Prof. W.J. de Jonge PhD publications

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Publications Prof. W.J. de Jonge PhD

Position
Full Professor
Main activities
Education, Research
Specialisation
Mucosal Immunology, Neurogastroenterology
Focus of research

The group of Wouter de Jonge studies mechanisms of functional and inflammatory gastro-intestinal disease.

-Preclinical research models for gastrointestinal Disease (IBD, irritable bowel syndrome (IBS), and motility disorders)

-Preclinical and Clinical research in surgical complications, wound healing and anastomotic healing

-Specialized medical nutrition to improve gut epithelial barriers and immunity - in alliance with industrial partners 

-Epigenetic aspects of cell differentiation in the gut in health and disease

 

link to our group website:

http://gut-research.com

 



 

2020

  • de Krijger Manon, Visseren Thijmen, Wildenberg Manon E., Hooijer Gerrit K. J., Verstegen Monique M. A., van der Laan Luc J. W., de Jonge Wouter J., Verheij Joanne, Ponsioen Cyriel Y. Characterization of gut-homing molecules in non-endstage livers of patients with primary sclerosing cholangitis and inflammatory bowel disease Journal of Translational Autoimmunity 2020;3 [PubMed]
  • van Helsdingen Claire Pm, Jongen Audrey Chm, de Jonge Wouter J., Bouvy Nicole D., Derikx Joep Pm Consensus on the definition of colorectal anastomotic leakage: A modified Delphi study World journal of gastroenterology 2020;26 (23):3293-3303 [PubMed]
  • Botschuijver Sara Gut fungi in irritable bowel syndrome: A painful recognition 2020. 236p. ISBN 9789402818871. [UvA Dissertations Online] University of Amsterdam. (Supervisors: de Jonge Wouter .J,; Co-supervisors: Seppen Jurgen.E., van den Wijngaard Renoldus M. J. G. J.)
  • Erkelens Martje N., Goverse Gera, Konijn Tanja, Molenaar Rosalie, Beijer Marieke R., van den Bossche Jan, de Goede Kyra E., Verberk Sanne G. S., de Jonge Wouter J., den Haan Joke M. M., Mebius Reina E. Intestinal Macrophages Balance Inflammatory Expression Profiles via Vitamin A and Dectin-1-Mediated Signaling Frontiers in immunology 2020;11 [PubMed]
  • van Thiel Isabelle A. M., de Jonge Wouter J., Chiu Isaac M., van den Wijngaard Rene M. Microbiota-neuroimmune cross talk in stress-induced visceral hypersensitivity of the bowel American journal of physiology. Gastrointestinal and liver physiology 2020;318 (6):G1034-G1041 [PubMed]
  • van Thiel I. A. M., Botschuijver S., de Jonge W. J., Seppen J. Painful interactions: Microbial compounds and visceral pain BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2020;1866 (1) [PubMed]
  • Peters Emmeline G., Pattamatta Madhuri, Smeets Boudewijn J. J., Brinkman Daan J., Evers Silvia M. A. A., de Jonge Wouter J., Hiligsmann Mickaël, Luyer Misha D. P. The clinical and economical impact of postoperative ileus in patients undergoing colorectal surgery Neurogastroenterology and motility 2020;32 (8) [PubMed]

2019

  • Willemze Rose A., Brinkman David J., Welting Olaf, van Hamersveld Patricia H. P., Verseijden Caroline, Luyer Misha D., Wildenberg Manon E., Seppen Jurgen, de Jonge Wouter J. Acetylcholine-producing T cells augment innate immune-driven colitis but are redundant in T cell-driven colitis American journal of physiology. Gastrointestinal and liver physiology 2019;317 (5):G557-G568 [PubMed]
  • de Vries L. C. S., Duarte J. M., de Krijger M., Welting O., van Hamersveld P. H. P., van Leeuwen-Hilbers F. W. M., Moerland P. D., Jongejan A., D'Haens G. R., de Jonge W. J., Wildenberg M. E. A JAK1 Selective Kinase Inhibitor and Tofacitinib Affect Macrophage Activation and Function Inflammatory bowel diseases 2019;25 (4):647-660 [PubMed]
  • Willemze Rose A. Connecting innervation and intestinal inflammation 2019. 191p. ISBN 9789461829443. [UvA Dissertations Online] University of Amsterdam. (Supervisor: de Jonge W. J.; Co-supervisor: Seppen J. E.)
  • Willemze Rose A, Welting Olaf, van Hamersveld Patricia, Verseijden Caroline, Nijhuis Laurens E, Hilbers Francisca W, Meijer Sybren L, Heesters Balthasar A, Folgering Joost H A, Darwinkel Harold, Blancou Philippe, Vervoordeldonk Margriet J, Seppen Jurgen, Heinsbroek Sigrid E M, de Jonge Wouter J Loss of intestinal sympathetic innervation elicits an innate immune driven colitis Molecular medicine (Cambridge, Mass.) 2019;25 (1):1 [PubMed]
  • Chen Hung-Jen, Li Yim Andrew Y. F., Griffith Guillermo R., de Jonge Wouter J., Mannens Marcel M. A. M., Ferrero Enrico, Henneman Peter, de Winther Menno P. J. Meta-Analysis of in vitro-Differentiated Macrophages Identifies Transcriptomic Signatures That Classify Disease Macrophages in vivo Frontiers in immunology 2019;10 [PubMed]
  • Botschuijver Sara, van Diest Sophie A., van Thiel Isabelle A. M., Saia Rafael S., Strik Anne S., Yu Zhumei, Maria-Ferreira Daniele, Welting Olaf, Keszthelyi Daniel, Jennings Gary, Heinsbroek Sigrid E. M., Elferink Ronald P. Oude, Schuren Frank H. J., de Jonge Wouter J., van den Wijngaard René M. Miltefosine treatment reduces visceral hypersensitivity in a rat model for irritable bowel syndrome via multiple mechanisms Scientific reports 2019;9 (1) [PubMed]
  • Brinkman David J, Ten Hove Anne S, Vervoordeldonk Margriet J, Luyer Misha D, de Jonge Wouter J Neuroimmune Interactions in the Gut and Their Significance for Intestinal Immunity Cells 2019;8 (7) [PubMed]
  • Hong Gun-Soo, Zillekens Anne, Schneiker Bianca, Pantelis Dimitrios, de Jonge Wouter, Schaefer Nico, Kalff Joerg C., Wehner Sven Non-invasive transcutaneous auricular vagus nerve stimulation prevents postoperative ileus and endotoxemia in mice Neurogastroenterology and motility 2019;31 (3) [PubMed]
  • de Krijger Manon, Wildenberg Manon E., de Jonge Wouter J., Ponsioen Cyriel Y. Return to sender: Lymphocyte trafficking mechanisms as contributors to primary sclerosing cholangitis Journal of hepatology 2019;71 (3):603-615 [PubMed]
  • Luque-Martin Rosario, van den Bossche Jan, Furze Rebecca C., Neele Annette E., van der Velden Saskia, Gijbels Marion J. J., van Roomen Cindy P. P. A., Bernard Sharon G., de Jonge Wouter J., Rioja Inmaculada, Prinjha Rab K., Lewis Huw D., Mander Palwinder K., de Winther Menno P. J. Targeting histone deacetylases in myeloid cells inhibits their maturation and inflammatory function with limited effects on atherosclerosis Frontiers in pharmacology 2019;10 (OCT) [PubMed]
  • van Diest Sophie A. The pain behind visceral hypersensitivity in IBS 2019. 147p. ISBN 9789402815498. [UvA Dissertations Online] University of Amsterdam. (Supervisor: de Jonge W. J.; Co-supervisor: van den Wijngaard R. M. J. G. J.)

2018

  • Li Yim Andrew Y F, de Bruyn Jessica R, Duijvis Nicolette W, Sharp Catriona, Ferrero Enrico, de Jonge Wouter J, Wildenberg Manon E, Mannens Marcel M A M, Buskens Christianne J, D'Haens Geert R, Henneman Peter, Te Velde Anje A A distinct epigenetic profile distinguishes stenotic from non-inflamed fibroblasts in the ileal mucosa of Crohn's disease patients PLoS ONE 2018;13 (12):e0209656 [PubMed]
  • Smeets Boudewijn J. J., Peters Emmeline G., Horsten Eelco C. J., Weijs Teus J., Rutten Harm J. T., Buurman Willem A., de Jonge Wouter J., Luyer Misha D. P. Effect of Early vs Late Start of Oral Intake on Anastomotic Leakage Following Elective Lower Intestinal Surgery: A Systematic Review Nutrition in clinical practice 2018;33 (6):803-812 [PubMed]
  • Schilderink Ronald Epigenetic mechanisms regulating the inflammatory response 2018. ISBN 9789402810196. [UvA Dissertations Online] University of Amsterdam. (Supervisor: de Jonge W. J.; Co-supervisor: de Winther M. P. J.)
  • Duijvis Nicolette W. IBD therapy redesigned: From established therapeutic regimens to prospective epigenetic approaches 2018. 192p. ISBN 9789402812756. [UvA Dissertations Online] University of Amsterdam. (Supervisors: de Jonge W. J., D'Haens G. R. A. M. , Löwenberg M.; Co-supervisor: te Velde A. A.)
  • Willemze R. A., Welting O., van Hamersveld H. P., Meijer S. L., Folgering J. H. A., Darwinkel H., Witherington J., Sridhar A., Vervoordeldonk M. J., Seppen J., de Jonge W. J. Neuronal control of experimental colitis occurs via sympathetic intestinal innervation Neurogastroenterology and motility 2018;30 (3):e13163 [PubMed]
  • Fornai M., van den Wijngaard R. M., Antonioli L., Pellegrini C., Blandizzi C., de Jonge W. J. Neuronal regulation of intestinal immune functions in health and disease Neurogastroenterology and motility 2018;30 (12):e13406 [PubMed]
  • Peters Emmeline G., Smeets Boudewijn J. J., Nors Jesper, Back Christian M., Funder Jonas A., Sommer Thorbjørn, Laurberg Søren, Løve Uffe S., Leclercq Wouter K. G., Slooter Gerrit D., de Vries Reilingh Tammo S., Wegdam Johannes A., Nieuwenhuijzen Grard A. P., Hiligsmann Mickaël, Buise Marc P., Buurman Willem A., de Jonge Wouter J., Rutten Harm J. T., Luyer Misha D. P. Perioperative lipid-enriched enteral nutrition versus standard care in patients undergoing elective colorectal surgery (SANICS II): a multicentre, double-blind, randomised controlled trial lancet. Gastroenterology & hepatology 2018;3 (4):242-251 [PubMed]
  • Botschuijver S., Welting O., Levin E., Maria-Ferreira D., Koch E., Montijn R. C., Seppen J., Hakvoort T. B. M., Schuren F. H. J., de Jonge W. J., van den Wijngaard R. M. Reversal of visceral hypersensitivity in rat by Menthacarin , a proprietary combination of essential oils from peppermint and caraway, coincides with mycobiome modulation Neurogastroenterology and motility 2018;30 (6):e13299 [PubMed]
  • Smeets Boudewijn J. J., Brinkman David J., Horsten Eelco C. J., Langius Jacqueline A. E., Rutten Harm J. T., de Jonge Wouter J., Luyer Misha D. P. The Effect of Myopenia on the Inflammatory Response Early after Colorectal Surgery Nutrition and cancer 2018;70 (3):460-466 [PubMed]
  • Willemze Rose A., Bakker Tinka, Pippias Maria, Ponsioen Cyriel Y., de Jonge Wouter J. β-Blocker use is associated with a higher relapse risk of inflammatory bowel disease: a Dutch retrospective case-control study European journal of gastroenterology & hepatology 2018;30 (2):161-166 [PubMed]

2017

  • Warners M. J., Vlieg-Boerstra B. J., Verheij J., van Rhijn B. D., van Ampting M. T. J., Harthoorn L. F., de Jonge W. J., Smout A. J. P. M., Bredenoord A. J. Elemental diet decreases inflammation and improves symptoms in adult eosinophilic oesophagitis patients Alimentary pharmacology & therapeutics 2017;45 (6):777-787 [PubMed]
  • Warners Marijn J., Vlieg-Boerstra Berber J., Verheij Joanne, van Hamersveld Patricia H. P., van Rhijn Bram D., van Ampting Marleen T. J., Harthoorn Lucien F., de Jonge Wouter J., Smout Andreas J. P. M., Bredenoord Albert J. Esophageal and Small Intestinal Mucosal Integrity in Eosinophilic Esophagitis and Response to an Elemental Diet American journal of gastroenterology 2017;112 (7):1061-1071 [PubMed]
  • Zhao Jing Gene-expression profiling to reveal pathogenic mechanisms in disease 2017. 163p. ISBN 9789462997202. [UvA Dissertations Online] University of Amsterdam. (Supervisor: de Jonge W. J.; Co-supervisors: Lamers W. H., Hakvoort T. B. M.)
  • van Dijk Irene A., Ferrando Maria Laura, van der Wijk Anne-Eva, Hoebe Ron A., Nazmi Kamran, de Jonge Wouter J., Krawczyk Przemek M., Bolscher Jan G. M., Veerman Enno C. I., Stap Jan Human salivary peptide histatin-1 stimulates epithelial and endothelial cell adhesion and barrier function FASEB journal 2017;31 (9):3922-3933 [PubMed]
  • Duijvis Nicolette W., Moerland Perry D., Kunne Cindy, Slaman Monique M. W., van Dooren Faas H., Vogels Esther W., de Jonge Wouter J., Meijer Sybren L., Fluiter Kees, te Velde Anje A. Inhibition of miR-142-5P ameliorates disease in mouse models of experimental colitis PLoS ONE 2017;12 (10):e0185097 [PubMed]
  • Botschuijver Sara, Roeselers Guus, Levin Evgeni, Jonkers Daisy M., Welting Olaf, Heinsbroek Sigrid E. M., de Weerd Heleen H., Boekhout Teun, Fornai Matteo, Masclee Ad A., Schuren Frank H. J., de Jonge Wouter J., Seppen Jurgen, van den Wijngaard René M. Intestinal Fungal Dysbiosis Is Associated With Visceral Hypersensitivity in Patients With Irritable Bowel Syndrome and Rats Gastroenterology 2017;153 (4):1026-1039 [PubMed]
  • Dhawan Shobhit Neural regulation of innate and adaptive immunity in the gut 2017. 189p. ISBN 9789462955462. [UvA Dissertations Online] University of Amsterdam. (Supervisor: de Jonge W. J.; Co-supervisor: van den Wijngaard R. M. J. G. J.)
  • van der Mark Vincent A., Ghiboub Mohammed, Marsman Casper, Zhao Jing, van Dijk Remco, Hiralall Johan K., Ho-Mok Kam S., Castricum Zoë, de Jonge Wouter J., Oude Elferink Ronald P. J., Paulusma Coen C. Phospholipid flippases attenuate LPS-induced TLR4 signaling by mediating endocytic retrieval of Toll-like receptor 4 Cellular and molecular life sciences 2017;74 (4):715-730 [PubMed]
  • van der Mark Vincent A., Ghiboub Mohammed, Marsman Casper, Zhao Jing, van Dijk Remco, Hiralall Johan K., Ho-Mok Kam S., Castricum Zoë, de Jonge Wouter J., Elferink Ronald P. J. Oude, Paulusma Coen C. Phospholipid flippases attenuate LPS-induced TLR4 signaling by mediating endocytic retrieval of Toll-like receptor 4 (vol 74, pg 715, 2017) Cellular and molecular life sciences 2017;74 (7):1365 [PubMed]
  • Peters E. G., Dekkers M., van Leeuwen-Hilbers F. W., Daams F., Hulsewé K. W. E., de Jonge W. J., Buurman W. A., Luyer M. D. P. Relation between postoperative ileus and anastomotic leakage after colorectal resection: a post hoc analysis of a prospective randomized controlled trial Colorectal disease 2017;19 (7):667-674 [PubMed]
  • de Vries Leonie, Wildenberg Manon, de Jonge Wouter, D'Haens Geert The Future of Janus Kinase Inhibitors in Inflammatory Bowel Disease Journal of Crohn s & colitis 2017;11 (7):885-893 [PubMed]

2016

  • Dhawan Shobhit, de Palma Giada, Willemze Rose A., Hilbers Francisca W., Verseijden Caroline, Luyer Misha D., Nuding Sabine, Wehkamp Jan, Souwer Yuri, de Jong Esther C., Seppen J., van den Wijngaard René M., Wehner Sven, Verdu Elena, Bercik Premek, de Jonge Wouter J. Acetylcholine-producing T cells in the intestine regulate antimicrobial peptide expression and microbial diversity American journal of physiology. Gastrointestinal and liver physiology 2016;311 (5):G920-G933 [PubMed]
  • Bernink Jochem H., Spits Hergen, de Jonge Wouter J. A new edge to immune surveillance by the neural system Cell research 2016;26 (11):1178-1179 [PubMed]
  • Schilderink Ronald, Bell Matthew, Reginato Eleonora, Patten Chris, Rioja Inmaculada, Hilbers Francisca W., Kabala Pawel A., Reedquist Kris A., Tough David F., Tak Paul Peter, Prinjha Rab K., de Jonge Wouter J. BET bromodomain inhibition reduces maturation and enhances tolerogenic properties of human and mouse dendritic cells Molecular immunology 2016;79:66-76 [PubMed]
  • Zweers Serge J., Shiryaev Alexey, Komuta Mina, Vesterhus Mette, Hov Johannes R., Perugorria Maria J., de Waart D. Rudi, Chang Jung-Chin, Tol Shanna, te Velde Anje A., de Jonge Wouter J., Banales Jesus M., Roskams Tania, Beuers Ulrich, Karlsen Tom H., Jansen Peter L., Schaap Frank G. Elevated interleukin-8 in bile of patients with primary sclerosing cholangitis Liver international 2016;36 (9):1370-1377 [PubMed]
  • Pellegrini C., Colucci R., Antonioli L., Barocelli E., Ballabeni V., Bernardini N., Blandizzi C., de Jonge W. J., Fornai M. Intestinal dysfunction in Parkinson's disease: Lessons learned from translational studies and experimental models Neurogastroenterology and motility 2016;28 (12):1781-1791 [PubMed]
  • Heinsbroek S. E. M., Squadrito M. L., Schilderink R., Hilbers F. W., Verseijden C., Hofmann M., Helmke A., Boon L., Wildenberg M. E., Roelofs J. J. T. H., Ponsioen C. Y., Peters C. P., te Velde A. A., Gordon S., de Palma M., de Jonge W. J. miR-511-3p, embedded in the macrophage mannose receptor gene, contributes to intestinal inflammation Mucosal immunology 2016;9 (4):960-973 [PubMed]
  • Li Yim Andrew Y. F., Duijvis Nicolette W., Zhao Jing, de Jonge Wouter J., D'Haens Geert R. A. M., Mannens Marcel M. A. M., Mul Adri N. P. M., te Velde Anje A., Henneman Peter Peripheral blood methylation profiling of female Crohn's disease patients Clinical epigenetics 2016;8:65 [PubMed]
  • Schilderink Ronald, Verseijden Caroline, Seppen Jurgen, Muncan Vanesa, van den Brink Gijs R., Lambers Tim T., van Tol Eric A., de Jonge Wouter J. The SCFA butyrate stimulates the epithelial production of retinoic acid via inhibition of epithelial HDAC American journal of physiology. Gastrointestinal and liver physiology 2016;310 (11):G1138-G1146 [PubMed]
  • Olivier Brenda J., Cailotto Cathy, van der Vliet Jan, Knippenberg Marlene, Greuter Mascha J., Hilbers Francisca W., Konijn Tanja, te Velde Anje A., Nolte Martijn A., Boeckxstaens Guy E., de Jonge Wouter J., Mebius Reina E. Vagal innervation is required for the formation of tertiary lymphoid tissue in colitis European journal of immunology 2016;46 (10):2467-2480 [PubMed]

2015

  • Dhawan S., Hiemstra I. H., Verseijden C., Hilbers F. W., te Velde A. A., Willemsen L. E. M., Stap J., den Haan J. M., de Jonge W. J. Cholinergic receptor activation on epithelia protects against cytokine-induced barrier dysfunction Acta physiologica (Oxford, England) 2015;213 (4):846-859 [PubMed]
  • Hamers Anouk A. J., van Dam Laura, Teixeira Duarte José M., Vos Mariska, Marinković Goran, van Tiel Claudia M., Meijer Sybren L., van Stalborch Anne-Marieke, Huveneers Stephan, te Velde Anje A., de Jonge Wouter J., de Vries Carlie J. M. Deficiency of Nuclear Receptor Nur77 Aggravates Mouse Experimental Colitis by Increased NFκB Activity in Macrophages PLoS ONE 2015;10 (8):e0133598 [PubMed]
  • van Diest Sophie A., van den Elsen Lieke W. J., Klok Allison J., Welting Olaf, Hilbers Francisca W., van de Heijning Bert J., Gaemers Ingrid C., Boeckxstaens Guy E., Werner Maria F., Willemsen Linette E. M., de Jonge Wouter J., van den Wijngaard René M. Dietary Marine n-3 PUFAs Do Not Affect Stress-Induced Visceral Hypersensitivity in a Rat Maternal Separation Model Journal of nutrition 2015;145 (5):915-922 [PubMed]
  • van Rhijn Bram D., Verheij Joanne, van den Bergh Weerman Marius A., Verseijden Caroline, van den Wijngaard René M. J. G. J., de Jonge Wouter J., Smout Andreas J. P. M., Bredenoord Albert J. Histological Response to Fluticasone Propionate in Patients With Eosinophilic Esophagitis Is Associated With Improved Functional Esophageal Mucosal Integrity American journal of gastroenterology 2015;110 (9):1289-1297 [PubMed]
  • Willemze Rose A., Luyer Misha D., Buurman Wim A., de Jonge Wouter J. Neural reflex pathways in intestinal inflammation: hypotheses to viable therapy Nature reviews. Gastroenterology & hepatology 2015;12 (6):353-362 [PubMed]
  • Heinsbroek Sigrid E. M., Williams David L., Welting Olaf, Meijer Sybren L., Gordon Siamon, de Jonge Wouter J. Orally delivered β-glucans aggravate dextran sulfate sodium (DSS)-induced intestinal inflammation Nutrition research (New York, N.Y.) 2015;35 (12):1106-1112 [PubMed]
  • van den Heijkant T. C., Costes L. M. M., van der Lee D. G. C., Aerts B., Osinga-de Jong M., Rutten H. R. M., Hulsewé K. W. E., de Jonge W. J., Buurman W. A., Luyer M. D. P. Randomized clinical trial of the effect of gum chewing on postoperative ileus and inflammation in colorectal surgery British journal of surgery 2015;102 (3):202-211 [PubMed]
  • Kooijman Sander, de Jonge Wouter J., Rensen Patrick C. N. Reply to "Letter to the editor: Parasympathetic innervation of the rodent spleen?" American journal of physiology. Heart and circulatory physiology 2015;309 (12):H2159 [PubMed]
  • Peters E. G., de Jonge W. J., Smeets B. J. J., Luyer M. D. P. The contribution of mast cells to postoperative ileus in experimental and clinical studies Neurogastroenterology and motility 2015;27 (6):743-749 [PubMed]
  • Peters Emmeline G., Smeets Boudewijn J. J., Dekkers Marloes, Buise Marc D., de Jonge Wouter J., Slooter Gerrit D., Reilingh Tammo S. de Vries, Wegdam Johannes A., Nieuwenhuijzen Grard A. P., Rutten Harm J. T., de Hingh Ignace H. J. T., Hiligsmann Mickael, Buurman Wim A., Luyer Misha D. P. The effects of stimulation of the autonomic nervous system via perioperative nutrition on postoperative ileus and anastomotic leakage following colorectal surgery (SANICS II trial): a study protocol for a double-blind randomized controlled trial Trials 2015;16 (1):20 [PubMed]
  • Glowka T. R., Steinebach A., Stein K., Schwandt T., Lysson M., Holzmann B., Tsujikawa K., de Jonge W. J., Kalff J. C., Wehner S. The novel CGRP receptor antagonist BIBN4096BS alleviates a postoperative intestinal inflammation and prevents postoperative ileus Neurogastroenterology and motility 2015;27 (7):1038-1049 [PubMed]

2014

  • Nijhuis Laurens E., Olivier Brenda J., Dhawan Shobit, Hilbers Francisca W., Boon Louis, Wolkers Monika C., Samsom Janneke N., de Jonge Wouter J. Adrenergic β2 receptor activation stimulates anti-inflammatory properties of dendritic cells in vitro PLoS ONE 2014;9 (1):e85086 [PubMed]
  • Weijenborg Pim W., Smout André J. P. M., Verseijden Caroline, van Veen Henk A., Verheij Joanne, de Jonge Wouter J., Bredenoord Albert J. Hypersensitivity to acid is associated with impaired esophageal mucosal integrity in patients with gastroesophageal reflux disease with and without esophagitis American journal of physiology. Gastrointestinal and liver physiology 2014;307 (3):G323-G329 [PubMed]
  • Stoffels Burkhard, Hupa Kristof Johannes, Snoek Susanne A., van Bree Sjoerd, Stein Kathy, Schwandt Timo, Vilz Tim O., Lysson Mariola, Veer Cornelis Van't, Kummer Markus P., Hornung Veit, Kalff Joerg C., de Jonge Wouter J., Wehner Sven Postoperative ileus involves interleukin-1 receptor signaling in enteric glia Gastroenterology 2014;146 (1):176-87.e1 [PubMed]
  • van Rhijn Bram D., Weijenborg Pim W., Verheij Joanne, van den Bergh Weerman Marius A., Verseijden Caroline, van den Wijngaard René M. J. G. J., de Jonge Wouter J., Smout Andreas J. P. M., Bredenoord Albert J. Proton pump inhibitors partially restore mucosal integrity in patients with proton pump inhibitor-responsive esophageal eosinophilia but not eosinophilic esophagitis Clinical gastroenterology and hepatology 2014;12 (11):1815-23.e2 [PubMed]

2013

  • Schilderink R., Verseijden C., de Jonge W. J. Dietary inhibitors of histone deacetylases in intestinal immunity anc homeostasis Frontiers in immunology 2013;4:UNSP 226 [PubMed]
  • Schilderink R., Verseijden C., de Jonge W. J. Erratum: Dietary Inhibitors of Histone Deacetylases in Intestinal Immunity and Homeostasis Frontiers in immunology 2013;4:414 [PubMed]
  • van Bree Sjoerd H. W., Gomez-Pinilla Pedro Julian, van de Bovenkamp Fleur Suzanne, Di Giovangiulio Martina, Farro Giovanna, Nemethova Andrea, Cailotto Cathy, de Jonge Wouter J., Lee Kevin, Ramirez-Molina Cesar, Lugo Dave, Skynner Michael J., Boeckxstaens Guy E. E., Matteoli Gianluca Inhibition of spleen tyrosine kinase as treatment of postoperative ileus Gut 2013;62 (11):1581-1590 [PubMed]
  • de Haan Jacco J., Hadfoune M.'hamed, Lubbers Tim, Hodin Caroline, Lenaerts Kaatje, Ito Akihiko, Verbaeys Isabelle, Skynner Michael J., Cailotto Cathy, van der Vliet Jan, de Jonge Wouter J., Greve Jan-Willem M., Buurman Wim A. Lipid-rich enteral nutrition regulates mucosal mast cell activation via the vagal anti-inflammatory reflex American journal of physiology. Gastrointestinal and liver physiology 2013;305 (5):G383-G391 [PubMed]
  • Costes Léa M. M., Boeckxstaens Guy E., de Jonge Wouter J., Cailotto Cathy Neural networks in intestinal immunoregulation Organogenesis 2013;9 (3):216-223 [PubMed]
  • Stanisor Oana I., van Diest Sophie A., Yu Zhumei, Welting Olaf, Bekkali Noor, Shi Jing, de Jonge Wouter J., Boeckxstaens Guy E., van den Wijngaard Rene M. Stress-induced visceral hypersensitivity in maternally separated rats can be reversed by peripherally restricted histamine-1-receptor antagonists PLoS ONE 2013;8 (6):e66884 [PubMed]
  • van den Wijngaard R. M., Stanisor O. I., van Diest S. A., Welting O., Wouters M. M., Cailotto C., de Jonge W. J., Boeckxstaens G. E. Susceptibility to stress induced visceral hypersensitivity in maternally separated rats is transferred across generations Neurogastroenterology and motility 2013;25 (12):e780-e790 [PubMed]
  • de Jonge Wouter J. The Gut's Little Brain in Control of Intestinal Immunity ISRN gastroenterology 2013;2013:630159 [PubMed]

2012

  • Dhawan Shobhit, Cailotto Cathy, Harthoorn Lucien F., de Jonge Wouter J. Cholinergic signalling in gut immunity Life sciences 2012;91 (21-22):1038-1042 [PubMed]
  • Heinsbroek Sigrid E. M., Oei Anneke, Roelofs Joris J. T. H., Dhawan Shobhit, te Velde Anje, Gordon Siamon, de Jonge Wouter J. Genetic deletion of dectin-1 does not affect the course of murine experimental colitis BMC gastroenterology 2012;12 (1):33 [PubMed]
  • de Winter Benedicte Y., van den Wijngaard Rene M., de Jonge Wouter J. Intestinal mast cells in gut inflammation and motility disturbances BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2012;1822 (1):66-73 [PubMed]
  • Snoek S. A., Dhawan S., van Bree S. H., Cailotto C., van Diest S. A., Duarte J. M., Stanisor O. I., Hilbers F. W., Nijhuis L., Koeman A., van den Wijngaard R. M., Zuurbier C. J., Boeckxstaens G. E., de Jonge W. J. Mast cells trigger epithelial barrier dysfunction, bacterial translocation and postoperative ileus in a mouse model Neurogastroenterology and motility 2012;24 (2):172-E91 [PubMed]
  • van der Zanden Esmerij P., Hilbers Francisca W., Verseijden Caroline, van den Wijngaard Rene M., Skynner Mike, Lee Kevin, Ulloa Luis, Boeckxstaens Guy E., de Jonge Wouter J. Nicotinic Acetylcholine Receptor Expression and Susceptibility to Cholinergic Immunomodulation in Human Monocytes of Smoking Individuals Neuroimmunomodulation 2012;19 (4):255-265 [PubMed]
  • van den Wijngaard R. M., Stanisor O. I., van Diest S. A., Welting O., Wouters M. M., de Jonge W. J., Boeckxstaens G. E. Peripheral a-helical CRF (9-41) does not reverse stress-induced mast cell dependent visceral hypersensitivity in maternally separated rats Neurogastroenterology and motility 2012;24 (3):274-E111 [PubMed]
  • van Diest Sophie A., Stanisor Oana I., Boeckxstaens Guy E., de Jonge Wouter J., van den Wijngaard René M. Relevance of mast cell-nerve interactions in intestinal nociception BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2012;1822 (1):74-84 [PubMed]
  • de Jonge Wouter J., van den Wijngaard René M. Special issue on mast cells in inflammation Preface BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2012;1822 (1):1 [PubMed]

2011

  • The F. O., Cailotto C., van der Vliet J., de Jonge W. J., Bennink R. J., Buijs R. M., Boeckxstaens G. E. Central activation of the cholinergic anti-inflammatory pathway reduces surgical inflammation in experimental post-operative ileus British journal of pharmacology 2011;163 (5):1007-1016 [PubMed]
  • van Bree Sjoerd, Vlug Malaika, Bemelman Willem, Hollmann Markus, Ubbink Dirk, Zwinderman Koos, de Jonge Wouter, Snoek Susanne, Bolhuis Karen, van der Zanden Esmerij, The Frans, Bennink Roel, Boeckxstaens Guy Faster recovery of gastrointestinal transit after laparoscopy and fast-track care in patients undergoing colonic surgery Gastroenterology 2011;141 (3):872-880.e1-4 [PubMed]
  • de Jonge Wouter J. Mast cells in intestinal inflammation, barrier function, and postoperative motility Journal of pediatric gastroenterology and nutrition 2011;53 (Suppl. 2):S56-S57 [PubMed]
  • Snoek Susanne A. Neuro-immunity in intestinal disease. In vivo studies of postoperative ileus and colitis 2011. 131p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Boeckxstaens G. E.; Co-supervisor: de Jonge W. J.)
  • van der Zanden Esmerij P. M. The vagus nerve as a modulator of intestinal inflammation 2011. 165p. ISBN 9789090261935. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Boeckxstaens G. E. E.; Co-supervisor: de Jonge W. J.)
  • van Diest Sophie A., Stanisor Oana I., de Jonge Wouter J., Boeckxstaens Guy E., van den Wijngaard René M. Visceral hypersensitivity in IBS: from bench to bedside Journal of pediatric gastroenterology and nutrition 2011;53 (Suppl. 2):S34-S35 [PubMed]

2010

  • Verstege Marleen I. Epithelial barrier and dendritic cell function in the intestinal mucosas.l: 2010. 244p. ISBN 9789085705666. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Boeckxstaens G. E.; Co-supervisors: te Velde A. A., de Jonge W. J.)
  • van Dop Willemijn A., Heijmans Jarom, Büller Nikè V. J. A., Snoek Susanne A., Rosekrans Sanne L., Wassenberg Elisabeth A., van den Bergh Weerman Marius A., Lanske Beate, Clarke Alan R., Winton Douglas J., Wijgerde Mark, Offerhaus G. Johan, Hommes Daan W., Hardwick James C., de Jonge Wouter J., Biemond Izak, van den Brink Gijs R. Loss of Indian Hedgehog activates multiple aspects of a wound healing response in the mouse intestine Gastroenterology 2010;139 (5):1665-76, 1676.e1-10 [PubMed]
  • Nijhuis Laurens E. J., Olivier Brenda J., de Jonge Wouter J. Neurogenic regulation of dendritic cells in the intestine Biochemical pharmacology 2010;80 (12):2002-2008 [PubMed]
  • Snoek Susanne A., Borensztajn Keren S., van den Wijngaard René M., de Jonge Wouter J. Neuropeptide Receptors in Intestinal Disease: Physiology and Therapeutic Potential Current pharmaceutical design 2010;16 (9):1091-1105 [PubMed]
  • van den Wijngaard René M., Klooker Tamira K., de Jonge Wouter J., Boeckxstaens Guy E. Peripheral relays in stress-induced activation of visceral afferents in the gut Autonomic neuroscience 2010;153 (1-2):99-105 [PubMed]
  • Snoek Susanne A., Verstege Marleen I., van der Zanden Esmerij P., Deeks Nigel, Bulmer David C., Skynner Michael, Lee Kevin, te Velde Anje A., Boeckxstaens Guy E., de Jonge Wouter J. Selective alpha7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis British journal of pharmacology 2010;160 (2):322-333 [PubMed]
  • Snoek Susanne A., Verstege Marleen I., Boeckxstaens Guy E., van den Wijngaard René M., de Jonge Wouter J. The enteric nervous system as a regulator of intestinal epithelial barrier function in health and disease Expert review of gastroenterology & hepatology 2010;4 (5):637-651 [PubMed]
  • Peña Geber, Cai Bolin, Liu Jun, van der Zanden Esmerij P., Deitch Edwin A., de Jonge Wouter J., Ulloa Luis Unphosphorylated STAT3 modulates alpha7 nicotinic receptor signaling and cytokine production in sepsis European journal of immunology 2010;40 (9):2580-2589 [PubMed]

2009

  • Cai Bolin, Chen Fei, Ji Yan, Kiss Levente, de Jonge Wouter J., Conejero-Goldberg Concepcion, Szabo Csaba, Deitch Edwin A., Ulloa Luis Alpha7 cholinergic-agonist prevents systemic inflammation and improves survival during resuscitation Journal of cellular and molecular medicine 2009;13 (9B):3774-3785 [PubMed]
  • van de Pavert Serge A., Olivier Brenda J., Goverse Gera, Vondenhoff Mark F., Greuter Mascha, Beke Patrick, Kusser Kim, Höpken Uta E., Lipp Martin, Niederreither Karen, Blomhoff Rune, Sitnik Kasia, Agace William W., Randall Troy D., de Jonge Wouter J., Mebius Reina E. Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation Nature immunology 2009;10 (11):1193-1199 [PubMed]
  • van den Wijngaard R. M., Klooker T. K., Welting O., Stanisor O. I., Wouters M. M., van der Coelen D., Bulmer D. C., Peeters P. J., Aerssens J., de Hoogt R., Lee K., de Jonge W. J., Boeckxstaens G. E. Essential role for TRPV1 in stress-induced (mast cell-dependent) colonic hypersensitivity in maternally separated rats Neurogastroenterology and motility 2009;21 (10):1107-1e94 [PubMed]
  • Boeckxstaens G. E., de Jonge W. J. Neuroimmune mechanisms in postoperative ileus Gut 2009;58 (9):1300-1311 [PubMed]
  • de Jonge Wouter J., The Frans O., Löwenberg Mark, Boeckxstaens Guy E. P38 MAPK Inhibitor Semapimod Reduces Postoperative Ileus Via Peripheral and Central Mechanisms Gastroenterology 2009;136 (5):1841-1842 [PubMed]
  • van den Wijngaard R. M., Welting O., Bulmer D. C., Wouters M. M., Lee K., de Jonge W. J., Boeckxstaens G. E. Possible role for TRPV1 in neomycin-induced inhibition of visceral hypersensitivity in rat Neurogastroenterology and motility 2009;21 (8):863-e60 [PubMed]
  • van Maanen Marjolein A., Stoof Susanne P., van der Zanden Esmerij P., de Jonge Wouter J., Janssen Richard A., Fischer David F., Vandeghinste Nick, Brys Reginald, Vervoordeldonk Margriet J., Tak Paul P. The alpha7 nicotinic acetylcholine receptor on fibroblast-like synoviocytes and in synovial tissue from rheumatoid arthritis patients: A possible role for a key neurotransmitter in synovial inflammation Arthritis and rheumatism 2009;60 (5):1272-1281 [PubMed]
  • The Frans O., Buist Marrije R., Lei Aaltje, Bennink Roelof J., Hofland Jan, van den Wijngaard René M., de Jonge Wouter J., Boeckxstaens Guy E. The role of mast cell stabilization in treatment of postoperative ileus: a pilot study American journal of gastroenterology 2009;104 (9):2257-2266 [PubMed]
  • van der Zanden E. P., Boeckxstaens G. E., de Jonge W. J. The vagus nerve as a modulator of intestinal inflammation Neurogastroenterology and motility 2009;21 (1):6-17 [PubMed]
  • van der Zanden Esmerij P., Snoek Susanne A., Heinsbroek Sigrid E., Stanisor Oana I., Verseijden Caroline, Boeckxstaens Guy E., Peppelenbosch Maikel P., Greaves David R., Gordon Siamon, de Jonge Wouter J. Vagus nerve activity augments intestinal macrophage phagocytosis via nicotinic acetylcholine receptor alpha4beta2 Gastroenterology 2009;137 (3):1029-1039, 1039.e1-4 [PubMed]

2008

  • de Jonge Wouter J., Greaves David R. Immune modulation in gastrointestinal disorders: new opportunities for therapeutic peptides? Expert review of gastroenterology & hepatology 2008;2 (6):741-748 [PubMed]
  • The F. O., Bennink R. J., Ankum W. M., Buist M. R., Busch O. R. C., Gouma D. J., van der Heide S., van den Wijngaard R. M., de Jonge W. J., Boeckxstaens G. E. Intestinal handling-induced mast cell activation and inflammation in human postoperative ileus Gut 2008;57 (1):33-40 [PubMed]
  • The Frans O. Pathophhysiology of postoperative ileus: from bench to bedside 2008. 256p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Boeckxstaens G. E. E.; Co-supervisor: de Jonge W. J.)
  • Luiking Yvette C., Hallemeesch Marcella M., van de Poll Marcel C., Dejong Cornelis H. C., de Jonge Wouter J., Lamers Wouter H., Deutz Nicolaas E. P. Reduced citrulline availability by OTC deficiency in mice is related to reduced nitric oxide production American journal of physiology. Endocrinology and metabolism 2008;295 (6):E1315-E1322 [PubMed]

2007

  • The Frans O., Boeckxstaens Guy E., Snoek Susanne A., Cash Jenna L., Bennink Roel, Larosa Gregory J., van den Wijngaard Rene M., Greaves David R., de Jonge Wouter J. Activation of the cholinergic anti-inflammatory pathway ameliorates postoperative ileus in mice Gastroenterology 2007;133 (4):1219-1228 [PubMed]
  • de Jonge W. J., Ulloa L. The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation British journal of pharmacology 2007;151 (7):915-929 [PubMed]

2005

  • Boeckxstaens Guy E., de Jonge Wouter, van den Wijngaard René M., Benninga Marc A. Achalasia: From new insights in pathophysiology to treatment Journal of pediatric gastroenterology and nutrition 2005;41 (Suppl. 1):S36-S37 [PubMed]
  • Welting O., van den Wijngaard R. M., de Jonge W. J., Holman R., Boeckxstaens G. E. Assessment of visceral sensitivity using radio telemetry in a rat model of maternal separation Neurogastroenterology and motility 2005;17 (6):838-845 [PubMed]
  • de Jonge Wouter J., The Frans O., van der Zanden Esmerij P., van den Wijngaard René M., Boeckxstaens Guy E. Inflammation and gut motility; Neural control of intestinal immune cell activation Journal of pediatric gastroenterology and nutrition 2005;41 (Suppl. 1):S10-S11 [PubMed]
  • de Lorijn F., de Jonge W. J., Wedel T., Vanderwinden J. M., Benninga M. A., Boeckxstaens G. E. Interstitial cells of Cajal are involved in the afferent limb of the rectoanal inhibitory reflex Gut 2005;54 (8):1107-1113 [PubMed]
  • van den Wijngaard René, Welting Olaf, de Jonge Wouter, Boeckxstaens Guy Parental care, mast cells and visceral hypersensitivity Journal of pediatric gastroenterology and nutrition 2005;41 (Suppl. 1):S12-S13 [PubMed]
  • de Jonge Wouter J., van der Zanden Esmerij P., The Frans O., Bijlsma Maarten F., van Westerloo David J., Bennink Roelof J., Berthoud Hans-Rudolf, Uematsu Satoshi, Akira Shizuo, van den Wijngaard Rene M., Boeckxstaens Guy E. Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway Nature immunology 2005;6 (8):844-851 [PubMed]
  • de Jonge W. J., van der Zanden E. P., O The F., Bijlsma M. F., van Westerloo D. J., Bennink R. J., Berthoud H. R., Uematsu S., Akira S., van den Wijngaard R. M., Boeckxstaens G. E. Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway (vol 6, pg 844, 2005) Nature immunology 2005;6 (9):954
  • The Frans O., de Jonge Wouter J., Bennink Roel J., van den Wijngaard Rene M., Boeckxstaens Guy E. The ICAM-1 antisense oligonucleotide ISIS-3082 prevents the development of postoperative ileus in mice British journal of pharmacology 2005;146 (2):252-258 [PubMed]

2004

  • Bennink Roelof J., van Montfrans Catherine, de Jonge Wouter J., de Bruin Kora, van Deventer Sander J., te Velde Anje A. Imaging of intestinal lymphocyte homing by means of pinhole SPECT in a TNBS colitis mouse model Nuclear medicine and biology 2004;31 (1):93-101 [PubMed]
  • van Montfrans Catherine, Bennink Roelof J., de Bruin Kora, de Jonge Wouter, Verberne Hein J., ten Kate Fiebo J. W., van Deventer Sander J. H., te Velde Anje A. In vivo evaluation of 111In-labeled T-lymphocyte homing in experimental colitis Journal of nuclear medicine 2004;45 (10):1759-1765 [PubMed]
  • de Jonge Wouter J., The Frans O., van der Coelen Dennis, Bennink Roelof J., Reitsma Pieter H., van Deventer Sander J., van den Wijngaard René M., Boeckxstaens Guy E. Mast cell degranulation during abdominal surgery initiates postoperative ileus in mice Gastroenterology 2004;127 (2):535-545 [PubMed]

2003

  • Hallemeesch Marcella M., Janssen Ben J. A., de Jonge Wouter J., Soeters Peter B., Lamers Wouter H., Deutz Nicolaas E. P. NO production by cNOS and iNOS reflects blood pressure changes in LPS-challenged mice American journal of physiology. Endocrinology and metabolism 2003;285 (4):E871-E875 [PubMed]
  • de Jonge Wouter J., van den Wijngaard René M., The Frans O., ter Beek Merel-Linde, Bennink Roel J., Tytgat Guido N. J., Buijs Ruud M., Reitsma Pieter H., van Deventer Sander J., Boeckxstaens Guy E. Postoperative ileus is maintained by intestinal immune infiltrates that activate inhibitory neural pathways in mice Gastroenterology 2003;125 (4):1137-1147 [PubMed]
  • Bennink Roelof J., de Jonge Wouter J., Symonds Erin L., van den Wijngaard Rene M., Spijkerboer Astrid L., Benninga Marc A., Boeckxstaens Guy E. Validation of gastric-emptying scintigraphy of solids and liquids in mice using dedicated animal pinhole scintigraphy Journal of nuclear medicine 2003;44 (7):1099-1104 [PubMed]

2002

  • de Jonge Wouter J., Kwikkers Karin L., te Velde Anje A., van Deventer Sander J. H., Nolte Martijn A., Mebius Reina E., Ruijter Jan M., Lamers Marinus C., Lamers Wouter H. Arginine deficiency affects early B cell maturation and lymphoid organ development in transgenic mice Journal of clinical investigation 2002;110 (10):1539-1548 [PubMed]
  • de Jonge Wouter J., Hallemeesch Marcella M., Kwikkers Karin L., Ruijter Jan M., de Gier-de Vries Corrie, van Roon Marian A., Meijer Alfred J., Marescau Bart, de Deyn Peter P., Deutz Nicolaas E. P., Lamers Wouter H. Overexpression of arginase I in enterocytes of transgenic mice elicits a selective arginine deficiency and affects skin, muscle, and lymphoid development American journal of clinical nutrition 2002;76 (1):128-140 [PubMed]

2001

  • de Jonge W. J., Marescau B., D'Hooge R., de Deyn P. P., Hallemeesch M. M., Deutz N. E., Ruijter J. M., Lamers W. H. Overexpression of arginase alters circulating and tissue amino acids and guanidino compounds and affects neuromotor behavior in mice Journal of nutrition 2001;131 (10):2732-2740 [PubMed]

2000

  • Boeckxstaens G. E., Hollmann M., Heisterkamp S. H., Robberecht P., de Jonge W. J., van den Wijngaard R. M., Tytgat G. N., Blommaart P. J. Evidence for VIP(1)/PACAP receptors in the afferent pathway mediating surgery-induced fundic relaxation in the rat British journal of pharmacology 2000;131 (4):705-710 [PubMed]
  • Origin of biquadratic exchange in Fe/Si/Fe Physical review letters 2000;84 (8):1812-1815 [PubMed]

1999

  • Post-transcriptional regulation of the arginine transporter Cat-1 by amino acid availability Journal of biological chemistry 1999;274 (43):30424-30432 [PubMed]

1998

  • Arginine-metabolizing enzymes in the developing rat small intestine Pediatric research 1998;43 (4 Part 1):442-451 [PubMed]
  • Metabolism to a response pathway selective retinoid ligand during axial pattern formation Proceedings of the National Academy of Sciences of the United States of America 1998;95 (26):15424-15429 [PubMed]

1996

  • Analysis of scattering lengths in Co/Cu/Co and Co/Cu/Co/Cu spin-valves using a Ru barrier Physical review. B, Condensed matter 1996;54 (13):9365-9371 [PubMed]
  • Development of the ornithine cycle in rat liver: zonation of a metabolic pathway Hepatology (Baltimore, Md.) 1996;24 (2):407-411 [PubMed]

Corona-maatregelen

We zetten ons in om ons ziekenhuis veilig te houden tijdens de coronacrisis.

Lees deze extra maatregelen goed door voordat u een van onze locaties bezoekt: