S.J. Pinto-Sietsma PhD publications

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Publications PhD S.J. Pinto-Sietsma

Position
Medical Specialist
Main activities
Patient care, Research
Specialisation
vascular medicin with special attention in premature atherosclerose and miRNA research
Focus of research

 

Our focus on research is on premature atherosclerosis.

Fifty percent of all individuals, whom die of cardiovascular disease, are older than 80 years of age. This means, that cardiovascular disease is a disease of older age. Whenever young individuals develop cardiovascular disease, for instance a myocardial infarction at the age of 40 years, this is very unusual. This is called premature atherosclerosis. Likely, this person will have accelerated atherosclerotic disease. Sometimes this occurs in several family member of one family, suggesting a genetic predisposition for accelerate atherosclerotic disease.

Our main focus is on unravelling the underlying mechanisms responsible for accelerate atherosclerosis from an epidemiological, genetic and basic science point of view. Secondly, we try to estimate the risk family members have for accelerated atherosclerosis, since due to their young age the standard risk models cannot be used.

For that matter we have developed a premature atherosclerosis family outpatient clinic, in which we counsel patients and family members on cause, treatment and risk of cardiovascular disease.

 

 

 

Amsterdam UMC Research Institutes
AMC departments
All publications

2021

  • Singh Sandeep, Widrich Christine, Nap Martijn, Schokker Emile, Zwinderman Aeilko H., Pinto-Sietsma Sara-Joan Antihypertensives and their relation to mortality by SARS-CoV-2 infection Journal of medical virology 2021 [PubMed]
  • Singh Sandeep, de Ronde Maurice W. J., Creemers Esther E., van der Made Ingeborg, Meijering Roelien, Chan Mark Y., Hwee Tan Sock, Tang Chin Chee, Mark Richards A., Troughton Richard W., Yean Yip Fong Alan, Yan Bryan P., Pinto-Sietsma Sara-Joan Low miR-19b-1-5p Expression Is Related to Aspirin Resistance and Major Adverse Cardio- Cerebrovascular Events in Patients With Acute Coronary Syndrome Journal of the American Heart Association 2021;10 (2):e017120 [PubMed]

2020

  • Attaye Ilias, Pinto-Sietsma Sara-Joan, Herrema Hilde, Nieuwdorp Max A Crucial Role for Diet in the Relationship between Gut Microbiota and Cardiometabolic Disease Annual review of medicine 2020;71:149-161 [PubMed]
  • Pinto-Sietsma Sara Joan, Flossdorf Michael, Buchholz Veit R., Offerhaus Joost, Bleijendaal Hidde, Beudel Martijn, Volders Paul G.A., Ter Bekke Rachel M.A., Dormans Tom, Zwetsloot Peter Paul, de Jager Peter, Massberg Steffen, Rämer Patrick, Wendtner Clemens, Hoffmann Ellen, Rothe Kathrin, Feihl Susanne, Kessler Thorsten, Pinto Yigal M., Schunkert Heribert Antihypertensive drugs in COVID-19 infection European heart journal. Cardiovascular pharmacotherapy 2020;6 (6):415-416 [PubMed]
  • de Ronde Maurice W. J., Khoshiwal Amir, Planken R. Nils, Boekholdt S. Matthijs, Biemond Mariette, Budoff Matthew J., Cooil Bruce, Lotufo Paulo A., Bensenor Isabela M., Ohmoto-Sekine Yuki, Gudnason Vilmundur, Aspelund Thor, Gudmundsson Elias Freyr, Zwinderman Aeilko H., Raggi Paolo, Pinto-Sietsma Sara-Joan A pooled-analysis of age and sex based coronary artery calcium scores percentiles Journal of cardiovascular computed tomography 2020;14 (5):414-420 [PubMed]
  • Pinto-Sietsma Sara-Joan, Zwinderman Aeilko H., Ophuis Ton Oude Medische tuchtcolleges straffen vaker en strenger Een observationeel onderzoek naar 10 jaar tuchtrecht Nederlands tijdschrift voor geneeskunde 2020;164 (35)
  • Singh Sandeep, de Ronde Maurice W J, Kok Maayke G M, Beijk Marcel Am, De Winter Robbert J, van der Wal Allard C, Sondermeijer Brigitte M, Meijers Joost C M, Creemers Esther E, Pinto-Sietsma Sara-Joan MiR-223-3p and miR-122-5p as circulating biomarkers for plaque instability Open heart 2020;7 (1) [PubMed]
  • Bruikman Caroline S., Vreeken Dianne, Hoogeveen Renate M., Bom Michiel J., Danad Ibrahim, Pinto-Sietsma Sara-Joan, van Zonneveld Anton Jan, Knaapen Paul, Hovingh G. Kees, Stroes Erik S. G., van Gils Janine M. Netrin-1 and the Grade of Atherosclerosis Are Inversely Correlated in Humans Arteriosclerosis, thrombosis, and vascular biology 2020;40 (2):462-472 [PubMed]
  • Gommans D. H. Frank, Nas Joris, Pinto-Sietsma Sara-Joan, Koop Yvonne, Konst Regina E., Mensink Frans, Aarts Goaris W. A., Konijnenberg Lara S. F., Cortenbach Kimberley, Verhaert Dominique V. M., Thannhauser Jos, Mol Jan-Quinten, Rooijakkers Maxim J. P., Vos Jacqueline L., van Rumund Anouke, Vart Priya, Hassing Robert-Jan, Cornel Jan-Hein, de Jager C. Peter C., van den Heuvel Michel M., van der Hoeven Hans G., Verbon Annelies, Pinto Yigal M., van Royen Niels, van Kimmenade Roland R. J., de Leeuw Peter W., van Agtmael Michiel A., Bresser Paul, van Gilst Wiek H., Vonk-Noordergraaf Anton, Tijssen Jan G. P. Rationale and design of the PRAETORIAN-COVID trial: A double-blind, placebo-controlled randomized clinical trial with valsartan for PRevention of Acute rEspiraTORy dIstress syndrome in hospitAlized patieNts with SARS-COV-2 Infection Disease: PRAETORIAN-COVID (NCT04335786) American heart journal 2020;226:60-68 [PubMed]
  • Bruikman Caroline, de Ronde Maurice W. J., Amin Ahmed, Levy Sonja, Lof Pien, de Ruijter Ursula, Hovingh Kees, Tan Hanno L., Pinto-Sietsma Sara-Joan Sudden cardiac death in families with premature cardiovascular disease Heart (British Cardiac Society) 2020;106 (3):228-232 [PubMed]
  • Offringa Annette, Montijn Roy, Singh Sandeep, Paul Martin, Pinto Yigal M., Pinto-Sietsma Sara-Joan The mechanistic overview of SARS-CoV-2 using angiotensin-converting enzyme 2 to enter the cell for replication: possible treatment options related to the renin-angiotensin system European heart journal. Cardiovascular pharmacotherapy 2020;6 (5):317-325 [PubMed]
  • Houttu Veera, Boulund Ulrika, Grefhorst Aldo, Soeters Maarten R., Pinto-Sietsma Sara-Joan, Nieuwdorp Max, Holleboom Adriaan G. The role of the gut microbiome and exercise in non-alcoholic fatty liver disease Therapeutic advances in gastroenterology 2020;13 [PubMed]

2019

  • Singh Sandeep, Desai Rupak, Pinto-Sietsma Sara-Joan Atrial fibrillation in peripheral arterial disease with coexisting coronary artery disease and diabetes mellitus: An intricate association not to be missed! Clinical cardiology 2019 [PubMed]
  • Valerio Luca, Peters Ron J, Zwinderman Aeilko H, Pinto-Sietsma Sara-Joan Reproducibility of sublingual microcirculation parameters obtained from sidestream darkfield imaging PLoS ONE 2019;14 (3):e0213175 [PubMed]
  • Valerio Luca, Peters Ron J, Zwinderman Aeilko H, Pinto-Sietsma Sara-Joan Sublingual endothelial glycocalyx and atherosclerosis. A cross-sectional study PLoS ONE 2019;14 (3):e0213097 [PubMed]

2018

  • de Ronde Maurice W. J. Circulating microRNAs: Methodological solutions to identify biomarkers for cardiovascular disease 2018. ISBN 9789462998476. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Meijers J. C. M.; Co-supervisors: Pinto-Sietsma S. J., Creemers E. E. J. M.)
  • Deschasaux M. lanie, Bouter Kristien E., Prodan Andrei, Levin Evgeni, Groen Albert K., Herrema Hilde, Tremaroli Valentina, Bakker Guido J., Attaye Ilias, Pinto-Sietsma Sara-Joan, van Raalte Daniel H., Snijder Marieke B., Nicolaou Mary, Peters Ron, Zwinderman Aeilko H., Bäckhed Fredrik, Nieuwdorp Max Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography Nature medicine 2018;24 (10):1526-1531 [PubMed]
  • Verweij Simone L., de Ronde Maurice W. J., Verbeek Rutger, Boekholdt S. Matthijs, Planken R. Nils, Stroes Erik S. G., Pinto-Sietsma Sara-Joan Elevated lipoprotein(a) levels are associated with coronary artery calcium scores in asymptomatic individuals with a family history of premature atherosclerotic cardiovascular disease Journal of clinical lipidology 2018;12 (3):597-603.e1 [PubMed]
  • Bayés-Genis Antoni, Lanfear David E., de Ronde Maurice W. J., Lupón Josep, Leenders Joost J., Liu Zhen, Zuithoff Nicolaas P. A., Eijkemans Marinus J. C., Zamora Elisabet, de Antonio Marta, Zwinderman Aeilko H., Pinto-Sietsma Sara-Joan, Pinto Yigal M. Prognostic value of circulating microRNAs on heart failure-related morbidity and mortality in two large diverse cohorts of general heart failure patients European journal of heart failure 2018;20 (1):67-75 [PubMed]
  • Kok M. G. M., de Ronde M. W. J., Moerland P. D., Ruijter J. M., Creemers E. E., Pinto-Sietsma S. J. Small sample sizes in high-throughput miRNA screens: A common pitfall for the identification of miRNA biomarkers Biomolecular Detection and Quantification 2018;15:1-5 [PubMed]
  • de Ronde Maurice W. J., Ruijter Jan M., Moerland Perry D., Creemers Esther E., Pinto-Sietsma Sara-Joan Study design and qPCR data analysis guidelines for reliable circulating miRNA biomarker experiments: A review Clinical chemistry 2018;64 (9):1308-1318 [PubMed]

2017

  • de Ronde Maurice W. J., Kok Maayke G. M., Moerland Perry D., van den Bossche Jan, Neele Annette E., Halliani Amalia, van der Made Ingeborg, de Winther Menno P. J., Meijers Joost C. M., Creemers Esther E., Pinto-Sietsma Sara-Joan High miR-124-3p expression identifies smoking individuals susceptible to atherosclerosis Atherosclerosis 2017;263:377-384 [PubMed]
  • de Ronde Maurice W. J., Ruijter Jan M., Lanfear David, Bayes-Genis Antoni, Kok Maayke G. M., Creemers Esther E., Pinto Yigal M., Pinto-Sietsma Sara-Joan Practical data handling pipeline improves performance of qPCR-based circulating miRNA measurements RNA (New York, N.Y.) 2017;23 (5):811-821 [PubMed]

2016

  • Valerio Luca, Peters Ron J., Zwinderman Aeilko H., Pinto-Sietsma Sara-Joan Association of Family History With Cardiovascular Disease in Hypertensive Individuals in a Multiethnic Population Journal of the American Heart Association 2016;5 (12):e004260 [PubMed]
  • de Ronde Maurice W. J., Pinto Yigal M., Pinto-Sietsma Sara-Joan Circulating microRNA biomarkers for cardiovascular risk prediction: are we approaching clinical application? Annals of translational medicine 2016;4 (24):490 [PubMed]
  • Mulders Ties A., Taraboanta Catalin, Franken Lotte C., van Heel Eddy, Klass Gunter, Forster Bruce B., Arad Yadon, Boekholdt S. Matthijs, Groenink Maarten, Fröhlich Jiri, Guerci Alan D., Stroes Erik S. G., Pinto-Sietsma Sara-Joan Coronary artery calcification score as tool for risk assessment among families with premature coronary artery disease Atherosclerosis 2016;245:155-160 [PubMed]
  • Kok M. G. M., Mandolini C., Moerland P. D., de Ronde M. W. J., Sondermeijer B. M., Halliani A., Nieuwland R., Cipollone F., Creemers E. E., Meijers J. C. M., Pinto-Sietsma S. J. Low miR-19b-1-5p expression in isolated platelets after aspirin use is related to aspirin insensitivity International journal of cardiology 2016;203:262-263 [PubMed]

2015

  • Kok Maayke Guda Maria Circulating microRNAs and other biomarkers for premature atherosclerosis 2015. 141p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Meijers J. C. M.; Co-supervisors: Pinto-Sietsma S. J., Creemers E. E.)
  • Hakimzadeh Nazanin, Nossent A. Yaël, van der Laan Anja M., Schirmer Stephan H., de Ronde Maurice W. J., Pinto-Sietsma Sara-Joan, van Royen Niels, Quax Paul H. A., Hoefer Imo E., Piek Jan J. Circulating MicroRNAs Characterizing Patients with Insufficient Coronary Collateral Artery Function PLoS ONE 2015;10 (9):e0137035 [PubMed]
  • Kok Maayke G. M., Halliani Amalia, Moerland Perry D., Meijers Joost C. M., Creemers Esther E., Pinto-Sietsma Sara-Joan Normalization panels for the reliable quantification of circulating microRNAs by RT-qPCR FASEB journal 2015;29 (9):3853-3862 [PubMed]

2014

  • Kok M. G. M., Meijers J. C. M., Pinto-Sietsma S.-J. Individuals with coronary artery disease at a young age and features of the metabolic syndrome have an increased prothrombotic potential Thrombosis and haemostasis 2014;111 (3):458-464 [PubMed]
  • Martin-Ramirez Javier, Kok Maayke G. M., Hofman Menno, Bierings Ruben, Creemers Esther E., Meijers Joost C. M., Voorberg Jan, Pinto-Sietsma Sara-Joan Individual with subclinical atherosclerosis have impaired proliferation of blood outgrowth endothelial cells, which can be restored by statin therapy PLoS ONE 2014;9 (6):e99890 [PubMed]

2013

  • Weterings A. A. W., van Rijsingen I. A. W., Plomp A. S., Zwinderman A. H., Lekanne Deprez R. H., Mannens M. M., van den Bergh Weerman M. A., van der Wal A. C., Pinto-Sietsma S. J. A novel lamin A/C mutation in a Dutch family with premature atherosclerosis Atherosclerosis 2013;229 (1):169-173 [PubMed]
  • Mulders Ties A., Pinto-Sietsma Sara-Joan Considering a possible application to prevent or to treat arterial stiffness : Reply Heart (British Cardiac Society) 2013;99 (1):66-67 [PubMed]
  • van Rijsingen Ingrid A. W., Bakker Annemieke, Azim Donija, Hermans-van Ast Johanna F., van der Kooi Anneke J., van Tintelen J. Peter, van den Berg Maarten P., Christiaans Imke, Lekanne dit Deprez Ronald H., Wilde Arthur A. M., Zwinderman Aeilko H., Meijers Joost C. M., Grootemaat Anita E., Nieuwland Rienk, Pinto Yigal M., Pinto-Sietsma Sara-Joan Lamin A/C mutation is independently associated with an increased risk of arterial and venous thromboembolic complications International journal of cardiology 2013;168 (1):472-477 [PubMed]
  • Mulders Ties A., Nieuwdorp Max, Stroes Erik S., Vink Hans, Pinto-Sietsma Sara-Joan Non-invasive assessment of microvascular dysfunction in families with premature coronary artery disease International journal of cardiology 2013;168 (5):5026-5028 [PubMed]
  • Mulders Ties A. Premature atherosclerosis: sounds familial 2013. 209p. ISBN 9789461936662. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Stroes E. S. G.; Co-supervisors: Pinto-Sietsma S. J., Vink H.)

2012

  • Visser M. E., Dallinga-Thie G. M., Pinto-Sietsma S. J., Defesche J. C., Stroes E. S., van der Valk P. R. APOE1 mutation in a patient with type III hyperlipoproteinaemia: detailed genetic analysis required Netherlands journal of medicine 2012;70 (6):278-280 [PubMed]
  • Mulders Ties A., Maurissen Lisbeth Fa, Meyer Zainna, Hameeteman Marijn, van der Donk Christel, Kroon Abraham A., Ferreira Isabel, Stehouwer Coen DA, Hackeng Tilman M., Pinto-Sietsma Sara-Joan A positive family history for premature cardiovascular disease identifies patients prone to recurrent arterial thrombotic events European journal of preventive cardiology 2012;19 (6):1465-1473 [PubMed]
  • Mulders Ties A., van den Bogaard Bas, Bakker Annemieke, Trip Mieke D., Stroes Erik S., van den Born Bert-Jan H., Pinto-Sietsma Sara-Joan Arterial stiffness is increased in families with premature coronary artery disease Heart (British Cardiac Society) 2012;98 (6):490-494 [PubMed]
  • Mulders Ties A., Sivapalaratnam Suthesh, Stroes Erik S. G., Kastelein John J. P., Guerci Alan D., Pinto-Sietsma Sara-Joan Asymptomatic Individuals With a Positive Family History for Premature Coronary Artery Disease and Elevated Coronary Calcium Scores Benefit From Statin Treatment A Post Hoc Analysis From the St. Francis Heart Study JACC. Cardiovascular imaging 2012;5 (3):252-260 [PubMed]
  • Mulders Ties A., Pinto-Sietsma Sara-Joan It is usually the cigarettes that do it reply Heart (British Cardiac Society) 2012;98 (11):891 [PubMed]
  • Sivapalaratnam Suthesh, Basart Hanneke, Watkins Nicholas A., Maiwald Stepanie, Rendon Augusto, Krishnan Unni, Sondermeijer Brigitte M., Creemers Esther E., Pinto-Sietsma Sara J., Hovingh Kees, Ouwehand Willem H., Kastelein John J. P., Goodall Alison H., Trip Mieke D. Monocyte Gene Expression Signature of Patients with Early Onset Coronary Artery Disease PLoS ONE 2012;7 (2):e32166 [PubMed]

2011

  • Steckelings U. Muscha, de Mey Jo G. R., Pinto-Sietsma Sara-Joan, Henrion Daniel, Unger Thomas Advances in cardiovascular research. 15th Annual Meeting of the European Council for Cardiovascular Research (ECCR). La Colle sur Loup, France, 8–10 October 2010 Expert review of cardiovascular therapy 2011;9 (1):21-25 [PubMed]
  • Mulders Ties A., Meyer Zainna, van der Donk Christel, Kroon Abraham A., Ferreira Isabel, Stehouwer Coen D. A., Pinto-Sietsma Sara-Joan Patients with premature cardiovascular disease and a positive family history for cardiovascular disease are prone to recurrent events International journal of cardiology 2011;153 (1):64-67 [PubMed]
  • Sondermeijer Brigitte M., Bakker Annemieke, Halliani Amalia, de Ronde Maurice W. J., Marquart Arnoud A., Tijsen Anke J., Mulders Ties A., Kok Maayke G. M., Battjes Suzanne, Maiwald Steffi, Sivapalaratnam Suthesh, Trip Mieke D., Moerland Perry D., Meijers Joost C. M., Creemers Esther E., Pinto-Sietsma Sara-Joan Platelets in patients with premature coronary artery disease exhibit upregulation of miRNA340* and miRNA624* PLoS ONE 2011;6 (10):e25946 [PubMed]
  • Geerse Daniël A., Span Lambert F. R., Pinto-Sietsma Sara-Joan, van Mook Walther N. K. A. Prognosis of patients with haematological malignancies admitted to the intensive care unit: Sequential Organ Failure Assessment (SOFA) trend is a powerful predictor of mortality European journal of internal medicine 2011;22 (1):57-61 [PubMed]

2005

  • Gielen Marij, Pinto-Sietsma Sara-Joan, Zeegers Maurice P., Loos Ruth J., Fagard Robert, de Leeuw Peter W., Beunen Gaston, Derom Catherine, Vlietinck Robert Birth weight and creatinine clearance in young adult twins: influence of genetic, prenatal, and maternal factors Journal of the American Society of Nephrology 2005;16 (8):2471-2476 [PubMed]

2003

  • Pinto-Sietsma Sara-Joan, Navis Gerjan, Janssen Wilbert M. T., de Zeeuw Dick, Gans Reinhold O. B., de Jong Paul E. A central body fat distribution is related to renal function impairment, even in lean subjects American journal of kidney diseases 2003;41 (4):733-741 [PubMed]
  • Pinto-Sietsma Sara-Joan, Herrmann Stefan-Martin, Schmidt-Petersen Klaus, Niu Tianhua, Hillege Hans L., Janssen Wilbert M. T., de Zeeuw Dick, de Jong Paul, Kreutz Reinhold Role of the endothelin-1 gene locus for renal impairment in the general nondiabetic population Journal of the American Society of Nephrology 2003;14 (10):2596-2602 [PubMed]
  • de Jong Paul E., Hillege Hans L., Pinto-Sietsma Sara Joan, de Zeeuw Dick Screening for microalbuminuria in the general population: a tool to detect subjects at risk for progressive renal failure in an early phase? Nephrology, dialysis, transplantation 2003;18 (1):10-13 [PubMed]

2002

  • Gschwend Simone, Pinto-Sietsma Sara-Joan, Buikema Hendrik, Pinto Yigal M., van Gilst Wiek H., Schulz Angela, de Zeeuw Dick, Kreutz Reinhold Impaired coronary endothelial function in a rat model of spontaneous albuminuria Kidney international 2002;62 (1):181-191 [PubMed]
  • de Jong P. E., Verhave J. C., Pinto-Sietsma S. J., Hillege H. L. Obesity and target organ damage: the kidney International journal of obesity (2005) 2002;26 (Suppl. 4):S21-S24 [PubMed]

2000

  • Janssen W. M., Hillege H., Pinto-Sietsma S. J., Bak A. A., de Zeeuw D., de Jong P. E. Low levels of urinary albumin excretion are associated with cardiovascular risk factors in the general population Clinical chemistry and laboratory medicine 2000;38 (11):1107-1110 [PubMed]
  • Pinto Y. M., Pinto-Sietsma S. J., Philipp T., Engler S., Kossamehl P., Hocher B., Marquardt H., Sethmann S., Lauster R., Merker H. J., Paul M. Reduction in left ventricular messenger RNA for transforming growth factor beta(1) attenuates left ventricular fibrosis and improves survival without lowering blood pressure in the hypertensive TGR(mRen2)27 Rat Hypertension 2000;36 (5):747-754 [PubMed]
  • Pinto-Sietsma S. J., Mulder J., Janssen W. M., Hillege H. L., de Zeeuw D., de Jong P. E. Smoking is related to albuminuria and abnormal renal function in nondiabetic persons Annals of internal medicine 2000;133 (8):585-591 [PubMed]
  • Pinto-Sietsma S. J., Janssen W. M., Hillege H. L., Navis G., de Zeeuw D., de Jong P. E. Urinary albumin excretion is associated with renal functional abnormalities in a nondiabetic population Journal of the American Society of Nephrology 2000;11 (10):1882-1888 [PubMed]

1999

  • Pinto-Sietsma S. J., Hillege H. L., Janssen W. M. Inadequate management of blood pressure in a hypertensive population New England journal of medicine 1999;340 (20):1593-1595 [PubMed]

1998

  • Pinto-Sietsma S. J., Paul M. A role for endothelin in the pathogenesis of hypertension: fact or fiction? Kidney international 1998;54 (Suppl. 67):S115-S121 [PubMed]
  • van Waardenburg R. C., Meijer C., Pinto-Sietsma S. J., de Vries E. G., Timens W., Mulder N. M. Effects of c-myc oncogene modulation on differentiation of human small cell lung carcinoma cell lines Anticancer research 1998;18 (1A):91-95 [PubMed]
  • Pinto Y. M., Pinto S. J., Paul M., Merker H. J. The electron microscopic morphology of the common carotid artery in rats Annals of anatomy = Anatomischer Anzeiger 1998;180 (3):223-235 [PubMed]

1997

  • Pinto-Sietsma S. J., Paul M. Transgenic rats as models for hypertension Journal of human hypertension 1997;11 (9):577-581 [PubMed]
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