Prof. E.F. Eldering PhD

Prof. PhD E.F. Eldering

Position

Full Professor

Main activities

Research

Specialisation

Immuno-Hematology

Focus of research

The group of Eric Eldering at the Dept of Experimental Immunology of the AMC works on apoptosis regulation in normal and pathological immune cells. We apply cellular, biochemical and molecular biology techniques in human cells and mouse models, in two main research lines. The first concerns translational research into leukemia, driven by clinical problems, in close collaboration with prof Arnon Kater (Dept of Hematology, AMC). We have studied apoptosis (dys)regulation in B cells since 2002, subsequently focusing on Chronic Lymphocytic Leukemia (CLL). We currently study three aspects of CLL biology:
1. CLL functional genetics and molecular diagnostics
2. The leukemic micro-environment, apoptosis dysregulation and novel drugs
3. Interaction between the immune system and CLL with focus on immune metabolism

Second is a research line devoted to more fundamental immunological issues.We have studied the role of Bcl-2 family members in T and B cells during initiation of the immune response. Bcl-2 members Noxa and Mcl-1 control outgrowth of high affinity lymphocytes as well as clonal diversity. Currently we are studying interactions among Bcl-2 family members using a novel technique called BH3 mimetic profiling (Peperzak 2017). The ultimate goal of this research is to apply the insight obtained in novel vaccination and anti-cancer strategies.

In 2014, three NWO Veni laureates have started their own projects: Felix Wensveen studies selection of high affinity T and B cells (finished January 2017), Victor Peperzak investigates regulation of pro-survival Mcl-1 in malignant B cells (moved to UMC Utrecht in Nov 2015), and Rianne van der Windt studies Immunometabolism, which has become an integral part of our Hemato-Oncology research line.

Amsterdam UMC Research Institutes

AMC departments

Experimental Immunology

Key publications

Pascutti Maria Fernanda, Jak Margot, Tromp Jacqueline M., Derks Ingrid A. M., Remmerswaal Ester B. M., Thijssen Rachel, van Attekum Martijn H. A., van Bochove Gregor G., Luijks Dieuwertje M., Pals Steven T., van Lier René A. W., Kater Arnon P., van Oers Marinus H. J., Eldering Eric IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells Blood 2013;122 (17):3010-3019 [PubMed]
Tromp Jacqueline M., Geest Christian R., Breij Esther C. W., Elias Judith A., van Laar Jacoline, Luijks Dieuwertje M., Kater Arnon P., Beaumont Tim, van Oers Marinus H. J., Eldering Eric Tipping the Noxa/Mcl-1 Balance Overcomes ABT-737 Resistance in Chronic Lymphocytic Leukemia Clinical cancer research 2012;18 (2):487-498 [PubMed]
te Raa G. D., Derks I. A. M., Navrkalova V., Skowronska A., Moerland P. D., van Laar J., Oldreive C., Monsuur H., Trbusek M., Malcikova J., Lodén M., Geisler C. H., Hüllein J., Jethwa A., Zenz T., Pospisilova S., Stankovic T., van Oers M. H. J., Kater A. P., Eldering E. The impact of SF3B1 mutations in CLL on the DNA-damage response Leukemia 2015;29 (5):1133-1142 [PubMed]
Thijssen Rachel, ter Burg Johanna, Garrick Brett, van Bochove Gregor G. W., Brown Jennifer R., Fernandes Stacey M., Rodríguez María Solé, Michot Jean-Marie, Hallek Michael, Eichhorst Barbara, Reinhardt Hans Christian, Bendell Johanna, Derks Ingrid A. M., van Kampen Roel J. W., Hege Kristen, Kersten Marie José, Trowe Torsten, Filvaroff Ellen H., Eldering Eric, Kater Arnon P. Dual TORK/DNA-PK inhibition blocks critical signaling pathways in chronic lymphocytic leukemia Blood 2016;128 (4):574-583 [PubMed]
Thijssen Rachel, Slinger Erik, Weller Katinka, Geest Christian R., Beaumont Tim, van Oers Marinus H. J., Kater Arnon P., Eldering Eric Resistance to ABT-199 induced by microenvironmental signals in chronic lymphocytic leukemia can be counteracted by CD20 antibodies or kinase inhibitors Haematologica 2015;100 (8):e302-e306 [PubMed]