R.M. van Hest PhD publications

2021

• de Vroom Suzanne L., van Daalen Frederike V., Zieck Saskia E., Mathôt Ron A. A., van Hest Reinier M., Geerlings Suzanne E. Does dose reduction of renally cleared antibiotics in patients with impaired renal function lead to adequate drug exposure? A systematic review Clinical microbiology and infection 2021 [PubMed]
• Preijers Tim, Schütte Lisette M., Kruip Marieke J. H. A., Cnossen Marjon H., Leebeek Frank W. G., van Hest Reinier M., Mathôt Ron A. A. Population Pharmacokinetics of Clotting Factor Concentrates and Desmopressin in Hemophilia Clinical pharmacokinetics 2021;60 (1) [PubMed]

2020

• Spriet Isabel, van Hest Reinier M., Peetermans Willy E., Debaveye Yves Comment on: Effectiveness and safety of an institutional aminoglycoside-based regimen as empirical treatment of patients with pyelonephritis Journal of antimicrobial chemotherapy 2020;75 (12):3696-3697 [PubMed]
• Guo Tingjie, van Hest Reinier M., Zwep Laura B., Roggeveen Luca F., Fleuren Lucas M., Bosman Rob J., van der Voort Peter H. J., Girbes Armand R. J., Mathot Ron A. A., Elbers Paul W. G., van Hasselt Johan G. C. Correction to: Optimizing Predictive Performance of Bayesian Forecasting for Vancomycin Concentration in Intensive Care Patients (10.1007/s11095-20-02908-7) Pharmaceutical research 2020;37 (11)
• Jager Nynke G. L., van Hest Reinier M., Xie Jiao, Wong Gloria, Ulldemolins Marta, Brüggemann Roger J. M., Lipman Jeffrey, Roberts Jason A. Optimization of flucloxacillin dosing regimens in critically ill patients using population pharmacokinetic modelling of total and unbound concentrations Journal of antimicrobial chemotherapy 2020;75 (9):2641-2649 [PubMed]
• Guo Tingjie, van Hest Reinier M., Zwep Laura B., Roggeveen Luca F., Fleuren Lucas M., Bosman Rob J., van der Voort Peter H. J., Girbes Armand R. J., Mathot Ron A. A., Elbers Paul W. G., van Hasselt Johan G. C. Optimizing Predictive Performance of Bayesian Forecasting for Vancomycin Concentration in Intensive Care Patients Pharmaceutical research 2020;37 (9) [PubMed]
• de Vroom Suzanne L., van Hest Reinier M., van Daalen Frederike V., Kuil Sacha D., Mathôt Ron A. A., Geerlings Suzanne E., Jager Nynke G. L. Pharmacokinetic/pharmacodynamic target attainment of ciprofloxacin in adult patients on general wards with adequate and impaired renal function International journal of antimicrobial agents 2020;56 (5) [PubMed]
• Krens Stefanie D., Hodiamont Caspar J., Juffermans Nicole P., Mathôt Ron A. A., van Hest Reinier M. Population Pharmacokinetics of Ganciclovir in Critically Ill Patients Therapeutic drug monitoring 2020;42 (2):295-301 [PubMed]
• van den Broek Annemieke K., van Hest Reinier M., Lettinga Kamilla D., Jimmink Afra, Lauw Fanny N., Visser Caroline E., Prins Jan M. The appropriateness of antimicrobial use in the outpatient clinics of three hospitals in the Netherlands Antimicrobial resistance and infection control 2020;9 (1) [PubMed]
• Schütte Lisette M., van Hest Reinier M., Cnossen Marjon H., Stoof Sara C. M., Leebeek Frank W. G., Mathôt Ron A. A., Kruip Marieke J. H. A. The association between desmopressin exposure, FVIII response and side effects Haemophilia 2020 [PubMed]
• Guo Tingjie, van Hest Reinier M., Fleuren Lucas M., Roggeveen Luca F., Bosman Rob J., van der Voort Peter H. J., Girbes Armand R. J., Mathot Ron A. A., van Hasselt Johan G. C., Elbers Paul W. G. Why we should sample sparsely and aim for a higher target: Lessons from model-based therapeutic drug monitoring of vancomycin in intensive care patients British journal of clinical pharmacology 2020 [PubMed]

2019

• Jager Nynke G. L., van Hest Reinier M., Lipman Jeffrey, Roberts Jason A., Cotta Menino O. Antibiotic exposure at the site of infection: principles and assessment of tissue penetration Expert review of clinical pharmacology 2019;12 (7):623-634 [PubMed]
• Schütte Lisette M., de Rooij Nils, Hazendonk Hendrika C. A. M., Mathôt Ron A. A., van Hest Reinier M., Leebeek Frank W. G., Cnossen Marjon H., Kruip Marieke J. H. A. Current dosing practices for perioperative factor VIII concentrate treatment in mild haemophilia A patients result in FVIII levels above target Haemophilia 2019 [PubMed]
• Schütte Lisette M., Cnossen Marjon H., van Hest Reinier M., Driessens Mariette H. E., Fijnvandraat Karin, Polinder Suzanne, Beckers Erik A. M., Coppens Michiel, Eikenboom Jeroen, Laros-van Gorkom Britta A. P., Meijer Karina, Nieuwenhuizen Laurens, Mauser-Bunschoten Evelien P., Leebeek Frank W. G., Mathôt Ron A. A., Kruip Marieke J. H. A. Desmopressin treatment combined with clotting factor VIII concentrates in patients with non-severe haemophilia A: Protocol for a multicentre single-armed trial, the DAVID study BMJ open 2019;9 (4) [PubMed]
• Guo Tingjie, van Hest Reinier M., Roggeveen Luca F., Fleuren Lucas M., Thoral Patrick J., Bosman Rob J., van der Voort Peter H. J., Girbes Armand R. J., Mathot Ron A. A., Elbers Paul W. G. External evaluation of population pharmacokinetic models of vancomycin in large cohorts of intensive care unit patients Antimicrobial agents and chemotherapy 2019;63 (5) [PubMed]
• Bos Jeannet C., Prins Jan M., Mistício Mabor C., Nunguiane Ginto, Lang Cláudia N., Beirão José C., Mathôt Ron A. A., van Hest Reinier M. Population pharmacokinetics with Monte Carlo simulations of gentamicin in a population of severely ill adult patients from sub-Saharan Africa Antimicrobial agents and chemotherapy 2019;63 (4) [PubMed]
• Preijers Tim, Schütte Lisette M., Kruip Marieke J. H. A., Cnossen Marjon H., Leebeek Frank W. G., van Hest Reinier M., Mathôt Ron A. A. Strategies for individualized dosing of clotting factor concentrates and desmopressin in hemophilia A and B Therapeutic drug monitoring 2019;41 (2):192-212 [PubMed]

2018

• Maaskant Jolanda M, Tio Marieke A, van Hest Reinier M, Vermeulen Hester, Geukers Vincent G M Medication audit and feedback by a clinical pharmacist decrease medication errors at the PICU: An interrupted time series analysis Health services research 2018;1 (3):e23 [PubMed]
• Schütte L. M., van Hest R. M., Stoof S. C. M., Leebeek F. W. G., Cnossen M. H., Kruip M. J. H. A., Mathôt R. A. A. Pharmacokinetic Modelling to Predict FVIII:C Response to Desmopressin and Its Reproducibility in Nonsevere Haemophilia A Patients Thrombosis and haemostasis 2018;118 (04):621-629 [PubMed]
• Bos Jeannet C., van Hest Reinier M., Mistício Mabor C., Nunguiane Ginto, Lang Cláudia N., Beirão José C., Mathôt Ron A. A., Prins Jan M. Pharmacokinetics and Pharmacodynamic Target Attainment of Benzylpenicillin in an Adult Severely ill Sub-Saharan African Patient Population Clinical infectious diseases 2018;66 (8):1261–1269 [PubMed]
• Bos Jeannet C., Prins Jan M., Mistício Mabor C., Nunguiane Ginto, Lang Cláudia N., Beirão José C., Mathôt Ron A. A., van Hest Reinier M. Pharmacokinetics and pharmacodynamic target attainment of ceftriaxone in adult severely ill sub-Saharan African patients: A population pharmacokinetic modelling study Journal of antimicrobial chemotherapy 2018;73 (6):1620-1629 [PubMed]
• Bukkems Laura H., Roger Claire, Hodiamont Caspar J., Lefrant Jean-Yves, Juffermans Nicole P., Roberts Jason A., van Hest Reinier M. Predictive performance of a gentamicin population pharmacokinetic model in two western populations of critically ill patients International journal of antimicrobial agents 2018;52 (2):218-225 [PubMed]
• Abdoellakhan Rahat A., Khorsand Nakisa, van Hest Reinier M., Veeger Nic, ter Avest Ewoud, Ypma Paula F., Faber Laura M., Meijer Karina Randomised controlled trial protocol to evaluate a fixed dose prothrombin complex concentrate against the variable dose in Vitamin K antagonist related bleeding (PROPER3) BMJ open 2018;8 (3) [PubMed]

2017

• Deelen Jan W. T., Visser Caroline E., Prins Jan M., van Hest Reinier M. Antimicrobial prophylaxis outside the operating theatre, an audit in a university hospital BMC infectious diseases 2017;17 (1):296 [PubMed]
• Hodiamont Caspar J., Juffermans Nicole P., Bouman Catherine S. C., de Jong Menno D., Mathôt Ron A. A., van Hest Reinier M. Determinants of gentamicin concentrations in critically ill patients: a population pharmacokinetic analysis International journal of antimicrobial agents 2017;49 (2):204-211 [PubMed]
• Bos Jeannet C. Diagnosis and treatment of common infectious diseases in severely ill sub-Saharan African patients: Studies from a hospital floor 2017. 184p. ISBN 9789090304854. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Prins J. M.; Co-supervisor: van Hest R. M.)
• van Daalen F. V., Prins J. M., Opmeer B. C., Boermeester M. A., Visser C. E., van Hest R. M., Branger J., Mattsson E., van de Broek M. F. M., Roeleveld T. C., Karimbeg A. A., Haak E. A. F., van den Hout H. C., van Agtmael M. A., Hulscher M. E. J. L., Geerlings S. E. Effect of an antibiotic checklist on length of hospital stay and appropriate antibiotic use in adult patients treated with intravenous antibiotics: a stepped wedge cluster randomized trial Clinical microbiology and infection 2017;23 (7):485.e1-485.e8 [PubMed]
• Berrevoets Marvin Ah, ten Oever Jaap, Sprong Tom, van Hest Reinier M., Groothuis Ingeborg, van Heijl Inger, Schouten Jeroen A., Hulscher Marlies E., Kullberg Bart-Jan Monitoring, documenting and reporting the quality of antibiotic use in the Netherlands: a pilot study to establish a national antimicrobial stewardship registry BMC infectious diseases 2017;17 (1):565 [PubMed]
• Feng Yanfang, van Hest Reinier M., Hodiamont Caspar J., Brul Stanley, Schultsz Constance, ter Kuile Benno H. Optimization of therapy against Pseudomonas aeruginosa with ceftazidime and meropenem using chemostats as model for infections FEMS microbiology letters 2017;364 (14):fnx142 [PubMed]
• Bos Jeannet C., Mistício Mabor C., Nunguiane Ginto, Mathôt Ron A. A., van Hest Reinier M., Prins Jan M. Paracetamol clinical dosing routine leads to paracetamol underexposure in an adult severely ill sub-Saharan African hospital population: a drug concentration measurement study BMC research notes 2017;10 (1):671 [PubMed]
• Bos Jeannet C., van Hest Reinier M., Prins Jan M. Pharmacokinetics of Antibiotics in Sub-Saharan African Patient Populations: A Systematic Review Therapeutic drug monitoring 2017;39 (4):387-398 [PubMed]
• Hodiamont C. J., Janssen J. M., de Jong M. D., Mathôt R. A., Juffermans N. P., van Hest R. M. Therapeutic Drug Monitoring of Gentamicin Peak Concentrations in Critically Ill Patients Therapeutic drug monitoring 2017;39 (5):522-530 [PubMed]

2016

• Feng Yanfang, Hodiamont Caspar J., van Hest Reinier M., Brul Stanley, Schultsz Constance, ter Kuile Benno H. Development of Antibiotic Resistance during Simulated Treatment of Pseudomonas aeruginosa in Chemostats PLoS ONE 2016;11 (2):e0149310 [PubMed]
• Tio M., Maaskant Jolanda, Vermeulen H., Geukers V., van Hest R. Effect van proactieve participatie door een apotheker op medicatiefouten in een pediatrische intensivecare-unit Pharmaceutisch Weekblad 2016;151 (24):29-33
• Wildenbeest Joanne G., Said Ines, Jaeger Bregje, van Hest Reinier M., van de Beek Diederik, Pajkrt Dasja Neonate with Mycoplasma hominis meningoencephalitis given moxifloxacin Lancet infectious diseases 2016;16 (11):e261-e266 [PubMed]
• Jager Nynke G. L., van Hest Reinier M., Lipman Jeffrey, Taccone Fabio S., Roberts Jason A. Therapeutic drug monitoring of anti-infective agents in critically ill patients Expert review of clinical pharmacology 2016;9 (7):961-979 [PubMed]

2015

• van Daalen Frederike V., Prins Jan M., Opmeer Brent C., Boermeester Marja A., Visser Caroline E., van Hest Reinier M., Hulscher Marlies E. J. L., Geerlings Suzanne E. A cluster randomized trial for the implementation of an antibiotic checklist based on validated quality indicators: the AB-checklist BMC infectious diseases 2015;15 (1):134 [PubMed]
• Khorsand Nakisa, Kooistra Hilde A. M., van Hest Reinier M., Veeger Nic J. G. M., Meijer Karina A systematic review of prothrombin complex concentrate dosing strategies to reverse vitamin K antagonist therapy Thrombosis research 2015;135 (1):9-19 [PubMed]
• van den Hurk G. H. A. M., Janssen J. M., Juffermans N. P., van Hest R. M. De kwaliteit van doseringsadviezen bij therapeutic drug monitoring van aminoglycosiden op de intensive care Pharmaceutisch Weekblad 2015;150:160-164
• Wieske Luuk, van Hest Reinier M., Witteveen Esther, Verhamme Camiel, Schultz Marcus J., van Schaik Ivo N., Horn Janneke Is gentamicin affecting the neuromuscular system of critically ill patients? Intensive care medicine 2015;41 (4):727-728 [PubMed]
• van Vessem Denise J., Juffermans Nicole P., Bouman Catherine S. C., van Hest Reinier M. The Area Under the Concentration-Time Curve Is a Better Estimate for Vancomycin Exposure Than Trough Levels Critical care medicine 2015;43 (9):E401 [PubMed]

2014

• Bikker Pieternella Cornelia Variability in response to antihypertensive drug therapy: From population based therapy towards individualized treatment 2014. 211p. ISBN 9789462594029. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Koopmans R. P., Mathôt R. A. A.; Co-supervisor: van Hest R. M.)

2013

• Khorsand Nakisa, Giepmans Lisette, Meijer Karina, van Hest Reinier M., Veeger Nic J. G. M. A low fixed dose of prothrombin complex concentrate is cost effective in emergency reversal of vitamin K antagonists Haematologica 2013;98 (6):e65-e67 [PubMed]
• van Rijn-Bikker Petra C., Snelder Nelleke, Ackaert Oliver, van Hest Reinier M., Ploeger Bart A., van Montfrans Gert A., Koopmans Richard P., Mathôt Ron A. Nonlinear mixed effects modeling of the diurnal blood pressure profile in a multiracial population American journal of hypertension 2013;26 (9):1103-1113 [PubMed]
• van Rijn-Bikker Petra C., Ackaert Oliver, Snelder Nelleke, van Hest Reinier M., Ploeger Bart A., Koopmans Richard P., Mathôt Ron A. A. Pharmacokinetic-pharmacodynamic modeling of the antihypertensive effect of eprosartan in Black and White hypertensive patients Clinical pharmacokinetics 2013;52 (9):793-803 [PubMed]

2012

• Khorsand Nakisa, Veeger Nic J. G. M., van Hest Reinier M., Ypma Paula F., Heidt Jeroen, Meijer Karina An observational, prospective, two-cohort comparison of a fixed versus variable dosing strategy of prothrombin complex concentrate to counteract vitamin K antagonists in 240 bleeding emergencies Haematologica 2012;97 (10):1501-1506 [PubMed]

2011

• Dunbar R., van Hest R., Lawrence K., Verver S., Enarson D. A., Lombard C., Beyers N., Barnes J. M. Capture-recapture to estimate completeness of tuberculosis surveillance in two communities in South Africa international journal of tuberculosis and lung disease 2011;15 (8):1038-1043 [PubMed]

2010

• de Winter Brenda C. M., Mathot Ron A. A., Sombogaard Ferdi, Neumann Irmgard, van Hest Reinier M., Doorduijn Jeanette K., van Gelder Teun Differences in clearance of mycophenolic acid among renal transplant recipients, hematopoietic stem cell transplant recipients, and patients with autoimmune disease Therapeutic drug monitoring 2010;32 (5):606-614 [PubMed]

2009

• de Winter Brenda C. M., van Gelder Teun, Mathot Ron A. A., Glander Petra, Tedesco-Silva Helio, Hilbrands Luuk, Budde Klemens, van Hest Reinier M. Limited sampling strategies drawn within 3 hours postdose poorly predict mycophenolic acid area-under-the-curve after enteric-coated mycophenolate sodium Therapeutic drug monitoring 2009;31 (5):585-591 [PubMed]
• de Winter Brenda C. M., Neumann Irmgard, van Hest Reinier M., van Gelder Teun, Mathot Ron A. A. Limited sampling strategies for therapeutic drug monitoring of mycophenolate mofetil therapy in patients with autoimmune disease Therapeutic drug monitoring 2009;31 (3):382-390 [PubMed]
• van Hest Reinier M., van Gelder Teun, Vulto Arnold G., Shaw Leslie M., Mathot Ron A. A. Pharmacokinetic modelling of the plasma protein binding of mycophenolic acid in renal transplant recipients Clinical pharmacokinetics 2009;48 (7):463-476 [PubMed]
• de Winter Brenda C. M., van Gelder Teun, Sombogaard Ferdi, Shaw Leslie M., van Hest Reinier M., Mathot Ron A. A. Pharmacokinetic role of protein binding of mycophenolic acid and its glucuronide metabolite in renal transplant recipients Journal of pharmacokinetics and pharmacodynamics 2009;36 (6):541-564 [PubMed]

2008

• de Winter Brenda C. M., van Gelder Teun, Glander Petra, Cattaneo Dario, Tedesco-Silva Helio, Neumann Irmgard, Hilbrands Luuk, van Hest Reinier M., Pescovitz Mark D., Budde Klemens, Mathot Ron A. A. Population pharmacokinetics of mycophenolic acid : a comparison between enteric-coated mycophenolate sodium and mycophenolate mofetil in renal transplant recipients Clinical pharmacokinetics 2008;47 (12):827-838 [PubMed]

2007

• van Hest Reinier M. Individualisation of mycophenolate mofetil therapy 2007. 221p. ISBN 9789090213781. [UvA Dissertations Online] Erasmus University Rotterdam. (Supervisor: Vulto A. G.; Co-supervisors: Mathôt R. A. A., van Gelder T.)
• van Hest Reinier M., Doorduijn Jeanette K., de Winter Brenda C. M., Cornelissen Jan J., Vulto Arnold G., Oellerich Michael, Löwenberg Bob, Mathot Ron A. A., Armstrong Victor William, van Gelder Teun Pharmacokinetics of mycophenolate mofetil in hematopoietic stem cell transplant recipients Therapeutic drug monitoring 2007;29 (3):353-360 [PubMed]
• de Winter Brenda C. M., Mathôt Ron A. A., van Hest Reinier M., van Gelder Teun Therapeutic drug monitoring of mycophenolic acid: does it improve patient outcome? Expert opinion on drug metabolism & toxicology 2007;3 (2):251-261 [PubMed]
• van Hest Reinier M., van Gelder Teun, Bouw René, Goggin Timothy, Gordon Robert, Mamelok Richard D., Mathot Ron A. Time-dependent clearance of mycophenolic acid in renal transplant recipients British journal of clinical pharmacology 2007;63 (6):741-752 [PubMed]

2006

• van Hest Reinier M., Mathot Ron A. A., Pescovitz Mark D., Gordon Robert, Mamelok Richard D., van Gelder Teun Explaining variability in mycophenolic acid exposure to optimize mycophenolate mofetil dosing: a population pharmacokinetic meta-analysis of mycophenolic acid in renal transplant recipients Journal of the American Society of Nephrology 2006;17 (3):871-880 [PubMed]
• van Hest Reinier M., Hesselink Dennis A., Vulto Arnold G., Mathot Ron A. A., van Gelder Teun Individualization of mycophenolate mofetil dose in renal transplant recipients Expert opinion on pharmacotherapy 2006;7 (4):361-376 [PubMed]
• van Hest Reinier M., Mathot Ron A., Vulto Arnold G., Ijzermans Jan N., van Gelder Teun Within-patient variability of mycophenolic acid exposure: therapeutic drug monitoring from a clinical point of view Therapeutic drug monitoring 2006;28 (1):31-34 [PubMed]

2005

• Hesselink Dennis A., van Hest Reinier M., Mathot Ron A. A., Bonthuis Fred, Weimar Willem, de Bruin Ron W. F., van Gelder Teun Cyclosporine interacts with mycophenolic acid by inhibiting the multidrug resistance-associated protein 2 American journal of transplantation 2005;5 (5):987-994 [PubMed]
• van Hest Reinier M., van Gelder Teun, Vulto Arnold G., Mathot Ron A. A. Population pharmacokinetics of mycophenolic acid in renal transplant recipients Clinical pharmacokinetics 2005;44 (10):1083-1096 [PubMed]
• van Hest Reinier, Mathot Ron, Vulto Arnold, Weimar Willem, van Gelder Teun Predicting the usefulness of therapeutic drug monitoring of mycophenolic acid: a computer simulation Therapeutic drug monitoring 2005;27 (2):163-167 [PubMed]

2004

• van Hest Reinier M., Mathôt Ron A. A., Vulto Arnold G., Le Meur Yann, van Gelder Teun Mycophenolic acid in diabetic renal transplant recipients: pharmacokinetics and application of a limited sampling strategy Therapeutic drug monitoring 2004;26 (6):620-625 [PubMed]
• van Gelder Teun, Hesselink Dennis A., van Hest Reinier M., Mathôt Ron A. A., van Schaik Ron Pharmacogenetics in immunosuppressive therapy: the best thing since TDM? Therapeutic drug monitoring 2004;26 (4):343-346 [PubMed]