Key publications
All Publications
- van Andel Harmen, Ren Zemin, Koopmans Iris, Joosten Sander P. J., Kocemba Kinga A., de Lau Wim, Kersten Marie José, de Bruin Alexander M., Guikema Jeroen E. J., Clevers Hans, Spaargaren Marcel, Pals Steven T. Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins Proceedings of the National Academy of Sciences of the United States of America 2017;114 (2):376-381 [PubMed]
- van Andel H., Kocemba K. A., de Haan-Kramer A., Mellink C. H., Piwowar M., Broijl A., van Duin M., Sonneveld P., Maurice M. M., Kersten M. J., Spaargaren M., Pals S. T. Loss of CYLD expression unleashes Wnt signaling in multiple myeloma and is associated with aggressive disease Oncogene 2017;36 (15):2105-2115 [PubMed]
- Joosten Sander P. J., Zeilstra Jurrit, van Andel Harmen, Mijnals R. Clinton, Zaunbrecher Joost, Duivenvoorden Annet A. M., van de Wetering Marc, Clevers Hans, Spaargaren Marcel, Pals Steven T. MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms Gastroenterology 2017;153 (4):1040-+ [PubMed]
- Kraan W., van Keimpema M., Horlings H. M., Schilder-Tol E. J. M., Oud M. E. C. M., Noorduyn L. A., Kluin P. M., Kersten M. J., Spaargaren M., Pals S. T. High prevalence of oncogenic MYD88 and CD79B mutations in primary testicular diffuse large B-cell lymphoma Leukemia 2014;28 (3):719-720 [PubMed]
- de Rooij Martin F. M., Kuil Annemieke, Geest Christian R., Eldering Eric, Chang Betty Y., Buggy Joseph J., Pals Steven T., Spaargaren Marcel The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia Blood 2012;119 (11):2590-2594 [PubMed]
Research programmes
Prof. MD PhD S.T. Pals (“B-cell development and neoplasia”)
-Molecular and Functional Analysis of WNT Signaling in Multiple Myeloma and Non-Hodgkin Lymphoma (supported by Dutch Cancer Society).
-Syndecan-1 and modifications of its heparan sulfate chains in Multiple Myeloma (supported by Dutch Cancer Society)
-Provoking homelessness to cure lymphoma and myeloma (supported by Lymph&Co, Dutch Cancer Society and IWMF)
Postdocs
PhD A.M. de Bruin
Others
BEng L.J. Gruneberg
BSc W. Kraan
BEng A. Kuil
M.E.C.M. Ursem-Oud