Prof. E. Lutgens PhD publications

Publications Prof. PhD E. Lutgens

Position: Full Professor
Main activities: Research
Specialisation: Vascular immunopathology
Focus of research: My research over the last 5 years has focused on how modulation of co-stimulatory pathways and the CD40-CD40L dyad in particular are able to mediate vascular disease, with a major focus on how immune cells (inter)act and which phenotype they display.
Within my laboratory, 3 major research lines exist:
1. Cell-type specific actions of CD40-CD40L signaling.
We performed bone marrow transplantations and adoptive transfer studies with platelets and dendritic cells and found that leukocyte (J Exp Med 2010) and dendritic cell CD40 and platelet CD40L (Blood 2011) are crucial in mediating atherosclerosis via different immune modulatory pathways. In addition, we generated CD40Lfl/fl and CD40fl/fl mice which are currently backcrossed with an array of cell-type specific Cre mice, which will give us additional information on the exact role and communication of the different CD40(L) expressing cell-types.
2. Identification of CD40-CD40L signal transduction pathways in atherosclerosis.
CD40-/- mice received a CD40 transgene with mutations in the respective TRAF-binding sites. Apoe-/- mice deficient in the CD40-TRAF2/3/5 binding site developed normal levels of atherosclerosis, while mice deficient in CD40-TRAF6 signaling hardly developed atherosclerosis, and contained immune regulatory monocytes/macrophages (J Exp Med 2010). We are currently investigating how the different CD40-TRAF interactions in different cell-types and pathologies mediate immune cell phenotype and interactions.
Based on these results, I have, in collaboration with Dr. G. Nicholaes (University of Maastricht), developed and tested small compounds directed against the CD40 binding pocket of TRAF6. Two of these compounds are able to successfully inhibit atherosclerosis development, and I have filed a patent.
3. Identification of the role of other co-stimulatory molecules in atherosclerosis.
We are currently investigating the role of CD27/CD70, GITR and CTLA4 in atherosclerosis. We are analysing plaque extent, phenotype and the immunological status of arteries and lymphoid organs of the respective knock-out mice and inhibitors.
Recent interests in the lab are obesity (ATVB 2011), and HSPCs (this grant). I have invested time and efforts in the last 2 years to integrate these scientific fields in my laboratory. We performed a detailed screening on the role of CD40L in obesity, as well as in HSPC biology. These studies are currently submitted to expert journals.

Amsterdam UMC Research Institutes

AMC departments

Medical Biochemistry

All publications

2020

Poels Kikkie, van Leent Mandy M. T., Reiche Myrthe E., Kusters Pascal J. H., Huveneers Stephan, de Winther Menno P. J., Mulder Willem J. M., Lutgens Esther, Seijkens Tom T. P. Antibody-Mediated Inhibition of CTLA4 Aggravates Atherosclerotic Plaque Inflammation and Progression in Hyperlipidemic Mice Cells 2020;9 (9) [PubMed]
Legein Bart, Janssen Edith M., Theelen Thomas L., Gijbels Marion J., Walraven Joep, Klarquist Jared S., Hennies Cassandra M., Wouters Kristiaan, Seijkens Tom T. P., Wijnands Erwin, Sluimer Judith C., Lutgens Esther, Zenke Martin, Hildner Kai, Biessen Erik A. L., Temmerman Lieve Author Correction: Ablation of CD8α+ dendritic cell mediated cross-presentation does not impact atherosclerosis in hyperlipidemic mice (Scientific Reports, (2015), 5, 1, (15414), 10.1038/srep15414) Scientific reports 2020;10 (1) [PubMed]
Santovito Donato, Egea Virginia, Bidzhekov Kiril, Natarelli Lucia, Mourão André, Blanchet Xavier, Wichapong Kanin, Aslani Maria, Brunβen Coy, Horckmans Michael, Hristov Michael, Geerlof Arie, Lutgens Esther, Daemen Mat J. A. P., Hackeng Tilman, Ries Christian, Chavakis Triantafyllos, Morawietz Henning, Naumann Ronald, Hundelshausen Philipp Von, Steffens Sabine, Duchêne Johan, Megens Remco T. A., Sattler Michael, Weber Christian Autophagy unleashes noncanonical microRNA functions Autophagy 2020;16 (12):2294-2296 [PubMed]
Lutgens Esther, Seijkens Tom T. P. Cancer patients receiving immune checkpoint inhibitor therapy are at an increased risk for atherosclerotic cardiovascular disease Journal for immunotherapy of cancer 2020;8 (1) [PubMed]
Daub Steffen, Lutgens Esther, Münzel Thomas, Daiber Andreas CD40/CD40L and related signaling pathways in cardiovascular health and disease—The pros and cons for cardioprotection International journal of molecular sciences 2020;21 (22):1-18 [PubMed]
Dweck Marc R., Maurovich-Horvat P. l, Leiner Tim, Cosyns Bernard, Fayad Zahi A., Gijsen Frank J. H., van der Heiden Kim, Kooi M. Eline, Maehara Akiko, Muller James E., Newby David E., Narula Jagat, Pontone Gianluca, Regar Evelyn, Serruys Patrick W., van der Steen Antonius F. W., Stone Peter H., Waltenberger Johannes L., Yuan Chun, Evans Paul C., Lutgens Esther, Wentzel Jolanda J., Bäck Magnus Contemporary rationale for non-invasive imaging of adverse coronary plaque features to identify the vulnerable patient: A Position Paper from the European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology and the European Association of Cardiovascular Imaging European heart journal cardiovascular Imaging 2020;21 (11):1177-1183 [PubMed]
Genzel Lisa, Adan Roger, Berns Anton, van den Beucken Jeroen J. J. P., Blokland Arjan, Boddeke Erik H. W. G. M., Bogers Willy M., Bontrop Ronald, Bulthuis R., Bousema Teun, Clevers Hans, Coenen Tineke C. J. J., van Dam Anne-Marie, Deen Peter M. T., van Dijk K. W., Eggen Bart J. L., Elgersma Ype, Erdogan Izel, Englitz Bernhard, Fentener van Vlissingen J. Martje, la Fleur Susanne, Fouchier Ron, Fitzsimons Carlos P., Frieling Wilbert, Haagmans Bart, Heesters Balthasar A., Henckens Marloes J. A. G., Herfst Sander, Hol Elly, van den Hove Daniel, de Jonge Marien I., Jonkers Jos, Joosten Leo A. B., Kalsbeek Andries, Kamermans Maarten, Kampinga Harm H., Kas Martien J., Keijer Jaap, Kersten Sander, Kiliaan Amanda J., Kooij Taco W. A., Kooijman Sander, Koopman Werner J. H., Korosi Aniko, Krugers Harm J., Kuiken Thijs, Kushner Steven A., Langermans Jan A. M., Lesscher Heidi M. B., Lucassen Paul J., Lutgens Esther, Netea Mihai G., Noldus Lucas P. J. J., van der Meer Jos W. M., Meye Frank J., Mul Joram D., van Oers Kees, Olivier Jocelien D. A., Pasterkamp R. Jeroen, Philippens Ingrid H. C. H. M., Prickaerts Jos, Pollux B. J. A., Rensen Patrick C. N., van Rheenen Jacco, van Rij Ronald P., Ritsma Laila, Rockx Barry.H. G., Roozendaal Benno, van Schothorst Evert M., Stittelaar K., Stockhofe Norbert, Swaab Dick F., de Swart Rik L., Vanderschuren Louk J. M. J., de Vries Taco J., de Vrij Femke, van Wezel Richard, Wierenga Corette J., Wiesmann Maximilian, Willuhn Ingo, de Zeeuw Chris I., Homberg Judith R. Erratum: How the COVID-19 pandemic highlights the necessity of animal research (Current Biology (2020) 30(18) (R1014–R1018), (S0960982220311842), (10.1016/j.cub.2020.08.030)) Current biology 2020;30 (21):4328 [PubMed]
Shami Annelie, Atzler Dorothee, Bosmans Laura A., Winkels Holger, Meiler Svenja, Lacy Michael, van Tiel Claudia, Ta Megens Remco, Nitz Katrin, Baardman Jeroen, Kusters Pascal, Seijkens Tom, Buerger Christina, Janjic Aleksandar, Riccardi Carlo, Edsfeldt Andreas, Monaco Claudia, Daemen Mat, de Winther Menno P. J., Nilsson Jan, Weber Christian, Gerdes Norbert, Gonçalves Isabel, Lutgens Esther Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans European heart journal 2020;41 (31):2938-2948 [PubMed]
Genzel Lisa, Adan Roger, Berns Anton, van den Beucken Jeroen, Blokland Arjan, Boddeke Erik H. W. G. M., Bogers Willy M., Bontrop Ronald, Bulthuis R., Bousema Teun, Clevers Hans, Coenen Tineke C. J. J., Dam Anne-Marie van, Deen Peter M. T., van Dijk K. W., Eggen Bart J. L., Elgersma Ype, Erdogan Izel, Englitz Bernard, Fentener van Vlissingen J. Martje, la Fleur Susanne, Fouchier Ron, Fitzsimons Carlos P., Frieling Wilbert, Haagmans Bart, Heesters Balthasar A., Henckens Marloes, Herfst Sander, Hol Elly, van den Hove Daniel, de Jonge Marien I., Jonkers Jos, Joosten Leo A. B., Kalsbeek Andries, Kamermans Maarten, Kampinga Harm H., Kas Martien J., Keijer J., Kersten Sander, Kiliaan Amanda J., Kooij Taco W. A., Kooijman Sander, Koopman Werner J. H., Korosi Aniko, Krugers Harm J., Kuiken Thijs, Kushner Steven A., Langermans Jan A. M., Lesscher Heidi, Lucassen Paul J., Lutgens Esther, Netea Mihai G., Noldus Lucas P. J. J., van der Meer Jos W. M., Meye Frank J., Mul Joram D., van Oers Kees, Olivier Jocelien D. A., Pasterkamp R. Jeroen, Philippens Ingrid H. C. H. M., Prickaerts Jos, Pullox Bart J. A., Rensen Patrick C. N., van Rheenen Jacco, van Rij Ronald P., Ritsma Laila, Rockx Barry.H. G., Roozendaal Benno, van Schothorst Evert M., Stittelaar K., Stockhofe Norbert, Swaab Dick F., de Swart Rik L., Vanderschuren Louk J. M. J., de Vries Taco, de Vrij Femke, van Wezel Richard, Wierenga Corette J., Wiesmann Maximilian, Willuhn Ingo, de Zeeuw Chris I., Homberg Judith R. How the COVID-19 pandemic highlights the necessity of animal research Current biology 2020;30 (18):R1014-R1018 [PubMed]
Poels Kikkie, van Leent Mandy M. T., Boutros Celine, Tissot Hubert, Roy S. verine, Meerwaldt Anu E., Toner Yohana C. A., Reiche Myrthe E., Kusters Pascal J. H., Malinova Tsveta, Huveneers Stephan, Kaufman Audrey E., Mani Venkatesh, Fayad Zahi A., de Winther Menno P. J., Marabelle Aurelien, Mulder Willem J. M., Robert Caroline, Seijkens Tom T. P., Lutgens Esther Immune Checkpoint Inhibitor Therapy Aggravates T Cell–Driven Plaque Inflammation in Atherosclerosis JACC: CardioOncology 2020;2 (4):599-610
Poels Kikkie, Schnitzler Johan G., Waissi Farahnaz, Levels Johannes H. M., Stroes Erik S. G., Daemen Mat J. A. P., Lutgens Esther, Pennekamp Anne-Marije, de Kleijn Dominique P. V., Seijkens Tom T. P., Kroon Jeffrey Inhibition of PFKFB3 Hampers the Progression of Atherosclerosis and Promotes Plaque Stability Frontiers in cell and developmental biology 2020;8 [PubMed]
van der Vorst Emiel P. C., Daissormont Isabelle, Aslani Maria, Seijkens Tom, Wijnands Erwin, Lutgens Esther, Duchene Johan, Santovito Donato, Döring Yvonne, Halvorsen Bente, Aukrust Pal, Weber Christian, Höpken Uta E., Biessen Erik A. L. Interruption of the CXCL13/CXCR5 Chemokine Axis Enhances Plasma IgM Levels and Attenuates Atherosclerosis Development Thrombosis and haemostasis 2020;120 (2):344-347 [PubMed]
Baardman Jeroen, Verberk Sanne G. S., van der Velden Saskia, Gijbels Marion J. J., van Roomen Cindy P. P. A., Sluimer Judith C., Broos Jelle Y., Griffith Guillermo R., Prange Koen H. M., van Weeghel Michel, Lakbir Soufyan, Molenaar Douwe, Meinster Elisa, Neele Annette E., Kooij Gijs, de Vries Helga E., Lutgens Esther, Wellen Kathryn E., de Winther Menno P. J., van den Bossche Jan Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques Nature communications 2020;11 (1) [PubMed]
Depuydt Marie A. C., Prange Koen H. M., Slenders Lotte, Örd Tiit, Elbersen Danny, Boltjes Arjan, de Jager Saskia C. A., Asselbergs Folkert W., de Borst Gert J., Aavik Einari, Lönnberg Tapio, Lutgens Esther, Glass Christopher K., den Ruijter Hester M., Kaikkonen Minna U., Bot Ilze, Slütter Bram, van der Laan Sander W., Yla-Herttuala Seppo, Mokry Michal, Kuiper Johan, de Winther Menno P. J., Pasterkamp Gerard Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics Circulation research 2020;127 (11):1437-1455 [PubMed]
Remie Carlijn M. E., Roumans Kay H. M., Moonen Michiel P. B., Connell Niels J., Havekes Bas, Mevenkamp Julian, Lindeboom Lucas, de Wit Vera H. W., van de Weijer Tineke, Aarts Suzanne A. B. M., Lutgens Esther, Schomakers Bauke V., Elfrink Hyung L., Zapata-Pérez Rubén, Houtkooper Riekelt H., Auwerx Johan, Hoeks Joris, Schrauwen-Hinderling Vera B., Phielix Esther, Schrauwen Patrick Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans American journal of clinical nutrition 2020;112 (2):413-426 [PubMed]
Santovito Donato, Egea Virginia, Bidzhekov Kiril, Natarelli Lucia, Mourão André, Blanchet Xavier, Wichapong Kanin, Aslani Maria, Brunßen Coy, Horckmans Michael, Hristov Michael, Geerlof Arie, Lutgens Esther, Daemen Mat J. A. P., Hackeng Tilman, Ries Christian, Chavakis Triantafyllos, Morawietz Henning, Naumann Ronald, von Hundelshausen Philipp, Steffens Sabine, Duchêne Johan, Megens Remco T. A., Sattler Michael, Weber Christian Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis Science translational medicine 2020;12 (546) [PubMed]
Baardman Jeroen, Lutgens Esther Regulatory T cell metabolism in atherosclerosis Metabolites 2020;10 (7):1-15 [PubMed]
Lutgens Esther rs1883832: a CD40 single-nucleotide polymorphism for predicting coronary heart disease in humans Cardiovascular research 2020;116 (6):1095-1096 [PubMed]
Schnitzler Johan G., Poels Kikkie, Stiekema Lotte C. A., Yeang Calvin, Tsimikas Sotirios, Kroon Jeffrey, Stroes Erik S. G., Lutgens Esther, Seijkens Tom T. P. Short-term regulation of hematopoiesis by lipoprotein(a) results in the production of pro-inflammatory monocytes International journal of cardiology 2020;315:81-85 [PubMed]
Bosmans Laura A., Bosch Lena, Kusters Pascal J. H., Lutgens Esther, Seijkens Tom T. P. The CD40-CD40L Dyad as Immunotherapeutic Target in Cardiovascular Disease Journal of cardiovascular translational research 2020 [PubMed]
Bosch Lena, de Haan Judith J., Seijkens Tom T. P., van Tiel Claudia M., Brans Maike A. D., Pasterkamp Gerard, Lutgens Esther, de Jager Saskia C. A. The therapeutic potential of targeting CD40-TRAF6 pathway in cardiovascular Diseases International journal of cardiology 2020;300:220 [PubMed]

2019

Bosch Lena, de Haan Judith J., Seijkens Tom T. P., van Tiel Claudia M., Brans Maike A. D., Pasterkamp Gerard, Lutgens Esther, de Jager Saskia C. A. Corrigendum to ‘Small molecule-mediated inhibition of CD40-TRAF6 reduces adverse cardiac remodelling in pressure overload induced heart failure’ [Int. J. Cardiol., Volume 279, 15 March 2019, Pages 141-144](S0167527318325531)(10.1016/j.ijcard.2018.12.076) International journal of cardiology 2019;293:297 [PubMed]
Reiche Myrthe E., den Toom Myrthe, Willemsen Lisa, van Os Bram, Gijbels Marion J. J., Gerdes Norbert, Aarts Suzanne A. B. M., Lutgens Esther Deficiency of T cell CD40L has minor beneficial effects on obesity-induced metabolic dysfunction BMJ open diabetes research and care 2019;7 (1) [PubMed]
Seijkens Tom T. P., Poels Kikkie, Meiler Svenja, van Tiel Claudia M., Kusters Pascal J. H., Reiche Myrthe, Atzler Dorothee, Winkels Holger, Tjwa Marc, Poelman Hessel, Slütter Bram, Kuiper Johan, Gijbels Marion, Kuivenhoven Jan Albert, Matic Ljubica Perisic, Paulsson-Berne Gabrielle, Hedin Ulf, Hansson G. ran K., Nicolaes Gerry A. F., Daemen Mat J. A. P., Weber Christian, Gerdes Norbert, de Winther Menno P. J., Lutgens Esther Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8 + T cell-mediated macrophage death European heart journal 2019;40 (4):372-382 [PubMed]
Thiem Kathrin, Hoeke Geerte, Zhou Enchen, Hijmans Anneke, Houben Tom, Boels Margien G., Mol Isabel M., Lutgens Esther, Shiri-Sverdlov Ronit, Bussink Johan, Kanneganti Thirumala D., Boon Mariëtte R., Stienstra Rinke, Tack Cees J., Rensen Patrick C. N., Netea Mihai G., Berbée Jimmy F. P., van Diepen Janna A. Deletion of haematopoietic Dectin-2 or CARD9 does not protect from atherosclerosis development under hyperglycaemic conditions Diabetes & vascular disease research 2019 [PubMed]
Thiem Kathrin, Hoeke Geerte, van den Berg Susan, Hijmans Anneke, Jacobs Cor W. M., Zhou Enchen, Mol Isabel M., Mouktaroudi Maria, Bussink Johan, Kanneganti Thirumala D., Lutgens Esther, Stienstra Rinke, Tack Cees J., Netea Mihai G., Rensen Patrick C. N., Berbée Jimmy F. P., van Diepen Janna A. Deletion of hematopoietic Dectin-2 or CARD9 does not protect against atherosclerotic plaque formation in hyperlipidemic mice Scientific reports 2019;9 (1) [PubMed]
Aarts Suzanne, Reiche Myrthe, den Toom Myrthe, Gijbels Marion, Beckers Linda, Gerdes Norbert, Lutgens Esther Depletion of CD40 on CD11c+ cells worsens the metabolic syndrome and ameliorates hepatic inflammation during NASH Scientific reports 2019;9 (1):14702 [PubMed]
Schilperoort Maaike, van den Berg Rosa, Bosmans Laura A., van Os Bram W., Dollé Martijn E. T., Smits Noortje A. M., Guichelaar Teun, van Baarle Debbie, Koemans Lotte, Berbée Jimmy F. P., Deboer Tom, Meijer Johanna H., de Vries Margreet R., Vreeken Dianne, van Gils Janine M., Willems van Dijk Ko, van Kerkhof Linda W. M., Lutgens Esther, Biermasz Nienke R., Rensen Patrick C. N., Kooijman Sander Disruption of circadian rhythm by alternating light-dark cycles aggravates atherosclerosis development in APOE*3-Leiden.CETP mice Journal of pineal research 2019 [PubMed]
Chen Pei-Yu, Qin Lingfeng, Li Guangxin, Wang Zheng, Dahlman James E., Malagon-Lopez Jose, Gujja Sharvari, Cilfone Nicholas A., Kauffman Kevin J., Sun Lele, Sun Hongye, Zhang Xinbo, Aryal Binod, Canfran-Duque Alberto, Liu Rebecca, Kusters Pascal, Sehgal Alfica, Jiao Yang, Anderson Daniel G., Gulcher Jeffrey, Fernandez-Hernando Carlos, Lutgens Esther, Schwartz Martin A., Pober Jordan S., Chittenden Thomas W., Tellides George, Simons Michael Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis Nature Metabolism 2019;1 (9):912-926 [PubMed]
Lutgens Esther Epigenetic Quenching of VSMC Inflammation in CVD: H3K9me2 in Control Arteriosclerosis, thrombosis, and vascular biology 2019;39 (11):2199-2200 [PubMed]
Kusters P.J.H. Evaluating the therapeutic potential of CD40 in low-grade chronic inflammation 2019. 261p. ISBN 9789463755894. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Lutgens E., de Winther M.P.J.; Co-supervisors: Seijkens T. T. P., Neele A.E.)
Silvestre-Roig Carlos, Braster Quinte, Wichapong Kanin, Lee Ernest Y., Teulon Jean Marie, Berrebeh Nihel, Winter Janine, Adrover José M., Santos Giancarlo Santiago, Froese Alexander, Lemnitzer Patricia, Ortega-Gómez Almudena, Chevre Raphael, Marschner Julian, Schumski Ariane, Winter Carla, Perez-Olivares Laura, Pan Chang, Paulin Nicole, Schoufour Tom, Hartwig Helene, González-Ramos Silvia, Kamp Frits, Megens Remco T. A., Mowen Kerri A., Gunzer Matthias, Maegdefessel Lars, Hackeng Tilman, Lutgens Esther, Daemen Mat, von Blume Julia, Anders Hans-Joachim, Nikolaev Viacheslav O., Pellequer Jean-Luc, Weber Christian, Hidalgo Andrés, Nicolaes Gerry A. F., Wong Gerard C. L., Soehnlein Oliver Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death Nature 2019;569 (7755):236-240 [PubMed]
Centa Monica, Jin Hong, Hofste Lisa, Hellberg Sanna, Busch Albert, Baumgartner Roland, Verzaal Nienke J., Lind Enoksson Sara, Perisic Matic Ljubica, Boddul Sanjay V., Atzler Dorothee, Li Daniel Y., Sun Changyan, Hansson G. ran K., Ketelhuth Daniel F. J., Hedin Ulf, Wermeling Fredrik, Lutgens Esther, Binder Christoph J., Maegdesfessel Lars, Malin Stephen G. Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability Circulation 2019;139 (21):2466-2482 [PubMed]
Kuipers Eline N., Kantae Vasudev, Eveleens Maarse Boukje C., van den Berg Susan M., van Eenige Robin, Nahon Kimberly J., Reifel-Miller Anne, Coskun Tamer, de Winther Menno P. J., Lutgens Esther, Kooijman Sander, Harms Amy C., Hankemeier Thomas, van der Stelt Mario, Rensen Patrick C. N., Boon Mariëtte R. High fat diet increases circulating endocannabinoids accompanied by increased synthesis enzymes in adipose tissue Frontiers in physiology 2019;10 (JAN) [PubMed]
Tuñón José, Badimón Lina, Bochaton-Piallat Marie-Luce, Cariou Bertrand, Daemen Mat J., Egido Jesus, Evans Paul C., Hoefer Imo E., Ketelhuth Daniel F. J., Lutgens Esther, Matter Christian M., Monaco Claudia, Steffens Sabine, Stroes Erik, Vindis C. cile, Weber Christian, Bäck Magnus Identifying the anti-inflammatory response to lipid lowering therapy: a position paper from the working group on atherosclerosis and vascular biology of the European Society of Cardiology Cardiovascular research 2019;115 (1):10-19 [PubMed]
Ketelhuth Daniel F. J., Lutgens Esther, Bäck Magnus, Binder Christoph J., van den Bossche Jan, Daniel Carolin, Dumitriu Ingrid E., Hoefer Imo, Libby Peter, O'Neill Luke, Weber Christian, Evans Paul C. Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology Cardiovascular research 2019;115 (9):1385-1392 [PubMed]
Lutgens Esther, Atzler Dorothee, Döring Yvonne, Duchene Johan, Steffens Sabine, Weber Christian Immunotherapy for cardiovascular disease European heart journal 2019;40 (48):3937-3946 [PubMed]
Lacy Michael, Atzler Dorothee, Liu Rongqi, de Winther Menno, Weber Christian, Lutgens Esther Interactions between dyslipidemia and the immune system and their relevance as putative therapeutic targets in atherosclerosis Pharmacology & therapeutics 2019;193:50-62 [PubMed]
Aarts Suzanne A. BM, Seijkens Tom T. P., Kusters Pascal J. H., van Tiel Claudia M., Reiche Myrthe E., den Toom Myrthe, Beckers Linda, van Roomen Cindy P. AA, de Winther Menno P. J., Kooij Gijs, Lutgens Esther Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis Journal of pathology 2019;247 (4):471-480 [PubMed]
Baardman Jeroen Metabolic orchestration of macrophages in disease 2019. 165p. ISBN 9789463755467. [UvA Dissertations Online] University of Amsterdam. (Supervisors: de Winther M. P. J. , Lutgens E.; Co-supervisors: Van den Bossche J. , Gijbels M. J. J.)
Beldman Thijs J., Malinova Tsveta S., Desclos Emilie, Grootemaat Anita E., Misiak Aresh L. S., van der Velden Saskia, van Roomen Cindy P. A. A., Beckers Linda, van Veen Henk A., Krawczyk Przemyslaw M., Hoebe Ron A., Sluimer Judith C., Neele Annette E., de Winther Menno P. J., van der Wel Nicole N., Lutgens Esther, Mulder Willem J. M., Huveneers Stephan, Kluza Ewelina Nanoparticle-Aided Characterization of Arterial Endothelial Architecture during Atherosclerosis Progression and Metabolic Therapy ACS nano 2019;13 (12):13759-13774 [PubMed]
Braster Quinte Neutrophil-derived mediators in cardiometabolic inflammation 2019. 128p. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Lutgens E. , Daemen M. J. A. P.; Co-supervisor: Söhnlein O.)
Neidhart Michel, Pajak Agnieszka, Laskari Katerina, Riksen Niels P., Joosten Leo A. B., Netea Mihai G., Lutgens Esther, Stroes Eric S. G., Ciurea Adrian, Distler Oliver, Grigorian Mariam, Karouzakis Emmanuel Oligomeric S100A4 Is Associated With Monocyte Innate Immune Memory and Bypass of Tolerance to Subsequent Stimulation With Lipopolysaccharides Frontiers in immunology 2019;10:791 [PubMed]
Willemsen Lisa, Neele Annette E., van der Velden Saskia, Prange Koen H. M., den Toom Myrthe, van Roomen Cindy P. A. A., Reiche Myrthe E., Griffith Guillermo R., Gijbels Marion J. J., Lutgens Esther, de Winther Menno P. J. Peritoneal macrophages have an impaired immune response in obesity which can be reversed by subsequent weight loss BMJ open diabetes research and care 2019;7 (1) [PubMed]
Wichapong Kanin, Poelman Hessel, Ercig Bogac, Hrdinova Johana, Liu Xiaosong, Lutgens Esther, Nicolaes Gerry A. F. Rational modulator design by exploitation of protein-protein complex structures Future Medicinal Chemistry 2019;11 (9):1015-1033 [PubMed]
Bosch Lena, de Haan Judith, Seijkens Tom, van Tiel Claudia, Brans Maike, Pasterkamp Gerard, Lutgens Esther, de Jager Saskia Small molecule-mediated inhibition of CD40-TRAF6 reduces adverse cardiac remodelling in pressure overload induced heart failure International journal of cardiology 2019;279:141-144 [PubMed]
Hollander Maurits R., Jansen Matthijs F., Hopman Luuk H. G. A., Dolk Edward, van de Ven Peter M., Knaapen Paul, Horrevoets Anton J., Lutgens Esther, van Royen Niels Stimulation of Collateral Vessel Growth by Inhibition of Galectin 2 in Mice Using a Single-Domain Llama-Derived Antibody Journal of the American Heart Association 2019;8 (20):e012806 [PubMed]
de Winther Menno P. J., Lutgens Esther The link between hematopoiesis and atherosclerosis New England journal of medicine 2019;380 (19):1869-1871 [PubMed]

2018

Rouwet Ellen, Lutgens Esther 2016 Jeffrey M. Hoeg Award Lecture Arteriosclerosis, thrombosis, and vascular biology 2018;38 (8):1678-1688 [PubMed]
Baardman Jeroen, Verberk Sanne G. S., Prange Koen H. M., van Weeghel Michel, van der Velden Saskia, Ryan Dylan G., Wüst Rob C. I., Neele Annette E., Speijer Dave, Denis Simone W., Witte Maarten E., Houtkooper Riekelt H., O'neill Luke A., Knatko Elena V., Dinkova-Kostova Albena T., Lutgens Esther, de Winther Menno P. J., van den Bossche Jan A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia Cell reports 2018;25 (8):2044-2052 [PubMed]
Seijkens Tom T. P., Lutgens Esther Cardiovascular oncology: exploring the effects of targeted cancer therapies on atherosclerosis Current opinion in lipidology 2018;29 (5):381-388 [PubMed]
Aarts Suzanne A. B. M. CD40 in MS: Multiple sclerosis and the metabolic syndrome 2018. 203p. ISBN 9789463750523. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Lutgens E., de Winther M. P. J.; Co-supervisors: Kooij G., Seijkens T. T. P.)
Steven Sebastian, Dib Mobin, Hausding Michael, Kashani Fatemeh, Oelze Matthias, Kröller-Schön Swenja, Hanf Alina, Daub Steffen, Roohani Siyer, Gramlich Yves, Lutgens Esther, Schulz Eberhard, Becker Christian, Lackner Karl J., Kleinert Hartmut, Knosalla Christoph, Niesler Beate, Wild Philipp S., Münzel Thomas, Daiber Andreas CD40L controls obesity-associated vascular inflammation, oxidative stress, and endothelial dysfunction in high fat diet-treated and db/db mice Cardiovascular research 2018;114 (2):312-323 [PubMed]
Kusters Pascal J. H., Seijkens Tom T. P., Beckers Linda, Lievens Dirk, Winkels Holger, de Waard Vivian, Duijvestijn Adriaan, Liljeqvist Moritz Lindquist, Roy Joy, Daugherty Alan, Newby Andrew, Gerdes Norbert, Lutgens Esther CD40L deficiency protects against aneurysm formation Arteriosclerosis, thrombosis, and vascular biology 2018;38 (5):1076-1085 [PubMed]
Eikendal Anouk L. M., Bots Michiel L., Gohar Aisha, Lutgens Esther, Hoefer Imo E., den Ruijter Hester M., Leiner Tim Circulating levels of P-selectin and E-selectin relate to cardiovascular magnetic resonance-derived aortic characteristics in young adults from the general population, a cross-sectional study Journal of cardiovascular magnetic resonance 2018;20 (1) [PubMed]
den Harder Annemarie M., de Jong Pim A., de Groot Mark C. H., Wolterink Jelmer M., Budde Ricardo P. J., Iŝgum Ivana, van Solinge Wouter W., ten Berg Maarten J., Lutgens Esther, Veldhuis Wouter B., Haitjema Saskia, Hoefer Imo E., Leiner Tim Commonly available hematological biomarkers are associated with the extent of coronary calcifications Atherosclerosis 2018;275:166-173 [PubMed]
Lameijer Marnix, Binderup Tina, van Leent Mandy M. T., Senders Max L., Fay Francois, Malkus Joost, Sanchez-Gaytan Brenda L., Teunissen Abraham J. P., Karakatsanis Nicolas, Robson Philip, Zhou Xianxiao, Ye Yuxiang, Wojtkiewicz Gregory, Tang Jun, Seijkens Tom T. P., Kroon Jeffrey, Stroes Erik S. G., Kjaer Andreas, Ochando Jordi, Reiner Thomas, Pérez-Medina Carlos, Calcagno Claudia, Fischer Edward A., Zhang Bin, Temel Ryan E., Swirski Filip K., Nahrendorf Matthias, Fayad Zahi A., Lutgens Esther, Mulder Willem J. M., Duivenvoorden Raphaël Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates Nature Biomedical Engineering 2018;2 (5):279-292 [PubMed]
Lameijer Marnix, Binderup Tina, van Leent Mandy M. T., Senders Max L., Fay Francois, Malkus Joost, Sanchez-Gaytan Brenda L., Teunissen Abraham J. P., Karakatsanis Nicolas, Robson Philip, Zhou Xianxiao, Ye Yuxiang, Wojtkiewicz Gregory, Tang Jun, Seijkens Tom T. P., Kroon Jeffrey, Stroes Erik S. G., Kjaer Andreas, Ochando Jordi, Reiner Thomas, Pérez-Medina Carlos, Calcagno Claudia, Fisher Edward A., Zhang Bin, Temel Ryan E., Swirski Filip K., Nahrendorf Matthias, Fayad Zahi A., Lutgens Esther, Mulder Willem J. M., Duivenvoorden Raphaël Erratum to: Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates (Nature Biomedical Engineering, (2018), 2, 5, (279-292), 10.1038/s41551-018-0221-2) Nature Biomedical Engineering 2018;2 (8):623 [PubMed]
Kusters Pascal J. H., Lutgens Esther, Seijkens Tom T. P. Exploring immune checkpoints as potential therapeutic targets in atherosclerosis Cardiovascular research 2018;114 (3):368-377 [PubMed]
Caporali Andrea, Bäck Magnus, Daemen Mat J., Hoefer Imo E., Jones Elizabeth A., Lutgens Esther, Matter Christian M., Bochaton-Piallat Marie-Luce, Siekmann Arndt F., Sluimer Judith C., Steffens Sabine, Tuñón José, Vindis Cecile, Wentzel Jolanda J., Ylä-Herttuala Seppo, Evans Paul C. Future directions for therapeutic strategies in post-ischaemic vascularization: A position paper from European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology Cardiovascular research 2018;114 (11):1411-1421 [PubMed]
Braza Mounia S., van Leent Mandy M. T., Lameijer Marnix, Sanchez-Gaytan Brenda L., Arts Rob J. W., Pérez-Medina Carlos, Conde Patricia, Garcia Mercedes R., Gonzalez-Perez Maria, Brahmachary Manisha, Fay Francois, Kluza Ewelina, Kossatz Susanne, Dress Regine J., Salem Fadi, Rialdi Alexander, Reiner Thomas, Boros Peter, Strijkers Gustav J., Calcagno Claudia C., Ginhoux Florent, Marazzi Ivan, Lutgens Esther, Nicolaes Gerry A. F., Weber Christian, Swirski Filip K., Nahrendorf Matthias, Fisher Edward A., Duivenvoorden Raphaël, Fayad Zahi A., Netea Mihai G., Mulder Willem J. M., Ochando Jordi Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance Immunity 2018;49 (5):819-828.e6 [PubMed]
Tuñón José, Bäck Magnus, Badimón Lina, Bochaton-Piallat Marie-Luce, Cariou Bertrand, Daemen Mat J., Egido Jesus, Evans Paul C., Francis Sheila E., Ketelhuth Daniel F. J., Lutgens Esther, Matter Christian M., Monaco Claudia, Steffens Sabine, Stroes Erik, Vindis C. cile, Weber Christian, Hoefer Imo E. Interplay between hypercholesterolaemia and inflammation in atherosclerosis: Translating experimental targets into clinical practice European journal of preventive cardiology 2018;25 (9):948-955 [PubMed]
Aarts Suzanne A. B. M., Reiche Myrthe E., den Toom Myrthe, Beckers Linda, Gijbels Marion J. J., Gerdes Norbert, de Winther Menno P. J., Lutgens Esther Macrophage CD40 plays a minor role in obesity-induced metabolic dysfunction PLoS ONE 2018;13 (8) [PubMed]
Neele Annette E. Macrophage regulatory mechanisms in atherosclerosis: The interplay of lipids and inflammation 2018. 241p. ISBN 9789402808773. [UvA Dissertations Online] University of Amsterdam. (Supervisors: de Winther M. P. J., Lutgens E.; Co-supervisors: Gijbels M. J. J., van den Bossche J.)
Hoogeveen Renate M., Nahrendorf Matthias, Riksen Niels P., Netea Mihai G., de Winther Menno P. J., Lutgens Esther, Nordestgaard B. rge G., Neidhart Michel, Stroes Erik S. G., Catapano Alberico L., Bekkering Siroon Monocyte and haematopoietic progenitor reprogramming as common mechanism underlying chronic inflammatory and cardiovascular diseases European heart journal 2018;39 (38):3521-3527 [PubMed]
Neele Annette E., Gijbels Marion J. J., van der Velden Saskia, Hoeksema Marten A., Boshuizen Marieke C. S., Prange Koen H. M., Chen Hung-Jen, van den Bossche Jan, van Roomen Cindy P. P. A., Shami Annelie, Levels Johannes H. M., Kroon Jeffrey, Lucas Tina, Dimmeler Stefanie, Lutgens Esther, de Winther Menno P. J. Myeloid Kdm6b deficiency results in advanced atherosclerosis Atherosclerosis 2018;275:156-165 [PubMed]
Patel Jyoti, Lutgens Esther Scientists on the Spot: Esther Lutgens on the immune system and atherosclerosis Cardiovascular research 2018;114 (14):e113 [PubMed]
Seijkens Tom T. P., van Tiel Claudia M., Kusters Pascal J. H., Atzler Dorothee, Soehnlein Oliver, Zarzycka Barbara, Aarts Suzanne A. B. M., Lameijer Marnix, Gijbels Marion J., Beckers Linda, den Toom Myrthe, Slütter Bram, Kuiper Johan, Duchene Johan, Aslani Maria, Megens Remco T. A., van 't Veer Cornelis, Kooij Gijs, Schrijver Roy, Hoeksema Marten A., Boon Louis, Fay Francois, Tang Jun, Baxter Samantha, Jongejan Aldo, Moerland Perry D., Vriend Gert, Bleijlevens Boris, Fisher Edward A., Duivenvoorden Raphael, Gerdes Norbert, de Winther Menno P. J., Nicolaes Gerry A., Mulder Willem J. M., Weber Christian, Lutgens Esther Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis Journal of the American College of Cardiology 2018;71 (5):527-542 [PubMed]
Lameijer Marnix Targeting macrophage dynamics to regulate the cardiovascular immune response 2018. ISBN 9789402808964. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Mulder W. J. M, Lutgens E.; Co-supervisors: Duivenvoorden R., Kluza E.)

2017

van den Berg Susanna M. A hot interaction between immune cells and adipose tissue 2017. 150p. ISBN 9789462995918. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Lutgens E. , de Winther M. P. J. , Rensen P. C. N.)
Jung Christian, Lichtenauer Michael, Strodthoff Daniela, Winkels Holger, Wernly Bernhard, Bürger Christina, Kamchybekov Uran, Lutgens Esther, Figulla Hans-Reiner, Gerdes Norbert Alterations in systemic levels of Th1, Th2, and Th17 cytokines in overweight adolescents and obese mice Pediatric diabetes 2017;18 (8):714-721 [PubMed]
Ferrari Elena, Lutgens Esther, Weber Christian, Gerdes Norbert Atherosclerosis: cell biology and lipoproteins focus on epigenetic modification and macrophage biology Current opinion in lipidology 2017;28 (2):220-221 [PubMed]
Winkels Holger, Meiler Svenja, Lievens Dirk, Engel David, Spitz Charlotte, Bürger Christina, Beckers Linda, Dandl Angelika, Reim Sigrid, Ahmadsei Maiwand, Hartwig Helene, Holdt Lesca M., Hristov Michael, Megens Remco T. A., Schmitt Martin M., Biessen Eric A., Borst Jannie, Faussner Alexander, Weber Christian, Lutgens Esther, Gerdes Norbert CD27 co-stimulation increases the abundance of regulatory T cells and reduces atherosclerosis in hyperlipidaemic mice European heart journal 2017;38 (48):3590-3599 [PubMed]
Barthels Christian, Ogrinc Ana, Steyer Verena, Meier Stefanie, Simon Ferdinand, Wimmer Maria, Blutke Andreas, Straub Tobias, Zimber-Strobl Ursula, Lutgens Esther, Marconi Peggy, Ohnmacht Caspar, Garzetti Debora, Stecher Bärbel, Brocker Thomas CD40-signalling abrogates induction of ROR gamma t(+) Treg cells by intestinal CD103(+) DCs and causes fatal colitis Nature communications 2017;8 [PubMed]
Winkels Holger, Meiler Svenja, Smeets Esther, Lievens Dirk, Engel David, Spitz Charlotte, Bürger Christina, Rinne Petteri, Beckers Linda, Dandl Angelika, Reim Sigrid, Ahmadsei Maiwand, van den Bossche Jan, Holdt Lesca M., Megens Remco T. A., Schmitt Martin, de Winther Menno P.J., Biessen Eric A., Borst Jannie, Faussner Alexander, Weber Christian, Lutgens Esther, Gerdes Norbert CD70 limits atherosclerosis and promotes macrophage function Thrombosis and haemostasis 2017;117 (1):164-175 [PubMed]
von Hundelshausen Philipp, Agten Stijn M., Eckardt Veit, Blanchet Xavier, Schmitt Martin M., Ippel Hans, Neideck Carlos, Bidzhekov Kiril, Leberzammer Julian, Wichapong Kanin, Faussner Alexander, Drechsler Maik, Grommes Jochen, van Geffen Johanna P., Li He, Ortega-Gomez Almudena, Megens Remco T. A., Naumann Ronald, Dijkgraaf Ingrid, Nicolaes Gerry A. F., Döring Yvonne, Soehnlein Oliver, Lutgens Esther, Heemskerk Johan W. M., Koenen Rory R., Mayo Kevin H., Hackeng Tilman M., Weber Christian Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation Science translational medicine 2017;9 (384):eaah6650 [PubMed]
Kusters Pascal, Seijkens Tom, Bürger Christina, Legein Bart, Winkels Holger, Gijbels Marion, Barthels Christian, Bennett Remy, Beckers Linda, Atzler Dorothee, Biessen Erik, Brocker Thomas, Weber Christian, Gerdes Norbert, Lutgens Esther Constitutive CD40 Signaling in Dendritic Cells Limits Atherosclerosis by Provoking Inflammatory Bowel Disease and Ensuing Cholesterol Malabsorption American journal of pathology 2017;187 (12):2912-2919 [PubMed]
van den Berg Susan M., van Dam Andrea D., Kusters Pascal J. H., Beckers Linda, den Toom Myrthe, van der Velden Saskia, van den Bossche Jan, van Die Irma, Boon Mariëtte R., Rensen Patrick C. N., Lutgens Esther, de Winther Menno P. J. Helminth antigens counteract a rapid high-fat diet-induced decrease in adipose tissue eosinophils Journal of molecular endocrinology 2017;59 (3):245-255 [PubMed]
Beldman Thijs J., Senders Max L., Alaarg Amr, Pérez-Medina Carlos, Tang Jun, Zhao Yiming, Fay Francois, Deichmöller Jacqueline, Born Benjamin, Desclos Emilie, van der Wel Nicole N., Hoebe Ron A., Kohen Fortune, Kartvelishvily Elena, Neeman Michal, Reiner Thomas, Calcagno Claudia, Fayad Zahi A., de Winther Menno P. J., Lutgens Esther, Mulder Willem J. M., Kluza Ewelina Hyaluronan Nanoparticles Selectively Target Plaque-Associated Macrophages and Improve Plaque Stability in Atherosclerosis ACS nano 2017;11 (6):5785-5799 [PubMed]
van den Berg Susan M., van Dam Andrea D., Rensen Patrick C. N., de Winther Menno P. J., Lutgens Esther Immune Modulation of Brown(ing) Adipose Tissue in Obesity Endocrine reviews 2017;38 (1):46-68 [PubMed]
Wolf Dennis, Bukosza Nora, Engel David, Poggi Marjorie, Jehle Felix, Anto Michel Nathaly, Chen Yung-Chih, Colberg Christian, Hoppe Natalie, Dufner Bianca, Boon Louis, Blankenbach Hermann, Hilgendorf Ingo, von Zur Muhlen Constantin, Reinöhl Jochen, Sommer Björn, Marchini Timoteo, Febbraio Mark A., Weber Christian, Bode Christoph, Peter Karlheinz, Lutgens Esther, Zirlik Andreas Inflammation, but not recruitment, of adipose tissue macrophages requires signalling through Mac-1 (CD11b/CD18) in diet-induced obesity (DIO) Thrombosis and haemostasis 2017;117 (2):325-338 [PubMed]
Aarts Suzanne A. B. M., Seijkens Tom T. P., Kusters Pascal J. H., van der Pol Susanne M. A., Zarzycka Barbara, Heijnen Priscilla D. A. M., Beckers Linda, den Toom Myrthe, Gijbels Marion J. J., Boon Louis, Weber Christian, de Vries Helga E., Nicolaes Gerry A. F., Dijkstra Christine D., Kooij Gijs, Lutgens Esther Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation Journal of neuroinflammation 2017;14 (1) [PubMed]
Neele Annette E., Prange Koen Hm, Hoeksema Marten A., van der Velden Saskia, Lucas Tina, Dimmeler Stefanie, Lutgens Esther, van den Bossche Jan, de Winther Menno P. J. Macrophage Kdm6b controls the pro-fibrotic transcriptome signature of foam cells Epigenomics 2017;9 (4):383-391 [PubMed]
Ridger Victoria C., Boulanger Chantal M., Angelillo-Scherrer Anne, Badimon Lina, Blanc-Brude Olivier, Bochaton-Piallat Marie-Luce, Boilard Eric, Buzas Edit I., Caporali Andreas, Dignat-George Françoise, Evans Paul C., Lacroix Romaric, Lutgens Esther, Ketelhuth Daniel F. J., Nieuwland Rienk, Toti Florence, Tunon Jose, Weber Christian, Hoefer Imo E. Microvesicles in vascular homeostasis and diseases Position Paper of the European Society of Cardiology (ESC) Working Group on Atherosclerosis and Vascular Biology Thrombosis and haemostasis 2017;117 (7):1296-1316 [PubMed]
Hakimzadeh Nazanin, Pinas Victorine A., Molenaar Ger, de Waard Vivian, Lutgens Esther, van Eck-Smit Berthe L. F., de Bruin Kora, Piek Jan J., Eersels Jos L. H., Booij Jan, Verberne Hein J., Windhorst Albert D. Novel molecular imaging ligands targeting matrix metalloproteinases 2 and 9 for imaging of unstable atherosclerotic plaques PLoS ONE 2017;12 (11) [PubMed]
Aarts Suzanne A. B. M., Seijkens Tom T. P., van Dorst Koos J. F., Dijkstra Christine D., Kooij Gijs, Lutgens Esther The CD40-CD40L Dyad in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis Frontiers in immunology 2017;8 [PubMed]
Winkels Holger The role of the co-stimulatory CD27-CD70 dyad in atherosclerosis 2017. [UvA Dissertations Online] Ludwig Maximilians University (LMU), Munchen: -. (Supervisor: Lutgens E.; Co-supervisor: Gerdes M.)
Garg Garima, Nikolouli Eirini, Hardtke-Wolenski Matthias, Toker Aras, Ohkura Naganari, Beckstette Michael, Miyao Takahisa, Geffers Robert, Floess Stefan, Gerdes Norbert, Lutgens Esther, Osterloh Anke, Hori Shohei, Sakaguchi Shimon, Jaeckel Elmar, Huehn Jochen Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells Oncotarget 2017;8 (22):35542-35557 [PubMed]
Döring Yvonne, Noels Heidi, van der Vorst Emiel P. C., Neideck Carlos, Egea Virginia, Drechsler Maik, Mandl Manuela, Pawig Lukas, Jansen Yvonne, Schröder Katrin, Bidzhekov Kiril, Megens Remco T. A., Theelen Wendy, Klinkhammer Barbara M., Boor Peter, Schurgers Leon, van Gorp Rick, Ries Christian, Kusters Pascal J. H., van der Wal Allard, Hackeng Tilman M., Gäbel Gabor, Brandes Ralf P., Soehnlein Oliver, Lutgens Esther, Vestweber Dietmar, Teupser Daniel, Holdt Lesca M., Rader Daniel J., Saleheen Danish, Weber Christian Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity: Evidence From Mouse and Human Studies Circulation 2017;136 (4):388-403 [PubMed]

2016

Meiler Svenja, Lutgens Esther, Weber Christian, Gerdes Norbert Atherosclerosis: cell biology and lipoproteins-focus on interleukin-18 signaling, chemotactic heteromers, and microRNAs Current opinion in lipidology 2016;27 (3):308-309 [PubMed]
Schaftenaar Frank, Frodermann Vanessa, Kuiper Johan, Lutgens Esther Atherosclerosis: the interplay between lipids and immune cells Current opinion in lipidology 2016;27 (3):209-215 [PubMed]
van Dam Andrea D., Bekkering Siroon, Crasborn Malou, van Beek Lianne, van den Berg Susan M., Vrieling Frank, Joosten Simone A., van Harmelen Vanessa, de Winther Menno P. J., Lütjohann Dieter, Lutgens Esther, Boon Mariëtte R., Riksen Niels P., Rensen Patrick C. N., Berbée Jimmy F. P. BCG lowers plasma cholesterol levels and delays atherosclerotic lesion progression in mice Atherosclerosis 2016;251:6-14 [PubMed]
Braster Quinte, Silvestre-Roig Carlos, Hartwig Helene, Kusters Pascal, Aarts Suzanne, den Toom Myrthe, Gallo Richard L., Weber Christian, Lutgens Esther, Soehnlein Oliver Cathelicidin regulates myeloid cell accumulation in adipose tissue and promotes insulin resistance during obesity Thrombosis and haemostasis 2016;115 (6):1237-1239 [PubMed]
Jansen Matthijs F., Hollander Maurits R., van Royen Niels, Horrevoets Anton J., Lutgens Esther CD40 in coronary artery disease: a matter of macrophages? Basic research in cardiology 2016;111 (4):38 [PubMed]
Meiler Svenja, Smeets Esther, Winkels Holger, Shami Annelie, Pascutti Maria Fernanda, Nolte Martijn A., Beckers Linda, Weber Christian, Gerdes Norbert, Lutgens Esther Constitutive GITR Activation Reduces Atherosclerosis by Promoting Regulatory CD4+ T-Cell Responses-Brief Report Arteriosclerosis, thrombosis, and vascular biology 2016;36 (9):1748-1752 [PubMed]
Boshuizen Marieke C. S. Cytokines in atherosclerosis: an intricate balance 2016. 179p. ISBN 9789462992931. [UvA Dissertations Online] University of Amsterdam. (Supervisors: de Winther M. P. J., Lutgens E.; Co-supervisor: Gijbels M. J. J.)
van den Berg Susan M., Seijkens Tom T. P., Kusters Pascal J. H., Beckers Linda, den Toom Myrthe, Smeets Esther, Levels Johannes, de Winther Menno P. J., Lutgens Esther Diet-induced obesity in mice diminishes hematopoietic stem and progenitor cells in the bone marrow FASEB journal 2016;30 (5):1779-1788 [PubMed]
Hoeksema Marten A. Epigenetic regulation of macrophage function 2016. 307p. ISBN 9789461699336. [UvA Dissertations Online] University of Amsterdam. (Supervisors: de Winther M. P. J., Lutgens E.)
Derks W. Inflammation as orchestrator of cardiac disease progression 2016. 167p. [UvA Dissertations Online] Maastricht University: CARIM. (Supervisors: Heymans S., Lutgens E.; Co-supervisor: van Bilsen M.)
Braster Quinte, Silvestre Roig Carlos, Hartwig Helene, Beckers Linda, den Toom Myrthe, Döring Yvonne, Daemen Mat J., Lutgens Esther, Soehnlein Oliver Inhibition of NET Release Fails to Reduce Adipose Tissue Inflammation in Mice PLoS ONE 2016;11 (10):e0163922 [PubMed]
Boshuizen Marieke C. S., Hoeksema Marten A., Neele Annette E., van der Velden Saskia, Hamers Anouk A. J., van den Bossche Jan, Lutgens Esther, de Winther Menno P. J. Interferon-β promotes macrophage foam cell formation by altering both cholesterol influx and efflux mechanisms Cytokine 2016;77:220-226 [PubMed]
van der Valk Fleur M., Schulte Dominik M., Meiler Svenja, Tang Jun, Zheng Kang He, van den Bossche Jan, Seijkens Tom, Laudes Matthias, de Winther Menno, Lutgens Esther, Alaarg Amr, Metselaar Josbert M., Dallinga-Thie Geesje M., Mulder Willem J. M., Stroes Erik S. G., Hamers Anouk A. J. Liposomal prednisolone promotes macrophage lipotoxicity in experimental atherosclerosis Nanomedicine: nanotechnology, biology and medicine 2016;12 (6):1463-1470 [PubMed]
Hartwig Helene Neutrophils: emerging role in the immunopathology of atherosclerosis 2016. 213p. ISBN 9789462954274. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Daemen M. J. A. P., Lutgens E.; Co-supervisor: Soehnlein O.)
Gerdes Norbert, Seijkens Tom, Lievens Dirk, Kuijpers Marijke J. E., Winkels Holger, Projahn Delia, Hartwig Helene, Beckers Linda, Megens Remco T. A., Boon Louis, Noelle Randolph J., Soehnlein Oliver, Heemskerk Johan W. M., Weber Christian, Lutgens Esther Platelet CD40 Exacerbates Atherosclerosis by Transcellular Activation of Endothelial Cells and Leukocytes Arteriosclerosis, thrombosis, and vascular biology 2016;36 (3):482-490 [PubMed]
Spitz Charlotte, Winkels Holger, Bürger Christina, Weber Christian, Lutgens Esther, Hansson Göran K., Gerdes Norbert Regulatory T cells in atherosclerosis: critical immune regulatory function and therapeutic potential Cellular and molecular life sciences 2016;73 (5):901-922 [PubMed]
Hibender Stijntje, Franken Romy, van Roomen Cindy, ter Braake Anique, van der Made Ingeborg, Schermer Edith E., Gunst Quinn, van den Hoff Maurice J., Lutgens Esther, Pinto Yigal M., Groenink Maarten, Zwinderman Aeilko H., Mulder Barbara J. M., de Vries Carlie J. M., de Waard Vivian Resveratrol Inhibits Aortic Root Dilatation in the Fbn1C1039G/+ Marfan Mouse Model Arteriosclerosis, thrombosis, and vascular biology 2016;36 (8):1618-1626 [PubMed]
Legein Bart Role of dendritic cell subsets in hyperlipidemia and atherosclerosis 2016. [UvA Dissertations Online] Maastricht University: CARIM. (Supervisors: Biessen E., Lutgens E.; Co-supervisor: Temmerman L.)

2015

Legein Bart, Janssen Edith M., Theelen Thomas L., Gijbels Marion J., Walraven Joep, Klarquist Jared S., Hennies Cassandra M., Wouters Kristiaan, Seijkens Tom T. P., Wijnands Erwin, Sluimer Judith C., Lutgens Esther, Zenke Martin, Hildner Kai, Biessen Erik A. L., Temmerman Lieve Ablation of CD8α(+) dendritic cell mediated cross-presentation does not impact atherosclerosis in hyperlipidemic mice Scientific reports 2015;5:15414 [PubMed]
Zirlik A., Lutgens E. An inflammatory link in atherosclerosis and obesity. Co-stimulatory molecules Hamostaseologie 2015;35 (3):272-278 [PubMed]
Bürger Christina, Weber Christian, Lutgens Esther, Gerdes Norbert Atherosclerosis: cell biology and lipoproteins-focus on CD40 signaling, PCSK9, and novel animal models Current opinion in lipidology 2015;26 (3):245-246 [PubMed]
Hartwig Helene, Silvestre-Roig Carlos, Hendrikse Jeffrey, Beckers Linda, Paulin Nicole, van der Heiden Kim, Braster Quinte, Drechsler Maik, Daemen Mat J., Lutgens Esther, Soehnlein Oliver Atherosclerotic Plaque Destabilization in Mice: A Comparative Study PLoS ONE 2015;10 (10):e0141019 [PubMed]
van den Berg S. M., Seijkens T. T. P., Kusters P. J. H., Zarzycka B., Beckers L., den Toom M., Gijbels M. J. J., Chatzigeorgiou A., Weber C., de Winther M. P. J., Chavakis T., Nicolaes G. A. F., Lutgens E. Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice International journal of obesity (2005) 2015;39 (5):782-790 [PubMed]
Kusters Pascal J. H., Lutgens Esther Cytokines and Immune Responses in Murine Atherosclerosis Methods in molecular biology (Clifton, N.J.) 2015;1339:17-40 [PubMed]
Zarzycka Barbara, Seijkens Tom, Nabuurs Sander B., Ritschel Tina, Grommes Jochen, Soehnlein Oliver, Schrijver Roy, van Tiel Claudia M., Hackeng Tilman M., Weber Christian, Giehler Fabian, Kieser Arnd, Lutgens Esther, Vriend Gert, Nicolaes Gerry A. F. Discovery of Small Molecule CD40-TRAF6 Inhibitors Journal of chemical information and modeling 2015;55 (2):294-307 [PubMed]
Hartwig H., Silvestre Roig C., Daemen M., Lutgens E., Soehnlein O. Neutrophils in atherosclerosis. A brief overview Hamostaseologie 2015;35 (2):121-127 [PubMed]
Kuijpers Marijke J. E., Mattheij Nadine J. A., Cipolla Lina, van Geffen Johanna P., Lawrence Toby, Donners Marjo M. P. C., Boon Louis, Lievens Dirk, Torti Mauro, Noels Heidi, Gerdes Norbert, Cosemans Judith M. E. M., Lutgens Esther, Heemskerk Johan W. M. Platelet CD40L Modulates Thrombus Growth Via Phosphatidylinositol 3-Kinase β, and Not Via CD40 and IκB Kinase α Arteriosclerosis, thrombosis, and vascular biology 2015;35 (6):1374-1381 [PubMed]
Bäck M., Weber C., Lutgens E. Regulation of atherosclerotic plaque inflammation Journal of internal medicine 2015;278 (5):462-482 [PubMed]
van Dam Andrea D., Nahon Kimberly J., Kooijman Sander, van den Berg Susan M., Kanhai Anish A., Kikuchi Takuya, Heemskerk Mattijs M., van Harmelen Vanessa, Lombès Marc, van den Hoek Anita M., de Winther Menno P. J., Lutgens Esther, Guigas Bruno, Rensen Patrick C. N., Boon Mariëtte R. Salsalate activates brown adipose tissue in mice Diabetes 2015;64 (5):1544-1554 [PubMed]
Zarzycka Barbara, Nicolaes Gerry A. F., Lutgens Esther Targeting the adaptive immune system: new strategies in the treatment of atherosclerosis Expert review of clinical pharmacology 2015;8 (3):297-313 [PubMed]
Yamano Tomoyoshi, Nedjic Jelena, Hinterberger Maria, Steinert Madlen, Koser Sandra, Pinto Sheena, Gerdes Norbert, Lutgens Esther, Ishimaru Naozumi, Busslinger Meinrad, Brors Benedikt, Kyewski Bruno, Klein Ludger Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction Immunity 2015;42 (6):1048-1061 [PubMed]

2014

Stöger J. Lauran Atherosclerosis & inflammation: macrophage heterogeneity in focus 2014. 209p. ISBN 9789053358467. [UvA Dissertations Online] University of Amsterdam. (Supervisors: de Winther M. P. J., Lutgens E.; Co-supervisor: Gijbels M. J. J.)
Winkels Holger, Weber Christian, Lutgens Esther, Gerdes Norbert Atherosclerosis: cell biology and lipoproteins focus on iNKT cells and CD40/CD40L in atherosclerosis and metabolic disorders Current opinion in lipidology 2014;25 (5):408-409 [PubMed]
Silvestre-Roig Carlos, de Winther Menno P., Weber Christian, Daemen Mat J., Lutgens Esther, Soehnlein Oliver Atherosclerotic Plaque Destabilization Mechanisms, Models, and Therapeutic Strategies Circulation research 2014;114 (1):214-226 [PubMed]
Chatzigeorgiou Antonios, Seijkens Tom, Zarzycka Barbara, Engel David, Poggi Marjorie, van den Berg Susan, van den Berg Sjoerd, Soehnlein Oliver, Winkels Holger, Beckers Linda, Lievens Dirk, Driessen Ann, Kusters Pascal, Biessen Erik, Garcia-Martin Ruben, Klotzsche-von Ameln Anne, Gijbels Marion, Noelle Randolph, Boon Louis, Hackeng Tilman, Schulte Klaus, Xu Aimin, Vriend Gert, Nabuurs Sander, Chung Kyoung-Jin, Willems van Dijk Ko, Rensen Patrick C. N., Gerdes Norbert, de Winther Menno, Block Norman L., Schally Andrew V., Weber Christian, Bornstein Stefan R., Nicolaes Gerry, Chavakis Triantafyllos, Lutgens Esther Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance Proceedings of the National Academy of Sciences of the United States of America 2014;111 (7):2686-2691 [PubMed]
Lutgens E. CD40-CD40L: a Janus-faced interaction Thrombosis and haemostasis 2014;112 (2):223-223 [PubMed]
Chatzigeorgiou Antonios, Chung Kyoung-Jin, Garcia-Martin Ruben, Alexaki Vasileia-Ismini, Klotzsche-von Ameln Anne, Phieler Julia, Sprott David, Kanczkowski Waldemar, Tzanavari Theodora, Bdeir Mohktar, Bergmann Sibylle, Cartellieri Marc, Bachmann Michael, Nikolakopoulou Polyxeni, Androutsellis-Theotokis Andreas, Siegert Gabriele, Bornstein Stefan R., Muders Michael H., Boon Louis, Karalis Katia P., Lutgens Esther, Chavakis Triantafyllos Dual Role of B7 Costimulation in Obesity-Related Nonalcoholic Steatohepatitis and Metabolic Dysregulation Hepatology (Baltimore, Md.) 2014;60 (4):1196-1210 [PubMed]
Wildhagen Karin C. A. A., Schrijver Roy, Beckers Linda, ten Cate Hugo, Reutelingsperger Chris P. M., Lutgens Esther, Nicolaes Gerry A. F. Effects of exogenous recombinant APC in mouse models of ischemia reperfusion injury and of atherosclerosis PLoS ONE 2014;9 (7):e101446-(10 p.) [PubMed]
Chatzigeorgiou Antonios, Seijkens Tom, Zarzycka Barbara, Engel David, Poggi Marjorie, van den Berg Susan, van den Berg Sjoerd, Soehnlein Oliver, Winkels Holger, Beckers Linda, Lievens Dirk, Driessen Ann, Kusters Pascal, Biessen Erik, Garcia-Martin Ruben, Ameln Anne Klotzsche-Von, Gijbels Marion, Noelle Randolph, Boon Louis, Hackeng Tilman, Schulte Klaus-Martin, Xu Aimin, Vriend Gert, Nabuurs Sander, Chung Kyoung-Jin, van Dijk Ko Willems, Rensen Patrick C. N., Gerdes Norbert, de Winther Menno, Block Norman L., Schally Andrew V., Weber Christian, Bornstein Stefan R., Nicolaes Gerry, Chavakis Triantafyllos, Lutgens Esther Erratum: Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance (Proceedings of the National Academy of Sciences of the United States of America (2014) 111, 7 (2686-2691) DOI: 10.1073/pnas.1400419111) Proceedings of the National Academy of Sciences of the United States of America 2014;111 (12):4644
Seijkens T. T. P. From hematopoietic stem and progenitor cells to mature immune cells in inflammatory diseases 2014. 238p. ISBN 9789088918506. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Lutgens E., de Winther M.)
Vijayan Santosh, Asare Yaw, Grommes Jochen, Soehnlein Oliver, Lutgens Esther, Shagdarsuren Gansuvd, Togtokh Ariunaa, Jacobs Michael, Fischer Jens W., Bernhagen Jürgen, Weber Christian, Schober Andreas, Shagdarsuren Erdenechimeg High Expression of C5L2 Correlates with High Proinflammatory Cytokine Expression in Advanced Human Atherosclerotic Plaques American journal of pathology 2014;184 (7):2123-2133 [PubMed]
Seijkens Tom, Hoeksema Marten A., Beckers Linda, Smeets Esther, Meiler Svenja, Levels Johannes, Tjwa Marc, de Winther Menno P. J., Lutgens Esther Hypercholesterolemia-induced priming of hematopoietic stem and progenitor cells aggravates atherosclerosis FASEB journal 2014;28 (5):2202-2213 [PubMed]
Seijkens Tom, Kusters Pascal, Chatzigeorgiou Antonios, Chavakis Triantafyllos, Lutgens Esther Immune cell crosstalk in obesity: a key role for costimulation? Diabetes 2014;63 (12):3982-3991 [PubMed]
Mion Francesca, D'Incà Federica, Danelli Luca, Toffoletto Barbara, Guarnotta Carla, Frossi Barbara, Burocchi Alessia, Rigoni Alice, Gerdes Norbert, Lutgens Esther, Tripodo Claudio, Colombo Mario P., Rivera Juan, Vitale Gaetano, Pucillo Carlo E. Mast cells control the expansion and differentiation of IL-10-competent B cells Journal of immunology (Baltimore, Md. 2014;193 (9):4568-4579 [PubMed]
de Winther Menno P. J., Lutgens Esther MiR-92a At the Heart of Lipid-Driven Endothelial Dysfunction Circulation research 2014;114 (3):399-401 [PubMed]
Hartwig H., Drechsler M., Lievens D., Kramp B., von Hundelshausen P., Lutgens E., Weber C., Döring Y., Soehnlein O. Platelet-derived PF4 reduces neutrophil apoptosis following arterial occlusion Thrombosis and haemostasis 2014;111 (3):562-564 [PubMed]
Hoeksema Marten A., Gijbels Marion J. J., van den Bossche Jan, van der Velden Saskia, Sijm Ayestha, Neele Annette E., Seijkens Tom, Stöger J. Lauran, Meiler Svenja, Boshuizen Marieke C. S., Dallinga-Thie Geesje M., Levels Johannes H. M., Boon Louis, Mullican Shannon E., Spann Nathanael J., Cleutjens Jack P., Glass Chris K., Lazar Mitchell A., de Vries Carlie J. M., Biessen Erik A. L., Daemen Mat J. A. P., Lutgens Esther, de Winther Menno P. J. Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions EMBO molecular medicine 2014;6 (9):1124-1132 [PubMed]

2013

Lievens Dirk, Habets Kim L., Robertson Anna-Karin, Laouar Yasmina, Winkels Holger, Rademakers Timo, Beckers Linda, Wijnands Erwin, Boon Louis, Mosaheb Munir, Ait-Oufella Hafid, Mallat Ziad, Flavell Richard A., Rudling Mats, Binder Christoph J., Gerdes Norbert, Biessen Erik A. L., Weber Christian, Daemen Mat J. A. P., Kuiper Johan, Lutgens Esther Abrogated transforming growth factor beta receptor II (TGFβRII) signalling in dendritic cells promotes immune reactivity of T cells resulting in enhanced atherosclerosis European heart journal 2013;34 (48):3717-3727 [PubMed]
Seijkens Tom, Kusters Pascal, Engel David, Lutgens Esther CD40-CD40L: linking pancreatic, adipose tissue and vascular inflammation in type 2 diabetes and its complications Diabetes & vascular disease research 2013;10 (2):115-122 [PubMed]
Soehnlein Oliver, Drechsler Maik, Döring Yvonne, Lievens Dirk, Hartwig Helene, Kemmerich Klaus, Ortega-Gómez Almudena, Mandl Manuela, Vijayan Santosh, Projahn Delia, Garlichs Christoph D., Koenen Rory R., Hristov Mihail, Lutgens Esther, Zernecke Alma, Weber Christian Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes EMBO molecular medicine 2013;5 (3):471-481 [PubMed]
Engel David, Beckers Linda, Wijnands Erwin, Seijkens Tom, Lievens Dirk, Drechsler Maik, Gerdes Norbert, Soehnlein Oliver, Daemen Mat J. A. P., Stan Radu V., Biessen Erik A. L., Lutgens Esther Erratum: Caveolin-1 deficiency decreases atherosclerosis by hampering leukocyte influx into the arterial wall and generating a regulatory T-cell response FASEB journal 2013;27 (8):3408
Legein Bart, Temmerman Lieve, Biessen Erik A. L., Lutgens Esther Inflammation and immune system interactions in atherosclerosis Cellular and molecular life sciences 2013;70 (20):3847-3869 [PubMed]
Smeets Esther, Meiler Svenja, Lutgens Esther Lymphocytic tumor necrosis factor receptor superfamily co-stimulatory molecules in the pathogenesis of atherosclerosis Current opinion in lipidology 2013;24 (6):518-524 [PubMed]
Heymans Stephane, Corsten Maarten F., Verhesen Wouter, Carai Paolo, van Leeuwen Rick E. W., Custers Kevin, Peters Tim, Hazebroek Mark, Stöger Lauran, Wijnands Erwin, Janssen Ben J., Creemers Esther E., Pinto Yigal M., Grimm Dirk, Schürmann Nina, Vigorito Elena, Thum Thomas, Stassen Frank, Yin Xiaoke, Mayr Manuel, de Windt Leon J., Lutgens Esther, Wouters Kristiaan, de Winther Menno P. J., Zacchigna Serena, Giacca Mauro, van Bilsen Marc, Papageorgiou Anna-Pia, Schroen Blanche Macrophage microRNA-155 promotes cardiac hypertrophy and failure Circulation 2013;128 (13):1420-1432 [PubMed]

2012

Döring Yvonne, Manthey Helga D., Drechsler Maik, Lievens Dirk, Megens Remco T. A., Soehnlein Oliver, Busch Martin, Manca Marco, Koenen Rory R., Pelisek Jaroslav, Daemen Mat J., Lutgens Esther, Zenke Martin, Binder Christoph J., Weber Christian, Zernecke Alma Auto-antigenic protein-DNA complexes stimulate plasmacytoid dendritic cells to promote atherosclerosis Circulation 2012;125 (13):1673-1683 [PubMed]
Engel David Caveolin-1 and CD40L-CD40-TRAF interactions in vascular and metabolic disease 2012. 244p. ISBN 9789088914560. [UvA Dissertations Online] Universiteit Maastricht: Pathologie. (Supervisors: Lutgens E., Biessen E. A. L.)
Stöger J. Lauran, Gijbels Marion J. J., van der Velden Saskia, Manca Marco, van der Loos Chris M., Biessen Erik A. L., Daemen Mat J. A. P., Lutgens Esther, de Winther Menno P. J. Distribution of macrophage polarization markers in human atherosclerosis Atherosclerosis 2012;225 (2):461-468 [PubMed]
Lutgens Esther, Leiner Tim, Weber Christian Insight Receptor activation of nuclear factor kB ligand (RANKL) increases the release of neutrophil products associated with coronary vulnerability RANK(L)-ing biomarkers as surrogates for coronary calcium score Thrombosis and haemostasis 2012;107 (1):3-3 [PubMed]
de Waard Vivian, Gijbels Marion J. J., Lutgens Esther, de Winther Menno P. J., de Vries Carlie J. M. Models and Analysis of Atherosclerosis, Restenosis, and Aneurysm Formation in the Mouse Current protocols in mouse biology 2012;2 (4):317-345 [PubMed]
Sanati Maryam The role of cytotoxic T lymphocyte antigen 4 (CTLA-4) in atherosclerosis 2012. 114p. [UvA Dissertations Online] Universiteit Aachen: Fak Naturwissenschaften. (Supervisors: Lutgens E., Bernhagen J.)
Papageorgiou Anna-Pia, Swinnen Melissa, Vanhoutte Davy, VandenDriessche Thierry, Chuah Marinee, Lindner Diane, Verhesen Wouter, de Vries Bart, D'hooge Jan, Lutgens Esther, Westermann Dirk, Carmeliet Peter, Heymans Stephane Thrombospondin-2 prevents cardiac injury and dysfunction in viral myocarditis through the activation of regulatory T-cells Cardiovascular research 2012;94 (1):115-124 [PubMed]

2011

Engel David, Beckers Linda, Wijnands Erwin, Seijkens Tom, Lievens Dirk, Drechsler Maik, Gerdes Norbert, Soehnlein Oliver, Daemen Mat J. A. P., Stan Radu V., Biessen Erik A. L., Lutgens Esther Caveolin-1 deficiency decreases atherosclerosis by hampering leukocyte influx into the arterial wall and generating a regulatory T-cell response FASEB journal 2011;25 (11):3838-3848 [PubMed]
Poggi Marjorie, Engel David, Christ Anette, Beckers Linda, Wijnands Erwin, Boon Louis, Driessen Ann, Cleutjens Jack, Weber Christian, Gerdes Norbert, Lutgens Esther CD40L Deficiency Ameliorates Adipose Tissue Inflammation and Metabolic Manifestations of Obesity in Mice Arteriosclerosis, thrombosis, and vascular biology 2011;31 (10):2251-2260 [PubMed]
Lutgens E., Binder C. J. Immunology of atherosclerosis Thrombosis and haemostasis 2011;106 (5):755-756 [PubMed]
Daissormont Isabelle T. M. N., Christ Anette, Temmerman Lieve, Sampedro Millares Stefan, Seijkens Tom, Rousch Mat, Poggi Marjorie, Boon Louis, van der Loos Chris, Daemen Mat, Lutgens Esther, Halvorsen Bente, Aukrust Pal, Janssen Edith, Biessen Erik A. L. Plasmacytoid Dendritic Cells Protect Against Atherosclerosis by Tuning T-Cell Proliferation and Activity Circulation research 2011;109 (12):1387-1395 [PubMed]
Wildhagen K. C. A. A., Lutgens E., Loubele S. T. G. B., ten Cate H., Nicolaes G. A. F. The structure-function relationship of activated protein C. Lessons from natural and engineered mutations Thrombosis and haemostasis 2011;106 (6):1034-1045 [PubMed]

2010

Bai Lili, Beckers Linda, Wijnands Erwin, Lutgens Suzanne P. M., Herías M. Verónica, Saftig Paul, Daemen Mat J. A. P., Cleutjens Kitty, Lutgens Esther, Biessen Erik A. L., Heeneman Sylvia Cathepsin K gene disruption does not affect murine aneurysm formation Atherosclerosis 2010;209 (1):96-103 [PubMed]
Lutgens Esther, Poggi Marjorie, Weber Christian CD40L-CD40 fuel ignites obesity Thrombosis and haemostasis 2010;103 (4):694-695 [PubMed]
Lievens Dirk Cell-type specific CD40-CD40L interactions in atherosclerosisMaastricht: Die Keure, Bruges, Belgium; 2010. 215p. ISBN 9789090250120. [UvA Dissertations Online] Universiteit Maastricht: Pathologie. (Supervisors: Biessen E. A., Daemen M. J. A. P.; Co-supervisor: Lutgens E.)
Lutgens Esther, Lievens Dirk, Beckers Linda, Wijnands Erwin, Soehnlein Oliver, Zernecke Alma, Seijkens Tom, Engel David, Cleutjens Jack, Keller Anna M., Naik Shalin H., Boon Louis, Oufella Hafid Ait, Mallat Ziad, Ahonen Cory L., Noelle Randolph J., de Winther Menno P., Daemen Mat J., Biessen Erik A., Weber Christian Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile Journal of experimental medicine 2010;207 (2):391-404 [PubMed]
Meuwese Marijn C., Broekhuizen Lysette N., Kuikhoven Mayella, Heeneman Sylvia, Lutgens Esther, Gijbels Marion J. J., Nieuwdorp Max, Peutz Carine J., Stroes Erik S. G., Vink Hans, van den Berg Bernard M. Endothelial surface layer degradation by chronic hyaluronidase infusion induces proteinuria in apolipoprotein e-deficient mice PLoS ONE 2010;5 (12):e14262 [PubMed]
Lobbes M. B. I., Kooi M. E., Lutgens E., Ruiters A. W., Lima Passos V., Braat S. H. J. G., Rousch M., ten Cate H., van Engelshoven J. M. A., Daemen M. J. A. P., Heeneman S. Leukocyte counts, myeloperoxidase, and pregnancy-associated plasma protein a as biomarkers for cardiovascular disease: towards a multi-biomarker approach International journal of vascular medicine 2010;2010:726207 [PubMed]
Loges Sonja, Schmidt Thomas, Tjwa Marc, van Geyte Katie, Lievens Dirk, Lutgens Esther, Vanhoutte Davy, Borgel Delphine, Plaisance Stephane, Hoylaerts Marc, Luttun Aernout, Dewerchin Mieke, Jonckx Bart, Carmeliet Peter Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6 Blood 2010;115 (11):2264-2273 [PubMed]
Goossens Pieter, Gijbels Marion J. J., Zernecke Alma, Eijgelaar Wouter, Vergouwe Monique N., van der Made Ingeborg, Vanderlocht Joris, Beckers Linda, Buurman Wim A., Daemen Mat J. A. P., Kalinke Ulrich, Weber Christian, Lutgens Esther, de Winther Menno P. J. Myeloid type I interferon signaling promotes atherosclerosis by stimulating macrophage recruitment to lesions Cell metabolism 2010;12 (2):142-153 [PubMed]
Lievens Dirk, Zernecke Alma, Seijkens Tom, Soehnlein Oliver, Beckers Linda, Munnix Imke C. A., Wijnands Erwin, Goossens Pieter, van Kruchten Roger, Thevissen Larissa, Boon Louis, Flavell Richard A., Noelle Randolph J., Gerdes Norbert, Biessen Erik A., Daemen Mat J. A. P., Heemskerk Johan W. M., Weber Christian, Lutgens Esther Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis Blood 2010;116 (20):4317-4327 [PubMed]
Hristov Mihail, Gümbel Denis, Lutgens Esther, Zernecke Alma, Weber Christian Soluble CD40 ligand impairs the function of peripheral blood angiogenic outgrowth cells and increases neointimal formation after arterial injury Circulation 2010;121 (2):315-324 [PubMed]
Seijkens Tom, Engel David, Tjwa Marc, Lutgens Esther The role of CD154 in haematopoietic development Thrombosis and haemostasis 2010;104 (4):693-701 [PubMed]

2009

Xanthoulea Sofia, Thelen Melanie, Pöttgens Chantal, Gijbels Marion J. J., Lutgens Esther, de Winther Menno P. J. Absence of p55 TNF receptor reduces atherosclerosis, but has no major effect on angiotensin II induced aneurysms in LDL receptor deficient mice PLoS ONE 2009;4 (7):e6113 [PubMed]
Kuijpers M. J. E., Gilio K., Reitsma S., Nergiz-Unal R., Prinzen L., Heeneman S., Lutgens E., van Zandvoort M. A. M. J., Nieswandt B., Egbrink M. G. A. Oude, Heemskerk J. W. M. Complementary roles of platelets and coagulation in thrombus formation on plaques acutely ruptured by targeted ultrasound treatment: a novel intravital model Journal of thrombosis and haemostasis 2009;7 (1):152-161 [PubMed]
Zernecke Alma, Bidzhekov Kiril, Noels Heidi, Shagdarsuren Erdenechimeg, Gan Lin, Denecke Bernd, Hristov Mihail, Köppel Thomas, Jahantigh Maliheh Nazari, Lutgens Esther, Wang Shusheng, Olson Eric N., Schober Andreas, Weber Christian Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection Science signaling 2009;2 (100):ra81 [PubMed]
Tjwa Marc, Moons Lieve, Lutgens Esther Pleiotropic role of growth arrest-specific gene 6 in atherosclerosis Current opinion in lipidology 2009;20 (5):386-392 [PubMed]
Zouggari Yasmine, Ait-Oufella Hafid, Waeckel Ludovic, Vilar José, Loinard Céline, Cochain Clément, Récalde Alice, Duriez Micheline, Levy Bernard I., Lutgens Esther, Mallat Ziad, Silvestre Jean-Sébastien Regulatory T cells modulate postischemic neovascularization Circulation 2009;120 (14):1415-1425 [PubMed]
Engel David, Seijkens Tom, Poggi Marjorie, Sanati Maryam, Thevissen Larissa, Beckers Linda, Wijnands Erwin, Lievens Dirk, Lutgens Esther The immunobiology of CD154-CD40-TRAF interactions in atherosclerosis Seminars in immunology 2009;21 (5):308-312 [PubMed]
Lievens Dirk, Eijgelaar Wouter J., Biessen Erik A. L., Daemen Mat J. A. P., Lutgens Esther The multi-functionality of CD40L and its receptor CD40 in atherosclerosis Thrombosis and haemostasis 2009;102 (2):206-214 [PubMed]

2008

Smook M. L. F., van Leeuwen M., Heeringa P., Damoiseaux J. G. M. C., Theunissen R., Daemen M. J. A. P., Lutgens E., Tervaert J. W. Cohen Anti-oxLDL antibody isotype levels, as potential markers for progressive atherosclerosis in APOE and APOECD40L mice Clinical and experimental immunology 2008;154 (2):264-269 [PubMed]
Leroyer Aurélie S., Rautou Pierre-Emmanuel, Silvestre Jean-Sébastien, Castier Yves, Lesèche Guy, Devue Cécile, Duriez Micheline, Brandes Ralf P., Lutgens Esther, Tedgui Alain, Boulanger Chantal M. CD40 ligand+ microparticles from human atherosclerotic plaques stimulate endothelial proliferation and angiogenesis a potential mechanism for intraplaque neovascularization Journal of the American College of Cardiology 2008;52 (16):1302-1311 [PubMed]
Heeneman Sylvia, Lutgens Esther, Schapira Kitty B., Daemen Mat J. A. P., Biessen Erik A. L. Control of atherosclerotic plaque vulnerability: insights from transgenic mice Frontiers in bioscience 2008;13:6289-6313 [PubMed]
Tjwa Marc, Bellido-Martin Lola, Lin Yuan, Lutgens Esther, Plaisance Stéphane, Bono Françoise, Delesque-Touchard Nathalie, Hervé Caroline, Moura Rute, Billiau An D., Aparicio Cristina, Levi Marcel, Daemen Mat, Dewerchin Mieke, Lupu Florea, Arnout Jef, Herbert Jean-Marc, Waer Mark, García de Frutos Pablo, Dahlbäck Björn, Carmeliet Peter, Hoylaerts Marc F., Moons Lieve Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes Blood 2008;111 (8):4096-4105 [PubMed]
Lutgens E., Tjwa M., Garcia de Frutos P., Wijnands E., Beckers L., Dahlbäck B., Daemen M. J. A. P., Carmeliet P., Moons L. Genetic loss of Gas6 induces plaque stability in experimental atherosclerosis Journal of pathology 2008;216 (1):55-63 [PubMed]
Donners Marjo M. P. C., Beckers Linda, Lievens Dirk, Munnix Imke, Heemskerk Johan, Janssen Ben J., Wijnands Erwin, Cleutjens Jack, Zernecke Alma, Weber Christian, Ahonen Cory L., Benbow Ulrike, Newby Andrew C., Noelle Randolph J., Daemen Mat J. A. P., Lutgens Esther The CD40-TRAF6 axis is the key regulator of the CD40/CD40L system in neointima formation and arterial remodeling Blood 2008;111 (9):4596-4604 [PubMed]

2007

Smook Marjan Adaptive immunity in atherosclerosis: an in vivio evaluation 2007. 208p. ISBN 9789081171717. [UvA Dissertations Online] Universiteit Maastricht: Immunologie. (Supervisors: Daemen M., Cohen Tervaert J. W.; Co-supervisors: Lutgens E., Heeringa P.)
Lutgens Esther, Lievens Dirk, Beckers Linda, Donners Marjo, Daemen Mat CD40 and its ligand in atherosclerosis Trends in cardiovascular medicine 2007;17 (4):118-123 [PubMed]
Beckers L., Heeneman S., Wang L., Burkly L. C., Rousch M. M. J., Davidson N. O., Gijbels M. J. J., de Winther M. P. J., Daemen M. J. A. P., Lutgens E. Disruption of hedgehog signalling in ApoE - /- mice reduces plasma lipid levels, but increases atherosclerosis due to enhanced lipid uptake by macrophages Journal of pathology 2007;212 (4):420-428 [PubMed]
Lutgens Esther, Leiner Tim, van Suylen Robert-Jan, Daemen Mat J. A. P. The molecular basics of vulnerable plaquein: Handbook of the Vulnerable Plaque, Second Edition. CRC Press; 2007. p. 29-38, ISBN 184184621X

2006

Lutgens E., Lutgens S. P. M., Faber B. C. G., Heeneman S., Gijbels M. M. J., de Winther M. P. J., Frederik P., van der Made I., Daugherty A., Sijbers A. M., Fisher A., Long C. J., Saftig P., Black D., Daemen M. J. A. P., Cleutjens K. B. J. M. Disruption of the cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation Circulation 2006;113 (1):98-107 [PubMed]
Lutgens S. P. M., Kisters N., Lutgens E., van Haaften R. I. M., Evelo C. T. A., de Winther M. P. J., Saftig P., Daemen M. J. A. P., Heeneman S., Cleutjens K. B. J. M. Gene profiling of cathepsin K deficiency in atherogenesis: profibrotic but lipogenic Journal of pathology 2006;210 (3):334-343 [PubMed]
Bijnens A. P. J. J., Lutgens E., Ayoubi T., Kuiper J., Horrevoets A. J., Daemen M. J. A. P. Genome-wide expression studies of atherosclerosis: critical issues in methodology, analysis, interpretation of transcriptomics data Arteriosclerosis, thrombosis, and vascular biology 2006;26 (6):1226-1235 [PubMed]
Lobbes M. B. I., Lutgens E., Heeneman S., Cleutjens K. B. J. M., Kooi M. E., van Engelshoven J. M. A., Daemen M. J. A. P., Nelemans P. J. Is there more than C-reactive protein and fibrinogen? The prognostic value of soluble CD40 ligand, interleukin-6 and oxidized low-density lipoprotein with respect to coronary and cerebral vascular disease Atherosclerosis 2006;187 (1):18-25 [PubMed]
Mulder Willem J. M., Douma Kim, Koning Gerben A., van Zandvoort Marc A., Lutgens Esther, Daemen Mat J., Nicolay Klaas, Strijkers Gustav J. Liposome-enhanced MRI of neointimal lesions in the ApoE-KO mouse Magnetic resonance in medicine 2006;55 (5):1170-1174 [PubMed]

2005

Lutgens Esther, Faber Birgit, Schapira Kitty, Evelo Chris T. A., van Haaften Rachel, Heeneman Sylvia, Cleutjens Kitty B. J. M., Bijnens Ann Pascale, Beckers Linda, Porter J. Gordon, Mackay Charles R., Rennert Paul, Bailly Veronique, Jarpe Matthew, Dolinski Brian, Koteliansky Victor, de Fougerolles Tony, Daemen Mat J. A. P. Gene profiling in atherosclerosis reveals a key role for small inducible cytokines: validation using a novel monocyte chemoattractant protein monoclonal antibody Circulation 2005;111 (25):3443-3452 [PubMed]
Schapira Kitty, Lutgens Esther, de Fougerolles Antonin, Sprague Andrew, Roemen Anouk, Gardner Humphrey, Koteliansky Victor, Daemen Mat, Heeneman Sylvia Genetic deletion or antibody blockade of alpha1beta1 integrin induces a stable plaque phenotype in ApoE-/- mice Arteriosclerosis, thrombosis, and vascular biology 2005;25 (9):1917-1924 [PubMed]
Smook M. L. F., Heeringa P., Damoiseaux J. G. M. C., Daemen M. J. A. P., de Winther M. P. J., Gijbels M. J. J., Beckers L., Lutgens E., Tervaert J. W. Cohen Leukocyte CD40L deficiency affects the CD25(+) CD4 T cell population but does not affect atherosclerosis Atherosclerosis 2005;183 (2):275-282 [PubMed]
Leiner T., Gerretsen S., Botnar R., Lutgens E., Cappendijk V., Kooi E., van Engelshoven J. Magnetic resonance imaging of atherosclerosis European radiology 2005;15 (6):1087-1099 [PubMed]
Curfs Daniëlle M. J., Knaapen Ad M., Pachen Daniëlle M. F. A., Gijbels Marion J. J., Lutgens Esther, Smook Marjan L. F., Kockx Mark M., Daemen Mat J. A. P., van Schooten Frederik J. Polycyclic aromatic hydrocarbons induce an inflammatory atherosclerotic plaque phenotype irrespective of their DNA binding properties FASEB journal 2005;19 (10):1290-1292 [PubMed]

2004

Curfs Daniëlle M. J., Lutgens Esther, Gijbels Marion J. J., Kockx Mark M., Daemen Mat J. A. P., van Schooten Frederik J. Chronic exposure to the carcinogenic compound benzo[a]pyrene induces larger and phenotypically different atherosclerotic plaques in ApoE-knockout mice American journal of pathology 2004;164 (1):101-108 [PubMed]
Tkachenko Eugene, Lutgens Esther, Stan Radu-Virgil, Simons Michael Fibroblast growth factor 2 endocytosis in endothelial cells proceed via syndecan-4-dependent activation of Rac1 and a Cdc42-dependent macropinocytic pathway Journal of cell science 2004;117 (Part 15):3189-3199 [PubMed]
Luttun Aernout, Lutgens Esther, Manderveld Ann, Maris Katleen, Collen Désiré, Carmeliet Peter, Moons Lieve Loss of matrix metalloproteinase-9 or matrix metalloproteinase-12 protects apolipoprotein E-deficient mice against atherosclerotic media destruction but differentially affects plaque growth Circulation 2004;109 (11):1408-1414 [PubMed]

2003

Lutgens Esther, van Suylen Robert-Jan, Faber Birgit C., Gijbels Marion J., Eurlings Petra M., Bijnens Ann-Pascale, Cleutjens Kitty B., Heeneman Sylvia, Daemen Mat J. A. P. Atherosclerotic plaque rupture: local or systemic process? Arteriosclerosis, thrombosis, and vascular biology 2003;23 (12):2123-2130 [PubMed]
Troen Aron M., Lutgens Esther, Smith Donald E., Rosenberg Irwin H., Selhub Jacob The atherogenic effect of excess methionine intake Proceedings of the National Academy of Sciences of the United States of America 2003;100 (25):15089-15094 [PubMed]
Heeneman Sylvia, Cleutjens Jack P., Faber Birgit C., Creemers Esther E., van Suylen Robert-Jan, Lutgens Esther, Cleutjens Kitty B., Daemen Mat J. The dynamic extracellular matrix: intervention strategies during heart failure and atherosclerosis Journal of pathology 2003;200 (4):516-525 [PubMed]

2002

Lutgens Esther, Daemen Mat J. A. P. CD40-CD40L interactions in atherosclerosis Trends in cardiovascular medicine 2002;12 (1):27-32 [PubMed]
Rouwet E. V., Tintu A. N., Schellings M. W. M., van Bilsen M., Lutgens E., Hofstra L., Slaaf D. W., Ramsay G., Le Noble F. A. C. Hypoxia induces aortic hypertrophic growth, left ventricular dysfunction, and sympathetic hyperinnervation of peripheral arteries in the chick embryo Circulation 2002;105 (23):2791-2796 [PubMed]
Lutgens Esther, Gijbels Marion, Smook Marjan, Heeringa Peter, Gotwals Philip, Koteliansky Victor E., Daemen Mat J. A. P. Transforming growth factor-beta mediates balance between inflammation and fibrosis during plaque progression Arteriosclerosis, thrombosis, and vascular biology 2002;22 (6):975-982 [PubMed]

2001

Lutgens E., de Muinck E. D., Heeneman S., Daemen M. J. Compensatory enlargement and stenosis develop in apoE(-/-) and apoE*3-Leiden transgenic mice Arteriosclerosis, thrombosis, and vascular biology 2001;21 (8):1359-1365 [PubMed]
Dhore C. R., Cleutjens J. P., Lutgens E., Cleutjens K. B., Geusens P. P., Kitslaar P. J., Tordoir J. H., Spronk H. M., Vermeer C., Daemen M. J. Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques Arteriosclerosis, thrombosis, and vascular biology 2001;21 (12):1998-2003 [PubMed]
Blankesteijn W. M., Creemers E., Lutgens E., Cleutjens J. P., Daemen M. J., Smits J. F. Dynamics of cardiac wound healing following myocardial infarction: observations in genetically altered mice Acta physiologica Scandinavica 2001;173 (1):75-82 [PubMed]
Lutgens E., Daemen M. J. Transforming growth factor-beta: a local or systemic mediator of plaque stability? Circulation research 2001;89 (10):853-855 [PubMed]

2000

Lutgens E., Cleutjens K. B., Heeneman S., Koteliansky V. E., Burkly L. C., Daemen M. J. Both early and delayed anti-CD40L antibody treatment induces a stable plaque phenotype Proceedings of the National Academy of Sciences of the United States of America 2000;97 (13):7464-7469 [PubMed]
Kliffen M., Lutgens E., Daemen M. J., de Muinck E. D., Mooy C. M., de Jong P. T. The APO(*)E3-Leiden mouse as an animal model for basal laminar deposit British journal of ophthalmology 2000;84 (12):1415-1419 [PubMed]

1999

Lutgens E., Daemen M., Kockx M., Doevendans P., Hofker M., Havekes L., Wellens H., de Muinck E. D. Atherosclerosis in APOE*3-Leiden transgenic mice: from proliferative to atheromatous stage Circulation 1999;99 (2):276-283 [PubMed]
Lutgens E., de Muinck E. D., Kitslaar P. J., Tordoir J. H., Wellens H. J., Daemen M. J. Biphasic pattern of cell turnover characterizes the progression from fatty streaks to ruptured human atherosclerotic plaques Cardiovascular research 1999;41 (2):473-479 [PubMed]
Lutgens E., Daemen M. J., de Muinck E. D., Debets J., Leenders P., Smits J. F. Chronic myocardial infarction in the mouse: cardiac structural and functional changes Cardiovascular research 1999;41 (3):586-593 [PubMed]
Lutgens E., Gorelik L., Daemen M. J., de Muinck E. D., Grewal I. S., Koteliansky V. E., Flavell R. A. Requirement for CD154 in the progression of atherosclerosis Nature medicine 1999;5 (11):1313-1316 [PubMed]
Carmeliet P., Lampugnani M. G., Moons L., Breviario F., Compernolle V., Bono F., Balconi G., Spagnuolo R., Oosthuyse B., Dewerchin M., Zanetti A., Angellilo A., Mattot V., Nuyens D., Lutgens E., Clotman F., de Ruiter M. C., Gittenberger-de Groot A., Poelmann R., Lupu F., Herbert J. M., Collen D., Dejana E. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis Cell 1999;98 (2):147-157 [PubMed]

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