S. Huveneers PhD publications

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Publications PhD S. Huveneers

Positions
Associate Professor, Research Associate
Main activities
Research
Specialisation
Vascular Microenvironment & Integrity
Focus of research

www.huveneerslab.eu

Endothelial mechanotransduction in inflammation and vascular disease

  • Investigating vascular integrity in inflammation and cardiovascular disease.
  • Elucidating cytoskeletal-mediated cell-cell junction regulation.
  • Understanding how mechanical forces control endothelial adhesions.

2020

  • Poels Kikkie, van Leent Mandy M. T., Reiche Myrthe E., Kusters Pascal J. H., Huveneers Stephan, de Winther Menno P. J., Mulder Willem J. M., Lutgens Esther, Seijkens Tom T. P. Antibody-Mediated Inhibition of CTLA4 Aggravates Atherosclerotic Plaque Inflammation and Progression in Hyperlipidemic Mice Cells 2020;9 (9) [PubMed]
  • Botros Liza, Pronk Manon C. A., Juschten Jenny, Liddle John, Morsing Sofia K. H., van Buul Jaap D., Bates Robert H., Tuinman Pieter R., van Bezu Jan S. M., Huveneers Stephan, Bogaard Harm Jan, van Hinsbergh Victor W. M., Hordijk Peter L., Aman Jurjan Bosutinib prevents vascular leakage by reducing focal adhesion turnover and reinforcing junctional integrity Journal of cell science 2020;133 (9) [PubMed]
  • Malinova Tsveta Broken symmetry and novel molecular players in endothelial adherens junctions 2020. 195p. ISBN 9789463807470. [UvA Dissertations Online] University of Amsterdam. (Supervisor: de Vries Carlie J. M.; Co-supervisors: Huveneers Stephan, Kluza Ewelina)
  • Angulo-Urarte Ana, van der Wal Tanne, Huveneers Stephan Cell-cell junctions as sensors and transducers of mechanical forces BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 2020;1862 (9) [PubMed]
  • Dorland Yvonne. L. Crosstalk in the bone marrow: Interactions of endothelial, hematopoietic and mesenchymal stromal cells 2020. 237p. ISBN 9789463757058. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van der Schoot C. Ellen; Co-supervisors: Huveneers Stephan, Voermans Carlijn)
  • van der Stoel Miesje, Schimmel Lilian, Nawaz Kalim, van Stalborch Anne-Marieke, de Haan Annett, Klaus-Bergmann Alexandra, Valent Erik T., Koenis Duco S., van Nieuw Amerongen Geerten P., de Vries Carlie J., de Waard Vivian, Gloerich Martijn, van Buul Jaap D., Huveneers Stephan DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis Journal of cell science 2020;133 (3) [PubMed]
  • Jones Elizabeth A. V., Graupera Mariona, van Buul Jaap D., Huveneers Stephan Editorial: Endothelial Dynamics in Health and Disease Frontiers in physiology 2020;11 [PubMed]
  • Rademakers Timo, Goedhart Marieke, Hoogenboezem Mark, Ponce Alexander García, van Rijssel Jos, Samus Maryna, Schnoor Michael, Butz Stefan, Huveneers Stephan, Vestweber Dietmar, Nolte Martijn A., Voermans Carlijn, van Buul Jaap D. Hematopoietic stem and progenitor cells use podosomes to transcellularly cross the bone marrow endothelium Haematologica 2020;105 (5):2746-2756 [PubMed]
  • Poels Kikkie, van Leent Mandy M. T., Boutros Celine, Tissot Hubert, Roy S. verine, Meerwaldt Anu E., Toner Yohana C. A., Reiche Myrthe E., Kusters Pascal J. H., Malinova Tsveta, Huveneers Stephan, Kaufman Audrey E., Mani Venkatesh, Fayad Zahi A., de Winther Menno P. J., Marabelle Aurelien, Mulder Willem J. M., Robert Caroline, Seijkens Tom T. P., Lutgens Esther Immune Checkpoint Inhibitor Therapy Aggravates T Cell–Driven Plaque Inflammation in Atherosclerosis JACC: CardioOncology 2020;2 (4):599-610
  • Stanicek Laura, Lozano-Vidal Noelia, Bink Diewertje Ilse, Hooglugt Aukie, Yao Wenjie, Wittig Ilka, van Rijssel Jos, van Buul Jaap Diederik, van Bergen Anke, Klems Alina, Ramms Anne Sophie, le Noble Ferdinand, Hofmann Patrick, Szulcek Robert, Wang ShengPeng, Offermanns Stefan, Ercanoglu Meryem Seda, Kwon Hyouk-Bum, Stainier Didier, Huveneers Stephan, Kurian Leo, Dimmeler Stefanie, Boon Reinier Abraham Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function Communications Biology 2020;3 (1) [PubMed]
  • van der Wijk Anne-Eva, Georgakopoulou Theodosia, Majolée Jisca, van Bezu Jan S. M., van der Stoel Miesje M., van het Hof Bert J., de Vries Helga E., Huveneers Stephan, Hordijk Peter L., Bakker Erik N. T. P., van Bavel Ed Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain Acta neuropathologica communications 2020;8 (1) [PubMed]
  • Tan Josephine Mathilde Elisabeth, van der Stoel Miesje Maxime, van den Berg Marlene, van Loon Nienke Marlies, Moeton Martina, Scholl Edwin, van der Wel Nicole Neeltje, Kovačević Igor, Hordijk Peter Lodewijk, Loregger Anke, Huveneers Stephan, Zelcer Noam The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting Cell reports 2020;32 (5) [PubMed]

2019

  • Goedhart Marieke, Gessel Stephanie, van der Voort Robbert, Slot Edith, Lucas Beth, Gielen Ellis, Hoogenboezem Mark, Rademakers Timo, Geerman Sulima, van Buul Jaap D., Huveneers Stephan, Dolstra Harry, Anderson Graham, Voermans Carlijn, Nolte Martijn A. CXCR4, but not CXCR3, drives CD8 + T-cell entry into and migration through the murine bone marrow European journal of immunology 2019;49 (4):576-589 [PubMed]
  • Brezovjakova H., Tomlinson C., Mohd-Naim N., Swiatlowska P., Erasmus J. E., Huveneers S., Gorelik J., Bruche S., Braga V. M. M. Junction mapper is a novel computer vision tool to decipher cell-cell contact phenotypes eLife 2019;8 [PubMed]
  • Beldman Thijs J., Malinova Tsveta S., Desclos Emilie, Grootemaat Anita E., Misiak Aresh L. S., van der Velden Saskia, van Roomen Cindy P. A. A., Beckers Linda, van Veen Henk A., Krawczyk Przemyslaw M., Hoebe Ron A., Sluimer Judith C., Neele Annette E., de Winther Menno P. J., van der Wel Nicole N., Lutgens Esther, Mulder Willem J. M., Huveneers Stephan, Kluza Ewelina Nanoparticle-Aided Characterization of Arterial Endothelial Architecture during Atherosclerosis Progression and Metabolic Therapy ACS nano 2019;13 (12):13759-13774 [PubMed]
  • Dorland Yvonne L, Cornelissen Anne S, Kuijk Carlijn, Tol Simon, Hoogenboezem Mark, van Buul Jaap D, Nolte Martijn A, Voermans Carlijn, Huveneers Stephan Nuclear shape, protrusive behaviour and in vivo retention of human bone marrow mesenchymal stromal cells is controlled by Lamin-A/C expression Scientific reports 2019;9 (1):14401 [PubMed]
  • Malinova Tsveta S, Huveneers Stephan Opening the vascular gate Nature nanotechnology 2019;14 (3):195-196 [PubMed]
  • Bebelman Maarten P., Bun Philippe, Huveneers Stephan, van Niel Guillaume, Pegtel D. Michiel, Verweij Frederik J. Real-time imaging of multivesicular body–plasma membrane fusion to quantify exosome release from single cells Nature protocols 2019;15 (1):102–121 [PubMed]

2018

  • Angulo-Urarte Ana, Casado Pedro, Castillo Sandra D., Kobialka Piotr, Kotini Maria Paraskevi, Figueiredo Ana M., Castel Pau, Rajeeve Vinothini, Milà-Guasch Maria, Millan Jaime, Wiesner Cora, Serra Helena, Muixi Laia, Casanovas Oriol, Viñals Francesc, Affolter Markus, Gerhardt Holger, Huveneers Stephan, Belting Heinz-Georg, Cutillas Pedro R., Graupera Mariona Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility Nature communications 2018;9 (1):4826 [PubMed]
  • Smeets Michel W. J. Erythrocytes and von Willebrand Factor in Venous Thrombosis 2018. ISBN 9789463610834. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Hordijk P. L.; Co-supervisor: Huveneers S.)
  • Goedhart Marieke, Cornelissen Anne S., Kuijk Carlijn, Geerman Sulima, Kleijer Marion, van Buul Jaap D., Huveneers Stephan, Raaijmakers Marc H. G. P., Young Howard A., Wolkers Monika C., Voermans Carlijn, Nolte Martijn A. Interferon-gamma impairs maintenance and alters hematopoietic support of bone marrow mesenchymal stromal cells Stem cells and development 2018;27 (9):579-589 [PubMed]
  • Koenis Duco Steven, Medzikovic Lejla, van Loenen Pieter Bas, van Weeghel Michel, Huveneers Stephan, Vos Mariska, Evers-van Gogh Ingrid Johanna, van den Bossche Jan, Speijer Dave, Kim Yongsoo, Wessels Lodewyk, Zelcer Noam, Zwart Wilbert, Kalkhoven Eric, de Vries Carlie Jacoba Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism Cell reports 2018;24 (8):2127-2140.e7 [PubMed]
  • Koenis Duco S. Nuclear receptors and their co-factors in hematological and inflammation-driven disorders 2018. ISBN 9789463750202. [UvA Dissertations Online] University of Amsterdam. (Supervisors: de Vries C. J. M., Zelcer N.; Co-supervisors: de Waard V., Huveneers S.)
  • Malinova Tsveta S., Huveneers Stephan Sensing of Cytoskeletal Forces by Asymmetric Adherens Junctions Trends in cell biology 2018;28 (4):328-341 [PubMed]
  • Schimmel Lilian, van der Stoel Miesje, Rianna Carmela, van Stalborch Anne-Marieke, de Ligt Aafke, Hoogenboezem Mark, Tol Simon, van Rijssel Jos, Szulcek Robert, Bogaard Harm Jan, Hofmann Patrick, Boon Reinier, Radmacher Manfred, de Waard Vivian, Huveneers Stephan, van Buul Jaap D. Stiffness-Induced Endothelial DLC-1 Expression Forces Leukocyte Spreading through Stabilization of the ICAM-1 Adhesome Cell reports 2018;24 (12):3115-3124 [PubMed]

2017

  • Dorland Yvonne L., Huveneers Stephan Cell-cell junctional mechanotransduction in endothelial remodeling Cellular and molecular life sciences 2017;74 (2):279-292 [PubMed]

2016

  • Heemskerk Niels, Schimmel Lilian, Oort Chantal, van Rijssel Jos, Yin Taofei, Ma Bin, van Unen Jakobus, Pitter Bettina, Huveneers Stephan, Goedhart Joachim, Wu Yi, Montanez Eloi, Woodfin Abigail, van Buul Jaap D. F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling Nature communications 2016;7:10493 [PubMed]
  • Dorland Yvonne L., Malinova Tsveta S., van Stalborch Anne-Marieke D., Grieve Adam G., van Geemen Daphne, Jansen Nicolette S., de Kreuk Bart-Jan, Nawaz Kalim, Kole Jeroen, Geerts Dirk, Musters René J. P., de Rooij Johan, Hordijk Peter L., Huveneers Stephan The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions Nature communications 2016;7:12210 [PubMed]

2015

  • Timmerman Ilse, Heemskerk Niels, Kroon Jeffrey, Schaefer Antje, van Rijssel Jos, Hoogenboezem Mark, van Unen Jakobus, Goedhart Joachim, Gadella Theodorus W. J., Yin Taofei, Wu Yi, Huveneers Stephan, van Buul Jaap D. A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1 Journal of cell science 2015;128 (16):3041-3054 [PubMed]
  • Timmerman Ilse, Heemskerk Niels, Kroon Jeffrey, Schaefer Antje, van Rijssel Jos, Hoogenboezem Mark, van Unen Jakobus, Goedhart Joachim, Gadella Theodorus W. J., Yin Taofei, Wu Yi, Huveneers Stephan, van Buul Jaap D. A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1 (vol 128, pg 3041, 2015) Journal of cell science 2015;128 (18):3514 [PubMed]
  • Huveneers Stephan, Daemen Mat J. A. P., Hordijk Peter L. Between Rho(k) and a hard place: the relation between vessel wall stiffness, endothelial contractility, and cardiovascular disease Circulation research 2015;116 (5):895-908 [PubMed]
  • Hamers Anouk A. J., van Dam Laura, Teixeira Duarte José M., Vos Mariska, Marinković Goran, van Tiel Claudia M., Meijer Sybren L., van Stalborch Anne-Marieke, Huveneers Stephan, te Velde Anje A., de Jonge Wouter J., de Vries Carlie J. M. Deficiency of Nuclear Receptor Nur77 Aggravates Mouse Experimental Colitis by Increased NFκB Activity in Macrophages PLoS ONE 2015;10 (8):e0133598 [PubMed]
  • Fraccaroli Alessia, Pitter Bettina, Taha Abdallah Abu, Seebach Jochen, Huveneers Stephan, Kirsch Julian, Casaroli-Marano Ricardo P., Zahler Stefan, Pohl Ulrich, Gerhardt Holger, Schnittler Hans-J., Montanez Eloi Endothelial Alpha-Parvin Controls Integrity of Developing Vasculature and Is Required for Maintenance of Cell-Cell Junctions Circulation research 2015;117 (1):29-40 [PubMed]
  • Oldenburg Joppe, van der Krogt Gerard, Twiss Floor, Bongaarts Anika, Habani Yasmin, Slotman Johan A., Houtsmuller Adriaan, Huveneers Stephan, de Rooij Johan VASP, zyxin and TES are tension-dependent members of Focal Adherens Junctions independent of the alpha-catenin-vinculin module Scientific reports 2015;5:17225 [PubMed]

2014

  • van Geemen Daphne, Smeets Michel W. J., van Stalborch Anne-Marieke D., Woerdeman Leonie A. E., Daemen Mat J. A. P., Hordijk Peter L., Huveneers Stephan F-actin-anchored focal adhesions distinguish endothelial phenotypes of human arteries and veins Arteriosclerosis, thrombosis, and vascular biology 2014;34 (9):2059-2067 [PubMed]
  • Hamers Anouk A. J., Uleman Sven, van Tiel Claudia M., Kruijswijk Daniëlle, van Stalborch Anne-Marieke, Huveneers Stephan, de Vries Carlie J. M., van 't Veer Cornelis Limited role of nuclear receptor Nur77 in Escherichia coli-induced peritonitis Infection and immunity 2014;82 (1):253-264 [PubMed]
  • van Buul Jaap D., Geerts Dirk, Huveneers Stephan Rho GAPs and GEFs Controling switches in endothelial cell adhesion Cell adhesion & migration 2014;8 (2):108-124 [PubMed]

2013

  • Huveneers Stephan, de Rooij Johan Mechanosensitive systems at the cadherin-F-actin interface Journal of cell science 2013;126 (2):403-413 [PubMed]

2012

  • Aman Jurjan, van Bezu Jan, Damanafshan Amin, Huveneers Stephan, Eringa Etto C., Vogel Steven M., Groeneveld A. B. Johan, Vonk Noordegraaf Anton, van Hinsbergh Victor W. M., van Nieuw Amerongen Geerten P. Effective treatment of edema and endothelial barrier dysfunction with imatinib Circulation 2012;126 (23):2728-2738 [PubMed]
  • Huveneers Stephan, Oldenburg Joppe, Spanjaard Emma, van der Krogt Gerard, Grigoriev Ilya, Akhmanova Anna, Rehmann Holger, de Rooij Johan Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling Journal of cell biology 2012;196 (5):641-652 [PubMed]
  • Twiss Floor, Le Duc Quint, van der Horst Suzanne, Tabdili Hamid, van der Krogt Gerard, Wang Ning, Rehmann Holger, Huveneers Stephan, Leckband Deborah E., de Rooij Johan Vinculin-dependent Cadherin mechanosensing regulates efficient epithelial barrier formation Biology open 2012;1 (11):1128-U120 [PubMed]

2011

  • Pannekoek Willem-Jan, van Dijk Jantine J. G., Chan On Ying A., Huveneers Stephan, Linnemann Jelena R., Spanjaard Emma, Brouwer Patricia M., van der Meer Anne Jan, Zwartkruis Fried J. T., Rehmann Holger, de Rooij Johan, Bos Johannes L. Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control Cellular signalling 2011;23 (12):2056-2064 [PubMed]

2010

  • Huveneers Stephan, Danen Erik H. J. The Interaction of Src Kinase with beta 3 Integrin Tails: A Potential Therapeutic Target in Thrombosis and Cancer TheScientificWorldJournal 2010;10:1100-1105 [PubMed]

2009

  • Huveneers Stephan, Danen Erik H. J. Adhesion signaling - crosstalk between integrins, Src and Rho Journal of cell science 2009;122 (8):1059-1069 [PubMed]
  • Puigvert Jordi Carreras, Huveneers Stephan, Fredriksson Lisa, op het Veld Marieke, van de Water Bob, Danen Erik H. J. Cross-Talk between Integrins and Oncogenes Modulates Chemosensitivity Molecular pharmacology 2009;75 (4):947-955 [PubMed]

2008

  • Huveneers Stephan, Truong Hoa, Fässler Reinhard, Sonnenberg Arnoud, Danen Erik H. J. Binding of soluble fibronectin to integrin alpha 5 beta 1 - link to focal adhesion redistribution and contractile shape Journal of cell science 2008;121 (15):2452-2462 [PubMed]
  • Huveneers Stephan, Arslan Serdar, van de Water Bob, Sonnenberg Arnoud, Danen Erik H. J. Integrins uncouple src-induced morphological and oncogenic transformation Journal of biological chemistry 2008;283 (19):13243-13251 [PubMed]
  • Huveneers Stephan The regulation of Rho and Src signaling by integrins 2008. 128p. ISBN 9789090234434. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Berns A. J. M.; Co-supervisor: Danen E. H. J.)

2007

  • Huveneers Stephan, van den Bout Iman, Sonneveld Petra, Sancho Ana, Sonnenberg Arnoud, Danen Erik H. J. Integrin alpha(v)beta(3) controls activity and oncogenic potential of primed c-Src Cancer research 2007;67 (6):2693-2700 [PubMed]
  • Huveneers Stephan, Truong Hoa, Danen H. J. Integrins: Signaling, disease, and therapy International journal of radiation biology 2007;83 (11-12):743-751 [PubMed]
  • van den Bout Iman, Truong Hoa H., Huveneers Stephan, Kuikman Ingrid, Danen Erik H. J., Sonnenberg Arnoud The regulation of MacMARCKS expression by integrin beta 3 Experimental cell research 2007;313 (6):1260-1269 [PubMed]

2005

  • Danen Erik H.J., Van Rheenen Jacco, Franken Willeke, Huveneers Stephan, Sonneveld Petra, Jalink Kees, Sonnenberg Arnoud Erratum: (Journal of Cell Biology (May 9, 2005) 169:3 (515-526)) Journal of cell biology 2005;170 (3):497
  • Danen Erik H. J., van Rheenen Jacco, Franken Willeke, Huveneers Stephan, Sonneveld Petra, Jalink Kees, Sonnenberg Arnoud Integrins control motile strategy through a Rho-cofilin pathway Journal of cell biology 2005;169 (3):515-526 [PubMed]

2004

  • Malliri Angeliki, van Es Saskia, Huveneers Stephan, Collard John G. The Rac exchange factor Tiam1 is required for the establishment and maintenance of cadherin-based adhesions Journal of biological chemistry 2004;279 (29):30092-30098 [PubMed]

2002

  • van Oort Erica, de Heer Pleuni G., van Leeuwen W. Astrid, Derksen Ninotska I. L., Müller Marcel, Huveneers Stephan, Aalberse Rob C., van Ree Ronald Maturation of Pichia pastoris-derived recombinant pro-Der p 1 induced by deglycosylation and by the natural cysteine protease Der p 1 from house dust mite European Journal of Biochemistry / FEBS 2002;269 (2):671-679 [PubMed]