Prof. N. Zelcer PhD publications

2020

• Loregger Anke, Raaben Matthijs, Nieuwenhuis Joppe, Tan Josephine M. E., Jae Lucas T., van den Hengel Lisa G., Hendrix Sebastian, van den Berg Marlene, Scheij Saskia, Song Ji-Ying, Huijbers Ivo J., Kroese Lona J., Ottenhoff Roelof, van Weeghel Michel, van de Sluis Bart, Brummelkamp Thijn, Zelcer Noam Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism Nature communications 2020;11 (1) [PubMed]
• van Loon Nienke M. IDOL & MARCH6: E3 ligases in search for physiological meaning 2020. 218p. ISBN 9789463809290. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Zelcer Noam; Co-supervisor: de Vries Carlie J. M.)
• van Loon Nienke M., van Wouw Suzanne A. E., Ottenhoff Roelof, Nelson Jessica K., Kingma Jenina, Scheij Saskia, Moeton Martina, Zelcer Noam Regulation of intestinal LDLR by the LXR-IDOL axis Atherosclerosis 2020;315:1-9 [PubMed]
• Bogie Jeroen F. J., Grajchen Elien, Wouters Elien, Corrales Aida Garcia, Dierckx Tess, Vanherle Sam, Mailleux Jo, Gervois Pascal, Wolfs Esther, Dehairs Jonas, van Broeckhoven Jana, Bowman Andrew P., Lambrichts Ivo, Gustafsson Jan-Åke, Remaley Alan T., Mulder Monique, Swinnen Johannes V., Haidar Mansour, Ellis Shane R., Ntambi James M., Zelcer Noam, Hendriks Jerome J. A. Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain Journal of experimental medicine 2020;217 (5) [PubMed]
• Martinelli Luca, Adamopoulos Athanassios, Johansson Patrik, Wan Paul T., Gunnarsson Jenny, Guo Hongwei, Boyd Helen, Zelcer Noam, Sixma Titia K. Structural analysis of the LDL receptor-interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site Journal of biological chemistry 2020;295 (39):13570-13583 [PubMed]
• Tan Josephine Mathilde Elisabeth, van der Stoel Miesje Maxime, van den Berg Marlene, van Loon Nienke Marlies, Moeton Martina, Scholl Edwin, van der Wel Nicole Neeltje, Kovačević Igor, Hordijk Peter Lodewijk, Loregger Anke, Huveneers Stephan, Zelcer Noam The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting Cell reports 2020;32 (5) [PubMed]

2019

• Avagliano Trezza Rossella A matter of perspective: The multifaceted role of UBE3A in Angelman syndrome development 2019. 223p. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Distel B. , Zelcer N.; Co-supervisor: Aerts J. M. F. G.)
• Tan Josephine M. E., Cook Emma C. L., van den Berg Marlene, Scheij Saskia, Zelcer Noam, Loregger Anke Differential use of E2 ubiquitin conjugating enzymes for regulated degradation of the rate-limiting enzymes HMGCR and SQLE in cholesterol biosynthesis Atherosclerosis 2019;281:137-142 [PubMed]
• Pronk Manon C. A., Majolée Jisca, Loregger Anke, van Bezu Jan S. M., Zelcer Noam, Hordijk Peter L., Kovačević Igor FBXW7 regulates endothelial barrier function by suppression of the cholesterol synthesis pathway and prenylation of RhoB Molecular biology of the cell 2019;30 (5):607-621 [PubMed]
• Cook Emma C. L. Fine-tuning protein recycling to control cholesterol homeostasis 2019. 208p. ISBN 9789461829566. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Zelcer N. , de Vries C. J. M.; Co-supervisor: Loregger A.)
• Oteng Antwi-Boasiako, Loregger Anke, van Weeghel Michel, Zelcer Noam, Kersten Sander Industrial Trans Fatty Acids Stimulate SREBP2-Mediated Cholesterogenesis and Promote Non-Alcoholic Fatty Liver Disease Molecular nutrition & food research 2019 [PubMed]
• van den Boogert Marjolein A. W., Larsen Lars E., Ali Lubna, Kuil Sacha D., Chong Patrick L. W., Loregger Anke, Kroon Jeffrey, Schnitzler Johan G., Schimmel Alinda W. M., Peter Jorge, Levels Johannes H. M., Steenbergen Gerry, Morava Eva, Dallinga-Thie Geesje M., Wevers Ron A., Kuivenhoven Jan Albert, Hand Nicholas J., Zelcer Noam, Rader Daniel J., Stroes Erik S. G., Lefeber Dirk J., Holleboom Adriaan G. N-Glycosylation Defects in Humans Lower Low-Density Lipoprotein Cholesterol Through Increased Low-Density Lipoprotein Receptor Expression Circulation 2019;140 (4):280-292 [PubMed]
• van Loon Nienke M., Lindholm Dan, Zelcer Noam The E3 ubiquitin ligase inducible degrader of the LDL receptor/myosin light chain interacting protein in health and disease Current opinion in lipidology 2019;30 (3):192-197 [PubMed]

2018

• van Loon Nienke M., Rensen Patrick C. N., Zelcer Noam IDOL in metabolic, neurodegenerative and cardiovascular disease Aging 2018;10 (11):3042-3043
• van Loon Nienke M., Ottenhoff Roelof, Kooijman Sander, Moeton Martina, Scheij Saskia, Roscam Abbing Reinout L. P., Gijbels Marion J. J., Levels Johannes H. M., Sorrentino Vincenzo, Berbée Jimmy F. P., Rensen Patrick C. N., Zelcer Noam Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice Arteriosclerosis, thrombosis, and vascular biology 2018;38 (8):1785-1795 [PubMed]
• Koenis Duco Steven, Medzikovic Lejla, van Loenen Pieter Bas, van Weeghel Michel, Huveneers Stephan, Vos Mariska, Evers-van Gogh Ingrid Johanna, van den Bossche Jan, Speijer Dave, Kim Yongsoo, Wessels Lodewyk, Zelcer Noam, Zwart Wilbert, Kalkhoven Eric, de Vries Carlie Jacoba Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism Cell reports 2018;24 (8):2127-2140.e7 [PubMed]
• Koenis Duco S. Nuclear receptors and their co-factors in hematological and inflammation-driven disorders 2018. ISBN 9789463750202. [UvA Dissertations Online] University of Amsterdam. (Supervisors: de Vries C. J. M., Zelcer N.; Co-supervisors: de Waard V., Huveneers S.)
• Ren Liwei, Sun Yuan, Lu Hong, Ye Dien, Han Lijuan, Wang Na, Daugherty Alan, Li Furong, Wang Miaomiao, Su Fengting, Tao Wenjun, Sun Jie, Zelcer Noam, Mullick Adam E., Danser Ah J., Jiang Yizhou, He Yongcheng, Ruan Xiongzhong, Lu Xifeng (Pro)renin Receptor Inhibition Reprograms Hepatic Lipid Metabolism and Protects Mice from Diet-Induced Obesity and Hepatosteatosis Circulation research 2018;122 (5):730-741 [PubMed]
• Alioui Anthony, Dufour Julie, Leoni Valerio, Loregger Anke, Moeton Martina, Iuliano Luigi, Zerbinati Chiara, Septier Amandine, Val Pierre, Fouache Allan, Russo Vincenzo, Volle David H., Lobaccaro Jean-Marc A., Zelcer Noam, Baron Silvère Retraction: Liver X receptors constrain tumor development and metastasis dissemination in PTEN-deficient prostate cancer (Nature Communications DOI: 10.1038/s41467-017-00508-5) Nature communications 2018;9 (1) [PubMed]

2017

• Loregger Anke, Nelson Jessica K., Zelcer Noam Assaying Low-Density-Lipoprotein (LDL) Uptake into Cells Methods in molecular biology (Clifton, N.J.) 2017;1583:53-63 [PubMed]
• Nelson Jessica Kristine, Koenis Duco Steven, Scheij Saskia, Cook Emma Clare Laura, Moeton Martina, Santos Ana, Lobaccaro Jean-Marc Adolphe, Baron Silvere, Zelcer Noam EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux Arteriosclerosis, thrombosis, and vascular biology 2017;37 (3):423-432 [PubMed]
• Loregger Anke, Raaben Matthijs, Tan Josephine, Scheij Saskia, Moeton Martina, van den Berg Marlene, Gelberg-Etel Hila, Stickel Elmer, Roitelman Joseph, Brummelkamp Thijn, Zelcer Noam Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis Arteriosclerosis, thrombosis, and vascular biology 2017;37 (11):2064-2074 [PubMed]
• Cook Emma C. L., Nelson Jessica K., Sorrentino Vincenzo, Koenis Duco, Moeton Martina, Scheij Saskia, Ottenhoff Roelof, Bleijlevens Boris, Loregger Anke, Zelcer Noam Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene PLoS ONE 2017;12 (2) [PubMed]
• Alioui Anthony, Dufour Julie, Leoni Valerio, Loregger Anke, Moeton Martina, Iuliano Luigi, Zerbinati Chiara, Septier Amandine, Val Pierre, Fouache Allan, Russo Vincenzo, Volle David H., Lobaccaro Jean-Marc A., Zelcer Noam, Baron Silvère Liver X receptors constrain tumor development and metastasis dissemination in PTEN-deficient prostate cancer Nature communications 2017;8 (1) [PubMed]
• Hakonen Johanna E., Sorrentino Vincenzo, Avagliano Trezza Rossella, de Wissel Marit B., van den Berg Marlene, Bleijlevens Boris, van Ruissen Fred, Distel Ben, Baas Frank, Zelcer Noam, Weterman Marian A. J. LRSAM1-mediated ubiquitylation is disrupted in axonal Charcot-Marie-Tooth disease 2P Human molecular genetics 2017;26 (11):2034-2041 [PubMed]

2016

• Tol Marc J., Ottenhoff Roelof, van Eijk Marco, Zelcer Noam, Aten Jan, Houten Sander M., Geerts Dirk, van Roomen Cindy, Bierlaagh Marlou C., Scheij Saskia, Hoeksema Marten A., Aerts Johannes M., Bogan Jonathan S., Dorn Gerald W., Argmann Carmen A., Verhoeven Arthur J. A PPARγ-Bnip3 Axis Couples Adipose Mitochondrial Fusion-Fission Balance to Systemic Insulin Sensitivity Diabetes 2016;65 (9):2591-2605 [PubMed]
• Tol Marc J. P. M. Deregulation of lysosomal and mitochondrial dynamics in obesity 2016. 169p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Verhoeven A. J.; Co-supervisors: Zelcer N., van Eijk M. C.)
• Nelson Jessica Kristine, Cook Emma Clare Laura, Loregger Anke, Hoeksema Marten Anne, Scheij Saskia, Kovacevic Igor, Hordijk Peter Lodewijk, Ovaa Huib, Zelcer Noam Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake Journal of biological chemistry 2016;291 (9):4813-4825 [PubMed]
• Lu Xifeng, Meima Marcel E., Nelson Jessica K., Sorrentino Vincenzo, Loregger Anke, Scheij Saskia, Dekkers Dick H. W., Mulder Monique T., Demmers Jeroen A. A., M-Dallinga-Thie Geesje, Zelcer Noam, Danser A. H. Jan Identification of the (Pro)renin Receptor as a Novel Regulator of Low-Density Lipoprotein Metabolism Circulation research 2016;118 (2):222-229 [PubMed]
• van Loon Nienke Marlies, Zelcer Noam Idolizing the clearance of Amyloid-β by microglia Annals of translational medicine 2016;4 (24):536 [PubMed]
• Nelson Jessica K. Scratching the surface: Regulation of cell surface receptors in cholesterol metabolism 2016. 239p. ISBN 9789461699435. [UvA Dissertations Online] University of Amsterdam. (Supervisors: de Vries C. J. M., Zelcer N.)
• Nelson Jessica Kristine, Sorrentino Vincenzo, Avagliano Trezza Rossella, Heride Claire, Urbe Sylvie, Distel Ben, Zelcer Noam The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL Circulation research 2016;118 (3):410-419 [PubMed]

2015

• Loregger Anke, Cook Emma Claire Laura, Nelson Jessica Kristin, Moeton Martina, Sharpe Laura Jane, Engberg Susanna, Karimova Madina, Lambert Gilles, Brown Andrew John, Zelcer Noam A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes Molecular and cellular biology 2015;36 (2):285-294 [PubMed]
• de Boussac Hugues, Maqdasy Salwan, Trousson Amalia, Zelcer Noam, Volle David H., Lobaccaro Jean-Marc A., Baron Silvère Enolase is regulated by Liver X Receptors Steroids 2015;99 (Part B):266-271 [PubMed]
• Kurakula Kondababu, Sommer Daniela, Sokolovic Milka, Moerland Perry D., Scheij Saskia, van Loenen Pieter B., Koenis Duco S., Zelcer Noam, van Tiel Claudia M., de Vries Carlie J. M. LIM-Only Protein FHL2 Is a Positive Regulator of Liver X Receptors in Smooth Muscle Cells Involved in Lipid Homeostasis Molecular and cellular biology 2015;35 (1):52-62 [PubMed]

2014

• Zelcer Noam, Westerterp Marit Adeno-associated viruses as a method to induce atherosclerosis in mice and hamsters Circulation research 2014;114 (11):1672-1674 [PubMed]
• Kizhakkedath Praseetha, Loregger Anke, John Anne, Bleijlevens Boris, Al-Blooshi Ali S., Al-Hosani Ahmed H., Al-Nuaimi Ahmed M., Al-Gazali Lihadh, Zelcer Noam, Ali Bassam R. Impaired trafficking of the very low density lipoprotein receptor caused by missense mutations associated with dysequilibrium syndrome BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 2014;1843 (12):2871-2877 [PubMed]
• Fouchier Sigrid W., Dallinga-Thie Geesje M., Meijers Joost C. M., Zelcer Noam, Kastelein John J. P., Defesche Joep C., Hovingh G. Kees Mutations in STAP1 are associated with autosomal dominant hypercholesterolemia Circulation research 2014;115 (6):552-555 [PubMed]
• Sorrentino Vincenzo Regulation of cholesterol metabolism: An IDOL-dependent pathway to degrade the LDL-receptor 2014. 130p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Aerts J. M. F. G.; Co-supervisor: Zelcer N.)
• Zelcer Noam, Sharpe Laura J., Loregger Anke, Kristiana Ika, Cook Emma C. L., Phan Lisa, Stevenson Julian, Brown Andrew J. The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway Molecular and cellular biology 2014;34 (7):1262-1270 [PubMed]
• Sharpe Laura J., Cook Emma C. L., Zelcer Noam, Brown Andrew J. The UPS and downs of cholesterol homeostasis Trends in biochemical sciences 2014;39 (11):527-535 [PubMed]

2013

• Sorrentino Vincenzo, Fouchier Sigrid W., Motazacker Mohammad M., Nelson Jessica K., Defesche Joep C., Dallinga-Thie Geesje M., Kastelein John J. P., Kees Hovingh G., Zelcer Noam Identification of a loss-of-function inducible degrader of the low-density lipoprotein receptor variant in individuals with low circulating low-density lipoprotein European heart journal 2013;34 (17):1292-1297 [PubMed]
• Bogie Jeroen F. J., Jorissen Winde, Mailleux Jo, Nijland Philip G., Zelcer Noam, Vanmierlo Tim, van Horssen Jack, Stinissen Piet, Hellings Niels, Hendriks Jerome J. A. Myelin alters the inflammatory phenotype of macrophages by activating PPARs Acta neuropathologica communications 2013;1 (1):43-(13 p.) [PubMed]
• Pietiäinen Vilja, Vassilev Boris, Blom Tomas, Wang Wei, Nelson Jessica, Bittman Robert, Bäck Nils, Zelcer Noam, Ikonen Elina NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation Journal of cell science 2013;126 (Part 17):3961-3971 [PubMed]
• Sorrentino Vincenzo, Nelson Jessica K., Maspero Elena, Marques André R. A., Scheer Lilith, Polo Simona, Zelcer Noam The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation Journal of lipid research 2013;54 (8):2174-2184 [PubMed]

2012

• Motazacker Mohammad Mahdi, Pirruccello James, Huijgen Roeland, Do Ron, Gabriel Stacey, Peter Jorge, Kuivenhoven Jan Albert, Defesche Joep C., Kastelein John J. P., Hovingh G. Kees, Zelcer Noam, Kathiresan Sekar, Fouchier Sigrid W. Advances in genetics show the need for extending screening strategies for autosomal dominant hypercholesterolaemia European heart journal 2012;33 (11):1360-1366 [PubMed]
• Weterman Marian A. J., Sorrentino Vincenzo, Kasher Paul R., Jakobs Marja E., van Engelen Baziel G. M., Fluiter Kees, de Wissel Marit B., Sizarov Aleksander, Nürnberg Gudrun, Nürnberg Peter, Zelcer Noam, Schelhaas H. Jurgen, Baas Frank A frameshift mutation in LRSAM1 is responsible for a dominant hereditary polyneuropathy Human molecular genetics 2012;21 (2):358-370 [PubMed]
• Do Hai Thi, Tselykh Timofey V., Mäkelä Johanna, Ho Tho Huu, Olkkonen Vesa M., Bornhauser Beat C., Korhonen Laura, Zelcer Noam, Lindholm Dan Fibroblast Growth Factor-21 (FGF21) Regulates Low-density Lipoprotein Receptor (LDLR) Levels in Cells via the E3-ubiquitin Ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting Saposin-like Protein (Msap) Journal of biological chemistry 2012;287 (16):12602-12611 [PubMed]
• Sorrentino Vincenzo, Zelcer Noam Post-transcriptional regulation of lipoprotein receptors by the E3-ubiquitin ligase inducible degrader of the low-density lipoprotein receptor Current opinion in lipidology 2012;23 (3):213-219 [PubMed]

2011

• Sorrentino Vincenzo, Scheer Lilith, Santos Ana, Reits Eric, Bleijlevens Boris, Zelcer Noam Distinct functional domains contribute to degradation of the low density lipoprotein receptor (LDLR) by the E3 ubiquitin ligase inducible Degrader of the LDLR (IDOL) Journal of biological chemistry 2011;286 (34):30190-30199 [PubMed]
• Scotti Elena, Hong Cynthia, Yoshinaga Yuko, Tu Yiping, Hu Yan, Zelcer Noam, Boyadjian Rima, de Jong Pieter J., Young Stephen G., Fong Loren G., Tontonoz Peter Targeted disruption of the Idol gene alters cellular regulation of the LDLR by sterols and LXR agonists Molecular and cellular biology 2011;31 (9):1885-1893 [PubMed]
• Weissglas-Volkov Daphna, Calkin Anna C., Tusie-Luna Teresa, Sinsheimer Janet S., Zelcer Noam, Riba Laura, Tino Ana Maria Vargas, Ordoñez-Sánchez Maria Luisa, Cruz-Bautista Ivette, Aguilar-Salinas Carlos A., Tontonoz Peter, Pajukanta Päivi The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans Journal of clinical investigation 2011;121 (8):3062-3071 [PubMed]

2010

• Hong Cynthia, Duit Sarah, Jalonen Pilvi, Out Ruud, Scheer Lilith, Sorrentino Vincenzo, Boyadjian Rima, Rodenburg Kees C. W., Foley Edan, Korhonen Laura, Lindholm Dan, Nimpf Johannes, van Berkel Theo J. C., Tontonoz Peter, Zelcer Noam The E3 Ubiquitin Ligase IDOL Induces the Degradation of the Low Density Lipoprotein Receptor Family Members VLDLR and ApoER2 Journal of biological chemistry 2010;285 (26):19720-19726 [PubMed]

2009

• A-Gonzalez Noelia, Bensinger Steven J., Hong Cynthia, Beceiro Susana, Bradley Michelle N., Zelcer Noam, Deniz Jose, Ramirez Cristina, Díaz Mercedes, Gallardo German, de Galarreta Carlos Ruiz, Salazar Jon, Lopez Felix, Edwards Peter, Parks John, Andujar Miguel, Tontonoz Peter, Castrillo Antonio Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR Immunity 2009;31 (2):245-258 [PubMed]
• Zelcer Noam, Hong Cynthia, Boyadjian Rima, Tontonoz Peter LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor Science 2009;325 (5936):100-104 [PubMed]

2008

• Jiang Qingguang, Lee C. Y. Daniel, Mandrekar Shweta, Wilkinson Brandy, Cramer Paige, Zelcer Noam, Mann Karen, Lamb Bruce, Willson Timothy M., Collins Jon L., Richardson Jill C., Smith Jonathan D., Comery Thomas A., Riddell David, Holtzman David M., Tontonoz Peter, Landreth Gary E. ApoE promotes the proteolytic degradation of Abeta Neuron 2008;58 (5):681-693 [PubMed]
• Bensinger Steven J., Bradley Michelle N., Joseph Sean B., Zelcer Noam, Janssen Edith M., Hausner Mary Ann, Shih Roger, Parks John S., Edwards Peter A., Jamieson Beth D., Tontonoz Peter LXR signaling couples sterol metabolism to proliferation in the acquired immune response Cell 2008;134 (1):97-111 [PubMed]

2007

• Zelcer Noam, Khanlou Negar, Clare Ryan, Jiang Qingguang, Reed-Geaghan Erin G., Landreth Gary E., Vinters Harry V., Tontonoz Peter Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors Proceedings of the National Academy of Sciences of the United States of America 2007;104 (25):10601-10606 [PubMed]
• van de Wetering Koen, Zelcer Noam, Kuil Annemieke, Feddema Wouter, Hillebrand Michel, Vlaming Maria L. H., Schinkel Alfred H., Beijnen Jos H., Borst Piet Multidrug resistance proteins 2 and 3 provide alternative routes for hepatic excretion of morphine-glucuronides Molecular pharmacology 2007;72 (2):387-394 [PubMed]

2006

• Zelcer Noam, Tontonoz Peter Liver X receptors as integrators of metabolic and inflammatory signaling Journal of clinical investigation 2006;116 (3):607-614 [PubMed]
• Zelcer Noam, van de Wetering Koen, de Waart Rudi, Scheffer George L., Marschall Hanns-Ulrich, Wielinga Peter R., Kuil Annemieke, Kunne Cindy, Smith Alexander, van der Valk Martin, Wijnholds Jan, Elferink Ronald Oude, Borst Piet Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides Journal of hepatology 2006;44 (4):768-775 [PubMed]
• Borst P., Zelcer N., van de Wetering K. MRP2 and 3 in health and disease Cancer letters 2006;234 (1):51-61 [PubMed]
• Borst P., Zelcer N., van de Wetering K., Poolman B. On the putative co-transport of drugs by multidrug resistance proteins FEBS letters 2006;580 (4):1085-1093 [PubMed]

2005

• Manautou José E., de Waart Dirk R., Kunne Cindy, Zelcer Noam, Goedken Michael, Borst Piet, Elferink Ronald Oude Altered disposition of acetaminophen in mice with a disruption of the Mrp3 gene Hepatology (Baltimore, Md.) 2005;42 (5):1091-1098 [PubMed]
• Pichler Andrea, Zelcer Noam, Prior Julie L., Kuil Annemieke J., Piwnica-Worms David In vivo RNA interference-mediated ablation of MDR1 P-glycoprotein Clinical cancer research 2005;11 (12):4487-4494 [PubMed]
• Zelcer Noam, van de Wetering Koen, Hillebrand Michel, Sarton Elise, Kuil Annemieke, Wielinga Peter R., Tephly Thomas, Dahan Albert, Beijnen Jos H., Borst Piet Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception Proceedings of the National Academy of Sciences of the United States of America 2005;102 (20):7274-7279 [PubMed]
• Zelcer Noam, Tontonoz Peter SUMOylation and PPARgamma: wrestling with inflammatory signaling Cell metabolism 2005;2 (5):273-275 [PubMed]
• Wielinga Peter, Hooijberg Jan Hendrik, Gunnarsdottir Sjofn, Kathmann Ietje, Reid Glen, Zelcer Noam, van der Born Kasper, de Haas Marcel, van der Heijden Ingrid, Kaspers Gertjan, Wijnholds Jan, Jansen Gerrit, Peters Godefridus, Borst Piet The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates Cancer research 2005;65 (10):4425-4430 [PubMed]

2004

• Cummings Jeffrey, Zelcer Noam, Allen John D., Yao Denggao, Boyd Gary, Maliepaard Mark, Friedberg Thomas H., Smyth John F., Jodrell Duncan I. Glucuronidation as a mechanism of intrinsic drug resistance in colon cancer cells: contribution of drug transport proteins Biochemical pharmacology 2004;67 (1):31-39 [PubMed]
• Assem Mahfoud, Schuetz Erin G., Leggas Markos, Sun Daxi, Yasuda Kazuto, Reid Glen, Zelcer Noam, Adachi Masashi, Strom Stephen, Evans Ronald M., Moore David D., Borst Piet, Schuetz John D. Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice Journal of biological chemistry 2004;279 (21):22250-22257 [PubMed]
• Breedveld Pauline, Zelcer Noam, Pluim Dick, Sönmezer Ozgür, Tibben Matthijs M., Beijnen Jos H., Schinkel Alfred H., van Tellingen Olaf, Borst Piet, Schellens Jan H. M. Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions Cancer research 2004;64 (16):5804-5811 [PubMed]
• Borst P., Balzarini J., Ono N., Reid G., de Vries H., Wielinga P., Wijnholds J., Zelcer N. The potential impact of drug transporters on nucleoside-analog-based antiviral chemotherapy Antiviral research 2004;62 (1):1-7 [PubMed]

2003

• Reid Glen, Wielinga Peter, Zelcer Noam, de Haas Marcel, van Deemter Liesbeth, Wijnholds Jan, Balzarini Jan, Borst Piet Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5 Molecular pharmacology 2003;63 (5):1094-1103 [PubMed]
• Zelcer Noam, Huisman Maarten T., Reid Glen, Wielinga Peter, Breedveld Pauline, Kuil Annemieke, Knipscheer Puck, Schellens Jan H. M., Schinkel Alfred H., Borst Piet Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2) Journal of biological chemistry 2003;278 (26):23538-23544 [PubMed]
• Zelcer N. MRP2-4, from drug resistance to physiology 2003. 132p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Borst P.)
• Zelcer Noam, Reid Glen, Wielinga Peter, Kuil Annemieke, van der Heijden Ingrid, Schuetz John D., Borst Piet Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4) Biochemical journal 2003;371 (Part 2):361-367 [PubMed]
• Reid Glen, Wielinga Peter, Zelcer Noam, van der Heijden Ingrid, Kuil Annemieke, de Haas Marcel, Wijnholds Jan, Borst Piet The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs Proceedings of the National Academy of Sciences of the United States of America 2003;100 (16):9244-9249 [PubMed]
• Zelcer Noam, Saeki Tohru, Bot Ilse, Kuil Annemieke, Borst Piet Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter Biochemical journal 2003;369 (Part 1):23-30 [PubMed]

2002

• Burg Danny, Wielinga Peter, Zelcer Noam, Saeki Tohru, Mulder Gerard J., Borst Piet Inhibition of the multidrug resistance protein 1 (MRP1) by peptidomimetic glutathione-conjugate analogs Molecular pharmacology 2002;62 (5):1160-1166 [PubMed]
• Huisman Maarten T., Smit Johan W., Crommentuyn Kristel M. L., Zelcer Noam, Wiltshire Hugh R., Beijnen Jos H., Schinkel Alfred H. Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs AIDS (London, England) 2002;16 (17):2295-2301 [PubMed]

2001

• Zelcer N., Saeki T., Reid G., Beijnen J. H., Borst P. Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3) Journal of biological chemistry 2001;276 (49):46400-46407 [PubMed]

2000

• Borst P., Zelcer N., van Helvoort A. ABC transporters in lipid transport BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 2000;1486 (1):128-144 [PubMed]