Prof. L. Vermeulen MD PhD publications

2021

• Zhu Zhongxu, Han Guiyuan, Huang Hao, He Lingli, Chen Yu, Ke Jia, Gao Feng, Vermeulen Louis, Wang Xin CHAPTER 1: Genome-wide Discovery of MicroRNA Biomarkers for Cancer Precision Medicinein: Mengsu Yang, Michael Thompson, editors. Detection Methods in Precision Medicine. Royal Society of Chemistry; 2021. p. 1-34
• Ramadan Rana, Vermeulen Louis Confusion on Cell Fusion Cellular and molecular gastroenterology and hepatology 2021;11 (1):304-306 [PubMed]
• Bootsma Sanne, van Neerven Sanne M., Vermeulen Louis Exploiting KRAS-mediated metabolic reprogramming as a therapeutic target Nature genetics 2021;53 (1):9-10 [PubMed]
• Ramadan Rana, Vermeulen Louis Rebuttal to: Digesting the Importance of Cell Fusion in the Intestine Cellular and molecular gastroenterology and hepatology 2021;11 (1):303 [PubMed]

2020

• Narayan Ravi S., Molenaar Piet, Teng Jian, Cornelissen Fleur M. G., Roelofs Irene, Menezes Renee, Dik Rogier, Lagerweij Tonny, Broersma Yoran, Petersen Naomi, Marin Soto Jhon Alexander, Brands Eelke, van Kuiken Philip, Lecca Maria C., Lenos Kristiaan J., in ‘t Veld Sjors G. J. G., van Wieringen Wessel, Lang Frederick F., Sulman Erik, Verhaak Roel, Baumert Brigitta G., Stalpers Lucas J. A., Vermeulen Louis, Watts Colin, Bailey David, Slotman Ben J., Versteeg Rogier, Noske David, Sminia Peter, Tannous Bakhos A., Wurdinger Tom, Koster Jan, Westerman Bart A. A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities Nature communications 2020;11 (1) [PubMed]
• Bastiaenen Vivian P., Klaver Charlotte E. L., van der Heijden Maartje C. S., Nijman Lisanne E., Lecca Maria C., Tanis Pieter J., Lenos Kristiaan J., Vermeulen Louis A mouse model for peritoneal metastases of colorectal origin recapitulates patient heterogeneity Laboratory investigation; a journal of technical methods and pathology 2020;100 (11):1465-1474 [PubMed]
• van der Heijden M. C. S. Colon cancer dynamics in development, progression and growt 2020. 229p. ISBN 9789463239431. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Vermeulen L. , Medema J.; Co-supervisor: Winton D. J.)
• Schwarzmueller Laura, Bril Oscar, Vermeulen Louis, Léveillé Nicolas Emerging role and therapeutic potential of lncrnas in colorectal cancer Cancers 2020;12 (12):1-21 [PubMed]
• Roseweir Antonia K., Park James H., Hoorn Sanne ten, Powell Arfon G. MT, Aherne Susan, Roxburgh Campbell S. D., McMillan Donald C., Horgan Paul G., Ryan Elizabeth, Sheahan Kieran, Vermeulen Louis, Paul James, Harkin Andrea, Graham Janet, Sansom Owen, Church David N., Tomlinson Ian, Saunders Mark, Iveson Tim J., Edwards Joanne Histological phenotypic subtypes predict recurrence risk and response to adjuvant chemotherapy in patients with stage III colorectal cancer journal of pathology. Clinical research 2020;6 (4):283-296 [PubMed]
• Coebergh van den Braak R. R. J., ten Hoorn S., Sieuwerts A. M., Tuynman J. B., Smid M., Wilting S. M., Martens J. W. M., Punt C. J. A., Foekens J. A., Medema J. P., IJzermans J. N. M., Vermeulen L. Interconnectivity between molecular subtypes and tumor stage in colorectal cancer BMC cancer 2020;20 (1):850 [PubMed]
• Adam Ronja S., van Neerven Sanne M., Pleguezuelos-Manzano Cayetano, Simmini Salvatore, Léveillé Nicolas, de Groot Nina E., Holding Andrew N., Markowetz Florian, Vermeulen Louis Intestinal region-specific Wnt signalling profiles reveal interrelation between cell identity and oncogenic pathway activity in cancer development Cancer Cell International 2020;20 (1) [PubMed]
• Dijk Frederike, Veenstra Veronique L., Soer Eline C., Dings Mark P. G., Zhao Lan, Halfwerk Johannes B., Hooijer Gerrit K., Damhofer Helene, Marzano Marco, Steins Anne, Waasdorp Cynthia, Busch Olivier R., Besselink Marc G., Tol Johanna A., Welling Lieke, van Rijssen Lennart B., Klompmaker Sjors, Wilmink Hanneke W., van Laarhoven Hanneke W., Medema Jan Paul, Vermeulen Louis, van Hooff Sander R., Koster Jan, Verheij Joanne, van de Vijver Marc J., Wang Xin, Bijlsma Maarten F. Unsupervised class discovery in pancreatic ductal adenocarcinoma reveals cell-intrinsic mesenchymal features and high concordance between existing classification systems Scientific reports 2020;10 (1):337 [PubMed]

2019

• Lenos Kristiaan J., Lodestijn Sophie C., Lyons Scott K., Bijlsma Maarten F., Miedema Daniël M., Vermeulen Louis A marker-independent lineage-tracing system to quantify clonal dynamics and stem cell functionality in cancer tissue Nature protocols 2019;14 (9):2648-2671 [PubMed]
• Lodestijn Sophie C., Lenos Kristiaan J., Miedema Daniël M., Bijlsma Maarten F., Vermeulen Louis Cancer stem cells: here, there, and everywhere Molecular & cellular oncology 2019;6 (1):e1540235.1-e1540235.3 [PubMed]
• Zhao Linjie, Wang Wei, Xu Lian, Yi Tao, Zhao Xia, Wei Yuquan, Vermeulen Louis, Goel Ajay, Zhou Shengtao, Wang Xin Correction: Integrative network biology analysis identifies miR-508-3p as the determinant for the mesenchymal identity and a strong prognostic biomarker of ovarian cancer (Oncogene, (2019), 38, 13, (2305-2319), 10.1038/s41388-018-0577-5) Oncogene 2019;38:7279-7280 [PubMed]
• Gao Feng, Wang Wei, Tan Miaomiao, Zhu Lina, Zhang Yuchen, Fessler Evelyn, Vermeulen Louis, Wang Xin DeepCC: a novel deep learning-based framework for cancer molecular subtype classification Oncogenesis 2019;8 (9) [PubMed]
• Prasetyanti Pramudita R. Development of patient-derived models to study tumor heterogeneity: Studies of colorectal cancer 2019. 215p. ISBN 9789461829436. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Medema J. P.; Co-supervisor: Vermeulen L.)
• Zhao Linjie, Wang Wei, Xu Lian, Yi Tao, Zhao Xia, Wei Yuquan, Vermeulen Louis, Goel Ajay, Zhou Shengtao, Wang Xin Integrative network biology analysis identifies miR-508-3p as the determinant for the mesenchymal identity and a strong prognostic biomarker of ovarian cancer Oncogene 2019;38 (13):2305-2319 [PubMed]
• Sandberg Tessa P., Sweere Iris, van Pelt Gabi W., Putter Hein, Vermeulen Louis, Kuppen Peter J., Tollenaar Rob A. E. M., Mesker Wilma E. Prognostic value of low CDX2 expression in colorectal cancers with a high stromal content – a short report Cellular oncology 2019 [PubMed]
• van der Heijden Maartje, Miedema Daniël M., Waclaw Bartlomiej, Veenstra Veronique L., Lecca Maria C., Nijman Lisanne E., van Dijk Erik, van Neerven Sanne M., Lodestijn Sophie C., Lenos Kristiaan J., de Groot Nina E., Prasetyanti Pramudita R., Varea Andrea Arricibita, Winton Douglas J., Medema Jan Paul, Morrissey Edward, Ylstra Bauke, Nowak Martin A., Bijlsma Maarten F., Vermeulen Louis Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts Proceedings of the National Academy of Sciences of the United States of America 2019;116 (13):6140-6145 [PubMed]
• van der Heijden Maartje, Vermeulen Louis Stem cells in homeostasis and cancer of the gut Molecular cancer 2019;18 (1):66 [PubMed]
• van Neerven Sanne M., Vermeulen Louis The interplay between intrinsic and extrinsic Wnt signaling in controlling intestinal transformation Differentiation; research in biological diversity 2019;108:17-23 [PubMed]

2018

• ten Hoorn Sanne, Trinh Anne, de Jong Joan, Koens Lianne, Vermeulen Louis Classification of colorectal cancer in molecular subtypes by immunohistochemistryin: Methods in Molecular Biology. Humana Press Inc.; 2018. p. 179-191
• Linnekamp Janneke F., van Hooff Sander R., Prasetyanti Pramudita R., Kandimalla Raju, Buikhuisen Joyce Y., Fessler Evelyn, Ramesh Prashanthi, Lee Kelly A. S. T., Bochove Grehor G. W., de Jong Johan H., Cameron Kate, van Leersum Ronald, Rodermond Hans M., Franitza Marek, Nürnberg Peter, Mangiapane Laura R., Wang Xin, Clevers Hans, Vermeulen Louis, Stassi Giorgio, Medema Jan Paul Consensus molecular subtypes of colorectal cancer are recapitulated in in vitro and in vivo models Cell death and differentiation 2018;25:616-633 [PubMed]
• Buczacki Simon J. A., Popova Semiramis, Biggs Emma, Koukorava Chrysa, Buzzelli Jon, Vermeulen Louis, Hazelwood Lee, Francies Hayley, Garnett Mathew J., Winton Douglas J. Itraconazole targets cell cycle heterogeneity in colorectal cancer Journal of experimental medicine 2018;215 (7):1891-1912 [PubMed]
• Lenos Kristiaan J., Miedema Daniël M., Lodestijn Sophie C., Nijman Lisanne E., van den Bosch Tom, Romero Ros Xavier, Lourenço Filipe C., Lecca Maria C., van der Heijden Maartje, van Neerven Sanne M., van Oort Anita, Leveille Nicolas, Adam Ronja S., de Sousa e Melo Felipe, Otten Joy, Veerman Patrick, Hypolite Guillaume, Koens Lianne, Lyons Scott K., Stassi Giorgio, Winton Douglas J., Medema Jan Paul, Morrissey Edward, Bijlsma Maarten F., Vermeulen Louis Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer Nature cell biology 2018;20 (10):1193-1202 [PubMed]
• Trinh Anne, Lädrach Claudia, Dawson Heather E., ten Hoorn Sanne, Kuppen Peter J. K., Reimers Marlies S., Koopman Miriam, Punt Cornelis J. A., Lugli Alessandro, Vermeulen Louis, Zlobec Inti Tumour budding is associated with the mesenchymal colon cancer subtype and RAS/RAF mutations: a study of 1320 colorectal cancers with Consensus Molecular Subgroup (CMS) data British journal of cancer 2018;119 (10):1244-1251 [PubMed]
• Ros Xavier Romero, Vermeulen Louis Turning Cold Tumors Hot by Blocking TGF-β Trends in cancer 2018;4 (5):335-337 [PubMed]
• De Mello Ramon Andrade, Castelo-Branco Luis, Castelo-Branco Pedro, Pozza Daniel Humberto, Vermeulen Louis, Palacio Sofia, Salzberg Matthew, Lockhart A Craig What Will We Expect From Novel Therapies to Esophageal and Gastric Malignancies? American Society of Clinical Oncology educational book / ASCO. American Society of Clinical Oncology. Meeting 2018 (38):249-261 [PubMed]
• Krajewska Julia, Vermeulen Louis Young GI angle: how to write a good conference abstract United European gastroenterology journal 2018;6 (3):482-484 [PubMed]

2017

• van Neerven Sanne M., Vermeulen Louis Balancing signals in the intestinal niche EMBO journal 2017;36 (4):389-391 [PubMed]
• Than B. L. N., Linnekamp J. F., Starr T. K., Largaespada D. A., Rod A., Zhang Y., Bruner V., Abrahante J., Schumann A., Luczak T., Walter J., Niemczyk A., O'Sullivan M. G., Medema J. P., Fijneman R. J. A., Meijer G. A., van den Broek E., Hodges C. A., Scott P. M., Vermeulen L., Cormier R. T. CFTR is a tumor suppressor gene in murine and human intestinal cancer Oncogene 2017;36 (24):3504 [PubMed]
• Dienstmann Rodrigo, Vermeulen Louis, Guinney Justin, Kopetz Scott, Tejpar Sabine, Tabernero Josep Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer Nature reviews. Cancer 2017;17 (2):79-92 [PubMed]
• Ebbing Eva A., Steins Anne, Fessler Evelyn, Stathi Phylicia, Lesterhuis Willem Joost, Krishnadath Kausilia K., Vermeulen Louis, Medema Jan Paul, Bijlsma Maarten F., van Laarhoven Hanneke W. M. Esophageal Adenocarcinoma Cells and Xenograft Tumors Exposed to Erb-b2 Receptor Tyrosine Kinase 2 and 3 Inhibitors Activate Transforming Growth Factor Beta Signaling, Which Induces Epithelial to Mesenchymal Transition Gastroenterology 2017;153 (1):63-76.e14 [PubMed]
• Punt Cornelis J. A., Koopman Miriam, Vermeulen Louis From tumour heterogeneity to advances in precision treatment of colorectal cancer Nature reviews. Clinical oncology 2017;14 (4):235-246 [PubMed]
• Roelands Jessica, Kuppen Peter J. K., Vermeulen Louis, Maccalli Cristina, Decock Julie, Wang Ena, Marincola Francesco M., Bedognetti Davide, Hendrickx Wouter Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications International journal of molecular sciences 2017;18 (10):2229 [PubMed]
• Bijlsma Maarten F., Sadanandam Anguraj, Tan Patrick, Vermeulen Louis Molecular subtypes in cancers of the gastrointestinal tract Nature reviews. Gastroenterology & hepatology 2017;14 (6):333-342 [PubMed]
• Trumpi K., Ubink I., Trinh A., Djafarihamedani M., Jongen J. M., Govaert K. M., Elias S. G., van Hooff S. R., Medema J. P., Lacle M. M., Vermeulen L., Borel Rinkes I. H. M., Kranenburg O. Neoadjuvant chemotherapy affects molecular classification of colorectal tumors Oncogenesis 2017;6 (7):e357 [PubMed]
• Trinh Anne, Trumpi Kari, de Sousa E Melo Felipe, Wang Xin, de Jong Joan H., Fessler Evelyn, Kuppen Peter J. K., Reimers Marlies S., Swets Marloes, Koopman Miriam, Nagtegaal Iris D., Jansen Marnix, Hooijer Gerrit K. J., Offerhaus George J. A., Kranenburg Onno, Punt Cornelis J., Medema Jan Paul, Markowetz Florian, Vermeulen Louis Practical and Robust Identification of Molecular Subtypes in Colorectal Cancer by Immunohistochemistry Clinical cancer research 2017;23 (2):387-398 [PubMed]
• van der Heijden Maartje, Vermeulen Louis Stem Cells: All that Is Solid Melts into Air Cell stem cell 2017;21 (1):5-7 [PubMed]

2016

• Fessler E., Jansen M., de Sousa E Melo F., Zhao L., Prasetyanti P. R., Rodermond H., Kandimalla R., Linnekamp J. F., Franitza M., van Hooff S. R., de Jong J. H., Oppeneer S. C., van Noesel C. J. M., Dekker E., Stassi G., Wang X., Medema J. P., Vermeulen L. A multidimensional network approach reveals microRNAs as determinants of the mesenchymal colorectal cancer subtype Oncogene 2016;35 (46):6026-6037 [PubMed]
• van der Heijden Maartje, Zimberlin Cheryl D., Nicholson Anna M., Colak Selcuk, Kemp Richard, Meijer Sybren L., Medema Jan Paul, Greten Florian R., Jansen Marnix, Winton Douglas J., Vermeulen Louis Bcl-2 is a critical mediator of intestinal transformation Nature communications 2016;7:10916 [PubMed]
• van Neerven Sanne M., Tieken Mathijs, Vermeulen Louis, Bijlsma Maarten F. Bidirectional interconversion of stem and non-stem cancer cell populations: A reassessment of theoretical models for tumor heterogeneity Molecular & cellular oncology 2016;3 (2):UNSP e1098791 [PubMed]
• Lenos Kristiaan J., Vermeulen Louis Cancer stem cells don't waste their time cleaning-low proteasome activity, a marker for cancer stem cell function Annals of translational medicine 2016;4 (24):519 [PubMed]
• Than B. L. N., Linnekamp J. F., Starr T. K., Largaespada D. A., Rod A., Zhang Y., Bruner V., Abrahante J., Schumann A., Luczak T., Niemczyk A., O'Sullivan M. G., Medema J. P., Fijneman R. J. A., Meijer G. A., van den Broek E., Hodges C. A., Scott P. M., Vermeulen L., Cormier R. T. CFTR is a tumor suppressor gene in murine and human intestinal cancer Oncogene 2016;35 (32):4179-4187 [PubMed]
• Vellinga T. T., den Uil S., Rinkes I. H. B., Marvin D., Ponsioen B., Alvarez-Varela A., Fatrai S., Scheele C., Zwijnenburg D. A., Snippert H., Vermeulen L., Medema J. P., Stockmann H. B., Koster J., Fijneman R. J. A., de Rooij J., Kranenburg O. Collagen-rich stroma in aggressive colon tumors induces mesenchymal gene expression and tumor cell invasion Oncogene 2016;35 (40):5263-5271 [PubMed]
• Zimberlin Cheryl D. Crossing Borders: Manipulating stemness through carcinogenesis 2016. 221p. ISBN 9789461826763. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Medema J. P.; Co-supervisors: Vermeulen L., Bots M.)
• Fessler Evelyn Exploring tumor heterogeneity 2016. 196p. ISBN 9789462953796. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Medema J. P.; Co-supervisor: Vermeulen L.)
• den Uil Sjoerd H., Coupé Veerle M. H., Linnekamp Janneke F., van den Broek Evert, Goos Jeroen A. C. M., Delis-van Diemen Pien M., Belt Eric J. Th, van Grieken Nicole C. T., Scott Patricia M., Vermeulen Louis, Medema Jan Paul, Bril Herman, Stockmann Hein B. A. C., Cormier Robert T., Meijer Gerrit A., Fijneman Remond J. A. Loss of KCNQ1 expression in stage II and stage III colon cancer is a strong prognostic factor for disease recurrence British journal of cancer 2016;115 (12):1565-1574 [PubMed]
• Léveillé Nicolas, Vermeulen Louis Polycomb complex PRC1 as gatekeeper of intestinal stem cell identity Stem cell investigation 2016;3:22 [PubMed]
• Domingo Enric, Freeman-Mills Luke, Rayner Emily, Glaire Mark, Briggs Sarah, Vermeulen Louis, Fessler Evelyn, Medema Jan Paul, Boot Arnoud, Morreau Hans, van Wezel Tom, Liefers Gerrit-Jan, Lothe Ragnhild A., Danielsen Stine A., Sveen Anita, Nesbakken Arild, Zlobec Inti, Lugli Alessandro, Koelzer Viktor H., Berger Martin D., Castellví-Bel Sergi, Muñoz Jenifer, de Bruyn Marco, Nijman Hans W., Novelli Marco, Lawson Kay, Oukrif Dahmane, Frangou Eleni, Dutton Peter, Tejpar Sabine, Delorenzi Mauro, Kerr Rachel, Kerr David, Tomlinson Ian, Church David N. Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study lancet. Gastroenterology & hepatology 2016;1 (3):207-216 [PubMed]
• Fessler Evelyn, Drost Jarno, van Hooff Sander R., Linnekamp Janneke F., Wang Xin, Jansen Marnix, de Sousa E Melo Felipe, Prasetyanti Pramudita R., IJspeert Joep Eg, Franitza Marek, Nürnberg Peter, van Noesel Carel Jm, Dekker Evelien, Vermeulen Louis, Clevers Hans, Medema Jan Paul TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype EMBO molecular medicine 2016;8 (7):745-760 [PubMed]
• Habeeb Nicole White-Al, Kulasingam Vathany, Diamandis Eleftherios P., Yousef George M., Tsongalis Gregory J., Vermeulen Louis, Zhu Ziqiang, Kamel-Reid Suzanne The Use of Targeted Therapies for Precision Medicine in Oncology Clinical chemistry 2016;62 (12):1556-1564 [PubMed]
• van der Heijden Maartje, Winton Douglas J., Vermeulen Louis Turning off the BCL-2 switch to prevent intestinal tumorigenesis Oncotarget 2016;7 (20):28763-28764 [PubMed]
• de Sousa E Melo Felipe, Vermeulen Louis Wnt Signaling in Cancer Stem Cell Biology Cancers 2016;8 (7):60 [PubMed]

2015

• Goodson William H., Lowe Leroy, Carpenter David O., Gilbertson Michael, Manaf Ali Abdul, Lopez de Cerain Salsamendi Adela, Lasfar Ahmed, Carnero Amancio, Azqueta Amaya, Amedei Amedeo, Charles Amelia K., Collins Andrew R., Ward Andrew, Salzberg Anna C., Colacci Annamaria, Olsen Ann-Karin, Berg Arthur, Barclay Barry J., Zhou Binhua P., Blanco-Aparicio Carmen, Baglole Carolyn J., Dong Chenfang, Mondello Chiara, Hsu Chia-Wen, Naus Christian C., Yedjou Clement, Curran Colleen S., Laird Dale W., Koch Daniel C., Carlin Danielle J., Felsher Dean W., Roy Debasish, Brown Dustin G., Ratovitski Edward, Ryan Elizabeth P., Corsini Emanuela, Rojas Emilio, Moon Eun-Yi, Laconi Ezio, Marongiu Fabio, Al-Mulla Fahd, Chiaradonna Ferdinando, Darroudi Firouz, Martin Francis L., van Schooten Frederik J., Goldberg Gary S., Wagemaker Gerard, Nangami Gladys N., Calaf Gloria M., Williams Graeme, Wolf Gregory T., Koppen Gudrun, Brunborg Gunnar, Lyerly H. Kim, Krishnan Harini, Ab Hamid Hasiah, Yasaei Hemad, Sone Hideko, Kondoh Hiroshi, Salem Hosni K., Hsu Hsue-Yin, Park Hyun Ho, Koturbash Igor, Miousse Isabelle R., Scovassi A. Ivana, Klaunig James E., Vondráček Jan, Raju Jayadev, Roman Jesse, Wise John Pierce, Whitfield Jonathan R., Woodrick Jordan, Christopher Joseph A., Ochieng Josiah, Martinez-Leal Juan Fernando, Weisz Judith, Kravchenko Julia, Sun Jun, Prudhomme Kalan R., Narayanan Kannan Badri, Cohen-Solal Karine A., Moorwood Kim, Gonzalez Laetitia, Soucek Laura, Jian Le, D'Abronzo Leandro S., Lin Liang-Tzung, Li Lin, Gulliver Linda, McCawley Lisa J., Memeo Lorenzo, Vermeulen Louis, Leyns Luc, Zhang Luoping, Valverde Mahara, Khatami Mahin, Romano Maria Fiammetta, Chapellier Marion, Williams Marc A., Wade Mark, Manjili Masoud H., Lleonart Matilde E., Xia Menghang, Gonzalez Michael J., Karamouzis Michalis V., Kirsch-Volders Micheline, Vaccari Monica, Kuemmerle Nancy B., Singh Neetu, Cruickshanks Nichola, Kleinstreuer Nicole, van Larebeke Nik, Ahmed Nuzhat, Ogunkua Olugbemiga, Krishnakumar P. K., Vadgama Pankaj, Marignani Paola A., Ghosh Paramita M., Ostrosky-Wegman Patricia, Thompson Patricia A., Dent Paul, Heneberg Petr, Darbre Philippa, Sing Leung Po, Nangia-Makker Pratima, Cheng Qiang Shawn, Robey R. Brooks, Al-Temaimi Rabeah, Roy Rabindra, Andrade-Vieira Rafaela, Sinha Ranjeet K., Mehta Rekha, Vento Renza, Di Fiore Riccardo, Ponce-Cusi Richard, Dornetshuber-Fleiss Rita, Nahta Rita, Castellino Robert C., Palorini Roberta, Abd Hamid Roslida, Langie Sabine A. S., Eltom Sakina E., Brooks Samira A., Ryeom Sandra, Wise Sandra S., Bay Sarah N., Harris Shelley A., Papagerakis Silvana, Romano Simona, Pavanello Sofia, Eriksson Staffan, Forte Stefano, Casey Stephanie C., Luanpitpong Sudjit, Lee Tae-Jin, Otsuki Takemi, Chen Tao, Massfelder Thierry, Sanderson Thomas, Guarnieri Tiziana, Hultman Tove, Dormoy Valérian, Odero-Marah Valerie, Sabbisetti Venkata, Maguer-Satta Veronique, Rathmell W. Kimryn, Engström Wilhelm, Decker William K., Bisson William H., Rojanasakul Yon, Luqmani Yunus, Chen Zhenbang, Hu Zhiwei Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead Carcinogenesis 2015;36 (Suppl. 1):S254-S296 [PubMed]
• Linnekamp Janneke F., Wang Xin, Medema Jan Paul, Vermeulen Louis Colorectal cancer heterogeneity and targeted therapy: a case for molecular disease subtypes Cancer research 2015;75 (2):245-249 [PubMed]
• Wielenga Mattheus C. B., Colak Selcuk, Heijmans Jarom, van Lidth de Jeude Jooske F., Rodermond Hans M., Paton James C., Paton Adrienne W., Vermeulen Louis, Medema Jan Paul, van den Brink Gijs R. ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy Cell reports 2015;13 (3):490-494 [PubMed]
• IJspeert Joep E. G., Vermeulen Louis, Meijer Gerrit A., Dekker Evelien Serrated neoplasia-role in colorectal carcinogenesis and clinical implications Nature reviews. Gastroenterology & hepatology 2015;12 (7):401-409 [PubMed]
• Guinney Justin, Dienstmann Rodrigo, Wang Xin, de Reyniès Aurélien, Schlicker Andreas, Soneson Charlotte, Marisa Laetitia, Roepman Paul, Nyamundanda Gift, Angelino Paolo, Bot Brian M., Morris Jeffrey S., Simon Iris M., Gerster Sarah, Fessler Evelyn, de Sousa E Melo Felipe, Missiaglia Edoardo, Ramay Hena, Barras David, Homicsko Krisztian, Maru Dipen, Manyam Ganiraju C., Broom Bradley, Boige Valerie, Perez-Villamil Beatriz, Laderas Ted, Salazar Ramon, Gray Joe W., Hanahan Douglas, Tabernero Josep, Bernards Rene, Friend Stephen H., Laurent-Puig Pierre, Medema Jan Paul, Sadanandam Anguraj, Wessels Lodewyk, Delorenzi Mauro, Kopetz Scott, Vermeulen Louis, Tejpar Sabine The consensus molecular subtypes of colorectal cancer Nature medicine 2015;21 (11):1350-1356 [PubMed]
• Casey Stephanie C., Vaccari Monica, Al-Mulla Fahd, Al-Temaimi Rabeah, Amedei Amedeo, Barcellos-Hoff Mary Helen, Brown Dustin G., Chapellier Marion, Christopher Joseph, Curran Colleen S., Forte Stefano, Hamid Roslida A., Heneberg Petr, Koch Daniel C., Krishnakumar P. K., Laconi Ezio, Maguer-Satta Veronique, Marongiu Fabio, Memeo Lorenzo, Mondello Chiara, Raju Jayadev, Roman Jesse, Roy Rabindra, Ryan Elizabeth P., Ryeom Sandra, Salem Hosni K., Scovassi A. Ivana, Singh Neetu, Soucek Laura, Vermeulen Louis, Whitfield Jonathan R., Woodrick Jordan, Colacci Annamaria, Bisson William H., Felsher Dean W. The effect of environmental chemicals on the tumor microenvironment Carcinogenesis 2015;36 (Suppl. 1):S160-S183 [PubMed]

2014

• Sadanandam Anguraj, Wang Xin, de Sousa E Melo Felipe, Gray Joe W., Vermeulen Louis, Hanahan Douglas, Medema Jan Paul Reconciliation of classification systems defining molecular subtypes of colorectal cancer: interrelationships and clinical implications Cell cycle (Georgetown, Tex.) 2014;13 (3):353-357 [PubMed]
• Morrissey Edward R., Vermeulen Louis Stem cell competition: how speeding mutants beat the rest EMBO journal 2014;33 (20):2277-2278 [PubMed]
• Vermeulen Louis, Snippert Hugo J. Stem cell dynamics in homeostasis and cancer of the intestine Nature reviews. Cancer 2014;14 (7):468-480 [PubMed]

2013

• de Sousa E Melo Felipe, Vermeulen Louis, Fessler Evelyn, Medema Jan Paul Cancer heterogeneity--a multifaceted view EMBO reports 2013;14 (8):686-695 [PubMed]
• Zeilstra Jurrit, Joosten Sander P. J., Vermeulen Louis, Koster Jan, Medema Jan Paul, Versteeg Rogier, Spaargaren Marcel, Pals Steven T. CD44 expression in intestinal epithelium and colorectal cancer is independent of p53 status PLoS ONE 2013;8 (8):e72849 [PubMed]
• de Sousa E Melo Felipe Colon cancer heterogeneity: stem cells, signals and subtypes 2013. 203p. ISBN 9878946182326. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Medema J. P.; Co-supervisor: Vermeulen L.)
• Kozar Sarah, Morrissey Edward, Nicholson Anna M., van der Heijden Maartje, Zecchini Heather I., Kemp Richard, Tavaré Simon, Vermeulen Louis, Winton Douglas J. Continuous Clonal Labeling Reveals Small Numbers of Functional Stem Cells in Intestinal Crypts and Adenomas Cell stem cell 2013;13 (5):626-633 [PubMed]
• Vermeulen Louis, Morrissey Edward, van der Heijden Maartje, Nicholson Anna M., Sottoriva Andrea, Buczacki Simon, Kemp Richard, Tavaré Simon, Winton Douglas J. Defining Stem Cell Dynamics in Models of Intestinal Tumor Initiation Science 2013;342 (6161):995-998 [PubMed]
• Vermeulen L., Medema J. P. De pathogenese van dikkedarmkankerin: C. J. A. Punt, C. A. M. Marijnen, I. D. Nagtegaal, C. J. H. van de Velde, editors. Handboek colorectaal carcinoom. Utrecht: De Tijdstroom; 2013. p. 37-46, ISBN 9789058981967
• Wang Xin, Markowetz Florian, de Sousa E Melo Felipe, Medema Jan Paul, Vermeulen Louis Dissecting cancer heterogeneity--an unsupervised classification approach international journal of biochemistry & cell biology 2013;45 (11):2574-2579 [PubMed]
• Buczacki Simon J. A., Zecchini Heather Ireland, Nicholson Anna M., Russell Roslin, Vermeulen Louis, Kemp Richard, Winton Douglas J. Intestinal label-retaining cells are secretory precursors expressing Lgr5 Nature 2013;495 (7439):65-69 [PubMed]
• Vermeulen Louis Keeping Stem Cells in Check: A Hippo Balancing Act Cell stem cell 2013;12 (1):3-5 [PubMed]
• de Sousa E Melo Felipe, Wang Xin, Jansen Marnix, Fessler Evelyn, Trinh Anne, de Rooij Laura P. M. H., de Jong Joan H., de Boer Onno J., van Leersum Ronald, Bijlsma Maarten F., Rodermond Hans, van der Heijden Maartje, van Noesel Carel J. M., Tuynman Jurriaan B., Dekker Evelien, Markowetz Florian, Medema Jan Paul, Vermeulen Louis Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions Nature medicine 2013;19 (5):614-618 [PubMed]
• Prasetyanti Pramudita Ramadhina, Zimberlin Cheryl Doreen, Bots Michael, Vermeulen Louis, Melo Felipe De Sousa E., Medema Jan Paul Regulation of stem cell self-renewal and differentiation by Wnt and Notch are conserved throughout the adenoma-carcinoma sequence in the colon Molecular cancer 2013;12 (1):126 [PubMed]

2012

• de Jong Joan H., Rodermond Hans M., Zimberlin Cheryl D., Lascano Valeria, de Sousa E Melo Felipe, Richel Dick J., Medema Jan Paul, Vermeulen Louis Fusion of intestinal epithelial cells with bone marrow derived cells is dispensable for tissue homeostasis Scientific reports 2012;2:271 [PubMed]
• Kemper Kristel, Versloot Miranda, Cameron Katherine, Colak Selçuk, de Sousa E Melo Felipe, de Jong Joan H., Bleackley Joanne, Vermeulen Louis, Versteeg Rogier, Koster Jan, Medema Jan Paul Mutations in the Ras-Raf Axis Underlie the Prognostic Value of CD133 in Colorectal Cancer Clinical cancer research 2012;18 (11):3132-3141 [PubMed]
• Vermeulen Louis, de Sousa E Melo Felipe, Richel Dick J., Medema Jan Paul The developing cancer stem-cell model: clinical challenges and opportunities lancet oncology 2012;13 (2):E83-E89 [PubMed]

2011

• Borovski Tijana, de Sousa E Melo Felipe, Vermeulen Louis, Medema Jan Paul Cancer Stem Cell Niche: The Place to Be Cancer research 2011;71 (3):634-639 [PubMed]
• de Sousa E Melo F., Guessous I., Vermeulen L., Medema J. P. Cellules souches cancéreuses et futures modalités thérapeutiques du cancer Revue medicale suisse 2011;7 (289):774-777 [PubMed]
• de Sousa E Melo Felipe, Colak Selcuk, Buikhuisen Joyce, Koster Jan, Cameron Kate, de Jong Joan H., Tuynman Jurriaan B., Prasetyanti Pramudita R., Fessler Evelyn, van den Bergh Saskia P., Rodermond Hans, Dekker Evelien, van der Loos Chris M., Pals Steven T., van de Vijver Marc J., Versteeg Rogier, Richel Dick J., Vermeulen Louis, Medema Jan Paul Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients Cell stem cell 2011;9 (5):476-485 [PubMed]
• Medema Jan Paul, Vermeulen Louis Microenvironmental regulation of stem cells in intestinal homeostasis and cancer Nature 2011;474 (7351):318-326 [PubMed]
• Sottoriva Andrea, Vermeulen Louis, Tavaré Simon Modeling evolutionary dynamics of epigenetic mutations in hierarchically organized tumors PLoS computational biology 2011;7 (5):e1001132 [PubMed]
• de Sousa E Melo Felipe, Vermeulen Louis, Richel Dick, Medema Jan Paul Targeting Wnt Signaling in Colon Cancer Stem Cells Clinical cancer research 2011;17 (4):647-653 [PubMed]

2010

• Vermeulen Louis Cancer stem cells - a numbers game? 2010. 224p. ISBN 9789090257105. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Medema J. P., Richel D. J.)
• Sottoriva Andrea, Verhoeff Joost J. C., Borovski Tijana, McWeeney Shannon K., Naumov Lev, Medema Jan Paul, Sloot Peter M. A., Vermeulen Louis Cancer Stem Cell Tumor Model Reveals Invasive Morphology and Increased Phenotypical Heterogeneity Cancer research 2010;70 (1):46-56 [PubMed]
• Sottoriva Andrea, Sloot Peter M. A., Medema Jan Paul, Vermeulen Louis Exploring cancer stem cell niche directed tumor growth Cell cycle (Georgetown, Tex.) 2010;9 (8):1472-1479 [PubMed]
• Kemper Kristel, Sprick Martin R., de Bree Martijn, Scopelliti Alessandro, Vermeulen Louis, Hoek Maarten, Zeilstra Jurrit, Pals Steven T., Mehmet Huseyin, Stassi Giorgio, Medema Jan Paul The AC133 Epitope, but not the CD133 Protein, Is Lost upon Cancer Stem Cell Differentiation Cancer research 2010;70 (2):719-729 [PubMed]
• Vermeulen Louis, de Sousa E Melo Felipe, van der Heijden Maartje, Cameron Kate, de Jong Joan H., Borovski Tijana, Tuynman Jurriaan B., Todaro Matilde, Merz Christian, Rodermond Hans, Sprick Martin R., Kemper Kristel, Richel Dick J., Stassi Giorgio, Medema Jan Paul Wnt activity defines colon cancer stem cells and is regulated by the microenvironment Nature cell biology 2010;12 (5):468-U121 [PubMed]

2009

• Vermeulen Louis, Medema Jan Paul, Hardwick James C. H., van den Brink Gijs R. Cancer Stem Cells in Colorectal Cancerin: Sadhan Majumder, editors. Stem Cells and Cancer. Berlin; New York: Springer; 2009. p. 233-250, ISBN 9780387896113; 9780387896106
• Vermeulen Louis, Verhoeff Joost J. C., Richel Dick J., Medema Jan Paul Kankerstamcellen Nederlands tijdschrift voor geneeskunde 2009;153 (7):286-290 [PubMed]
• Borovski Tijana, Vermeulen L., Sprick M. R., Medema J. P. One renegade cancer stem cell? Cell cycle (Georgetown, Tex.) 2009;8 (6):803-808 [PubMed]
• Vermeulen L., Todaro M., De Sousa Mello F., Sprick M. R., Kemper K., Perez Alea M., Richel D. J., Stassi G., Medema J. P. Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity (Proceedings of the National Academy of Sciences of the United States of America (2008) 105, 36, (13427-13432) DOI 10.1073/pnas. 0805706105) Proceedings of the National Academy of Sciences of the United States of America 2009;106 (23):9534

2008

• Vermeulen L., Sprick M. R., Kemper K., Stassi G., Medema J. P. Cancer stem cells--old concepts, new insights Cell death and differentiation 2008;15 (6):947-958 [PubMed]
• Tuynman Jurriaan B., Vermeulen Louis, Boon Elles M., Kemper Kristel, Zwinderman Aeilko H., Peppelenbosch Maikel P., Richel Dirk J. Cyclooxygenase-2 inhibition inhibits c-Met kinase activity and Wnt activity in colon cancer Cancer research 2008;68 (4):1213-1220 [PubMed]
• Vermeulen L., Todaro M., de Sousa E Melo F., Sprick M. R., Kemper K., Alea M. Perez, Richel D. J., Stassi G., Medema J. P. Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity Proceedings of the National Academy of Sciences of the United States of America 2008;105 (36):13427-13432 [PubMed]

2007

• Todaro Matilde, Alea Mileidys Perez, Di Stefano Anna B., Cammareri Patrizia, Vermeulen Louis, Iovino Flora, Tripodo Claudio, Russo Antonio, Gulotta Gaspare, Medema Jan Paul, Stassi Giorgio Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4 Cell stem cell 2007;1 (4):389-402 [PubMed]

2006

• Löwenberg Mark, Tuynman Jurriaan, Scheffer Meike, Verhaar Auke, Vermeulen Louis, van Deventer Sander, Hommes Daniel, Peppelenbosch Maikel Kinome analysis reveals nongenomic glucocorticoid receptor-dependent inhibition of insulin signaling Endocrinology 2006;147 (7):3555-3562 [PubMed]