Prof. V.M. Christoffels PhD publications

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Publications Prof. PhD V.M. Christoffels

Position
Full Professor
Main activities
Education, Research, Other
Specialisation
developmental biology, molecular biology, heart development
Focus of research
  • Developmental biology
  • Heart development
  • Transcriptional regulation
  • Epigenetics
  • Congenital heart defects
  • Conduction system
  • Sinoatrial node
  • Arrhythmias
  • Transgenic mice
  • Lineage analysis
Amsterdam UMC Research Institutes
AMC departments
All publications

2021

  • Man Joyce C. K., van Duijvenboden Karel, Krijger Peter H. L., Hooijkaas Ingeborg B., van der Made Ingeborg, de Gier-de Vries Corrie, Wakker Vincent, Creemers Esther E., de Laat Wouter, Boukens Bastiaan J., Christoffels Vincent M. Genetic Dissection of a Super Enhancer Controlling the Nppa-Nppb Cluster in the Heart Circulation research 2021;128 (1):115-129 [PubMed]
  • van Walree Eva S., Dombrowsky Gregor, Jansen Iris E., Mirkov Maša Umićević, Zwart Rob, Ilgun Aho, Guo Dongchuan, Clur Sally-Ann B., Amin Ahmed S., Savage Jeanne E., van der Wal Allard C., Waisfisz Quinten, Maugeri Alessandra, Wilsdon Anna, Bu’Lock Frances A., Hurles Matthew E., Dittrich Sven, Berger Felix, Audain Martinez Enrique, Christoffels Vincent M., Hitz Marc-Philip, Milewicz Dianna M., Posthuma Daniëlle, Meijers-Heijboer Hanne, Postma Alex V., Mathijssen Inge B. Germline variants in HEY2 functional domains lead to congenital heart defects and thoracic aortic aneurysms Genetics in medicine 2021;23 (1):103-110 [PubMed]
  • Medzikovic Lejla, Heese Hylja, van Loenen Pieter B., van Roomen Cindy P. A. A., Hooijkaas Ingeborg B., Christoffels Vincent M., Creemers Esther E., de Vries Carlie J. M., de Waard Vivian Nuclear receptor nur77 controls cardiac fibrosis through distinct actions on fibroblasts and cardiomyocytes International journal of molecular sciences 2021;22 (4):1-16 [PubMed]
  • Végh Anna M. D., Verkerk Arie O., Cócera Ortega Lucía, Wang Jianan, Geerts Dirk, Klerk Mischa, Lodder Kirsten, Nobel Ruby, Tijsen Anke J., Devalla Harsha D., Christoffels Vincent M., Medina-Ramírez Max, Smits Anke M., Tan Hanno L., Wilders Ronald, Goumans Marie José T. H., Boink Gerard J. J. Toward Biological Pacing by Cellular Delivery of Hcn2/SkM1 Frontiers in physiology 2021;11 [PubMed]

2020

  • Jensen Bjarke, Christoffels Vincent M., Moorman Antoon F. M. An appreciation of anatomy in the molecular world Journal of cardiovascular development and disease 2020;7 (4):1-15 [PubMed]
  • Christoffels Vincent, Jensen Bjarke Cardiac morphogenesis: Specification of the four-chambered heart Cold Spring Harbor perspectives in biology 2020;12 (10):1-18 [PubMed]
  • van Ouwerkerk Antoinette F, Hall Amelia W, Kadow Zachary A, Lazarevic Sonja, Reyat Jasmeet S, Tucker Nathan R, Nadadur Rangarajan D, Bosada Fernanda M, Bianchi Valerio, Ellinor Patrick T, Fabritz Larissa, Martin James F, de Laat Wouter, Kirchhof Paulus, Moskowitz Ivan P, Christoffels Vincent M Epigenetic and Transcriptional Networks Underlying Atrial Fibrillation Circulation research 2020;127 (1):34-50 [PubMed]
  • Fiore Roberto, Rahim Belquis, Christoffels Vincent M., Moorman Antoon F. M., Püschel Andreas W. Erratum: Inactivation of the Sema5a gene results in embryonic lethality and defective remodeling of the cranial vascular system (Molecular and Cellular Biology (2005) 25:6 (2314) DOI: 10.1128/MCB.25.6.2310-2319.2005) Molecular and cellular biology 2020;40 (20) [PubMed]
  • van Eif Vincent W. W., Protze Stephanie I., Bosada Fernanda M., Yuan Xuefei, Sinha Tanvi, van Duijvenboden Karel, Ernault Auriane C., Mohan Rajiv A., Wakker Vincent, de Gier-de Vries Corrie, Hooijkaas Ingeborg B., Wilson Michael D., Verkerk Arie O., Bakkers Jeroen, Boukens Bastiaan J., Black Brian L., Scott Ian C., Christoffels Vincent M. Genome-Wide Analysis Identifies an Essential Human TBX3 Pacemaker Enhancer Circulation research 2020;127 (12):1522-1535 [PubMed]
  • van Eif Vincent W. W., Stefanovic Sonia, Mohan Rajiv A., Christoffels Vincent M. Gradual differentiation and confinement of the cardiac conduction system as indicated by marker gene expression BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 2020;1867 (3) [PubMed]
  • van Ouwerkerk Antoinette F., Bosada Fernanda M., Liu Jia, Zhang Juan, van Duijvenboden Karel, Chaffin Mark, Tucker Nathan R., Pijnappels Daniel, Ellinor Patrick T., Barnett Phil, de Vries Antoine A. F., Christoffels Vincent M. Identification of Functional Variant Enhancers Associated with Atrial Fibrillation Circulation research 2020;127 (2):229-243 [PubMed]
  • Mohan Rajiv A. Origin and transcriptional control of the cardiac conduction system 2020. 240p. ISBN 9789493197008. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Christoffels Vincent M.; Co-supervisors: Boukens Bas J. D., Postma Alex V.)
  • Jensen Bjarke, Christoffels Vincent M. Reptiles as a model system to study heart development Cold Spring Harbor perspectives in biology 2020;12 (5) [PubMed]
  • Mohan Rajiv A., Bosada Fernanda M., van Weerd Jan H., van Duijvenboden Karel, Wang Jianan, Mommersteeg Mathilda T. M., Hooijkaas Ingeborg B., Wakker Vincent, de Gier-de Vries Corrie, Coronel Ruben, Boink Gerard J. J., Bakkers Jeroen, Barnett Phil, Boukens Bas J., Christoffels Vincent M. T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system Proceedings of the National Academy of Sciences of the United States of America 2020;117 (31):18617-18626 [PubMed]
  • Kvasilova Alena, Olejnickova Veronika, Jensen Bjarke, Christoffels Vincent M., Kolesova Hana, Sedmera David, Gregorovicova Martina The formation of the atrioventricular conduction axis is linked in development to ventricular septation Journal of experimental biology 2020;223 [PubMed]
  • van Weerd Jan Hendrik, Mohan Rajiv A., van Duijvenboden Karel, Hooijkaas Ingeborg B., Wakker Vincent, Boukens Bastiaan J., Barnett Phil, Christoffels Vincent M. Trait-associated noncoding variant regions affect TBX3 regulation and cardiac conduction eLife 2020;9:1-26 [PubMed]
  • van Weerd J. H. Transcriptional control of cardiac conduction system development and function 2020. 241p. ISBN 9789493197060. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Christoffels Vincent M.; Co-supervisor: Barnett Phil)

2019

  • Man Joyce C K, Mohan Rajiv A, Boogaard Malou van den, Hilvering Catharina R E, Jenkins Catherine, Wakker Vincent, Bianchi Valerio, Laat Wouter de, Barnett Phil, Boukens Bastiaan J, Christoffels Vincent M An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo Nature communications 2019;10 (1):4943 [PubMed]
  • Végh Anna M. D., Dénise den Haan A., Ortega Lucía C. cera, Verkerk Arie O., Sluijter Joost P. G., Bakker Diane, van Amersfoorth Shirley, van Veen Toon A. B., Klerk Mischa, Seppen Jurgen, de Bakker Jacques M. T., Christoffels Vincent M., Geerts Dirk, Goumans Marie José T. H., Tan Hanno L., Boink Gerard J. J. Cardiomyocyte progenitor cells as a functional gene delivery vehicle for long-term biological pacing Molecules 2019;24 (1) [PubMed]
  • Kroneman Jelle G H, Faber Jaeike W, Schouten Jacobine C M, Wolschrijn Claudia F, Christoffels Vincent M, Jensen Bjarke Comparative analysis of avian hearts provides little evidence for variation among species with acquired endothermy Journal of morphology 2019;280 (3):395-410 [PubMed]
  • van Duijvenboden Karel, de Bakker Dennis E. M., Man Joyce C. K., Janssen Rob, Günthel Marie, Hill Matthew C., Hooijkaas Ingeborg B., van der Made Ingeborg, van der Kraak Petra H., Vink Aryan, Creemers Esther E., Martin James F., Barnett Phil, Bakkers Jeroen, Christoffels Vincent M. Conserved NPPB+ Border Zone Switches From MEF2- to AP-1-Driven Gene Program Circulation 2019;140 (10):864-879 [PubMed]
  • van Duijvenboden Karel Deciphering the regulome of the heart 2019. 221p. ISBN 9789463752862. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Christoffels V. M.; Co-supervisor: Ruijter J. M.)
  • Mattiotti Andrea Follistatin-like 1 in development and disease 2019. 229p. ISBN 9789462997318. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Christoffels V. M.; Co-supervisor: van den Hoff M. J. B.)
  • van den Boogaard M., van Weerd Jan Hendrik, Bawazeer Amira C., Hooijkaas Ingeborg B., van de Werken Harmen J. G., Tessadori Federico, de Laat Wouter, Barnett Phil, Bakkers Jeroen, Christoffels Vincent M. Identification and Characterization of a Transcribed Distal Enhancer Involved in Cardiac Kcnh2 Regulation Cell reports 2019;28 (10):2704-2714.e5 [PubMed]
  • van Ouwerkerk Antoinette F., Bosada Fernanda M., van Duijvenboden Karel, Hill Matthew C., Montefiori Lindsey E., Scholman Koen T., Liu Jia, de Vries Antoine A. F., Boukens Bastiaan J., Ellinor Patrick T., Goumans Marie José T. H., Efimov Igor R., Nobrega Marcelo A., Barnett Phil, Martin James F., Christoffels Vincent M. Identification of atrial fibrillation associated genes and functional non-coding variants Nature communications 2019;10 (1) [PubMed]
  • Hanemaaijer Jermo, Gregorovicova Martina, Nielsen Jan M., Moorman Antoon F. M., Wang Tobias, Planken R. Nils, Christoffels Vincent M., Sedmera David, Jensen Bjarke Identification of the building blocks of ventricular septation in monitor lizards (Varanidae) Development (Cambridge, England) 2019;146 (14) [PubMed]
  • Houweling Arjan C., Beaman Glenda M., Postma Alex V., Blair Gainous T., Lichtenbelt Klaske D., Brancati Francesco, Lopes Filipa M., van der Made Ingeborg, Polstra Abeltje M., Robinson Michael L., Wright Kevin D., Ellingford Jamie M., Jackson Ashley R., Overwater Eline, Genesio Rita, Romano Silvio, Camerota Letizia, D'Angelo Emanuela, Meijers-Heijboer Elizabeth J., Christoffels Vincent M., McHugh Kirk M., Black Brian L., Newman William G., Woolf Adrian S., Creemers Esther E. Loss-of-function variants in myocardin cause congenital megabladder in humans and mice Journal of clinical investigation 2019;129 (12):5374-5380 [PubMed]
  • Jensen Bjarke, Joyce William, Gregorovicova Martina, Sedmera David, Wang Tobias, Christoffels Vincent M. Low incidence of atrial septal defects in nonmammalian vertebrates Evolution and Development 2019 [PubMed]
  • Faber Jaeike W, Boukens Bastiaan J, Oostra Roelof-Jan, Moorman Antoon F M, Christoffels Vincent M, Jensen Bjarke Sinus venosus incorporation: contentious issues and operational criteria for developmental and evolutionary studies Journal of anatomy 2019;234 (5):583-591 [PubMed]
  • Wojahn Irina, Lüdtke Timo H., Christoffels Vincent M., Trowe Mark-Oliver, Kispert Andreas TBX2-positive cells represent a multi-potent mesenchymal progenitor pool in the developing lung Respiratory research 2019;20 (1) [PubMed]
  • Prakash Stuti The role of Follistatin-like 1 (Fstl1) in the developing heart 2019. 245p. ISBN 9789463752268. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Christoffels V. M.; Co-supervisor: van den Hoff M. J. B.)
  • van Eif Vincent W. W., Stefanovic Sonia, van Duijvenboden Karel, Bakker Martijn, Wakker Vincent, de Gier-de Vries Corrie, Zaffran Stéphane, Verkerk Arie O., Boukens Bas J., Christoffels Vincent M. Transcriptome analysis of mouse and human sinoatrial node cells reveals a conserved genetic program Development (Cambridge, England) 2019;146 (8) [PubMed]
  • Vincentz Joshua W., Firulli Beth A., Toolan Kevin P., Arking Dan E., Sotoodehnia Nona, Wan Juyi, Chen Peng-Sheng, de Gier-de Vries Corrie, Christoffels Vincent M., Rubart-von der Lohe Michael, Firulli Anthony B. Variation in a Left Ventricle-Specific Hand1 Enhancer Impairs GATA Transcription Factor Binding and Disrupts Conduction System Development and Function Circulation research 2019;125 (6):575-589 [PubMed]

2018

  • Ferrer Christina M., Alders Marielle, Postma Alex V., Park Seonmi, Klein Mark A., Cetinbas Murat, Pajkrt Eva, Glas Astrid, van Koningsbruggen Silvana, Christoffels Vincent M., Mannens Marcel M. A. M., Knegt Lia, Etchegaray Jean-Pierre, Sadreyev Ruslan I., Denu John M., Mostoslavsky Gustavo, van Maarle Merel C., Mostoslavsky Raul An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality Genes & development 2018;32 (5-6):373-388 [PubMed]
  • Mohan Rajiv A., Boukens Bastiaan J., Christoffels Vincent M. Developmental Origin of the Cardiac Conduction System: Insight from Lineage Tracing Pediatric cardiology 2018;39 (6):1107-1114 [PubMed]
  • Günthel Marie, Barnett Phil, Christoffels Vincent M. Development, Proliferation, and Growth of the Mammalian Heart Molecular therapy 2018;26 (7):1599-1609 [PubMed]
  • Adepu Saritha, Oosterwerff Erik F J, Christoffels Vincent M, Boink Gerard J J Direct Reprograming to Regenerate Myocardium and Repair Its Pacemaker and Conduction System Medicines (Basel, Switzerland) 2018;5 (2) [PubMed]
  • Mohan Rajiv A., Mommersteeg Mathilda T. M., Domínguez Jorge N., Choquet Caroline, Wakker Vincent, de Gier-de Vries Corrie, Boink Gerard J. J., Boukens Bastiaan J., Miquerol Lucile, Verkerk Arie O., Christoffels Vincent M. Embryonic Tbx3+ cardiomyocytes form the mature cardiac conduction system by progressive fate restriction Development (Cambridge, England) 2018;145 (17) [PubMed]
  • Jensen Bjarke, Boukens Bastiaan J, Crossley Dane A, Conner Justin, Mohan Rajiv A, van Duijvenboden Karel, Postma Alex V, Gloschat Christopher R, Elsey Ruth M, Sedmera David, Efimov Igor R, Christoffels Vincent M Specialized impulse conduction pathway in the alligator heart eLife 2018;7 [PubMed]
  • Man Joyce, Barnett Phil, Christoffels Vincent M. Structure and function of the Nppa-Nppb cluster locus during heart development and disease Cellular and molecular life sciences 2018;75 (8):1435-1444 [PubMed]
  • Aydoğdu Nurullah, Rudat Carsten, Trowe Mark-Oliver, Kaiser Marina, Lüdtke Timo H., Taketo Makoto Mark, Christoffels Vincent M., Moon Anne, Kispert Andreas TBX2 and TBX3 act downstream of canonical WNT signaling in patterning and differentiation of the mouse ureteric mesenchyme Development (Cambridge, England) 2018;145 (23) [PubMed]
  • van Eif Vincent W. W., Devalla Harsha D., Boink Gerard J. J., Christoffels Vincent M. Transcriptional regulation of the cardiac conduction system Nature reviews. Cardiology 2018;15 (10):617-630 [PubMed]

2017

  • Anas Adam A., Claushuis Theodora A. M., Mohan Rajiv A., Christoffels Vincent M., Aidinis Vassilis, Florquin Sandrine, van't Veer Cornelis, Hou Baidong, de Vos Alex F., van der Poll Tom Epithelial Myeloid-Differentiation Factor 88 Is Dispensable during Klebsiella Pneumonia American journal of respiratory cell and molecular biology 2017;56 (5):648-656 [PubMed]
  • Jensen Bjarke, van der Wal Allard C., Moorman Antoon F. M., Christoffels Vincent M. Excessive trabeculations in noncompaction do not have the embryonic identity International journal of cardiology 2017;227:325-330 [PubMed]
  • Mohan Rajiv, Boukens Bas J., Christoffels Vincent M. Lineages of the Cardiac Conduction System Journal of cardiovascular development and disease 2017;4 (2) [PubMed]
  • Jensen Bjarke, Vesterskov Signe, Boukens Bastiaan J., Nielsen Jan M., Moorman Antoon F. M., Christoffels Vincent M., Wang Tobias Morpho-functional characterization of the systemic venous pole of the reptile heart Scientific reports 2017;7 (1) [PubMed]
  • Burkhard Silja, van Eif Vincent, Garric Laurence, Christoffels Vincent M., Bakkers Jeroen On the Evolution of the Cardiac Pacemaker Journal of cardiovascular development and disease 2017;4 (2) [PubMed]
  • Woudstra Odilia I., Ahuja Suchit, Bokma Jouke P., Bouma Berto J., Mulder Barbara J. M., Christoffels Vincent M. Origins and consequences of congenital heart defects affecting the right ventricle Cardiovascular research 2017;113 (12):1509-1520 [PubMed]
  • van den Boogaard Malou Transcriptional control of ion channel genes in arrhythmogenesis 2017. 247p. ISBN 9789082488722. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Christoffels V. M.; Co-supervisor: Barnett P.)

2016

  • van der Harst Pim, van Setten Jessica, Verweij Niek, Vogler Georg, Franke Lude, Maurano Matthew T., Wang Xinchen, Mateo Leach Irene, Eijgelsheim Mark, Sotoodehnia Nona, Hayward Caroline, Sorice Rossella, Meirelles Osorio, Lyytikäinen Leo-Pekka, Polašek Ozren, Tanaka Toshiko, Arking Dan E., Ulivi Sheila, Trompet Stella, Müller-Nurasyid Martina, Smith Albert V., Dörr Marcus, Kerr Kathleen F., Magnani Jared W., del Greco M Fabiola, Zhang Weihua, Nolte Ilja M., Silva Claudia T., Padmanabhan Sandosh, Tragante Vinicius, Esko Tõnu, Abecasis Gonçalo R., Adriaens Michiel E., Andersen Karl, Barnett Phil, Bis Joshua C., Bodmer Rolf, Buckley Brendan M., Campbell Harry, Cannon Megan V., Chakravarti Aravinda, Chen Lin Y., Delitala Alessandro, Devereux Richard B., Doevendans Pieter A., Dominiczak Anna F., Ferrucci Luigi, Ford Ian, Gieger Christian, Harris Tamara B., Haugen Eric, Heinig Matthias, Hernandez Dena G., Hillege Hans L., Hirschhorn Joel N., Hofman Albert, Hubner Norbert, Hwang Shih-Jen, Iorio Annamaria, Kähönen Mika, Kellis Manolis, Kolcic Ivana, Kooner Ishminder K., Kooner Jaspal S., Kors Jan A., Lakatta Edward G., Lage Kasper, Launer Lenore J., Levy Daniel, Lundby Alicia, Macfarlane Peter W., May Dalit, Meitinger Thomas, Metspalu Andres, Nappo Stefania, Naitza Silvia, Neph Shane, Nord Alex S., Nutile Teresa, Okin Peter M., Olsen Jesper V., Oostra Ben A., Penninger Josef M., Pennacchio Len A., Pers Tune H., Perz Siegfried, Peters Annette, Pinto Yigal M., Pfeufer Arne, Pilia Maria Grazia, Pramstaller Peter P., Prins Bram P., Raitakari Olli T., Raychaudhuri Soumya, Rice Ken M., Rossin Elizabeth J., Rotter Jerome I., Schafer Sebastian, Schlessinger David, Schmidt Carsten O., Sehmi Jobanpreet, Silljé Herman H. W., Sinagra Gianfranco, Sinner Moritz F., Slowikowski Kamil, Soliman Elsayed Z., Spector Timothy D., Spiering Wilko, Stamatoyannopoulos John A., Stolk Ronald P., Strauch Konstantin, Tan Sian-Tsung, Tarasov Kirill V., Trinh Bosco, Uitterlinden Andre G., van den Boogaard Malou, van Duijn Cornelia M., van Gilst Wiek H., Viikari Jorma S., Visscher Peter M., Vitart Veronique, Völker Uwe, Waldenberger Melanie, Weichenberger Christian X., Westra Harm-Jan, Wijmenga Cisca, Wolffenbuttel Bruce H., Yang Jian, Bezzina Connie R., Munroe Patricia B., Snieder Harold, Wright Alan F., Rudan Igor, Boyer Laurie A., Asselbergs Folkert W., van Veldhuisen Dirk J., Stricker Bruno H., Psaty Bruce M., Ciullo Marina, Sanna Serena, Lehtimäki Terho, Wilson James F., Bandinelli Stefania, Alonso Alvaro, Gasparini Paolo, Jukema J. Wouter, Kääb Stefan, Gudnason Vilmundur, Felix Stephan B., Heckbert Susan R., de Boer Rudolf A., Newton-Cheh Christopher, Hicks Andrew A., Chambers John C., Jamshidi Yalda, Visel Axel, Christoffels Vincent M., Isaacs Aaron, Samani Nilesh J., de Bakker Paul I. W. 52 Genetic Loci Influencing Myocardial Mass Journal of the American College of Cardiology 2016;68 (13):1435-1448 [PubMed]
  • Burger Nicole B., Matias Alexandra, Kok Evelien, de Groot Christianne J. M., Christoffels Vincent M., Bekker Mireille N., Haak Monique C. Absence of an anatomical origin for altered ductus venosus flow velocity waveforms in first-trimester human fetuses with increased nuchal translucency Prenatal diagnosis 2016;36 (6):537-544 [PubMed]
  • de Bakker Bernadette S., de Jong Kees H., Hagoort Jaco, de Bree Karel, Besselink Clara T., de Kanter Froukje E. C., Veldhuis Tyas, Bais Babette, Schildmeijer Reggie, Ruijter Jan M., Oostra Roelof-Jan, Christoffels Vincent M., Moorman Antoon F. M. An interactive three-dimensional digital atlas and quantitative database of human development Science 2016;354 (6315):1019 aag0053-+ [PubMed]
  • Burger Nicole B., Haak Monique C., Kok Evelien, de Groot Christianne J. M., Shou Weinian, Scambler Peter J., Lee Youngsook, Cho Eunjin, Christoffels Vincent M., Bekker Mireille N. Cardiac defects, nuchal edema and abnormal lymphatic development are not associated with morphological changes in the ductus venosus Early human development 2016;101:39-48 [PubMed]
  • Burger Nicole B. Developmental origins of increased nuchal translucency 2016. 193p. ISBN 9789462993846. [UvA Dissertations Online] Vrije Universiteit Amsterdam: faculteit Geneeskunde. (Supervisors: de Groot C. J. M., Christoffels V. M.; Co-supervisors: Bekker M. N., Haak M. C.)
  • Boukens Bastiaan J., Coronel Ruben, Christoffels Vincent M. Embryonic development of the right ventricular outflow tract and arrhythmias Heart rhythm 2016;13 (2):616-622 [PubMed]
  • van Duijvenboden Karel, de Boer Bouke A., Capon Nicolas, Ruijter Jan M., Christoffels Vincent M. EMERGE: a flexible modelling framework to predict genomic regulatory elements from genomic signatures Nucleic acids research 2016;44 (5):e42 [PubMed]
  • Postma Alex V., Bezzina Connie R., Christoffels Vincent M. Genetics of congenital heart disease: the contribution of the noncoding regulatory genome Journal of human genetics 2016;61 (1):13-19 [PubMed]
  • Sergeeva Irina A., Hooijkaas Ingeborg B., Ruijter Jan M., van der Made Ingeborg, de Groot Nina E., van de Werken Harmen J. G., Creemers Esther E., Christoffels Vincent M. Identification of a regulatory domain controlling the Nppa-Nppb gene cluster during heart development and stress Development (Cambridge, England) 2016;143 (12):2135-2146 [PubMed]
  • Greulich Franziska, Rudat Carsten, Farin Henner F., Christoffels Vincent M., Kispert Andreas Lack of Genetic Interaction between Tbx18 and Tbx2/Tbx20 in Mouse Epicardial Development PLoS ONE 2016;11 (6):e0156787 [PubMed]
  • Nadadur Rangarajan D., Broman Michael T., Boukens Bastiaan, Mazurek Stefan R., Yang Xinan, van den Boogaard Malou, Bekeny Jenna, Gadek Margaret, Ward Tarsha, Zhang Min, Qiao Yun, Martin James F., Seidman Christine E., Seidman Jon, Christoffels Vincent, Efimov Igor R., McNally Elizabeth M., Weber Christopher R., Moskowitz Ivan P. Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm Science translational medicine 2016;8 (354):354ra115 [PubMed]
  • van Weerd Jan Hendrik, Christoffels Vincent M. Regulation of Vertebrate Conduction System Developmentin: Toshio Nakanishi, Roger R. Markwald, H. Scott Baldwin, Bradley B. Keller, Deepak Srivastava, Hiroyuki Yamagishi, editors. Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology. S.l.: Springer Open; 2016. p. 269-280, ISBN 9784431546276
  • Lüdtke Timo H., Rudat Carsten, Wojahn Irina, Weiss Anna-Carina, Kleppa Marc-Jens, Kurz Jennifer, Farin Henner F., Moon Anne, Christoffels Vincent M., Kispert Andreas Tbx2 and Tbx3 Act Downstream of Shh to Maintain Canonical Wnt Signaling during Branching Morphogenesis of the Murine Lung Developmental cell 2016;39 (2):239-253 [PubMed]
  • van Weerd Jan Hendrik, Christoffels Vincent M. The formation and function of the cardiac conduction system Development (Cambridge, England) 2016;143 (2):197-210 [PubMed]

2015

  • Gillers Benjamin S., Chiplunkar Aditi, Aly Haytham, Valenta Tomas, Basler Konrad, Christoffels Vincent M., Efimov Igor R., Boukens Bastiaan J., Rentschler Stacey Canonical wnt signaling regulates atrioventricular junction programming and electrophysiological properties Circulation research 2015;116 (3):398-406 [PubMed]
  • Sergeeva Irina Alexandrovna Functional organization of the natriuretic peptide gene cluster in development and disease 2015. 141p. ISBN 9789461825940. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Christoffels V. M.)
  • Stefanovic Sonia, Christoffels Vincent M. GATA-dependent transcriptional and epigenetic control of cardiac lineage specification and differentiation Cellular and molecular life sciences 2015;72 (20):3871-3881 [PubMed]
  • Burger Nicole B., Bekker Mireille N., Kok Evelien, de Groot Christianne J. M., Martin James F., Shou Weinian, Scambler Peter J., Lee Youngsook, Christoffels Vincent M., Haak Monique C. Increased nuchal translucency origins from abnormal lymphatic development and is independent of the presence of a cardiac defect Prenatal diagnosis 2015;35 (13):1278-1286 [PubMed]
  • Boink Gerard J. J., Christoffels Vincent M., Robinson Richard B., Tan Hanno L. The past, present, and future of pacemaker therapies Trends in cardiovascular medicine 2015;25 (8):661-673 [PubMed]
  • Burger Nicole B., Bekker Mireille N., de Groot Christianne J. M., Christoffels Vincent M., Haak Monique C. Why increased nuchal translucency is associated with congenital heart disease: a systematic review on genetic mechanisms Prenatal diagnosis 2015;35 (6):517-528 [PubMed]

2014

  • van den Boogaard Malou, Smemo Scott, Burnicka-Turek Ozanna, Arnolds David E., van de Werken Harmen J. G., Klous Petra, McKean David, Muehlschlegel Jochen D., Moosmann Julia, Toka Okan, Yang Xinan H., Koopmann Tamara T., Adriaens Michiel E., Bezzina Connie R., de Laat Wouter, Seidman Christine, Seidman J. G., Christoffels Vincent M., Nobrega Marcelo A., Barnett Phil, Moskowitz Ivan P. A common genetic variant within SCN10A modulates cardiac SCN5A expression Journal of clinical investigation 2014;124 (4):1844-1852 [PubMed]
  • van Weerd Jan Hendrik, Badi Ileana, van den Boogaard Malou, Stefanovic Sonia, van de Werken Harmen J. G., Gomez-Velazquez Melisa, Badia-Careaga Claudio, Manzanares Miguel, de Laat Wouter, Barnett Phil, Christoffels Vincent M. A large permissive regulatory domain exclusively controls Tbx3 expression in the cardiac conduction system Circulation research 2014;115 (4):432-441 [PubMed]
  • Mohan Rajiv A., van Engelen Klaartje, Stefanovic Sonia, Barnett Phil, Ilgun Aho, Baars Marieke J. H., Bouma Berto J., Mulder Barbara J. M., Christoffels Vincent M., Postma Alex V. A mutation in the Kozak sequence of GATA4 hampers translation in a family with atrial septal defects American journal of medical genetics. Part A 2014;164AA (11):2732-2738 [PubMed]
  • Sergeeva Irina A., Hooijkaas Ingeborg B., van der Made Ingeborg, Jong Willeke M. C., Creemers Esther E., Christoffels Vincent M. A transgenic mouse model for the simultaneous monitoring of ANF and BNP gene activity during heart development and disease Cardiovascular research 2014;101 (1):78-86 [PubMed]
  • Burggren W. W., Christoffels V. M., Crossley D. A., Enok S., Farrell A. P., Hedrick M. S., Hicks J. W., Jensen B., Moorman A. F. M., Mueller C. A., Skovgaard N., Taylor E. W., Wang T. Comparative cardiovascular physiology: future trends, opportunities and challenges Acta physiologica (Oxford, England) 2014;210 (2):257-276 [PubMed]
  • Rana M. Sameer, Sizarov Aleksander, Christoffels Vincent M., Moorman Antoon F. M. Development of the human aortic arch system captured in an interactive three-dimensional reference model American journal of medical genetics. Part A 2014;164A (6):1372-1383 [PubMed]
  • Jensen Bjarke, Boukens Bastiaan J. D., Wang Tobias, Moorman Antoon F. M., Christoffels Vincent M. Evolution of the Sinus Venosus from Fish to Human Journal of cardiovascular development and disease 2014;1:14-28
  • van den Boogaard Malou, Barnett Phil, Christoffels Vincent M. From GWAS to function: genetic variation in sodium channel gene enhancer influences electrical patterning Trends in cardiovascular medicine 2014;24 (3):99-104 [PubMed]
  • Stefanovic Sonia, Barnett Phil, van Duijvenboden Karel, Weber David, Gessler Manfred, Christoffels Vincent M. GATA-dependent regulatory switches establish atrioventricular canal specificity during heart development Nature communications 2014;5:3680 [PubMed]
  • van Duijvenboden Karel, Ruijter Jan M., Christoffels Vincent M. Gene regulatory elements of the cardiac conduction system Briefings in functional genomics 2014;13 (1):28-38 [PubMed]
  • Verweij Niek, Mateo Leach Irene, van den Boogaard Malou, van Veldhuisen Dirk J., Christoffels Vincent M., Hillege Hans L., van Gilst Wiek H., Barnett Phil, de Boer Rudolf A., van der Harst Pim Genetic determinants of P wave duration and PR segment Circulation. Cardiovascular genetics 2014;7 (4):475-481 [PubMed]
  • Osterwalder Marco, Speziale Dario, Shoukry Malak, Mohan Rajiv, Ivanek Robert, Kohler Manuel, Beisel Christian, Wen Xiaohui, Scales Suzie J., Christoffels Vincent M., Visel Axel, Lopez-Rios Javier, Zeller Rolf HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme Developmental cell 2014;31 (3):345-357 [PubMed]
  • Franco Diego, Christoffels Vincent M., Campione Marina Homeobox transcription factor Pitx2: The rise of an asymmetry gene in cardiogenesis and arrhythmogenesis Trends in cardiovascular medicine 2014;24 (1):23-31 [PubMed]
  • de Boer Bouke A., Le Garrec Jean-François, Christoffels Vincent M., Meilhac Sigolène M., Ruijter Jan M. Integrating multi-scale knowledge on cardiac development into a computational model of ventricular trabeculation Wiley interdisciplinary reviews. Systems biology and medicine 2014;6 (6):389-397 [PubMed]
  • Burger Nicole B., Stuurman Kyra E., Kok Evelien, Konijn Tanja, Schooneman Dennis, Niederreither Karen, Coles Mark, Agace William W., Christoffels Vincent M., Mebius Reina E., van de Pavert Serge A., Bekker Mireille N. Involvement of neurons and retinoic acid in lymphatic development: new insights in increased nuchal translucency Prenatal diagnosis 2014;34 (13):1312-1319 [PubMed]
  • Davies Laura, Jin Jiawei, Shen Weijin, Tsui Hoyee, Shi Ying, Wang Yanwen, Zhang Yanmin, Hao Guoliang, Wu Jingjing, Chen Si, Fraser James A., Dong Nianguo, Christoffels Vincent, Ravens Ursula, Huang Christopher L.-H., Zhang Henggui, Cartwright Elizabeth J., Wang Xin, Lei Ming Mkk4 is a negative regulator of the transforming growth factor beta 1 signaling associated with atrial remodeling and arrhythmogenesis with age Journal of the American Heart Association 2014;3 (2):e000340 [PubMed]
  • Rana M. Sameer Molecular and genetic basis of congenital conotruncal heart defects 2014. 178p. ISBN 9789491014291. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Christoffels V. M., Moorman A. F. M.)
  • de Boer Bouke A., van Duijvenboden Karel, van den Boogaard Malou, Christoffels Vincent M., Barnett Phil, Ruijter Jan M. OccuPeak: ChIP-Seq peak calling based on internal background modelling PLoS ONE 2014;9 (6):e99844 [PubMed]
  • Rana M. Sameer, Théveniau-Ruissy Magali, de Bono Christopher, Mesbah Karim, Francou Alexandre, Rammah Mayyasa, Domínguez Jorge N., Roux Marine, Laforest Brigitte, Anderson Robert H., Mohun Timothy, Zaffran Stephane, Christoffels Vincent M., Kelly Robert G. Tbx1 coordinates addition of posterior second heart field progenitor cells to the arterial and venous poles of the heart Circulation research 2014;115 (9):790-799 [PubMed]
  • Kunasegaran Kamini, Ho Victor, Chang Ted H.-T., de Silva Duvini, Bakker Martijn L., Christoffels Vincent M., Pietersen Alexandra M. Transcriptional repressor Tbx3 is required for the hormone-sensing cell lineage in mammary epithelium PLoS ONE 2014;9 (10):e110191 [PubMed]

2013

  • van den Boogaard M., Wong L. Y. E., Christoffels V. M., Barnett P. Acquisition of high quality DNA for massive parallel sequencing by in vivo chromatin immunoprecipitation Methods in molecular biology (Clifton, N.J.) 2013;977:53-64 [PubMed]
  • Rana M. S., Christoffels V. M., Moorman A. F. M. A molecular and genetic outline of cardiac morphogenesis Acta physiologica (Oxford, England) 2013;207 (4):588-615 [PubMed]
  • Bezzina Connie R., Barc Julien, Mizusawa Yuka, Remme Carol Ann, Gourraud Jean-Baptiste, Simonet Floriane, Verkerk Arie O., Schwartz Peter J., Crotti Lia, Dagradi Federica, Guicheney Pascale, Fressart Véronique, Leenhardt Antoine, Antzelevitch Charles, Bartkowiak Susan, Borggrefe Martin, Schimpf Rainer, Schulze-Bahr Eric, Zumhagen Sven, Behr Elijah R., Bastiaenen Rachel, Tfelt-Hansen Jacob, Olesen Morten Salling, Kääb Stefan, Beckmann Britt M., Weeke Peter, Watanabe Hiroshi, Endo Naoto, Minamino Tohru, Horie Minoru, Ohno Seiko, Hasegawa Kanae, Makita Naomasa, Nogami Akihiko, Shimizu Wataru, Aiba Takeshi, Froguel Philippe, Balkau Beverley, Lantieri Olivier, Torchio Margherita, Wiese Cornelia, Weber David, Wolswinkel Rianne, Coronel Ruben, Boukens Bas J., Bézieau Stéphane, Charpentier Eric, Chatel Stéphanie, Despres Aurore, Gros Françoise, Kyndt Florence, Lecointe Simon, Lindenbaum Pierre, Portero Vincent, Violleau Jade, Gessler Manfred, Tan Hanno L., Roden Dan M., Christoffels Vincent M., Le Marec Hervé, Wilde Arthur A., Probst Vincent, Schott Jean-Jacques, Dina Christian, Redon Richard Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death Nature genetics 2013;45 (9):1044-1049 [PubMed]
  • Bezzina Connie R., Barc Julien, Mizusawa Yuka, Remme Carol Ann, Gourraud Jean-Baptiste, Simonet Floriane, Verkerk Arie O., Schwartz Peter J., Crotti Lia, Dagradi Federica, Guicheney Pascale, Fressart Véronique, Leenhardt Antoine, Antzelevitch Charles, Bartkowiak Susan, Schulze-Bahr Eric, Zumhagen Sven, Behr Elijah R., Bastiaenen Rachel, Tfelt-Hansen Jacob, Olesen Morten Salling, Kääb Stefan, Beckmann Britt M., Weeke Peter, Watanabe Hiroshi, Endo Naoto, Minamino Tohru, Horie Minoru, Ohno Seiko, Hasegawa Kanae, Makita Naomasa, Nogami Akihiko, Shimizu Wataru, Aiba Takeshi, Froguel Philippe, Balkau Beverley, Lantieri Olivier, Torchio Margherita, Wiese Cornelia, Weber David, Wolswinkel Rianne, Coronel Ruben, Boukens Bas J., Bézieau Stéphane, Charpentier Eric, Chatel Stéphanie, Despres Aurore, Gros Françoise, Kyndt Florence, Lecointe Simon, Lindenbaum Pierre, Portero Vincent, Violleau Jade, Gessler Manfred, Tan Hanno L., Roden Dan M., Christoffels Vincent M., Le Marec Hervé, Wilde Arthur A., Probst Vincent, Schott Jean-Jacques, Dina Christian, Redon Richard Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death Nature genetics 2013;45 (11):1409 [PubMed]
  • Christoffels Vincent M., Pu William T. Developing insights into cardiac regeneration Development (Cambridge, England) 2013;140 (19):3933-3937 [PubMed]
  • Postma Alex V., Christoffels Vincent M., Moorman Antoon F.M. Developmental aspects of the electrophysiology of the heart: Function follows formin: Electrical Diseases of the Heart. Springer-Verlag London Ltd; 2013. p. 25-45, ISBN 9781447148807
  • Boukens Bas J., Hoogendijk Mark G., Verkerk Arie O., Linnenbank Andre, van Dam Peter, Remme Carol-Ann, Fiolet Jan W., Opthof Tobias, Christoffels Vincent M., Coronel Ruben Early repolarization in mice causes overestimation of ventricular activation time by the QRS duration Cardiovascular research 2013;97 (1):182-191 [PubMed]
  • Jensen Bjarke, Wang Tobias, Christoffels Vincent M., Moorman Antoon F. M. Evolution and development of the building plan of the vertebrate heart BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 2013;1833 (4):783-794 [PubMed]
  • Spruijt Nicole E., Rana M. Sameer, Christoffels Vincent M., Mink van der Molen Aebele B. Exploring a neurogenic basis of velopharyngeal dysfunction in Tbx1 mutant mice: no difference in volumes of the nucleus ambiguus International journal of pediatric otorhinolaryngology 2013;77 (6):1002-1007 [PubMed]
  • Wong L. Y. Elaine Genomic mapping of Tbx3 interactions in the heart 2013. 187p. ISBN 9789461822376. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Moorman A. F. M., Christoffels V. M.; Co-supervisor: Barnett P.)
  • Trowe Mark-Oliver, Zhao Li, Weiss Anna-Carina, Christoffels Vincent, Epstein Douglas J., Kispert Andreas Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis Development (Cambridge, England) 2013;140 (11):2299-2309 [PubMed]
  • Boogerd C. J. J., Christoffels V. M., Barnett P. Nuclear recruitment assay as a tool to validate transcription factor interactions in Mammalian cells Methods in molecular biology (Clifton, N.J.) 2013;977:243-248 [PubMed]
  • Boukens Bas J., Sylva Marc, de Gier-de Vries Corrie, Remme Carol Ann, Bezzina Connie R., Christoffels Vincent M., Coronel Ruben Reduced sodium channel function unmasks residual embryonic slow conduction in the adult right ventricular outflow tract Circulation research 2013;113 (2):137-141 [PubMed]
  • Sergeeva Irina A., Christoffels Vincent M. Regulation of expression of atrial and brain natriuretic peptide, biomarkers for heart development and disease BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2013;1832 (12):2403-2413 [PubMed]
  • Francou Alexandre, Saint-Michel Edouard, Mesbah Karim, Théveniau-Ruissy Magali, Rana M. Sameer, Christoffels Vincent M., Kelly Robert G. Second heart field cardiac progenitor cells in the early mouse embryo BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 2013;1833 (4):795-798 [PubMed]
  • Mommersteeg Mathilda T. M., Andrews William D., Ypsilanti Athena R., Zelina Pavol, Yeh Mason L., Norden Julia, Kispert Andreas, Chédotal Alain, Christoffels Vincent M., Parnavelas John G. Slit-roundabout signaling regulates the development of the cardiac systemic venous return and pericardium Circulation research 2013;112 (3):465-475 [PubMed]
  • Burger Nicole B., Haak Monique C., de Bakker Bernadette S., Al Shaibani Zaid, de Groot Christianne J. M., Christoffels Vincent M., Bekker Mireille N. Systematic analysis of the development of the ductus venosus in wild type mouse and human embryos Early human development 2013;89 (12):1067-1073 [PubMed]
  • Lüdtke Timo H.-W., Farin Henner F., Rudat Carsten, Schuster-Gossler Karin, Petry Marianne, Barnett Phil, Christoffels Vincent M., Kispert Andreas Tbx2 controls lung growth by direct repression of the cell cycle inhibitor genes Cdkn1a and Cdkn1b PLoS genetics 2013;9 (1):e1003189 [PubMed]
  • Farin Henner F., Lüdtke Timo H.-W., Schmidt Martina K., Placzko Susann, Schuster-Gossler Karin, Petry Marianne, Christoffels Vincent M., Kispert Andreas Tbx2 terminates shh/fgf signaling in the developing mouse limb bud by direct repression of gremlin1 PLoS genetics 2013;9 (4):e1003467 [PubMed]
  • de Laat Monique W. M., Pieper Petronella G., Oudijk Martijn A., Mulder Barbara J. M., Christoffels Vincent M., Afink Gijs B., Postma Alex V., Ris-Stalpers Carrie The clinical and molecular relations between idiopathic preterm labor and maternal congenital heart defects Reproductive sciences (Thousand Oaks, Calif.) 2013;20 (2):190-201 [PubMed]

2012

  • Boukens Bas J. D. Electrophysiological patterning of the heart 2012. 167p. ISBN 9789461909978. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Christoffels V. M.; Co-supervisor: Coronel R.)
  • Boukens Bastiaan J., Christoffels Vincent M. Electrophysiological Patterning of the Heart Pediatric cardiology 2012;33 (6):900-906 [PubMed]
  • van den Boogaard Malou, Wong L. Y. Elaine, Tessadori Federico, Bakker Martijn L., Dreizehnter Lisa K., Wakker Vincent, Bezzina Connie R., 't Hoen Peter A. C., Bakkers Jeroen, Barnett Phil, Christoffels Vincent M. Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer Journal of clinical investigation 2012;122 (7):2519-2530 [PubMed]
  • Tessadori Federico, van Weerd Jan Hendrik, Burkhard Silja B., Verkerk Arie O., de Pater Emma, Boukens Bastiaan J., Vink Aryan, Christoffels Vincent M., Bakkers Jeroen Identification and Functional Characterization of Cardiac Pacemaker Cells in Zebrafish PLoS ONE 2012;7 (10):e47644 [PubMed]
  • Mesbah Karim, Rana M. Sameer, Francou Alexandre, van Duijvenboden Karel, Papaioannou Virginia E., Moorman Antoon F., Kelly Robert G., Christoffels Vincent M. Identification of a Tbx1/Tbx2/Tbx3 genetic pathway governing pharyngeal and arterial pole morphogenesis Human molecular genetics 2012;21 (6):1217-1229 [PubMed]
  • Jensen Bjarke, Boukens Bastiaan J. D., Postma Alex V., Gunst Quinn D., van den Hoff Maurice J. B., Moorman Antoon F. M., Wang Tobias, Christoffels Vincent M. Identifying the Evolutionary Building Blocks of the Cardiac Conduction System PLoS ONE 2012;7 (9):e44231 [PubMed]
  • Frank Deborah U., Carter Kandis L., Thomas Kirk R., Burr R. Michael, Bakker Martijn L., Coetzee William A., Tristani-Firouzi Martin, Bamshad Michael J., Christoffels Vincent M., Moon Anne M. Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis Proceedings of the National Academy of Sciences of the United States of America 2012;109 (3):E154-E163 [PubMed]
  • Barnett Phil, van den Boogaard Malou, Christoffels Vincent LOCALIZED AND TEMPORAL GENE REGULATION IN HEART DEVELOPMENT Current topics in developmental biology 2012;100:171-201 [PubMed]
  • Norden Julia, Grieskamp Thomas, Christoffels Vincent M., Moorman Antoon F. M., Kispert Andreas Partial Absence of Pleuropericardial Membranes in Tbx18- and Wt1-Deficient Mice PLoS ONE 2012;7 (9):e45100 [PubMed]
  • Boukens Bastiaan J., Christoffels Vincent M. Popeye proteins: muscle for the aging sinus node Journal of clinical investigation 2012;122 (3):810-813 [PubMed]
  • Bakker Martijn L. Role of Tbx3 in conduction system development 2012. 192p. ISBN 9789461909879. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Christoffels V. M., Moorman A. F. M.)
  • Bakker Martijn L., Boink Gerard J. J., Boukens Bas J., Verkerk Arie O., van den Boogaard Malou, Den Haan A. Denise, Hoogaars Willem M. H., Buermans Henk P., de Bakker Jacques M. T., Seppen Jurgen, Tan Hanno L., Moorman Antoon F. M., 't Hoen Peter A. C., Christoffels Vincent M. T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells Cardiovascular research 2012;94 (3):439-449 [PubMed]
  • Singh Reena, Hoogaars Willem M., Barnett Phil, Grieskamp Thomas, Rana M. Sameer, Buermans Henk, Farin Henner F., Petry Marianne, Heallen Todd, Martin James F., Moorman Antoon F. M., 't Hoen Peter A. C., Kispert Andreas, Christoffels Vincent M. Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation Cellular and molecular life sciences 2012;69 (8):1377-1389 [PubMed]
  • van Engelen Klaartje, Mommersteeg Mathilda T. M., Baars Marieke J. H., Lam Jan, Ilgun Aho, van Trotsenburg A. S. Paul, Smets Anne M. J. B., Christoffels Vincent M., Mulder Barbara J. M., Postma Alex V. The Ambiguous Role of NKX2-5 Mutations in Thyroid Dysgenesis PLoS ONE 2012;7 (12):e52685 [PubMed]
  • Hyde Annastasia S., Farmer Erin L., Easley Katherine E., van Lammeren Kristy, Christoffels Vincent M., Barycki Joseph J., Bakkers Jeroen, Simpson Melanie A. UDP-glucose Dehydrogenase Polymorphisms from Patients with Congenital Heart Valve Defects Disrupt Enzyme Stability and Quaternary Assembly Journal of biological chemistry 2012;287 (39):32708-32716 [PubMed]

2011

  • Aanhaanen Wim T. J., Boukens Bastiaan J. D., Sizarov Aleksander, Wakker Vincent, de Gier-de Vries Corrie, van Ginneken Antoni C., Moorman Antoon F. M., Coronel Ruben, Christoffels Vincent M. Defective Tbx2-dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice Journal of clinical investigation 2011;121 (2):534-544 [PubMed]
  • Postma Alex V., Christoffels Vincent M., Bezzina Connie R. Developmental aspects of cardiac arrhythmogenesis Cardiovascular research 2011;91 (2):243-251 [PubMed]
  • Sizarov Aleksander, Ya Jing, de Boer Bouke A., Lamers Wouter H., Christoffels Vincent M., Moorman Antoon F. M. Formation of the Building Plan of the Human Heart Morphogenesis, Growth, and Differentiation Circulation 2011;123 (10):1125-U285 [PubMed]
  • Sizarov Aleksander, Devalla Harsha D., Anderson Robert H., Passier Robert, Christoffels Vincent M., Moorman Antoon F. M. Molecular analysis of patterning of conduction tissues in the developing human heart Circulation. Arrhythmia and electrophysiology 2011;4 (4):532-542 [PubMed]
  • Cai Xiaoqiang, Nomura-Kitabayashi Aya, Cai Weibin, Yan Jianyun, Christoffels Vincent M., Cai Chen-Leng Myocardial Tbx20 regulates early atrioventricular canal formation and endocardial epithelial-mesenchymal transition via Bmp2 Developmental biology 2011;360 (2):381-390 [PubMed]
  • Aanhaanen Wim T. J., Moorman Antoon F. M., Christoffels Vincent M. Origin and development of the atrioventricular myocardial lineage: insight into the development of accessory pathways Birth defects research. Part A, Clinical and molecular teratology 2011;91 (6):565-577 [PubMed]
  • Christoffels Vincent REGENERATIVE MEDICINE Muscle for a damaged heart Nature 2011;474 (7353):585-586 [PubMed]
  • Boogerd C. J. J., Wong L. Y. E., van den Boogaard M., Bakker M. L., Tessadori F., Bakkers J., 't Hoen P. A. C., Moorman A. F., Christoffels V. M., Barnett P. Sox4 mediates Tbx3 transcriptional regulation of the gap junction protein Cx43 Cellular and molecular life sciences 2011;68 (23):3949-3961 [PubMed]
  • Aanhaanen Wim T. J. The role of Tbx2 in the development of the atrioventriculair canal and conduction system to the heart. 'Making the beat go on and on' 2011. 151p. ISBN 9789461910837. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Moorman A. F. M., Christoffels V. M.)
  • Verhoeven Manon C., Haase Christa, Christoffels Vincent M., Weidinger Gilbert, Bakkers Jeroen Wnt signaling regulates atrioventricular canal formation upstream of BMP and Tbx2 Birth defects research. Part A, Clinical and molecular teratology 2011;91 (6):435-440 [PubMed]

2010

  • Aanhaanen Wim T. J., Mommersteeg Mathilda T. M., Norden Julia, Wakker Vincent, de Gier-de Vries Corrie, Anderson Robert H., Kispert Andreas, Moorman Antoon F. M., Christoffels Vincent M. Developmental Origin, Growth, and Three-Dimensional Architecture of the Atrioventricular Conduction Axis of the Mouse Heart Circulation research 2010;107 (6):728-U98 [PubMed]
  • Christoffels Vincent M., Smits Gertien J., Kispert Andreas, Moorman Antoon F. M. Development of the Pacemaker Tissues of the Heart Circulation research 2010;106 (2):240-254 [PubMed]
  • Lage Kasper, Møllgård Kjeld, Greenway Steven, Wakimoto Hiroko, Gorham Joshua M., Workman Christopher T., Bendsen Eske, Hansen Niclas T., Rigina Olga, Roque Francisco S., Wiese Cornelia, Christoffels Vincent M., Roberts Amy E., Smoot Leslie B., Pu William T., Donahoe Patricia K., Tommerup Niels, Brunak Søren, Seidman Christine E., Seidman Jonathan G., Larsen Lars A. Dissecting spatio-temporal protein networks driving human heart development and related disorders Molecular systems biology 2010;6:381 [PubMed]
  • Wakker Vincent, Brons Janynke F., Aanhaanen Wim T. J., van Roon Marian A., Moorman Antoon F. M., Christoffels Vincent M. Generation of Mice With a Conditional Null Allele For Tbx2 Genesis (New York, N.Y. 2010;48 (3):195-199 [PubMed]
  • Bakker Martijn L., Moorman Antoon F. M., Christoffels Vincent M. The atrioventricular node: origin, development, and genetic program Trends in cardiovascular medicine 2010;20 (5):164-171 [PubMed]
  • Bakker Martijn L., Christoffels Vincent M., Moorman Antoon F. M. The Cardiac Pacemaker and Conduction System Develops From Embryonic Myocardium that Retains Its Primitive Phenotype Journal of cardiovascular pharmacology 2010;56 (1):6-15 [PubMed]
  • Mommersteeg Mathilda T. M., Domínguez Jorge N., Wiese Cornelia, Norden Julia, de Gier-de Vries Corrie, Burch John B. E., Kispert Andreas, Brown Nigel A., Moorman Antoon F. M., Christoffels Vincent M. The sinus venosus progenitors separate and diversify from the first and second heart fields early in development Cardiovascular research 2010;87 (1):92-101 [PubMed]
  • Sizarov Aleksander, Anderson Robert H., Christoffels Vincent M., Moorman Antoon F. M. Three-Dimensional and Molecular Analysis of the Venous Pole of the Developing Human Heart Circulation 2010;122 (8):798-U104 [PubMed]
  • Norden Julia, Grieskamp Thomas, Lausch Ekkehart, van Wijk Bram, van den Hoff Maurice J. B., Englert Christoph, Petry Marianne, Mommersteeg Mathilda T. M., Christoffels Vincent M., Niederreither Karen, Kispert Andreas Wt1 and Retinoic Acid Signaling in the Subcoelomic Mesenchyme Control the Development of the Pleuropericardial Membranes and the Sinus Horns Circulation research 2010;106 (7):1212-U97 [PubMed]

2009

  • Mommersteeg Mathilda T. M., Christoffels Vincent M., Anderson Robert H., Moorman Antoon F. M. Atrial fibrillation: A developmental point of view Heart rhythm 2009;6 (12):1818-1824 [PubMed]
  • Horsthuis Thomas, Christoffels Vincent M., Anderson Robert H., Moorman Antoon F. M. Can recent insights into cardiac development improve our understanding of congenitally malformed hearts? Clinical anatomy (New York, N.Y.) 2009;22 (1):4-20 [PubMed]
  • Boukens Bastiaan J. D., Christoffels Vincent M., Coronel Ruben, Moorman Antoon F. M. Developmental basis for electrophysiological heterogeneity in the ventricular and outflow tract myocardium as a substrate for life-threatening ventricular arrhythmias Circulation research 2009;104 (1):19-31 [PubMed]
  • Christoffels Vincent M., Moorman Antoon F. M. Development of the cardiac conduction system: why are some regions of the heart more arrhythmogenic than others? Circulation. Arrhythmia and electrophysiology 2009;2 (2):195-207 [PubMed]
  • Zirzow Susann, Lüdtke Timo H.-W., Brons Janynke F., Petry Marianne, Christoffels Vincent M., Kispert Andreas Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse Developmental biology 2009;336 (2):145-155 [PubMed]
  • Wiese Cornelia, Grieskamp Thomas, Airik Rannar, Mommersteeg Mathilda T. M., Gardiwal Ajmal, de Gier-de Vries Corrie, Schuster-Gossler Karin, Moorman Antoon F. M., Kispert Andreas, Christoffels Vincent M. Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by Tbx18 and Tbx3 Circulation research 2009;104 (3):388-397 [PubMed]
  • Horsthuis Thomas, Buermans Henk P. J., Brons Janynke F., Verkerk Arie O., Bakker Martijn L., Wakker Vincent, Clout Danielle E. W., Moorman Antoon F. M., 't Hoen Peter A. C., Christoffels Vincent M. Gene expression profiling of the forming atrioventricular node using a novel tbx3-based node-specific transgenic reporter Circulation research 2009;105 (1):61-69 [PubMed]
  • Horsthuis Thomas Regulation of the diversification of the nodal and chamber myocardium 2009. 143p. ISBN 9789490122300. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Moorman A. F. M.; Co-supervisor: Christoffels V. M.)
  • Christoffels Vincent M., Grieskamp Thomas, Norden Julia, Mommersteeg Mathilda T. M., Rudat Carsten, Kispert Andreas Tbx18 and the fate of epicardial progenitors Nature 2009;458 (7240):E8-E9 [PubMed]
  • Singh Reena, Horsthuis Thomas, Farin Henner F., Grieskamp Thomas, Norden Julia, Petry Marianne, Wakker Vincent, Moorman Antoon F. M., Christoffels Vincent M., Kispert Andreas Tbx20 interacts with smads to confine tbx2 expression to the atrioventricular canal Circulation research 2009;105 (5):442-452 [PubMed]
  • Lüdtke Timo H.-W., Christoffels Vincent M., Petry Marianne, Kispert Andreas Tbx3 Promotes Liver Bud Expansion During Mouse Development by Suppression of Cholangiocyte Differentiation Hepatology (Baltimore, Md.) 2009;49 (3):969-978 [PubMed]
  • Remme C. A., Verkerk A. O., Hoogaars W. M. H., Aanhaanen W. T. J., Scicluna B. P., Annink C., van den Hoff M. J. B., Wilde A. A. M., van Veen T. A. B., Veldkamp M. W., de Bakker J. M. T., Christoffels V. M., Bezzina C. R. The cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium Basic research in cardiology 2009;104 (5):511-522 [PubMed]
  • Mommersteeg Mathilda T. M. The development of the venous pole of the heart 2009. 160p. ISBN 9789081451116. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Moorman A. F. M.; Co-supervisor: Christoffels V. M.)
  • Aanhaanen Wim T. J., Brons Janynke F., Domínguez Jorge N., Rana M. Sameer, Norden Julia, Airik Rannar, Wakker Vincent, de Gier-de Vries Corrie, Brown Nigel A., Kispert Andreas, Moorman Antoon F. M., Christoffels Vincent M. The Tbx2+ primary myocardium of the atrioventricular canal forms the atrioventricular node and the base of the left ventricle Circulation research 2009;104 (11):1267-1274 [PubMed]

2008

  • Postma Alex V., van de Meerakker Judith B. A., Mathijssen Inge B., Barnett Phil, Christoffels Vincent M., Ilgun Aho, Lam Jan, Wilde Arthur A. M., Lekanne Deprez Ronald H., Moorman Antoon F. M. A gain-of-function TBX5 mutation is associated with atypical Holt-Oram syndrome and paroxysmal atrial fibrillation Circulation research 2008;102 (11):1433-1442 [PubMed]
  • Postma A. V., Christoffels V. M., Moorman A. F. M. Developmental aspects of the electrophysiology of the heart: function follows formin: Ihor Gussak, Charles Antzelevitch, Arthur A. M. Wilde, Paul A. Friedman, Michael J. Ackerman, Win-Kuang Shen, editors. Electrical diseases of the heart. Genetics, mechanisms, treatment, prevention.. London: Springer; 2008. p. 24-36, ISBN 9781846288531
  • Horsthuis Thomas, Houweling Arjan C., Habets Petra E. M. H., de Lange Frederik J., El Azzouzi Hamid, Clout Danielle E. W., Moorman Antoon F. M., Christoffels Vincent M. Distinct regulation of developmental and heart disease-induced atrial natriuretic factor expression by two separate distal sequences Circulation research 2008;102 (7):849-859 [PubMed]
  • Anderson R. H., Boyett M. R., Dobrzynski H., Yanni J., Christoffels V. M., Moorman A. F. M. Letter by anderson et al regarding article, "abnormal conduction and morphology in the atrioventricular node of mice with atrioventricular canal-targeted deletion of Alk3/Bmpr1a receptor" Circulation 2008;118 (6):e105; author reply e107 [PubMed]
  • Hoogaars W. M. H., Christoffels V. M., Moorman A. F. M. Morphogenesisiof the vertebrate heartin: R. Bodmer, editors. Cardiovascular development. Amsterdam: Academic Press, Elsevier; 2008. p. 31-68, ISBN 9780444530141
  • Boogerd Kees-Jan, Wong L. Y. Elaine, Christoffels Vincent M., Klarenbeek Meinke, Ruijter Jan M., Moorman Antoon F. M., Barnett Phil Msx1 and Msx2 are functional interacting partners of T-box factors in the regulation of Connexin43 Cardiovascular research 2008;78 (3):485-493 [PubMed]
  • Hoogaars Willem M. H., Barnett Phil, Rodriguez Mercedes, Clout Danielle E., Moorman Antoon F. M., Goding Colin R., Christoffels Vincent M. TBX3 and its splice variant TBX3 + exon 2a are functionally similar Pigment cell & melanoma research 2008;21 (3):379-387 [PubMed]
  • Bakker Martijn L., Boukens Bastiaan J., Mommersteeg Mathilda T. M., Brons Janynke F., Wakker Vincent, Moorman Antoon F. M., Christoffels Vincent M. Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system Circulation research 2008;102 (11):1340-1349 [PubMed]

2007

  • Stoykov I., van Beeren H. C., Moorman A. F. M., Christoffels V. M., Wiersinga W. M., Bakker O. Effect of amiodarone and dronedarone administration in rats on thyroid hormone-dependent gene expression in different cardiac components European journal of endocrinology / European Federation of Endocrine Societies 2007;156 (6):695-702 [PubMed]
  • de Lange Frederik J. Genetic lineage analysis of the developing heartUniversiteit van Amsterdam: 2007. 184p. ISBN 9789090191560. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Moorman Antoon F. M.; Co-supervisor: Christoffels Vincent M.)
  • Mommersteeg Mathilda T. M., Hoogaars Willem M. H., Prall Owen W. J., de Gier-de Vries Corrie, Wiese Cornelia, Clout Danielle E. W., Papaioannou Virginia E., Brown Nigel A., Harvey Richard P., Moorman Antoon F. M., Christoffels Vincent M. Molecular pathway for the localized formation of the sinoatrial node Circulation research 2007;100 (3):354-362 [PubMed]
  • Mommersteeg Mathilda T. M., Brown Nigel A., Prall Owen W. J., de Gier-de Vries Corrie, Harvey Richard P., Moorman Antoon F. M., Christoffels Vincent M. Pitx2c and Nkx2-5 are required for the formation and identity of the pulmonary myocardium Circulation research 2007;101 (9):902-909 [PubMed]
  • Hoogaars W. M. H., Barnett P., Moorman A. F. M., Christoffels V. M. T-box factors determine cardiac design Cellular and molecular life sciences 2007;64 (6):646-660 [PubMed]
  • Hoogaars Willem M. H., Engel Angela, Brons Janynke F., Verkerk Arie O., de Lange Frederik J., Wong L. Y. Elaine, Bakker Martijn L., Clout Danielle E., Wakker Vincent, Barnett Phil, Ravesloot Jan Hindrik, Moorman Antoon F. M., Verheijck E. Etienne, Christoffels Vincent M. Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria Genes & development 2007;21 (9):1098-1112 [PubMed]
  • Moorman Antoon F. M., Christoffels Vincent M., Anderson Robert H., van den Hoff Maurice J. B. The heart-forming fields: one or multiple? Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2007;362 (1484):1257-1265 [PubMed]
  • Hoogaars Willem M. H. The role of Tbx3 in the formation of the cardiac conduction systemUniversiteit van Amsterdam: 2007. 202p. ISBN 9789090223193. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Moorman A. F. M.; Co-supervisor: Christoffels V. M.)

2006

  • Stoykov I., Zandieh-Doulabi B., Moorman A. F. M., Christoffels V., Wiersinga W. M., Bakker O. Expression pattern and ontogenesis of thyroid hormone receptor isoforms in the mouse heart Journal of endocrinology 2006;189 (2):231-245 [PubMed]
  • Christoffels Vincent M., Mommersteeg Mathilda T. M., Trowe Mark-Oliver, Prall Owen W. J., de Gier-de Vries Corrie, Soufan Alexandre T., Bussen Markus, Schuster-Gossler Karin, Harvey Richard P., Moorman Antoon F. M., Kispert Andreas Formation of the venous pole of the heart from an Nkx2-5-negative precursor population requires Tbx18 Circulation research 2006;98 (12):1555-1563 [PubMed]
  • Franco Diego, Meilhac Sigolène M., Christoffels Vincent M., Kispert Andreas, Buckingham Margaret, Kelly Robert G. Left and right ventricular contributions to the formation of the interventricular septum in the mouse heart Developmental biology 2006;294 (2):366-375 [PubMed]
  • Houweling A. C. Regulation of regionalized gene expression in the developing heart 2006. 171p. ISBN 9789090205854. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Moorman A. F. M.; Co-supervisor: Christoffels V. M.)
  • Mommersteeg Mathilda T. M., Soufan Alexandre T., de Lange Frederik J., van den Hoff Maurice J. B., Anderson Robert H., Christoffels Vincent M., Moorman Antoon F. M. Two distinct pools of mesenchyme contribute to the development of the atrial septum Circulation research 2006;99 (4):351-353 [PubMed]

2005

  • Moorman Antoon F. M., Christoffels Vincent M., Anderson Robert H. Anatomic substrates for cardiac conduction Heart rhythm 2005;2 (8):875-886 [PubMed]
  • Houweling Arjan C., Somi Semir, Massink Maarten P. G., Groenen Martien A., Moorman Antoon F. M., Christoffels Vincent M. Comparative analysis of the natriuretic peptide precursor gene cluster in vertebrates reveals loss of ANF and retention of CNP-3 in chicken Developmental dynamics 2005;233 (3):1076-1082 [PubMed]
  • Moorman A. F. M., Christoffels V. M. Concepts of cardiac development. Why some parts of the heart are more arrhythmogenic than other partsin: N. M. van Hemel, F. E. E. Vermeulen, J. M. T. de Bakker, editors. Exclusion or Targetting?. Nieuwegein: Grafische Producties Budde-Elinkwijk; 2005. p. 103-112, ISBN 9789090191843
  • Moorman A. F. M., de Boer P. A. J., Small E. M., Krieg P. A., Christoffels V. M. Evolutionary conservation of atrial natriureyic factor (Anf) expression, cardiac chamber formation, and the heart-forming regionin: M. Artman, D. W. Benson, D. Srivastava, M. Nakazawa, editors. Cardiovascular development and congenital malformations: molecular & genetic mechanisms. Maldem, MA: Blackwell Futura; 2005. p. 84-87, ISBN 9781397840516
  • Houweling Arjan C., van Borren Marcel M., Moorman Antoon F. M., Christoffels Vincent M. Expression and regulation of the atrial natriuretic factor encoding gene Nppa during development and disease Cardiovascular research 2005;67 (4):583-593 [PubMed]
  • Fiore Roberto, Rahim Belquis, Christoffels Vincent M., Moorman Antoon F. M., Püschel Andreas W. Inactivation of the Sema5a gene results in embryonic lethality and defective remodeling of the cranial vascular system Molecular and cellular biology 2005;25 (6):2310-2319 [PubMed]
  • Singh Manvendra K., Christoffels Vincent M., Dias José M., Trowe Mark-Oliver, Petry Marianne, Schuster-Gossler Karin, Bürger Antje, Ericson Johan, Kispert Andreas Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2 Development (Cambridge, England) 2005;132 (12):2697-2707 [PubMed]

2004

  • Christoffels Vincent M., Burch John B. E., Moorman Antoon F. M. Architectural plan for the heart: early patterning and delineation of the chambers and the nodes Trends in cardiovascular medicine 2004;14 (8):301-307 [PubMed]
  • Anderson Robert H., Christoffels Vincent M., Moorman Antoon F. M. Controversies concerning the anatomical definition of the conduction tissues Anatomical record. Part B, New anatomist 2004;280 (1):8-14 [PubMed]
  • Moorman Antoon F. M., Soufan Alexandre T., Hagoort Jaco, de Boer Piet A. J., Christoffels Vincent M. Development of the building plan of the heart Annals of the New York Academy of Sciences 2004;1015:171-181 [PubMed]
  • de Lange Frederik J., Moorman Antoon F. M., Anderson Robert H., Männer Jörg, Soufan Alexandre T., de Gier-de Vries Corrie, Schneider Michael D., Webb Sandra, van den Hoff Maurice J. B., Christoffels Vincent M. Lineage and morphogenetic analysis of the cardiac valves Circulation research 2004;95 (6):645-654 [PubMed]
  • Christoffels Vincent M., Hoogaars Willem M. H., Tessari Alessandra, Clout Danielle E. W., Moorman Antoon F. M., Campione Marina T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers Developmental dynamics 2004;229 (4):763-770 [PubMed]
  • Hoogaars Willem M. H., Tessari Alessandra, Moorman Antoon F. M., de Boer Piet A. J., Hagoort Jaco, Soufan Alexandre T., Campione Marina, Christoffels Vincent M. The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart Cardiovascular research 2004;62 (3):489-499 [PubMed]
  • Streefkerk Jörn O., Hoogaars Willem M. H., Christoffels Vincent M., Sand Carsten, Pfaffendorf Martin, Peters Stephan L. M., van Zwieten Pieter A. Vasopressin-induced vasoconstriction is dependent on MAPK(erk1/2) phosphorylation Fundamental & clinical pharmacology 2004;18 (1):45-50 [PubMed]

2003

  • de Lange Frederik J., Moorman Antoon F. M., Christoffels Vincent M. Atrial cardiomyocyte-specific expression of Cre recombinase driven by an Nppa gene fragment Genesis (New York, N.Y. 2003;37 (1):1-4 [PubMed]
  • Moorman Antoon F. M., Christoffels Vincent M. Cardiac chamber formation: development, genes, and evolution Physiological reviews 2003;83 (4):1223-1267 [PubMed]
  • Habets Petra E. M. H., Clout Danielle E. W., Lekanne Deprez Ronald H., van Roon Marian A., Moorman Antoon F. M., Christoffels Vincent M. Cardiac expression of Gal4 causes cardiomyopathy in a dose-dependent manner Journal of muscle research and cell motility 2003;24 (2-3):205-209 [PubMed]
  • Fijnvandraat Arnoud C., van Ginneken Antoni C. G., de Boer Piet A. J., Ruijter Jan M., Christoffels Vincent M., Moorman Antoon F. M., Lekanne Deprez Ronald H. Cardiomyocytes derived from embryonic stem cells resemble cardiomyocytes of the embryonic heart tube Cardiovascular research 2003;58 (2):399-409 [PubMed]
  • Fijnvandraat Arnoud C., van Ginneken Antoni C. G., Schumacher Cees A., Boheler Kenneth R., Lekanne Deprez Ronald H., Christoffels Vincent M., Moorman Antoon F. M. Cardiomyocytes purified from differentiated embryonic stem cells exhibit characteristics of early chamber myocardium Journal of molecular and cellular cardiology 2003;35 (12):1461-1472 [PubMed]
  • Moorman Antoon F. M., Christoffels Vincent M. Development of the cardiac conduction system: a matter of chamber developmentin: D. J. Chadwick, J. Goode, editors. Development of the cardiac conduction system. Chichester: John Wiley; 2003. p. 25-34; discussion 34-43, 276-9
  • Habets P. E. M. H., Moorman A. F. M., Christoffels V. M. Expression systems to analyze transgenes in the heartin: C. Ince, editors. The physiological genomics of the critically ill mouse. Amsterdam: Kluwer Academic Publishers; 2003. p. 201-210, ISBN 9781402076411
  • Habets Petra E. M. H., Moorman Antoon F. M., Christoffels Vincent M. Regulatory modules in the developing heart Cardiovascular research 2003;58 (2):246-263 [PubMed]
  • Fijnvandraat Arnoud C., Lekanne Deprez Ronald H., Christoffels Vincent M., Ruijter Jan M., Moorman Antoon F. M. TBX5 overexpression stimulates differentiation of chamber myocardium in P19C16 embryonic carcinoma cells Journal of muscle research and cell motility 2003;24 (2-3):211-218 [PubMed]

2002

  • Habets Petra E. M. H., Moorman Antoon F. M., Clout Danielle E. W., van Roon Marian A., Lingbeek Merel, van Lohuizen Maarten, Campione Marina, Christoffels Vincent M. Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation Genes & development 2002;16 (10):1234-1246 [PubMed]
  • Houweling Arjan C., Somi Semir, van den Hoff Maurice J. B., Moorman Antoon F. M., Christoffels Vincent M. Developmental pattern of ANF gene expression reveals a strict localization of cardiac chamber formation in chicken Anatomical record 2002;266 (2):93-102 [PubMed]
  • Habets P. E. M. H. The regulation of chamber-specific gene expression in the developing heart 2002. 183p. ISBN 9789090159928. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Moorman A. F. M.; Co-supervisor: Christoffels V. M.)

2001

  • Mummenhoff J., Houweling A. C., Peters T., Christoffels V. M., Rüther U. Expression of Irx6 during mouse morphogenesis Mechanisms of development 2001;103 (1-2):193-195 [PubMed]
  • Houweling A. C., Dildrop R., Peters T., Mummenhoff J., Moorman A. F., Rüther U., Christoffels V. M. Gene and cluster-specific expression of the Iroquois family members during mouse development Mechanisms of development 2001;107 (1-2):169-174 [PubMed]
  • Campione M., Ros M. A., Icardo J. M., Piedra E., Christoffels V. M., Schweickert A., Blum M., Franco D., Moorman A. F. Pitx2 expression defines a left cardiac lineage of cells: evidence for atrial and ventricular molecular isomerism in the iv/iv mice Developmental biology 2001;231 (1):252-264 [PubMed]
  • Moorman A. F., Houweling A. C., de Boer P. A., Christoffels V. M. Sensitive nonradioactive detection of mRNA in tissue sections: novel application of the whole-mount in situ hybridization protocol journal of histochemistry and cytochemistry 2001;49 (1):1-8 [PubMed]

2000

  • Christoffels V. M., Habets P. E., Das A. T., Clout D. E., van Roon M. A., Moorman A. F., Lamers W. H. A single regulatory module of the carbamoylphosphate synthetase I gene executes its hepatic program of expression Journal of biological chemistry 2000;275 (51):40020-40027 [PubMed]
  • Christoffels V. M., Habets P. E., Franco D., Campione M., de Jong F., Lamers W. H., Bao Z. Z., Palmer S., Biben C., Harvey R. P., Moorman A. F. Chamber formation and morphogenesis in the developing mammalian heart Developmental biology 2000;223 (2):266-278 [PubMed]
  • Christoffels V. M., Keijser A. G., Houweling A. C., Clout D. E., Moorman A. F. Patterning the embryonic heart: identification of five mouse Iroquois homeobox genes in the developing heart Developmental biology 2000;224 (2):263-274 [PubMed]
  • Moorman A. F., Schumacher C. A., de Boer P. A., Hagoort J., Bezstarosti K., van den Hoff M. J., Wagenaar G. T., Lamers J. M., Wuytack F., Christoffels V. M., Fiolet J. W. Presence of functional sarcoplasmic reticulum in the developing heart and its confinement to chamber myocardium Developmental biology 2000;223 (2):279-290 [PubMed]

1999

  • Christoffels V. M., Sassi H., Ruijter J. M., Moorman A. F., Grange T., Lamers W. H. A mechanistic model for the development and maintenance of portocentral gradients in gene expression in the liver Hepatology (Baltimore, Md.) 1999;29 (4):1180-1192 [PubMed]
  • Abdullah Abu Musa D. M., Kobayashi K., Yasuda I., Iijima M., Christoffels V. M., Tomomura M., Horiuchi M., Ohnishi T., Kajihara T., Daikuhara Y., Lamers W. H., Saheki T. Involvement of a cis-acting element in the suppression of carbamoyl phosphate synthetase I gene expression in the liver of carnitine-deficient mice Molecular genetics and metabolism 1999;68 (3):346-356 [PubMed]

1998

  • Christoffels V. M., Grange T., Kaestner K. H., Cole T. J., Darlington G. J., Croniger C. M., Lamers W. H. Glucocorticoid receptor, C/EBP, HNF3, and protein kinase A coordinately activate the glucocorticoid response unit of the carbamoylphosphate synthetase I gene Molecular and cellular biology 1998;18 (11):6305-6315 [PubMed]
  • Kimura T., Christoffels V. M., Chowdhury S., Iwase K., Matsuzaki H., Mori M., Lamers W. H., Darlington G. J., Takiguchi M. Hypoglycemia-associated hyperammonemia caused by impaired expression of ornithine cycle enzyme genes in C/EBPalpha knockout mice Journal of biological chemistry 1998;273 (42):27505-27510 [PubMed]

1996

  • Christoffels V. M., van den Hoff M. J., Lamers M. C., van Roon M. A., de Boer P. A., Moorman A. F., Lamers W. H. The upstream regulatory region of the carbamoyl-phosphate synthetase I gene controls its tissue-specific, developmental, and hormonal regulation in vivo Journal of biological chemistry 1996;271 (49):31243-31250 [PubMed]

1995

  • van den Hoff M. J., Christoffels V. M., Labruyère W. T., Moorman A. F., Lamers W. H. Electrotransfection with "intracellular" buffer Methods in molecular biology (Clifton, N.J.) 1995;48:185-197 [PubMed]
  • Christoffels V. M., van den Hoff M. J., Moorman A. F., Lamers W. H. The far-upstream enhancer of the carbamoyl-phosphate synthetase I gene is responsible for the tissue specificity and hormone inducibility of its expression Journal of biological chemistry 1995;270 (42):24932-24940 [PubMed]

1994

  • KOK R. G., Christoffels V. M., VOSMAN B., Hellingwerf K. J. A gene of Acinetobacter calcoaceticus BD413 encodes a periplasmic peptidyl-prolyl cis-trans isomerase of the cyclophilin sub-class that is not essential for growth BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1994;1219 (3):601-606 [PubMed]

1993

  • KOK R. G., Christoffels V. M., VOSMAN B., Hellingwerf K. J. Growth-phase-dependent expression of the lipolytic system of Acinetobacter calcoaceticus BD413: cloning of a gene encoding one of the esterases Journal of general microbiology 1993;139 (10):2329-2342 [PubMed]
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