Prof. R.A.A. Mathot PhD publications

2021

• Bukkems Laura H., Preijers Tim, van Spengler Max W. F., Leebeek Frank W. G., Cnossen Marjon H., Mathôt Ron A. A. Comparison of the Pharmacokinetic Properties of Extended Half-Life and Recombinant Factor VIII Concentrates by in Silico Simulations Thrombosis and haemostasis 2021 [PubMed]
• de Vroom Suzanne L., van Daalen Frederike V., Zieck Saskia E., Mathôt Ron A. A., van Hest Reinier M., Geerlings Suzanne E. Does dose reduction of renally cleared antibiotics in patients with impaired renal function lead to adequate drug exposure? A systematic review Clinical microbiology and infection 2021 [PubMed]
• Strik Anne S., Löwenberg Mark, Mould Diane R., Berends Sophie E., Ponsioen Cyriel I., van den Brande Jan M. H., Jansen Jeroen M., Hoekman Daniël R., Brandse Johannan F., Duijvestein Marjolijn, Gecse Krisztina B., de Vries Annick, Mathôt Ron A., D’Haens Geert R. Efficacy of dashboard driven dosing of infliximab in inflammatory bowel disease patients; a randomized controlled trial Scandinavian journal of gastroenterology 2021;56 (2):145-154 [PubMed]
• Dreesen Erwin, Berends Sophie, Laharie David, D'Haens Geert, Vermeire S. verine, Gils Ann, Mathôt Ron Modelling of the relationship between infliximab exposure, faecal calprotectin and endoscopic remission in patients with Crohn's disease British journal of clinical pharmacology 2021;87 (1):106-118 [PubMed]
• Preijers Tim, Schütte Lisette M., Kruip Marieke J. H. A., Cnossen Marjon H., Leebeek Frank W. G., van Hest Reinier M., Mathôt Ron A. A. Population Pharmacokinetics of Clotting Factor Concentrates and Desmopressin in Hemophilia Clinical pharmacokinetics 2021;60 (1) [PubMed]
• Sanders Fay R. K., Penning Diederick, Backes Manouk, Dingemans Siem A., van Dieren Susan, Eskes Anne M., Goslings J. Carel, Kloen Peter, Mathôt Ron A. A., Schep Niels W. L., Spijkerman Ingrid J. B., Schepers Tim Wound infection following implant removal of foot, ankle, lower leg or patella; a protocol for a multicenter randomized controlled trial investigating the (cost-)effectiveness of 2 g of prophylactic cefazolin compared to placebo (WIFI-2 trial) BMC surgery 2021;21 (1) [PubMed]

2020

• Bukkems Laura H., Heijdra Jessica M., Mathias Mary, Collins Peter W., Hay Charles R. M., Tait Robert C., Mangles Sarah, Myers Bethan, Evans G., Bailiff Benjamin, Curry Nicola, Payne Jeanette, Austin Steve, Goedhart Tine M. H. J., Leebeek Frank W. G., Meijer Karina, Fijnvandraat Karin, Chowdary Pratima, Mathôt Ron A. A., Cnossen Marjon H. A Novel, Enriched Population Pharmacokinetic Model for Recombinant Factor VIII-Fc Fusion Protein Concentrate in Hemophilia A Patients Thrombosis and haemostasis 2020;120 (5):747-757 [PubMed]
• de Jager Nico C. B., Heijdra Jessica M., Pistorius Marcel, Kruip Marieke J. H. A., Leebeek Frank W. G., Cnossen Marjon H., Mathôt Ron A. A. A Novel Quantitative Method for Analyzing Desmopressin in Human Plasma Using Liquid Chromatography-Tandem Mass Spectrometry Therapeutic drug monitoring 2020;42 (6):880-885 [PubMed]
• Berends Sophie. E. Anti-TNF therapy in inflammatory bowel disease: Towards personalized medicine 2020. 251p. ISBN 9789090325651. [UvA Dissertations Online] University of Amsterdam. (Supervisors: D'Haens Geert. R. A. M., Mathot Ronald. A A.; Co-supervisor: Lowenberg Mark)
• Guo Tingjie, van Hest Reinier M., Zwep Laura B., Roggeveen Luca F., Fleuren Lucas M., Bosman Rob J., van der Voort Peter H. J., Girbes Armand R. J., Mathot Ron A. A., Elbers Paul W. G., van Hasselt Johan G. C. Correction to: Optimizing Predictive Performance of Bayesian Forecasting for Vancomycin Concentration in Intensive Care Patients (10.1007/s11095-20-02908-7) Pharmaceutical research 2020;37 (11)
• Schokker Sandor, Fusetti Fabrizia, Bonardi Francesco, Molenaar Remco J., Mathôt Ron A. A., van Laarhoven Hanneke W. M. Development and validation of an LC-MS/MS method for simultaneous quantification of co-administered trastuzumab and pertuzumab mAbs 2020;12 (1) [PubMed]
• Preijers T., Leebeek F. W. G., Cnossen M. H., Mathot R. A. A. Dosering op ma at voor individuele patient met hemofilie Pharmaceutisch Weekblad 2020;155 (18):18-21
• van Moort Iris, Preijers Tim, Hazendonk Hendrika C. A. M., Schutgens Roger E. G., Laros-van Gorkom Britta A. P., Nieuwenhuizen Laurens, van der Meer Felix J. M., Fijnvandraat Karin, Leebeek Frank W. G., Meijer Karina, Mathôt Ron A. A., Cnossen Marjon H. Dosing of factor VIII concentrate by ideal body weight is more accurate in overweight and obese haemophilia A patients British journal of clinical pharmacology 2020 [PubMed]
• Belkouz Ali, de Vos-Geelen Judith, Mathôt Ron A. A., Eskens Ferry A. L. M., van Gulik Thomas M., van Oijen Martijn G. H., Punt Cornelis J. A., Wilmink Johanna W., Klümpen Heinz-Josef Efficacy and safety of FOLFIRINOX as salvage treatment in advanced biliary tract cancer: an open-label, single arm, phase 2 trial British journal of cancer 2020;122 (5):634-639 [PubMed]
• Bijleveld Y. A., de Haan T. R., van Kaam A. H., Mathôt R. A. A. Hypothermie beïnvloedt klaring van antibiotica Pharmaceutisch Weekblad 2020;155 (9):12-13
• Kamp Jasper, Olofsen Erik, Henthorn Thomas K., van Velzen Monique, Niesters Marieke, Dahan Albert, Backman Janne T., Drover David R., Elkomy Mohammed H., Fanta Samuel, Flint Robert B., Gustafsson Lars L., Hammer Gregory B., Herd David W., Kalso Eija, Mathôt Ron A. A., Olkkola Klaus, Peltoniemi Marko, Persson Jan, Ramamoorthy Chandra, Saari Teijo I., Sherwin Catherine M. T. Ketamine Pharmacokinetics: A Systematic Review of the Literature, Meta-analysis, and Population Analysis Anesthesiology 2020:1192-1213 [PubMed]
• Berends Sophie E., Bloem Karien, de Vries Annick, Schaap Tiny, Rispens Theo, Strik Anne S., Talwar Rawina, Löwenberg Mark, DʼHaens Geert R., Mathôt Ron A. Monitoring of Adalimumab Concentrations at Home in Patients with Inflammatory Bowel Disease Using Dried Blood Samples Therapeutic drug monitoring 2020;42 (2):289-294 [PubMed]
• de Jager Nico C. B., Bukkems Laura H., Heijdra Jessica M., Hazendonk Carolien H. C. A. M., Fijnvandraat Karin, Meijer Karina, Eikenboom Jeroen, Laros - van Gorkom Britta A. P., Leebeek Frank W. G., Cnossen Marjon H., Mathôt Ron A. A., Collins P. W., Kruip M. J. H. A., Polinder S., Lock J., van Moort I., Goedhart M. C. H. J., Coppens M., Peters M., Preijers T., Brons P., van der Meer F. J. M., Schutgens R. E. G., Fischer K., Driessens M. H. E., Zwaan C. M., van Vliet I., Liesner R., Chowdary P., Keeling D. One piece of the puzzle: Population pharmacokinetics of FVIII during perioperative Haemate P®/Humate P® treatment in von Willebrand disease patients Journal of thrombosis and haemostasis 2020;18 (2):295-305 [PubMed]
• Cloesmeijer Michael E., van den Oever Huub L. A., Mathôt Ron A. A., Zeeman Marieke, Kruisdijk-Gerritsen Arriette, Bles Carmen M. A., Nassikovker Polina, de Meijer Arthur R., van Steveninck Fred L., Arbouw Maurits E. L. Optimising the dose of clonidine to achieve sedation in intensive care unit patients with population pharmacokinetics British journal of clinical pharmacology 2020;86 (8):1620-1631 [PubMed]
• Guo Tingjie, van Hest Reinier M., Zwep Laura B., Roggeveen Luca F., Fleuren Lucas M., Bosman Rob J., van der Voort Peter H. J., Girbes Armand R. J., Mathot Ron A. A., Elbers Paul W. G., van Hasselt Johan G. C. Optimizing Predictive Performance of Bayesian Forecasting for Vancomycin Concentration in Intensive Care Patients Pharmaceutical research 2020;37 (9) [PubMed]
• Preijers Tim Personalization of hemophilia treatment by pharmacokinetic-guided dosing 2020. 342p. ISBN 9789463806978. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Mathot Ron A. A., Leebeek Frank W. G.; Co-supervisor: Cnossen M. H.)
• van Moort Iris Personalizing Factor Replacement Therapy in Hemophilia 2020. 229p. [UvA Dissertations Online] Erasmus Universiteit Rotterdam: Erasmus MC. (Supervisors: Mathot Ron A. A., Leebeek Frank W. G.)
• Valke Lars L. F. G., Bukkems Laura H., Barteling Wideke, Laros-van Gorkom Britta A. P., Blijlevens Nicole M. A., Mathôt Ron A. A., van Heerde Waander L., Schols Saskia E. M. Pharmacodynamic monitoring of factor VIII replacement therapy in hemophilia A: Combining thrombin and plasmin generation Journal of thrombosis and haemostasis 2020;18 (12):3222-3231 [PubMed]
• de Vroom Suzanne L., van Hest Reinier M., van Daalen Frederike V., Kuil Sacha D., Mathôt Ron A. A., Geerlings Suzanne E., Jager Nynke G. L. Pharmacokinetic/pharmacodynamic target attainment of ciprofloxacin in adult patients on general wards with adequate and impaired renal function International journal of antimicrobial agents 2020;56 (5) [PubMed]
• Stroes Charlotte I., Schokker Sandor, Creemers Aafke, Molenaar Remco J., Hulshof Maarten C. C. M., van der Woude Stephanie O., Bennink Roel J., Mathôt Ron A. A., Krishnadath Kausilia K., Punt Cornelis J. A., Verhoeven Rob H. A., van Oijen Martijn G. H., Creemers Geert-Jan, Nieuwenhuijzen Grard A. P., van der Sangen Maurice J. C., Beerepoot Laurens V., Heisterkamp Joos, Los Maartje, Slingerland Marije, Cats Annemieke, Hospers Geke A. P., Bijlsma Maarten F., van Berge Henegouwen Mark I., Meijer Sybren L., van Laarhoven Hanneke W. M. Phase II Feasibility and Biomarker Study of Neoadjuvant Trastuzumab and Pertuzumab With Chemoradiotherapy for Resectable Human Epidermal Growth Factor Receptor 2-Positive Esophageal Adenocarcinoma: TRAP Study Journal of clinical oncology 2020;38 (5):462-471 [PubMed]
• de Jager Nico C. B., Heijdra Jessica M., Kieboom Quincy, Kruip Marieke J. H. A., Leebeek Frank W. G., Cnossen Marjon H., Mathôt Ron A. A. Population Pharmacokinetic Modeling of von Willebrand Factor Activity in von Willebrand Disease Patients after Desmopressin Administration Thrombosis and haemostasis 2020;120 (10):1407-1416 [PubMed]
• Sassen S. D. T., Mathôt R. A. A., Pieters R., de Haas V., Kaspers G. J. L., van den Bos C., Tissing W. J. E., te Loo D. M. W. W., Bierings M. B., van Westreenen M., van der Sluis I. M., Zwaan C. M. Population Pharmacokinetics and Pharmacodynamics of Ciprofloxacin Prophylaxis in Pediatric Acute Lymphoblastic Leukemia Patients Clinical infectious diseases 2020;71 (8):e281-e288 [PubMed]
• Krens Stefanie D., Hodiamont Caspar J., Juffermans Nicole P., Mathôt Ron A. A., van Hest Reinier M. Population Pharmacokinetics of Ganciclovir in Critically Ill Patients Therapeutic drug monitoring 2020;42 (2):295-301 [PubMed]
• Favié Laurent M. A., de Haan Timo R., Bijleveld Yuma A., Rademaker Carin M. A., Egberts Toine C. G., Nuytemans Debbie H. G. M., Mathôt Ron A. A., Groenendaal Floris, Huitema Alwin D. R. Prediction of Drug Exposure in Critically Ill Encephalopathic Neonates Treated With Therapeutic Hypothermia Based on a Pooled Population Pharmacokinetic Analysis of Seven Drugs and Five Metabolites Clinical pharmacology and therapeutics 2020;108 (5):1098-1106 [PubMed]
• Steins Anne, Klaassen Remy, Jacobs Igor, Schabel Matthias C., van Lier Monique G. J. T. B., Ebbing Eva A., Hectors Stefanie J., Tas Sander W., Maracle Chrissta X., Punt Cornelis J. A., Siebes Maria, Bergman Jacques J. G. H. M., Medema Jan Paul, Wilmink Johanna W., Mathot Ron A. A., Strijkers Gustav J., Bijlsma Maarten F., van Laarhoven Hanneke W. M. Rapid stromal remodeling by short-term VEGFR2 inhibition increases chemotherapy delivery in esophagogastric adenocarcinoma Molecular oncology 2020;14 (4):704-720 [PubMed]
• Labeur Tim A., Achterbergh Roos, Takkenberg Bart, van Delden Otto, Mathôt Ron, Klümpen Heinz-Josef Sorafenib for Patients with Hepatocellular Carcinoma and Child-Pugh B Liver Cirrhosis: Lessons Learned from a Terminated Study oncologist 2020;25 (9):e1274-e1279 [PubMed]
• Schütte Lisette M., van Hest Reinier M., Cnossen Marjon H., Stoof Sara C. M., Leebeek Frank W. G., Mathôt Ron A. A., Kruip Marieke J. H. A. The association between desmopressin exposure, FVIII response and side effects Haemophilia 2020 [PubMed]
• Lammers Laureen A., Achterbergh Roos, Mathôt Ron A. A., Romijn Johannes A. The effects of fasting on drug metabolism Expert opinion on drug metabolism & toxicology 2020;16 (1):79-85 [PubMed]
• Labeur Tim A., Hofsink Quincy, Takkenberg R. Bart, van Delden Otto M., Mathôt Ron A. A., Schinner Regina, Malfertheiner Peter, Amthauer Holger, Schütte Kerstin, Basu Bristi, Kuhl Christiane, Mayerle Julia, Ricke Jens, Klümpen Heinz-Josef The value of sorafenib trough levels in patients with advanced hepatocellular carcinoma–a substudy of the SORAMIC trial Acta oncologica (Stockholm, Sweden) 2020;59 (9):1028-1035 [PubMed]
• van Moort Iris, Bukkems Laura H., Heijdra Jessica M., Schutgens Roger E. G., Laros-van Gorkom Britta A. P., Nieuwenhuizen Laurens, van der Meer Felix J. M., Fijnvandraat Karin, Ypma Paula, de Maat Moniek P. M., Leebeek Frank W. G., Meijer Karina, Eikenboom Jeroen, Mathôt Ron A. A., Cnossen Marjon H. Von Willebrand Factor and Factor VIII Clearance in Perioperative Hemophilia A Patients Thrombosis and haemostasis 2020;120 (7):1056-1065 [PubMed]
• Guo Tingjie, van Hest Reinier M., Fleuren Lucas M., Roggeveen Luca F., Bosman Rob J., van der Voort Peter H. J., Girbes Armand R. J., Mathot Ron A. A., van Hasselt Johan G. C., Elbers Paul W. G. Why we should sample sparsely and aim for a higher target: Lessons from model-based therapeutic drug monitoring of vancomycin in intensive care patients British journal of clinical pharmacology 2020 [PubMed]

2019

• Berends Sophie E., Strik Anne S., Löwenberg Mark, D’Haens Geert R., Mathôt Ron A. A. Clinical Pharmacokinetic and Pharmacodynamic Considerations in the Treatment of Ulcerative Colitis Clinical pharmacokinetics 2019;58 (1):15-37 [PubMed]
• Ketharanathan Naomi, Yamamoto Yumi, Rohlwink Ursula K., Wildschut Enno D., Mathôt Ron A. A., de Lange Elizabeth C. M., de Wildt Saskia N., Argent Andrew C., Tibboel Dick, Figaji Anthony A. Combining Brain Microdialysis and Translational Pharmacokinetic Modeling to Predict Drug Concentrations in Pediatric Severe Traumatic Brain Injury: The Next Step Toward Evidence-Based Pharmacotherapy? Journal of neurotrauma 2019;36 (1):111-117 [PubMed]
• Schütte Lisette M., de Rooij Nils, Hazendonk Hendrika C. A. M., Mathôt Ron A. A., van Hest Reinier M., Leebeek Frank W. G., Cnossen Marjon H., Kruip Marieke J. H. A. Current dosing practices for perioperative factor VIII concentrate treatment in mild haemophilia A patients result in FVIII levels above target Haemophilia 2019 [PubMed]
• Schütte Lisette M., Cnossen Marjon H., van Hest Reinier M., Driessens Mariette H. E., Fijnvandraat Karin, Polinder Suzanne, Beckers Erik A. M., Coppens Michiel, Eikenboom Jeroen, Laros-van Gorkom Britta A. P., Meijer Karina, Nieuwenhuizen Laurens, Mauser-Bunschoten Evelien P., Leebeek Frank W. G., Mathôt Ron A. A., Kruip Marieke J. H. A. Desmopressin treatment combined with clotting factor VIII concentrates in patients with non-severe haemophilia A: Protocol for a multicentre single-armed trial, the DAVID study BMJ open 2019;9 (4) [PubMed]
• van Nierop F. Samuel, Meessen Emma C. E., Nelissen Kyra G. M., Achterbergh Roos, Lammers Laureen A., Vaz Frédéric M., Mathôt Ron A. A., Klümpen Heinz-Josef, Olde Damink Steven W., Schaap Frank G., Romijn Johannes A., Kemper E. Marleen, Soeters Maarten R. Differential effects of a 40-hour fast and bile acid supplementation on human GLP-1 and FGF19 responses American journal of physiology. Endocrinology and metabolism 2019;317 (3):E494-E502 [PubMed]
• Berends Sophie E., D'Haens Geert R. A. M., Schaap Tiny, de Vries Annick, Rispens Theo, Bloem Karien, Mathôt Ron A. A. Dried blood samples can support monitoring of infliximab concentrations in patients with inflammatory bowel disease: A clinical validation British journal of clinical pharmacology 2019;85 (7):1544-1551 [PubMed]
• Bijleveld Yuma A. Effect of hypothermia on the pharmacokinetics of antibiotics in neonates 2019. 236p. ISBN 9789461829511. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Mathôt Ron A. A., van Kaam Anton H. L. C., de Haan T. R.)
• Achterbergh R., Lammers L. A., Kuijsten L., Klümpen H. J., Mathôt R. A. A., Romijn J. A. Effects of nutritional status on acetaminophen measurement and exposure CLINICAL TOXICOLOGY 2019;57 (1):42-49 [PubMed]
• van den Hof Malon, Haneveld Mirthe J. Klein, Blokhuis Charlotte, Scherpbier Henriette J., Jansen Hans P. G., Kootstra Neeltje A., Dallinga-Thie Geesje M., van Deventer Sander J. H., Tsimikas Sotirios, Pajkrt Dasja, van den Hof M., Blokhuis C., Cohen S., Pajkrt D., Scherpbier H. J., Kuijpers T. W., van der Plas A., Weijsenfeld A., ter Stege J. S., Kootstra N. A., Caan M. W. A., Mutsaerts H. J. M. M., Majoie C. B. L. M., Verbraak F. D., Schmand B., Geurtsen G., Mathot R. A. A., Wit F. W. N. M., Reiss P., Teunissen C. E., Kuhle J., Meijer J. C. M. Elevated Lipoprotein(a) in Perinatally HIV-Infected Children Compared with Healthy Ethnicity-Matched Controls Open forum infectious diseases 2019;6 (9) [PubMed]
• Koedood L., de Haan T. R., Hodiamont C. J., van Haelst I. M. M., Mathot R. A. A. Evaluatie van een nieuwe Nederlandse vancomycine- doseerrichtlijn en populatiefarmacokinetiek van vancomycine bij preterme en a terme neonaten Pharmaceutisch Weekblad 2019;154 (15):19-23
• Guo Tingjie, van Hest Reinier M., Roggeveen Luca F., Fleuren Lucas M., Thoral Patrick J., Bosman Rob J., van der Voort Peter H. J., Girbes Armand R. J., Mathot Ron A. A., Elbers Paul W. G. External evaluation of population pharmacokinetic models of vancomycin in large cohorts of intensive care unit patients Antimicrobial agents and chemotherapy 2019;63 (5) [PubMed]
• Achterbergh Roos Nutritional conditioning: The effect of a short-term high fat diet on hepatic drug metabolism 2019. 145p. ISBN 9789402816044. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Romijn J. A. , Mathot R. A. A.; Co-supervisor: Klumpen H. J.)
• Strik Anne S. Personalized treatment with anti-TNF agents in inflammatory bowel disease 2019. 198p. ISBN 9789461829801. [UvA Dissertations Online] University of Amsterdam. (Supervisors: D'Haens G. R. A. M., Mathot Ronald)
• Preijers Tim, Laros-Vangorkom Britta Ap, Mathôt Ron Aa, Cnossen Marjon H. Pharmacokinetic-guided dosing of factor VIII concentrate in a morbidly obese severe haemophilia A patient undergoing orthopaedic surgery BMJ case reports 2019;12 (1) [PubMed]
• Sassen Sebastiaan D. T., Zwaan C. Michel, van der Sluis Inge M., Mathôt Ron A. A. Pharmacokinetics and population pharmacokinetics in pediatric oncology Pediatric blood & cancer 2019 [PubMed]
• Berends Sophie E., Strik Anne S., Jansen Jeroen M., de Boer Nanne K., van Egmond Pleun S., Brandse Johannan F., Mathôt Ron A., D’Haens Geert R., Löwenberg Mark Pharmacokinetics of golimumab in moderate to severe ulcerative colitis: the GO-KINETIC study Scandinavian journal of gastroenterology 2019;54 (6):700-706 [PubMed]
• Haslund-Krog Sissel Sundell, Schmidt Maria, Mathot Ron, Kryger Jensen Andreas, Jørgensen Inger Merete, Holst Helle Pharmacokinetics of prednisolone in children: An open-label, randomised, two-treatment cross-over trial investigating the bioequivalence of different prednisolone formulations in children with airway disease BMJ Paediatrics Open 2019;3 (1) [PubMed]
• Bos Jeannet C., Prins Jan M., Mistício Mabor C., Nunguiane Ginto, Lang Cláudia N., Beirão José C., Mathôt Ron A. A., van Hest Reinier M. Population pharmacokinetics with Monte Carlo simulations of gentamicin in a population of severely ill adult patients from sub-Saharan Africa Antimicrobial agents and chemotherapy 2019;63 (4) [PubMed]
• Veltkamp Floor, Khan Djera H., Reefman Christa, Veissi Susan, van Oers Hedy A., Levtchenko Elena, Mathôt Ron A. A., Florquin Sandrine, van Wijk Joanna A. E., Schreuder Michiel F., Haverman Lotte, Bouts Antonia H. M. Prevention of relapses with levamisole as adjuvant therapy in children with a first episode of idiopathic nephrotic syndrome: Study protocol for a double blind, randomised placebo-controlled trial (the LEARNS study) BMJ open 2019;9 (8):e027011 [PubMed]
• Preijers Tim, Schütte Lisette M., Kruip Marieke J. H. A., Cnossen Marjon H., Leebeek Frank W. G., van Hest Reinier M., Mathôt Ron A. A. Strategies for individualized dosing of clotting factor concentrates and desmopressin in hemophilia A and B Therapeutic drug monitoring 2019;41 (2):192-212 [PubMed]
• Sanders Fay R K, Goslings J Carel, Mathôt Ron A A, Schepers Tim Target site antibiotic concentrations in orthopedic/trauma extremity surgery:is prophylactic cefazolin adequately dosed? A systematic review and meta-analysis Acta orthopaedica 2019;90 (2):97-104 [PubMed]
• Berends Sophie E., van Steeg Tamara J., Ahsman Maurice J., Singh Sharat, Brandse Johannan F., D’Haens Geert R. A. M., Mathôt Ron A. A. Tumor necrosis factor-mediated disposition of infliximab in ulcerative colitis patients Journal of pharmacokinetics and pharmacodynamics 2019;46 (6):543–551 [PubMed]
• Berg-Lammers Laureen Ten, Achterbergh Roos, Romijn Hans, Mathot Ron Vasten kan medicijn minder effectief en veilig maken Pharmaceutisch Weekblad 2019;154 (12):12-13
• Löwenberg Mark, Vermeire Severine, Mostafavi Nahid, Hoentjen Frank, Franchimont Denis, Bossuyt Peter, Hindryckx Pieter, Rispens Theo, de Vries Annick, van der Woude C. Janneke, Berends Sophie, Ambarus Carmen A., Mathot Ron, Clasquin Esme, Baert Filip, D'Haens Geert Vedolizumab Induces Endoscopic and Histologic Remission in Patients With Crohn's Disease Gastroenterology 2019;157 (4):997-1006.e6 [PubMed]

2018

• Hazendonk H. C. A. M., Heijdra J. M., de Jager N. C. B., Veerman H. C., Boender J., van Moort I., Mathôt R. A. A., Meijer K., Laros-van Gorkom B. A. P., Eikenboom J., Fijnvandraat K., Leebeek F. W. G., Cnossen M. H. Analysis of current perioperative management with Haemate® P/Humate P® in von Willebrand disease: Identifying the need for personalized treatment Haemophilia 2018;24 (3):460-470 [PubMed]
• Kaspers Gertjan J. L., Niewerth Denise, Wilhelm Bram A. J., Scholte-van Houtem Peggy, Lopez-Yurda Marta, Berkhof Johannes, Cloos Jacqueline, de Haas Valerie, Mathôt Ron A., Attarbaschi Andishe, Baruchel André, de Bont Eveline S., Fagioli Franca, Rössig Claudia, Klingebiel Thomas, de Moerloose Barbara, Nelken Brigitte, Palumbo Giuseppe, Reinhardt Dirk, Rohrlich Pierre-Simon, Simon Pauline, von Stackelberg Arend, Zwaan Christian Michel An effective modestly intensive re-induction regimen with bortezomib in relapsed or refractory paediatric acute lymphoblastic leukaemia British journal of haematology 2018;181 (4):523-527 [PubMed]
• Molenaar Remco J., van de Venne Tim, Weterman Mariëtte J., Mathot Ron A., Klümpen Heinz-Josef, Richel Dick J., Wilmink Johanna W. A phase Ib study of everolimus combined with metformin for patients with advanced cancer Investigational new drugs 2018;36 (1):53-61 [PubMed]
• van den Hof Malon, Blokhuis Charlotte, Cohen Sophie, Scherpbier Henriette J., Wit Ferdinand W. N. M., Pistorius M. C. M., Kootstra Neeltje A., Teunissen Charlotte E., Mathot Ron A. A., Pajkrt Dasja CNS penetration of ART in HIV-infected children Journal of antimicrobial chemotherapy 2018;73 (2):484-489 [PubMed]
• Preijers T., van Moort I., Fijnvandraat K., Leebeek F. W. G., Cnossen M. H., Mathôt R. A. A. Cross-evaluation of Pharmacokinetic-Guided Dosing Tools for Factor VIII Thrombosis and haemostasis 2018;118 (3):514-525 [PubMed]
• Bijleveld Yuma A., de Haan Timo R., van der Lee Johanna H., Groenendaal Floris, Dijk Peter H., van Heijst Arno, de Jonge Rogier C. J., Dijkman Koen P., van Straaten Henrica L. M., Rijken Monique, Zonnenberg Inge A., Cools Filip, Zecic Alexandra, Nuytemans Debbie H. G. M., van Kaam Anton H., Mathôt Ron A. A. Evaluation of a System-specific Function to Describe the Pharmacokinetics of Benzylpenicillin in Term Neonates Undergoing Moderate Hypothermia Antimicrobial agents and chemotherapy 2018;62 (4):e02311-17 [PubMed]
• Berends Sophie E., Strik Anne S., van Selm Juliet C., Löwenberg Mark, Ponsioen Cyriel Y., D'Haens Geert R., Mathôt Ron A. Explaining Interpatient Variability in Adalimumab Pharmacokinetics in Patients with Crohn's Disease Therapeutic drug monitoring 2018;40 (2):202-211 [PubMed]
• Boelens A. D., Mathôt R. A. A., Vlaar A. P. J., Bouman C. S. C. Glucarpidase treatment for methotrexate intoxication: a case report and review of the literature Netherlands journal of medicine 2018;76 (1):36-39 [PubMed]
• ten Berg-Lammers Laureen A. Nutritional conditioning: The effect of fasting on drug metabolism 2018. ISBN 9789402807950. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Mathôt R. A. A., Romijn J. A.)
• Lammers Laureen A., Achterbergh Roos, Romijn Johannes A., Mathôt Ron A. A. Nutritional Status Differentially Alters Cytochrome P450 3A4 (CYP3A4) and Uridine 5′-Diphospho-Glucuronosyltransferase (UGT) Mediated Drug Metabolism: Effect of Short-Term Fasting and High Fat Diet on Midazolam Metabolism European journal of drug metabolism and pharmacokinetics 2018;43 (6):751-767 [PubMed]
• Hazendonk H. C. A. M., Preijers T., Liesner R., Chowdary P., Hart D., Keeling D., Driessens M. H. E., Laros-van Gorkom B. A. P., van der Meer F. J. M., Meijer K., Fijnvandraat K., Leebeek F. W. G., Mathôt R. A. A., Collins P. W., Cnossen M. H. Perioperative replacement therapy in haemophilia B: An appeal to “B” more precise Haemophilia 2018;24 (4):611-618 [PubMed]
• Schütte L. M., van Hest R. M., Stoof S. C. M., Leebeek F. W. G., Cnossen M. H., Kruip M. J. H. A., Mathôt R. A. A. Pharmacokinetic Modelling to Predict FVIII:C Response to Desmopressin and Its Reproducibility in Nonsevere Haemophilia A Patients Thrombosis and haemostasis 2018;118 (04):621-629 [PubMed]
• Bos Jeannet C., van Hest Reinier M., Mistício Mabor C., Nunguiane Ginto, Lang Cláudia N., Beirão José C., Mathôt Ron A. A., Prins Jan M. Pharmacokinetics and Pharmacodynamic Target Attainment of Benzylpenicillin in an Adult Severely ill Sub-Saharan African Patient Population Clinical infectious diseases 2018;66 (8):1261–1269 [PubMed]
• Bos Jeannet C., Prins Jan M., Mistício Mabor C., Nunguiane Ginto, Lang Cláudia N., Beirão José C., Mathôt Ron A. A., van Hest Reinier M. Pharmacokinetics and pharmacodynamic target attainment of ceftriaxone in adult severely ill sub-Saharan African patients: A population pharmacokinetic modelling study Journal of antimicrobial chemotherapy 2018;73 (6):1620-1629 [PubMed]
• Franken Linda G., de Winter Brenda C. M., Masman Anniek D., van Dijk Monique, Baar Frans P. M., Tibboel Dick, Koch Birgit C. P., van Gelder Teun, Mathot Ron A. A. Population pharmacodynamic modelling of midazolam induced sedation in terminally ill adult patients British journal of clinical pharmacology 2018;84 (2):320-330 [PubMed]
• Preijers T., Hazendonk H. C. A. M., Liesner R., Chowdary P., Driessens M. H. E., Hart D., Keeling D., Laros-van Gorkom B. A. P., van der Meer F. J. M., Meijer K., Fijnvandraat K., Leebeek F. W. G., Collins P. W., Cnossen M. H., Mathôt R. A. A., Kruip M. J. A. H., Polinder S., Lock J., van Moort I., Heijdra J. M., Nederlof A., de Jager N., Coppens M., Peters M., Tamminga R. Y. J., Brons P., Eikenboom H. C. J., Schutgens R. E. G., Fischer K., Zwaan C. M., van Vliet I. Population pharmacokinetics of factor IX in hemophilia B patients undergoing surgery Journal of thrombosis and haemostasis 2018;16 (11):2196-2207 [PubMed]
• Nederlof Angelique, Mathôt Ron A. A., Leebeek Frank W. G., Fijnvandraat Karin, Fischer Kathelijn, Cnossen Marjon H. Positioning extended half-life concentrates for future use: a practical proposal Haemophilia 2018;24 (5):e369-e372 [PubMed]
• Hazendonk H. C. A. M., van Moort I., Mathôt R. A. A., Fijnvandraat K., Leebeek F. W. G., Collins P. W., Cnossen M. H. Setting the stage for individualized therapy in hemophilia: What role can pharmacokinetics play? Blood reviews 2018;32 (4):265-271 [PubMed]
• Lammers Laureen A., Achterbergh Roos, Romijn Johannes A., Mathôt Ron A. A. Short-Term Fasting Alters Pharmacokinetics of Cytochrome P450 Probe Drugs: Does Protein Binding Play a Role? European journal of drug metabolism and pharmacokinetics 2018;43 (2):251-257 [PubMed]

2017

• Hodiamont Caspar J., Juffermans Nicole P., Bouman Catherine S. C., de Jong Menno D., Mathôt Ron A. A., van Hest Reinier M. Determinants of gentamicin concentrations in critically ill patients: a population pharmacokinetic analysis International journal of antimicrobial agents 2017;49 (2):204-211 [PubMed]
• Lammers Laureen A., Achterbergh Roos, van Schaik Ron H. N., Romijn Johannes A., Mathôt Ron A. A. Effect of Short-Term Fasting on Systemic Cytochrome P450-Mediated Drug Metabolism in Healthy Subjects: A Randomized, Controlled, Crossover Study Using a Cocktail Approach Clinical pharmacokinetics 2017;56 (10):1231-1244 [PubMed]
• van Egmond P. S. , van Eijkelenburg Natasha K. A., Zwaan C. M., Mathot Ronald A. A. Evaluatie van doseerrichtlijnen en populatiefarmaco-kinetiek van vancomycine bij kinderen met kanker Pharmaceutisch Weekblad 2017;152 (46):21-24
• Strik Anne S., Berends Sophie E., Mathôt Ron A., D'Haens Geert R., Löwenberg Mark Golimumab for moderate to severe ulcerative colitis Expert review of gastroenterology & hepatology 2017;11 (5):401-406 [PubMed]
• Franken Linda G., Masman Anniek D., de Winter Brenda C. M., Baar Frans P. M., Tibboel Dick, van Gelder Teun, Koch Birgit C. P., Mathot Ron A. A. Hypoalbuminaemia and decreased midazolam clearance in terminally ill adult patients, an inflammatory effect? British journal of clinical pharmacology 2017;83 (8):1701-1712 [PubMed]
• Preijers T., Hazendonk H. C. A. M., Fijnvandraat K., Leebeek F. W. G., Cnossen M. H., Mathôt R. A. A. In silico evaluation of limited blood sampling strategies for individualized recombinant factor IX prophylaxis in hemophilia B patients Journal of thrombosis and haemostasis 2017;15 (9):1737-1746 [PubMed]
• Bos Jeannet C., Mistício Mabor C., Nunguiane Ginto, Mathôt Ron A. A., van Hest Reinier M., Prins Jan M. Paracetamol clinical dosing routine leads to paracetamol underexposure in an adult severely ill sub-Saharan African hospital population: a drug concentration measurement study BMC research notes 2017;10 (1):671 [PubMed]
• Hazendonk H. C. A. M. Pharmacokinetic-guided dosing of clotting factor concentrates in bleeding disorders : towards individualization of treatment 2017. ISBN 9789492683373. [UvA Dissertations Online] Erasmus University Rotterdam: ErasmusMC. (Supervisors: Leebeek F. W. G., Mathôt R. A. A., Cnossen M. H.)
• Cheung Y. Whitney, Barco Stefano, Mathôt Ron A. A., van den Dool Erik-Jan, Stroobants An K., Serlie Mireille J., Middeldorp Saskia, Coppens Michiel Pharmacokinetics of dabigatran etexilate and rivaroxaban in patients with short bowel syndrome requiring parenteral nutrition: The PDER PAN study Thrombosis research 2017;160:76-82 [PubMed]
• Flint Robert B., Brouwer Carole N. M., Kränzlin Anne S. C., Lie-A-Huen Loraine, Bos Albert P., Mathôt Ron A. A. Pharmacokinetics of S-ketamine during prolonged sedation at the pediatric intensive care unit Paediatric anaesthesia 2017;27 (11):1098-1107 [PubMed]
• Bijleveld Yuma A., van den Heuvel Maria E., Hodiamont Caspar J., Mathôt Ron A. A., de Haan Timo R. Population Pharmacokinetics and Dosing Considerations for Gentamicin in Newborns with Suspected or Proven Sepsis Caused by Gram-Negative Bacteria Antimicrobial agents and chemotherapy 2017;61 (1):e01304-16 [PubMed]
• Franken L. G., Mathot R. A. A., Masman A. D., Baar F. P. M., Tibboel D., van Gelder T., Koch B. C. P., de Winter B. C. M. Population pharmacokinetics of haloperidol in terminally ill adult patients European journal of clinical pharmacology 2017;73 (10):1271-1277 [PubMed]
• Kleiber Niina, Mathôt Ron A. A., Ahsman Maurice J., Wildschut Enno D., Tibboel Dick, de Wildt Saskia N. Population pharmacokinetics of intravenous clonidine for sedation during paediatric extracorporeal membrane oxygenation and continuous venovenous hemofiltration British journal of clinical pharmacology 2017;83 (6):1227-1239 [PubMed]
• Sassen Sebastiaan D. T., Mathôt Ron A. A., Pieters Rob, Kloos Robin Q. H., de Haas Valérie, Kaspers Gertjan J. L., van den Bos Cor, Tissing Wim J. E., te Loo Maroeska, Bierings Marc B., Kollen Wouter J. W., Zwaan Christian M., van der Sluis Inge M. Population pharmacokinetics of intravenous Erwinia asparaginase in pediatric acute lymphoblastic leukemia patients Haematologica 2017;102 (3):552-561 [PubMed]
• Lammers Laureen A., Achterbergh Roos, Pistorius Marcel C. M., Romijn Johannes A., Mathôt Ron A. A. Quantitative Method for Simultaneous Analysis of Acetaminophen and 6 Metabolites Therapeutic drug monitoring 2017;39 (2):172-179 [PubMed]
• Molenaar Remco J., Coelen Robert J. S., Khurshed Mohammed, Roos Eva, Caan Matthan W. A., van Linde Myra E., Kouwenhoven Mathilde, Bramer Jos A. M., Bovée Judith V. M. G., Mathôt Ron A., Klümpen Heinz-Josef, van Laarhoven Hanneke W. M., van Noorden Cornelis J. F., Vandertop W. Peter, Gelderblom Hans, van Gulik Thomas M., Wilmink Johanna W. Study protocol of a phase IB/II clinical trial of metformin and chloroquine in patients with IDH1-mutated or IDH2-mutated solid tumours BMJ open 2017;7 (6):e014961 [PubMed]
• Strik A. S., van den Brink G. R., Ponsioen C., Mathot R., Löwenberg M., D'Haens G. R. Suppression of anti-drug antibodies to infliximab or adalimumab with the addition of an immunomodulator in patients with inflammatory bowel disease Alimentary pharmacology & therapeutics 2017;45 (8):1128-1134 [PubMed]
• Steins Anne, Ebbing Eva A., Pistorius Marcel C. M., Waasdorp Cynthia, Krishnadath Kausilia K., Medema Jan Paul, Wilmink Johanna W., Mathôt Ron A. A., Bijlsma Maarten F., van Laarhoven Hanneke W. M. Systemic effects of angiogenesis inhibition alter pharmacokinetics and intratumoral delivery of nab-paclitaxel Drug delivery 2017;24 (1):1801-1810 [PubMed]
• Hodiamont C. J., Janssen J. M., de Jong M. D., Mathôt R. A., Juffermans N. P., van Hest R. M. Therapeutic Drug Monitoring of Gentamicin Peak Concentrations in Critically Ill Patients Therapeutic drug monitoring 2017;39 (5):522-530 [PubMed]

2016

• Bijleveld Yuma A., de Haan Timo R., van der Lee Hanneke J. H., Groenendaal Floris, Dijk Peter H., van Heijst Arno, de Jonge Rogier C. J., Dijkman Koen P., van Straaten Henrica L. M., Rijken Monique, Zonnenberg Inge A., Cools Filip, Zecic Alexandra, Nuytemans Debbie H. G. M., van Kaam Anton H., Mathot Ron A. A. Altered gentamicin pharmacokinetics in term neonates undergoing controlled hypothermia British journal of clinical pharmacology 2016;81 (6):1067-1077 [PubMed]
• Hazendonk Hendrika, Fijnvandraat Karin, Lock Janske, Driessens Mariëtte, van der Meer Felix, Meijer Karina, Kruip Marieke, Gorkom Britta Laros-van, Peters Marjolein, de Wildt Saskia, Leebeek Frank, Cnossen Marjon, Mathôt Ron A population pharmacokinetic model for perioperative dosing of factor VIII in hemophilia A patients Haematologica 2016;101 (10):1159-1169 [PubMed]
• Achterbergh Roos, Lammers Laureen A., van Nierop Samuel, Klümpen Heinz-Josef, Soeters Maarten R., Mathôt Ron A. A., Romijn Johannes A. A short-term high fat diet increases exposure to midazolam and omeprazole in healthy subjects Expert opinion on drug metabolism & toxicology 2016;12 (7):715-720 [PubMed]
• Masman Anniek D. Considerations of pharmacotherapy in hospice end-of-life care 2016. 207p. ISBN 9789461698780. [UvA Dissertations Online] Erasmus Universiteit Rotterdam: Faculteit Geneeskunde. (Supervisors: Tibboel D., Mathôt R. A. A.; Co-supervisor: van Dijk M.)
• Masman Anniek D. Considerations of Pharmacotherapy in Hospice End-of-Life Care: Overwegingen over farmacotherapie in hospice einde-van-het-leven zorg 2016. 207p. ISBN 9789461698780. [UvA Dissertations Online] Erasmus University Rotterdam. (Supervisors: Tibboel D., Mathot R. A. A.; Co-supervisor: van Dijk M.)
• Lock J., de Bekker-Grob E. W., Urhan G., Peters M., Meijer K., Brons P., van der Meer F. J. M., Driessens M. H. E., Collins P. W., Fijnvandraat K., Leebeek F. W. G., Cnossen M. H., Mathôt R. A. A., Kruip M. H., de Wildt S. N., Polinder S., Ista W. G., Hazendonk H. C. A. M., van Moort I., Steyerberg E. W., Borsboom G. J. J. M., Preijers T., Stokhuijzen E., Coppens M., Middeldorp S., Tamminga R. Y. J., Laros-van Gorkom B. A. P., Eikenboom H. C. J., Schutgens R. E. G., de Meris J., Zwaan C. M., Ramnarain S., Bosschaart-Castermans R. M. M., Rotte A. E., Koolma A., Ammerlaan A. C. J. Facilitating the implementation of pharmacokinetic-guided dosing of prophylaxis in haemophilia care by discrete choice experiment Haemophilia 2016;22 (1):e1-e10 [PubMed]
• de Vries E. M., Lammers L. A., Achterbergh R., Klümpen H.-J., Mathot R. A. A., Boelen A., Romijn J. A. Fasting-Induced Changes in Hepatic P450 Mediated Drug Metabolism Are Largely Independent of the Constitutive Androstane Receptor CAR PLoS ONE 2016;11 (7):e0159552 [PubMed]
• Hazendonk H. C. A. M., Lock J., Mathôt R. A. A., Meijer K., Peters M., Laros-van Gorkom B. A. P., van der Meer F. J. M., Driessens M. H. E., Leebeek F. W. G., Fijnvandraat K., Cnossen M. H. Perioperative treatment of hemophilia A patients: blood group O patients are at risk of bleeding complications Journal of thrombosis and haemostasis 2016;14 (3):468-478 [PubMed]
• Valkenburg Abraham J., Calvier Elisa A. M., van Dijk Monique, Krekels Elke H. J., O'Hare Brendan P., Casey William F., Mathôt Ron A. A., Knibbe Catherijne A. J., Tibboel Dick, Breatnach Cormac V. Pharmacodynamics and Pharmacokinetics of Morphine After Cardiac Surgery in Children With and Without Down Syndrome Pediatric critical care medicine 2016;17 (10):930-938 [PubMed]
• Franken L. G., de Winter B. C. M., van Esch H. J., van Zuylen L., Baar F. P. M., Tibboel D., Mathôt R. A. A., van Gelder T., Koch B. C. P. Pharmacokinetic considerations and recommendations in palliative care, with focus on morphine, midazolam and haloperidol Expert opinion on drug metabolism & toxicology 2016;12 (6):669-680 [PubMed]
• Brandse Johannan F., Mathôt Ron A., van der Kleij Desiree, Rispens Theo, Ashruf Yaël, Jansen Jeroen M., Rietdijk Svend, Löwenberg Mark, Ponsioen Cyriel Y., Singh Sharat, van den Brink Gijs R., D'Haens Geert R. Pharmacokinetic Features and Presence of Antidrug Antibodies Associate With Response to Infliximab Induction Therapy in Patients With Moderate to Severe Ulcerative Colitis Clinical gastroenterology and hepatology 2016;14 (2):251-8.e1-2 [PubMed]
• Hazendonk Hendrika C. A. M., Kruip Marieke J. H. A., Mathôt Ron A. A., Cnossen Marjon H. Pharmacokinetic-guided dosing of factor VIII concentrate in a patient with haemophilia during renal transplantation BMJ case reports 2016;2016:217069 [PubMed]
• Franken Linda G., Masman Anniek D., de Winter Brenda C. M., Koch Birgit C. P., Baar Frans P. M., Tibboel Dick, van Gelder Teun, Mathot Ron A. A. Pharmacokinetics of Morphine, Morphine-3-Glucuronide and Morphine-6-Glucuronide in Terminally Ill Adult Patients Clinical pharmacokinetics 2016;55 (6):697-709 [PubMed]
• Masman Anniek D., Tibboel Dick, Baar Frans P. M., van Dijk Monique, Mathot Ron A. A., van Gelder Teun Prevalence and Implications of Abnormal Laboratory Results in Patients in the Terminal Phase of Life Journal of palliative medicine 2016;19 (8):822-829 [PubMed]
• Lammers Laureen A., Achterbergh Roos, Pistorius Marcel C. M., Bijleveld Yuma, de Vries Emmely M., Boelen Anita, Klümpen Heinz-Josef, Romijn Johannes A., Mathôt Ron A. A. Quantitative Method for Simultaneous Analysis of a 5-Probe Cocktail for Cytochrome P450 Enzymes Therapeutic drug monitoring 2016;38 (6):761-768 [PubMed]
• Prytuła Agnieszka A., Cransberg Karlien, Bouts Antonia H. M., van Schaik Ron H. N., de Jong Huib, de Wildt Saskia N., Mathôt Ron A. A. The Effect of Weight and CYP3A5 Genotype on the Population Pharmacokinetics of Tacrolimus in Stable Paediatric Renal Transplant Recipients Clinical pharmacokinetics 2016;55 (9):1129-1143 [PubMed]

2015

• Brandse Johannan F., van den Brink Gijs R., Wildenberg Manon E., van der Kleij Desiree, Rispens Theo, Jansen Jeroen M., Mathôt Ron A., Ponsioen Cyriel Y., Löwenberg Mark, D'Haens Geert R. A. M. Loss of Infliximab Into Feces Is Associated With Lack of Response to Therapy in Patients With Severe Ulcerative Colitis Gastroenterology 2015;149 (2):350-5.e2 [PubMed]
• Masman Anniek D., van Dijk Monique, Tibboel Dick, Baar Frans P. M., Mathôt Ron A. A. Medication use during end-of-life care in a palliative care centre International journal of clinical pharmacy 2015;37 (5):767-775 [PubMed]
• Kordes Sil, Pollak Michael N., Zwinderman Aeilko H., Mathôt Ron A., Weterman Mariëtte J., Beeker Aart, Punt Cornelis J., Richel Dick J., Wilmink Johanna W. Metformin in patients with advanced pancreatic cancer: a double-blind, randomised, placebo-controlled phase 2 trial lancet oncology 2015;16 (7):839-847 [PubMed]
• Lammers Laureen A., Achterbergh Roos, de Vries Emmely M., van Nierop F. Samuel, Klümpen Heinz-Josef, Soeters Maarten R., Boelen Anita, Romijn Johannes A., Mathôt Ron A. A. Short-term fasting alters cytochrome P450-mediated drug metabolism in humans Drug metabolism and disposition: the biological fate of chemicals 2015;43 (6):819-828 [PubMed]
• Hazendonk Hendrika C. A. M., van Moort Iris, Fijnvandraat Karin, Kruip Marieke J. H. A., Laros-van Gorkom Britta A. P., van der Meer Felix J. M., Meijer Karina, Peters Marjolein, Schutgens Roger E. G., Zwaan Christian M., Driessens Mariette H. E., Polinder Suzanne, Leebeek Frank W. G., Mathôt Ron A. A., Cnossen Marjon H. The "OPTI-CLOT" trial. A randomised controlled trial on periOperative PharmacokineTIc-guided dosing of CLOTting factor concentrate in haemophilia A Thrombosis and haemostasis 2015;114 (3):639-644 [PubMed]

2014

• Hanff Lidwien M., Mathot Ron A. A., Smeets Oscar, Postma Doerine J., Ramnarain Satianand, Vermes Andras, Pieters Rob, Zwaan C. Michel A novel 6-mercaptopurine oral liquid formulation for pediatric acute lymphoblastic leukemia patients - results of a randomized clinical trial International journal of clinical pharmacology and therapeutics 2014;52 (8):653-662 [PubMed]
• Bijleveld Yuma, de Haan Timo, Toersche Jan, Jorjani Sona, van der Lee Johanna, Groenendaal Floris, Dijk Peter, van Heijst Arno, Gavilanes Antonio W. D., de Jonge Rogier, Dijkman Koen P., van Straaten Henrica, Rijken Monique, Zonnenberg Inge, Cools Filip, Nuytemans Debbie, Mathôt Ron A simple quantitative method analysing amikacin, gentamicin, and vancomycin levels in human newborn plasma using ion-pair liquid chromatography/tandem mass spectrometry and its applicability to a clinical study Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2014;951-952:110-118 [PubMed]
• Sanders Stefan J. W. J., Bijleveld Yuma A., Sinkeler Fleur, Kemper Elles M., Pajkrt Dasja, van de Wetering Marianne, van Eijkelenburg Natasha K. A., Mathôt Ron A. A. Clinical evaluation of vancomycin dosage in pediatric oncology patients Pediatric infectious disease journal 2014;33 (7):731-733 [PubMed]
• Sinkeler Fleur S., de Haan Timo R., Hodiamont Caspar J., Bijleveld Yuma A., Pajkrt Dasja, Mathôt Ron A. A. Inadequate vancomycin therapy in term and preterm neonates: a retrospective analysis of trough serum concentrations in relation to minimal inhibitory concentrations BMC pediatrics 2014;14:193 [PubMed]
• Wang Chenguang, Allegaert Karel, Tibboel Dick, Danhof Meindert, van der Marel Caroline D., Mathot Ron A. A., Knibbe Catherijne A. J. Population pharmacokinetics of paracetamol across the human age-range from (pre)term neonates, infants, children to adults Journal of clinical pharmacology 2014;54 (6):619-629 [PubMed]
• Bikker Pieternella Cornelia Variability in response to antihypertensive drug therapy: From population based therapy towards individualized treatment 2014. 211p. ISBN 9789462594029. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Koopmans R. P., Mathôt R. A. A.; Co-supervisor: van Hest R. M.)

2013

• Seçilir A., Schrier L., Bijleveld Y. A., Toersche J. H., Jorjani S., Burggraaf J., van Gerven J., Mathôt R. A. A. Determination of methylphenidate in plasma and saliva by liquid chromatography/tandem mass spectrometry Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2013;923-924:22-28 [PubMed]
• Wildschut Enno D., de Wildt Saskia N., Mâthot Ron A. A., Reiss I. K. M., Tibboel Dick, van den Anker John Effect of hypothermia and extracorporeal life support on drug disposition in neonates Seminars in fetal & neonatal medicine 2013;18 (1):23-27 [PubMed]
• Ceelie Ilse, de Wildt Saskia N., van Dijk Monique, van den Berg Margreeth M. J., van den Bosch Gerbrich E., Duivenvoorden Hugo J., de Leeuw Tom G., Mathôt Ron, Knibbe Catherijne A. J., Tibboel Dick Effect of intravenous paracetamol on postoperative morphine requirements in neonates and infants undergoing major noncardiac surgery: a randomized controlled trial JAMA 2013;309 (2):149-154 [PubMed]
• van Rijn-Bikker Petra C., Snelder Nelleke, Ackaert Oliver, van Hest Reinier M., Ploeger Bart A., van Montfrans Gert A., Koopmans Richard P., Mathôt Ron A. Nonlinear mixed effects modeling of the diurnal blood pressure profile in a multiracial population American journal of hypertension 2013;26 (9):1103-1113 [PubMed]
• van Rijn-Bikker Petra C., Ackaert Oliver, Snelder Nelleke, van Hest Reinier M., Ploeger Bart A., Koopmans Richard P., Mathôt Ron A. A. Pharmacokinetic-pharmacodynamic modeling of the antihypertensive effect of eprosartan in Black and White hypertensive patients Clinical pharmacokinetics 2013;52 (9):793-803 [PubMed]

2012

• Hunfeld N. G., Touw D. J., Mathot R. A., van Schaik R. H., Kuipers E. J. A comparison of the acid-inhibitory effects of esomeprazole and rabeprazole in relation to pharmacokinetics and CYP2C19 polymorphism Alimentary pharmacology & therapeutics 2012;35 (7):810-818 [PubMed]
• Sanders S. J. W. J., Bijleveld Y. A., Kemper E. M., Lie-A-Huen L., Mathot R. A. A. Evaluatie van de doseerrichtlijn voor vancomycine bij kinderen met kanker Pharmaceutisch Weekblad 2012;147 (24):99-102
• Prytula Agnieszka A., Bouts Antonia H., Mathot Ron A. A., van Gelder Teun, Croes Ludwig K., Hop Wim, Cransberg Karlien Intra-patient variability in tacrolimus trough concentrations and renal function decline in pediatric renal transplant recipients Pediatric transplantation 2012;16 (6):613-618 [PubMed]
• de Haan Timo R., Bijleveld Yuma A., van der Lee Johanna H., Groenendaal Floris, van den Broek Marcel P. H., Rademaker Carin M. A., van Straaten Henrica L. M., van Weissenbruch Mirjam M., Vermeulen Jeroen R., Dijk Peter H., Dudink Jeroen, Rijken Monique, van Heijst Arno, Dijkman Koen P., Gavilanes Danilo, van Kaam Anton H., Offringa Martin, Mathôt Ron A. A. Pharmacokinetics and pharmacodynamics of medication in asphyxiated newborns during controlled hypothermia. The PharmaCool multicenter study BMC pediatrics 2012;12 (1):45 [PubMed]
• Wildschut E. D., Ahsman M. J., Houmes R. J., Pokorna P., de Wildt S. N., Mathot R. A. A., Tibboel D. Pharmacotherapy in Neonatal and Pediatric Extracorporeal Membrane Oxygenation (ECMO) Current drug metabolism 2012;13 (6):767-777 [PubMed]
• Hunfeld N. G. M., Touw D. J., Mathot R. A. A., Mulder P. G. H., van Schaik R. H. N., Kuipers E. J., Kooiman J. C., Geus W. P. Vergelijking van de zuurremmende effecten van esomeprazol en pantoprazol in relatie tot farmacokinetiek en CYP2C19-polymorfisme Pharmaceutisch Weekblad 2012;147 (50):198-202

2011

• Ceelie Ilse, James Laura P., Gijsen Violette, Mathot Ron A. A., Ito Shinya, Tesselaar Coranne D., Tibboel Dick, Koren Gideon, de Wildt Saskia N. Acute liver failure after recommended doses of acetaminophen in patients with myopathies Critical care medicine 2011;39 (4):678-682 [PubMed]
• de Winter Brenda C. M., Mathot Ron A. A., Sombogaard Ferdi, Vulto Arnold G., van Gelder Teun Nonlinear relationship between mycophenolate mofetil dose and mycophenolic acid exposure: implications for therapeutic drug monitoring Clinical journal of the American Society of Nephrology 2011;6 (3):656-663 [PubMed]
• Ahsman Maurice J., Tibboel Dick, Mathot Ron A. A., de Wildt Saskia N. Sample collection, biobanking, and analysis Handbook of experimental pharmacology 2011;205:203-217 [PubMed]
• Engels Frederike K., Loos Walter J., van der Bol Jessica M., de Bruijn Peter, Mathijssen Ron H. J., Verweij Jaap, Mathot Ron A. A. Therapeutic drug monitoring for the individualization of docetaxel dosing: a randomized pharmacokinetic study Clinical cancer research 2011;17 (2):353-362 [PubMed]
• Meesters Roland J. W., den Boer Ethan, Mathot Ron A. A., de Jonge Robert, van Klaveren Rob J., Lindemans Jan, Luider Theo M. Ultrafast selective quantification of methotrexate in human plasma by high-throughput MALDI-isotope dilution mass spectrometry Bioanalysis 2011;3 (12):1369-1378 [PubMed]

2010

• Hunfeld N. G., Touw D. J., Mathot R. A., Mulder P. G. H., van Schaik R. H., Kuipers E. J., Kooiman J. C., Geus W. P. A comparison of the acid-inhibitory effects of esomeprazole and pantoprazole in relation to pharmacokinetics and CYP2C19 polymorphism Alimentary pharmacology & therapeutics 2010;31 (1):150-159 [PubMed]
• Wildschut E. D., Ahsman M. J., Allegaert K., Mathot R. A. A., Tibboel D. Determinants of drug absorption in different ECMO circuits Intensive care medicine 2010;36 (12):2109-2116 [PubMed]
• Ahsman Maurice J. Determinants of pharmacokinetic variability during extracorporeal membrane oxygenation. A roadmap to rational pharmacotherapy in children 2010. 222p. ISBN 9789085590316. [UvA Dissertations Online] Erasmus University Rotterdam. (Supervisor: Tibboel D.; Co-supervisor: Mathôt R. A. A.)
• de Winter Brenda C. M., Mathot Ron A. A., Sombogaard Ferdi, Neumann Irmgard, van Hest Reinier M., Doorduijn Jeanette K., van Gelder Teun Differences in clearance of mycophenolic acid among renal transplant recipients, hematopoietic stem cell transplant recipients, and patients with autoimmune disease Therapeutic drug monitoring 2010;32 (5):606-614 [PubMed]
• Wildschut Enno D. Drug therapies in neonates and children during extracorporeal membrane oxygenation (ECMO) 2010. 210p. ISBN 9789085590286. [UvA Dissertations Online] Erasmus University Rotterdam. (Supervisor: Tibboel D.; Co-supervisors: Mathôt R. A. A., de Wildt S. N.)
• de Geus Hilde, Mathôt Ron, van der Hoven Ben, Tjoa Mila, Bakker Jan Enhanced paracetamol clearance with molecular adsorbents recirculating system (MARS®) in severe autointoxication Blood purification 2010;30 (2):118-119 [PubMed]
• Wildschut E. D., Hanekamp M. N., Vet N. J., Houmes R. J., Ahsman M. J., Mathot R. A. A., de Wildt S. N., Tibboel D. Feasibility of sedation and analgesia interruption following cannulation in neonates on extracorporeal membrane oxygenation Intensive care medicine 2010;36 (9):1587-1591 [PubMed]
• Borra Lennaert C. P., Roodnat Joke I., Kal Judith A., Mathot Ron A. A., Weimar Willem, van Gelder Teun High within-patient variability in the clearance of tacrolimus is a risk factor for poor long-term outcome after kidney transplantation Nephrology, dialysis, transplantation 2010;25 (8):2757-2763 [PubMed]
• Sombogaard Ferdi Inosine monophosphate dehydrogenase (IMPDH) activity as a marker for immunosuppressiva action of mycophenolic acid (MPA) 2010. 224p. ISBN 9789788559931. [UvA Dissertations Online] Erasmus University Rotterdam. (Supervisor: Vulto A. G.; Co-supervisors: Mathôt R. A. A., van Gelder T.)
• Buitenkamp Trudy D., Mathôt Ron A. A., de Haas Valerie, Pieters Rob, Zwaan C. Michel Methotrexate-induced side effects are not due to differences in pharmacokinetics in children with Down syndrome and acute lymphoblastic leukemia Haematologica 2010;95 (7):1106-1113 [PubMed]
• Ahsman Maurice J., Wildschut Enno D., Tibboel Dick, Mathot Ron A. Pharmacokinetics of cefotaxime and desacetylcefotaxime in infants during extracorporeal membrane oxygenation Antimicrobial agents and chemotherapy 2010;54 (5):1734-1741 [PubMed]
• Ahsman Maurice J., Hanekamp Manon, Wildschut Enno D., Tibboel Dick, Mathot Ron A. A. Population pharmacokinetics of midazolam and its metabolites during venoarterial extracorporeal membrane oxygenation in neonates Clinical pharmacokinetics 2010;49 (6):407-419 [PubMed]
• de Winter Brenda C. M. Population pharmacokinetics of mycophenolate mofetil and enteric coated mycophenolate sodium 2010. 228p. ISBN 9789085599388. [UvA Dissertations Online] Erasmus University Rotterdam. (Supervisor: Vulto A. G.; Co-supervisors: Mathôt R. A. A., van Gelder T.)
• Blonk Maren I., van der Nagel Bart C., Smit Liesbeth S., Mathot Ron A. A. Quantification of levetiracetam in plasma of neonates by ultra performance liquid chromatography-tandem mass spectrometry Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878 (7-8):675-681 [PubMed]
• Ahsman Maurice J., van der Nagel Bart C., Mathot Ron A. Quantification of midazolam, morphine and metabolites in plasma using 96-well solid-phase extraction and ultra-performance liquid chromatography-tandem mass spectrometry Biomedical chromatography 2010;24 (9):969-976 [PubMed]
• Ahsman Maurice J., Witjes Bregje C., Wildschut Enno D., Sluiter Ilona, Vulto Arnold G., Tibboel Dick, Mathot Ron A. Sildenafil exposure in neonates with pulmonary hypertension after administration via a nasogastric tube Archives of disease in childhood. Fetal and neonatal edition 2010;95 (2):F109-F114 [PubMed]
• Witjes Bregje C., Ahsman Maurice J., van der Nagel Bart C., Tibboel Dick, Mathot Ron A. Simultaneous assay of sildenafil and desmethylsildenafil in neonatal plasma by ultra-performance liquid chromatography-tandem mass spectrometry Biomedical chromatography 2010;24 (2):180-185 [PubMed]
• Schenk P. W., van Vliet M., Mathot R. A. A., van Gelder T., Vulto A. G., van Fessem M. A. C., Verploegh-van Rij S., Lindemans J., Bruijn J. A., van Schaik R. H. N. The CYP2C19*17 genotype is associated with lower imipramine plasma concentrations in a large group of depressed patients pharmacogenomics journal 2010;10 (3):219-225 [PubMed]

2009

• van de Sande Wendy W. J., Mathot Ron A. A., ten Kate Marian T., van Vianen Wim, Tavakol Mehri, Rijnders Bart J. A., Bakker-Woudenberg Irma A. J. M. Combination therapy of advanced invasive pulmonary aspergillosis in transiently neutropenic rats using human pharmacokinetic equivalent doses of voriconazole and anidulafungin Antimicrobial agents and chemotherapy 2009;53 (5):2005-2013 [PubMed]
• Glander Petra, Sombogaard Ferdi, Budde Klemens, van Gelder Teun, Hambach Pia, Liefeldt Lutz, Lorkowski Christine, Mai Marco, Neumayer Hans H., Vulto Arnold G., Mathot Ron A. Improved assay for the nonradioactive determination of inosine 5'-monophosphate dehydrogenase activity in peripheral blood mononuclear cells Therapeutic drug monitoring 2009;31 (3):351-359 [PubMed]
• Sombogaard Ferdi, Peeters Annemiek M. A., Baan Carla C., Mathot Ron A. A., Quaedackers Monique E., Vulto Arnold G., Weimar Willem, van Gelder Teun Inosine monophosphate dehydrogenase messenger RNA expression is correlated to clinical outcomes in mycophenolate mofetil-treated kidney transplant patients, whereas inosine monophosphate dehydrogenase activity is not Therapeutic drug monitoring 2009;31 (5):549-556 [PubMed]
• Sombogaard Ferdi, van Schaik Ron H. N., Mathot Ron A., Budde Klemens, van der Werf Marloes, Vulto Arnold G., Weimar Willem, Glander Petra, Essioux Laurent, van Gelder Teun Interpatient variability in IMPDH activity in MMF-treated renal transplant patients is correlated with IMPDH type II 3757T > C polymorphism Pharmacogenetics and genomics 2009;19 (8):626-634 [PubMed]
• de Winter Brenda C. M., van Gelder Teun, Mathot Ron A. A., Glander Petra, Tedesco-Silva Helio, Hilbrands Luuk, Budde Klemens, van Hest Reinier M. Limited sampling strategies drawn within 3 hours postdose poorly predict mycophenolic acid area-under-the-curve after enteric-coated mycophenolate sodium Therapeutic drug monitoring 2009;31 (5):585-591 [PubMed]
• de Winter Brenda C. M., Neumann Irmgard, van Hest Reinier M., van Gelder Teun, Mathot Ron A. A. Limited sampling strategies for therapeutic drug monitoring of mycophenolate mofetil therapy in patients with autoimmune disease Therapeutic drug monitoring 2009;31 (3):382-390 [PubMed]
• Ahsman Maurice J., Wildschut Enno D., Tibboel Dick, Mathot Ron A. Microanalysis of beta-lactam antibiotics and vancomycin in plasma for pharmacokinetic studies in neonates Antimicrobial agents and chemotherapy 2009;53 (1):75-80 [PubMed]
• van Hest Reinier M., van Gelder Teun, Vulto Arnold G., Shaw Leslie M., Mathot Ron A. A. Pharmacokinetic modelling of the plasma protein binding of mycophenolic acid in renal transplant recipients Clinical pharmacokinetics 2009;48 (7):463-476 [PubMed]
• de Winter Brenda C. M., van Gelder Teun, Sombogaard Ferdi, Shaw Leslie M., van Hest Reinier M., Mathot Ron A. A. Pharmacokinetic role of protein binding of mycophenolic acid and its glucuronide metabolite in renal transplant recipients Journal of pharmacokinetics and pharmacodynamics 2009;36 (6):541-564 [PubMed]

2008

• Schenk P. W., van Fessem M. A. C., Verploegh-van Rij S., Mathot R. A. A., van Gelder T., Vulto A. G., van Vliet M., Lindemans J., Bruijn J. A., van Schaik R. H. N. Association of graded allele-specific changes in CYP2D6 function with imipramine dose requirement in a large group of depressed patients Molecular psychiatry 2008;13 (6):597-605 [PubMed]
• van de Sande Wendy W. J., van Vianen Wim, ten Kate Marian T., Vissers Jolanda, Laurijsens John, Tavakol Mehri, Rijnders Bart J. A., Mathot Ron A. A., Bakker-Woudenberg Irma A. J. M. Caspofungin prolongs survival of transiently neutropenic rats with advanced-stage invasive pulmonary aspergillosis Antimicrobial agents and chemotherapy 2008;52 (4):1345-1350 [PubMed]
• Hunfeld Nicole G., Mathot Ron A., Touw Daan J., van Schaik Ron H., Mulder Paul G., Franck Paul F., Kuipers Ernst J., Geus William P. Effect of CYP2C19*2 and *17 mutations on pharmacodynamics and kinetics of proton pump inhibitors in Caucasians British journal of clinical pharmacology 2008;65 (5):752-760 [PubMed]
• Prins Sandra A., van Dijk Monique, van Leeuwen Pim, Searle Susan, Anderson Brian J., Tibboel Dick, Mathot Ron A. A. Pharmacokinetics and analgesic effects of intravenous propacetamol vs rectal paracetamol in children after major craniofacial surgery Paediatric anaesthesia 2008;18 (7):582-592 [PubMed]
• de Winter Brenda C. M., van Gelder Teun, Glander Petra, Cattaneo Dario, Tedesco-Silva Helio, Neumann Irmgard, Hilbrands Luuk, van Hest Reinier M., Pescovitz Mark D., Budde Klemens, Mathot Ron A. A. Population pharmacokinetics of mycophenolic acid : a comparison between enteric-coated mycophenolate sodium and mycophenolate mofetil in renal transplant recipients Clinical pharmacokinetics 2008;47 (12):827-838 [PubMed]

2007

• Engels Frederike K., Mathot Ron A. A., Verweij Jaap Alternative drug formulations of docetaxel: a review Anti-cancer drugs 2007;18 (2):95-103 [PubMed]
• van Hest Reinier M. Individualisation of mycophenolate mofetil therapy 2007. 221p. ISBN 9789090213781. [UvA Dissertations Online] Erasmus University Rotterdam. (Supervisor: Vulto A. G.; Co-supervisors: Mathôt R. A. A., van Gelder T.)
• Engels Frederike K., Loos Walter J., Mathot Ron A. A., van Schaik Ron H. N., Verweij Jaap Influence of ketoconazole on the fecal and urinary disposition of docetaxel Cancer chemotherapy and pharmacology 2007;60 (4):569-579 [PubMed]
• de Jong Floris A., van der Bol Jessica M., Mathijssen Ron H. J., Loos Walter J., Mathôt Ron A. A., Kitzen Jos J. E. M., van den Bent Martin J., Verweij Jaap Irinotecan chemotherapy during valproic acid treatment: pharmacokinetic interaction and hepatotoxicity Cancer biology & therapy 2007;6 (9):1368-1374 [PubMed]
• Engels Frederike K., de Jong Floris A., Sparreboom Alex, Mathot Ron A. A., Loos Walter J., Kitzen Jos J. E. M., de Bruijn Peter, Verweij Jaap, Mathijssen Ron H. J. Medicinal cannabis does not influence the clinical pharmacokinetics of irinotecan and docetaxel oncologist 2007;12 (3):291-300 [PubMed]
• Bartels P. A., Hanff L. M., Mathot R. A. A., Steegers E. A. P., Vulto A. G., Visser W. Nicardipine in pre-eclamptic patients: placental transfer and disposition in breast milk BJOG 2007;114 (2):230-233 [PubMed]
• Vinks Alexander A., van Rossem Ronald N., Mathôt Ron A. A., Heijerman Harry G. M., Mouton Johan W. Pharmacokinetics of aztreonam in healthy subjects and patients with cystic fibrosis and evaluation of dose-exposure relationships using monte carlo simulation Antimicrobial agents and chemotherapy 2007;51 (9):3049-3055 [PubMed]
• van Hest Reinier M., Doorduijn Jeanette K., de Winter Brenda C. M., Cornelissen Jan J., Vulto Arnold G., Oellerich Michael, Löwenberg Bob, Mathot Ron A. A., Armstrong Victor William, van Gelder Teun Pharmacokinetics of mycophenolate mofetil in hematopoietic stem cell transplant recipients Therapeutic drug monitoring 2007;29 (3):353-360 [PubMed]
• de Winter Brenda C. M., Mathôt Ron A. A., van Hest Reinier M., van Gelder Teun Therapeutic drug monitoring of mycophenolic acid: does it improve patient outcome? Expert opinion on drug metabolism & toxicology 2007;3 (2):251-261 [PubMed]
• van den Broek Walter W., Birkenhäger Tom K., Mulder Paul G. H., Mathot Ron A. A., Bruijn Jan A., Moleman Peter Time-dependent clearance decrements of fluvoxamine in depressed inpatients: a clinical evaluation Journal of clinical psychopharmacology 2007;27 (2):231-233 [PubMed]
• van Hest Reinier M., van Gelder Teun, Bouw René, Goggin Timothy, Gordon Robert, Mamelok Richard D., Mathot Ron A. Time-dependent clearance of mycophenolic acid in renal transplant recipients British journal of clinical pharmacology 2007;63 (6):741-752 [PubMed]

2006

• van Vianen Wim, de Marie Siem, ten Kate Marian T., Mathot Ron A. A., Bakker-Woudenberg Irma A. J. M. Caspofungin: antifungal activity in vitro, pharmacokinetics, and effects on fungal load and animal survival in neutropenic rats with invasive pulmonary aspergillosis Journal of antimicrobial chemotherapy 2006;57 (4):732-740 [PubMed]
• van Hest Reinier M., Mathot Ron A. A., Pescovitz Mark D., Gordon Robert, Mamelok Richard D., van Gelder Teun Explaining variability in mycophenolic acid exposure to optimize mycophenolate mofetil dosing: a population pharmacokinetic meta-analysis of mycophenolic acid in renal transplant recipients Journal of the American Society of Nephrology 2006;17 (3):871-880 [PubMed]
• van Hest Reinier M., Hesselink Dennis A., Vulto Arnold G., Mathot Ron A. A., van Gelder Teun Individualization of mycophenolate mofetil dose in renal transplant recipients Expert opinion on pharmacotherapy 2006;7 (4):361-376 [PubMed]
• Engels Frederike K., Mathot Ron A. A., Loos Walter J., van Schaik Ron H. N., Verweij Jaap Influence of high-dose ketoconazole on the pharmacokinetics of docetaxel Cancer biology & therapy 2006;5 (7):833-839 [PubMed]
• Engels Frederike K. Pharmacokinetic optimization of docetaxel dosing 2006. 164p. ISBN 9789085592433. [UvA Dissertations Online] Erasmus University Rotterdam. (Supervisor: Verweij J.; Co-supervisor: Mathôt R. A. A.)
• Peeters Mariska Y. M., Prins Sandra A., Knibbe Catherijne A. J., DeJongh Joost, Mathôt Ron A. A., Warris Celesta, van Schaik Ron H. N., Tibboel Dick, Danhof Meindert Pharmacokinetics and pharmacodynamics of midazolam and metabolites in nonventilated infants after craniofacial surgery Anesthesiology 2006;105 (6):1135-1146 [PubMed]
• Crommentuyn Kristel M. L., Scherpbier Henriëtte J., Kuijpers Taco W., Mathôt Ron A. A., Huitema Alwin D. R., Beijnen Jos H. Population pharmacokinetics and pharmacodynamics of nelfinavir and its active metabolite M8 in HIV-1-infected children Pediatric infectious disease journal 2006;25 (6):538-543 [PubMed]
• van Hest Reinier M., Mathot Ron A., Vulto Arnold G., Ijzermans Jan N., van Gelder Teun Within-patient variability of mycophenolic acid exposure: therapeutic drug monitoring from a clinical point of view Therapeutic drug monitoring 2006;28 (1):31-34 [PubMed]

2005

• Hesselink Dennis A., van Hest Reinier M., Mathot Ron A. A., Bonthuis Fred, Weimar Willem, de Bruin Ron W. F., van Gelder Teun Cyclosporine interacts with mycophenolic acid by inhibiting the multidrug resistance-associated protein 2 American journal of transplantation 2005;5 (5):987-994 [PubMed]
• van Rossum Lyonne K., Mathot Ron A. A., Cransberg Karlien, Zietse Robert, Vulto Arnold G. Estimation of the glomerular filtration rate in children: which algorithm should be used? Pediatric nephrology (Berlin, Germany) 2005;20 (12):1769-1775 [PubMed]
• Orlent Hans, Mathot Ron A., van Bommel Eric F., Vulto Arnold G., Schalm Solko W., Brouwer Johannes T. Peginterferon and dose-titrated ribavirin for hepatitis C-associated nephrotic membranoproliferative glomerulonephritis type 1 Digestive diseases and sciences 2005;50 (10):1804-1806 [PubMed]
• van Hest Reinier M., van Gelder Teun, Vulto Arnold G., Mathot Ron A. A. Population pharmacokinetics of mycophenolic acid in renal transplant recipients Clinical pharmacokinetics 2005;44 (10):1083-1096 [PubMed]
• Engels F. K., Sparreboom A., Mathot R. A. A., Verweij J. Potential for improvement of docetaxel-based chemotherapy: a pharmacological review British journal of cancer 2005;93 (2):173-177 [PubMed]
• van Hest Reinier, Mathot Ron, Vulto Arnold, Weimar Willem, van Gelder Teun Predicting the usefulness of therapeutic drug monitoring of mycophenolic acid: a computer simulation Therapeutic drug monitoring 2005;27 (2):163-167 [PubMed]
• van Kesteren Charlotte, Zandvliet Anthe S., Karlsson Mats O., Mathôt Ron A. A., Punt Cornelis J. A., Armand Jean-Pierre, Raymond Eric, Huitema Alwin D. R., Dittrich Christian, Dumez Herlinde, Roché Henri H., Droz Jean-Pierre, Ravic Miroslav, Yule S. Murray, Wanders Jantien, Beijnen Jos H., Fumoleau Pierre, Schellens Jan H. M. Semi-physiological model describing the hematological toxicity of the anti-cancer agent indisulam Investigational new drugs 2005;23 (3):225-234 [PubMed]

2004

• de Jonge Milly E., van den Bongard H. J. G. Desirée, Huitema Alwin D. R., Mathôt Ron A. A., Rosing Hilde, Baas Paul, van Zandwijk Nico, Beijnen Jos H., Schellens Jan H. M. Bayesian pharmacokinetically guided dosing of paclitaxel in patients with non-small cell lung cancer Clinical cancer research 2004;10 (7):2237-2244 [PubMed]
• van den Bongard H. J. G. Desirée, Kemper E. Marleen, van Tellingen Olaf, Rosing Hilde, Mathôt Ron A. A., Schellens Jan H. M., Beijnen Jos H. Development and validation of a method to determine the unbound paclitaxel fraction in human plasma Analytical biochemistry 2004;324 (1):11-15 [PubMed]
• van Hest Reinier M., Mathôt Ron A. A., Vulto Arnold G., Le Meur Yann, van Gelder Teun Mycophenolic acid in diabetic renal transplant recipients: pharmacokinetics and application of a limited sampling strategy Therapeutic drug monitoring 2004;26 (6):620-625 [PubMed]
• van Gelder Teun, Hesselink Dennis A., van Hest Reinier M., Mathôt Ron A. A., van Schaik Ron Pharmacogenetics in immunosuppressive therapy: the best thing since TDM? Therapeutic drug monitoring 2004;26 (4):343-346 [PubMed]
• Kerbusch T., Groenewegen G., Mathôt R. A. A., Herben V. M. M., ten Bokkel Huinink W. W., Swart M., Ambaum B., Rosing H., Jansen S., Voest E. E., Beijnen J. H., Schellens J. H. M. Phase I and pharmacokinetic study of the combination of topotecan and ifosfamide administered intravenously every 3 weeks British journal of cancer 2004;90 (12):2268-2277 [PubMed]
• van Ruth Serge, Mathôt Ron A. A., Sparidans Rolf W., Beijnen Jos H., Verwaal Vic J., Zoetmulder Frans A. N. Population pharmacokinetics and pharmacodynamics of mitomycin during intraoperative hyperthermic intraperitoneal chemotherapy Clinical pharmacokinetics 2004;43 (2):131-143 [PubMed]
• Hesselink Dennis A., van Gelder Teun, van Schaik Ron H. N., Balk Aggie H. M. M., van der Heiden Ilse P., van Dam Thea, van der Werf Marloes, Weimar Willem, Mathot Ron A. A. Population pharmacokinetics of cyclosporine in kidney and heart transplant recipients and the influence of ethnicity and genetic polymorphisms in the MDR-1, CYP3A4, and CYP3A5 genes Clinical pharmacology and therapeutics 2004;76 (6):545-556 [PubMed]
• Hesselink D. A., van Dam T., Metselaar H. J., Balk A. H. M. M., Mathôt R. A. A., Smak Gregoor P. J. H., Weimar W., van Gelder T. The relative importance of cyclosporine exposure in heart, kidney or liver transplant recipients on maintenance therapy Transplant international 2004;17 (9):495-504 [PubMed]

2003

• van Rossum Lyonne K., Mathot Ron A. A., Cransberg Karlien, Vulto Arnold G. Optimal sampling strategies to assess inulin clearance in children by the inulin single-injection method Clinical chemistry 2003;49 (7):1170-1179 [PubMed]
• van Kesteren Ch, Mathôt R. A. A., Beijnen J. H., Schellens J. H. M. Pharmacokinetic-pharmacodynamic guided trial design in oncology Investigational new drugs 2003;21 (2):225-241 [PubMed]
• de Jonge Milly E., Mathôt Ron A. A., van Dam Selma M., Rodenhuis Sjoerd, Beijnen Jos H. Sorption of thiotepa to polyurethane catheter causes falsely elevated plasma levels Therapeutic drug monitoring 2003;25 (3):261-263 [PubMed]
• Kruijtzer C. M. F., Boot H., Beijnen J. H., Lochs H. L., Parnis F. X., Planting A. S. T., Pelgrims J. M. G., Williams R., Mathôt R. A. A., Rosing H., Schot M. E., van Tinteren H., Schellens J. H. M. Weekly oral paclitaxel as first-line treatment in patients with advanced gastric cancer Annals of oncology 2003;14 (2):197-204 [PubMed]
• van Kesteren Ch, de Vooght M. M. M., López-Lázaro L., Mathôt R. A. A., Schellens J. H. M., Jimeno J. M., Beijnen J. H. Yondelis (trabectedin, ET-743): the development of an anticancer agent of marine origin Anti-cancer drugs 2003;14 (7):487-502 [PubMed]

2002

• van den Bongard H. J. G. D., Mathôt R. A. A., van Tellingen O., Schellens J. H. M., Beijnen J. H. A population analysis of the pharmacokinetics of Cremophor EL using nonlinear mixed-effect modelling Cancer chemotherapy and pharmacology 2002;50 (1):16-24 [PubMed]
• Kerbusch Thomas, Mathôt Ron A. A., Otten Hans M. M. B., Meesters Eelco W., van Kan Hendrikus J. M., Schellens Jan H. M., Beijnen Jos H. Bayesian pharmacokinetics of lithium after an acute self-intoxication and subsequent haemodialysis: a case report Pharmacology & toxicology 2002;90 (5):243-245 [PubMed]
• van Kesteren Charlotte, Twelves Chris, Bowman Angela, Hoekman Klaas, López-Lázaro Luis, Jimeno José, Guzman Cecilia, Mathôt Ron A. A., Simpson Andrew, Vermorken Jan B., Smyth John, Schellens Jan H. M., Hillebrand Michel J. X., Rosing Hilde, Beijnen Jos H. Clinical pharmacology of the novel marine-derived anticancer agent Ecteinascidin 743 administered as a 1- and 3-h infusion in a phase I study Anti-cancer drugs 2002;13 (4):381-393 [PubMed]
• van Kesteren Charlotte, Mathôt R. A. A., Raymond E., Armand J. P., Fumoleau P., Punt C., Ravic M., Wanders J., Beijnen J. H., Schellens J. H. M. Development and validation of limited sampling strategies for prediction of the systemic exposure to the novel anticancer agent E7070 (N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide) British journal of clinical pharmacology 2002;54 (5):463-471 [PubMed]
• Schoemaker Nadja E., Mathôt Ron A. A., Schöffski Patrick, Rosing Hilde, Schellens Jan H. M., Beijnen Jos H. Development of an optimal pharmacokinetic sampling schedule for rubitecan administered orally in a daily times five schedule Cancer chemotherapy and pharmacology 2002;50 (6):514-517 [PubMed]
• de Maat Monique M. R., Frankfort Suzanne V., Mathôt Ron A. A., Mulder Jan W., Meenhorst Pieter L., van Gorp Eric C. M., Koks Cornelis H. W., Hoetelmans Richard M. W., de Boer Anthonius, Beijnen Jos H. Discrepancies between medical and pharmacy records for patients on anti-HIV drugs Annals of pharmacotherapy 2002;36 (3):410-415 [PubMed]
• de Jonge Milly E., Mathôt Ron A. A., van Dam Selma M., Beijnen Jos H., Rodenhuis Sjoerd Extremely high exposures in an obese patient receiving high-dose cyclophosphamide, thiotepa and carboplatin Cancer chemotherapy and pharmacology 2002;50 (3):251-255 [PubMed]
• de Maat Monique M. R., Mathôt Ron A. A., Veldkamp Agnes I., Huitma Aldwin D. R., Mulder Jan W., Meenhorst Pieter L., van Gorp Eric C. M., Carlier Hilde, Beijnen Jos H. Hepatotoxicity following nevirapine-containing regimens in HIV-1-infected individuals Pharmacological research 2002;46 (3):295-300 [PubMed]
• Kruijtzer C. M. F., Schellens J. H. M., Mezger J., Scheulen M. E., Keilholz U., Beijnen J. H., Rosing H., Mathôt R. A. A., Marcus S., van Tinteren H., Baas P. Phase II and pharmacologic study of weekly oral paclitaxel plus cyclosporine in patients with advanced non-small-cell lung cancer Journal of clinical oncology 2002;20 (23):4508-4516 [PubMed]
• van Kesteren Charlotte Population pharmacokinetics and pharmacodyanmics of two novel anticancer agents: Ecteinascidin-743 and E7070 2002. 224p. ISBN 9789039330869. [UvA Dissertations Online] Utrecht University. (Supervisors: Beijnen J., Schellens J.; Co-supervisor: Mathôt R. A. A.)
• van Kesteren Ch, Mathôt R. A. A., Raymond E., Armand J. P., Dittrich Ch, Dumez H., Roché H., Droz J. P., Punt C., Ravic M., Wanders J., Beijnen J. H., Fumoleau P., Schellens J. H. M. Population pharmacokinetics of the novel anticancer agent E7070 during four phase I studies: model building and validation Journal of clinical oncology 2002;20 (19):4065-4073 [PubMed]
• Crul Mirjam, Mathôt Ron A., Giaccone Giuseppe, Punt Cornelis A., Rosing Hilde, Hillebrand Michel X., Ando Yoshitaka, Nishi Nobosuke, Tanaka Hideji, Schellens Jan M., Beijnen Jos H. Population pharmacokinetics of the novel anticancer agent KRN7000 Cancer chemotherapy and pharmacology 2002;49 (4):287-293 [PubMed]
• Koks C. H. W., Crommentuyn K. M. L., Mathôt R. A. A., Mulder J. W., Meenhorst P. L., Beijnen J. H. Prognostic factors for the clinical effectiveness of fluconazole in the treatment of oral candidiasis in HIV-1-infected individuals Pharmacological research 2002;46 (1):89-94 [PubMed]
• de Jonge M. E., Mathôt R. A. A., Dalesio O., Huitema A. D. R., Rodenhuis S., Beijnen J. H. Relationship between irreversible alopecia and exposure to cyclophosphamide, thiotepa and carboplatin (CTC) in high-dose chemotherapy Bone marrow transplantation 2002;30 (9):593-597 [PubMed]

2001

• Huitema A. D., Mathôt R. A., Tibben M. M., Rodenhuis S., Beijnen J. H. A mechanism-based pharmacokinetic model for the cytochrome P450 drug-drug interaction between cyclophosphamide and thioTEPA and the autoinduction of cyclophosphamide Journal of pharmacokinetics and pharmacodynamics 2001;28 (3):211-230 [PubMed]
• Koks C. H., Crommentuyn K. M., Hoetelmans R. M., Mathôt R. A., Beijnen J. H. Can fluconazole concentrations in saliva be used for therapeutic drug monitoring? Therapeutic drug monitoring 2001;23 (4):449-453 [PubMed]
• Kerbusch T., Mathôt R. A., Keizer H. J., Kaijser G. P., Schellens J. H., Beijnen J. H. Influence of dose and infusion duration on pharmacokinetics of ifosfamide and metabolites Drug metabolism and disposition: the biological fate of chemicals 2001;29 (7):967-975 [PubMed]
• Kerbusch T., Jansen R. L., Mathôt R. A., Huitema A. D., Jansen M., van Rijswijk R. E., Beijnen J. H. Modulation of the cytochrome P450-mediated metabolism of ifosfamide by ketoconazole and rifampin Clinical pharmacology and therapeutics 2001;70 (2):132-141 [PubMed]
• Huitema A. D. Population pharmacokinetics and pharmacokinetically guided dosing of cyclophosphamide, thioTEPA and carboplatin in high-dose chemotherapy 2001. 246p. ISBN 9789039326336. [UvA Dissertations Online] Utrecht University. (Supervisors: Beijnen J., Rodenhuis S.; Co-supervisor: Mathôt R. A. A.)
• Huitema A. D., Mathôt R. A., Tibben M. M., Schellens J. H., Rodenhuis S., Beijnen J. H. Population pharmacokinetics of thioTEPA and its active metabolite TEPA in patients undergoing high-dose chemotherapy British journal of clinical pharmacology 2001;51 (1):61-70 [PubMed]
• van den Bongard H. J. G. Desirée, Mathôt Ron A. A., Boogerd Willem, Schornagel Jan H., Soesan Marcel, Schellens Jan H. M., Beijnen Jos H. Successful rescue with leucovorin and thymidine in a patient with high-dose methotrexate induced acute renal failure Cancer chemotherapy and pharmacology 2001;47 (6):537-540 [PubMed]
• Koks C. H., Crommentuyn K. M., Hoetelmans R. M., Burger D. M., Koopmans P. P., Mathôt R. A., Mulder J. W., Meenhorst P. L., Beijnen J. H. The effect of fluconazole on ritonavir and saquinavir pharmacokinetics in HIV-1-infected individuals British journal of clinical pharmacology 2001;51 (6):631-635 [PubMed]
• Huitema A. D., Mathôt R. A., Tibben M. M., Rodenhuis S., Beijnen J. H. Validation of a therapeutic drug monitoring strategy for thiotepa in a high-dose chemotherapy regimen Therapeutic drug monitoring 2001;23 (6):650-657 [PubMed]

2000

• Kerbusch Thomas Clinical pharmacology of ifosfamide and metabolites 2000. 231p. ISBN 9789039325629. [UvA Dissertations Online] Utrecht University. (Supervisors: Beijnen J., Schellens J.; Co-supervisor: Mathôt R. A. A.)
• Kerbusch T., Huitema A. D., Ouwerkerk J., Keizer H. J., Mathôt R. A., Schellens J. H., Beijnen J. H. Evaluation of the autoinduction of ifosfamide metabolism by a population pharmacokinetic approach using NONMEM British journal of clinical pharmacology 2000;49 (6):555-561 [PubMed]
• Geus W. P., Mathôt R. A., Mulder P. G., Lamers C. B. Pharmacodynamics and kinetics of omeprazole MUPS 20 mg and pantoprazole 40 mg during repeated oral administration in Helicobacter pylori-negative subjects Alimentary pharmacology & therapeutics 2000;14 (8):1057-1064 [PubMed]
• van den Bongard H. J., Mathôt R. A., Beijnen J. H., Schellens J. H. Pharmacokinetically guided administration of chemotherapeutic agents Clinical pharmacokinetics 2000;39 (5):345-367 [PubMed]
• Huitema A. D., Smits K. D., Mathôt R. A., Schellens J. H., Rodenhuis S., Beijnen J. H. The clinical pharmacology of alkylating agents in high-dose chemotherapy Anti-cancer drugs 2000;11 (7):515-533 [PubMed]
• Huitema A. D., Mathôt R. A., Tibben M. M., Schellens J. H., Rodenhuis S., Beijnen J. H. Validation of techniques for the prediction of carboplatin exposure: application of Bayesian methods Clinical pharmacology and therapeutics 2000;67 (6):621-630 [PubMed]

1999

• van Lent-Evers N. A., Mathôt R. A., Geus W. P., van Hout B. A., Vinks A. A. Impact of goal-oriented and model-based clinical pharmacokinetic dosing of aminoglycosides on clinical outcome: a cost-effectiveness analysis Therapeutic drug monitoring 1999;21 (1):63-73 [PubMed]
• Mathôt R. A., Geus W. P. Pharmacodynamic modeling of the acid inhibitory effect of ranitidine in patients in an intensive care unit during prolonged dosing: characterization of tolerance Clinical pharmacology and therapeutics 1999;66 (2):140-151 [PubMed]

1997

• van Schaick E. A., Kulkarni C., von Frijtag Drabbe Künzel J. K., Mathôt R. A., Cristalli G., IJzerman A. P., Danhof M. Time course of action of three adenosine A1 receptor agonists with differing lipophilicity in rats: comparison of pharmacokinetic, haemodynamic and EEG effects Naunyn-Schmiedeberg s archives of pharmacology 1997;356 (6):827-837 [PubMed]

1996

• Roelen H., Veldman N., Spek A. L., von Frijtag Drabbe Künzel J., Mathôt R. A., IJzerman A. P. N6,C8-distributed adenosine derivatives as partial agonists for adenosine A1 receptors Journal of medicinal chemistry 1996;39 (7):1463-1471 [PubMed]
• Mathot R. A., Wenden E. M., Soudijn W., Breimer D. D., IJzerman A. P., Danhof M. Partial agonism of the nonselective adenosine receptor agonist 8-butylaminoadenosine at the A1 receptor in vivo Journal of pharmacology and experimental therapeutics 1996;279 (3):1439-1446 [PubMed]

1995

• van der Wenden E. M., Hartog-Witte H. R., Roelen H. C., von Frijtag Drabbe Künzel J. K., Pirovano I. M., Mathôt R. A., Danhof M., van Aerschot A., Lidaks M. J., IJzerman A. P. 8-substituted adenosine and theophylline-7-riboside analogues as potential partial agonists for the adenosine A1 receptor European journal of pharmacology 1995;290 (3):189-199 [PubMed]
• Mathôt R. A., van der Wenden E. M., Soudijn W., IJzerman A. P., Danhof M. Deoxyribose analogues of N6-cyclopentyladenosine (CPA): partial agonists at the adenosine A1 receptor in vivo British journal of pharmacology 1995;116 (3):1957-1964 [PubMed]
• Appel S., Mathôt R. A., Langemeijer M. W., IJzerman A. P., Danhof M. Modelling of the pharmacodynamic interaction of an A1 adenosine receptor agonist and antagonist in vivo: N6-cyclopentyladenosine and 8-cyclopentyltheophylline British journal of pharmacology 1995;115 (7):1253-1259 [PubMed]
• Mathôt R. A., Cleton A., Soudijn W., IJzerman A. P., Danhof M. Pharmacokinetic modelling of the haemodynamic effects of the A2a adenosine receptor agonist CGS 21680C in conscious normotensive rats British journal of pharmacology 1995;114 (4):761-768 [PubMed]
• Mathôt R. A., van den Aarsen B. C., Soudijn W., Breimer D. D., IJzerman A. P., Danhof M. Pharmacokinetic-pharmacodynamic modelling of the cardiovascular effects of R- and S-N6-phenylisopropyladenosine in conscious normotensive rats Journal of pharmacology and experimental therapeutics 1995;273 (1):405-414 [PubMed]
• Mathôt R. A., Gubbens-Stibbe J. M., Soudijn W., Jacobson K. A., IJzerman A. P., Danhof M. Quantification of the in vivo potency of the adenosine A2 receptor antagonist 8-(3-chlorostyryl)caffeine Journal of pharmacology and experimental therapeutics 1995;275 (1):245-253 [PubMed]
• van der Wenden E. M., von Frijtag Drabbe Künzel J. K., Mathôt R. A., Danhof M., IJzerman A. P., Soudijn W. Ribose-modified adenosine analogues as potential partial agonists for the adenosine receptor Journal of medicinal chemistry 1995;38 (20):4000-4006 [PubMed]

1994

• Mathôt R. A., van den Aarsen B. C., von Frijtag Drabble Künzel J. K., Danhof M., IJzerman A. P. Assessment of the enantiomeric purity of R- and S-N6-phenylisopropyladenosine (PIA): implications for adenosine receptor subclassification Naunyn-Schmiedeberg s archives of pharmacology 1994;350 (1):109-112 [PubMed]
• Irth H., Cleton A., Mathôt R. A., Danhof M., IJzerman A. P., Tjaden U. R., van der Greef J. Liquid chromatographic determination of the adenosine receptor agonist CGS 21680 in blood using on-line solid-phase extraction on a phenylboronic acid support and fluorescence detection Journal of chromatography. B, Biomedical applications 1994;658 (1):207-212 [PubMed]
• IJzerman A. P., van der Wenden E. M., von Frijtag Drabbe Künzel J. K., Mathôt R. A., Danhof M., Borea P. A., Varani K. Partial agonism of theophylline-7-riboside on adenosine receptors Naunyn-Schmiedeberg s archives of pharmacology 1994;350 (6):638-645 [PubMed]
• Mathôt R. A., van Schaick E. A., Langemeijer M. W., Soudijn W., Breimer D. D., IJzerman A. P., Danhof M. Pharmacokinetic-pharmacodynamic relationship of the cardiovascular effects of adenosine A1 receptor agonist N6-cyclopentyladenosine in the rat Journal of pharmacology and experimental therapeutics 1994;268 (2):616-624 [PubMed]

1993

• Mathôt R. A., Appel S., van Schaick E. A., Soudijn W., IJzerman A. P., Danhof M. High-performance liquid chromatography of the adenosine A1 agonist N6-cyclopentyladenosine and the A1 antagonist 8-cyclopentyltheophylline and its application in a pharmacokinetic study in rats Journal of chromatography. A 1993;620 (1):113-120 [PubMed]
• Danhof M., Mandema J. W., Hoogerkamp A., Mathôt R. A. Pharmacokinetic-pharmacodynamic modelling in pre-clinical investigations: principles and perspectives European journal of drug metabolism and pharmacokinetics 1993;18 (1):41-47 [PubMed]

1989

• van Hoogdalem E. J., Heijligers-Feijen C. D., Mathôt R. A., Wackwitz A. T., van Bree J. B., Verhoef J. C., de Boer A. G., Breimer D. D. Rectal absorption enhancement of cefoxitin and desglycinamide arginine vasopressin by sodium tauro-24,25-dihydrofusidate in conscious rats Journal of pharmacology and experimental therapeutics 1989;251 (2):741-744 [PubMed]