Prof. J.P. Medema PhD publications

2021

• Pickering K. A., Gilroy K., Cassidy J. W., Fey S. K., Najumudeen A. K., Zeiger L. B., Vincent D. F., Gay D. M., Johansson J., Fordham R. P., Miller B., Clark W., Hedley A., Unal E. B., Kiel C., McGhee E., Machesky L. M., Nixon C., Johnsson A. E., Bain M., Strathdee D., van Hoof S. R., Medema J. P., Anderson K. I., Brachmann S. M., Stucke V. M., Malliri A., Drysdale M., Turner M., Serrano L., Myant K., Campbell A. D., Sansom O. J. A RAC-GEF network critical for early intestinal tumourigenesis Nature communications 2021;12 (1) [PubMed]
• Mangiapane Laura Rosa, Nicotra Annalisa, Turdo Alice, Gaggianesi Miriam, Bianca Paola, di Franco Simone, Sardina Davide Stefano, Veschi Veronica, Signore Michele, Beyes Sven, Fagnocchi Luca, Fiori Micol Eleonora, Bongiorno Maria Rita, Lo Iacono Melania, Pillitteri Irene, Ganduscio Gloria, Gulotta Gaspare, Medema Jan Paul, Zippo Alessio, Todaro Matilde, de Maria Ruggero, Stassi Giorgio PI3K-driven HER2 expression is a potential therapeutic target in colorectal cancer stem cells Gut 2021 [PubMed]

2020

• Francescangeli Federica, Contavalli Paola, de Angelis Maria Laura, Careccia Silvia, Signore Michele, Haas Tobias Longin, Salaris Federico, Baiocchi Marta, Boe Alessandra, Giuliani Alessandro, Tcheremenskaia Olga, Pagliuca Alfredo, Guardiola Ombretta, Minchiotti Gabriella, Colace Lidia, Ciardi Antonio, D'Andrea Vito, la Torre Filippo, Medema JanPaul, de Maria Ruggero, Zeuner Ann A pre-existing population of ZEB2+ quiescent cells with stemness and mesenchymal features dictate chemoresistance in colorectal cancer Journal of experimental & clinical cancer research 2020;39 (1):2 [PubMed]
• Ramesh Prashanthi, Medema Jan Paul BCL-2 family deregulation in colorectal cancer: potential for BH3 mimetics in therapy Apoptosis 2020;25 (5-6):305-320 [PubMed]
• van der Heijden M. C. S. Colon cancer dynamics in development, progression and growt 2020. 229p. ISBN 9789463239431. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Vermeulen L. , Medema J.; Co-supervisor: Winton D. J.)
• Smit Wouter Laurentius, Spaan Claudia Nanette, de Boer Ruben Johannes, Ramesh Prashanthi, Garcia T. nia Martins, Meijer Bartolomeus Joannes, Vermeulen Jacqueline Ludovicus Maria, Lezzerini Marco, MacInnes Alyson Winfried, Koster Jan, Medema Jan Paul, van den Brink Gijs Robert, Muncan Vanesa, Heijmans Jarom Driver mutations of the adenoma-carcinoma sequence govern the intestinal epithelial global translational capacity Proceedings of the National Academy of Sciences of the United States of America 2020;117 (41):25560-25570 [PubMed]
• Buikhuisen Joyce Y., Torang Arezo, Medema Jan Paul Exploring and modelling colon cancer inter-tumour heterogeneity: opportunities and challenges Oncogenesis 2020;9 (7) [PubMed]
• Steins Anne, van Mackelenbergh Madelaine G., van der Zalm Amber P., Klaassen Remy, Serrels Bryan, Goris Sandrine G., Kocher Hemant M., Waasdorp Cynthia, de Jong Joan H., Tekin Cansu, Besselink Marc G., Busch Olivier R., van de Vijver Marc J., Verheij Joanne, Dijk Frederike, van Tienhoven Geertjan, Wilmink Johanna W., Medema Jan Paul, van Laarhoven Hanneke W. M., Bijlsma Maarten F. High-grade mesenchymal pancreatic ductal adenocarcinoma drives stromal deactivation through CSF-1 EMBO reports 2020;21 (5) [PubMed]
• van den Berg I., van de Weerd S., Roodhart J. M. L., Vink G. R., van den Braak R. R. J. Coebergh, Jimenez C. R., Elias S. G., van Vliet D., Koelink M., Hong E., van Grevenstein W. M. U., van Oijen M. G. H., Beets-Tan R. G. H., van Krieken J. H. J. M., IJzermans J. N. M., Medema J. P., Koopman M. Improving clinical management of colon cancer through CONNECTION, a nation-wide colon cancer registry and stratification effort (CONNECTION II trial): rationale and protocol of a single arm intervention study BMC cancer 2020;20 (1):776 [PubMed]
• Coebergh van den Braak R. R. J., ten Hoorn S., Sieuwerts A. M., Tuynman J. B., Smid M., Wilting S. M., Martens J. W. M., Punt C. J. A., Foekens J. A., Medema J. P., IJzermans J. N. M., Vermeulen L. Interconnectivity between molecular subtypes and tumor stage in colorectal cancer BMC cancer 2020;20 (1):850 [PubMed]
• Jongeneel Gabrielle, Greuter Marjolein J. E., van Erning Felice N., Koopman Miriam, Medema Jan P., Kandimalla Raju, Goel Ajay, Bujanda Luis, Meijer Gerrit A., Fijneman Remond J. A., van Oijen Martijn G. H., Ijzermans Jan, Punt Cornelis J. A., Vink Geraldine R., Coupé Veerle M. H. Modeling Personalized Adjuvant TreaTment in EaRly stage coloN cancer (PATTERN) European journal of health economics : HEPAC 2020;21 (7):1059-1073 [PubMed]
• Serna Naroa, Álamo Patricia, Ramesh Prashanthi, Vinokurova Daria, Sánchez-García Laura, Unzueta Ugutz, Gallardo Alberto, Céspedes María Virtudes, Vázquez Esther, Villaverde Antonio, Mangues Ramón, Medema Jan Paul Nanostructured toxins for the selective destruction of drug-resistant human CXCR4+ colorectal cancer stem cells Journal of controlled release 2020;320:96-104 [PubMed]
• Steins Anne, Klaassen Remy, Jacobs Igor, Schabel Matthias C., van Lier Monique G. J. T. B., Ebbing Eva A., Hectors Stefanie J., Tas Sander W., Maracle Chrissta X., Punt Cornelis J. A., Siebes Maria, Bergman Jacques J. G. H. M., Medema Jan Paul, Wilmink Johanna W., Mathot Ron A. A., Strijkers Gustav J., Bijlsma Maarten F., van Laarhoven Hanneke W. M. Rapid stromal remodeling by short-term VEGFR2 inhibition increases chemotherapy delivery in esophagogastric adenocarcinoma Molecular oncology 2020;14 (4):704-720 [PubMed]
• Spit Maureen, Fenderico Nicola, Jordens Ingrid, Radaszkiewicz Tomasz, Lindeboom Rik G. H., Bugter Jeroen M., Cristobal Alba, Ootes Lars, van Osch Max, Janssen Eline, Boonekamp Kim E., Hanakova Katerina, Potesil David, Zdrahal Zbynek, Boj Sylvia F., Medema Jan Paul, Bryja Vitezslav, Koo Bon-Kyoung, Vermeulen Michiel, Maurice Madelon M. RNF43 truncations trap CK1 to drive niche-independent self-renewal in cancer EMBO journal 2020;39 (18) [PubMed]
• Steins Anne The role of the tumor microenvironment in tumors of the upper gastrointestinal tract 2020. 311p. ISBN 9789402820980. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van Laarhoven Hanneke W. M., Medema Jan P.; Co-supervisor: Bijlsma Maarten F.)
• Dijk Frederike, Veenstra Veronique L., Soer Eline C., Dings Mark P. G., Zhao Lan, Halfwerk Johannes B., Hooijer Gerrit K., Damhofer Helene, Marzano Marco, Steins Anne, Waasdorp Cynthia, Busch Olivier R., Besselink Marc G., Tol Johanna A., Welling Lieke, van Rijssen Lennart B., Klompmaker Sjors, Wilmink Hanneke W., van Laarhoven Hanneke W., Medema Jan Paul, Vermeulen Louis, van Hooff Sander R., Koster Jan, Verheij Joanne, van de Vijver Marc J., Wang Xin, Bijlsma Maarten F. Unsupervised class discovery in pancreatic ductal adenocarcinoma reveals cell-intrinsic mesenchymal features and high concordance between existing classification systems Scientific reports 2020;10 (1):337 [PubMed]

2019

• Prasetyanti Pramudita R., van Hooff Sander R., van Herwaarden Tessa, de Vries Nathalie, Kalloe Kieshen, Rodermond Hans, van Leersum Ronald, de Jong Joan H., Franitza Marek, Nürnberg Peter, Todaro Matilde, Stassi Giorgio, Medema Jan Paul Capturing colorectal cancer inter-tumor heterogeneity in patient-derived xenograft (PDX) models International journal of cancer. Journal international du cancer 2019;144 (2):366-371 [PubMed]
• Steins Anne, Ebbing Eva A., Creemers Aafke, van der Zalm Amber P., Jibodh Rajni A., Waasdorp Cynthia, Meijer Sybren L., van Delden Otto M., Krishnadath Kausilia K., Hulshof Maarten C. C. M., Bennink Roelof J., Punt Cornelis J. A., Medema Jan Paul, Bijlsma Maarten F., van Laarhoven Hanneke W. M. Chemoradiation induces epithelial-to-mesenchymal transition in esophageal adenocarcinoma International journal of cancer. Journal international du cancer 2019;145 (10):2792-2803 [PubMed]
• Prasetyanti Pramudita R. Development of patient-derived models to study tumor heterogeneity: Studies of colorectal cancer 2019. 215p. ISBN 9789461829436. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Medema J. P.; Co-supervisor: Vermeulen L.)
• Jackstadt Rene, van Hooff Sander R., Leach Joshua D., Cortes-Lavaud Xabier, Lohuis Jeroen O., Ridgway Rachel A., Wouters Valérie M., Roper Jatin, Kendall Timothy J., Roxburgh Campbell S., Horgan Paul G., Nixon Colin, Nourse Craig, Gunzer Matthias, Clark William, Hedley Ann, Yilmaz Omer H., Rashid Mamunur, Bailey Peter, Biankin Andrew V., Campbell Andrew D., Adams David J., Barry Simon T., Steele Colin W., Medema Jan Paul, Sansom Owen J. Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis Cancer cell 2019;36 (3):319-336.e7 [PubMed]
• Ramesh Prashanthi, Kirov Aleksandar Buryanov, Huels David Johannes, Medema Jan Paul Isolation, propagation, and clonogenicity of intestinal stem cellsin: Methods in Molecular Biology. Humana Press Inc.; 2019. p. 61-73
• van der Heijden Maartje, Miedema Daniël M., Waclaw Bartlomiej, Veenstra Veronique L., Lecca Maria C., Nijman Lisanne E., van Dijk Erik, van Neerven Sanne M., Lodestijn Sophie C., Lenos Kristiaan J., de Groot Nina E., Prasetyanti Pramudita R., Varea Andrea Arricibita, Winton Douglas J., Medema Jan Paul, Morrissey Edward, Ylstra Bauke, Nowak Martin A., Bijlsma Maarten F., Vermeulen Louis Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts Proceedings of the National Academy of Sciences of the United States of America 2019;116 (13):6140-6145 [PubMed]
• Ebbing Eva A., van der Zalm Amber P., Steins Anne, Creemers Aafke, Hermsen Simone, Rentenaar Rosa, Klein Michelle, Waasdorp Cynthia, Hooijer Gerrit K. J., Meijer Sybren L., Krishnadath Kausilia K., Punt Cornelis J. A., van Berge Henegouwen Mark I., Gisbertz Suzanne S., van Delden Otto M., Hulshof Maarten C. C. M., Medema Jan Paul, van Laarhoven Hanneke W. M., Bijlsma Maarten F. Stromal-derived interleukin 6 drives epithelial-to-mesenchymal transition and therapy resistance in esophageal adenocarcinoma Proceedings of the National Academy of Sciences of the United States of America 2019;116 (6):2237-2242 [PubMed]

2018

• Veenstra V. L., Damhofer H., Waasdorp C., van Rijssen L. B., van de Vijver M. J., Dijk F., Wilmink H. W., Besselink M. G., Busch O. R., Chang D. K., Bailey P. J., Biankin A. V., Kocher H. M., Medema J. P., Li J. S., Jiang R., Pierce D. W., van Laarhoven H. W. M., Bijlsma M. F. ADAM12 is a circulating marker for stromal activation in pancreatic cancer and predicts response to chemotherapy Oncogenesis 2018;7 (11) [PubMed]
• Medema Jan Paul CANCER Escape from senescence boosts tumour growth Nature 2018;553 (7686):37-38 [PubMed]
• Linnekamp Janneke F., van Hooff Sander R., Prasetyanti Pramudita R., Kandimalla Raju, Buikhuisen Joyce Y., Fessler Evelyn, Ramesh Prashanthi, Lee Kelly A. S. T., Bochove Grehor G. W., de Jong Johan H., Cameron Kate, van Leersum Ronald, Rodermond Hans M., Franitza Marek, Nürnberg Peter, Mangiapane Laura R., Wang Xin, Clevers Hans, Vermeulen Louis, Stassi Giorgio, Medema Jan Paul Consensus molecular subtypes of colorectal cancer are recapitulated in in vitro and in vivo models Cell death and differentiation 2018;25:616-633 [PubMed]
• Mari Luigi, Hoefnagel Sanne J. M., Zito Domenico, van de Meent Marian, van Endert Peter, Calpe Silvia, Sancho Serra Maria del Carmen, Heemskerk Mirjam H. M., van Laarhoven Hanneke W. M., Hulshof Maarten C. C. M., Gisbertz Susanne S., Medema Jan Paul, van Berge Henegouwen Mark I., Meijer Sybren L., Bergman Jacques J. G. H. M., Milano Francesca, Krishnadath Kausilia K. microRNA 125a Regulates MHC-I Expression on Esophageal Adenocarcinoma Cells, Associated With Suppression of Antitumor Immune Response and Poor Outcomes of Patients Gastroenterology 2018;155 (3):784-798 [PubMed]
• Galluzzi Lorenzo, Vitale Ilio, Aaronson Stuart A., Abrams John M., Adam Dieter, Agostinis Patrizia, Alnemri Emad S., Altucci Lucia, Amelio Ivano, Andrews David W., Annicchiarico-Petruzzelli Margherita, Antonov Alexey V., Arama Eli, Baehrecke Eric H., Barlev Nickolai A., Bazan Nicolas G., Bernassola Francesca, Bertrand Mathieu J. M., Bianchi Katiuscia, Blagosklonny Mikhail V., Blomgren Klas, Borner Christoph, Boya Patricia, Brenner Catherine, Campanella Michelangelo, Candi Eleonora, Carmona-Gutierrez Didac, Cecconi Francesco, Chan Francis K.-M., Chandel Navdeep S., Cheng Emily H., Chipuk Jerry E., Cidlowski John A., Ciechanover Aaron, Cohen Gerald M., Conrad Marcus, Cubillos-Ruiz Juan R., Czabotar Peter E., D'Angiolella Vincenzo, Dawson Ted M., Dawson Valina L., de Laurenzi Vincenzo, de Maria Ruggero, Debatin Klaus-Michael, DeBerardinis Ralph J., Deshmukh Mohanish, Di Daniele Nicola, Di Virgilio Francesco, Dixit Vishva M., Dixon Scott J., Duckett Colin S., Dynlacht Brian D., El-Deiry Wafik S., Elrod John W., Fimia Gian Maria, Fulda Simone, García-Sáez Ana J., Garg Abhishek D., Garrido Carmen, Gavathiotis Evripidis, Golstein Pierre, Gottlieb Eyal, Green Douglas R., Greene Lloyd A., Gronemeyer Hinrich, Gross Atan, Hajnoczky Gyorgy, Hardwick J. Marie, Harris Isaac S., Hengartner Michael O., Hetz Claudio, Ichijo Hidenori, Jäättelä Marja, Joseph Bertrand, Jost Philipp J., Juin Philippe P., Kaiser William J., Karin Michael, Kaufmann Thomas, Kepp Oliver, Kimchi Adi, Kitsis Richard N., Klionsky Daniel J., Knight Richard A., Kumar Sharad, Lee Sam W., Lemasters John J., Levine Beth, Linkermann Andreas, Lipton Stuart A., Lockshin Richard A., López-Otín Carlos, Lowe Scott W., Luedde Tom, Lugli Enrico, MacFarlane Marion, Madeo Frank, Malewicz Michal, Malorni Walter, Manic Gwenola, Marine Jean-Christophe, Martin Seamus J., Martinou Jean-Claude, Medema Jan Paul, Mehlen Patrick, Meier Pascal, Melino Sonia, Miao Edward A., Molkentin Jeffery D., Moll Ute M., Muñoz-Pinedo Cristina, Nagata Shigekazu, Nuñez Gabriel, Oberst Andrew, Oren Moshe, Overholtzer Michael, Pagano Michele, Panaretakis Theocharis, Pasparakis Manolis, Penninger Josef M., Pereira David M., Pervaiz Shazib, Peter Marcus E., Piacentini Mauro, Pinton Paolo, Prehn Jochen H. M., Puthalakath Hamsa, Rabinovich Gabriel A., Rehm Markus, Rizzuto Rosario, Rodrigues Cecilia M. P., Rubinsztein David C., Rudel Thomas, Ryan Kevin M., Sayan Emre, Scorrano Luca, Shao Feng, Shi Yufang, Silke John, Simon Hans-Uwe, Sistigu Antonella, Stockwell Brent R., Strasser Andreas, Szabadkai Gyorgy, Tait Stephen W. G., Tang Daolin, Tavernarakis Nektarios, Thorburn Andrew, Tsujimoto Yoshihide, Turk Boris, Vanden Berghe Tom, Vandenabeele Peter, Vander Heiden Matthew G., Villunger Andreas, Virgin Herbert W., Vousden Karen H., Vucic Domagoj, Wagner Erwin F., Walczak Henning, Wallach David, Wang Ying, Wells James A., Wood Will, Yuan Junying, Zakeri Zahra, Zhivotovsky Boris, Zitvogel Laurence, Melino Gerry, Kroemer Guido Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 Cell death and differentiation 2018;25:486-541 [PubMed]
• Veenstra Veronique L. Molecular understanding of Hedgehog-dependent cancers: From pathways to patients 2018. 245p. ISBN 9789463800686. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van Laarhoven H. W. M. , Medema J. P.; Co-supervisor: Bijlsma M. F.)
• Veenstra Veronique L., Dingjan Ilse, Waasdorp Cynthia, Damhofer Helene, van der Wal Allard C., van Laarhoven Hanneke W., Medema Jan Paul, Bijlsma Maarten F. Patched-2 functions to limit Patched-1 deficient skin cancer growth Cellular oncology 2018;41 (4):427-437 [PubMed]
• Fiore Donatella, Ramesh Prashanthi, Proto Maria C., Piscopo Chiara, Franceschelli Silvia, Anzelmo Serena, Medema Jan P., Bifulco Maurizio, Gazzerro Patrizia Rimonabant Kills Colon Cancer Stem Cells without Inducing Toxicity in Normal Colon Organoids Frontiers in pharmacology 2018;8:949 [PubMed]
• Lenos Kristiaan J., Miedema Daniël M., Lodestijn Sophie C., Nijman Lisanne E., van den Bosch Tom, Romero Ros Xavier, Lourenço Filipe C., Lecca Maria C., van der Heijden Maartje, van Neerven Sanne M., van Oort Anita, Leveille Nicolas, Adam Ronja S., de Sousa e Melo Felipe, Otten Joy, Veerman Patrick, Hypolite Guillaume, Koens Lianne, Lyons Scott K., Stassi Giorgio, Winton Douglas J., Medema Jan Paul, Morrissey Edward, Bijlsma Maarten F., Vermeulen Louis Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer Nature cell biology 2018;20 (10):1193-1202 [PubMed]
• Huels David J., Medema Jan Paul Think About the Environment: Cellular Reprogramming by the Extracellular Matrix Cell stem cell 2018;22 (1):7-9 [PubMed]
• Salerno Fiamma, Engels Sander, van den Biggelaar Maartje, van Alphen Floris P. J., Guislain Aurelie, Zhao Wanqi, Hodge Deborah L., Bell Sarah E., Medema Jan Paul, von Lindern Marieke, Turner Martin, Young Howard A., Wolkers Monika C. Translational repression of pre-formed cytokine-encoding mRNA prevents chronic activation of memory T cells Nature immunology 2018;19 (8):828-837 [PubMed]
• Ebbing Eva A. What tumor cells cannot resist: Mechanisms of therapy resistance in esophageal adenocarcinoma 2018. ISBN 9789462958739. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van Laarhoven H. W. M., Medema J. P.; Co-supervisors: Bijlsma M. F., Punt C. J. A.)

2017

• Than B. L. N., Linnekamp J. F., Starr T. K., Largaespada D. A., Rod A., Zhang Y., Bruner V., Abrahante J., Schumann A., Luczak T., Walter J., Niemczyk A., O'Sullivan M. G., Medema J. P., Fijneman R. J. A., Meijer G. A., van den Broek E., Hodges C. A., Scott P. M., Vermeulen L., Cormier R. T. CFTR is a tumor suppressor gene in murine and human intestinal cancer Oncogene 2017;36 (24):3504 [PubMed]
• Linnekamp J. F., Butter R., Spijker R., Medema J. P., van Laarhoven H. W. M. Clinical and biological effects of demethylating agents on solid tumours - A systematic review Cancer treatment reviews 2017;54:10-23 [PubMed]
• Ebbing Eva A., Steins Anne, Fessler Evelyn, Stathi Phylicia, Lesterhuis Willem Joost, Krishnadath Kausilia K., Vermeulen Louis, Medema Jan Paul, Bijlsma Maarten F., van Laarhoven Hanneke W. M. Esophageal Adenocarcinoma Cells and Xenograft Tumors Exposed to Erb-b2 Receptor Tyrosine Kinase 2 and 3 Inhibitors Activate Transforming Growth Factor Beta Signaling, Which Induces Epithelial to Mesenchymal Transition Gastroenterology 2017;153 (1):63-76.e14 [PubMed]
• García-Laorden M. Isabel, Stroo Ingrid, Terpstra Sanne, Florquin Sandrine, Medema Jan Paul, van T Veer Cornelis, de Vos Alex F., van der Poll Tom Expression and Function of Granzymes A and B in Escherichia coli Peritonitis and Sepsis Mediators of inflammation 2017;2017:4137563 [PubMed]
• Prasetyanti Pramudita R., Medema Jan Paul Intra-tumor heterogeneity from a cancer stem cell perspective Molecular cancer 2017;16 (1):41 [PubMed]
• Kandimalla R., Linnekamp J. F., van Hooff S., Castells A., Llor X., Andreu M., Jover R., Goel A., Medema J. P. Methylation of WNT target genes AXIN2 and DKK1 as robust biomarkers for recurrence prediction in stage II colon cancer Oncogenesis 2017;6 (4):e308 [PubMed]
• Trumpi K., Ubink I., Trinh A., Djafarihamedani M., Jongen J. M., Govaert K. M., Elias S. G., van Hooff S. R., Medema J. P., Lacle M. M., Vermeulen L., Borel Rinkes I. H. M., Kranenburg O. Neoadjuvant chemotherapy affects molecular classification of colorectal tumors Oncogenesis 2017;6 (7):e357 [PubMed]
• Trinh Anne, Trumpi Kari, de Sousa E Melo Felipe, Wang Xin, de Jong Joan H., Fessler Evelyn, Kuppen Peter J. K., Reimers Marlies S., Swets Marloes, Koopman Miriam, Nagtegaal Iris D., Jansen Marnix, Hooijer Gerrit K. J., Offerhaus George J. A., Kranenburg Onno, Punt Cornelis J., Medema Jan Paul, Markowetz Florian, Vermeulen Louis Practical and Robust Identification of Molecular Subtypes in Colorectal Cancer by Immunohistochemistry Clinical cancer research 2017;23 (2):387-398 [PubMed]
• van Oorschot Bregje, Uitterhoeve Lon, Oomen Ilja, ten Cate Rosemarie, Medema Jan Paul, Vrieling Harry, Stalpers Lukas J. A., Moerland Perry D., Franken Nicolaas A. P. Prostate Cancer Patients with Late Radiation Toxicity Exhibit Reduced Expression of Genes Involved in DNA Double-Strand Break Repair and Homologous Recombination Cancer research 2017;77 (6):1485-1491 [PubMed]
• Veenstra Veronique L., Damhofer Helene, Waasdorp Cynthia, Steins Anne, Kocher Hemant M., Medema Jan P., van Laarhoven Hanneke W., Bijlsma Maarten F. Stromal SPOCK1 supports invasive pancreatic cancer growth Molecular oncology 2017;11 (8):1050-1064 [PubMed]
• Steins Anne, Ebbing Eva A., Pistorius Marcel C. M., Waasdorp Cynthia, Krishnadath Kausilia K., Medema Jan Paul, Wilmink Johanna W., Mathôt Ron A. A., Bijlsma Maarten F., van Laarhoven Hanneke W. M. Systemic effects of angiogenesis inhibition alter pharmacokinetics and intratumoral delivery of nab-paclitaxel Drug delivery 2017;24 (1):1801-1810 [PubMed]
• Medema Jan Paul Targeting the Colorectal Cancer Stem Cell New England journal of medicine 2017;377 (9):888-890 [PubMed]
• Oei Arlene L. Tumor cells can’t stand the heat: Boosting the effectiveness of hyperthermia in cervical carcinoma 2017. 299p. ISBN 9789462955103. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Medema J. P., Stalpers L. J. A.; Co-supervisors: Franken N. A. P., Kok H. P.)

2016

• Ebbing Eva A., Medema Jan Paul, Damhofer Helene, Meijer Sybren L., Krishnadath Kausilia K., van Berge Henegouwen Mark I., Bijlsma Maarten F., van Laarhoven Hanneke W. M. ADAM10-mediated release of heregulin confers resistance to trastuzumab by activating HER3 Oncotarget 2016;7 (9):10243-10254 [PubMed]
• Fessler E., Jansen M., de Sousa E Melo F., Zhao L., Prasetyanti P. R., Rodermond H., Kandimalla R., Linnekamp J. F., Franitza M., van Hooff S. R., de Jong J. H., Oppeneer S. C., van Noesel C. J. M., Dekker E., Stassi G., Wang X., Medema J. P., Vermeulen L. A multidimensional network approach reveals microRNAs as determinants of the mesenchymal colorectal cancer subtype Oncogene 2016;35 (46):6026-6037 [PubMed]
• van der Heijden Maartje, Zimberlin Cheryl D., Nicholson Anna M., Colak Selcuk, Kemp Richard, Meijer Sybren L., Medema Jan Paul, Greten Florian R., Jansen Marnix, Winton Douglas J., Vermeulen Louis Bcl-2 is a critical mediator of intestinal transformation Nature communications 2016;7:10916 [PubMed]
• Potze L., Di Franco S., Grandela C., Pras-Raves M. L., Picavet D. I., van Veen H. A., van Lenthe H., Mullauer F. B., van der Wel N. N., Luyf A., van Kampen A. H. C., Kemp S., Everts V., Kessler J. H., Vaz F. M., Medema J. P. Betulinic acid induces a novel cell death pathway that depends on cardiolipin modification Oncogene 2016;35 (4):427-437 [PubMed]
• Potze Lisette, Di Franco Simone, Kessler Jan H., Stassi Giorgio, Medema Jan Paul Betulinic Acid Kills Colon Cancer Stem Cells Current stem cell research & therapy 2016;11 (5):427-433 [PubMed]
• Than B. L. N., Linnekamp J. F., Starr T. K., Largaespada D. A., Rod A., Zhang Y., Bruner V., Abrahante J., Schumann A., Luczak T., Niemczyk A., O'Sullivan M. G., Medema J. P., Fijneman R. J. A., Meijer G. A., van den Broek E., Hodges C. A., Scott P. M., Vermeulen L., Cormier R. T. CFTR is a tumor suppressor gene in murine and human intestinal cancer Oncogene 2016;35 (32):4179-4187 [PubMed]
• Vellinga T. T., den Uil S., Rinkes I. H. B., Marvin D., Ponsioen B., Alvarez-Varela A., Fatrai S., Scheele C., Zwijnenburg D. A., Snippert H., Vermeulen L., Medema J. P., Stockmann H. B., Koster J., Fijneman R. J. A., de Rooij J., Kranenburg O. Collagen-rich stroma in aggressive colon tumors induces mesenchymal gene expression and tumor cell invasion Oncogene 2016;35 (40):5263-5271 [PubMed]
• Fessler Evelyn, Medema Jan Paul Colorectal Cancer Subtypes: Developmental Origin and Microenvironmental Regulation Trends in cancer 2016;2 (9):505-518 [PubMed]
• Zimberlin Cheryl D. Crossing Borders: Manipulating stemness through carcinogenesis 2016. 221p. ISBN 9789461826763. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Medema J. P.; Co-supervisors: Vermeulen L., Bots M.)
• Lam Kevin, Pan Kathy, Linnekamp Janneke Fiona, Medema Jan Paul, Kandimalla Raju DNA methylation based biomarkers in colorectal cancer: A systematic review BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS 2016;1866 (1):106-120 [PubMed]
• Fessler Evelyn Exploring tumor heterogeneity 2016. 196p. ISBN 9789462953796. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Medema J. P.; Co-supervisor: Vermeulen L.)
• van den Boogaard Florry E., van Gisbergen Klaas P. J. M., Vernooy Juanita H., Medema Jan P., Roelofs Joris J. T. H., van Zoelen Marieke A. D., Endeman Henrik, Biesma Douwe H., Boon Louis, van't Veer Cornelis, de Vos Alex F., van der Poll Tom Granzyme A impairs host defense during Streptococcus pneumoniae pneumonia American journal of physiology. Lung cellular and molecular physiology 2016;311 (2):L507-L516 [PubMed]
• García-Laorden M. Isabel, Stroo Ingrid, Blok Dana C., Florquin Sandrine, Medema Jan Paul, de Vos Alex F., van der Poll Tom Granzymes A and B Regulate the Local Inflammatory Response during Klebsiella pneumoniae Pneumonia Journal of innate immunity 2016;8 (3):258-268 [PubMed]
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Robin, Higaki Katsumi, Hilfiker Sabine, Hill Bradford G., Hill Joseph A., Hill William D., Hino Keisuke, Hofius Daniel, Hofman Paul, Höglinger Günter U., Höhfeld Jörg, Holz Marina K., Hong Yonggeun, Hood David A., Hoozemans Jeroen Jm, Hoppe Thorsten, Hsu Chin, Hsu Chin-Yuan, Hsu Li-Chung, Hu Dong, Hu Guochang, Hu Hong-Ming, Hu Hongbo, Hu Ming Chang, Hu Yu-Chen, Hu Zhuo-Wei, Hua Fang, Hua Ya, Huang Canhua, Huang Huey-Lan, Huang Kuo-How, Huang Kuo-Yang, Huang Shile, Huang Shiqian, Huang Wei-Pang, Huang Yi-Ran, Huang Yong, Huang Yunfei, Huber Tobias B., Huebbe Patricia, Huh Won-Ki, Hulmi Juha J., Hur Gang Min, Hurley James H., Husak Zvenyslava, Hussain Sabah Na, Hussain Salik, Hwang Jung Jin, Hwang Seungmin, Hwang Thomas Is, Ichihara Atsuhiro, Imai Yuzuru, Imbriano Carol, Inomata Megumi, Into Takeshi, Iovane Valentina, Iovanna Juan L., Iozzo Renato V., Ip Nancy Y., Irazoqui Javier E., Iribarren Pablo, Isaka Yoshitaka, Isakovic Aleksandra J., Ischiropoulos Harry, Isenberg Jeffrey S., Ishaq Mohammad, Ishida Hiroyuki, Ishii Isao, Ishmael Jane E., Isidoro Ciro, Isobe Ken-ichi, Isono Erika, Issazadeh-Navikas Shohreh, Itahana Koji, Itakura Eisuke, Ivanov Andrei I., Iyer Anand Krishnan V., Izquierdo José M., Izumi Yotaro, Izzo Valentina, Jäättelä Marja, Jaber Nadia, Jackson Daniel John, Jackson William T., Jacob Tony George, Jacques Thomas S., Jagannath Chinnaswamy, Jain Ashish, Jana Nihar Ranjan, Jang Byoung Kuk, Jani Alkesh, Janji Bassam, Jannig Paulo Roberto, Jansson Patric J., Jean Steve, Jendrach Marina, Jeon Ju-Hong, Jessen Niels, Jeung Eui-Bae, Jia Kailiang, Jia Lijun, Jiang Hong, Jiang Hongchi, Jiang Liwen, Jiang Teng, Jiang Xiaoyan, Jiang Xuejun, Jiang Ying, Jiang Yongjun, Jiménez Alberto, Jin Cheng, Jin Hongchuan, Jin Lei, Jin Meiyan, Jin Shengkan, Jinwal Umesh Kumar, Jo Eun-Kyeong, Johansen Terje, Johnson Daniel E., Johnson Gail Vw, Johnson James D., Jonasch Eric, Jones Chris, Joosten Leo Ab, Jordan Joaquin, Joseph Anna-Maria, Joseph Bertrand, Joubert Annie M., Ju Dianwen, Ju Jingfang, Juan Hsueh-Fen, Juenemann Katrin, Juhász Gábor, Jung Hye Seung, Jung Jae U., Jung Yong-Keun, Jungbluth Heinz, Justice Matthew J., Jutten Barry, Kaakoush Nadeem O., Kaarniranta Kai, Kaasik Allen, Kabuta Tomohiro, Kaeffer Bertrand, Kågedal Katarina, Kahana Alon, Kajimura Shingo, Kakhlon Or, Kalia Manjula, Kalvakolanu Dhan V., Kamada Yoshiaki, Kambas Konstantinos, Kaminskyy Vitaliy O., Kampinga Harm H., Kandouz Mustapha, Kang Chanhee, Kang Rui, Kang Tae-Cheon, Kanki Tomotake, Kanneganti Thirumala-Devi, Kanno Haruo, Kanthasamy Anumantha G., Kantorow Marc, Kaparakis-Liaskos Maria, Kapuy Orsolya, Karantza Vassiliki, Karim Md Razaul, Karmakar Parimal, Kaser Arthur, Kaushik Susmita, Kawula Thomas, Kaynar A. Murat, Ke Po-Yuan, Ke Zun-Ji, Kehrl John H., Keller Kate E., Kemper Jongsook Kim, Kenworthy Anne K., Kepp Oliver, Kern Andreas, Kesari Santosh, Kessel David, Ketteler Robin, Kettelhut Isis do Carmo, Khambu Bilon, Khan Muzamil Majid, Khandelwal Vinoth Km, Khare Sangeeta, Kiang Juliann G., Kiger Amy A., Kihara Akio, Kim Arianna L., Kim Cheol Hyeon, Kim Deok Ryong, Kim Do-Hyung, Kim Eung Kweon, Kim Hye Young, Kim Hyung-Ryong, Kim Jae-Sung, Kim Jeong Hun, Kim Jin Cheon, Kim Jin Hyoung, Kim Kwang Woon, Kim Michael D., Kim Moon-Moo, Kim Peter K., Kim Seong Who, Kim Soo-Youl, Kim Yong-Sun, Kim Yonghyun, Kimchi Adi, Kimmelman Alec C., Kimura Tomonori, King Jason S., Kirkegaard Karla, Kirkin Vladimir, Kirshenbaum Lorrie A., Kishi Shuji, Kitajima Yasuo, Kitamoto Katsuhiko, Kitaoka Yasushi, Kitazato Kaio, Kley Rudolf A., Klimecki Walter T., Klinkenberg Michael, Klucken Jochen, Knævelsrud Helene, Knecht Erwin, Knuppertz Laura, Ko Jiunn-Liang, Kobayashi Satoru, Koch Jan C., Koechlin-Ramonatxo Christelle, Koenig Ulrich, Koh Young Ho, Köhler Katja, Kohlwein Sepp D., Koike Masato, Komatsu Masaaki, Kominami Eiki, Kong Dexin, Kong Hee Jeong, Konstantakou Eumorphia G., Kopp Benjamin T., Korcsmaros Tamas, Korhonen Laura, Korolchuk Viktor I., Koshkina Nadya V., Kou Yanjun, Koukourakis Michael I., Koumenis Constantinos, Kovács Attila L., Kovács Tibor, Kovacs Werner J., Koya Daisuke, Kraft Claudine, Krainc Dimitri, Kramer Helmut, Kravic-Stevovic Tamara, Krek Wilhelm, Kretz-Remy Carole, Krick Roswitha, Krishnamurthy Malathi, Kriston-Vizi Janos, Kroemer Guido, Kruer Michael C., Kruger Rejko, Ktistakis Nicholas T., Kuchitsu Kazuyuki, Kuhn Christian, Kumar Addanki Pratap, Kumar Anuj, Kumar Ashok, Kumar Deepak, Kumar Dhiraj, Kumar Rakesh, Kumar Sharad, Kundu Mondira, Kung Hsing-Jien, Kuno Atsushi, Kuo Sheng-Han, Kuret Jeff, Kurz Tino, Kwok Terry, Kwon Taeg Kyu, Kwon Yong Tae, Kyrmizi Irene, La Spada Albert R., Lafont Frank, Lahm Tim, Lakkaraju Aparna, Lam Truong, Lamark Trond, Lancel Steve, Landowski Terry H., Lane Darius J. R., Lane Jon D., Lanzi Cinzia, Lapaquette Pierre, Lapierre Louis R., Laporte Jocelyn, Laukkarinen Johanna, Laurie Gordon W., Lavandero Sergio, Lavie Lena, LaVoie Matthew J., Law Betty Yuen Kwan, Law Helen Ka-Wai, Law Kelsey B., Layfield Robert, Lazo Pedro A., Le Cam Laurent, Le Roch Karine G., Le Stunff Hervé, Leardkamolkarn Vijittra, Lecuit Marc, Lee Byung-Hoon, Lee Che-Hsin, Lee Erinna F., Lee Gyun Min, Lee He-Jin, Lee Hsinyu, Lee Jae Keun, Lee Jongdae, Lee Ju-Hyun, Lee Jun Hee, Lee Michael, Lee Myung-Shik, Lee Patty J., Lee Sam W., Lee Seung-Jae, Lee Shiow-Ju, Lee Stella Y., Lee Sug Hyung, Lee Sung Sik, Lee Sung-Joon, Lee Sunhee, Lee Ying-Ray, Lee Yong J., Lee Young H., Leeuwenburgh Christiaan, Lefort Sylvain, Legouis Renaud, Lei Jinzhi, Lei Qun-Ying, Leib David A., Leibowitz Gil, Lekli Istvan, Lemaire Stéphane D., Lemasters John J., Lemberg Marius K., Lemoine Antoinette, Leng Shuilong, Lenz Guido, Lenzi Paola, Lerman Lilach O., Lettieri Barbato Daniele, Leu Julia I.-Ju, Leung Hing Y., Levine Beth, Lewis Patrick A., Lezoualc'h Frank, Li Chi, Li Faqiang, Li Feng-Jun, Li Jun, Li Ke, Li Lian, Li Min, Li Qiang, Li Rui, Li Sheng, Li Wei, Li Xiaotao, Li Yumin, Lian Jiqin, Liang Chengyu, Liang Qiangrong, Liao Yulin, Liberal Joana, Liberski Pawel P., Lie Pearl, Lieberman Andrew P., Lim Hyunjung Jade, Lim Kah-Leong, Lim Kyu, Lima Raquel T., Lin Chang-Shen, Lin Chiou-Feng, Lin Fang, Lin Fangming, Lin Fu-Cheng, Lin Kui, Lin Kwang-Huei, Lin Pei-Hui, Lin Tianwei, Lin Wan-Wan, Lin Yee-Shin, Lin Yong, Linden Rafael, Lindholm Dan, Lindqvist Lisa M., Lingor Paul, Linkermann Andreas, Liotta Lance A., Lipinski Marta M., Lira Vitor A., Lisanti Michael P., Liton Paloma B., Liu Bo, Liu Chong, Liu Chun-Feng, Liu Fei, Liu Hung-Jen, Liu Jianxun, Liu Jing-Jing, Liu Jing-Lan, Liu Ke, Liu Leyuan, Liu Liang, Liu Quentin, Liu Rong-Yu, Liu Shiming, Liu Shuwen, Liu Wei, Liu Xian-De, Liu Xiangguo, Liu Xiao-Hong, Liu Xinfeng, Liu Xu, Liu Xueqin, Liu Yang, Liu Yule, Liu Zexian, Liu Zhe, Liuzzi Juan P., Lizard Gérard, Ljujic Mila, Lodhi Irfan J., Logue Susan E., Lokeshwar Bal L., Long Yun Chau, Lonial Sagar, Loos Benjamin, López-Otín Carlos, López-Vicario Cristina, Lorente Mar, Lorenzi Philip L., Lõrincz Péter, Los Marek, Lotze Michael T., Lovat Penny E., Lu Binfeng, Lu Bo, Lu Jiahong, Lu Qing, Lu She-Min, Lu Shuyan, Lu Yingying, Luciano Frédéric, Luckhart Shirley, Lucocq John Milton, Ludovico Paula, Lugea Aurelia, Lukacs Nicholas W., Lum Julian J., Lund Anders H., Luo Honglin, Luo Jia, Luo Shouqing, Luparello Claudio, Lyons Timothy, Ma Jianjie, Ma Yi, Ma Yong, Ma Zhenyi, Machado Juliano, Machado-Santelli Glaucia M., Macian Fernando, MacIntosh Gustavo C., MacKeigan Jeffrey P., Macleod Kay F., MacMicking John D., MacMillan-Crow Lee Ann, Madeo Frank, Madesh Muniswamy, Madrigal-Matute Julio, Maeda Akiko, Maeda Tatsuya, Maegawa Gustavo, Maellaro Emilia, Maes Hannelore, Magariños Marta, Maiese Kenneth, Maiti Tapas K., Maiuri Luigi, Maiuri Maria Chiara, Maki Carl G., Malli Roland, Malorni Walter, Maloyan Alina, Mami-Chouaib Fathia, Man Na, Mancias Joseph D., Mandelkow Eva-Maria, Mandell Michael A., Manfredi Angelo A., Manié Serge N., Manzoni Claudia, Mao Kai, Mao Zixu, Mao Zong-Wan, Marambaud Philippe, Marconi Anna Maria, Marelja Zvonimir, Marfe Gabriella, Margeta Marta, Margittai Eva, Mari Muriel, Mariani Francesca V., Marin Concepcio, Marinelli Sara, Mariño Guillermo, Markovic Ivanka, Marquez Rebecca, Martelli Alberto M., Martens Sascha, Martin Katie R., Martin Seamus J., Martin Shaun, Martin-Acebes Miguel A., Martín-Sanz Paloma, Martinand-Mari Camille, Martinet Wim, Martinez Jennifer, Martinez-Lopez Nuria, Martinez-Outschoorn Ubaldo, Martínez-Velázquez Moisés, Martinez-Vicente Marta, Martins Waleska Kerllen, Mashima Hirosato, Mastrianni James A., Matarese Giuseppe, Matarrese Paola, Mateo Roberto, Matoba Satoaki, Matsumoto Naomichi, Matsushita Takehiko, Matsuura Akira, Matsuzawa Takeshi, Mattson Mark P., Matus Soledad, Maugeri Norma, Mauvezin Caroline, Mayer Andreas, Maysinger Dusica, Mazzolini Guillermo D., McBrayer Mary Kate, McCall Kimberly, McCormick Craig, McInerney Gerald M., McIver Skye C., McKenna Sharon, McMahon John J., McNeish Iain A., Mechta-Grigoriou Fatima, Medema Jan Paul, Medina Diego L., Megyeri Klara, Mehrpour Maryam, Mehta Jawahar L., Mei Yide, Meier Ute-Christiane, Meijer Alfred J., Meléndez Alicia, Melino Gerry, Melino Sonia, de Melo Edesio Jose Tenorio, Mena Maria A., Meneghini Marc D., Menendez Javier A., Menezes Regina, Meng Liesu, Meng Ling-Hua, Meng Songshu, Menghini Rossella, Menko A. 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Javier, Ollinger Karin, Olsson Stefan, Orban Daniel P., Ordonez Paulina, Orhon Idil, Orosz Laszlo, O'Rourke Eyleen J., Orozco Helena, Ortega Angel L., Ortona Elena, Osellame Laura D., Oshima Junko, Oshima Shigeru, Osiewacz Heinz D., Otomo Takanobu, Otsu Kinya, Ou Jing-hsiung James, Outeiro Tiago F., Ouyang Dong-Yun, Ouyang Hongjiao, Overholtzer Michael, Ozbun Michelle A., Ozdinler P. 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Ashutosh, Rasmussen Blake B., Rasse Tobias M., Ratovitski Edward A., Rautou Pierre-Emmanuel, Ray Swapan K., Razani Babak, Reed Bruce H., Reggiori Fulvio, Rehm Markus, Reichert Andreas S., Rein Theo, Reiner David J., Reits Eric, Ren Jun, Ren Xingcong, Renna Maurizio, Reusch Jane Eb, Revuelta Jose L., Reyes Leticia, Rezaie Alireza R., Richards Robert I., Richardson Des R., Richetta Clémence, Riehle Michael A., Rihn Bertrand H., Rikihisa Yasuko, Riley Brigit E., Rimbach Gerald, Rippo Maria Rita, Ritis Konstantinos, Rizzi Federica, Rizzo Elizete, Roach Peter J., Robbins Jeffrey, Roberge Michel, Roca Gabriela, Roccheri Maria Carmela, Rocha Sonia, Rodrigues Cecilia Mp, Rodríguez Clara I., de Cordoba Santiago Rodriguez, Rodriguez-Muela Natalia, Roelofs Jeroen, Rogov Vladimir V., Rohn Troy T., Rohrer Bärbel, Romanelli Davide, Romani Luigina, Romano Patricia Silvia, Roncero M. Isabel G., Rosa Jose Luis, Rosello Alicia, Rosen Kirill V., Rosenstiel Philip, Rost-Roszkowska Magdalena, Roth Kevin A., Roué Gael, Rouis Mustapha, Rouschop Kasper M., Ruan Daniel T., Ruano Diego, Rubinsztein David C., Rucker Edmund B., Rudich Assaf, Rudolf Emil, Rudolf Ruediger, Ruegg Markus A., Ruiz-Roldan Carmen, Ruparelia Avnika Ashok, Rusmini Paola, Russ David W., Russo Gian Luigi, Russo Giuseppe, Russo Rossella, Rusten Tor Erik, Ryabovol Victoria, Ryan Kevin M., Ryter Stefan W., Sabatini David M., Sacher Michael, Sachse Carsten, Sack Michael N., Sadoshima Junichi, Saftig Paul, Sagi-Eisenberg Ronit, Sahni Sumit, Saikumar Pothana, Saito Tsunenori, Saitoh Tatsuya, Sakakura Koichi, Sakoh-Nakatogawa Machiko, Sakuraba Yasuhito, Salazar-Roa María, Salomoni Paolo, Saluja Ashok K., Salvaterra Paul M., Salvioli Rosa, Samali Afshin, Sanchez Anthony Mj, Sánchez-Alcázar José A., Sanchez-Prieto Ricardo, Sandri Marco, Sanjuan Miguel A., Santaguida Stefano, Santambrogio Laura, Santoni Giorgio, Dos Santos Claudia Nunes, Saran Shweta, Sardiello Marco, Sargent Graeme, Sarkar Pallabi, Sarkar Sovan, Sarrias Maria Rosa, Sarwal Minnie M., Sasakawa Chihiro, Sasaki Motoko, Sass Miklos, Sato Ken, Sato Miyuki, Satriano Joseph, Savaraj Niramol, Saveljeva Svetlana, Schaefer Liliana, Schaible Ulrich E., Scharl Michael, Schatzl Hermann M., Schekman Randy, Scheper Wiep, Schiavi Alfonso, Schipper Hyman M., Schmeisser Hana, Schmidt Jens, Schmitz Ingo, Schneider Bianca E., Schneider E. 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James, Shen Chiung-Chyi, Shen Han-Ming, Shen Sanbing, Shen Weili, Sheng Rui, Sheng Xianyong, Sheng Zu-Hang, Shepherd Trevor G., Shi Junyan, Shi Qiang, Shi Qinghua, Shi Yuguang, Shibutani Shusaku, Shibuya Kenichi, Shidoji Yoshihiro, Shieh Jeng-Jer, Shih Chwen-Ming, Shimada Yohta, Shimizu Shigeomi, Shin Dong Wook, Shinohara Mari L., Shintani Michiko, Shintani Takahiro, Shioi Tetsuo, Shirabe Ken, Shiri-Sverdlov Ronit, Shirihai Orian, Shore Gordon C., Shu Chih-Wen, Shukla Deepak, Sibirny Andriy A., Sica Valentina, Sigurdson Christina J., Sigurdsson Einar M., Sijwali Puran Singh, Sikorska Beata, Silveira Wilian A., Silvente-Poirot Sandrine, Silverman Gary A., Simak Jan, Simmet Thomas, Simon Anna Katharina, Simon Hans-Uwe, Simone Cristiano, Simons Matias, Simonsen Anne, Singh Rajat, Singh Shivendra V., Singh Shrawan K., Sinha Debasish, Sinha Sangita, Sinicrope Frank A., Sirko Agnieszka, Sirohi Kapil, Sishi Balindiwe Jn, Sittler Annie, Siu Parco M., Sivridis Efthimios, Skwarska Anna, Slack Ruth, Slaninová Iva, Slavov Nikolai, Smaili Soraya S., Smalley Keiran Sm, Smith Duncan R., Soenen Stefaan J., Soleimanpour Scott A., Solhaug Anita, Somasundaram Kumaravel, Son Jin H., Sonawane Avinash, Song Chunjuan, Song Fuyong, Song Hyun Kyu, Song Ju-Xian, Song Wei, Soo Kai Y., Sood Anil K., Soong Tuck Wah, Soontornniyomkij Virawudh, Sorice Maurizio, Sotgia Federica, Soto-Pantoja David R., Sotthibundhu Areechun, Sousa Maria João, Spaink Herman P., Span Paul N., Spang Anne, Sparks Janet D., Speck Peter G., Spector Stephen A., Spies Claudia D., Springer Wolfdieter, Clair Daret St, Stacchiotti Alessandra, Staels Bart, Stang Michael T., Starczynowski Daniel T., Starokadomskyy Petro, Steegborn Clemens, Steele John W., Stefanis Leonidas, Steffan Joan, Stellrecht Christine M., Stenmark Harald, Stepkowski Tomasz M., Stern Stęphan T., Stevens Craig, Stockwell Brent R., Stoka Veronika, Storchova Zuzana, Stork Björn, Stratoulias Vassilis, Stravopodis Dimitrios J., Strnad Pavel, Strohecker Anne Marie, Ström Anna-Lena, Stromhaug Per, Stulik Jiri, Su Yu-Xiong, Su Zhaoliang, Subauste Carlos S., Subramaniam Srinivasa, Sue Carolyn M., Suh Sang Won, Sui Xinbing, Sukseree Supawadee, Sulzer David, Sun Fang-Lin, Sun Jiaren, Sun Jun, Sun Shi-Yong, Sun Yang, Sun Yi, Sun Yingjie, Sundaramoorthy Vinod, Sung Joseph, Suzuki Hidekazu, Suzuki Kuninori, Suzuki Naoki, Suzuki Tadashi, Suzuki Yuichiro J., Swanson Michele S., Swanton Charles, Swärd Karl, Swarup Ghanshyam, Sweeney Sean T., Sylvester Paul W., Szatmari Zsuzsanna, Szegezdi Eva, Szlosarek Peter W., Taegtmeyer Heinrich, Tafani Marco, Taillebourg Emmanuel, Tait Stephen Wg, Takacs-Vellai Krisztina, Takahashi Yoshinori, Takáts Szabolcs, Takemura Genzou, Takigawa Nagio, Talbot Nicholas J., Tamagno Elena, Tamburini Jerome, Tan Cai-Ping, Tan Lan, Tan Mei Lan, Tan Ming, Tan Yee-Joo, Tanaka Keiji, Tanaka Masaki, Tang Daolin, Tang Dingzhong, Tang Guomei, Tanida Isei, Tanji Kunikazu, Tannous Bakhos A., Tapia Jose A., Tasset-Cuevas Inmaculada, Tatar Marc, Tavassoly Iman, Tavernarakis Nektarios, Taylor Allen, Taylor Graham S., Taylor Gregory A., Taylor J. Paul, Taylor Mark J., Tchetina Elena V., tee Andrew R., Teixeira-Clerc Fatima, Telang Sucheta, Tencomnao Tewin, Teng Ba-Bie, Teng Ru-Jeng, Terro Faraj, Tettamanti Gianluca, Theiss Arianne L., Theron Anne E., Thomas Kelly Jean, Thomé Marcos P., Thomes Paul G., Thorburn Andrew, Thorner Jeremy, Thum Thomas, Thumm Michael, Thurston Teresa Lm, Tian Ling, Till Andreas, Ting Jenny Pan-Yun, Titorenko Vladimir I., Toker Lilach, Toldo Stefano, Tooze Sharon A., Topisirovic Ivan, Torgersen Maria Lyngaas, Torosantucci Liliana, Torriglia Alicia, Torrisi Maria Rosaria, Tournier Cathy, Towns Roberto, Trajkovic Vladimir, Travassos Leonardo H., Triola Gemma, Tripathi Durga Nand, Trisciuoglio Daniela, Troncoso Rodrigo, Trougakos Ioannis P., Truttmann Anita C., Tsai Kuen-Jer, Tschan Mario P., Tseng Yi-Hsin, Tsukuba Takayuki, Tsung Allan, Tsvetkov Andrey S., Tu Shuiping, Tuan Hsing-Yu, Tucci Marco, Tumbarello David A., Turk Boris, Turk Vito, Turner Robin Fb, Tveita Anders A., Tyagi Suresh C., Ubukata Makoto, Uchiyama Yasuo, Udelnow Andrej, Ueno Takashi, Umekawa Midori, Umemiya-Shirafuji Rika, Underwood Benjamin R., Ungermann Christian, Ureshino Rodrigo P., Ushioda Ryo, Uversky Vladimir N., Uzcátegui Néstor L., Vaccari Thomas, Vaccaro Maria I., Váchová Libuše, Vakifahmetoglu-Norberg Helin, Valdor Rut, Valente Enza Maria, Vallette Francois, Valverde Angela M., van den Berghe Greet, van den Bosch Ludo, van den Brink Gijs R., van der Goot F. Gisou, van der Klei Ida J., van der Laan Luc Jw, van Doorn Wouter G., van Egmond Marjolein, van Golen Kenneth L., van Kaer Luc, van Lookeren Campagne Menno, Vandenabeele Peter, Vandenberghe Wim, Vanhorebeek Ilse, Varela-Nieto Isabel, Vasconcelos M. Helena, Vasko Radovan, Vavvas Demetrios G., Vega-Naredo Ignacio, Velasco Guillermo, Velentzas Athanassios D., Velentzas Panagiotis D., Vellai Tibor, Vellenga Edo, Vendelbo Mikkel Holm, Venkatachalam Kartik, Ventura Natascia, Ventura Salvador, Veras Patrícia St, Verdier Mireille, Vertessy Beata G., Viale Andrea, Vidal Michel, Vieira Helena L. A., Vierstra Richard D., Vigneswaran Nadarajah, Vij Neeraj, Vila Miquel, Villar Margarita, Villar Victor H., Villarroya Joan, Vindis Cécile, Viola Giampietro, Viscomi Maria Teresa, Vitale Giovanni, Vogl Dan T., Voitsekhovskaja Olga V., von Haefen Clarissa, von Schwarzenberg Karin, Voth Daniel E., Vouret-Craviari Valérie, Vuori Kristina, Vyas Jatin M., Waeber Christian, Walker Cheryl Lyn, Walker Mark J., Walter Jochen, Wan Lei, Wan Xiangbo, Wang Bo, Wang Caihong, Wang Chao-Yung, Wang Chengshu, Wang Chenran, Wang Chuangui, Wang Dong, Wang Fen, Wang Fuxin, Wang Guanghui, Wang Hai-Jie, Wang Haichao, Wang Hong-Gang, Wang Hongmin, Wang Horng-Dar, Wang Jing, Wang Junjun, Wang Mei, Wang Mei-Qing, Wang Pei-Yu, Wang Peng, Wang Richard C., Wang Shuo, Wang Ting-Fang, Wang Xian, Wang Xiao-Jia, Wang Xiao-Wei, Wang Xin, Wang Xuejun, Wang Yan, Wang Yanming, Wang Ying, Wang Ying-Jan, Wang Yipeng, Wang Yu, Wang Yu Tian, Wang Yuqing, Wang Zhi-Nong, Wappner Pablo, Ward Carl, Ward Diane McVey, Warnes Gary, Watada Hirotaka, Watanabe Yoshihisa, Watase Kei, Weaver Timothy E., Weekes Colin D., Wei Jiwu, Weide Thomas, Weihl Conrad C., Weindl Günther, Weis Simone Nardin, Wen Longping, Wen Xin, Wen Yunfei, Westermann Benedikt, Weyand Cornelia M., White Anthony R., White Eileen, Whitton J. Lindsay, Whitworth Alexander J., Wiels Joëlle, Wild Franziska, Wildenberg Manon E., Wileman Tom, Wilkinson Deepti Srinivas, Wilkinson Simon, Willbold Dieter, Williams Chris, Williams Katherine, Williamson Peter R., Winklhofer Konstanze F., Witkin Steven S., Wohlgemuth Stephanie E., Wollert Thomas, Wolvetang Ernst J., Wong Esther, Wong G. William, Wong Richard W., Wong Vincent Kam Wai, Woodcock Elizabeth A., Wright Karen L., Wu Chunlai, Wu Defeng, Wu Gen Sheng, Wu Jian, Wu Junfang, Wu Mian, Wu Min, Wu Shengzhou, Wu William Kk, Wu Yaohua, Wu Zhenlong, Xavier Cristina Pr, Xavier Ramnik J., Xia Gui-Xian, Xia Tian, Xia Weiliang, Xia Yong, Xiao Hengyi, Xiao Jian, Xiao Shi, Xiao Wuhan, Xie Chuan-Ming, Xie Zhiping, Xie Zhonglin, Xilouri Maria, Xiong Yuyan, Xu Chuanshan, Xu Congfeng, Xu Feng, Xu Haoxing, Xu Hongwei, Xu Jian, Xu Jianzhen, Xu Jinxian, Xu Liang, Xu Xiaolei, Xu Yangqing, Xu Ye, Xu Zhi-Xiang, Xu Ziheng, Xue Yu, Yamada Takahiro, Yamamoto Ai, Yamanaka Koji, Yamashina Shunhei, Yamashiro Shigeko, Yan Bing, Yan Bo, Yan Xianghua, Yan Zhen, Yanagi Yasuo, Yang Dun-Sheng, Yang Jin-Ming, Yang Liu, Yang Minghua, Yang Pei-Ming, Yang Peixin, Yang Qian, Yang Wannian, Yang Wei Yuan, Yang Xuesong, Yang Yi, Yang Ying, Yang Zhifen, Yang Zhihong, Yao Meng-Chao, Yao Pamela J., Yao Xiaofeng, Yao Zhenyu, Yao Zhiyuan, Yasui Linda S., Ye Mingxiang, Yedvobnick Barry, Yeganeh Behzad, Yeh Elizabeth S., Yeyati Patricia L., Yi Fan, Yi Long, Yin Xiao-Ming, Yip Calvin K., Yoo Yeong-Min, Yoo Young Hyun, Yoon Seung-Yong, Yoshida Ken-Ichi, Yoshimori Tamotsu, Young Ken H., Yu Huixin, Yu Jane J., Yu Jin-Tai, Yu Jun, Yu Li, Yu W. Haung, Yu Xiao-Fang, Yu Zhengping, Yuan Junying, Yuan Zhi-Min, Yue Beatrice Yjt, Yue Jianbo, Yue Zhenyu, Zacks David N., Zacksenhaus Eldad, Zaffaroni Nadia, Zaglia Tania, Zakeri Zahra, Zecchini Vincent, Zeng Jinsheng, Zeng Min, Zeng Qi, Zervos Antonis S., Zhang Donna D., Zhang Fan, Zhang Guo, Zhang Guo-Chang, Zhang Hao, Zhang Hong, Zhang Hongbing, Zhang Jian, Zhang Jiangwei, Zhang Jianhua, Zhang Jing-Pu, Zhang Li, Zhang Lin, Zhang Long, Zhang Ming-Yong, Zhang Xiangnan, Zhang Xu Dong, Zhang Yan, Zhang Yang, Zhang Yanjin, Zhang Yingmei, Zhang Yunjiao, Zhao Mei, Zhao Wei-Li, Zhao Xiaonan, Zhao Yan G., Zhao Ying, Zhao Yongchao, Zhao Yu-Xia, Zhao Zhendong, Zhao Zhizhuang J., Zheng Dexian, Zheng Xi-Long, Zheng Xiaoxiang, Zhivotovsky Boris, Zhong Qing, Zhou Guang-Zhou, Zhou Guofei, Zhou Huiping, Zhou Shu-Feng, Zhou Xu-Jie, Zhu Hongxin, Zhu Hua, Zhu Wei-Guo, Zhu Wenhua, Zhu Xiao-Feng, Zhu Yuhua, Zhuang Shi-Mei, Zhuang Xiaohong, Ziparo Elio, Zois Christos E., Zoladek Teresa, Zong Wei-Xing, Zorzano Antonio, Zughaier Susu M. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) Autophagy 2016;12 (1):1-222 [PubMed]
• Colak S., Medema J. P. Human colonic fibroblasts regulate stemness and chemotherapy resistance of colon cancer stem cells Cell cycle (Georgetown, Tex.) 2016;15 (12):1531-1537 [PubMed]
• den Uil Sjoerd H., Coupé Veerle M. H., Linnekamp Janneke F., van den Broek Evert, Goos Jeroen A. C. M., Delis-van Diemen Pien M., Belt Eric J. Th, van Grieken Nicole C. T., Scott Patricia M., Vermeulen Louis, Medema Jan Paul, Bril Herman, Stockmann Hein B. A. C., Cormier Robert T., Meijer Gerrit A., Fijneman Remond J. A. Loss of KCNQ1 expression in stage II and stage III colon cancer is a strong prognostic factor for disease recurrence British journal of cancer 2016;115 (12):1565-1574 [PubMed]
• Domingo Enric, Freeman-Mills Luke, Rayner Emily, Glaire Mark, Briggs Sarah, Vermeulen Louis, Fessler Evelyn, Medema Jan Paul, Boot Arnoud, Morreau Hans, van Wezel Tom, Liefers Gerrit-Jan, Lothe Ragnhild A., Danielsen Stine A., Sveen Anita, Nesbakken Arild, Zlobec Inti, Lugli Alessandro, Koelzer Viktor H., Berger Martin D., Castellví-Bel Sergi, Muñoz Jenifer, de Bruyn Marco, Nijman Hans W., Novelli Marco, Lawson Kay, Oukrif Dahmane, Frangou Eleni, Dutton Peter, Tejpar Sabine, Delorenzi Mauro, Kerr Rachel, Kerr David, Tomlinson Ian, Church David N. Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study lancet. Gastroenterology & hepatology 2016;1 (3):207-216 [PubMed]
• Colak Selçuk Targeting cancer stem cells: Modulating apoptosis and stemness 2016. 235p. ISBN 9789402801958. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Medema J. P.; Co-supervisor: van den Brink G. R.)
• van Oorschot Bregje, Granata Giovanna, Di Franco Simone, ten Cate Rosemarie, Rodermond Hans M., Todaro Matilde, Medema Jan Paul, Franken Nicolaas A. P. Targeting DNA double strand break repair with hyperthermia and DNA-PKcs inhibition to enhance the effect of radiation treatment Oncotarget 2016;7 (40):65504-65513 [PubMed]
• Fessler Evelyn, Drost Jarno, van Hooff Sander R., Linnekamp Janneke F., Wang Xin, Jansen Marnix, de Sousa E Melo Felipe, Prasetyanti Pramudita R., IJspeert Joep Eg, Franitza Marek, Nürnberg Peter, van Noesel Carel Jm, Dekker Evelien, Vermeulen Louis, Clevers Hans, Medema Jan Paul TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype EMBO molecular medicine 2016;8 (7):745-760 [PubMed]
• van Oorschot Bregje Tumor control and normal tissue toxicity: The two faces of radiotherapy 2016. 165p. ISBN 9789461827104. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Medema J. P., Stalpers L. J. A.; Co-supervisors: Franken N. A. P., Vrieling H.)
• Di Franco Simone, Turdo Alice, Benfante Antonina, Colorito Maria L., Gaggianesi Miriam, Apuzzo Tiziana, Kandimalla Raju, Chinnici Aurora, Barcaroli Daniela, Mangiapane Laura Rosa, Pistone Giuseppe, Vieni Salvatore, Gulotta Eliana, Dieli Francesco, Medema Jan Paul, Stassi Giorgio, de Laurenzi Vincenzo, Todaro Matilde ΔNp63 drives metastasis in breast cancer cells via PI3K/CD44v6 axis Oncotarget 2016;7 (34):54157-54173 [PubMed]

2015

• Damhofer Helene, Veenstra Veronique L., Tol Johanna A. M. G., van Laarhoven Hanneke W. M., Medema Jan Paul, Bijlsma Maarten F. Blocking Hedgehog release from pancreatic cancer cells increases paracrine signaling potency Journal of cell science 2015;128 (1):129-139 [PubMed]
• Lascano V., Hahne M., Papon L., Cameron K., Röeder C., Schafmayer C., Driessen L., Van Eenennaam H., Kalthoff H., Medema J. P. Circulating APRIL levels are correlated with advanced disease and prognosis in rectal cancer patients Oncogenesis 2015;4
• Lascano V., Hahne M., Papon L., Cameron K., Röeder C., Schafmayer C., Driessen L., van Eenennaam H., Kalthoff H., Medema J. P. Circulating APRIL levels are correlated with advanced disease and prognosis in rectal cancer patients Oncogenesis 2015;4:e136 [PubMed]
• Linnekamp Janneke F., Wang Xin, Medema Jan Paul, Vermeulen Louis Colorectal cancer heterogeneity and targeted therapy: a case for molecular disease subtypes Cancer research 2015;75 (2):245-249 [PubMed]
• IJspeert Joep Evert Godfried, Medema Jan Paul, Dekker Evelien Colorectal neoplasia pathways: state of the art Gastrointestinal endoscopy clinics of North America 2015;25 (2):169-182 [PubMed]
• Calpe Silvia, Wagner Koen, El Khattabi Mohamed, Rutten Lucy, Zimberlin Cheryl, Dolk Edward, Verrips C. Theo, Medema Jan Paul, Spits Hergen, Krishnadath Kausilia K. Effective Inhibition of Bone Morphogenetic Protein Function by Highly Specific Llama-Derived Antibodies Molecular cancer therapeutics 2015;14 (11):2527-2540 [PubMed]
• Fessler Evelyn, Borovski Tijana, Medema Jan Paul Endothelial cells induce cancer stem cell features in differentiated glioblastoma cells via bFGF Molecular cancer 2015;14 (1):157 [PubMed]
• Prasetyanti Pramudita R., Capone Emily, Barcaroli Daniela, D'Agostino Daniela, Volpe Silvia, Benfante Antonina, van Hooff Sander, Iacobelli Valentina, Rossi Cosmo, Iacobelli Stefano, Medema Jan Paul, de Laurenzi Vincenzo, Sala Gianluca ErbB-3 activation by NRG-1β sustains growth and promotes vemurafenib resistance in BRAF-V600E colon cancer stem cells (CSCs) Oncotarget 2015;6 (19):16902-16911 [PubMed]
• Wielenga Mattheus C. B., Colak Selcuk, Heijmans Jarom, van Lidth de Jeude Jooske F., Rodermond Hans M., Paton James C., Paton Adrienne W., Vermeulen Louis, Medema Jan Paul, van den Brink Gijs R. ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy Cell reports 2015;13 (3):490-494 [PubMed]
• Galluzzi L., Bravo-San Pedro J. M., Vitale I., Aaronson S. A., Abrams J. M., Adam D., Alnemri E. S., Altucci L., Andrews D., Annicchiarico-Petruzzelli M., Baehrecke E. H., Bazan N. G., Bertrand M. J., Bianchi K., Blagosklonny M. V., Blomgren K., Borner C., Bredesen D. E., Brenner C., Campanella M., Candi E., Cecconi F., Chan F. K., Chandel N. S., Cheng E. H., Chipuk J. E., Cidlowski J. A., Ciechanover A., Dawson T. M., Dawson V. L., de Laurenzi V., de Maria R., Debatin K.-M., Di Daniele N., Dixit V. M., Dynlacht B. D., El-Deiry W. S., Fimia G. M., Flavell R. A., Fulda S., Garrido C., Gougeon M.-L., Green D. R., Gronemeyer H., Hajnoczky G., Hardwick J. M., Hengartner M. O., Ichijo H., Joseph B., Jost P. J., Kaufmann T., Kepp O., Klionsky D. J., Knight R. A., Kumar S., Lemasters J. J., Levine B., Linkermann A., Lipton S. A., Lockshin R. A., López-Otín C., Lugli E., Madeo F., Malorni W., Marine J.-C., Martin S. J., Martinou J.-C., Medema J. P., Meier P., Melino S., Mizushima N., Moll U., Muñoz-Pinedo C., Nuñez G., Oberst A., Panaretakis T., Penninger J. M., Peter M. E., Piacentini M., Pinton P., Prehn J. H., Puthalakath H., Rabinovich G. A., Ravichandran K. S., Rizzuto R., Rodrigues C. M., Rubinsztein D. C., Rudel T., Shi Y., Simon H.-U., Stockwell B. R., Szabadkai G., Tait S. W., Tang H. L., Tavernarakis N., Tsujimoto Y., Vanden Berghe T., Vandenabeele P., Villunger A., Wagner E. F., Walczak H., White E., Wood W. G., Yuan J., Zakeri Z., Zhivotovsky B., Melino G., Kroemer G. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015 Cell death and differentiation 2015;22 (1):58-73 [PubMed]
• Damhofer Helene, Ebbing Eva A., Steins Anne, Welling Lieke, Tol Johanna A., Krishnadath Kausilia K., van Leusden Tom, van de Vijver Marc J., Besselink Marc G., Busch Olivier R., van Berge Henegouwen Mark I., van Delden Otto, Meijer Sybren L., Dijk Frederike, Medema Jan Paul, van Laarhoven Hanneke W., Bijlsma Maarten F. Establishment of patient-derived xenograft models and cell lines for malignancies of the upper gastrointestinal tract Journal of translational medicine 2015;13 (1):115 [PubMed]
• Zimberlin Cheryl D., Lancini Cesare, Sno Rachel, Rosekrans Sanne L., McLean Chelsea M., Vlaming Hanneke, van den Brink Gijs R., Bots Michael, Medema Jan Paul, Dannenberg Jan-Hermen HDAC1 and HDAC2 collectively regulate intestinal stem cell homeostasis FASEB journal 2015;29 (5):2070-2080 [PubMed]
• Oei Arlene L., van Leeuwen Caspar M., ten Cate Rosemarie, Rodermond Hans M., Buist Marrije R., Stalpers Lukas J. A., Crezee Johannes, Kok H. Petra, Medema Jan Paul, Franken Nicolaas A. P. Hyperthermia Selectively Targets Human Papillomavirus in Cervical Tumors via p53-Dependent Apoptosis Cancer research 2015;75 (23):5120-5129 [PubMed]
• Tirinato Luca, Liberale Carlo, Di Franco Simone, Candeloro Patrizio, Benfante Antonina, La Rocca Rosanna, Potze Lisette, Marotta Roberto, Ruffilli Roberta, Rajamanickam Vijayakumar P., Malerba Mario, de Angelis Francesco, Falqui Andrea, Carbone Ennio, Todaro Matilde, Medema Jan Paul, Stassi Giorgio, Di Fabrizio Enzo Lipid droplets: a new player in colorectal cancer stem cells unveiled by spectroscopic imaging Stem cells (Dayton, Ohio) 2015;33 (1):35-44 [PubMed]
• Potze Lisette Mechanisms of Betulinic acid-induced cell death 2015. 199p. ISBN 9789462992016. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Medema J. P.; Co-supervisors: Kessler J. H., Vaz F. M.)
• Damhofer Helene Opening new doors: Hedgehog signaling and the pancreatic cancer stroma 2015. 191p. ISBN 9789461825452. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Medema J. P.; Co-supervisor: Bijlsma M. F.)
• Drost Jarno, van Jaarsveld Richard H., Ponsioen Bas, Zimberlin Cheryl, van Boxtel Ruben, Buijs Arjan, Sachs Norman, Overmeer René M., Offerhaus G. Johan, Begthel Harry, Korving Jeroen, van de Wetering Marc, Schwank Gerald, Logtenberg Meike, Cuppen Edwin, Snippert Hugo J., Medema Jan Paul, Kops Geert J. P. L., Clevers Hans Sequential cancer mutations in cultured human intestinal stem cells Nature 2015;521 (7550):43-37 [PubMed]
• Büller Nikè V. J. A., Rosekrans Sanne L., Metcalfe Ciara, Heijmans Jarom, van Dop Willemijn A., Fessler Evelyn, Jansen Marnix, Ahn Christina, Vermeulen Jacqueline L. M., Westendorp B. Florien, Robanus-Maandag Els C., Offerhaus G. Johan, Medema Jan Paul, D'Haens Geert R. A. M., Wildenberg Manon E., de Sauvage Frederic J., Muncan Vanesa, van den Brink Gijs R. Stromal Indian hedgehog signaling is required for intestinal adenoma formation in mice Gastroenterology 2015;148 (1):170-180.e6 [PubMed]
• Guinney Justin, Dienstmann Rodrigo, Wang Xin, de Reyniès Aurélien, Schlicker Andreas, Soneson Charlotte, Marisa Laetitia, Roepman Paul, Nyamundanda Gift, Angelino Paolo, Bot Brian M., Morris Jeffrey S., Simon Iris M., Gerster Sarah, Fessler Evelyn, de Sousa E Melo Felipe, Missiaglia Edoardo, Ramay Hena, Barras David, Homicsko Krisztian, Maru Dipen, Manyam Ganiraju C., Broom Bradley, Boige Valerie, Perez-Villamil Beatriz, Laderas Ted, Salazar Ramon, Gray Joe W., Hanahan Douglas, Tabernero Josep, Bernards Rene, Friend Stephen H., Laurent-Puig Pierre, Medema Jan Paul, Sadanandam Anguraj, Wessels Lodewyk, Delorenzi Mauro, Kopetz Scott, Vermeulen Louis, Tejpar Sabine The consensus molecular subtypes of colorectal cancer Nature medicine 2015;21 (11):1350-1356 [PubMed]

2014

• Potze L., Mullauer F. B., Colak S., Kessler J. H., Medema J. P. Betulinic acid-induced mitochondria-dependent cell death is counterbalanced by an autophagic salvage response Cell death & disease 2014;5:e1169 [PubMed]
• Colak Selcuk, Medema Jan P. Cancer stem cells--important players in tumor therapy resistance FEBS journal 2014;281 (21):4779-4791 [PubMed]
• Colak S., Zimberlin C. D., Fessler E., Hogdal L., Prasetyanti P. R., Grandela C. M., Letai A., Medema J. P. Decreased mitochondrial priming determines chemoresistance of colon cancer stem cells Cell death and differentiation 2014;21 (7):1170-1177 [PubMed]
• Grabinger T., Luks L., Kostadinova F., Zimberlin C., Medema J. P., Leist M., Brunner T. Ex vivo culture of intestinal crypt organoids as a model system for assessing cell death induction in intestinal epithelial cells and enteropathy Cell death & disease 2014;5:e1228 [PubMed]
• Sadanandam Anguraj, Wang Xin, de Sousa E Melo Felipe, Gray Joe W., Vermeulen Louis, Hanahan Douglas, Medema Jan Paul Reconciliation of classification systems defining molecular subtypes of colorectal cancer: interrelationships and clinical implications Cell cycle (Georgetown, Tex.) 2014;13 (3):353-357 [PubMed]
• van Oorschot Bregje, Hovingh Suzanne E., Moerland Perry D., Medema Jan Paul, Stalpers Lukas J. A., Vrieling Harry, Franken Nicolaas A. P. Reduced activity of double-strand break repair genes in prostate cancer patients with late normal tissue radiation toxicity International journal of radiation oncology, biology, physics 2014;88 (3):664-670 [PubMed]
• Lascano Valeria The role of APRIL (TNFSF13) in carcinogenesis 2014. 167p. ISBN 9789461825063. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Medema J. P.)
• Rocha Cecilia, Papon Laura, Cacheux Wulfran, Marques Sousa Patricia, Lascano Valeria, Tort Olivia, Giordano Tiziana, Vacher Sophie, Lemmers Benedicte, Mariani Pascale, Meseure Didier, Medema Jan Paul, Bièche Ivan, Hahne Michael, Janke Carsten Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon EMBO journal 2014;33 (19):2247-2260 [PubMed]
• Rocha Cecilia, Papon Laura, Cacheux Wulfran, Marques Sousa Patricia, Lascano Valeria, Tort Olivia, Giordano Tiziana, Vacher Sophie, Lemmers Benedicte, Mariani Pascale, Meseure Didier, Medema Jan Paul, Bièche Ivan, Hahne Michael, Janke Carsten Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon (vol 33, pg 2247, 2014) EMBO journal 2014;33 (22):2735 [PubMed]
• Medema J. P. Welcome to the next step for Oncogenesis Oncogenesis 2014;3:e130 [PubMed]

2013

• Damhofer Helene, Medema Jan Paul, Veenstra Veronique L., Badea Liviu, Popescu Irinel, Roelink Henk, Bijlsma Maarten F. Assessment of the stromal contribution to Sonic Hedgehog-dependent pancreatic adenocarcinoma Molecular oncology 2013;7 (6):1031-1042 [PubMed]
• de Sousa E Melo Felipe, Vermeulen Louis, Fessler Evelyn, Medema Jan Paul Cancer heterogeneity--a multifaceted view EMBO reports 2013;14 (8):686-695 [PubMed]
• Fessler Evelyn, Dijkgraaf Feline E., de Sousa E Melo Felipe, Medema Jan Paul Cancer stem cell dynamics in tumor progression and metastasis: Is the microenvironment to blame? Cancer letters 2013;341 (1):97-104 [PubMed]
• Medema Jan Paul Cancer stem cells: the challenges ahead Nature cell biology 2013;15 (4):338-344 [PubMed]
• Zeilstra Jurrit, Joosten Sander P. J., Vermeulen Louis, Koster Jan, Medema Jan Paul, Versteeg Rogier, Spaargaren Marcel, Pals Steven T. CD44 expression in intestinal epithelium and colorectal cancer is independent of p53 status PLoS ONE 2013;8 (8):e72849 [PubMed]
• Lascano Valeria, Guadagnoli Marco, Schot Jan G., Luijks Dieuwertje M., Guikema Jeroen E. J., Cameron Katherine, Hahne Michael, Pals Steven, Slinger Erik, Kipps Thomas J., van Oers Marinus H. J., Eldering Eric, Medema Jan Paul, Kater Arnon P. Chronic lymphocytic leukemia disease progression is accelerated by APRIL-TACI interaction in the TCL1 transgenic mouse model Blood 2013;122 (24):3960-3963 [PubMed]
• de Sousa E Melo Felipe Colon cancer heterogeneity: stem cells, signals and subtypes 2013. 203p. ISBN 9878946182326. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Medema J. P.; Co-supervisor: Vermeulen L.)
• Vermeulen L., Medema J. P. De pathogenese van dikkedarmkankerin: C. J. A. Punt, C. A. M. Marijnen, I. D. Nagtegaal, C. J. H. van de Velde, editors. Handboek colorectaal carcinoom. Utrecht: De Tijdstroom; 2013. p. 37-46, ISBN 9789058981967
• Wang Xin, Markowetz Florian, de Sousa E Melo Felipe, Medema Jan Paul, Vermeulen Louis Dissecting cancer heterogeneity--an unsupervised classification approach international journal of biochemistry & cell biology 2013;45 (11):2574-2579 [PubMed]
• Bergs Judith W. J., Krawczyk Przemek M., Borovski Tijana, ten Cate Rosemarie, Rodermond Hans M., Stap Jan, Medema Jan Paul, Haveman Jaap, Essers Jeroen, van Bree Chris, Stalpers Lukas J. A., Kanaar Roland, Aten Jacob A., Franken Nicolaas A. P. Inhibition of homologous recombination by hyperthermia shunts early double strand break repair to non-homologous end-joining DNA repair 2013;12 (1):38-45 [PubMed]
• Prasetyanti Pramudita R., Zimberlin Cheryl, de Sousa E Melo Felipe, Medema Jan Paul Isolation and propagation of colon cancer stem cells Methods in molecular biology (Clifton, N.J.) 2013;1035:247-259 [PubMed]
• Huels David J., Cammareri Patrizia, Ridgway Rachel A., Medema Jan P., Sansom Owen J. Methods to assess Myc function in intestinal homeostasis, regeneration, and tumorigenesis Methods in molecular biology (Clifton, N.J.) 2013;1012:237-248 [PubMed]
• Balzarolo Melania, Watzl Carsten, Medema Jan Paul, Wolkers Monika C. NAB2 and EGR-1 exert opposite roles in regulating TRAIL expression in human Natural Killer cells Immunology letters 2013;151 (1-2):61-67 [PubMed]
• Balzarolo Melania On the TRAIL of innate immune responses. Plasmacytoid dendritic cells and beyond 2013. 155p. ISBN 9789461823120. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Medema J. P.; Co-supervisor: Wolkers M. C.)
• de Sousa E Melo Felipe, Wang Xin, Jansen Marnix, Fessler Evelyn, Trinh Anne, de Rooij Laura P. M. H., de Jong Joan H., de Boer Onno J., van Leersum Ronald, Bijlsma Maarten F., Rodermond Hans, van der Heijden Maartje, van Noesel Carel J. M., Tuynman Jurriaan B., Dekker Evelien, Markowetz Florian, Medema Jan Paul, Vermeulen Louis Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions Nature medicine 2013;19 (5):614-618 [PubMed]
• Prasetyanti Pramudita Ramadhina, Zimberlin Cheryl Doreen, Bots Michael, Vermeulen Louis, Melo Felipe De Sousa E., Medema Jan Paul Regulation of stem cell self-renewal and differentiation by Wnt and Notch are conserved throughout the adenoma-carcinoma sequence in the colon Molecular cancer 2013;12 (1):126 [PubMed]
• Guadagnoli Marco Targeting APRIL 2013. 135p. ISBN 9789461822802. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Medema J. P.)
• Borovski T., Beke P., van Tellingen O., Rodermond H. M., Verhoeff J. J., Lascano V., Daalhuisen J. B., Medema J. P., Sprick M. R. Therapy-resistant tumor microvascular endothelial cells contribute to treatment failure in glioblastoma multiforme Oncogene 2013;32 (12):1539-1548 [PubMed]
• Fernandez Leticia, Salinas Gabriela Franco, Rocha Cecilia, Carvalho-Pinto Carla E., Yeremenko Nataliya, Papon Laura, Medema Jan Paul, Combe Bernard, Morel Jacques, Baeten Dominique, Hahne Michael The TNF family member APRIL dampens collagen-induced arthritis Annals of the rheumatic diseases 2013;72 (8):1367-1374 [PubMed]

2012

• de Sousa E Melo Felipe, Medema Jan Paul Axing Wnt signals Cell research 2012;22 (1):9-11 [PubMed]
• Borovski Tijana Cancer stem cell niche: the place to be 2012. 157p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Medema Jan P.; Co-supervisors: Sprick M. R., Franken N. A. P.)
• Krawczyk P. M., Borovski T., Stap J., Cijsouw T., ten Cate R., Medema J. P., Kanaar R., Franken N. A. P., Aten J. A. Chromatin mobility is increased at sites of DNA double-strand breaks Journal of cell science 2012;125 (9):2127-2133 [PubMed]
• Rosati Alessandra, Bersani Samantha, Tavano Francesca, Dalla Pozza Elisa, de Marco Margot, Palmieri Marta, de Laurenzi Vincenzo, Franco Renato, Scognamiglio Giosuè, Palaia Raffaele, Fontana Andrea, di Sebastiano Pierluigi, Donadelli Massimo, Dando Ilaria, Medema Jan Paul, Dijk Frederike, Welling Lieke, di Mola Fabio Francesco, Pezzilli Raffaele, Turco Maria Caterina, Scarpa Aldo Expression of the Antiapoptotic Protein BAG3 Is a Feature of Pancreatic Adenocarcinoma and Its Overexpression Is Associated With Poorer Survival American journal of pathology 2012;181 (5):1524-1529 [PubMed]
• de Jong Joan H., Rodermond Hans M., Zimberlin Cheryl D., Lascano Valeria, de Sousa E Melo Felipe, Richel Dick J., Medema Jan Paul, Vermeulen Louis Fusion of intestinal epithelial cells with bone marrow derived cells is dispensable for tissue homeostasis Scientific reports 2012;2:271 [PubMed]
• Kemper Kristel Molecular identification and targeting of colorectal cancer stem cells 2012. 182p. ISBN 9789085707882. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Medema Jan-Paul)
• Kemper Kristel, Prasetyanti Pramudita R., de Lau Wim, Rodermond Hans, Clevers Hans, Medema Jan Paul Monoclonal Antibodies Against Lgr5 Identify Human Colorectal Cancer Stem Cells Stem cells (Dayton, Ohio) 2012;30 (11):2378-2386 [PubMed]
• Kemper Kristel, Versloot Miranda, Cameron Katherine, Colak Selçuk, de Sousa E Melo Felipe, de Jong Joan H., Bleackley Joanne, Vermeulen Louis, Versteeg Rogier, Koster Jan, Medema Jan Paul Mutations in the Ras-Raf Axis Underlie the Prognostic Value of CD133 in Colorectal Cancer Clinical cancer research 2012;18 (11):3132-3141 [PubMed]
• Wolkers Monika C., Gerlach Carmen, Arens Ramon, Janssen Edith M., Fitzgerald Patrick, Schumacher Ton N., Medema Jan Paul, Green Douglas R., Schoenberger Stephen P. Nab2 regulates secondary CD8(+) T-cell responses through control of TRAIL expression Blood 2012;119 (3):798-804 [PubMed]
• Kemper Kristel, Medema Jan Paul Prognostic Value of CD133 Caused by Mutant K-Ras and B-Raf-Response Clinical cancer research 2012;18 (16):4474 [PubMed]
• Kemper Kristel, Rodermond Hans, Colak Selçuk, Grandela Catarina, Medema Jan Paul Targeting colorectal cancer stem cells with inducible caspase-9 Apoptosis 2012;17 (5):528-537 [PubMed]
• Kimberley Fiona C., van der Sloot Almer M., Guadagnoli Marco, Cameron Katherine, Schneider Pascal, Marquart J. Arnoud, Versloot Miranda, Serrano Luis, Medema Jan Paul The Design and Characterization of Receptor-selective APRIL Variants Journal of biological chemistry 2012;287 (44):37434-37446 [PubMed]
• Vermeulen Louis, de Sousa E Melo Felipe, Richel Dick J., Medema Jan Paul The developing cancer stem-cell model: clinical challenges and opportunities lancet oncology 2012;13 (2):E83-E89 [PubMed]
• Lascano V., Zabalegui L. F., Cameron K., Guadagnoli M., Jansen M., Burggraaf M., Versloot M., Rodermond H., van der Loos C., Carvalho-Pinto C. E., Kalthoff H., Medema J. P., Hahne M. The TNF family member APRIL promotes colorectal tumorigenesis Cell death and differentiation 2012;19 (11):1826-1835 [PubMed]
• Balzarolo Melania, Karrich Julien J., Engels Sander, Blom Bianca, Medema Jan Paul, Wolkers Monika C. The transcriptional regulator NAB2 reveals a two-step induction of TRAIL in activated plasmacytoid DCs European journal of immunology 2012;42 (11):3019-3027 [PubMed]

2011

• Kimberley Fiona, Guadagnoli Marco, van Eenennaam Hans, Medema Jan Paul A Proliferation-Inducing Ligand (APRIL): The Development of Antagonistic Agents as Potential Therapeutics and Deciphering the Role of Heparan Sulphate Proteoglycans (HSPGs) in APRIL Signalling Advances in experimental medicine and biology 2011;691:501-506 [PubMed]
• Mullauer Franziska B., van Bloois Louis, Daalhuisen Joost B., ten Brink Marieke S., Storm Gert, Medema Jan Paul, Schiffelers Raymond M., Kessler Jan H. Betulinic acid delivered in liposomes reduces growth of human lung and colon cancers in mice without causing systemic toxicity Anti-cancer drugs 2011;22 (3):223-233 [PubMed]
• Müllauer Franziska B. Betunic acid induced tumor killing 2011. 155p. ISBN 9789461820006. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Medema J. P.; Co-supervisor: Kessler J. H.)
• Borovski Tijana, de Sousa E Melo Felipe, Vermeulen Louis, Medema Jan Paul Cancer Stem Cell Niche: The Place to Be Cancer research 2011;71 (3):634-639 [PubMed]
• de Sousa E Melo F., Guessous I., Vermeulen L., Medema J. P. Cellules souches cancéreuses et futures modalités thérapeutiques du cancer Revue medicale suisse 2011;7 (289):774-777 [PubMed]
• Guadagnoli Marco, Kimberley Fiona, Phan Uyen, Cameron Katherine, Vink Paul, Rodermond Hans, Eldering Eric, Kater Arnon, van Eenennaam Hans, Medema Jan Paul Development and characterization of APRIL antagonistic monoclonal antibodies for treatment of B-cell lymphomas Blood 2011;117 (25):6856-6865 [PubMed]
• Lobito Adrian A., Gabriel Tanit L., Medema Jan Paul, Kimberley Fiona C. Disease causing mutations in the TNF and TNFR superfamilies: Focus on molecular mechanisms driving disease Trends in molecular medicine 2011;17 (9):494-505 [PubMed]
• Reijmers Rogier M., Groen Richard W. J., Kuil Annemieke, Weijer Kees, Kimberley Fiona C., Medema Jan Paul, van Kuppevelt Toin H., Li Jin-Ping, Spaargaren Marcel, Pals Steven T. Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival Blood 2011;117 (23):6162-6171 [PubMed]
• Afonina Inna S., Tynan Graham A., Logue Susan E., Cullen Sean P., Bots Michael, Lüthi Alexander U., Reeves Emer P., McElvaney Noel G., Medema Jan P., Lavelle Ed C., Martin Seamus J. Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1α Molecular cell 2011;44 (2):265-278 [PubMed]
• de Sousa E Melo Felipe, Colak Selcuk, Buikhuisen Joyce, Koster Jan, Cameron Kate, de Jong Joan H., Tuynman Jurriaan B., Prasetyanti Pramudita R., Fessler Evelyn, van den Bergh Saskia P., Rodermond Hans, Dekker Evelien, van der Loos Chris M., Pals Steven T., van de Vijver Marc J., Versteeg Rogier, Richel Dick J., Vermeulen Louis, Medema Jan Paul Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients Cell stem cell 2011;9 (5):476-485 [PubMed]
• Medema Jan Paul, Vermeulen Louis Microenvironmental regulation of stem cells in intestinal homeostasis and cancer Nature 2011;474 (7351):318-326 [PubMed]
• Bakema Jantine E., Ganzevles Sonja H., Fluitsma Donna M., Schilham Marco W., Beelen Robert H. J., Valerius Thomas, Lohse Stefan, Glennie Martin J., Medema Jan Paul, van Egmond Marjolein Targeting FcαRI on polymorphonuclear cells induces tumor cell killing through autophagy Journal of immunology (Baltimore, Md. 2011;187 (2):726-732 [PubMed]
• de Sousa E Melo Felipe, Vermeulen Louis, Richel Dick, Medema Jan Paul Targeting Wnt Signaling in Colon Cancer Stem Cells Clinical cancer research 2011;17 (4):647-653 [PubMed]

2010

• Mullauer Franziska B., Kessler Jan H., Medema Jan Paul Betulinic acid, a natural compound with potent anticancer effects Anti-cancer drugs 2010;21 (3):215-227 [PubMed]
• Vermeulen Louis Cancer stem cells - a numbers game? 2010. 224p. ISBN 9789090257105. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Medema J. P., Richel D. J.)
• Sottoriva Andrea, Verhoeff Joost J. C., Borovski Tijana, McWeeney Shannon K., Naumov Lev, Medema Jan Paul, Sloot Peter M. A., Vermeulen Louis Cancer Stem Cell Tumor Model Reveals Invasive Morphology and Increased Phenotypical Heterogeneity Cancer research 2010;70 (1):46-56 [PubMed]
• Medema J. P., Walczak H., Hahne M., de Laurenzi V. Cell death Cell death and differentiation 2010;17 (4):730-732
• Todaro Matilde, Francipane Maria Giovanna, Medema Jan Paul, Stassi Giorgio Colon Cancer Stem Cells: Promise of Targeted Therapy Gastroenterology 2010;138 (6):2151-2162 [PubMed]
• Rodermond Hans M., ten Cate Rosemarie, Haveman Jaap, van Kuilenburg Andre, Medema Jan Paul, van Bree Chris, Franken Nicolaas A. P. Cyclopentenylcytosine does not enhance cisplatin-induced radiosensitization in human lung tumour cells Oncology letters 2010;1 (3):537-540 [PubMed]
• Sottoriva Andrea, Sloot Peter M. A., Medema Jan Paul, Vermeulen Louis Exploring cancer stem cell niche directed tumor growth Cell cycle (Georgetown, Tex.) 2010;9 (8):1472-1479 [PubMed]
• Bem Reinout A., van Woensel Job B. M., Lutter Rene, Domachowske Joseph B., Medema Jan Paul, Rosenberg Helene F., Bos Albert P. Granzyme A- and B-Cluster Deficiency Delays Acute Lung Injury in Pneumovirus-Infected Mice Journal of immunology (Baltimore, Md. 2010;184 (2):931-938 [PubMed]
• Kemper Kristel, Grandela Catarina, Medema Jan Paul Molecular identification and targeting of colorectal cancer stem cells Oncotarget 2010;1 (6):387-395 [PubMed]
• Kemper Kristel, Tol Marc J. P. M., Medema Jan Paul Mouse Tissues Express Multiple Splice Variants of Prominin-1 PLoS ONE 2010;5 (8):e12325 [PubMed]
• de Bruijn M. T., Raats D. A. E., Hoogwater F. J. H., van Houdt W. J., Cameron K., Medema J. P., Borel Rinkes I. H. M., Kranenburg O. Oncogenic KRAS sensitises colorectal tumour cells to chemotherapy by p53-dependent induction of Noxa British journal of cancer 2010;102 (8):1254-1264 [PubMed]
• Hoogwater Frederik J. H., Nijkamp Maarten W., Smakman Niels, Steller Ernst J. A., Emmink Benjamin L., Westendorp B. Florien, Raats Danielle A. E., Sprick Martin R., Schaefer Uta, van Houdt Winan J., de Bruijn Menno T., Schackmann Ron C. J., Derksen Patrick W. B., Medema Jan-Paul, Walczak Henning, Borel Rinkes Inne H. M., Kranenburg Onno Oncogenic K-Ras Turns Death Receptors Into Metastasis-Promoting Receptors in Human and Mouse Colorectal Cancer Cells Gastroenterology 2010;138 (7):2357-2367 [PubMed]
• Kemper Kristel, Sprick Martin R., de Bree Martijn, Scopelliti Alessandro, Vermeulen Louis, Hoek Maarten, Zeilstra Jurrit, Pals Steven T., Mehmet Huseyin, Stassi Giorgio, Medema Jan Paul The AC133 Epitope, but not the CD133 Protein, Is Lost upon Cancer Stem Cell Differentiation Cancer research 2010;70 (2):719-729 [PubMed]
• Vermeulen Louis, de Sousa E Melo Felipe, van der Heijden Maartje, Cameron Kate, de Jong Joan H., Borovski Tijana, Tuynman Jurriaan B., Todaro Matilde, Merz Christian, Rodermond Hans, Sprick Martin R., Kemper Kristel, Richel Dick J., Stassi Giorgio, Medema Jan Paul Wnt activity defines colon cancer stem cells and is regulated by the microenvironment Nature cell biology 2010;12 (5):468-U121 [PubMed]

2009

• Kimberley Fiona C., Hahne Michael, Medema Jan Paul "APRIL hath put a spring of youth in everything": Relevance of APRIL for survival Journal of cellular physiology 2009;218 (1):1-8 [PubMed]
• Kimberley Fiona C., Medema Jan Paul, Hahne Michael APRIL in B-cell malignancies and autoimmunity Results and problems in cell differentiation 2009;49:161-182 [PubMed]
• Mullauer Franziska B., Kessler Jan H., Medema Jan Paul Betulinic acid induces cytochrome c release and apoptosis in a Bax/Bak-independent, permeability transition pore dependent fashion Apoptosis 2009;14 (2):191-202 [PubMed]
• Mullauer Franziska B., Kessler Jan H., Medema Jan Paul Betulin Is a Potent Anti-Tumor Agent that Is Enhanced by Cholesterol PLoS ONE 2009;4 (4):e1 [PubMed]
• Vermeulen Louis, Medema Jan Paul, Hardwick James C. H., van den Brink Gijs R. Cancer Stem Cells in Colorectal Cancerin: Sadhan Majumder, editors. Stem Cells and Cancer. Berlin; New York: Springer; 2009. p. 233-250, ISBN 9780387896113; 9780387896106
• Galluzzi L., Aaronson S. A., Abrams J., Alnemri E. S., Andrews D. W., Baehrecke E. H., Bazan N. G., Blagosklonny M. V., Blomgren K., Borner C., Bredesen D. E., Brenner C., Castedo M., Cidlowski J. A., Ciechanover A., Cohen G. M., de Laurenzi V., de Maria R., Deshmukh M., Dynlacht B. D., El-Deiry W. S., Flavell R. A., Fulda S., Garrido C., Golstein P., Gougeon M.-L., Green D. R., Gronemeyer H., Hajnóczky G., Hardwick J. M., Hengartner M. O., Ichijo H., Jäättelä M., Kepp O., Kimchi A., Klionsky D. J., Knight R. A., Kornbluth S., Kumar S., Levine B., Lipton S. A., Lugli E., Madeo F., Malorni W., Marine J.-Cw, Martin S. J., Medema J. P., Mehlen P., Melino G., Moll U. M., Morselli E., Nagata S., Nicholson D. W., Nicotera P., Nuñez G., Oren M., Penninger J., Pervaiz S., Peter M. E., Piacentini M., Prehn J. H. M., Puthalakath H., Rabinovich G. A., Rizzuto R., Rodrigues C. M. P., Rubinsztein D. C., Rudel T., Scorrano L., Simon H.-U., Steller H., Tschopp J., Tsujimoto Y., Vandenabeele P., Vitale I., Vousden K. H., Youle R. J., Yuan J., Zhivotovsky B., Kroemer G. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes Cell death and differentiation 2009;16 (8):1093-1107 [PubMed]
• Vermeulen Louis, Verhoeff Joost J. C., Richel Dick J., Medema Jan Paul Kankerstamcellen Nederlands tijdschrift voor geneeskunde 2009;153 (7):286-290 [PubMed]
• Cullen Sean P., Afonina Inna S., Donadini Roberta, Lüthi Alexander U., Medema Jan Paul, Bird Phillip I., Martin Seamus J. Nucleophosmin Is Cleaved and Inactivated by the Cytotoxic Granule Protease Granzyme M during Natural Killer Cell-mediated Killing Journal of biological chemistry 2009;284 (8):5137-5147 [PubMed]
• Borovski Tijana, Vermeulen L., Sprick M. R., Medema J. P. One renegade cancer stem cell? Cell cycle (Georgetown, Tex.) 2009;8 (6):803-808 [PubMed]
• Vermeulen L., Todaro M., De Sousa Mello F., Sprick M. R., Kemper K., Perez Alea M., Richel D. J., Stassi G., Medema J. P. Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity (Proceedings of the National Academy of Sciences of the United States of America (2008) 105, 36, (13427-13432) DOI 10.1073/pnas. 0805706105) Proceedings of the National Academy of Sciences of the United States of America 2009;106 (23):9534
• Kimberley Fiona C., van Bostelen Liesbeth, Cameron Katherine, Hardenberg Gijs, Marquart J. Arnoud, Hahne Michael, Medema Jan Paul The proteoglycan (heparan sulfate proteoglycan) binding domain of APRIL serves as a platform for ligand multimerization and cross-linking FASEB journal 2009;23 (5):1584-1595 [PubMed]
• Bergs J. W. J., ten Cate R., Rodermond H. M., Jaarsma P. A., Medema J. P., Darroudi F., Buist M. R., Stalpers L. J. A., Haveman J., van Bree C., Franken N. A. P. Transient inhibition of Calyculin A induced premature chromosome condensation by hyperthermia International journal of hyperthermia 2009;25 (3):220-228 [PubMed]
• Borovski Tijana, Verhoeff Joost J. C., ten Cate Rosemarie, Cameron Kate, de Vries Nienke A., van Tellingen Olaf, Richel Dirk J., van Furth Wouter R., Medema Jan Paul, Sprick Martin R. Tumor microvasculature supports proliferation and expansion of glioma-propagating cells International journal of cancer. Journal international du cancer 2009;125 (5):1222-1230 [PubMed]

2008

• Bem Reinout A., Bos Albert P., Bots Michael, Wolbink Angela M., van Ham S. Marieke, Medema Jan Paul, Lutter Rene, van Woensel Job B. M. Activation of the granzyme pathway in children with severe respiratory syncytial virus infection Pediatric research 2008;63 (6):650-655 [PubMed]
• de Bruin Elza C., Medema Jan Paul Apoptosis and non-apoptotic deaths in cancer development and treatment response Cancer treatment reviews 2008;34 (8):737-749 [PubMed]
• de Bruin Elza Apoptosis in cancer - regulation and prognostic value 2008. 208p. ISBN 9789090228204. [UvA Dissertations Online] LUMC, Leiden: Klinische oncologie. (Supervisors: Nortier J. W. R., van de Velde C. J. H., Medema J. P.; Co-supervisor: Marijnen Corrie A. M.)
• Hardenberg Gijs, van der Sluijs Koen, van der Poll Tom, Medema Jan Paul APRIL affects antibody responses and early leukocyte infiltration, but not influenza A viral control Molecular immunology 2008;45 (11):3050-3058 [PubMed]
• Hardenberg Gijs, Fernandez Leticia, Hendriks Jenny, Chebli Karim, Jacquet Chantal, Sitbon Marc, Hahne Michel, Medema Jan Paul APRIL facilitates viral-induced erythroleukemia but is dispensable for T cell immunity and lymphomagenesis Journal of leukocyte biology 2008;84 (2):380-388 [PubMed]
• Vermeulen L., Sprick M. R., Kemper K., Stassi G., Medema J. P. Cancer stem cells--old concepts, new insights Cell death and differentiation 2008;15 (6):947-958 [PubMed]
• Bergs J. W. J., ten Cate R., Haveman J., Medema J. P., Franken N. A. P., van Bree C. Chromosome Fragments have the Potential to Predict Hyperthermia-induced Radio-sensitization in Two Different Human Tumor Cell Lines Journal of radiation research 2008;49 (5):465-472 [PubMed]
• Francipane Maria Giovanna, Alea Mileidys Perez, Lombardo Ylenia, Todaro Matilde, Medema J. P., Stassi Giorgio Crucial role of interleukin-4 in the survival of colon cancer stem cells Cancer research 2008;68 (11):4022-4025 [PubMed]
• van Bree C., Rodermond H. M., Leen R., Medema J. P., van Kuilenburg A. B. P. Cyclopentenyl cytosine increases gemcitabine radiosensitisation in human pancreatic cancer cells British journal of cancer 2008;98 (7):1226-1233 [PubMed]
• de Bruin Elza C., van de Velde Cornelis J. H., van Krieken J. Han J. M., Marijnen Corrie A. M., Medema Jan Paul Epithelial human leukocyte antigen-DR expression predicts reduced recurrence rates and prolonged survival in rectal cancer patients Clinical cancer research 2008;14 (4):1073-1079 [PubMed]
• van Bree Chris, Rodermond Hans M., ten Cate Rosemarie, de Vos Judith, Stalpers Lukas J. A., Haveman Jaap, Medema Jan Paul, Franken Nicolaas A. P. G0 cell cycle arrest alone is insufficient for enabling the repair of ionizing radiation-induced potentially lethal damage Radiation research 2008;170 (2):184-191 [PubMed]
• Todaro Matilde, Perez Alea Mileidys, Scopelliti Alessandro, Medema Jan Paul, Stassi Giorgio IL-4-mediated drug resistance in colon cancer stem cells Cell cycle (Georgetown, Tex.) 2008;7 (3):309-313 [PubMed]
• Bots Michael, Medema Jan Paul Serpins in T cell immunity Journal of leukocyte biology 2008;84 (5):1238-1247 [PubMed]
• Vermeulen L., Todaro M., de Sousa E Melo F., Sprick M. R., Kemper K., Alea M. Perez, Richel D. J., Stassi G., Medema J. P. Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity Proceedings of the National Academy of Sciences of the United States of America 2008;105 (36):13427-13432 [PubMed]
• Planelles Lourdes, Medema Jan Paul, Hahne Michael, Hardenberg Gijs The Expanding Role of APRIL in Cancer and Immunity Current molecular medicine 2008;8 (8):829-844 [PubMed]
• Hardenberg Gijs The role of APRIL in immunity and tumorigenicity 2008. 191p. ISBN 9789064642418. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Medema J. P.)
• Hardenberg Gijs, van Bostelen Liesbeth, Hahne Michael, Medema Jan Paul Thymus-independent class switch recombination is affected by APRIL Immunology and cell biology 2008;86 (6):530-534 [PubMed]

2007

• Planelles Lourdes, Castillo-Gutiérrez Sonia, Medema Jan Paul, Morales-Luque Antonio, Merle-Béral Hélène, Hahne Michael APRIL but not BLyS serum levels are increased in chronic lymphocytic leukemia: prognostic relevance of APRIL for survival Haematologica 2007;92 (9):1284-1285 [PubMed]
• Kessler Jan H., Mullauer Franziska B., de Roo Guido M., Medema Jan Paul Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types Cancer letters 2007;251 (1):132-145 [PubMed]
• Hulsman Niels, Medema Jan Paul, Bos Carina, Jongejan Aldo, Leurs Rob, Smit Martine J., de Esch Iwan J. P., Richel Dick, Wijtmans Maikel Chemical insights in the concept of hybrid drugs: the antitumor effect of nitric oxide-donating aspirin involves a quinone methide but not nitric oxide nor aspirin Journal of medicinal chemistry 2007;50 (10):2424-2431 [PubMed]
• Todaro Matilde, Alea Mileidys Perez, Di Stefano Anna B., Cammareri Patrizia, Vermeulen Louis, Iovino Flora, Tripodo Claudio, Russo Antonio, Gulotta Gaspare, Medema Jan Paul, Stassi Giorgio Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4 Cell stem cell 2007;1 (4):389-402 [PubMed]
• Bergs Judith W. J., Haveman Jaap, ten Cate Rosemarie, Medema Jan Paul, Franken Nicolaas A. P., van Bree Chris Effect of 41 degrees C and 43 degrees C on cisplatin radiosensitization in two human carcinoma cell lines with different sensitivities for cisplatin Oncology reports 2007;18 (1):219-226 [PubMed]
• de Bruin Elza C., van de Pas Simone, van de Velde Cornelis J. H., van Krieken J. Han J. M., Peltenburg Lucy T. C., Marijnen Corrie A. M., Medema Jan Paul Gene expression profiling reveals two separate mechanisms regulating apoptosis in rectal carcinomas in vivo Apoptosis 2007;12 (9):1671-1680 [PubMed]
• Bots Michael, de Bruin Elza, Rademaker-Koot Mirjam T. G. A., Medema Jan Paul Proteinase inhibitor-9 expression is induced by maturation in dendritic cells via p38 MAP kinase Human immunology 2007;68 (12):959-964 [PubMed]
• Hardenberg Gijs, Planelles Lourdes, Schwarte Carla M., van Bostelen Liesbeth, Le Huong Tran, Hahne Michael, Medema Jan Paul Specific TLR ligands regulate APRIL secretion by dendritic cells in a PKR-dependent manner European journal of immunology 2007;37 (10):2900-2911 [PubMed]
• Bots Michael The role of serine protease inhibitors in the modulation of anti-tumor immune responses 2007. 148p. ISBN 9789064641107. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Medema Jan Paul)

2006

• Griffioen Marieke, Kessler Jan H., Borghi Martina, van Soest Ronald A., van der Minne Caroline E., Nouta Jan, van der Burg Sjoerd H., Medema Jan Paul, Schrier Peter I., Falkenburg J. H. Frederik, Osanto Susanne, Melief Cornelis J. M. Detection and functional analysis of CD8+ T cells specific for PRAME: a target for T-cell therapy Clinical cancer research 2006;12 (10):3130-3136 [PubMed]
• Bots Michael, Offringa Rienk, Medema Jan Paul Does the serpin PI-9 protect tumor cells? Blood 2006;107 (12):4974-5; author reply 4975 [PubMed]
• Bots Michael, Medema Jan Paul Granzymes at a glance Journal of cell science 2006;119 (24):5011-5014 [PubMed]
• van de Linde P., Tysma O. M. H., Medema J. P., Hale G., Waldmann H., Roelen D. L., Roep B. O. Mechanisms of antibody immunotherapy on clonal islet reactive T cells Human immunology 2006;67 (4-5):264-273 [PubMed]
• de Bruin Elza C., van de Velde Cornelis J. H., van de Pas Simone, Nagtegaal Iris D., van Krieken J. Han J. M., Gosens Marleen J. E. M., Peltenburg Lucy T. C., Medema Jan Paul, Marijnen Corrie A. M. Prognostic value of apoptosis in rectal cancer patients of the dutch total mesorectal excision trial: radiotherapy is redundant in intrinsically high-apoptotic tumors Clinical cancer research 2006;12 (21):6432-6436 [PubMed]
• Bots Michael, van Bostelen Liesbeth, Rademaker Mirjam Tga, Offringa Rienk, Medema Jan Paul Serpins prevent granzyme-induced death in a species-specific manner Immunology and cell biology 2006;84 (1):79-86 [PubMed]

2005

• Peltenburg L. T. C., de Bruin E. C., Meersma D., Smit N. P. M., Schrier P. I., Medema J. P. Expression and function of the apoptosis effector Apaf-1 in melanoma Cell death and differentiation 2005;12 (6):678-679 [PubMed]
• Hendriks J., Planelles L., de Jong-Odding J., Hardenberg G., Pals S. T., Hahne M., Spaargaren M., Medema J. P. Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation Cell death and differentiation 2005;12 (6):637-648 [PubMed]
• de Bruin Elza C., van de Pas Simone, Lips Esther H., van Eijk Ronald, van der Zee Minke M. C., Lombaerts Marcel, van Wezel Tom, Marijnen Corrie A. M., van Krieken J. Han J. M., Medema Jan Paul, van de Velde Cornelis J. H., Eilers Paul H. C., Peltenburg Lucy T. C. Macrodissection versus microdissection of rectal carcinoma: minor influence of stroma cells to tumor cell gene expression profiles BMC genomics 2005;6:142 [PubMed]
• Bots Michael, Kolfschoten Ingrid G. M., Bres Sandra A., Rademaker Mirjam T. G. A., de Roo Guido M., Krüse Margreet, Franken Kees L. M. C., Hahne Michael, Froelich Christopher J., Melief Cornelis J. M., Offringa Rienk, Medema Jan Paul SPI-CI and SPI-6 cooperate in the protection from effector cell-mediated cytotoxicity Blood 2005;105 (3):1153-1161 [PubMed]

2004

• Edel Michael J., Shvarts Avi, Medema Jan Paul, Bernards René An in vivo functional genetic screen reveals a role for the TRK-T3 oncogene in tumor progression Oncogene 2004;23 (29):4959-4965 [PubMed]
• Planelles Lourdes, Carvalho-Pinto Carla E., Hardenberg Gijs, Smaniotto Salette, Savino Wilson, Gómez-Caro Ruth, Alvarez-Mon Melchor, de Jong Joan, Eldering Eric, Martínez-A Carlos, Medema Jan Paul, Hahne Michael APRIL promotes B-1 cell-associated neoplasm Cancer cell 2004;6 (4):399-408 [PubMed]
• Vermijlen David, Luo Dianzhong, Froelich Christopher J., Medema Jan P., Kummer Jean A., Willems Erik, Braet Filip, Wisse Eddie Pit cells exclusively kill P815 tumor cells by the perforin/granzyme pathway Comparative hepatology 2004;3 (Suppl. 1):S58 [PubMed]

2003

• de Bruin E. C., Meersma D., de Wilde J., den Otter I., Schipper E. M., Medema J. P., Peltenburg L. T. C. A serine protease is involved in the initiation of DNA damage-induced apoptosis Cell death and differentiation 2003;10 (10):1204-1212 [PubMed]
• Tolboom Tanja C. A., Medema Jan Paul, van Gaalen Floris A., Pieterman Elsbet, Huizinga Tom W. J., Toes René E. M. Fibroblast-like synoviocytes from rheumatoid arthritis patients express less FLICE-inhibitory protein than fibroblast-like synoviocytes from trauma patients: comment on the article by Schedel et al Arthritis and rheumatism 2003;48 (3):858-9; author reply 859 [PubMed]
• Velthuis Jurjen H. L., de Bont Hans J. G. M., Medema Jan-Paul, Kuppen Peter J. K., Mulder Gerard J., Nagelkerke J. Fred Interleukin-2 activated NK cells do not use the CD95L- and TRAIL-pathways in the rapid induction of apoptosis of rat colon carcinoma CC531s cells Immunobiology 2003;207 (2):115-127 [PubMed]
• Medema J. P. Receptors to die for Cell death and differentiation 2003;10 (1):1-3
• Medema J. P., Planelles-Carazo L., Hardenberg G., Hahne M. The uncertain glory of APRIL Cell death and differentiation 2003;10 (10):1121-1125 [PubMed]
• Kolfschoten Geertruida M., Pradet-Balade Bérengère, Hahne Michael, Medema Jan Paul TWE-PRIL; a fusion protein of TWEAK and APRIL Biochemical pharmacology 2003;66 (8):1427-1432 [PubMed]

2002

• Pradet-Balade B., Medema J. P., López-Fraga M., Lozano J. C., Kolfschoten G. M., Picard A., Martínez-A C., Garcia-Sanz J. A., Hahne M. An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein EMBO journal 2002;21 (21):5711-5720 [PubMed]
• Stein Jens V., López-Fraga Marta, Elustondo Fernando A., Carvalho-Pinto Carla E., Rodríguez Dolores, Gómez-Caro Ruth, de Jong Joan, Martínez-A Carlos, Medema Jan Paul, Hahne Michael APRIL modulates B and T cell immunity Journal of clinical investigation 2002;109 (12):1587-1598 [PubMed]
• van Mierlo Geertje J. D., den Boer Annemieke Th, Medema Jan Paul, van der Voort Ellen I. H., Fransen Marieke F., Offringa Rienk, Melief Cornelis J. M., Toes Rene E. M. CD40 stimulation leads to effective therapy of CD40(-) tumors through induction of strong systemic cytotoxic T lymphocyte immunity Proceedings of the National Academy of Sciences of the United States of America 2002;99 (8):5561-5566 [PubMed]
• Medema Jan Paul, Medema René H. Chromosome instability: lessons from HIV Nature cell biology 2002;4 (8):E191-E193 [PubMed]
• Vermijlen David, Luo Dianzhong, Froelich Christopher J., Medema Jan Paul, Kummer Jean Alain, Willems Erik, Braet Filip, Wisse Eddie Hepatic natural killer cells exclusively kill splenic/blood natural killer-resistant tumor cells by the perforin/granzyme pathway Journal of leukocyte biology 2002;72 (4):668-676 [PubMed]
• Medema J. P., Simon A. K. Suicide determines self Cell death and differentiation 2002;9 (4):364-366 [PubMed]

2001

• Medema J. P., de Jong J., Peltenburg L. T., Verdegaal E. M., Gorter A., Bres S. A., Franken K. L., Hahne M., Albar J. P., Melief C. J., Offringa R. Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors Proceedings of the National Academy of Sciences of the United States of America 2001;98 (20):11515-11520 [PubMed]
• Melief Cornelis J.M., Schuurhuis Danita, Diehl Linda, Medema Jan Paul, Ossendorp Ferry, Mittler Robert S., Toes René, Offringa Rienk CD4+ and DC requirements for optimal CD8+ CTL induction against tumors European journal of cancer (Oxford, England 2001;37 (SUPPL. 1):S5
• van Eijk M., Medema J. P., de Groot C. Cutting edge: cellular Fas-associated death domain-like IL-1-converting enzyme-inhibitory protein protects germinal center B cells from apoptosis during germinal center reactions Journal of immunology (Baltimore, Md. 2001;166 (11):6473-6476 [PubMed]
• van Elsas A., Sutmuller R. P., Hurwitz A. A., Ziskin J., Villasenor J., Medema J. P., Overwijk W. W., Restifo N. P., Melief C. J., Offringa R., Allison J. P. Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy Journal of experimental medicine 2001;194 (4):481-489 [PubMed]
• Medema J. P., Schuurhuis D. H., Rea D., van Tongeren J., de Jong J., Bres S. A., Laban S., Toes R. E., Toebes M., Schumacher T. N., Bladergroen B. A., Ossendorp F., Kummer J. A., Melief C. J., Offringa R. Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: differential modulation by T helper type 1 and type 2 cells Journal of experimental medicine 2001;194 (5):657-667 [PubMed]
• Schurmans L. R., Diehl L., den Boer A. T., Sutmuller R. P., Boonman Z. F., Medema J. P., van der Voort E. I., Laman J., Melief C. J., Jager M. J., Toes R. E. Rejection of intraocular tumors by CD4(+) T cells without induction of phthisis Journal of immunology (Baltimore, Md. 2001;167 (10):5832-5837 [PubMed]

2000

• Melief C. J., Toes R. E., Medema J. P., van der Burg S. H., Ossendorp F., Offringa R. Strategies for immunotherapy of cancer Advances in immunology 2000;75:235-282 [PubMed]

1999

• Medema J. P. Apoptosis. Life and death in a FLASH Nature 1999;398 (6730):756-757 [PubMed]
• Medema J. P., de Jong J., van Hall T., Melief C. J., Offringa R. Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein Journal of experimental medicine 1999;190 (7):1033-1038 [PubMed]
• Sark M. W., Borgstein A. M., Medema J. P., van de Putte P., Backendorf C. Opposite effects of Ras or PKC activation on the expression of the SPRR2A keratinocyte terminal differentiation marker Experimental cell research 1999;250 (2):475-484 [PubMed]
• Medema J. P., Borst J. T cell signaling: a decision of life and death Human immunology 1999;60 (5):403-411 [PubMed]
• Peter M. E., Scaffidi C., Medema J. P., Kischkel F., Krammer P. H. The death receptors Results and problems in cell differentiation 1999;23:25-63 [PubMed]
• Medema J. P., Hahne M., Walczak H., Laurenzi V. D. The First European Workshop on Cell Death: (Death on the Rocks) held at Gran Sasso, Italy, 21 - 25 October 1998. Rocking cell death Cell death and differentiation 1999;6 (3):297-300 [PubMed]

1998

• Medema J. P., Scaffidi C., Krammer P. H., Peter M. E. Bcl-xL acts downstream of caspase-8 activation by the CD95 death-inducing signaling complex Journal of biological chemistry 1998;273 (6):3388-3393 [PubMed]
• de Laurenzi V., Hahne M., Walczak H., Medema J. P. We aim to refresh science, not to rebel Nature 1998;393 (6682):206 [PubMed]

1997

• Medema J. P., Toes R. E., Scaffidi C., Zheng T. S., Flavell R. A., Melief C. J., Peter M. E., Offringa R., Krammer P. H. Cleavage of FLICE (caspase-8) by granzyme B during cytotoxic T lymphocyte-induced apoptosis European journal of immunology 1997;27 (12):3492-3498 [PubMed]
• Peter M. E., Medema J. P., Krammer P. H. Does the Caenorhabditis elegans protein CED-4 contain a region of homology to the mammalian death effector domain? Cell death and differentiation 1997;4 (7):523-525 [PubMed]
• Medema J. P., Scaffidi C., Kischkel F. C., Shevchenko A., Mann M., Krammer P. H., Peter M. E. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC) EMBO journal 1997;16 (10):2794-2804 [PubMed]
• Kischkel F. C., Peter M. E., Medema J. P., Scaffidi C., Scheuerpflug C., Debatin K. M., Krammer P. H. FLICE is involved in regulation of activation-induced cell death (AICD) of peripheral T cells Immunobiology 1997;197 (2-4):173
• Scaffidi C., Medema J. P., Krammer P. H., Peter M. E. FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b Journal of biological chemistry 1997;272 (43):26953-26958 [PubMed]
• Peter M. E., Kischkel F. C., Scheuerpflug C. G., Medema J. P., Debatin K. M., Krammer P. H. Resistance of cultured peripheral T cells towards activation-induced cell death involves a lack of recruitment of FLICE (MACH/caspase 8) to the CD95 death-inducing signaling complex European journal of immunology 1997;27 (5):1207-1212 [PubMed]
• Scaffidi C., Medema J. P., Kischkel F. C., Krammer P. H., Peter M. E. Two FLICE isoforms (Caspase 8/a and Caspase 8/b) are both recruited and activated by the CD95 death inducing signaling complex (DISC) Immunobiology 1997;197 (2-4):178

1996

• Medema J. P., Pronk G. J., de Vries-Smits A. M., Clark R., McCormick F., Bos J. L. Insulin-induced tyrosine phosphorylation of a M(r) 70,000 protein revealed by association with the Src homology 2 (SH2) and SH3 domains of p120GAP and Grb2 Cell growth & differentiation 1996;7 (4):543-550 [PubMed]

1995

• Medema J. P., de Vries-Smits A. M., Bos J. L. Calcium induces tyrosine phosphorylation of a novel p120GAP-associated protein of 65 kDa Oncogene 1995;11 (4):757-762 [PubMed]
• van Weering D. H., Medema J. P., van Puijenbroek A., Burgering B. M., Baas P. D., Bos J. L. Ret receptor tyrosine kinase activates extracellular signal-regulated kinase 2 in SK-N-MC cells Oncogene 1995;11 (11):2207-2214 [PubMed]
• de Vries-Smits A. M., Pronk G. J., Medema J. P., Burgering B. M., Bos J. L. Shc associates with an unphosphorylated form of the p21ras guanine nucleotide exchange factor mSOS Oncogene 1995;10 (5):919-925 [PubMed]

1994

• Medema J. P., Sark M. W., Backendorf C., Bos J. L. Calcium inhibits epidermal growth factor-induced activation of p21ras in human primary keratinocytes Molecular and cellular biology 1994;14 (11):7078-7085 [PubMed]
• Medema J. P., Streilein J. W., Graser R., Vincek V. Nucleotide sequence of the tumor necrosis factor: a gene in seven different inbred mouse strains Immunogenetics 1994;40 (3):243-244 [PubMed]
• Streilein J. W., Taylor J. R., Vincek V., Kurimoto I., Richardson J., Tie C., Medema J. P., Golomb C. Relationship between ultraviolet radiation-induced immunosuppression and carcinogenesis Journal of investigative dermatology 1994;103 (5 Suppl):107S-111S [PubMed]

1993

• Burgering B. M., Pronk G. J., Medema J. P., van der Voorn L., de Vries Smits A. M., van Weeren P. C., Bos J. L. Role of p21ras in growth factor signal transduction Biochemical Society transactions 1993;21 (4):888-894 [PubMed]
• Vincek V., Kurimoto I., Medema J. P., Prieto E., Streilein J. W. Tumor necrosis factor alpha polymorphism correlates with deleterious effects of ultraviolet B light on cutaneous immunity Cancer research 1993;53 (4):728-732 [PubMed]