Man Robert Auke, Ijzermans Jan Nicolaas Maria Development and Validation of a Model to Predict Regression of Large Size Hepatocellular Adenoma American journal of gastroenterology 2019;114 (8):1292-1298 [PubMed]
  • Labeur Tim A., Runge Jurgen H., Klompenhouwer Elisabeth G., Klümpen Heinz-Josef, Takkenberg R. Bart, van Delden Otto M. Diffusion-weighted imaging of hepatocellular carcinoma before and after transarterial chemoembolization: role in survival prediction and response evaluation ABDOMINAL RADIOLOGY 2019;44 (8):2740-2750 [PubMed]
  • Roos Eva, Franken Lotte C., Soer Eline C., van Hooft Jeanin E., Takkenberg R. Bart, Klümpen Heinz-Josef, Wilmink Johanna W., van de Vijver Marc J., van Gulik Thomas M., Verheij Joanne Lost in translation: confusion on resection and dissection planes hampers the interpretation of pathology reports for perihilar cholangiocarcinoma Virchows Archiv 2019;475 (4):435-443 [PubMed]
  • Takkenberg R. B., Gecse Krisztina B., Dekker Evelien Maag-, darm- en leverziekten: Successen, teleurstellingen en een blik op de toekomst Nederlands tijdschrift voor geneeskunde 2019;163 (51)
  • Labeur Tim A., Takkenberg R. Bart, Klümpen Heinz-Josef, van Delden Otto M. Reason of Discontinuation After Transarterial Chemoembolization Influences Survival in Patients with Hepatocellular Carcinoma Cardiovascular and interventional radiology 2019;42 (2):230-238 [PubMed]
  • Furumaya Alicia, van Rosmalen Belle V, Takkenberg R Bart, van Delden Otto M, Dejong Cornelis H C, Verheij Joanne, van Gulik Thomas M Transarterial (Chemo-)Embolization and Lipiodolization for Hepatic Haemangioma Cardiovascular and interventional radiology 2019;42 (6):800-811 [PubMed]

2018

  • Mackay Tara Michella, Genç Cansu G. ney, Takkenberg Robert Bart, Besselink Marc Gerard, Somers Inne, Nieveen van Dijkum Elisabeth Jacqueline Maria New onset non-alcoholic fatty liver disease after resection of pancreatic neuroendocrine tumors Journal of surgical oncology 2018;117 (7):1548-1555 [PubMed]
  • Oey Rosalie C., de Wit Koos, Moelker Adriaan, Atalik Tugce, van Delden Otto M., Maleux Geert, Erler Nicole S., Takkenberg R. Bart, de Man Robert A., Nevens Frederik, van Buuren Henk R. Variable efficacy of TIPSS in the management of ectopic variceal bleeding: a multicentre retrospective study Alimentary pharmacology & therapeutics 2018;48 (9):975-983 [PubMed]

2017

  • Stelma F., van der Ree M. H., Jansen L., Peters M. W., Janssen H. L. A., Zaaijer H. L., Takkenberg R. Bart, Reesink H. W. HBsAg loss after peginterferon-nucleotide combination treatment in chronic hepatitis B patients: 5 years of follow-up Journal of viral hepatitis 2017;24 (12):1107-1113 [PubMed]
  • de Niet Annikki, Jansen Louis, Stelma Femke, Willemse Sophie B., Kuiken Sjoerd D., Weijer Sebastiaan, van Nieuwkerk Carin M. J., Zaaijer Hans L., Molenkamp Richard, Takkenberg R. Bart, Koot Maarten, Verheij Joanne, Beuers Ulrich, Reesink Hendrik W. Peg-interferon plus nucleotide analogue treatment versus no treatment in patients with chronic hepatitis B with a low viral load: a randomised controlled, open-label trial lancet. Gastroenterology & hepatology 2017;2 (8):576-584 [PubMed]
  • van der Ree Meike H., Jansen Louis, Kruize Zita, van Nuenen Ad C., van Dort Karel A., Takkenberg R. Bart, Reesink Hendrik W., Kootstra Neeltje A. Plasma MicroRNA Levels Are Associated With Hepatitis B e Antigen Status and Treatment Response in Chronic Hepatitis B Patients Journal of infectious diseases 2017;215 (9):1421-1429 [PubMed]
  • Jansen Louis, Welkers Matthijs R. A., van Dort Karel A., Takkenberg R. Bart, Lopatin Uri, Zaaijer Hans L., de Jong Menno D., Reesink Hendrik W., Kootstra Neeltje A. Viral minority variants in the core promoter and precore region identified by deep sequencing are associated with response to peginterferon and adefovir in HBeAg negative chronic hepatitis B patients Antiviral research 2017;145:87-95 [PubMed]

2016

  • Jansen L., Kootstra Neeltje A., van Dort Karel A., Takkenberg R. Bart, Reesink Hendrik W., Zaaijer Hans L. Hepatitis B Virus Pregenomic RNA Is Present in Virions in Plasma and Is Associated With a Response to Pegylated Interferon Alfa-2a and Nucleos(t)ide Analogues Journal of infectious diseases 2016;213 (2):224-232 [PubMed]
  • Stelma F., Jansen L., Sinnige M. J., van Dort K. A., Takkenberg R. B., Janssen H. L. A., Reesink H. W., Kootstra N. A. HLA-C and KIR combined genotype as new response marker for HBeAg-positive chronic hepatitis B patients treated with interferon-based combination therapy Journal of viral hepatitis 2016;23 (8):652-659 [PubMed]
  • Willemse S. B., Jansen L., de Niet A., Sinnige M. J., Takkenberg R. B., Verheij J., Kootstra N. A., Reesink H. W. Intrahepatic IP-10 mRNA and plasma IP-10 levels as response marker for HBeAg-positive chronic hepatitis B patients treated with peginterferon and adefovir Antiviral research 2016;131:148-155 [PubMed]
  • de Niet Annikki, Stelma Femke, Jansen Louis, Sinnige Marjan J., Remmerswaal Ester B. M., Takkenberg R. Bart, Kootstra Neeltje A., Reesink Hendrik W., van Lier Rene A. W., van Leeuwen Ester M. M. Restoration of T cell function in chronic hepatitis B patients upon treatment with interferon based combination therapy Journal of hepatology 2016;64 (3):539-546 [PubMed]
  • D'Agnolo Hedwig M. A., Kievit Wietske, Takkenberg R. Bart, Riaño Ioana, Bujanda Luis, Neijenhuis Myrte K., Brunenberg Ellen J. L., Beuers Ulrich, Banales Jesus M., Drenth Joost P. H. Ursodeoxycholic acid in advanced polycystic liver disease: A phase 2 multicenter randomized controlled trial Journal of hepatology 2016;65 (3):601-607 [PubMed]

2015

  • van Lent Anja Ursula, Takkenberg R. Bart, van Eeden Susanne, Mulder Chris, Beuers Ulrich Chronic diarrhea because of villous atrophy unrelated to celiac disease Endoscopy 2015;47 (Suppl. 1 UCTN):E71-E72 [PubMed]
  • Stelma Femke, de Niet Annikki, Tempelmans Plat-Sinnige Marjan J., Jansen Louis, Takkenberg R. Bart, Reesink Hendrik W., Kootstra Neeltje A., van Leeuwen Ester M. M. Natural Killer Cell Characteristics in Patients With Chronic Hepatitis B Virus (HBV) Infection Are Associated With HBV Surface Antigen Clearance After Combination Treatment With Pegylated Interferon Alfa-2a and Adefovir Journal of infectious diseases 2015;212 (7):1042-1051 [PubMed]

2014

  • van Rhijn Bram D., Warners Marijn J., Curvers Wouter L., van Lent Anja U., Bekkali Noor L., Takkenberg R. Bart, Kloek Jaap J., Bergman Jacques J. G. H. M., Fockens Paul, Bredenoord Albert J. Evaluating the endoscopic reference score for eosinophilic esophagitis: moderate to substantial intra- and interobserver reliability Endoscopy 2014;46 (12):1049-1055 [PubMed]
  • de Niet Annikki, Jansen Louis, Zaaijer Hans L., Klause Ursula, Takkenberg Bart, Janssen Harry L. A., Chu Tom, Petric Rosemary, Reesink Hendrik W. Experimental HBsAg/anti-HBs complex assay for prediction of HBeAg loss in chronic hepatitis B patients treated with pegylated interferon and adefovir Antiviral therapy 2014;19 (3):259-267 [PubMed]
  • Jansen Louis, de Niet Annikki, Stelma Femke, van Iperen Erik P. A., van Dort Karel A., Tempelmans Plat-Sinnige Marjan J., Takkenberg R. Bart, Chin Daniel J., Zwinderman A. H. Koos, Lopatin Uri, Kootstra Neeltje A., Reesink Hendrik W. HBsAg loss in patients treated with peginterferon alfa-2a and adefovir is associated with SLC16A9 gene variation and lower plasma carnitine levels Journal of hepatology 2014;61 (4):730-737 [PubMed]

2013

  • Takkenberg R. Bart, Jansen Louis, de Niet Annikki, Zaaijer Hans L., Weegink Christine J., Terpstra Valeska, Dijkgraaf Marcel G. W., Molenkamp Richard, Jansen Peter L. M., Koot Maarten, Rijckborst Vincent, Janssen Harry L. A., Beld Marcel G. H. M., Reesink Hendrik W. Baseline hepatitis B surface antigen (HBsAg) as predictor of sustained HBsAg loss in chronic hepatitis B patients treated with pegylated interferon-α2a and adefovir Antiviral therapy 2013;18 (7):895-904 [PubMed]
  • de Niet A., de Bruijne J., Plat-Sinnige M. J. Tempelmans, Takkenberg R. B., van Lier R. A. W., Reesink H. W., van Leeuwen E. M. M. Upregulation of CXCR3 expression on CD8+ T cells due to the pervasive influence of chronic hepatitis B and C virus infection Human immunology 2013;74 (8):899-906 [PubMed]

2012

  • Dik Kathelijne, de Bruijne Joep, Takkenberg R. Bart, Roelofs Joris J., Tempelmans Marjan J., Dijkgraaf Marcel G. W., Gelderblom Huub C., Reesink Henk W., Meijers Joost C. M., Jansen Peter L., Levi Marcel Factor XIII Val34Leu mutation accelerates the development of fibrosis in patients with chronic hepatitis B and C Hepatology research 2012;42 (7):668-676 [PubMed]
  • Dik Kathelijne, de Bruijne Joep, Takkenberg R. Bart, Roelofs Joris J., Tempelmans Marjan J., Dijkgraaf Marcel G. W., Gelderblom Huub C., Reesink Henk W., Meijers Joost C. M., Jansen Peter L., Levi Marcel Factor XIII Val34Leu mutation and liver fibrosis rate in viral hepatitis Reply Hepatology research 2012;42 (11):1154-1155 [PubMed]
  • de Niet A., Takkenberg R. B., Benayed R., Riley-Gillis B., Weegink C. J., Zaaijer H. L., Koot M., Jansen P. L. M., Beld M. G. H. M., Lopatin U., Reesink H. W. Genetic variation in IL28B and treatment outcome in HBeAg-positive and -negative chronic hepatitis B patients treated with Peg interferon alfa-2a and adefovir Scandinavian journal of gastroenterology 2012;47 (4):475-481 [PubMed]
  • Takkenberg R. B., Menting S., Beld M. G. H. M. Validation of a sensitive and specific real-time PCR for detection and quantitation of hepatitis B virus covalently closed circular DNA in plasma of chronic hepatitis B patients Methods in molecular biology (Clifton, N.J.) 2012;903:113-128 [PubMed]

2011

  • Takkenberg Bart, Terpstra Valeska, Zaaijer Hans, Weegink Christine, Dijkgraaf Marcel, Jansen Peter, Beld Marcel, Reesink Hendrik Intrahepatic response markers in chronic hepatitis B patients treated with peginterferon alpha-2a and adefovir Journal of gastroenterology and hepatology 2011;26 (10):1527-1535 [PubMed]
  • Takkenberg R. Bart Markers of response in chronic hepatitis B patients treated with a combination of peginterferon-alfa 2a and adefovir dipivoxil 2011. 151p. ISBN 9789090263045. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Jansen P. L. M., Zaaijer H. L.; Co-supervisors: Reesink H. W., Beld M. G. H. M.)

2010

  • Takkenberg R. Bart, Zaaijer Hans L., Menting Sandra, Weegink Christine J., Terpstra Valeska, Cornelissen Marion, Dijkgraaf Marcel G. W., Jansen Peter L. M., Reesink Hendrik W., Beld Marcel G. H. M. Detection of hepatitis B virus covalently closed circular DNA in paraffin-embedded and cryo-preserved liver biopsies of chronic hepatitis B patients European journal of gastroenterology & hepatology 2010;22 (8):952-960 [PubMed]
  • Takkenberg R. B., Weegink C. J., Zaaijer H. L., Reesink H. W. New developments in antiviral therapy for chronic hepatitis B Vox sanguinis 2010;98 (4):481-494 [PubMed]

2009

  • Takkenberg R. B., Zaaijer Hans L., ten Cate David F., Biemond Bart J., Jansen Peter L. M., Reesink Henk W. Reactivatie van het hepatitis B-virus bij patiënten met een hematologische maligniteit Nederlands tijdschrift voor geneeskunde 2009;153 (19):926-931 [PubMed]
  • Zaaijer H. L., Takkenberg R. B., Weegink C. J., Rebers S. P. H., Menting S., Reesink H. W., Schinkel J., Molenkamp R. Susceptibility of hepatitis B virus to lamivudine restored by resistance to adefovir Journal of medical virology 2009;81 (3):413-416 [PubMed]
  • Takkenberg R. B., Zaaijer H. L., Molenkamp R., Menting S., Terpstra V., Weegink C. J., Dijkgraaf M. G. W., Jansen P. L. M., Reesink H. W., Beld M. G. H. M. Validation of a sensitive and specific real-time PCR for detection and quantitation of hepatitis B virus covalently closed circular DNA in plasma of chronic hepatitis B patients Journal of medical virology 2009;81 (6):988-995 [PubMed]

2008

  • Takkenberg Bart, de Bruijne Joep, Weegink Christine, Jansen Peter, Reesink Hendrik Novel therapies in hepatitis B and C Current gastroenterology reports 2008;10 (1):81-90 [PubMed]

2005

  • Takkenberg R. B., Vrouenraets B. C., van Geel A. N., Nieweg O. E., Noorda E. M., Eggermont A. M. M., Kroon B. B. R. Palliative isolated limb perfusion for advanced limb disease in stage IV melanoma patients Journal of surgical oncology 2005;91 (2):107-111 [PubMed]

2004

  • Noorda Eva M., Takkenberg Bart, Vrouenraets Bart C., Nieweg Omgo E., van Geel Bert N., Eggermont Alexander M. M., Hart Guus A. M., Kroon Bin B. R. Isolated limb perfusion prolongs the limb recurrence-free interval after several episodes of excisional surgery for locoregional recurrent melanoma Annals of surgical oncology 2004;11 (5):491-499 [PubMed]

1991

  • Takkenberg B., Endert E., van Ingen H. E., Ackermans M. Improved method for the determination of serotonin in plasma by high-performance liquid chromatography using on-line sample pre-treatment Journal of chromatography. A 1991;565 (1-2):430-435 [PubMed]